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Caroline Savage

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Sahithi J Kuravi; G Ed Rainger; Simon C Satchell; Caroline O S Savage; Anne Bevins; Lorraine Harper; Julie M Williams; Samantha Tull
Neutrophil serine proteases mediate inflammatory cell recruitment by glomerular endothelium and progression towards dysfunction.
Stuart W Smith; Sourabh Chand; Caroline O S Savage
Biology of the renal pericyte.
Lorraine Harper; Peter Hoglund; David Jayne; Raashid Luqmani; Matthew David Morgan; Charles Pusey; Niels Rasmussen; Caroline O S Savage; Vladimir Tesar; Phillipe Vanhille; Michael Walsh; Richard Watts; Kerstin Westman; Daniel Blockmans; Annette Bruchfeld; Kirsten de Groot; Luis Felipe Flores-Suarez; Oliver Flossmann
Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis: long-term follow-up.

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2012: Sahithi J Kuravi; G Ed Rainger; Simon C Satchell; Caroline O S Savage; Anne Bevins; Lorraine Harper; Julie M Williams; Samantha Tull
Neutrophil serine proteases mediate inflammatory cell recruitment by glomerular endothelium and progression towards dysfunction.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012;27(12):4331-8.
2012: Stuart W Smith; Sourabh Chand; Caroline O S Savage
Biology of the renal pericyte.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012;27(6):2149-55.
2012: Lorraine Harper; Peter Hoglund; David Jayne; Raashid Luqmani; Matthew David Morgan; Charles Pusey; Niels Rasmussen; Caroline O S Savage; Vladimir Tesar; Phillipe Vanhille; Michael Walsh; Richard Watts; Kerstin Westman; Daniel Blockmans; Annette Bruchfeld; Kirsten de Groot; Luis Felipe Flores-Suarez; Oliver Flossmann
Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis: long-term follow-up.
Annals of the rheumatic diseases 2012;71(6):955-60.
2012: Mary-Jane C J Guerry; Lorraine Harper; Paul Brogan; Ian N Bruce; David P D'Cruz; Raashid Luqmani; Charles D Pusey; Alan D Salama; Caroline O S Savage; David G I Scott; Richard Watts; David R W Jayne
Recommendations for the use of rituximab in anti-neutrophil cytoplasm antibody-associated vasculitis.
Rheumatology (Oxford, England) 2012;51(4):634-43.
2012: Shaun M Flint; Caroline O S Savage
Anti-LAMP-2 autoantibodies in ANCA-associated pauci-immune glomerulonephritis.
Journal of the American Society of Nephrology : JASN 2012;23(3):378-80.
2012: Samantha Tull; Julie M Williams; Stephen Young; Bahjat Al-Ani; Anne Bevins; Lorraine Harper; Sahithi Jyothsna Kuravi; G Ed Rainger; Simon C Satchell; Caroline O S Savage
PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells.
PloS one 2012;7(8):e43916.
2011: N J Holden; Matthew David Morgan; R J Pepper; Alan D Salama; A Challa; J Gordon; Lorraine Harper; Julie Williams; Caroline O S Savage
ANCA-stimulated neutrophils release BLyS and promote B cell survival: a clinically relevant cellular process.
Annals of the rheumatic diseases 2011;70(12):2229-33.
2011: H Morris; J Perez; C D Pusey; A D Salama; Caroline O S Savage; S W Smith; R Stockley; S Wieczorek; J Williams; A M Wood; K Herrmann; J U Holle; D A Lomas; A P Maxwell; A J McKnight; E Miranda; Matthew David Morgan; U I Ekeowa; L Guillevin; Lorraine Harper
ANCA-associated vasculitis is linked to carriage of the Z allele of α₁ antitrypsin and its polymers.
Annals of the rheumatic diseases 2011;70(10):1851-6.
2011: Stuart W Smith; Christopher D Buckley; Paul Cockwell; Adam P Croft; Kevin S Eardley; Alexander J Howie; Clare M Isacke; Joel Nwosu; Caroline O S Savage
CD248+ stromal cells are associated with progressive chronic kidney disease.
Kidney international 2011;80(2):199-207.
2011: Matthew D Morgan; Paul A Moss; Desley A H Neil; Annette Pachnio; Niels Rasmussen; David Roberts; Caroline O S Savage; Ingeborg Bajema; Jusnara Begum; Lorraine Harper
CD4+CD28- T cell expansion in granulomatosis with polyangiitis (Wegener's) is driven by latent cytomegalovirus infection and is associated with an increased risk of infection and mortality.
Arthritis and rheumatism 2011;63(7):2127-37.
2011: Abdurrezagh Mansur; Peter Nightingale; Weng Chin Oh; Alexander J Howie; Steven Jacques; Mark Little; Caroline O S Savage
Immune profile and Epstein-Barr virus infection in acute interstitial nephritis: an immunohistochemical study in 78 patients.
Nephron. Clinical practice 2011;119(4):c293-300.
2011: Neil J Holden; Caroline O S Savage; Michael J Wakelam; Lorraine Harper; Stephen P Young; Julie M Williams
A dual role for diacylglycerol kinase generated phosphatidic acid in autoantibody-induced neutrophil exocytosis.
Molecular medicine (Cambridge, Mass.) 2011;17(11-12):1242-52.
2011: Matthew D Morgan; Mark T Drayson; Caroline O S Savage; Lorraine Harper
Addition of infliximab to standard therapy for ANCA-associated vasculitis.
Nephron. Clinical practice 2011;117(2):c89-97.
2010: Annelies E Berden; Sarah L Nolan; Hannah L Morris; Rogier M Bertina; Dianhdra D Erasmus; Chris Hagen; Donal P Hayes; Nico H van Tilburg; Jan A Bruijn; Caroline O S Savage; Ingeborg M Bajema; Peter Hewins
Anti-plasminogen antibodies compromise fibrinolysis and associate with renal histology in ANCA-associated vasculitis.
Journal of the American Society of Nephrology : JASN 2010;21(12):2169-79.
2010: Julia Flint; Matthew D Morgan; Caroline O S Savage
Pathogenesis of ANCA-associated vasculitis.
Rheumatic diseases clinics of North America 2010;36(3):463-77.
2010: Clara J Day; Alec J Howie; Peter Nightingale; Shazia Shabir; Dwomoa Adu; Caroline O S Savage; Peter Hewins
Prediction of ESRD in pauci-immune necrotizing glomerulonephritis: quantitative histomorphometric assessment and serum creatinine.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2010;55(2):250-8.
2009: Lavanya Kamesh; Joanne M Heward; Julie M Williams; Stephen C L Gough; Konstantia-Maria Chavele; Alan Salama; Charles Pusey; Caroline O S Savage; Lorraine Harper
CT60 and +49 polymorphisms of CTLA 4 are associated with ANCA-positive small vessel vasculitis.
Rheumatology (Oxford, England) 2009;48(12):1502-5.
2009: Matthew David Morgan; Jennifer Turnbull; Umut Selamet; Manvir Kaur-Hayer; Peter Nightingale; Charles J Ferro; Caroline O S Savage; Lorraine Harper
Increased incidence of cardiovascular events in patients with antineutrophil cytoplasmic antibody-associated vasculitides: a matched-pair cohort study.
Arthritis and rheumatism 2009;60(11):3493-500.
2009: Abdullah Hussain; Tanya Pankhurst; Margaret Goodall; Rachel Colman; Roy Jefferis; Caroline O S Savage; Julie M Williams
Chimeric IgG4 PR3-ANCA induces selective inflammatory responses from neutrophils through engagement of Fcgamma receptors.
Immunology 2009;128(2):236-44.
2009: Rachel B Jones; Alastair J Ferraro; Afzal N Chaudhry; Paul Brogan; Alan D Salama; Kenneth G C Smith; Caroline O S Savage; David Jayne
A multicenter survey of rituximab therapy for refractory antineutrophil cytoplasmic antibody-associated vasculitis.
Arthritis and rheumatism 2009;60(7):2156-68.
2009: Caroline O S Savage
Vascular biology and vasculitis.
APMIS. Supplementum 2009;(127):37-40.
2009: Annelies E Berden; Cees G M Kallenberg; Caroline O S Savage; Benito A Yard; Wayel H Abdulahad; Emile de Heer; Jan A Bruijn; Ingeborg M Bajema
Cellular immunity in Wegener's granulomatosis: characterizing T lymphocytes.
Arthritis and rheumatism 2009;60(6):1578-87.
2009: Kirsten de Groot; Lorraine Harper; David Jayne; Luis Felipe Flores Suarez; Gina Gregorini; Wolfgang L Gross; Raashid Luqmani; Charles D Pusey; Niels Rasmussen; Renato A Sinico; Vladimir Tesar; Philippe Vanhille; Kerstin Westman; Caroline O S Savage
Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized trial.
Annals of internal medicine 2009;150(10):670-80.
2009: Tanya Pankhurst; Caroline O S Savage; Mark Little
Review article: Leukocyte-endothelial dysregulation in systemic small vessel vasculitis.
Nephrology (Carlton, Vic.) 2009;14(1):3-10.
2009: Clara J Day; Graham W Lipkin; Caroline O S Savage
Lupus nephritis and pregnancy in the 21st century.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009;24(2):344-7.
2008: Alastair J Ferraro; Stuart W Smith; Desley Neil; Caroline O S Savage
Relapsed Wegener's granulomatosis after rituximab therapy--B cells are present in new pathological lesions despite persistent 'depletion' of peripheral blood.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008;23(9):3030-2.
2008: Mark Little; Caroline O S Savage
The role of the endothelium in systemic small vessel vasculitis.
Clinical and experimental rheumatology 2008;26(3 Suppl 49):S135-40.
2008: Sarah L Nolan; Neena Kalia; Gerard B Nash; Dia Kamel; Peter Heeringa; Caroline O S Savage
Mechanisms of ANCA-mediated leukocyte-endothelial cell interactions in vivo.
Journal of the American Society of Nephrology : JASN 2008;19(5):973-84.
2008: Alastair J Ferraro; Mark T Drayson; Caroline O S Savage; Ian C M MacLennan
Levels of autoantibodies, unlike antibodies to all extrinsic antigen groups, fall following B cell depletion with Rituximab.
European journal of immunology 2008;38(1):292-8.
2007: Sidonia Mihai; Mircea T Chiriac; Josep E Herrero-González; Margaret Goodall; Roy Jefferis; Caroline O S Savage; Detlef Zillikens; Cassian Sitaru
IgG4 autoantibodies induce dermal-epidermal separation.
Journal of cellular and molecular medicine 2007;11(5):1117-28.
2007: Caroline O S Savage; Julie Williams
Anti endothelial cell antibodies in vasculitis.
Journal of the American Society of Nephrology : JASN 2007;18(9):2424-6.
2007: A Rajp; Dwomoa Adu; Caroline O S Savage
Meta-analysis of myeloperoxidase G-463/A polymorphism in anti-neutrophil cytoplasmic autoantibody-positive vasculitis.
Clinical and experimental immunology 2007;149(2):251-6.
2007: Frauke Weidanz; Clara J Day; Peter Hewins; Caroline O S Savage; Lorraine Harper
Recurrences and infections during continuous immunosuppressive therapy after beginning dialysis in ANCA-associated vasculitis.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2007;50(1):36-46.
2007: David Jayne; Gill Gaskin; Niels Rasmussen; Daniel Abramowicz; Franco Ferrario; Loic Guillevin; Eduardo Mirapeix; Caroline O S Savage; renato alberto sinico; Coen A Stegeman; Kerstin Westman; Fokko J van der Woude; Robert A F de Lind van Wijngaarden; Charles D Pusey
Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis.
Journal of the American Society of Nephrology : JASN 2007;18(7):2180-8.
2007: Lavanya Kamesh; Joanne M Heward; Julie Williams; S C L Gough; Caroline O S Savage; Lorraine Harper
Mannose-binding lectin gene polymorphisms in a cohort study of ANCA-associated small vessel vasculitis.
Rheumatology (Oxford, England) 2007;46(7):1076-8.
2007: Umut Selamet; Yuriy B Kovaliv; Caroline O S Savage; Lorraine Harper
ANCA-associated vasculitis: new options beyond steroids and cytotoxic drugs.
Expert opinion on investigational drugs 2007;16(5):689-703.
2007: Rachel Colman; Abdullah Hussain; Margaret Goodall; Stephen Young; Tanya Pankhurst; Xiaomei Lu; Roy Jefferis; Caroline O S Savage; Julie Williams
Chimeric antibodies to proteinase 3 of IgG1 and IgG3 subclasses induce different magnitudes of functional responses in neutrophils.
Annals of the rheumatic diseases 2007;66(5):676-82.
2007: Julie Williams; Trevor R Pettitt; Wendy Powell; Joe Grove; Caroline O S Savage; Michael J O Wakelam
Antineutrophil cytoplasm antibody-stimulated neutrophil adhesion depends on diacylglycerol kinase-catalyzed phosphatidic acid formation.
Journal of the American Society of Nephrology : JASN 2007;18(4):1112-20.
2007: Caroline O S Savage
Endothelium and regulatory cell interactions.
Clinical and experimental rheumatology 2007;25(1 Suppl 44):S46-8.
2006: Christopher A Skilbeck; Xiaomei Lu; Sajila Sheikh; Caroline O S Savage; Gerard B Nash
Capture of flowing human neutrophils by immobilised immunoglobulin: roles of Fc-receptors CD16 and CD32.
Cellular immunology 2006;241(1):26-31.
2006: X Lu; A Garfield; G Ed Rainger; Caroline O S Savage; Gerard B Nash
Mediation of endothelial cell damage by serine proteases, but not superoxide, released from antineutrophil cytoplasmic antibody-stimulated neutrophils.
Arthritis and rheumatism 2006;54(5):1619-28.
2006: Kevin S Eardley; Daniel Zehnder; Marcus Quinkler; Julia Lepenies; R L Bates; Caroline O S Savage; Alexander J Howie; Dwomoa Adu; Paul Cockwell
The relationship between albuminuria, MCP-1/CCL2, and interstitial macrophages in chronic kidney disease.
Kidney international 2006;69(7):1189-97.
2006: Tanya Pankhurst; Caroline O S Savage
Pathogenic role of anti-neutrophil cytoplasmic antibodies in vasculitis.
Current opinion in pharmacology 2006;6(2):190-6.
2006: Mark Holland; H Yagi; N Takahashi; K Kato; Caroline O S Savage; D M Goodall; Roy Jefferis
Differential glycosylation of polyclonal IgG, IgG-Fc and IgG-Fab isolated from the sera of patients with ANCA-associated systemic vasculitis.
Biochimica et biophysica acta 2006;1760(4):669-77.
2006: Peter Hewins; Matthew David Morgan; N Holden; Desley A H Neil; Julie Williams; Caroline O S Savage; Lorraine Harper
IL-18 is upregulated in the kidney and primes neutrophil responsiveness in ANCA-associated vasculitis.
Kidney international 2006;69(3):605-15.
2005: Julie U Holle; Julie Williams; Lorraine Harper; Caroline O S Savage; C Mark Taylor
Effect of verocytotoxins (Shiga-like toxins) on human neutrophils in vitro.
Pediatric nephrology (Berlin, Germany) 2005;20(9):1237-44.
2005: Julie Williams; R Colman; C J Brookes; Caroline O S Savage; Lorraine Harper
Anti-endothelial cell antibodies from lupus patients bind to apoptotic endothelial cells promoting macrophage phagocytosis but do not induce apoptosis.
Rheumatology (Oxford, England) 2005;44(7):879-84.
2005: C Newall; S Schinke; Caroline O S Savage; S Hill; Lorraine Harper
Impairment of lung function, health status and functional capacity in patients with ANCA-associated vasculitis.
Rheumatology (Oxford, England) 2005;44(5):623-8.
2005: Matthew David Morgan; Lorraine Harper; X Lu; G Nash; Julie Williams; Caroline O S Savage
Can neutrophils be manipulated in vivo?
Rheumatology (Oxford, England) 2005;44(5):597-601.
2005: Matthew D Morgan; Caroline O S Savage
Vasculitis in the gastrointestinal tract.
Best practice & research. Clinical gastroenterology 2005;19(2):215-33.
2005: Lorraine Harper; Caroline O S Savage
ANCA-associated renal vasculitis at the end of the twentieth century--a disease of older patients.
Rheumatology (Oxford, England) 2005;44(4):495-501.
2005: Alistair J Ferraro; Clara J Day; Mark T Drayson; Caroline O S Savage
Effective therapeutic use of rituximab in refractory Wegener's granulomatosis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2005;20(3):622-5.
2005: Julie Williams; Lavanya Kamesh; Caroline O S Savage
Translating basic science into patient therapy for ANCA-associated small vessel vasculitis.
Clinical science (London, England : 1979) 2005;108(2):101-12.
2005: Wai Y Tse; Gerard B Nash; Peter Hewins; Caroline O S Savage; Dwomoa Adu
ANCA-induced neutrophil F-actin polymerization: implications for microvascular inflammation.
Kidney international 2005;67(1):130-9.
2005: Julie Williams; Caroline O S Savage
Characterization of the regulation and functional consequences of p21ras activation in neutrophils by antineutrophil cytoplasm antibodies.
Journal of the American Society of Nephrology : JASN 2005;16(1):90-6.
2005: Judith W Calderwood; Julie Williams; Matthew David Morgan; Gerard B Nash; Caroline O S Savage
ANCA induces beta2 integrin and CXC chemokine-dependent neutrophil-endothelial cell interactions that mimic those of highly cytokine-activated endothelium.
Journal of leukocyte biology 2005;77(1):33-43.
2004: Tanya Pankhurst; Caroline O S Savage; Caroline Gordon; Lorraine Harper
Malignancy is increased in ANCA-associated vasculitis.
Rheumatology (Oxford, England) 2004;43(12):1532-5.
2004: Mark Holland; Peter Hewins; Margaret Goodall; Dwomoa Adu; Roy Jefferis; Caroline O S Savage
Anti-neutrophil cytoplasm antibody IgG subclasses in Wegener's granulomatosis: a possible pathogenic role for the IgG4 subclass.
Clinical and experimental immunology 2004;138(1):183-92.
2004: Lorraine Harper; L Chin; Jacqueline Daykin; Amit Allahabadia; Joanne M Heward; S C L Gough; Caroline O S Savage; Jayne A Franklyn
Propylthiouracil and carbimazole associated-antineutrophil cytoplasmic antibodies (ANCA) in patients with Graves' disease.
Clinical endocrinology 2004;60(6):671-5.
2004: Lorraine Harper; Julie Williams; Caroline O S Savage
The importance of resolution of inflammation in the pathogenesis of ANCA-associated vasculitis.
Biochemical Society transactions 2004;32(Pt3):502-6.
2004: Peter Hewins; Julie Williams; Michael J O Wakelam; Caroline O S Savage
Activation of Syk in neutrophils by antineutrophil cytoplasm antibodies occurs via Fcgamma receptors and CD18.
Journal of the American Society of Nephrology : JASN 2004;15(3):796-808.
2003: Clara J Day; Peter Hewins; Caroline O S Savage
New developments in the pathogenesis of ANCA-associated vasculitis.
Clinical and experimental rheumatology 2003;21(6 Suppl 32):S35-48.
2003: Abigail R Clayton; Rebecca L Prue; Lorraine Harper; Mark T Drayson; Caroline O S Savage
Dendritic cell uptake of human apoptotic and necrotic neutrophils inhibits CD40, CD80, and CD86 expression and reduces allogeneic T cell responses: relevance to systemic vasculitis.
Arthritis and rheumatism 2003;48(8):2362-74.
2003: Abdurrezagh Elmedhem; Dwomoa Adu; Caroline O S Savage
Relapse rate and outcome of ANCA-associated small vessel vasculitis after transplantation.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2003;18(5):1001-4.
2003: Abigail R Clayton; Caroline O S Savage
Production of antineutrophil cytoplasm antibodies derived from circulating B cells in patients with systemic vasculitis.
Clinical and experimental immunology 2003;132(1):174-9.
2003: Julie Williams; Anne Ben-Smith; Peter Hewins; Stephen K Dove; Philip Hughes; Robert McEwan; Michael J O Wakelam; Caroline O S Savage
Activation of the G(i) heterotrimeric G protein by ANCA IgG F(ab')2 fragments is necessary but not sufficient to stimulate the recruitment of those downstream mediators used by intact ANCA IgG.
Journal of the American Society of Nephrology : JASN 2003;14(3):661-9.
2003: Peter Hewins; Caroline O S Savage
ANCA and neutrophil biology.
Kidney & blood pressure research 2003;26(4):221-5.
2002: Clara J Day; Paul Cockwell; Graham W Lipkin; Caroline O S Savage; Alexander J Howie; Dwomoa Adu
Mycophenolate mofetil in the treatment of resistant idiopathic nephrotic syndrome.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2002;17(11):2011-3.
2002: Caroline O S Savage
The evolving pathogenesis of systemic vasculitis.
Clinical medicine (London, England) 2002;2(5):458-64.
2002: Mark Holland; K Takada; T Okumoto; N Takahashi; K Kato; Dwomoa Adu; Anne Ben-Smith; Lorraine Harper; Caroline O S Savage; Roy Jefferis
Hypogalactosylation of serum IgG in patients with ANCA-associated systemic vasculitis.
Clinical and experimental immunology 2002;129(1):183-90.
2002: Srabasti J Chakravorty; Paul Cockwell; John Girdlestone; Christopher J Brooks; Caroline O S Savage
Fractalkine expression on human renal tubular epithelial cells: potential role in mononuclear cell adhesion.
Clinical and experimental immunology 2002;129(1):150-9.
2002: Lavanya Kamesh; Lorraine Harper; Caroline O S Savage
ANCA-positive vasculitis.
Journal of the American Society of Nephrology : JASN 2002;13(7):1953-60.
2002: Paul Cockwell; Judith W Calderwood; Christopher J Brooks; Srabasti J Chakravorty; Caroline O S Savage
Chemoattraction of T cells expressing CCR5, CXCR3 and CX3CR1 by proximal tubular epithelial cell chemokines.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2002;17(5):734-44.
2002: J C Cooper; Sharon Hughes; Anne Ben-Smith; Caroline O S Savage; John Winer
T cell recognition of a non-protein antigen preparation of Campylobacter jejuni in patients with Guillain-Barré syndrome.
Journal of neurology, neurosurgery, and psychiatry 2002;72(3):413-4.
2002: Stephen R C Benson; Andrew R Ready; Caroline O S Savage
Donor platelet and leukocyte load identify renal allografts at an increased risk of acute rejection.
Transplantation 2002;73(1):93-100.
2002: Caroline O S Savage; Lorraine Harper; Mark Holland
New findings in pathogenesis of antineutrophil cytoplasm antibody-associated vasculitis.
Current opinion in rheumatology 2002;14(1):15-22.
2002: Paul Cockwell; Srabasti J Chakravorty; John Girdlestone; Caroline O S Savage
Fractalkine expression in human renal inflammation.
The Journal of pathology 2002;196(1):85-90.
2001: DJ Radford; N Thin Luu; Peter Hewins; Gerard B Nash; Caroline O S Savage
Antineutrophil cytoplasmic antibodies stabilize adhesion and promote migration of flowing neutrophils on endothelial cells.
Arthritis and rheumatism 2001;44(12):2851-61.
2001: Lorraine Harper; Caroline O S Savage
Leukocyte-endothelial interactions in antineutrophil cytoplasmic antibody-associated systemic vasculitis.
Rheumatic diseases clinics of North America 2001;27(4):887-903.
2001: Caroline O S Savage
ANCA-associated renal vasculitis.
Kidney international 2001;60(4):1614-27.
2001: Anne Ben-Smith; Stephen K Dove; A Martin; Michael J O Wakelam; Caroline O S Savage
Antineutrophil cytoplasm autoantibodies from patients with systemic vasculitis activate neutrophils through distinct signaling cascades: comparison with conventional Fcgamma receptor ligation.
Blood 2001;98(5):1448-55.
2001: C E Balding; Alexander J Howie; Adrian B Drake-Lee; Caroline O S Savage
Th2 dominance in nasal mucosa in patients with Wegener's granulomatosis.
Clinical and experimental immunology 2001;125(2):332-9.
2001: Srabasti J Chakravorty; Alexander J Howie; John Girdlestone; Dean Gentle; Caroline O S Savage
Potential role for monocyte chemotactic protein-4 (MCP-4) in monocyte/macrophage recruitment in acute renal inflammation.
The Journal of pathology 2001;194(2):239-46.
2001: Lorraine Harper; Paul Cockwell; Dwomoa Adu; Caroline O S Savage
Neutrophil priming and apoptosis in anti-neutrophil cytoplasmic autoantibody-associated vasculitis.
Kidney international 2001;59(5):1729-38.
2001: Lorraine Harper; DJ Radford; T Plant; Mark T Drayson; Dwomoa Adu; Caroline O S Savage
IgG from myeloperoxidase-antineutrophil cytoplasmic antibody-positive patients stimulates greater activation of primed neutrophils than IgG from proteinase 3-antineutrophil cytosplasmic antibody-positive patients.
Arthritis and rheumatism 2001;44(4):921-30.
2001: Wai Y Tse; J Williams; A Pall; M Wilkes; Caroline O S Savage; Dwomoa Adu
Antineutrophil cytoplasm antibody-induced neutrophil nitric oxide production is nitric oxide synthase independent.
Kidney international 2001;59(2):593-600.
2000: J C Cooper; Anne Ben-Smith; Caroline O S Savage; John Winer
Unusual T cell receptor phenotype V gene usage of gamma delta T cells in a line derived from the peripheral nerve of a patient with Guillain-Barré syndrome.
Journal of neurology, neurosurgery, and psychiatry 2000;69(4):522-4.
2000: Lorraine Harper; Maria Alice S Ferreira; Alexander J Howie; Caroline O S Savage; Nick Richards; Jonathan Michael; Dwomoa Adu
Treatment of vasculitic IgA nephropathy.
Journal of nephrology 2000;13(5):360-6.
2000: Lorraine Harper; Y Ren; J Savill; Dwomoa Adu; Caroline O S Savage
Antineutrophil cytoplasmic antibodies induce reactive oxygen-dependent dysregulation of primed neutrophil apoptosis and clearance by macrophages.
The American journal of pathology 2000;157(1):211-20.
2000: DJ Radford; Caroline O S Savage; Gerard B Nash
Treatment of rolling neutrophils with antineutrophil cytoplasmic antibodies causes conversion to firm integrin-mediated adhesion.
Arthritis and rheumatism 2000;43(6):1337-45.
2000: Caroline O S Savage; Lorraine Harper; Paul Cockwell; Dwomoa Adu; Alexander J Howie
ABC of arterial and vascular disease: vasculitis.
BMJ (Clinical research ed.) 2000;320(7245):1325-8.
2000: Wai Y Tse; S Abadeh; Roy Jefferis; Caroline O S Savage; Dwomoa Adu
Neutrophil FcgammaRIIIb allelic polymorphism in anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitis.
Clinical and experimental immunology 2000;119(3):574-7.
2000: Lorraine Harper; Caroline O S Savage
Pathogenesis of ANCA-associated systemic vasculitis.
The Journal of pathology 2000;190(3):349-59.
2000: Abigail R Clayton; Caroline O S Savage
What you should know about PR3-ANCA. Evidence for the role of T cells in the pathogenesis of systemic vasculitis.
Arthritis research 2000;2(4):260-2.
2000: Peter Hewins; J W Tervaert; Caroline O S Savage; C G Kallenberg
Is Wegener's granulomatosis an autoimmune disease?
Current opinion in rheumatology 2000;12(1):3-10.
1999: DJ Radford; J Michael Lord; Caroline O S Savage
The activation of the neutrophil respiratory burst by anti-neutrophil cytoplasm autoantibody (ANCA) from patients with systemic vasculitis requires tyrosine kinases and protein kinase C activation.
Clinical and experimental immunology 1999;118(1):171-9.
1999: Wai Y Tse; S Abadeh; A McTiernan; Roy Jefferis; Caroline O S Savage; Dwomoa Adu
No association between neutrophil FcgammaRIIa allelic polymorphism and anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitis.
Clinical and experimental immunology 1999;117(1):198-205.
1999: Lorraine Harper; Caroline O S Savage
Treatment of IgA nephropathy.
Lancet 1999;353(9156):860-2.
1999: Paul Cockwell; Christopher J Brooks; Dwomoa Adu; Caroline O S Savage
Interleukin-8: A pathogenetic role in antineutrophil cytoplasmic autoantibody-associated glomerulonephritis.
Kidney international 1999;55(3):852-63.
1999: Srabasti J Chakravorty; Alexander J Howie; Paul Cockwell; Dwomoa Adu; Caroline O S Savage
T lymphocyte adhesion mechanisms within inflamed human kidney: studies with a Stamper-Woodruff assay.
The American journal of pathology 1999;154(2):503-14.
1999: Lorraine Harper; Caroline O S Savage
Mechanisms of endothelial injury in systemic vasculitis.
Advances in nephrology from the Necker Hospital 1999;29():1-15.
1998: Paul Cockwell; Alexander J Howie; Dwomoa Adu; Caroline O S Savage
In situ analysis of C-C chemokine mRNA in human glomerulonephritis.
Kidney international 1998;54(3):827-36.
1998: W J King; Christopher J Brooks; R Holder; P Hughes; Dwomoa Adu; Caroline O S Savage
T lymphocyte responses to anti-neutrophil cytoplasmic autoantibody (ANCA) antigens are present in patients with ANCA-associated systemic vasculitis and persist during disease remission.
Clinical and experimental immunology 1998;112(3):539-46.
1998: Lorraine Harper; Paul Cockwell; Caroline O S Savage
Case of propylthiouracil-induced ANCA associated small vessel vasculitis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1998;13(2):455-8.
1998: Caroline O S Savage
Injury mechanisms in vasculitis.
Kidney & blood pressure research 1998;21(2-4):269-70.
1998: Wai Y Tse; Paul Cockwell; Caroline O S Savage
Assessment of disease activity in systemic vasculitis.
Postgraduate medical journal 1998;74(867):1-6.
1997: Paul Cockwell; Caroline O S Savage
Chemokines and their receptors in leukocyte trafficking and renal inflammation.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1997;12(7):1307-10.
1997: Dwomoa Adu; A Pall; Raashid Luqmani; Nick Richards; Alexander J Howie; P Emery; Jonathan Michael; Caroline O S Savage; P A Bacon
Controlled trial of pulse versus continuous prednisolone and cyclophosphamide in the treatment of systemic vasculitis.
QJM : monthly journal of the Association of Physicians 1997;90(6):401-9.
1997: AR Exley; David M Carruthers; Raashid Luqmani; George D Kitas; Caroline Gordon; B A Janssen; Caroline O S Savage; Paul A Bacon
Damage occurs early in systemic vasculitis and is an index of outcome.
QJM : monthly journal of the Association of Physicians 1997;90(6):391-9.
1997: Wai Y Tse; Alexander J Howie; Dwomoa Adu; Caroline O S Savage; Nick Richards; David C Wheeler; Jonathan Michael
Association of vasculitic glomerulonephritis with membranous nephropathy: a report of 10 cases.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1997;12(5):1017-27.
1997: Lorraine Harper; Paul Cockwell; Alexander J Howie; Jonathan Michael; Nick Richards; Caroline O S Savage; David C Wheeler; P A Bacon; Dwomoa Adu
Focal segmental necrotizing glomerulonephritis in rheumatoid arthritis.
QJM : monthly journal of the Association of Physicians 1997;90(2):125-32.
1997: AR Exley; Paul A Bacon; Raashid Luqmani; George D Kitas; Caroline Gordon; Caroline O S Savage; Dwomoa Adu
Development and initial validation of the Vasculitis Damage Index for the standardized clinical assessment of damage in the systemic vasculitides.
Arthritis and rheumatism 1997;40(2):371-80.
1997: Paul Cockwell; Wai Y Tse; Caroline O S Savage
Activation of endothelial cells in thrombosis and vasculitis.
Scandinavian journal of rheumatology 1997;26(3):145-50.
1997: Caroline O S Savage; Christopher J Brooks; Dwomoa Adu; G Richards; Alexander J Howie
Cell adhesion molecule expression within human glomerular and kidney organ culture.
The Journal of pathology 1997;181(1):111-5.
1996: Christopher J Brooks; W J King; D J Radford; Dwomoa Adu; M McGrath; Caroline O S Savage
IL-1 beta production by human polymorphonuclear leucocytes stimulated by anti-neutrophil cytoplasmic autoantibodies: relevance to systemic vasculitis.
Clinical and experimental immunology 1996;106(2):273-9.
1996: Caroline O S Savage
The interaction of endothelial cells with inflammatory cells in vasculitis.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders 1996;13(3):214-6.
1996: C J Lote; Lorraine Harper; Caroline O S Savage
Mechanisms of acute renal failure.
British journal of anaesthesia 1996;77(1):82-9.
1996: Paul Cockwell; D H Adams; Caroline O S Savage
Glycosaminoglycans contribute to multiple functions of vascular endothelial cells.
Clinical and experimental immunology 1996;104(1):1-3.
1996: Paul Cockwell; Caroline O S Savage
Veno-venous haemodiafiltration in meningococcal septicaemia.
Lancet 1996;347(9001):615.
1995: Caroline O S Savage; Christopher J Brooks
Human vascular endothelial cells do not induce anergy in allogeneic CD4+ T cells unless costimulation is prevented.
Transplantation 1995;60(7):734-40.
1995: W J King; Dwomoa Adu; M R Daha; Christopher J Brooks; D J Radford; A A Pall; Caroline O S Savage
Endothelial cells and renal epithelial cells do not express the Wegener's autoantigen, proteinase 3.
Clinical and experimental immunology 1995;102(1):98-105.
1995: Caroline O S Savage; Christopher J Brooks; G C Harcourt; J K Picard; W King; D M Sansom; Nick Willcox
Human vascular endothelial cells process and present autoantigen to human T cell lines.
International immunology 1995;7(3):471-9.
1994: A A Pall; Caroline O S Savage
Mechanisms of endothelial cell injury in vasculitis.
Springer seminars in immunopathology 1994;16(1):23-37.
1993: Christopher J Brooks; A Stackpoole; Caroline O S Savage
Synergistic interactions of CD4+ and CD8+ T cell subsets with human vascular endothelial cells in primary proliferative allogeneic responses.
International immunology 1993;5(9):1041-8.