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Alexei Savchenko

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Hongyan Zheng; Wayne F Anderson; Alina Beliavsky; Greg Brown; Joseph S. Brunzelle; Elena Evdokimova; Robert Flick; Radhakrishnan Mahadevan; Alexei Savchenko; Anatoli Tchigvintsev; Zdzislaw Wawrzak; Alexander F Yakunin
Structure and activity of the NAD(P)(+) -dependent succinate semialdehyde dehydrogenase YneI from Salmonella typhimurium.
Alex U Singer; Tatiana Skarina; Tharan Srikumar; Xiaohui Xu; Hong Cui; Monique Egler; Lennart Eschen-Lippold; Justin Lee; Brian Raught; Alexei Savchenko; Dierk Scheel; Sebastian Schulze; Ulla Bonas
A pathogen type III effector with a novel E3 ubiquitin ligase architecture.
Andrei S Halavaty; Andrzej Joachimiak; Youngchang Kim; Keehwan Kwon; George Minasov; Olena Onopriyenko; Leka Papazisi; Scott N Peterson; Alexei Savchenko; Ludmilla Shuvalova; Tatiana Skarina; James Winsor; Min Zhou; Ievgeniia Dubrovska; Wayne F Anderson
Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteria.

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All Publications

2013: Hongyan Zheng; Wayne F Anderson; Alina Beliavsky; Greg Brown; Joseph S. Brunzelle; Elena Evdokimova; Robert Flick; Radhakrishnan Mahadevan; Alexei Savchenko; Anatoli Tchigvintsev; Zdzislaw Wawrzak; Alexander F Yakunin
Structure and activity of the NAD(P)(+) -dependent succinate semialdehyde dehydrogenase YneI from Salmonella typhimurium.
Proteins 2013;81(6):1031-41.
2013: Alex U Singer; Tatiana Skarina; Tharan Srikumar; Xiaohui Xu; Hong Cui; Monique Egler; Lennart Eschen-Lippold; Justin Lee; Brian Raught; Alexei Savchenko; Dierk Scheel; Sebastian Schulze; Ulla Bonas
A pathogen type III effector with a novel E3 ubiquitin ligase architecture.
PLoS pathogens 2013;9(1):e1003121.
2012: Andrei S Halavaty; Andrzej Joachimiak; Youngchang Kim; Keehwan Kwon; George Minasov; Olena Onopriyenko; Leka Papazisi; Scott N Peterson; Alexei Savchenko; Ludmilla Shuvalova; Tatiana Skarina; James Winsor; Min Zhou; Ievgeniia Dubrovska; Wayne F Anderson
Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteria.
Acta crystallographica. Section D, Biological crystallography 2012;68(Pt 10):1359-70.
2012: I G Shabalin; O Onopriyenko; P J Porebski; Alexei Savchenko; Maksymilian Chruszcz; David R Cooper; M Grabowski; S Grimshaw; Wladek Minor
Structure of anabolic ornithine carbamoyltransferase from Campylobacter jejuni at 2.7 Å resolution.
Acta crystallographica. Section F, Structural biology and crystallization communications 2012;68(Pt 9):1018-24.
2012: Sofia Lemak; Pierre Petit; Richard Reinhardt; Alexei Savchenko; Alexander U Singer; Anatoli Tchigvintsev; Michail M Yakimov; Greg Brown; Tatyana N Chernikova; Olga Egorova; Elena Evdokimova; Robert Flick; Peter N Golyshin; Claudio F Gonzalez; Michael Kube; Alexander F Yakunin
Structure and activity of the cold-active and anion-activated carboxyl esterase OLEI01171 from the oil-degrading marine bacterium Oleispira antarctica.
The Biochemical journal 2012;445(2):193-203.
2012: Claudio F Gonzalez; Andrzej Joachimiak; Susan Lynch; Jerzy Osipiuk; Alexei Savchenko; Anatoli Tchigvintsev; Xiaohui Xu; Greg Brown; Marianne E Cuff; Elena Evdokimova; Robert Flick; Alexander F Yakunin
Structure and activity of the Pseudomonas aeruginosa hotdog-fold thioesterases PA5202 and PA2801.
The Biochemical journal 2012;444(3):445-55.
2012: Jing Hou; Haibin Luo; Maksymilian Chruszcz; David R Cooper; Marcin Cymborowski; Elena Gordon; Alexei Savchenko; Tatiana Skarina; Kamila Wojciechowska; Heping Zheng; Wladek Minor
Structure of a short-chain dehydrogenase/reductase from Bacillus anthracis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2012;68(Pt 6):632-7.
2012: Heping Zheng; Wayne F Anderson; Maksymilian Chruszcz; Piotr Dworzynski; Ekaterina V Filippova; Sarah Grimshaw; Marina Kudritska; Olena Onopriyenko; Przemyslaw J Porebski; Alexei Savchenko; Karolina L Tkaczuk; Zdzislaw Wawrzak; Wladek Minor
Crystal structures of putative phosphoglycerate kinases from B. anthracis and C. jejuni.
Journal of structural and functional genomics 2012;13(1):15-26.
2012: Anna M Goral; Olga Kagan; Alexei Savchenko; Karolina L Tkaczuk; Maksymilian Chruszcz; Wladek Minor
Crystal structure of a putative isochorismatase hydrolase from Oleispira antarctica.
Journal of structural and functional genomics 2012;13(1):27-36.
2012: Przemyslaw J Porebski; Alexei Savchenko; Xiaohui Xu; Garib N Murshudov; Krzysztof Murzyn; Robert A Nicholls; Maksymilian Chruszcz; Marianne E Cuff; Marcin Cymborowski; Aled Edwards; Maria Klimecka; Wladek Minor
Structural characterization of Helicobacter pylori dethiobiotin synthetase reveals differences between family members.
The FEBS journal 2012;279(6):1093-105.
2012: Anatoli Tchigvintsev; Greg Brown; Elena Evdokimova; Robert Flick; Claudio F Gonzalez; Alexei Savchenko; Alexander Singer; Kemin Tan; Alexander F Yakunin
Biochemical and structural studies of uncharacterized protein PA0743 from Pseudomonas aeruginosa revealed NAD+-dependent L-serine dehydrogenase.
The Journal of biological chemistry 2012;287(3):1874-83.
2011: Ekaterina V Filippova; Jun Gu; Maksymilian Chruszcz; Marcin Cymborowski; Aled Edwards; Alexei Savchenko; Wladek Minor
Crystal structure of a putative transcriptional regulator SCO0520 from Streptomyces coelicolor A3(2) reveals an unusual dimer among TetR family proteins.
Journal of structural and functional genomics 2011;12(3):149-57.
2011: Maria M Klimecka; Lukasz Lebioda; Maksymilian Chruszcz; Marcin Cymborowski; Aled Edwards; Jose Font; Ian J Glomski; Jeremy Hasseman; Olena Onopryienko; Przemyslaw J Porebski; Alexei Savchenko; Igor Shumilin; Tatiana Skarina; Matthew D Zimmerman; Wladek Minor
Structural analysis of a putative aminoglycoside N-acetyltransferase from Bacillus anthracis.
Journal of molecular biology 2011;410(3):411-23.
2011: Anatoli Tchigvintsev; Greg Brown; Elena Evdokimova; Robert Flick; Pierre Petit; Alexei Savchenko; Alexander U Singer; Alexander F Yakunin
Structure and activity of the Saccharomyces cerevisiae dUTP pyrophosphatase DUT1, an essential housekeeping enzyme.
The Biochemical journal 2011;437(2):243-53.
2011: Jerzy Osipiuk; Xiaohui Xu; Hong Cui; Alexei Savchenko; Aled Edwards; Andrzej Joachimiak
Crystal structure of secretory protein Hcp3 from Pseudomonas aeruginosa.
Journal of structural and functional genomics 2011;12(1):21-6.
2011: Peter J Stogios; Tushar Shakya; Elena Evdokimova; Alexei Savchenko; Gerard D Wright
Structure and function of APH(4)-Ia, a hygromycin B resistance enzyme.
The Journal of biological chemistry 2011;286(3):1966-75.
2011: Kin-Kwan Lai; Sara Molloy; Alexei Savchenko; Peter J Stogios; Clara Vu; Xiaohui Xu; Alexander Yakunin; Hong Cui; Claudio F Gonzalez
An inserted α/β subdomain shapes the catalytic pocket of Lactobacillus johnsonii cinnamoyl esterase.
PloS one 2011;6(8):e23269.
2011: Mohan Babu; Natalia Beloglazova; Robert Flick; Chris Graham; Tatiana Skarina; Boguslaw Nocek; Alla Gagarinova; Oxana Pogoutse; Greg Brown; Andrew Binkowski; Sadhna Phanse; Andrzej Joachimiak; Eugene V Koonin; Alexei Savchenko; Andrew Emili; Jack Greenblatt; Aled M Edwards; Alexander F Yakunin
A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair.
Molecular microbiology 2011;79(2):484-502.
2010: Anatoli Tchigvintsev; Xiaohui Xu; Alexander Singer; Changsoo Chang; Greg Brown; Michael Proudfoot; Hong Cui; Robert Flick; Wayne F Anderson; Andrzej Joachimiak; Michael Galperin; Alexei Savchenko; Alexander F Yakunin
Structural insight into the mechanism of c-di-GMP hydrolysis by EAL domain phosphodiesterases.
Journal of molecular biology 2010;402(3):524-38.
2010: William Wiley Navarre; S Betty Zou; Hervé Roy; Jinglin Lucy Xie; Alexei Savchenko; Alexander Singer; Elena Edvokimova; Lynne R Prost; Runjun Kumar; Michael Ibba; Ferric C Fang
PoxA, yjeK, and elongation factor P coordinately modulate virulence and drug resistance in Salmonella enterica.
Molecular cell 2010;39(2):209-21.
2010: Zhou Yu; Sean E Reichheld; Alexei Savchenko; John Parkinson; Alan R Davidson
A comprehensive analysis of structural and sequence conservation in the TetR family transcriptional regulators.
Journal of molecular biology 2010;400(4):847-64.
2010: Ekaterina Kuznetsova; Linda Xu; Alexander Singer; Greg Brown; Aiping Dong; Robert Flick; Hong Cui; Marianne Cuff; Andrzej Joachimiak; Alexei Savchenko; Alexander F Yakunin
Structure and activity of the metal-independent fructose-1,6-bisphosphatase YK23 from Saccharomyces cerevisiae.
The Journal of biological chemistry 2010;285(27):21049-59.
2010: Bin Wu; Tatiana Skarina; Adelinda Yee; Marie-Claude Jobin; Rosa Dileo; Anthony Semesi; Christophe Fares; Alexander Lemak; Brian K Coombes; Cheryl H Arrowsmith; Alexander U Singer; Alexei Savchenko
NleG Type 3 effectors from enterohaemorrhagic Escherichia coli are U-Box E3 ubiquitin ligases.
PLoS pathogens 2010;6(6):e1000960.
2009: Shuren Wang; Olga Kirillova; Maksymilian Chruszcz; Dominik Gront; Matthew D Zimmerman; Marcin Cymborowski; Igor A Shumilin; Tatiana Skarina; Elena Gorodichtchenskaia; Alexei Savchenko; Aled M Edwards; Wladek Minor
The crystal structure of the AF2331 protein from Archaeoglobus fulgidus DSM 4304 forms an unusual interdigitated dimer with a new type of alpha + beta fold.
Protein science : a publication of the Protein Society 2009;18(11):2410-9.
2009: Greg Brown; Alexander Singer; Vladimir V Lunin; Michael Proudfoot; Tatiana Skarina; Robert Flick; Samvel Kochinyan; Ruslan Sanishvili; Andrzej Joachimiak; Aled M Edwards; Alexei Savchenko; Alexander F Yakunin
Structural and biochemical characterization of the type II fructose-1,6-bisphosphatase GlpX from Escherichia coli.
The Journal of biological chemistry 2009;284(6):3784-92.
2008: Alexander U Singer; John R Rohde; Robert Lam; Tatiana Skarina; Olga Kagan; Rosa Dileo; Nickolay Y Chirgadze; Marianne E Cuff; Andrzej Joachimiak; Mike Tyers; Philippe J Sansonetti; Claude Parsot; Alexei Savchenko
Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases.
Nature structural & molecular biology 2008;15(12):1293-301.
2008: Boguslaw Nocek; Samvel Kochinyan; Michael Proudfoot; Greg Brown; Elena Evdokimova; Jerzy Osipiuk; Aled M Edwards; Alexei Savchenko; Andrzej Joachimiak; Alexander F Yakunin
Polyphosphate-dependent synthesis of ATP and ADP by the family-2 polyphosphate kinases in bacteria.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(46):17730-5.
2008: Natalia Beloglazova; Greg Brown; Matthew D Zimmerman; Michael Proudfoot; Kira S Makarova; Marina Kudritska; Samvel Kochinyan; Shuren Wang; Maksymilian Chruszcz; Wladek Minor; Eugene V Koonin; Aled M Edwards; Alexei Savchenko; Alexander F Yakunin
A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats.
The Journal of biological chemistry 2008;283(29):20361-71.
2008: Greg Brown; Alex Singer; Michael Proudfoot; Tatiana Skarina; Youngchang Kim; Changsoo Chang; Irina Dementieva; Ekaterina Kuznetsova; Claudio F Gonzalez; Andrzej Joachimiak; Alexei Savchenko; Alexander F Yakunin
Functional and structural characterization of four glutaminases from Escherichia coli and Bacillus subtilis.
Biochemistry 2008;47(21):5724-35.
2007: Alexei Savchenko; Michael Proudfoot; Tatiana Skarina; Alexander Singer; Olga Litvinova; Ruslan Sanishvili; Greg Brown; Nickolay Chirgadze; Alexander F Yakunin
Molecular basis of the antimutagenic activity of the house-cleaning inosine triphosphate pyrophosphatase RdgB from Escherichia coli.
Journal of molecular biology 2007;374(4):1091-103.
2007: Bogi Nocek; Elena Evdokimova; Michael Proudfoot; M Kudritska; L L Grochowski; R H White; Alexei Savchenko; Alexander F Yakunin; Aled Edwards; Andrzej Joachimiak
Structure of an amide bond forming F(420):gamma-glutamyl ligase from Archaeoglobus fulgidus -- a member of a new family of non-ribosomal peptide synthases.
Journal of molecular biology 2007;372(2):456-69.
2007: Janusz J Petkowski; Maksymilian Chruszcz; Matthew D Zimmerman; Heping Zheng; Tatiana Skarina; Olena Onopriyenko; Marcin Cymborowski; Katarzyna D Koclega; Alexei Savchenko; Aled Edwards; Wladek Minor
Crystal structures of TM0549 and NE1324--two orthologs of E. coli AHAS isozyme III small regulatory subunit.
Protein science : a publication of the Protein Society 2007;16(7):1360-7.
2007: Darcie J Miller; Ludmilla Shuvalova; Elena Evdokimova; Alexei Savchenko; Alexander F Yakunin; Wayne F Anderson
Structural and biochemical characterization of a novel Mn2+-dependent phosphodiesterase encoded by the yfcE gene.
Protein science : a publication of the Protein Society 2007;16(7):1338-48.
2007: Graciela L Lorca; Alexandra Ezersky; Vladimir V Lunin; John R Walker; Svetlana M Altamentova; Elena Evdokimova; Masoud Vedadi; Alexey Bochkarev; Alexei Savchenko
Glyoxylate and pyruvate are antagonistic effectors of the Escherichia coli IclR transcriptional regulator.
The Journal of biological chemistry 2007;282(22):16476-91.
2007: James D Watson; Steve Sanderson; Alexandra Ezersky; Alexei Savchenko; Aled Edwards; Christine Orengo; Andrzej Joachimiak; Roman A Laskowski; Janet M Thornton
Towards fully automated structure-based function prediction in structural genomics: a case study.
Journal of molecular biology 2007;367(5):1511-22.
2007: Yuhong Zuo; Heping Zheng; Yong Wang; Maksymilian Chruszcz; Marcin Cymborowski; Tatiana Skarina; Alexei Savchenko; Arun Malhotra; Wladek Minor
Crystal structure of RNase T, an exoribonuclease involved in tRNA maturation and end turnover.
Structure (London, England : 1993) 2007;15(4):417-28.
2007: Olga Kirillova; Maksymilian Chruszcz; Igor A Shumilin; Tatiana Skarina; Elena Gorodichtchenskaia; Marcin Cymborowski; Alexei Savchenko; Aled Edwards; Wladek Minor
An extremely SAD case: structure of a putative redox-enzyme maturation protein from Archaeoglobus fulgidus at 3.4 A resolution.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 3):348-54.
2007: Edyta A L Sieminska; Xiaohui Xu; Alexei Savchenko; David A R Sanders
The X-ray crystal structure of PA1607 from Pseudomonas aureginosa at 1.9 A resolution--a putative transcription factor.
Protein science : a publication of the Protein Society 2007;16(3):543-9.
2007: Dmitry V Lesnyak; Jerzy Osipiuk; Tatiana Skarina; Petr V Sergiev; Alexey A Bogdanov; Aled Edwards; Alexei Savchenko; Andrzej Joachimiak; Olga A Dontsova
Methyltransferase that modifies guanine 966 of the 16 S rRNA: functional identification and tertiary structure.
The Journal of biological chemistry 2007;282(8):5880-7.
2006: Marina Gorelik; Vladimir V Lunin; Tatiana Skarina; Alexei Savchenko
Structural characterization of GntR/HutC family signaling domain.
Protein science : a publication of the Protein Society 2006;15(6):1506-11.
2006: Bogi Nocek; Marianne E Cuff; Elena Evdokimova; Aled Edwards; Andrzej Joachimiak; Alexei Savchenko
1.6 A crystal structure of a PA2721 protein from pseudomonas aeruginosa--a potential drug-resistance protein.
Proteins 2006;63(4):1102-5.
2006: John R Walker; Svetlana M Altamentova; Alexandra Ezersky; Graciela Lorca; Tatiana Skarina; Marina Kudritska; Linda J Ball; Alexey Bochkarev; Alexei Savchenko
Structural and biochemical study of effector molecule recognition by the E.coli glyoxylate and allantoin utilization regulatory protein AllR.
Journal of molecular biology 2006;358(3):810-28.
2006: Rongguang Zhang; Tatiana Skarina; Elena Evdokimova; Aled Edwards; Alexei Savchenko; Roman Laskowski; Marianne E Cuff; Andrzej Joachimiak
Structure of SAICAR synthase from Thermotoga maritima at 2.2 angstroms reveals an unusual covalent dimer.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 4):335-9.
2006: Jiang Yin; Linda X Xu; Maia M Cherney; Evelyne Raux-Deery; Amanda A Bindley; Alexei Savchenko; John R Walker; Marianne E Cuff; Martin J Warren; Michael N G James
Crystal structure of the vitamin B12 biosynthetic cobaltochelatase, CbiXS, from Archaeoglobus fulgidus.
Journal of structural and functional genomics 2006;7(1):37-50.
2005: Warren Sun; Xiaohui Xu; Marina Pavlova; Aled M Edwards; Andrzej Joachimiak; Alexei Savchenko; Dinesh Christendat
The crystal structure of a novel SAM-dependent methyltransferase PH1915 from Pyrococcus horikoshii.
Protein science : a publication of the Protein Society 2005;14(12):3121-8.
2005: Adelinda A Yee; Alexei Savchenko; Alexandr Ignachenko; Jonathan A Lukin; Xiaohui Xu; Tatiana Skarina; Elena Evdokimova; Cheng Song Liu; Anthony Semesi; Valerie Guido; Aled M Edwards; Cheryl H Arrowsmith
NMR and X-ray crystallography, complementary tools in structural proteomics of small proteins.
Journal of the American Chemical Society 2005;127(47):16512-7.
2005: David A R Sanders; John R Walker; Tatiana Skarina; Alexei Savchenko
The X-ray crystal structure of PA3566 from Pseudomonas aureginosa at 1.8 A resolution.
Proteins 2005;61(1):209-12.
2005: Alexei Savchenko; Nevan J Krogan; John R Cort; Elena Evdokimova; Jocelyne M Lew; Adelinda A Yee; Luis Sánchez-Pulido; Miguel Andrade; Alexey Bochkarev; John D Watson; Michael A Kennedy; Jack Greenblatt; Timothy Hughes; Cheryl H Arrowsmith; Johanna M Rommens; Aled M Edwards
The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism.
The Journal of biological chemistry 2005;280(19):19213-20.
2005: Ekaterina Kuznetsova; Michael Proudfoot; Stephen A Sanders; Jeffrey Reinking; Alexei Savchenko; Cheryl H Arrowsmith; Aled M Edwards; Alexander F Yakunin
Enzyme genomics: Application of general enzymatic screens to discover new enzymes.
FEMS microbiology reviews 2005;29(2):263-79.
2005: Marianne E Cuff; D J Miller; Sergey Korolev; X Xu; W F Anderson; Aled Edwards; Andrzej Joachimiak; Alexei Savchenko
Crystal structure of a predicted precorrin-8x methylmutase from Thermoplasma acidophilum.
Proteins 2005;58(3):751-4.
2005: Elena Dobrovetsky; Ming Liang Lu; Ronit Andorn-Broza; Galina Khutoreskaya; James E Bray; Alexei Savchenko; Cheryl H Arrowsmith; Aled M Edwards; Christopher M Koth
High-throughput production of prokaryotic membrane proteins.
Journal of structural and functional genomics 2005;6(1):33-50.
2004: Michael Proudfoot; Ekaterina Kuznetsova; Greg Brown; Narayana N Rao; Masanari Kitagawa; Hirotada Mori; Alexei Savchenko; Alexander F Yakunin
General enzymatic screens identify three new nucleotidases in Escherichia coli. Biochemical characterization of SurE, YfbR, and YjjG.
The Journal of biological chemistry 2004;279(52):54687-94.
2004: Ruslan Sanishvili; Steven Beasley; Tatiana Skarina; David Glesne; Andrzej Joachimiak; Aled Edwards; Alexei Savchenko
The crystal structure of Escherichia coli MoaB suggests a probable role in molybdenum cofactor synthesis.
The Journal of biological chemistry 2004;279(40):42139-46.
2004: James E Bray; Russell L Marsden; Stuart C G Rison; Alexei Savchenko; Aled M Edwards; Janet M Thornton; Christine A Orengo
A practical and robust sequence search strategy for structural genomics target selection.
Bioinformatics (Oxford, England) 2004;20(14):2288-95.
2004: Alexander F Yakunin; Michael Proudfoot; Ekaterina Kuznetsova; Alexei Savchenko; Greg Brown; Cheryl H Arrowsmith; Aled M Edwards
The HD domain of the Escherichia coli tRNA nucleotidyltransferase has 2',3'-cyclic phosphodiesterase, 2'-nucleotidase, and phosphatase activities.
The Journal of biological chemistry 2004;279(35):36819-27.
2004: Alexander F Yakunin; Adelinda A Yee; Alexei Savchenko; Aled M Edwards; Cheryl H Arrowsmith
Structural proteomics: a tool for genome annotation.
Current opinion in chemical biology 2004;8(1):42-8.
2004: Alexei Savchenko; Tatiana Skarina; Elena Evdokimova; John D Watson; Roman Laskowski; Cheryl H Arrowsmith; Aled M Edwards; Andrzej Joachimiak; Rong-Guang Zhang
X-ray crystal structure of CutA from Thermotoga maritima at 1.4 A resolution.
Proteins 2004;54(1):162-5.
2003: Rong-Guang Zhang; C Evalena Andersson; Tatiana Skarina; Elena Evdokimova; Aled M Edwards; Andrzej Joachimiak; Alexei Savchenko; Sherry L Mowbray
The 2.2 A resolution structure of RpiB/AlsB from Escherichia coli illustrates a new approach to the ribose-5-phosphate isomerase reaction.
Journal of molecular biology 2003;332(5):1083-94.
2003: Xiao Tao; Reza Khayat; Dinesh Christendat; Alexei Savchenko; Xiaohui Xu; Sharon Goldsmith-Fischman; Barry Honig; Aled Edwards; Cheryl H Arrowsmith; Liang Tong
Crystal structures of MTH1187 and its yeast ortholog YBL001c.
Proteins 2003;52(3):478-80.
2003: Ruslan Sanishvili; Alexander F Yakunin; Roman Laskowski; Tatiana Skarina; Elena Evdokimova; Amanda Doherty-Kirby; Gilles Lajoie; Janet M Thornton; Cheryl H Arrowsmith; Alexei Savchenko; Andrzej Joachimiak; Aled M Edwards
Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli.
The Journal of biological chemistry 2003;278(28):26039-45.
2003: Darcie J Miller; Nancy Ouellette; Elena Evdokimova; Alexei Savchenko; Aled Edwards; Wayne F Anderson
Crystal complexes of a predicted S-adenosylmethionine-dependent methyltransferase reveal a typical AdoMet binding domain and a substrate recognition domain.
Protein science : a publication of the Protein Society 2003;12(7):1432-42.
2003: Matthew S Kimber; françois vallee; Simon Houston; Alexander Necakov; Tatiana Skarina; Elena Evdokimova; Steven Beasley; Dinesh Christendat; Alexei Savchenko; Cheryl H Arrowsmith; Masoud Vedadi; Mark Gerstein; Aled M Edwards
Data mining crystallization databases: knowledge-based approaches to optimize protein crystal screens.
Proteins 2003;51(4):562-8.
2003: Claire Vieille; Harini Krishnamurthy; Hyung-Hwan Hyun; Alexei Savchenko; Honggao Yan; J Gregory Zeikus
Thermotoga neapolitana adenylate kinase is highly active at 30 degrees C.
The Biochemical journal 2003;372(Pt 2):577-85.
2003: Rong-Guang Zhang; Norma Duke; Roman Laskowski; Elena Evdokimova; Tatiana Skarina; Aled Edwards; Andrzej Joachimiak; Alexei Savchenko
Conserved protein YecM from Escherichia coli shows structural homology to metal-binding isomerases and oxygenases.
Proteins 2003;51(2):311-4.
2003: Zhiru Yang; Alexei Savchenko; Alexander F Yakunin; Rongguang Zhang; Aled Edwards; Cheryl H Arrowsmith; Liang Tong
Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643.
The Journal of biological chemistry 2003;278(10):8804-8.
2003: Adelinda Yee; Keith Pardee; Dinesh Christendat; Alexei Savchenko; Aled M Edwards; Cheryl H Arrowsmith
Structural proteomics: toward high-throughput structural biology as a tool in functional genomics.
Accounts of chemical research 2003;36(3):183-9.
2003: Alexei Savchenko; Adelinda Yee; Anna Khachatryan; Tatiana Skarina; Elena Evdokimova; Marina Pavlova; Anthony Semesi; Julian Northey; Steven Beasley; Ning Lan; Rajdeep Das; Mark Gerstein; Cheryl H Arrowmith; Aled M Edwards
Strategies for structural proteomics of prokaryotes: Quantifying the advantages of studying orthologous proteins and of using both NMR and X-ray crystallography approaches.
Proteins 2003;50(3):392-9.
2003: Rong guang Zhang; C Evalena Andersson; Alexei Savchenko; Tatiana Skarina; Elena Evdokimova; Steven Beasley; Cheryl H Arrowsmith; Aled M Edwards; Andrzej Joachimiak; Sherry L Mowbray
Structure of Escherichia coli ribose-5-phosphate isomerase: a ubiquitous enzyme of the pentose phosphate pathway and the Calvin cycle.
Structure (London, England : 1993) 2003;11(1):31-42.
2002: Sergey Korolev; Tatiana Skarina; Elena Evdokimova; Steven Beasley; Aled Edwards; Andrzej Joachimiak; Alexei Savchenko
Crystal structure of glutamine amidotransferase from Thermotoga maritima.
Proteins 2002;49(3):420-2.
2002: Youngchang Kim; Tatiana Skarina; Steven Beasley; Roman Laskowski; Cheryl H Arrowsmith; Andrzej Joachimiak; Aled Edwards; Alexei Savchenko
Crystal structure of Escherichia coli EC1530, a glyoxylate induced protein YgbM.
Proteins 2002;48(2):427-30.
2002: Rong-Guang Zhang; Youngchang Kim; Tatiana Skarina; Steven Beasley; Roman Laskowski; Cheryl H Arrowsmith; Aled Edwards; Andrzej Joachimiak; Alexei Savchenko
Crystal structure of Thermotoga maritima 0065, a member of the IclR transcriptional factor family.
The Journal of biological chemistry 2002;277(21):19183-90.
2002: Alexei Savchenko; Claire Vieille; Suil Kang; J Gregory Zeikus
Pyrococcus furiosus alpha-amylase is stabilized by calcium and zinc.
Biochemistry 2002;41(19):6193-201.
2002: Sergey Korolev; Yoshihiko Ikeguchi; Tatiana Skarina; Steven Beasley; Cheryl H Arrowsmith; Aled Edwards; Andrzej Joachimiak; Anthony E Pegg; Alexei Savchenko
The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor.
Nature structural biology 2002;9(1):27-31.
2001: Rong-Guang Zhang; Tatiana Skarina; J E Katz; Steven Beasley; A Khachatryan; S Vyas; Cheryl H Arrowsmith; S Clarke; Aled Edwards; Andrzej Joachimiak; Alexei Savchenko
Structure of Thermotoga maritima stationary phase survival protein SurE: a novel acid phosphatase.
Structure (London, England : 1993) 2001;9(11):1095-106.
2001: Alexei Savchenko; W Wang; Claire Vieille; J Gregory Zeikus
Alkaline phosphatase from Thermotoga neapolitana.
Methods in enzymology 2001;331():298-305.
2001: Alexei Savchenko; Claire Vieille; J Gregory Zeikus
alpha-Amylases and amylopullulanase from Pyrococcus furiosus.
Methods in enzymology 2001;330():354-63.
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Structural proteomics of an archaeon.
Nature structural biology 2000;7(10):903-9.
1998: J Gregory Zeikus; Claire Vieille; Alexei Savchenko
Thermozymes: biotechnology and structure-function relationships.
Extremophiles : life under extreme conditions 1998;2(3):179-83.
1997: G Dong; Claire Vieille; Alexei Savchenko; J Gregory Zeikus
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