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Jouko Savolainen

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Timo Korjamo; Jukka Holappa; Sanna Taimisto; Jouko Savolainen; Tomi Järvinen; Jukka Mönkkönen
Effect of N-betainate and N-piperazine derivatives of chitosan on the paracellular transport of mannitol in Caco-2 cells.
Hannu Kokki; Elina Kumpulainen; Merja Laisalmi; Jouko Savolainen; Jarkko Rautio; Marko Lehtonen
Diclofenac readily penetrates the cerebrospinal fluid in children.
Elina Kumpulainen; Hannu Kokki; Merja Laisalmi; Markku Heikkinen; Jouko Savolainen; Jarkko Rautio; Marko Lehtonen
How readily does ketorolac penetrate cerebrospinal fluid in children?

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All Publications

2008: Timo Korjamo; Jukka Holappa; Sanna Taimisto; Jouko Savolainen; Tomi Järvinen; Jukka Mönkkönen
Effect of N-betainate and N-piperazine derivatives of chitosan on the paracellular transport of mannitol in Caco-2 cells.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008;35(3):226-34.
2008: Hannu Kokki; Elina Kumpulainen; Merja Laisalmi; Jouko Savolainen; Jarkko Rautio; Marko Lehtonen
Diclofenac readily penetrates the cerebrospinal fluid in children.
British journal of clinical pharmacology 2008;65(6):879-84.
2008: Elina Kumpulainen; Hannu Kokki; Merja Laisalmi; Markku Heikkinen; Jouko Savolainen; Jarkko Rautio; Marko Lehtonen
How readily does ketorolac penetrate cerebrospinal fluid in children?
Journal of clinical pharmacology 2008;48(4):495-501.
2008: Jarkko Rautio; Hanna Kumpulainen; Tycho Heimbach; Reza Oliyai; Dooman Oh; Tomi Järvinen; Jouko Savolainen
Prodrugs: design and clinical applications.
Nature reviews. Drug discovery 2008;7(3):255-70.
2008: Mikko Gynther; Krista Laine; Jarmo Ropponen; Jukka Leppänen; Anne Mannila; Tapio Nevalainen; Jouko Savolainen; Tomi Järvinen; Jarkko Rautio
Large neutral amino acid transporter enables brain drug delivery via prodrugs.
Journal of medicinal chemistry 2008;51(4):932-6.
2008: Jarkko Rautio; Krista Laine; Mikko Gynther; Jouko Savolainen
Prodrug approaches for CNS delivery.
The AAPS journal 2008;10(1):92-102.
2008: Tiina M Kääriäinen; Marko Lehtonen; Markus M Forsberg; Jouko Savolainen; Mikko Käenmäki; Pekka T Männistö
Comparison of the effects of deramciclane, ritanserin and buspirone on extracellular dopamine and its metabolites in striatum and nucleus accumbens of freely moving rats.
Basic & clinical pharmacology & toxicology 2008;102(1):50-8.
2007: Hannu Kokki; Elina Kumpulainen; Marko Lehtonen; Merja Laisalmi; Markku Heikkinen; Jouko Savolainen; Jarkko Rautio
Cerebrospinal fluid distribution of ibuprofen after intravenous administration in children.
Pediatrics 2007;120(4):e1002-8.
2007: Elina Kumpulainen; Hannu Kokki; Toivo Halonen; Markku Heikkinen; Jouko Savolainen; Merja Laisalmi
Paracetamol (acetaminophen) penetrates readily into the cerebrospinal fluid of children after intravenous administration.
Pediatrics 2007;119(4):766-71.
2007: Anne Mannila; Elina Kumpulainen; Marko Lehtonen; Markku Heikkinen; Merja Laisalmi; Terhi Salo; Jarkko Rautio; Jouko Savolainen; Hannu Kokki
Plasma and cerebrospinal fluid concentrations of indomethacin in children after intravenous administration.
Journal of clinical pharmacology 2007;47(1):94-100.
2006: Anne Mannila; Hannu Kokki; Markku Heikkinen; Merja Laisalmi; Marko Lehtonen; Hanna L Louhisto; Tomi Järvinen; Jouko Savolainen
Cerebrospinal fluid distribution of ketoprofen after intravenous administration in young children.
Clinical pharmacokinetics 2006;45(7):737-43.
2005: Markus M Forsberg; Marko Huotari; Jouko Savolainen; Pekka T Männistö
The role of physicochemical properties of entacapone and tolcapone on their efficacy during local intrastriatal administration.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2005;24(5):503-11.
2005: Jouko Savolainen; Riku Niemi; Antti Mäntylä; Juhani Huuskonen; Tomi Järvinen
Fadolmidine-induced ocular hypotension in normotensive rabbits.
The Journal of pharmacy and pharmacology 2005;57(2):191-5.
2005: Jouko Savolainen; Anne Mannila
[The blood-brain barrier is challenging drug development].
Duodecim; lääketieteellinen aikakauskirja 2005;121(1):37-43.
2005: Anne Mannila; Jarkko Rautio; Marko Lehtonen; Tomi Järvinen; Jouko Savolainen
Inefficient central nervous system delivery limits the use of ibuprofen in neurodegenerative diseases.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2005;24(1):101-5.
2003: Jouko Savolainen; Jarkko Rautio; Roberta Razzetti; Tomi Järvinen
A novel D2-dopaminergic and alpha2-adrenoceptor receptor agonist induces substantial and prolonged IOP decrease in normotensive rabbits.
The Journal of pharmacy and pharmacology 2003;55(6):789-94.
2003: Tycho Heimbach; Doo-Man Oh; Lilian Y Li; Markus M Forsberg; Jouko Savolainen; Jukka Leppänen; Yasushi Matsunaga; Gordon Flynn; David Fleisher
Absorption rate limit considerations for oral phosphate prodrugs.
Pharmaceutical research 2003;20(6):848-56.
2003: Markus M Forsberg; Marko Lehtonen; Markku Heikkinen; Jouko Savolainen; Tomi Järvinen; Pekka T Männistö
Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat.
The Journal of pharmacology and experimental therapeutics 2003;304(2):498-506.
2002: Markus M Forsberg; Jouko Savolainen; Tomi Järvinen; Jukka Leppänen; Jukka Gynther; Pekka T Männistö
Pharmacodynamic response of entacapone in rats after administration of entacapone formulations and prodrugs with varying bioavailabilities.
Pharmacology & toxicology 2002;90(6):327-32.
2001: Jukka Leppänen; Jouko Savolainen; Tapio Nevalainen; Markus M Forsberg; Juhani Huuskonen; Hannu Taipale; Jukka Gynther; Pekka T Männistö; Tomi Järvinen
Synthesis and in-vitro/in-vivo evaluation of orally administered entacapone prodrugs.
The Journal of pharmacy and pharmacology 2001;53(11):1489-98.
2000: Jukka Leppänen; Juhani Huuskonen; Jouko Savolainen; Tapio Nevalainen; Hannu Taipale; Jouko Vepsäläinen; Jukka Gynther; Tomi Järvinen
Synthesis of a water-soluble prodrug of entacapone.
Bioorganic & medicinal chemistry letters 2000;10(17):1967-9.
2000: Jouko Savolainen; J Leppanen; Markus M Forsberg; Hannu Taipale; Tapio Nevalainen; Juhani Huuskonen; Jukka Gynther; P T Mannisto; Tomi Jarvinen
Synthesis and in vitro/in vivo evaluation of novel oral N-alkyl- and N,N-dialkyl-carbamate esters of entacapone.
Life sciences 2000;67(2):205-16.
1999: Tommy Tarvainen; B Svarfvar; Satu Akerman; Jouko Savolainen; M Karhu; Timo Petteri Paronen; Kristiina Järvinen
Drug release from a porous ion-exchange membrane in vitro.
Biomaterials 1999;20(22):2177-83.
1998: Jouko Savolainen; Kristiina Järvinen; Hannu Taipale; Pekka Jarho; Thorsteinn Loftsson; Tomi Järvinen
Co-administration of a water-soluble polymer increases the usefulness of cyclodextrins in solid oral dosage forms.
Pharmaceutical research 1998;15(11):1696-701.