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Niramol Savaraj

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Min You; Macus T Kuo; Dao M Nguyen; Niramol Savaraj; Javier Varona-Santos; Medhi Wangpaichitr; Chunjing Wu; Lynn Feun
TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation.
Zheng D Liang; Yan Long; Gordon B Mills; Niramol Savaraj; Wen-Bin Tsai; Fan Zhang; Helen H W Chen; Siqing Fu; Mihai Gagea-Iurascu; Bryan T Hennessy; Razelle Kurzrock; M Tien Kuo
Mechanistic basis for overcoming platinum resistance using copper chelating agents.
Macus Tien Kuo; Niramol Savaraj; Siqing Fu; Helen H W Chen
Role of the human high-affinity copper transporter in copper homeostasis regulation and cisplatin sensitivity in cancer chemotherapy.

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2013: Min You; Macus T Kuo; Dao M Nguyen; Niramol Savaraj; Javier Varona-Santos; Medhi Wangpaichitr; Chunjing Wu; Lynn Feun
TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation.
Molecular and cellular biochemistry 2013;374(1-2):181-90.
2012: Zheng D Liang; Yan Long; Gordon B Mills; Niramol Savaraj; Wen-Bin Tsai; Fan Zhang; Helen H W Chen; Siqing Fu; Mihai Gagea-Iurascu; Bryan T Hennessy; Razelle Kurzrock; M Tien Kuo
Mechanistic basis for overcoming platinum resistance using copper chelating agents.
Molecular cancer therapeutics 2012;11(11):2483-94.
2012: Macus Tien Kuo; Niramol Savaraj; Siqing Fu; Helen H W Chen
Role of the human high-affinity copper transporter in copper homeostasis regulation and cisplatin sensitivity in cancer chemotherapy.
Cancer research 2012;72(18):4616-21.
2012: Wen-Bin Tsai; Isamu Aiba; Lynn Feun; Hui-Kuan Lin; Yan Long; Niramol Savaraj; Macus Tien Kuo
Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells.
Cancer research 2012;72(10):2622-33.
2012: Lynn Feun; A A Jungbluth; M Tien Kuo; A Marini; Frederick L Moffat; Steven Rodgers; W Sisson; G Walker; Medhi Wangpaichitr; C J Wu; M You; J Bomalaski; George W Elgart; Niramol Savaraj
Negative argininosuccinate synthetase expression in melanoma tumours may predict clinical benefit from arginine-depleting therapy with pegylated arginine deiminase.
British journal of cancer 2012;106(9):1481-5.
2012: Medhi Wangpaichitr; Chunjing Wu; Min You; Elizabeth J Sullivan; George Theodoropoulos; Lynn Feun; M Tien Kuo; Theodore J Lampidis; Niramol Savaraj
The relationship of thioredoxin-1 and cisplatin resistance: its impact on ROS and oxidative metabolism in lung cancer cells.
Molecular cancer therapeutics 2012;11(3):604-15.
2012: Zheng D Liang; Niramol Savaraj; Wen-Bin Tsai; Mei-Yi Lee; M Tien Kuo
Specificity protein 1 (sp1) oscillation is involved in copper homeostasis maintenance by regulating human high-affinity copper transporter 1 expression.
Molecular pharmacology 2012;81(3):455-64.
2011: Haibin Xi; Metin Kurtoglu; Huaping Liu; Medhi Wangpaichitr; Min You; Xiongfei Liu; Niramol Savaraj; Theodore J Lampidis
2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion.
Cancer chemotherapy and pharmacology 2011;67(4):899-910.
2010: Joshua P Sasine; Niramol Savaraj; Lynn Feun
Topoisomerase I inhibitors in the treatment of primary CNS malignancies: an update on recent trends.
Anti-cancer agents in medicinal chemistry 2010;10(9):683-96.
2010: Macus Tien Kuo; Niramol Savaraj; Lynn Feun
Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes.
Oncotarget 2010;1(4):246-51.
2010: Niramol Savaraj; M You; Chunjing Wu; Medhi Wangpaichitr; M Tien Kuo; Lynn Feun
Arginine deprivation, autophagy, apoptosis (AAA) for the treatment of melanoma.
Current molecular medicine 2010;10(4):405-12.
2010: Min You; Niramol Savaraj; Medhi Wangpaichitr; Chunjing Wu; M Tien Kuo; Javier Varona-Santos; Dao Nguyen; Lynn Feun
The combination of ADI-PEG20 and TRAIL effectively increases cell death in melanoma cell lines.
Biochemical and biophysical research communications 2010;394(3):760-6.
2009: Wen-Bin Tsai; Isamu Aiba; Soo-yong Lee; Lynn Feun; Niramol Savaraj; Macus Tien Kuo
Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1alpha/Sp4.
Molecular cancer therapeutics 2009;8(12):3223-33.
2009: Zheng D Liang; David Stockton; Niramol Savaraj; M Tien Kuo
Mechanistic comparison of human high-affinity copper transporter 1-mediated transport between copper ion and cisplatin.
Molecular pharmacology 2009;76(4):843-53.
2008: Medhi Wangpaichitr; Chunjing Wu; Min You; M T Kuo; Lynn Feun; Theodore J Lampidis; Niramol Savaraj
Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins.
European journal of pharmacology 2008;591(1-3):124-7.
2008: Helen H W Chen; Im-Sook Song; Anwar Hossain; Min-Koo Choi; Y Yamane; Zheng D Liang; Jia Lu; Lily Y-H Wu; Zahid H Siddik; Leo W J Klomp; Niramol Savaraj; M Tien Kuo
Elevated glutathione levels confer cellular sensitization to cisplatin toxicity by up-regulation of copper transporter hCtr1.
Molecular pharmacology 2008;74(3):697-704.
2008: Medhi Wangpaichitr; Niramol Savaraj; Johnathan Maher; Metin Kurtoglu; Theodore J Lampidis
Intrinsically lower AKT, mammalian target of rapamycin, and hypoxia-inducible factor activity correlates with increased sensitivity to 2-deoxy-D-glucose under hypoxia in lung cancer cell lines.
Molecular cancer therapeutics 2008;7(6):1506-13.
2008: Lynn Feun; Niramol Savaraj
Topoisomerase I inhibitors for the treatment of brain tumors.
Expert review of anticancer therapy 2008;8(5):707-16.
2008: Lynn Feun; M You; C J Wu; M T Kuo; Medhi Wangpaichitr; Seth Spector; Niramol Savaraj
Arginine deprivation as a targeted therapy for cancer.
Current pharmaceutical design 2008;14(11):1049-57.
2007: Metin Kurtoglu; Ningguo Gao; Jie Shang; Johnathan Maher; Mark A Lehrman; Medhi Wangpaichitr; Niramol Savaraj; Andrew N Lane; Theodore J Lampidis
Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation.
Molecular cancer therapeutics 2007;6(11):3049-58.
2007: Vy Dinh; Lynn Feun; George W Elgart; Niramol Savaraj
Merkel cell carcinomas.
Hematology/oncology clinics of North America 2007;21(3):527-44; ix.
2007: Lynn Feun; Angela Marini; Howard Landy; Arnold Markoe; Deborah O Heros; Carlos Robles; Cristina Herrera; Niramol Savaraj
Clinical trial of CPT-11 and VM-26/VP-16 for patients with recurrent malignant brain tumors.
Journal of neuro-oncology 2007;82(2):177-81.
2007: M Tien Kuo; Helen H W Chen; Im-Sook Song; Niramol Savaraj; Toshihisa Ishikawa
The roles of copper transporters in cisplatin resistance.
Cancer metastasis reviews 2007;26(1):71-83.
2007: Johnathan Maher; Medhi Wangpaichitr; Niramol Savaraj; Metin Kurtoglu; Theodore J Lampidis
Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose.
Molecular cancer therapeutics 2007;6(2):732-41.
2007: Niramol Savaraj; Seth Spector; Medhi Wangpaichitr; Chunjing Wu; Min You; M Tien Kuo; Carlos Robles; Lynn Feun
The relationship of arginine deprivation, argininosuccinate synthetase and cell death in melanoma.
Drug target insights 2007;2():119-28.
2006: M Tien Kuo; Niramol Savaraj
Roles of reactive oxygen species in hepatocarcinogenesis and drug resistance gene expression in liver cancers.
Molecular carcinogenesis 2006;45(9):701-9.
2006: Lynn Feun; Niramol Savaraj
Pegylated arginine deiminase: a novel anticancer enzyme agent.
Expert opinion on investigational drugs 2006;15(7):815-22.
2006: Yingjie Wei; Yen-Chiu Lin-Lee; Xinlin Yang; Wenping Dai; Sheng Zhao; Feyruz V Rassool; George W Elgart; Lynn Feun; Niramol Savaraj; M Tien Kuo
Molecular cloning of Chinese hamster 1q31 chromosomal fragile site DNA that is important to mdr1 gene amplification reveals a novel gene whose expression is associated with spermatocyte and adipocyte differentiation.
Gene 2006;372():44-52.
2006: M Tien Kuo; Yingjie Wei; Xinlin Yang; Shigeru Tatebe; Jinsong Liu; Patricia Troncoso; Aysegul Sahin; Jae Y Ro; Stanly R Hamilton; Niramol Savaraj
Association of fragile site-associated (FSA) gene expression with epithelial differentiation and tumor development.
Biochemical and biophysical research communications 2006;340(3):887-93.
2005: Paolo A Ascierto; Stefania Scala; Giuseppe Castello; Antonio Daponte; Ester Simeone; Alessandro Ottaiano; Gerardo Beneduce; Vincenzo De Rosa; Francesco Izzo; Maria Teresa Melucci; C Mark Ensor; Archie W Prestayko; Frederick W Holtsberg; John S Bomalaski; Mike A Clark; Niramol Savaraj; Lynn Feun; Theodore F Logan
Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(30):7660-8.
2005: Niramol Savaraj; Yingjie Wei; Hitoshi Unate; Pei-Man Liu; C J Wu; Medhi Wangpaichitr; Diran Xia; Hong-Ji Xu; Shi-Xu Hu; M Tien Kuo
Redox regulation of matrix metalloproteinase gene family in small cell lung cancer cells.
Free radical research 2005;39(4):373-81.
2005: Johnathan Maher; Niramol Savaraj; Waldemar Priebe; Huaping Liu; Theodore J Lampidis
Differential sensitivity to 2-deoxy-D-glucose between two pancreatic cell lines correlates with GLUT-1 expression.
Pancreas 2005;30(2):e34-9.
2005: Niramol Savaraj; Chunjing Wu; Howard Landy; Medhi Wangpaijit; Yingjie Wei; M Tien Kuo; Carlos Robles; Alex Furst; Theodore J Lampidis; Lynn Feun
Procollagen alpha 1 type 1: a potential aide in histopathological grading of glioma.
Cancer investigation 2005;23(7):577-81.
2005: Chunjing Wu; Medhi Wangpaichitr; Lynn Feun; Marcus Tien Kuo; Carlos Robles; Theodore J Lampidis; Niramol Savaraj
Overcoming cisplatin resistance by mTOR inhibitor in lung cancer.
Molecular cancer 2005;4(1):25.
2005: Lynn Feun; Angela Marini; Frederick L Moffat; Niramol Savaraj; Judith Hurley DeLeo; Amitabha Mazumder
Cyclosporine A, alpha-lnterferon and interleukin-2 following chemotherapy with BCNU, DTIC, cisplatin, and tamoxifen: a phase II study in advanced melanoma.
Cancer investigation 2005;23(1):3-8.
2004: Im-Sook Song; Niramol Savaraj; Zahid H Siddik; Peiman Liu; Yingjie Wei; Chun Jing Wu; M Tien Kuo
Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells.
Molecular cancer therapeutics 2004;3(12):1543-9.
2004: Howard Landy; Arnold Markoe; Priscilla Potter; Garrett Lasalle; Angela Marini; Niramol Savaraj; Isildinha M Reis; Deborah O Heros; Medhi Wangpaichitr; Lynn Feun
Pilot study of estramustine added to radiosurgery and radiotherapy for treatment of high grade glioma.
Journal of neuro-oncology 2004;67(1-2):215-20.
2004: Gregory Maschek; Niramol Savaraj; Waldemar Priebe; Paul Braunschweiger; Kara Hamilton; George F Tidmarsh; Linda R De Young; Theodore J Lampidis
2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo.
Cancer research 2004;64(1):31-4.
2003: John R Murren; Manuel Modiano; Caroline Clairmont; Paula Lambert; Niramol Savaraj; Terry Doyle; Mario Sznol
Phase I and pharmacokinetic study of triapine, a potent ribonucleotide reductase inhibitor, administered daily for five days in patients with advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(11):4092-100.
2003: Niramol Savaraj; Chunjing Wu; Medhi Wangpaichitr; M Tien Kuo; Theodore J Lampidis; Carlos Robles; Alex Furst; Lynn Feun
Overexpression of mutated MRP4 in cisplatin resistant small cell lung cancer cell line: collateral sensitivity to azidothymidine.
International journal of oncology 2003;23(1):173-9.
2003: Carlos Robles; Alex Furst; P Sriratana; Shenghan Lai; Lucy Chua; E Donnelly; J Solomon; M Sundaram; Lynn Feun; Niramol Savaraj
Phase II study of vinorelbine with low dose prednisone in the treatment of hormone-refractory metastatic prostate cancer.
Oncology reports 2003;10(4):885-9.
2003: Yan Ping Hu; Bushra Haq; Kermit L Carraway; Niramol Savaraj; Theodore J Lampidis
Multidrug resistance correlates with overexpression of Muc4 but inversely with P-glycoprotein and multidrug resistance related protein in transfected human melanoma cells.
Biochemical pharmacology 2003;65(9):1419-25.
2003: Lynn Feun; Christopher B O'Brien; Enrique Molina; Miguel Rodriguez; Lennox Jeffers; Eugene R Schiff; Angela Marini; Niramol Savaraj; Bach Ardalan
Recombinant leukocyte interferon, doxorubicin, and 5FUDR in patients with hepatocellular carcinoma-A phase II trial.
Journal of cancer research and clinical oncology 2003;129(1):17-20.
2003: Ling He; He-Xi Chang; Ting-Chao Chou; Niramol Savaraj; C C Cheng
Design of antineoplastic agents based on the '2-phenylnaphthalene-type' structural pattern--synthesis and biological activity studies of 11H-indolo[3.2-c]quinoline derivatives.
European journal of medicinal chemistry 2003;38(1):101-7.
2002: Huaping Liu; Niramol Savaraj; Waldemar Priebe; Theodore J Lampidis
Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C).
Biochemical pharmacology 2002;64(12):1745-51.
2002: Lynn Feun; Manuel Modiano; King Lee; John Mao; Angela Marini; Niramol Savaraj; Patricia Plezia; Bijan Almassian; Elizabeth Colacino; Jessica Fischer; Susan MacDonald
Phase I and pharmacokinetic study of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) using a single intravenous dose schedule.
Cancer chemotherapy and pharmacology 2002;50(3):223-9.
2002: Lynn Feun; Niramol Savaraj; Judith Hurley DeLeo; Angela Marini
Phase II trial of Paclitaxel and Dacarbazine with filgrastim administration in advanced malignant melanoma.
Cancer investigation 2002;20(3):357-61.
2002: Shigeru Tatebe; Hitoshi Unate; Frank A Sinicrope; Takashi Sakatani; Kenji Sugamura; Masato Makino; Hisao Ito; Niramol Savaraj; Nobuaki Kaibara; M Tien Kuo
Expression of heavy subunit of gamma-glutamylcysteine synthetase (gamma-GCSh) in human colorectal carcinoma.
International journal of cancer. Journal international du cancer 2002;97(1):21-7.
2001: H Liu; Y P Hu; Niramol Savaraj; Waldemar Priebe; Theodore J Lampidis
Hypersensitization of tumor cells to glycolytic inhibitors.
Biochemistry 2001;40(18):5542-7.
2001: Yen-Chiu Lin-Lee; Shigeru Tatebe; Niramol Savaraj; Toshihisa Ishikawa; M Tien Kuo
Differential sensitivities of the MRP gene family and gamma-glutamylcysteine synthetase to prooxidants in human colorectal carcinoma cell lines with different p53 status.
Biochemical pharmacology 2001;61(5):555-63.
2000: Y Hu; Carlos T Moraes; Niramol Savaraj; Waldemar Priebe; Theodore J Lampidis
Rho(0) tumor cells: a model for studying whether mitochondria are targets for rhodamine 123, doxorubicin, and other drugs.
Biochemical pharmacology 2000;60(12):1897-905.
2000: J Zou; Howard Landy; Lynn Feun; R Xu; Theodore J Lampidis; C J Wu; Alex Furst; Niramol Savaraj
Correlation of a unique 220-kDa protein with vitamin D sensitivity in glioma cells.
Biochemical pharmacology 2000;60(9):1361-5.
2000: Lynn Feun; Niramol Savaraj; Judith Hurley DeLeo; A Marini; Shenghan Lai
A clinical trial of intravenous vinorelbine tartrate plus tamoxifen in the treatment of patients with advanced malignant melanoma.
Cancer 2000;88(3):584-8.
1999: K Yamazaki; Gina Spruill; J Rhoderick; JA Spielman; Niramol Savaraj; Eckhard R Podack
Small cell lung carcinomas express shared and private tumor antigens presented by HLA-A1 or HLA-A2.
Cancer research 1999;59(18):4642-50.
1999: Lynn Feun; K R Reddy; T Scagnelli; Jose Yrizarry; Jorge Guerra; Edward Russell; M Schwartz; Niramol Savaraj; Alan Livingstone; Joe U Levi; Lennox Jeffers; Bach Ardalan; Eugene R Schiff
A phase I study of chemoembolization with cisplatin, thiotepa, and lipiodol for primary and metastatic liver cancer.
American journal of clinical oncology 1999;22(4):375-80.
1999: D Kolonias; T Podona; Niramol Savaraj; L Gate; P Cossum; Theodore J Lampidis
Comparison of annamycin to adriamycin in cardiac and MDR tumor cell systems.
Anticancer research 1999;19(2A):1277-83.
1999: H X Chang; T C Chou; Niramol Savaraj; L F Liu; C Yu; C C Cheng
Design of antineoplastic agents based on the "2-phenylnaphthalene-type" structural pattern. 4. Synthesis and biological activity of 2-chloro-3-(substituted phenoxy)-1, 4-naphthoquinones and related 5,8-dihydroxy-1,4-naphthoquinones.
Journal of medicinal chemistry 1999;42(3):405-8.
1998: Waldemar Priebe; M Krawczyk; M Tien Kuo; Y Yamane; Niramol Savaraj; Toshihisa Ishikawa
Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump.
Biochemical and biophysical research communications 1998;247(3):859-63.
1998: M Tien Kuo; J Bao; M Furuichi; Y Yamane; A Gomi; Niramol Savaraj; T Masuzawa; Toshihisa Ishikawa
Frequent coexpression of MRP/GS-X pump and gamma-glutamylcysteine synthetase mRNA in drug-resistant cells, untreated tumor cells, and normal mouse tissues.
Biochemical pharmacology 1998;55(5):605-15.
1997: K Lertratanangkoon; C J Wu; Niramol Savaraj; M L Thomas
Alterations of DNA methylation by glutathione depletion.
Cancer letters 1997;120(2):149-56.
1997: Niramol Savaraj; C J Wu; R Xu; Theodore J Lampidis; Shenghan Lai; E Donnelly; J Solomon; Lynn Feun
Multidrug-resistant gene expression in small-cell lung cancer.
American journal of clinical oncology 1997;20(4):398-403.
1997: Niramol Savaraj; R Xu; Howard Landy; Shenghan Lai; L Sternau; J Solomon; C Wu; Theodore J Lampidis; Lynn Feun
Comparison of topoisomerase I and II expression in primary brain tumor and lung cancer.
Oncology reports 1997;4(4):857-61.
1997: Theodore J Lampidis; Y F Shi; C L Calderon; D Kolonias; H Tapiero; Niramol Savaraj
Accumulation of simple organic cations correlates with differential cytotoxicity in multidrug-resistant and -sensitive human and rodent cells.
Leukemia 1997;11(7):1156-9.
1997: K Lertratanangkoon; Niramol Savaraj; JM Scimeca; M L Thomas
Glutathione depletion-induced thymidylate insufficiency for DNA repair synthesis.
Biochemical and biophysical research communications 1997;234(2):470-5.
1997: Theodore J Lampidis; D Kolonias; T Podona; Mervyn Israel; A R Safa; Leonard Lothstein; Niramol Savaraj; H Tapiero; Waldemar Priebe
Circumvention of P-GP MDR as a function of anthracycline lipophilicity and charge.
Biochemistry 1997;36(9):2679-85.
1996: J Xu; T Tyan; E Cedrone; Niramol Savaraj; N Wang
Detection of 11q13 amplification as the origin of a homogeneously staining region in small cell lung cancer by chromosome microdissection.
Genes, chromosomes & cancer 1996;17(3):172-8.
1996: Lynn Feun; Niramol Savaraj; J Solomon; A Liebmann; Judith Hurley DeLeo
Phase II trial of mitoxantrone and cisplatin in advanced non-small-cell lung cancer.
American journal of clinical oncology 1996;19(2):190-2.
1995: Lynn Feun; William A Robinson; Niramol Savaraj; R Gonzalez; A Liebmann; K Offenhauser; N J Clendeninn
Phase II trial of piritrexim and DTIC using an alternating dose schedule in metastatic melanoma.
American journal of clinical oncology 1995;18(6):488-90.
1995: Lynn Feun; Niramol Savaraj; Frederick L Moffat; D Robinson; A Liebmann; Judith Hurley DeLeo; W A Raub; Stephen Richman
Phase II trial of recombinant interferon-alpha with BCNU, cisplatin, DTIC and tamoxifen in advanced malignant melanoma.
Melanoma research 1995;5(4):273-6.
1995: Danièle Brouty-Boyé; D Kolonias; C J Wu; Niramol Savaraj; Theodore J Lampidis
Relationship of multidrug resistance to rhodamine-123 selectivity between carcinoma and normal epithelial cells: taxol and vinblastine modulate drug efflux.
Cancer research 1995;55(8):1633-8.
1995: Peter A Cassileth; Eckhard R Podack; K Sridhar; Niramol Savaraj; J Hanlon
Phase I study of transfected cancer cells expressing the interleukin-2 gene product in limited stage small cell lung cancer.
Human gene therapy 1995;6(3):369-83.
1994: Lynn Feun; Niramol Savaraj; Pasquale Benedetto; S Waldman; M Collier; N J Clendennin
Oral piritrexim in advanced bladder cancer: an effective drug after progression on MVAC chemotherapy?
American journal of clinical oncology 1994;17(5):448-51.
1994: Lynn Feun; K R Reddy; Jose Yrizarry; Niramol Savaraj; Jorge Guerra; R K Purser; S Waldman; Joe U Levi; F Moffatt; L Morrell
A phase I study of chemoembolization with cisplatin and lipiodol for primary and metastatic liver cancer.
American journal of clinical oncology 1994;17(5):405-10.
1994: Lynn Feun; Niramol Savaraj; S Hung; R Reddy; Lennox Jeffers; Pasquale Benedetto; Alan Livingstone; Bach Ardalan; Joe U Levi; T Parker
A phase II trial of recombinant leukocyte interferon plus doxorubicin in patients with hepatocellular carcinoma.
American journal of clinical oncology 1994;17(5):393-5.
1994: J Y Zhao; Niramol Savaraj; R Song; Waldemar Priebe; M Tien Kuo
Overexpression of P-glycoprotein but not its mRNA in multidrug resistant cells selected with hydroxyrubicin.
Anticancer research 1994;14(5A):1735-42.
1994: Lynn Feun; W A Raub; Robert Duncan; Frederick L Moffat; Niramol Savaraj; A Nemeth; Arnold Markoe; Edward Trapido
Melanoma in a southeastern Hispanic population.
Cancer detection and prevention 1994;18(2):145-52.
1994: Niramol Savaraj; Theodore J Lampidis; J Y Zhao; C J Wu; L D Teeter; M Tien Kuo
Two multidrug-resistant Friend leukemic cell lines selected with different drugs exhibit overproduction of different P-glycoproteins.
Cancer investigation 1994;12(2):138-44.
1994: Lynn Feun; Niramol Savaraj; Howard Landy
Drug resistance in brain tumors.
Journal of neuro-oncology 1994;20(2):165-76.
1993: C C Cheng; Q Dong; D F Liu; Y L Luo; L F Liu; A Y Chen; C Yu; Niramol Savaraj; T C Chou
Design of antineoplastic agents on the basis of the "2-phenylnaphthalene-type" structural pattern. 2. Synthesis and biological activity studies of benzo]b]naphtho[2,3-d]furan-6,11-dione derivatives.
Journal of medicinal chemistry 1993;36(25):4108-12.
1993: T Hsu; Lynn Feun; Z Trizna; Niramol Savaraj; L Shirley; C Furlong; S Schantz; R Weber; T Shen; O Kucuk
Differential sensitivity among 3 human subpopulations in response to 4-nitroquinoline-1-oxide and to bleomycin.
International journal of oncology 1993;3(5):827-30.
1993: K S Sridhar; Richard J Thurer; Arnold Markoe; H T Chatoor; G Fountzilas; W J Raub; Niramol Savaraj; E J Beattie
Multidisciplinary approach to the treatment of locally and regionally advanced non-small cell lung cancer: University of Miami experience.
Seminars in surgical oncology 1993;9(2):114-9.
1993: Lynn Feun; G Blyden; Jose Yrizarry; M Dorvil; S Waldman; Pasquale Benedetto; E Donnelly; J Curtas; M George; Niramol Savaraj
Clinical and pharmacological study of intrahepatic artery infusion of thiotepa.
Cancer biotherapy 1993;8(1):43-8.
1993: Niramol Savaraj; Lynn Feun; G Blyden; Jose Yrizarry; J T Hsiang; J Curtas; S Waldman; J D Post; Pasquale Benedetto; Howard Landy
A pilot clinical and pharmacological study of intra-arterial infusion of thiotepa.
Cancer biotherapy 1993;8(1):37-42.
1992: M L Garcia Moore; Niramol Savaraj; Lynn Feun; E Donnelly
Successful therapy of peritoneal mesothelioma with intraperitoneal chemotherapy alone. A case report.
American journal of clinical oncology 1992;15(6):528-30.
1992: M Dellinger; B C Pressman; C Calderon-Higginson; Niramol Savaraj; Haim Tapiero; D Kolonias; Theodore J Lampidis
Structural requirements of simple organic cations for recognition by multidrug-resistant cells.
Cancer research 1992;52(22):6385-9.
1992: K S Sridhar; A M Hussein; Pasquale Benedetto; Bach Ardalan; Niramol Savaraj; Stephen Richman
Phase II trial of 4'-0-tetrahydropyranyladriamycin (pirarubicin) in head and neck carcinoma.
Cancer 1992;70(6):1591-7.
1992: Niramol Savaraj; Lynn Feun; K Lu; K Gray; C Wang; T L Loo
Pharmacology of intrathecal VP-16-213 in dogs.
Journal of neuro-oncology 1992;13(3):211-5.
1992: D Brouty-Boye; D Kolonias; Niramol Savaraj; Theodore J Lampidis
Alpha-smooth muscle actin expression in cultured cardiac fibroblasts of newborn rat.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1992;28A(4):293-6.
1992: Lynn Feun; Niramol Savaraj; J Bujnoski; S Nadeem
Spinal cord compression produced by osteomyelitis mimicking spinal epidural metastasis.
American journal of clinical oncology 1992;15(2):174-9.
1992: Theodore J Lampidis; D Kolonias; Niramol Savaraj; R W Rubin
Cardiostimulatory and antiarrhythmic activity of tubulin-binding agents.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1256-60.
1992: Bach Ardalan; K Stridhar; R Reddy; Pasquale Benedetto; Stephen Richman; S Waldman; L Morrell; Lynn Feun; Niramol Savaraj; Alan Livingstone
Phase I study of high dose 5-fluorouracil and high dose Leucovorin with low dose phosphonacetyl-L-aspartic acid in patients with advanced malignancies.
International journal of radiation oncology, biology, physics 1992;22(3):511-4.
1992: W A Raub; Lynn Feun; Robert Duncan; Frederick L Moffat; Niramol Savaraj; A Nemeth; Arnold Markoe
Descriptive analysis of the tumor registry experience for malignant melanoma from 1977 to 1986 at the University of Miami School of Medicine/Jackson Memorial Hospital.
Cancer detection and prevention 1992;16(3):193-201.
1991: Bach Ardalan; K S Sridhar; Pasquale Benedetto; Stephen Richman; S Waldman; L Morrell; Lynn Feun; Niramol Savaraj; M Fodor; Alan Livingstone
A phase I, II study of high-dose 5-fluorouracil and high-dose leucovorin with low-dose phosphonacetyl-L-aspartic acid in patients with advanced malignancies.
Cancer 1991;68(6):1242-6.
1991: K S Sridhar; A M Hussein; Pasquale Benedetto; S M Waldman; Lynn Feun; Niramol Savaraj; Stephen Richman; Bach Ardalan; P Desai
Phase II trial of mitoxantrone in head and neck carcinoma.
American journal of clinical oncology 1991;14(4):298-304.
1991: Lynn Feun; R Gonzalez; Niramol Savaraj; J Hanlon; M Collier; William A Robinson; N J Clendeninn
Phase II trial of piritrexim in metastatic melanoma using intermittent, low-dose administration.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1991;9(3):464-7.
1991: Lynn Feun; Niramol Savaraj; Pasquale Benedetto; J Hanlon; K S Sridhar; M Collier; Stephen Richman; S H Liao; N J Clendeninn
Phase I trial of piritrexim capsules using prolonged, low-dose oral administration for the treatment of advanced malignancies.
Journal of the National Cancer Institute 1991;83(1):51-5.
1991: Lynn Feun; J Albores-Saavedra; Niramol Savaraj
Osteogenic sarcoma arising adjacent to a long-standing ameloblastoma. A case report.
Oral surgery, oral medicine, and oral pathology 1991;71(1):77-9.
1991: Lynn Feun; Niramol Savaraj; Y Y Lee; Howard Landy; J Martinez-Prieto; C Charnsangavej; J D Post; K F Lee; S Wallace; Brian C Bowen
A pilot clinical and pharmacokinetic study of intracarotid cisplatin and bleomycin.
Selective cancer therapeutics 1991;7(1):29-36.
1990: K S Sridhar; T S Samy; Ram P Agarwal; Robert Duncan; Pasquale Benedetto; AWTAR KRISHAN; Charles L Vogel; Lynn Feun; Niramol Savaraj; Stephen Richman
A phase I study of 4'-0-tetrahydropyranyladriamycin. Clinical pharmacology and pharmacokinetics.
Cancer 1990;66(10):2082-91.
1990: Lynn Feun; Niramol Savaraj
Detection of occult bone metastasis by MRI scan.
The Journal of the Florida Medical Association 1990;77(10):881-3.
1990: Lynn Feun; Niramol Savaraj; Howard Landy; H Levin; Theodore J Lampidis
Phase II study of homoharringtonine in patients with recurrent primary malignant central nervous system tumors.
Journal of neuro-oncology 1990;9(2):159-63.
1990: Lynn Feun; Y Y Lee; Carl Plager; Nicholas Papadopoulos; Niramol Savaraj; C Charnsangavej; Robert S Benjamin; S Wallace
Intracarotid cisplatin-based chemotherapy in patients with malignant melanoma and central nervous system (CNS) metastases.
American journal of clinical oncology 1990;13(5):448-51.
1990: A M Hussein; Lynn Feun; Niramol Savaraj; D East; D T Hussein
Carcinoid tumor presenting as central nervous system symptoms. Case report and review of the literature.
American journal of clinical oncology 1990;13(3):251-5.
1990: Lynn Feun; M Maor; D J Stewart; M E Leavens; Niramol Savaraj; Gerald P Bodey
Pilot study of PCNU and cranial radiation therapy in the treatment of patients with malignant gliomas.
Oncology 1990;47(5):389-92.
1989: Theodore J Lampidis; C Castello; A del Giglio; B C Pressman; P Viallet; K W Trevorrow; G K Valet; Haim Tapiero; Niramol Savaraj
Relevance of the chemical charge of rhodamine dyes to multiple drug resistance.
Biochemical pharmacology 1989;38(23):4267-71.
1989: A M Hussein; Niramol Savaraj; Lynn Feun; Parvin Ganjei-Azar; E Donnelly
Carcinomatous meningitis from transitional cell carcinoma of the bladder: case report.
Journal of neuro-oncology 1989;7(3):255-60.
1989: Aldo N Serafini; J Kotler; Lynn Feun; M Dewanjee; D Robinson; D Salk; George N Sfakianakis; P Abrams; Niramol Savaraj; D Goodwin
Technetium-99m labeled monoclonal antibodies in the detection of metastatic melanoma.
Clinical nuclear medicine 1989;14(8):580-7.
1989: Niramol Savaraj; J Liang; K Lu; Lynn Feun; T C Hsu
Genotoxicity of [1H]benz[de]isoquinoline-1,3[2H]dione,5 amino-2-,[2-dimethylamino) ethyl] (BIDA) in human lymphocytes.
Cancer investigation 1989;7(2):117-21.
1988: Lynn Feun; Niramol Savaraj; Sewa S Legha; E G Silva; R S Benjamin; M A Burgess
Chemotherapy for metastatic Merkel cell carcinoma. Review of the M.D. Anderson Hospital's experience.
Cancer 1988;62(4):683-5.
1988: Clayton D Chong; C J Logothetis; Niramol Savaraj; H A Fritsche; A M Gietner; M L Samuels
The correlation of vinblastine pharmacokinetics to toxicity in testicular cancer patients.
Journal of clinical pharmacology 1988;28(8):714-8.
1988: K Lu; Niramol Savaraj; Lynn Feun; Z G Guo; T Umsawasdi; T L Loo
Pharmacokinetics of homoharringtonine in dogs.
Cancer chemotherapy and pharmacology 1988;21(2):139-42.
1987: J Khorsand; Ruth Katz; Niramol Savaraj
Malignant carcinoid of the pancreas: a cytologic, ultrastructural, and immunocytochemical study of a case diagnosed by fine-needle aspiration of a supraclavicular node metastasis.
Diagnostic cytopathology 1987;3(3):222-7.
1987: Niramol Savaraj; Lynn Feun; K Lu; M Leavens; R Moser; W S Fields; T L Loo
Central nervous system (CNS) penetration of homoharringtonine (HHT).
Journal of neuro-oncology 1987;5(1):77-81.
1987: Niramol Savaraj; K Lu; Lynn Feun; M A Burgess; T L Loo
Comparison of CNS penetration, tissue distribution, and pharmacology of VP 16-213 by intracarotid and intravenous administration in dogs.
Cancer investigation 1987;5(1):11-6.
1987: Lynn Feun; Y Y Lee; W K Yung; Niramol Savaraj; S Wallace
Intracarotid VP-16 in malignant brain tumors.
Journal of neuro-oncology 1987;4(4):397-401.
1987: Kenneth C Wright; L C Stephens; Sidney Wallace; Niramol Savaraj; Lynn Feun
Experimental combination chemotherapy: intracarotid versus intravenous administration of aziridinylbenzoquinone, BCNU, and cisplatin in dogs.
Chemotherapy 1987;33(6):437-44.
1987: Charles L Vogel; E Gorowski; E Davila; Mario A Eisenberger; J Kosinski; Ram P Agarwal; Niramol Savaraj
Phase I clinical trial and pharmacokinetics of weekly ICRF-187 (NSC 169780) infusion in patients with solid tumors.
Investigational new drugs 1987;5(2):187-98.
1986: Niramol Savaraj; K Lu; I Dimery; Lynn Feun; M Burgess; M Keating; T L Loo
Clinical pharmacology of homoharringtonine.
Cancer treatment reports 1986;70(12):1403-7.
1986: R Pasterz; Niramol Savaraj; M Burgess
Prognostic factors in metastatic carcinoma of unknown primary.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1986;4(11):1652-7.
1986: K Lu; Niramol Savaraj; B S Yap; Lynn Feun; T Umsawasdi; T L Loo
Clinical pharmacokinetics of 9, 10-anthracenedicarboxaldehyde-bis [(4,5-dihydro-1 H-imidazol-2-yl)hydrazone]dihydrochloride.
Cancer chemotherapy and pharmacology 1986;16(2):156-9.
1986: Lynn Feun; Y Y Lee; W K Yung; C Charnsangavej; Niramol Savaraj; R A Tang; S Wallace
Phase II trial of intracarotid BCNU and cisplatin in primary malignant brain tumors.
Cancer drug delivery 1986;3(2):147-56.
1986: Niramol Savaraj; Lynn Feun; K Lu; S Wallace; W S Fields; T L Loo
Clinical pharmacology of intracarotid etoposide.
Cancer chemotherapy and pharmacology 1986;16(3):292-4.
1986: K Lu; Niramol Savaraj; J Kavanagh; Lynn Feun; M Burgess; Gerald P Bodey; T L Loo
Clinical pharmacology of 4-demethoxydaunorubicin (DMDR).
Cancer chemotherapy and pharmacology 1986;17(2):143-8.
1985: K Lu; Niramol Savaraj; R A Newman
High-performance liquid chromatographic separation and quantitation of benzisoquinolinedione (Nafidimide) from biological fluids.
Journal of chromatography 1985;345(2):408-12.
1985: J J Kavanagh; K Y Yeung; Niramol Savaraj; I H Krakoff
Phase I clinical evaluation of oral and intravenous 4-demethoxydaunorubicin.
European journal of cancer & clinical oncology 1985;21(10):1187-9.
1985: L D Feldman; Lynn Feun; Robert S Benjamin; B S Yap; Carl Plager; Nicholas Papadopoulos; Niramol Savaraj; M A Burgess; Gerald P Bodey
A phase II trial of PCNU in patients with malignant melanoma and central nervous system metastases.
American journal of clinical oncology 1985;8(3):215-7.
1985: Lynn Feun; W K Yung; D J Stewart; Niramol Savaraj; Gerald P Bodey
Phase II trial of mitogauzone in malignant primary brain tumors.
Cancer treatment reports 1985;69(3):329-30.
1985: E A Obbens; Lynn Feun; M E Leavens; Niramol Savaraj; D J Stewart; J U Gutterman
Phase I clinical trial of intralesional or intraventricular leukocyte interferon for intracranial malignancies.
Journal of neuro-oncology 1985;3(1):61-7.
1985: Lynn Feun; Y Y Lee; S Wallace; C Charnsangavej; Niramol Savaraj; C H Carrasco; C Gianturco; W K Yung
New drugs and new delivery techniques.
Progress in experimental tumor research 1985;29():131-9.
1984: Lynn Feun; Niramol Savaraj; A T Ozarda
Cisplatin in medulloblastoma with extracranial metastasis: a case report.
Cancer treatment reports 1984;68(10):1307-9.
1984: Lynn Feun; S Wallace; D J Stewart; V P Chuang; W K Yung; M E Leavens; M A Burgess; Niramol Savaraj; Robert S Benjamin; S E Young
Intracarotid infusion of cis-diamminedichloroplatinum in the treatment of recurrent malignant brain tumors.
Cancer 1984;54(5):794-9.
1984: Lynn Feun; Niramol Savaraj; Gerald P Bodey; K Lu; B S Yap; J A Ajani; M A Burgess; Robert S Benjamin; E McKelvey; I Krakoff
Phase I study of tricyclic nucleoside phosphate using a five-day continuous infusion schedule.
Cancer research 1984;44(8):3608-12.
1984: K Lu; Niramol Savaraj; T L Loo
Pharmacological disposition of 1,4-dihydroxy-5-8-bis[[2 [(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride in the dog.
Cancer chemotherapy and pharmacology 1984;13(1):63-6.
1984: D J Stewart; G Zhengang; K Lu; Niramol Savaraj; Lynn Feun; M Luna; R S Benjamin; M J Keating; T L Loo
Human tissue distribution of 4'-(9-acridinylamino)-methanesulfon-m-anisidide (NSC 141549, AMSA).
Cancer chemotherapy and pharmacology 1984;12(2):116-9.
1984: Lynn Feun; S Wallace; W K Yung; Y Y Lee; M E Leavens; R Moser; Niramol Savaraj; M A Burgess; C Plager; R S Benjamin
Phase-I trial of intracarotid BCNU and cisplatin in patients with malignant intracerebral tumors.
Cancer drug delivery 1984;1(3):239-45.
1984: K C Wright; C Charnsangavej; S Wallace; V P Chuang; Niramol Savaraj
Regional isolation-perfusion: an experimental percutaneous approach tested and compared with arterial occlusion-infusion.
Cardiovascular and interventional radiology 1984;7(6):294-8.
1984: Lynn Feun; W K Yung; M E Leavens; M A Burgess; E A Obbens; A Y Bedikian; Niramol Savaraj; D J Stewart; Robert S Benjamin; W S Fields
A phase II trial of 2,5,-diaziridinyl 3,6-bis (carboethoxy amino) 1,4-benzoquinone (AZQ, NSC 182986) in recurrent primary brain tumors.
Journal of neuro-oncology 1984;2(1):13-7.
1983: K Lu; Niramol Savaraj; B S Yap; A Y Bedikian; Lynn Feun; Robert S Benjamin; T L Loo
Clinical pharmacology of 2,5'-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone (AZQ).
European journal of cancer & clinical oncology 1983;19(5):603-6.
1983: T L Loo; L Jiushi; K Lu; Niramol Savaraj
Clinical pharmacokinetics of 5-methyltetrahydrohomofolate.
Cancer research 1983;43(2):921-4.
1983: Z G Guo; Niramol Savaraj; Lynn Feun; K Lu; D J Stewart; M Luna; R S Benjamin; T L Loo
Tumor penetration of AMSA in man.
Cancer investigation 1983;1(6):475-8.
1983: Lynn Feun; Niramol Savaraj; K Lu; Z Guo; L G Raulston; R S Benjamin; W S Fields; T L Loo
The pharmacologic fate of 2,5-diaziridinyl-3,6-bis(carboethoxyamino) 1,4-benzoquinone (AZQ NSC-182986) by intracarotid or intravenous administration in beagles.
Journal of neuro-oncology 1983;1(3):219-24.
1983: Lynn Feun; D J Stewart; M E Leavens; M A Burgess; Niramol Savaraj; R S Benjamin; Gerald P Bodey
A phase II trial of 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea (PCNU, NSC 95466) in recurrent malignant brain tumors.
Journal of neuro-oncology 1983;1(1):45-8.
1983: Niramol Savaraj; K Lu; Lynn Feun; M E Leavens; D Stewart; M A Burgess; Robert S Benjamin; T L Loo
Intracerebral penetration and tissue distribution of 2,5-diaziridinyl 3,6-bis(carboethoxyamino) 1,4-benzoquinone (AZQ, NSC-182986).
Journal of neuro-oncology 1983;1(1):15-9.
1983: Lynn Feun; D J Stewart; M Maor; M Leavens; Niramol Savaraj; M A Burgess; W K Yung; Robert S Benjamin
A pilot study of cis-diamminedichloroplatinum and radiation therapy in patients with high grade astrocytomas.
Journal of neuro-oncology 1983;1(2):109-13.
1982: Niramol Savaraj; K Lu; Manuel Valdivieso; M Burgess; T Umsawasdi; R S Benjamin; T L Loo
Clinical kinetics of 1, 4-dihydroxy-5,8-bis [(2-[(2-hydroxyethyl) amino] ethyl] amino ]-9, 10-anthracenedione.
Clinical pharmacology and therapeutics 1982;31(3):312-6.
1982: Niramol Savaraj; K Lu; V Manuel; T L Loo
Pharmacology of mitoxantrone in cancer patients.
Cancer chemotherapy and pharmacology 1982;8(1):113-7.
1981: Manuel Valdivieso; A Y Bedikian; M A Burgess; Niramol Savaraj; W B Jeffers; Gerald P Bodey
Phase I clinical study of dihydroxyanthracenedione administered on a 5-day iv schedule.
Cancer treatment reports 1981;65(9-10):841-4.
1981: Eric C-Y Lian; Niramol Savaraj
Effects of platelet inhibitors on the platelet aggregation induced by plasma from patients with thrombotic thrombocytopenic purpura.
Blood 1981;58(2):354-9.
1980: Niramol Savaraj; L M Allen; C Sutton; M Troner
Immunological modification of adriamycin cardiotoxicity.
Research communications in chemical pathology and pharmacology 1980;29(3):549-59.
1980: Niramol Savaraj; M B Troner
Aminoglutethimide in the management of metastatic breast cancer.
Medical and pediatric oncology 1980;8(3):251-63.