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Alexei Savinov

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Sergey A Shiryaev; Albert G Remacle; Alexei Y Savinov; Andrei V Chernov; Piotr Cieplak; Ilian A Radichev; Roy Williams; Tatiana N Shiryaeva; Katarzyna Gawlik; Tatiana I Postnova; Boris I Ratnikov; Alexey Eroshkin; Khatereh Motamedchaboki; Jeffrey W Smith; Alex Y Strongin
Inflammatory proprotein convertase-matrix metalloproteinase proteolytic pathway in antigen-presenting cells as a step to autoimmune multiple sclerosis.
Dmitri V Rozanov; Alexei Y Savinov; Vladislav Golubkov; Olga L Rozanova; Tatiana I Postnova; Eduard A Sergienko; Stefan Vasile; Alexander E Aleshin; Michele F Rega; Surya De; Alex Y Strongin
Engineering a leucine zipper-TRAIL homotrimer with improved cytotoxicity in tumor cells.
Seung-Hee Lee; Ergeng Hao; Alexei Y Savinov; Ifat Geron; Alex Y Strongin; Pamela Itkin-Ansari
Human beta-cell precursors mature into functional insulin-producing cells in an immunoisolation device: implications for diabetes cell therapies.

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All Publications

2009: Sergey A Shiryaev; Albert G Remacle; Alexei Y Savinov; Andrei V Chernov; Piotr Cieplak; Ilian A Radichev; Roy Williams; Tatiana N Shiryaeva; Katarzyna Gawlik; Tatiana I Postnova; Boris I Ratnikov; Alexey Eroshkin; Khatereh Motamedchaboki; Jeffrey W Smith; Alex Y Strongin
Inflammatory proprotein convertase-matrix metalloproteinase proteolytic pathway in antigen-presenting cells as a step to autoimmune multiple sclerosis.
The Journal of biological chemistry 2009;284(44):30615-26.
2009: Dmitri V Rozanov; Alexei Y Savinov; Vladislav Golubkov; Olga L Rozanova; Tatiana I Postnova; Eduard A Sergienko; Stefan Vasile; Alexander E Aleshin; Michele F Rega; Surya De; Alex Y Strongin
Engineering a leucine zipper-TRAIL homotrimer with improved cytotoxicity in tumor cells.
Molecular cancer therapeutics 2009;8(6):1515-25.
2009: Seung-Hee Lee; Ergeng Hao; Alexei Y Savinov; Ifat Geron; Alex Y Strongin; Pamela Itkin-Ansari
Human beta-cell precursors mature into functional insulin-producing cells in an immunoisolation device: implications for diabetes cell therapies.
Transplantation 2009;87(7):983-91.
2009: Sergey A Shiryaev; Alexei Y Savinov; Piotr Cieplak; Boris I Ratnikov; Khatereh Motamedchaboki; Jeffrey W Smith; Alex Y Strongin
Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis.
PloS one 2009;4(3):e4952.
2008: Dmitri V Rozanov; Alexei Y Savinov; Roy Williams; Kang Liu; Vladislav Golubkov; Stan Krajewski; Alex Y Strongin
Molecular signature of MT1-MMP: transactivation of the downstream universal gene network in cancer.
Cancer research 2008;68(11):4086-96.
2008: Shjerida Johnson; Li-Hsing Chen; Rebecca Harbach; Mojgan Sabet; Alexei Y Savinov; Naomi J H Cotton; Alex Y Strongin; Donald G Guiney; Maurizio Pellecchia
Rhodanine derivatives as selective protease inhibitors against bacterial toxins.
Chemical biology & drug design 2008;71(2):131-9.
2007: Alexei Y Savinov; Dmitri V Rozanov; Alex Y Strongin
Specific inhibition of autoimmune T cell transmigration contributes to beta cell functionality and insulin synthesis in non-obese diabetic (NOD) mice.
The Journal of biological chemistry 2007;282(44):32106-11.
2007: Sergey A Shiryaev; Albert G Remacle; Boris I Ratnikov; Nicholas A Nelson; Alexei Y Savinov; Ge Wei; Massimo Bottini; Michele F Rega; Amelie Parent; Roxane Desjardins; Martin Fugere; Robert Day; Mojgan Sabet; Maurizio Pellecchia; Robert C Liddington; Jeffrey W Smith; Tomas Mustelin; Donald G Guiney; Michal Lebl; Alex Y Strongin
Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens.
The Journal of biological chemistry 2007;282(29):20847-53.
2007: Alexei Y Savinov; Alex Y Strongin
Defining the roles of T cell membrane proteinase and CD44 in type 1 diabetes.
IUBMB life 2007;59(1):6-13.
2006: Vladislav Golubkov; Alexei V Chekanov; Alexei Y Savinov; Dmitri V Rozanov; Natalya V Golubkova; Alex Y Strongin
Membrane type-1 matrix metalloproteinase confers aneuploidy and tumorigenicity on mammary epithelial cells.
Cancer research 2006;66(21):10460-5.
2006: Alexei Y Savinov; Dmitri V Rozanov; Alex Y Strongin
Mechanistic insights into targeting T cell membrane proteinase to promote islet beta-cell rejuvenation in type 1 diabetes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(11):1793-801.
2006: Albert G Remacle; Alexei V Chekanov; Vladislav Golubkov; Alexei Y Savinov; Dmitri V Rozanov; Alex Y Strongin
O-glycosylation regulates autolysis of cellular membrane type-1 matrix metalloproteinase (MT1-MMP).
The Journal of biological chemistry 2006;281(25):16897-905.
2006: Dmitri V Rozanov; Alexei Y Savinov; Vladislav Golubkov; Stephen Tomlinson; Alex Y Strongin
Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice.
Cancer research 2006;66(12):6258-63.
2006: Alexei Y Savinov; Albert G Remacle; Vladislav Golubkov; Maryla Krajewska; Susan Kennedy; Michael J Duffy; Dmitri V Rozanov; Stan Krajewski; Alex Y Strongin
Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients.
Cancer research 2006;66(5):2716-24.
2006: Alexei V Chekanov; Albert G Remacle; Vladislav Golubkov; Vladimir S Akatov; Sergey Sikora; Alexei Y Savinov; Martin Fugere; Robert Day; Dmitri V Rozanov; Alex Y Strongin
Both PA63 and PA83 are endocytosed within an anthrax protective antigen mixed heptamer: a putative mechanism to overcome a furin deficiency.
Archives of biochemistry and biophysics 2006;446(1):52-9.
2005: Alexei Y Savinov; Dmitri V Rozanov; Vladislav Golubkov; F Susan Wong; Alex Y Strongin
Inhibition of membrane type-1 matrix metalloproteinase by cancer drugs interferes with the homing of diabetogenic T cells into the pancreas.
The Journal of biological chemistry 2005;280(30):27755-8.
2005: Martino Forino; Sherida Johnson; Thiang Y Wong; Dmitri V Rozanov; Alexei Y Savinov; Wei Li; Roberto Fattorusso; Barbara Becattini; Andrew J W Orry; Dawoon Jung; Ruben Abagyan; Jeffrey W Smith; Ken Alibek; Robert C Liddington; Alex Y Strongin; Surya De
Efficient synthetic inhibitors of anthrax lethal factor.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(27):9499-504.
2005: Vladislav Golubkov; Sarah Boyd; Alexei Y Savinov; Alexei V Chekanov; Andrei Osterman; Albert G Remacle; Dmitri V Rozanov; Stephen J Doxsey; Alex Y Strongin
Membrane type-1 matrix metalloproteinase (MT1-MMP) exhibits an important intracellular cleavage function and causes chromosome instability.
The Journal of biological chemistry 2005;280(26):25079-86.
2004: Wei Li; Alexei Y Savinov; Dmitri V Rozanov; Vladislav Golubkov; Hirad Hedayat; Tatiana I Postnova; Natalia V Golubkova; Yu Linli; Stan Krajewski; Alex Y Strongin
Matrix metalloproteinase-26 is associated with estrogen-dependent malignancies and targets alpha1-antitrypsin serpin.
Cancer research 2004;64(23):8657-65.
2004: Dmitri V Rozanov; Sergey Sikora; Adam Godzik; Tatiana I Postnova; Vladislav Golubkov; Alexei Y Savinov; Stephen Tomlinson; Alex Y Strongin
Non-proteolytic, receptor/ligand interactions associate cellular membrane type-1 matrix metalloproteinase with the complement component C1q.
The Journal of biological chemistry 2004;279(48):50321-8.
2004: Dmitri V Rozanov; Alexei Y Savinov; Vladislav Golubkov; Tatiana I Postnova; Albert G Remacle; Stephen Tomlinson; Alex Y Strongin
Cellular membrane type-1 matrix metalloproteinase (MT1-MMP) cleaves C3b, an essential component of the complement system.
The Journal of biological chemistry 2004;279(45):46551-7.
2003: Alexei Y Savinov; F Susan Wong; Austin C Stonebraker; Alexander V Chervonsky
Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells.
The Journal of experimental medicine 2003;197(5):643-56.
2003: Alexei Y Savinov; Andrew Tcherepanov; E Allison Green; Richard A Flavell; Alexander V Chervonsky
Contribution of Fas to diabetes development.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(2):628-32.
2001: Alexei Y Savinov; F Susan Wong; Alexander V Chervonsky
IFN-gamma affects homing of diabetogenic T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(11):6637-43.
2001: Clayton E Mathews; Robert T Graser; Alexei Y Savinov; David V Serreze; Edward H Leiter
Unusual resistance of ALR/Lt mouse beta cells to autoimmune destruction: role for beta cell-expressed resistance determinants.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(1):235-40.
2000: Y Liu; D L McMinimy; Alexei Y Savinov; K A Johnson; SG Kremlev; Andrei I Chapoval; Igor K Egorov
Hidden variables: unstable Abeta chain genes encoding antigen recognition structures in tumor survivors.
Molecular immunology 2000;37(18):1091-110.
2000: Y Liu; Alexei Y Savinov; D L McMinimy; SG Kremlev; Andrei I Chapoval; Igor K Egorov
The A beta 6w302 gene and molecular mechanisms of resistance to the spread of radiation-induced lymphoma in a mouse mutant, survivor-27.
Radiatsionnaia biologiia, radioecologiia / Rossiĭskaia akademiia nauk 2000;40(5):500-5.