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John Savarese

Research Profile

Chemicals & Drugs

Anatomy

Neuromuscular Junction

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Disorders

Physiology

Phenomena

Muscle Contraction

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Anesthesia

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Publications

TOP 3
Paul M Heerdt; Jaideep K Malhotra; Brian Y Pan; Hiroshi Sunaga; John J Savarese
Pharmacodynamics and cardiopulmonary side effects of CW002, a cysteine-reversible neuromuscular blocking drug in dogs.
Hiroshi Sunaga; Jaideep K Malhotra; Edward Yoon; John J Savarese; Paul M Heerdt
Cysteine reversal of the novel neuromuscular blocking drug CW002 in dogs: pharmacodynamics, acute cardiovascular effects, and preliminary toxicology.
Paul M Heerdt; Richard Kang; Andrew The'; Mir A Hashim; Robert J Mook; John J Savarese
Cardiopulmonary effects of the novel neuromuscular blocking drug GW280430A (AV430A) in dogs.

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All Publications

2010: Paul M Heerdt; Jaideep K Malhotra; Brian Y Pan; Hiroshi Sunaga; John J Savarese
Pharmacodynamics and cardiopulmonary side effects of CW002, a cysteine-reversible neuromuscular blocking drug in dogs.
Anesthesiology 2010;112(4):910-6.
2010: Hiroshi Sunaga; Jaideep K Malhotra; Edward Yoon; John J Savarese; Paul M Heerdt
Cysteine reversal of the novel neuromuscular blocking drug CW002 in dogs: pharmacodynamics, acute cardiovascular effects, and preliminary toxicology.
Anesthesiology 2010;112(4):900-9.
2004: Paul M Heerdt; Richard Kang; Andrew The'; Mir A Hashim; Robert J Mook; John J Savarese
Cardiopulmonary effects of the novel neuromuscular blocking drug GW280430A (AV430A) in dogs.
Anesthesiology 2004;100(4):846-51.
2004: John J Savarese; Matthew R Belmont; Mir A Hashim; Robert A Mook; Eric E Boros; Vicente Samano; Sanjay Patel; Paul L Feldman; Jan-Ake I Schultz; Michael McNulty; Timothy Spitzer; Douglas L Cohn; Philip Morgan; William B Wastila
Preclinical pharmacology of GW280430A (AV430A) in the rhesus monkey and in the cat: a comparison with mivacurium.
Anesthesiology 2004;100(4):835-45.
2004: Matthew R Belmont; Cynthia A Lien; Joseph Tjan; Eleanor Bradley; Brenna Stein; Sanjay Patel; John J Savarese
Clinical pharmacology of GW280430A in humans.
Anesthesiology 2004;100(4):768-73.
2003: Takahiro Suzuki; Cynthia A Lien; Matthew R Belmont; Joseph Tjan; John J Savarese
Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium.
Canadian journal of anaesthesia = Journal canadien d'anesthésie 2003;50(9):879-85.
2003: Eric E Boros; Vicente Samano; John A Ray; James B Thompson; David K Jung; Istvan Kaldor; Cecilia S Koble; Michael T Martin; Virgil L Styles; Robert A Mook; Paul L Feldman; John J Savarese; Matthew R Belmont; Eric C Bigham; G Evan Boswell; Mir A Hashim; Sanjay Patel; James C Wisowaty; Gary D Bowers; Caroline L Moseley; John S Walsh; Mindy J Reese; Randy D Rutkowske; Andrea M Sefler; Timothy D Spitzer
Neuromuscular blocking activity and therapeutic potential of mixed-tetrahydroisoquinolinium halofumarates and halosuccinates in rhesus monkeys.
Journal of medicinal chemistry 2003;46(12):2502-15.
1999: Cynthia A Lien; Matthew R Belmont; D L Wray Roth; M Okamoto; A Abalos; John J Savarese
Pharmacodynamics and the plasma concentration of mivacurium during spontaneous recovery and neostigmine-facilitated recovery.
Anesthesiology 1999;91(1):119-26.
1999: Cynthia A Lien; Matthew R Belmont; A Abalos; D Hass; John J Savarese
The nature of spontaneous recovery from mivacurium-induced neuromuscular block.
Anesthesia and analgesia 1999;88(3):648-53.
1999: Eric E Boros; Eric C Bigham; G Evan Boswell; Robert A Mook; Sanjay Patel; John J Savarese; John A Ray; James B Thompson; Mir A Hashim; James C Wisowaty; Paul L Feldman; Vicente Samano
Bis- and mixed-tetrahydroisoquinolinium chlorofumarates: new ultra-short-acting nondepolarizing neuromuscular blockers.
Journal of medicinal chemistry 1999;42(2):206-9.
1997: John J Savarese; Cynthia A Lien; Matthew R Belmont; W B Wastila
[The clinical pharmacology of new benzylisoquinoline-diester compounds, with special consideration of cisatracurium and mivacurium].
Der Anaesthesist 1997;46(10):840-9.
1997: F S Yao; John J Savarese
Pseudocholinesterase hyperactivity with succinylcholine resistance: an unusual cause of difficult intubation.
Journal of clinical anesthesia 1997;9(4):328-30.
1996: W B Wastila; R B Maehr; G L Turner; D A Hill; John J Savarese
Comparative pharmacology of cisatracurium (51W89), atracurium, and five isomers in cats.
Anesthesiology 1996;85(1):169-77.
1996: John J Savarese; Cynthia A Lien; Matthew R Belmont
Antagonism of residual mivacurium blockade: setting the record straight.
Anesthesiology 1996;84(6):1525-8.
1996: Cynthia A Lien; V D Schmith; Matthew R Belmont; A Abalos; David Kisor; John J Savarese
Pharmacokinetics of cisatracurium in patients receiving nitrous oxide/opioid/barbiturate anesthesia.
Anesthesiology 1996;84(2):300-8.
1995: Matthew R Belmont; Cynthia A Lien; S Quessy; M M Abou-Donia; A Abalos; L Eppich; John J Savarese
The clinical neuromuscular pharmacology of 51W89 in patients receiving nitrous oxide/opioid/barbiturate anesthesia.
Anesthesiology 1995;82(5):1139-45.
1995: Cynthia A Lien; Matthew R Belmont; A Abalos; L Eppich; S Quessy; M M Abou-Donia; John J Savarese
The cardiovascular effects and histamine-releasing properties of 51W89 in patients receiving nitrous oxide/opioid/barbiturate anesthesia.
Anesthesiology 1995;82(5):1131-8.
1995: John J Savarese; W B Wastila
The future of the benzylisoquinolinium relaxants.
Acta anaesthesiologica Scandinavica. Supplementum 1995;106():91-3.
1995: John J Savarese; Cynthia A Lien; Matthew R Belmont; L Rubin
The clinical and basic pharmacology of mivacurium: a short-acting nondepolarizing benzylisoquinolinium diester neuromuscular blocking drug.
Acta anaesthesiologica Scandinavica. Supplementum 1995;106():18-22.
1995: John J Savarese; Cynthia A Lien; Matthew R Belmont
The accuracy of the 5%-25% (T1-T3) twitch recovery interval in predicting the speed of spontaneous recovery from mivacurium-induced neuromuscular blockade.
Anesthesia and analgesia 1995;80(1):209-10.
1994: N G Goudsouzian; John J Savarese
Antagonizing residual neuromuscular block with neostigmine and atropine.
British journal of anaesthesia 1994;73(5):725.
1994: Cynthia A Lien; V D Schmith; P B Embree; Matthew R Belmont; W A Wargin; John J Savarese
The pharmacokinetics and pharmacodynamics of the stereoisomers of mivacurium in patients receiving nitrous oxide/opioid/barbiturate anesthesia.
Anesthesiology 1994;80(6):1296-302.
1993: Cynthia A Lien; Farida Gadalla; T T Kudlak; P B Embree; G J Sharp; John J Savarese
The effect of ondansetron on atracurium-induced neuromuscular blockade.
Journal of clinical anesthesia 1993;5(5):399-403.
1993: R E Kelly; Cynthia A Lien; John J Savarese; Matthew R Belmont; Gregg S Hartman; J R Russo; C Hollmann
Depression of neuromuscular function in a patient during desflurane anesthesia.
Anesthesia and analgesia 1993;76(4):868-71.
1990: D L Dresner; S J Basta; H H Ali; A F Schwartz; P B Embree; W A Wargin; A A Lai; K A Brady; John J Savarese
Pharmacokinetics and pharmacodynamics of doxacurium in young and elderly patients during isoflurane anesthesia.
Anesthesia and analgesia 1990;71(5):498-502.
1989: John J Savarese; H H Ali; S J Basta; R P Scott; P B Embree; W B Wastila; M M Abou-Donia; C Gelb
The cardiovascular effects of mivacurium chloride (BW B1090U) in patients receiving nitrous oxide-opiate-barbiturate anesthesia.
Anesthesiology 1989;70(3):386-94.
1989: NG Goudsouzian; J K Alifimoff; L M Liu; V Foster; B McNulty; John J Savarese
Neuromuscular and cardiovascular effects of doxacurium in children anaesthetized with halothane.
British journal of anaesthesia 1989;62(3):263-8.
1989: NG Goudsouzian; J K Alifimoff; C Eberly; R Smeets; J Griswold; V Miler; B F McNulty; John J Savarese
Neuromuscular and cardiovascular effects of mivacurium in children.
Anesthesiology 1989;70(2):237-42.
1988: H H Ali; John J Savarese; P B Embree; S J Basta; R G Stout; L H Bottros; J N Weakly
Clinical pharmacology of mivacurium chloride (BW B1090U) infusion: comparison with vecuronium and atracurium.
British journal of anaesthesia 1988;61(5):541-6.
1988: S J Basta; John J Savarese; H H Ali; P B Embree; A F Schwartz; G D Rudd; W B Wastila
Clinical pharmacology of doxacurium chloride. A new long-acting nondepolarizing muscle relaxant.
Anesthesiology 1988;69(4):478-86.
1988: D R Goldhill; P B Embree; H H Ali; John J Savarese
Reversal of pancuronium. Neuromuscular and cardiovascular effects of a mixture of neostigmine and glycopyrronium.
Anaesthesia 1988;43(6):443-6.
1988: John J Savarese; H H Ali; S J Basta; P B Embree; R P Scott; N Sunder; J N Weakly; W B Wastila; H A el-Sayad
The clinical neuromuscular pharmacology of mivacurium chloride (BW B1090U). A short-acting nondepolarizing ester neuromuscular blocking drug.
Anesthesiology 1988;68(5):723-32.
1986: R P Scott; John J Savarese; S J Basta; P Embree; H H Ali; N Sunder; D C Hoaglin
Clinical pharmacology of atracurium given in high dose.
British journal of anaesthesia 1986;58(8):834-8.
1986: F M deBros; A Lai; R Scott; J deBros; A G Batson; N Goudsouzian; H H Ali; A B Cosimi; John J Savarese
Pharmacokinetics and pharmacodynamics of atracurium during isoflurane anesthesia in normal and anephric patients.
Anesthesia and analgesia 1986;65(7):743-6.
1985: R P Scott; John J Savarese; S J Basta; N Sunder; H H Ali; M Gargarian; M Gionfriddo; A G Batson
Atracurium: clinical strategies for preventing histamine release and attenuating the haemodynamic response.
British journal of anaesthesia 1985;57(6):550-3.
1983: John J Savarese; H H Ali; S J Basta; N Sunder; J Moss; M A Gionfriddo; C G Lineberry; W B Wastila; H A El-Sayad; D Montague; L Braswell
The clinical pharmacology of BW A444U. A nondepolarizing ester relaxant of intermediate duration.
Anesthesiology 1983;58(4):333-41.
1983: S J Basta; John J Savarese; H H Ali; J Moss; M Gionfriddo
Histamine-releasing potencies of atracurium, dimethyl tubocurarine and tubocurarine.
British journal of anaesthesia 1983;55 Suppl 1():105S-106S.
1983: H H Ali; John J Savarese; S J Basta; N Sunder; M Gionfriddo
Evaluation of cumulative properties of three new nondepolarizing neuromuscular blocking drugs BW A444U, atracurium and vecuronium.
British journal of anaesthesia 1983;55 Suppl 1():107S-111S.
1982: S J Basta; H H Ali; John J Savarese; N Sunder; M Gionfriddo; G Cloutier; C Lineberry; A E Cato
Clinical pharmacology of atracurium besylate (BW 33A): a new non-depolarizing muscle relaxant.
Anesthesia and analgesia 1982;61(9):723-9.
1982: J Moss; D M Philbin; Carl E Rosow; S J Basta; C Gelb; John J Savarese
Histamine release by neuromuscular blocking agents in man.
Klinische Wochenschrift 1982;60(17):891-5.
1982: J A Martyn; R S Matteo; D J Greenblatt; Philip Lebowitz; John J Savarese
Pharmacokinetics of d-tubocurarine in patients with thermal injury.
Anesthesia and analgesia 1982;61(3):241-6.
1982: Carl E Rosow; J Moss; D M Philbin; John J Savarese
Histamine release during morphine and fentanyl anesthesia.
Anesthesiology 1982;56(2):93-6.
1981: D M Philbin; J Moss; C W Akins; Carl E Rosow; K Kono; R C Schneider; T R VerLee; John J Savarese
The use of H1 and H2 histamine antagonists with morphine anesthesia: a double-blind study.
Anesthesiology 1981;55(3):292-6.
1981: J Moss; Carl E Rosow; John J Savarese; D M Philbin; K J Kniffen
Role of histamine in the hypotensive action of d-tubocurarine in humans.
Anesthesiology 1981;55(1):19-25.
1981: H H Ali; John J Savarese; Philip Lebowitz; F M Ramsey
Twitch, tetanus and train-of-four as indices of recovery from nondepolarizing neuromuscular blockade.
Anesthesiology 1981;54(4):294-7.
1981: Philip Lebowitz; F M Ramsey; John J Savarese; H H Ali; F M deBros
Combination of pancuronium and metocurine: neuromuscular and hemodynamic advantages over pancuronium alone.
Anesthesia and analgesia 1981;60(1):12-7.
1980: J V Donlon; John J Savarese; H H Ali; R S Teplik
Human dose-response curves for neuromuscular blocking drugs: a comparison of two methods of construction and analysis.
Anesthesiology 1980;53(2):161-6.
1980: Philip Lebowitz; F M Ramsey; John J Savarese; H H Ali
Potentiation of neuromuscular blockade in man produced by combinations of pancuronium and metocurine or pancuronium and d-tubocurarine.
Anesthesia and analgesia 1980;59(8):604-9.
1980: J A Martyn; S K Szyfelbein; H H Ali; R S Matteo; John J Savarese
Increased d-tubocurarine requirement following major thermal injury.
Anesthesiology 1980;52(4):352-5.
1980: F M Ramsey; Philip Lebowitz; John J Savarese; H H Ali
Clinical characteristics of long-term succinylcholine neuromuscular blockade during balanced anesthesia.
Anesthesia and analgesia 1980;59(2):110-6.
1980: H H Ali; John J Savarese
Stimulus frequency and dose-respone curve to d-tubocurarine in man.
Anesthesiology 1980;52(1):36-9.
1980: Philip Lebowitz; John J Savarese
Complications involving neuromuscular pharmacology.
International anesthesiology clinics 1980;18(3):139-56.