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Alexandru Saveanu

Research Profile

Chemicals & Drugs

Disorders

Anatomy

Tumor Cells, Cultured

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Publications

TOP 3
Faïza Lamine; Emna Menif; Alexandru Saveanu; Anne Barlier; Thierry Brue; Melika Chihaoui; Alain Enjalbert; Faouzi Kanoun; Hédia Slimane
Unilateral agenesis of internal carotid artery associated with congenital combined pituitary hormone deficiency and pituitary stalk interruption without HESX1, LHX4 or OTX2 mutation: a case report.
Rachel Reynaud; Philippe Rondard; Alexandru Saveanu; Gilbert Simonin; Anne-Marie Guedj; Anne Guiochon-Mantel; Sujatha A Jayakody; Pierre Lecomte; Juan Pedro Martinez-Barbera; Carine Monnier; Anne Barlier; Jérôme BOULIGAND; Thierry Brue
PROKR2 variants in multiple hypopituitarism with pituitary stalk interruption.
Thomas Cuny; Céline Defilles; Alain Enjalbert; Dominique Figarella-Branger; Anne-Laure Germanetti; Thomas Graillon; Amira Mohamed; Catherine Roche; Anne Barlier; Bettina Couderc; Alexandru Saveanu
Somatostatin receptor sst2 gene transfer in human prolactinomas in vitro: impact on sensitivity to dopamine, somatostatin and dopastatin, in the control of prolactin secretion.

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All Publications

2012: Faïza Lamine; Emna Menif; Alexandru Saveanu; Anne Barlier; Thierry Brue; Melika Chihaoui; Alain Enjalbert; Faouzi Kanoun; Hédia Slimane
Unilateral agenesis of internal carotid artery associated with congenital combined pituitary hormone deficiency and pituitary stalk interruption without HESX1, LHX4 or OTX2 mutation: a case report.
Pituitary 2012;15 Suppl 1():S81-6.
2012: Rachel Reynaud; Philippe Rondard; Alexandru Saveanu; Gilbert Simonin; Anne-Marie Guedj; Anne Guiochon-Mantel; Sujatha A Jayakody; Pierre Lecomte; Juan Pedro Martinez-Barbera; Carine Monnier; Anne Barlier; Jérôme BOULIGAND; Thierry Brue
PROKR2 variants in multiple hypopituitarism with pituitary stalk interruption.
The Journal of clinical endocrinology and metabolism 2012;97(6):E1068-73.
2012: Thomas Cuny; Céline Defilles; Alain Enjalbert; Dominique Figarella-Branger; Anne-Laure Germanetti; Thomas Graillon; Amira Mohamed; Catherine Roche; Anne Barlier; Bettina Couderc; Alexandru Saveanu
Somatostatin receptor sst2 gene transfer in human prolactinomas in vitro: impact on sensitivity to dopamine, somatostatin and dopastatin, in the control of prolactin secretion.
Molecular and cellular endocrinology 2012;355(1):106-13.
2012: Frederic Castinetti; Rachel Reynaud; Alexandru Saveanu; Anne Barlier; Thierry Brue
Genetic causes of combined pituitary hormone deficiencies in humans.
Annales d'endocrinologie 2012;73(2):53-5.
2012: C Couture; J Drouin; A Enjalbert; M Fassnacht; C E Flück; M Houang; M Maes; F Phan-Hug; Alexandru Saveanu; Anne Barlier; T Brue; J C Carel; S Vallette
Phenotypic homogeneity and genotypic variability in a large series of congenital isolated ACTH-deficiency patients with TPIT gene mutations.
The Journal of clinical endocrinology and metabolism 2012;97(3):E486-95.
2012: Federico Gatto; Massimo Giusti; Leo J Hofland; Francesco Minuto; Jean Louis Ravetti; Alexandru Saveanu; Stefan Schulz; Roberto Wurth; Gianluigi Zona; Federica Barbieri; Michael D Culler; Diego Ferone; Monica Gatti; Tullio Florio
Balance between somatostatin and D2 receptor expression drives TSH-secreting adenoma response to somatostatin analogues and dopastatins.
Clinical endocrinology 2012;76(3):407-14.
2011: Sandra Pekic; Rachel Reynaud; Alexandru Saveanu; Anne Barlier; Thierry Brue; Mirjana Doknic; Dragana Miljic; Vera Popovic
Case seminar: a young female with acute hyponatremia and a sellar mass.
Endocrine 2011;40(3):325-31.
2011: Rachel Reynaud; Alexandru Saveanu; F Albarel-Loy; Anne Barlier; Frederic Castinetti; Alain Enjalbert; N Galon-Faure; N Jullien; A Khammar; Marie-Helene Quentien; Thierry Brue
[Genetic aspects of growth hormone deficiency].
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie 2011;18(6):696-706.
2011: Alexandru Saveanu; Mihaela Muresan; Catherine De Micco; David Taieb; Anne-Laure Germanetti; Frederic Sebag; Jean-François Henry; Laurent Brunaud; Alain Enjalbert; Georges Weryha; Anne Barlier
Expression of somatostatin receptors, dopamine D₂ receptors, noradrenaline transporters, and vesicular monoamine transporters in 52 pheochromocytomas and paragangliomas.
Endocrine-related cancer 2011;18(2):287-300.
2009: Frederic Castinetti; Alexandru Saveanu; Isabelle Morange; Thierry Brue
Lanreotide for the treatment of acromegaly.
Advances in therapy 2009;26(6):600-12.
2009: Alexandru Saveanu; Philippe Jaquet
Somatostatin-dopamine ligands in the treatment of pituitary adenomas.
Reviews in endocrine & metabolic disorders 2009;10(2):83-90.
2009: Julie Acunzo; Alexandru Saveanu; Corinne Gérard; Alain Enjalbert; Anne Barlier
[Mechanisms of pituitary tumorigenesis].
Presse médicale (Paris, France : 1983) 2009;38(1):76-83.
2008: Tullio Florio; Federica Barbieri; Renato Spaziante; Gianluigi Zona; Leo J Hofland; Peter M Van Koetsveld; Richard A Feelders; Günter K Stalla; Marily Theodoropoulou; Michael D Culler; Jesse Dong; John E Taylor; Jacques-Pierre Moreau; Alexandru Saveanu; Ginette Gunz; Henry Dufour; Philippe Jaquet
Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study.
Endocrine-related cancer 2008;15(2):583-96.
2008: Alexandru Saveanu; Philippe Jaquet; Thierry Brue; Anne Barlier
Relevance of coexpression of somatostatin and dopamine D2 receptors in pituitary adenomas.
Molecular and cellular endocrinology 2008;286(1-2):206-13.
2008: Alessandra Fusco; Ginette Gunz; Philippe Jaquet; Henry Dufour; Anne Laure Germanetti; Michael D Culler; Anne Barlier; Alexandru Saveanu
Somatostatinergic ligands in dopamine-sensitive and -resistant prolactinomas.
European journal of endocrinology / European Federation of Endocrine Societies 2008;158(5):595-603.
2007: Eugenia Resmini; Patrizia Dadati; Jean Louis Ravetti; Gianluigi Zona; Renato Spaziante; Alexandru Saveanu; Philippe Jaquet; Michael D Culler; Federico Bianchi; Alberto Rebora; Francesco Minuto; Diego Ferone
Rapid pituitary tumor shrinkage with dissociation between antiproliferative and antisecretory effects of a long-acting octreotide in an acromegalic patient.
The Journal of clinical endocrinology and metabolism 2007;92(5):1592-9.
2007: Diego Ferone; Alexandru Saveanu; Michael D Culler; Marica Arvigo; Alberto Rebora; Federico Gatto; Francesco Minuto; Philippe Jaquet
Novel chimeric somatostatin analogs: facts and perspectives.
European journal of endocrinology / European Federation of Endocrine Societies 2007;156 Suppl 1():S23-8.
2006: Dermot O'Toole; Alexandru Saveanu; Anne Couvelard; Ginette Gunz; Alain Enjalbert; Philippe Jaquet; Philippe Ruszniewski; Anne Barlier
The analysis of quantitative expression of somatostatin and dopamine receptors in gastro-entero-pancreatic tumours opens new therapeutic strategies.
European journal of endocrinology / European Federation of Endocrine Societies 2006;155(6):849-57.
2006: Ichiro Miyata; Sophie Vallette-Kasic; Alexandru Saveanu; Mizuho Takeuchi; Hideki Yoshikawa; Asako Tajima; Katsuyoshi Tojo; Rachel Reynaud; Magali Gueydan; Alain Enjalbert; Naoko Tajima; Yoshikatsu Eto; Thierry Brue
Identification and functional analysis of the novel S179R POU1F1 mutation associated with combined pituitary hormone deficiency.
The Journal of clinical endocrinology and metabolism 2006;91(12):4981-7.
2006: Rachel Reynaud; Magali Gueydan; Alexandru Saveanu; Sophie Vallette-Kasic; Alain Enjalbert; Thierry Brue; Anne Barlier
Genetic screening of combined pituitary hormone deficiency: experience in 195 patients.
The Journal of clinical endocrinology and metabolism 2006;91(9):3329-36.
2006: Alexandru Saveanu; Ginette Gunz; Severine Guillen; Henry Dufour; Michael D Culler; Philippe Jaquet
Somatostatin and dopamine-somatostatin multiple ligands directed towards somatostatin and dopamine receptors in pituitary adenomas.
Neuroendocrinology 2006;83(3-4):258-63.
2005: Diego Ferone; Marica Arvigo; Claudia Semino; Philippe Jaquet; Alexandru Saveanu; John E Taylor; Jacques-Pierre Moreau; Michael D Culler; Manuela Albertelli; Francesco Minuto; Antonina Barreca
Somatostatin and dopamine receptor expression in lung carcinoma cells and effects of chimeric somatostatin-dopamine molecules on cell proliferation.
American journal of physiology. Endocrinology and metabolism 2005;289(6):E1044-50.
2005: Rachel Reynaud; Anne Barlier; Sophie Vallette-Kasic; Alexandru Saveanu; Marie-Pierre Guillet; Gilbert Simonin; Alain Enjalbert; Paul Valensi; Thierry Brue
An uncommon phenotype with familial central hypogonadism caused by a novel PROP1 gene mutant truncated in the transactivation domain.
The Journal of clinical endocrinology and metabolism 2005;90(8):4880-7.
2005: James P G Turton; Rachel Reynaud; Ameeta Mehta; John Torpiano; Alexandru Saveanu; Kathryn S Woods; Anatoly Tiulpakov; Vera Zdravkovic; Jill Hamilton; Simon Attard-Montalto; Ray Parascandalo; Cecil Vella; Peter E Clayton; Stephen M Shalet; John Barton; Thierry Brue; Mehul T Dattani
Novel mutations within the POU1F1 gene associated with variable combined pituitary hormone deficiency.
The Journal of clinical endocrinology and metabolism 2005;90(8):4762-70.
2005: Philippe Jaquet; Ginette Gunz; Alexandru Saveanu; Henry Dufour; John Taylor; Josse Dong; Sun Kim; Jacques-Pierre Moreau; Alain Enjalbert; Michael D Culler
Efficacy of chimeric molecules directed towards multiple somatostatin and dopamine receptors on inhibition of GH and prolactin secretion from GH-secreting pituitary adenomas classified as partially responsive to somatostatin analog therapy.
European journal of endocrinology / European Federation of Endocrine Societies 2005;153(1):135-41.
2005: Rachel Reynaud; Anne Barlier; Alexandru Saveanu; Marie-Helene Quentien; Alain Enjalbert; Thierry Brue
[Genetics of anterior hypopituitary diseases].
Annales d'endocrinologie 2005;66(3):250-7.
2005: Philippe Jaquet; Ginette Gunz; Alexandru Saveanu; Anne Barlier; Henry Dufour; John Taylor; Josse Dong; Sun Kim; Jacques-Pierre Moreau; Michael D Culler
BIM-23A760, a chimeric molecule directed towards somatostatin and dopamine receptors, vs universal somatostatin receptors ligands in GH-secreting pituitary adenomas partial responders to octreotide.
Journal of endocrinological investigation 2005;28(11 Suppl International):21-7.
2005: Philippe Jaquet; Alexandru Saveanu; Anne Barlier
New SRIF analogs in the control of human pituitary adenomas: perspectives.
Journal of endocrinological investigation 2005;28(5 Suppl):14-8.
2004: Slavica Krantic; Isabelle Goddard; Alexandru Saveanu; N Giannetti; Joanna Fombonne; A Cardoso; Philippe Jaquet; Alain Enjalbert
Novel modalities of somatostatin actions.
European journal of endocrinology / European Federation of Endocrine Societies 2004;151(6):643-55.
2004: Rachel Reynaud; Alexandru Saveanu; Anne Barlier; Alain Enjalbert; Thierry Brue
Pituitary hormone deficiencies due to transcription factor gene alterations.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2004;14(6):442-8.
2004: Rachel Reynaud; Anne Barlier; Molka Chadli-Chaieb; Alexandru Saveanu; Gilbert Simonin; Alain Enjalbert; Thierry Brue
[Congenital hypopituitarism: when should transcription factor gene screenings be performed?].
Presse médicale (Paris, France : 1983) 2004;33(6):400-5.
2003: Alexandru Saveanu; Ginette Gunz; Henry Dufour; Alain Enjalbert; Michael D Culler; Philippe Jaquet
Distribution and functionality of the somatostatin receptor subtypes in acromegaly.
Journal of endocrinological investigation 2003;26(8 Suppl):4-7.
2002: Alexandru Saveanu; Esteban Lavaque; Ginette Gunz; Anne Barlier; Sun Kim; John E Taylor; Michael D Culler; Alain Enjalbert; Philippe Jaquet
Demonstration of enhanced potency of a chimeric somatostatin-dopamine molecule, BIM-23A387, in suppressing growth hormone and prolactin secretion from human pituitary somatotroph adenoma cells.
The Journal of clinical endocrinology and metabolism 2002;87(12):5545-52.
2001: Alexandru Saveanu; Isabelle Morange-Ramos; Ginette Gunz; Henry Dufour; Alain Enjalbert; Philippe Jaquet
A luteinizing hormone-, alpha-subunit- and prolactin-secreting pituitary adenoma responsive to somatostatin analogs: in vivo and in vitro studies.
European journal of endocrinology / European Federation of Endocrine Societies 2001;145(1):35-41.
2001: Alexandru Saveanu; Ginette Gunz; Henry Dufour; P Caron; Frederic Fina; L'Houcine Ouafik; Michael D Culler; Jacques-Pierre Moreau; Alain Enjalbert; Philippe Jaquet
Bim-23244, a somatostatin receptor subtype 2- and 5-selective analog with enhanced efficacy in suppressing growth hormone (GH) from octreotide-resistant human GH-secreting adenomas.
The Journal of clinical endocrinology and metabolism 2001;86(1):140-5.
2000: Philippe Jaquet; Alexandru Saveanu; Ginette Gunz; Frederic Fina; Alfredo J Zamora; Michel Grino; Michael D Culler; Jacques-Pierre Moreau; Alain Enjalbert; L'Houcine Ouafik
Human somatostatin receptor subtypes in acromegaly: distinct patterns of messenger ribonucleic acid expression and hormone suppression identify different tumoral phenotypes.
The Journal of clinical endocrinology and metabolism 2000;85(2):781-92.
1999: Alexandru Saveanu; Anne Barlier; C De Boissezon; G Kertesz; F Jean; B Argémi; H Cailla; Philippe Jaquet
[Evaluation of an immunoradiometric assay for succinylated ACTH].
Annales d'endocrinologie 1999;60(5):414-21.
1999: Philippe Jaquet; L'Houcine Ouafik; Alexandru Saveanu; Ginette Gunz; Frederic Fina; Henry Dufour; Michael D Culler; Jacques-Pierre Moreau; Alain Enjalbert
Quantitative and functional expression of somatostatin receptor subtypes in human prolactinomas.
The Journal of clinical endocrinology and metabolism 1999;84(9):3268-76.