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John Savory

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John Savory; Othman Ghribi
Can studies of aluminum toxicity in vivo and in vitro provide relevant information on the pathogenesis and etiology of Alzheimer's disease?
John Savory; Mary M Herman; Othman Ghribi
Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer's disease.
John Savory; Mary M Herman; Othman Ghribi
Supplementation of the diet with silicic acid to reduce body burden of aluminum: a miracle cure or useless treatment for Alzheimer's disease?

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All Publications

2007: John Savory; Othman Ghribi
Can studies of aluminum toxicity in vivo and in vitro provide relevant information on the pathogenesis and etiology of Alzheimer's disease?
Journal of Alzheimer's disease : JAD 2007;11(4):429-30; discussion 431-2.
2006: John Savory; Mary M Herman; Othman Ghribi
Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2006;10(2-3):135-44.
2006: John Savory; Mary M Herman; Othman Ghribi
Supplementation of the diet with silicic acid to reduce body burden of aluminum: a miracle cure or useless treatment for Alzheimer's disease?
Journal of Alzheimer's disease : JAD 2006;10(1):25-7.
2006: David A DeWitt; Jennifer A Hurd; Nena Fox; Brigitte E Townsend; Kathleen J S Griffioen; Othman Ghribi; John Savory
Peri-nuclear clustering of mitochondria is triggered during aluminum maltolate induced apoptosis.
Journal of Alzheimer's disease : JAD 2006;9(2):195-205.
2005: Walter Hubl; Martina Zogbaum; James C Boyd; John Savory; Mary Schubert; Dirk Meyer; Thomas Demant
Evaluation of analytical methods and workflow performance of the Architect ci8200 integrated serum/plasma analyzer system.
Clinica chimica acta; international journal of clinical chemistry 2005;357(1):43-54.
2004: Kathleen J S Griffioen; Othman Ghribi; Nena Fox; John Savory; David A DeWitt
Aluminum maltolate-induced toxicity in NT2 cells occurs through apoptosis and includes cytochrome c release.
Neurotoxicology 2004;25(5):859-67.
2004: Othman Ghribi; Mary M Herman; Patcharin Pramoonjago; Natalie K Spaulding; John Savory
GDNF regulates the A beta-induced endoplasmic reticulum stress response in rabbit hippocampus by inhibiting the activation of gadd 153 and the JNK and ERK kinases.
Neurobiology of disease 2004;16(2):417-27.
2003: Othman Ghribi; Patcharin Prammonjago; Mary M Herman; Natalie K Spaulding; John Savory
Abeta(1-42)-induced JNK and ERK activation in rabbit hippocampus is differentially regulated by lithium but is not involved in the phosphorylation of tau.
Brain research. Molecular brain research 2003;119(2):201-6.
2003: Othman Ghribi; Mary M Herman; Patcharin Pramoonjago; John Savory
MPP+ induces the endoplasmic reticulum stress response in rabbit brain involving activation of the ATF-6 and NF-kappaB signaling pathways.
Journal of neuropathology and experimental neurology 2003;62(11):1144-53.
2003: John Savory; Mary M Herman; Othman Ghribi
Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain.
Journal of inorganic biochemistry 2003;97(1):151-4.
2003: John Savory
F. William Sunderman MD, PhD (1898-2003).
Clinical chemistry 2003;49(7):1235-7.
2003: Othman Ghribi; Mary M Herman; John Savory
Lithium inhibits Abeta-induced stress in endoplasmic reticulum of rabbit hippocampus but does not prevent oxidative damage and tau phosphorylation.
Journal of neuroscience research 2003;71(6):853-62.
2003: Christopher P Holstege; Yvonne Hunter; Alexander B Baer; John Savory; David Bruns; James C Boyd
Massive caffeine overdose requiring vasopressin infusion and hemodialysis.
Journal of toxicology. Clinical toxicology 2003;41(7):1003-7.
2002: John Savory; Othman Ghribi; Mary M Herman
Is amyloid beta-peptide neurotoxic or neuroprotective and what is its role in the binding of metal ions?
Neurobiology of aging 2002;23(6):1089-92.
2002: Othman Ghribi; Mary M Herman; Natalie K Spaulding; John Savory
Lithium inhibits aluminum-induced apoptosis in rabbit hippocampus, by preventing cytochrome c translocation, Bcl-2 decrease, Bax elevation and caspase-3 activation.
Journal of neurochemistry 2002;82(1):137-45.
2002: Othman Ghribi; Mary M Herman; John Savory
The endoplasmic reticulum is the main site for caspase-3 activation following aluminum-induced neurotoxicity in rabbit hippocampus.
Neuroscience letters 2002;324(3):217-21.
2002: Michael S Forbes; Othman Ghribi; Mary M Herman; John Savory
Aluminum-induced dendritic pathology revisited: cytochemical and electron microscopic studies of rabbit cortical pyramidal neurons.
Annals of clinical and laboratory science 2002;32(1):75-86.
2001: Othman Ghribi; Mary M Herman; David A DeWitt; Michael S Forbes; John Savory
Abeta(1-42) and aluminum induce stress in the endoplasmic reticulum in rabbit hippocampus, involving nuclear translocation of gadd 153 and NF-kappaB.
Brain research. Molecular brain research 2001;96(1-2):30-8.
2001: John Savory; Othman Ghribi; Michael S Forbes; Mary M Herman
Aluminium and neuronal cell injury: inter-relationships between neurofilamentous arrays and apoptosis.
Journal of inorganic biochemistry 2001;87(1-2):15-9.
2001: Othman Ghribi; Mary M Herman; Michael S Forbes; David A DeWitt; John Savory
GDNF protects against aluminum-induced apoptosis in rabbits by upregulating Bcl-2 and Bcl-XL and inhibiting mitochondrial Bax translocation.
Neurobiology of disease 2001;8(5):764-73.
2001: Othman Ghribi; David A DeWitt; Michael S Forbes; Mary M Herman; John Savory
Co-involvement of mitochondria and endoplasmic reticulum in regulation of apoptosis: changes in cytochrome c, Bcl-2 and Bax in the hippocampus of aluminum-treated rabbits.
Brain research 2001;903(1-2):66-73.
2001: James C Boyd; John Savory
Genetic algorithm for scheduling of laboratory personnel.
Clinical chemistry 2001;47(1):118-23.
1999: John Savory; JK Rao; Yueming Huang; P R Letada; Mary M Herman
Age-related hippocampal changes in Bcl-2:Bax ratio, oxidative stress, redox-active iron and apoptosis associated with aluminum-induced neurodegeneration: increased susceptibility with aging.
Neurotoxicology 1999;20(5):805-17.
1999: John Savory; Mary M Herman
Advances in instrumental methods for the measurement and speciation of trace metals.
Annals of clinical and laboratory science 1999;29(2):118-26.
1998: JK Rao; C D Katsetos; Mary M Herman; John Savory
Experimental aluminum encephalomyelopathy. Relationship to human neurodegenerative disease.
Clinics in laboratory medicine 1998;18(4):687-98, viii.
1998: PL Lynch; David Bruns; James C Boyd; John Savory
Chiron 800 system CO-oximeter module overestimates methemoglobin concentrations in neonatal samples containing fetal hemoglobin.
Clinical chemistry 1998;44(7):1569-70.
1998: JK Rao; P Letada; Doris M Haverstick; Mary M Herman; John Savory
Modifications to the in situ TUNEL method for detection of apoptosis in paraffin-embedded tissue sections.
Annals of clinical and laboratory science 1998;28(3):131-7.
1998: John Savory; Yueming Huang; M R Wills; Mary M Herman
Reversal by desferrioxamine of tau protein aggregates following two days of treatment in aluminum-induced neurofibrillary degeneration in rabbit: implications for clinical trials in Alzheimer's disease.
Neurotoxicology 1998;19(2):209-14.
1998: PL Lynch; John Savory; Doris M Haverstick
Urine total protein measurement with the Vitros dry reagent technology: modification of diluent to resolve positive bias of diluted samples.
Clinical chemistry 1998;44(3):674-5.
1997: Yueming Huang; Mary M Herman; J Liu; C D Katsetos; M R Wills; John Savory
Neurofibrillary lesions in experimental aluminum-induced encephalopathy and Alzheimer's disease share immunoreactivity for amyloid precursor protein, A beta, alpha 1-antichymotrypsin and ubiquitin-protein conjugates.
Brain research 1997;771(2):213-20.
1996: J C Boyd; Robin A Felder; John Savory
Robotics and the changing face of the clinical laboratory.
Clinical chemistry 1996;42(12):1901-10.
1996: John Savory; Christopher Exley; W F Forbes; Yueming Huang; J G Joshi; T Kruck; D R McLachlan; I Wakayama
Can the controversy of the role of aluminum in Alzheimer's disease be resolved? What are the suggested approaches to this controversy and methodological issues to be considered?
Journal of toxicology and environmental health 1996;48(6):615-35.
1996: John Savory; Yueming Huang; M M Herman; M R Wills
Quantitative image analysis of temporal changes in tau and neurofilament proteins during the course of acute experimental neurofibrillary degeneration; non-phosphorylated epitopes precede phosphorylation.
Brain research 1996;707(2):272-81.
1995: Robin A Felder; John Savory; K S Margrey; J W Holman; J C Boyd
Development of a robotic near patient testing laboratory.
Archives of pathology & laboratory medicine 1995;119(10):948-51.
1995: R T Erasmus; J Kusnir; W C Stevenson; Peter I Lobo; M M Herman; M R Wills; John Savory
Hyperaluminemia associated with liver transplantation and acute renal failure.
Clinical transplantation 1995;9(4):307-11.
1995: John Savory; Yueming Huang; M M Herman; M R Reyes; M R Wills
Tau immunoreactivity associated with aluminum maltolate-induced neurofibrillary degeneration in rabbits.
Brain research 1995;669(2):325-9.
1995: Yueming Huang; John Savory; M M Herman; J R Nicholson; M R Reyes; J C Boyd; M R Wills
Quantitative evaluation of Al maltolate-induced neurodegeneration with subsequent Al removal by desferrioxamine treatment.
Neurotoxicology 1995;16(2):291-6.
1994: John Savory; M M Herman; R T Erasmus; J C Boyd; M R Wills
Partial reversal of aluminium-induced neurofibrillary degeneration by desferrioxamine in adult male rabbits.
Neuropathology and applied neurobiology 1994;20(1):31-7.
1993: R T Erasmus; John Savory; M R Wills; M M Herman
Aluminum neurotoxicity in experimental animals.
Therapeutic drug monitoring 1993;15(6):588-92.
1993: M R Wills; C D Hewitt; John Savory; M M Herman
Long-term oral aluminum administration in rabbits. II. Brain and other organs.
Annals of clinical and laboratory science 1993;23(1):17-23.
1993: John Savory; M M Herman; J C Hundley; R L Seward; C M Griggs; Christos D Katsetos; M R Wills
Quantitative studies on aluminum deposition and its effects on neurofilament protein expression and phosphorylation, following the intraventricular administration of aluminum maltolate to adult rabbits.
Neurotoxicology 1993;14(1):9-12.
1993: M R Wills; C D Hewitt; B C Sturgill; John Savory; M M Herman
Long-term oral or intravenous aluminum administration in rabbits. I. Renal and hepatic changes.
Annals of clinical and laboratory science 1993;23(1):1-16.
1992: John Savory; M R Wills
Trace metals: essential nutrients or toxins.
Clinical chemistry 1992;38(8B Pt 2):1565-73.
1992: C D Hewitt; D J Innes; M M Herman; John Savory; M R Wills
Hematological changes after long-term aluminum administration to normal adult rabbits.
Annals of clinical and laboratory science 1992;22(2):85-94.
1991: Robin A Felder; J C Boyd; K S Margrey; W Holman; J Roberts; John Savory
Robots in health care.
Analytical chemistry 1991;63(14):741A-747A.
1991: C D Hewitt; M M Herman; M Beatriz S Lopes; John Savory; M R Wills
Aluminium maltol-induced neurocytoskeletal changes in fetal rabbit midbrain in matrix culture.
Neuropathology and applied neurobiology 1991;17(1):47-60.
1990: Christos D Katsetos; John Savory; M M Herman; R M Carpenter; Anthony Frankfurter; C D Hewitt; M R Wills
Neuronal cytoskeletal lesions induced in the CNS by intraventricular and intravenous aluminium maltol in rabbits.
Neuropathology and applied neurobiology 1990;16(6):511-28.
1990: Robin A Felder; J C Boyd; John Savory
Clinical laboratory robots: their impact on laboratory management.
Clinical laboratory management review : official publication of the Clinical Laboratory Management Association / CLMA 1990;4(6):449-54.
1990: Robin A Felder; J C Boyd; K Margrey; W Holman; John Savory
Robotics in the medical laboratory.
Clinical chemistry 1990;36(9):1534-43.
1990: C D Hewitt; K Winborne; D Margrey; J R Nicholson; M G Savory; John Savory; M R Wills
Critical appraisal of two methods for determining aluminum in blood samples.
Clinical chemistry 1990;36(8 Pt 1):1466-9.
1990: C D Hewitt; John Savory; M R Wills
Aspects of aluminum toxicity.
Clinics in laboratory medicine 1990;10(2):403-22.
1990: Suresh Aggarwal; Michael Kinter; M R Wills; John Savory; David A Herold
Determination of chromium in urine by stable isotope dilution gas chromatography/mass spectrometry using lithium bis(trifluoroethyl)dithiocarbamate as a chelating agent.
Analytical chemistry 1990;62(2):111-5.
1989: David A Herold; B J Smith; R M Ross; F Marquis; John Savory; M R Wills; C R Ayers
Measurement of plasma thromboxane B2 by gas chromatography-mass spectrometry using 18O2-labelled thromboxane B2 as the internal standard.
Journal of chromatography 1989;496(1):180-8.
1989: C D Hewitt; D J Innes; John Savory; M R Wills
Normal biochemical and hematological values in New Zealand white rabbits.
Clinical chemistry 1989;35(8):1777-9.
1989: R L Bertholf; M M Herman; John Savory; R M Carpenter; B C Sturgill; Christos D Katsetos; Scott R Vandenberg; M R Wills
A long-term intravenous model of aluminum maltol toxicity in rabbits: tissue distribution, hepatic, renal, and neuronal cytoskeletal changes associated with systemic exposure.
Toxicology and applied pharmacology 1989;98(1):58-74.
1989: J R Nicholson; M G Savory; John Savory; M R Wills
Micro-quantity tissue digestion for metal measurements by use of a microwave acid-digestion bomb.
Clinical chemistry 1989;35(3):488-90.
1989: M R Wills; John Savory
Aluminum and chronic renal failure: sources, absorption, transport, and toxicity.
Critical reviews in clinical laboratory sciences 1989;27(1):59-107.
1989: David Bruns; A L Boskey; W Lieb; Brian P Conway; John Savory; M R Wills
Tumoral calcinosis: seasonal biochemical studies and chemical studies of eyelid lesion.
Clinical chemistry 1989;35(1):183-5.
1988: Robin A Felder; J C Boyd; John Savory; K Margrey; A Martinez; D Vaughn
Robotics in the clinical laboratory.
Clinics in laboratory medicine 1988;8(4):699-711.
1988: Michael Kinter; J R Shipe; John Savory
Tandem mass spectrometry in drug-abuse testing, exemplified for anabolic steroids.
Clinical chemistry 1988;34(10):2178.
1988: R L Bertholf; M G Savory; K H Winborne; J C Hundley; G M Plummer; John Savory
Lithium determined in serum with an ion-selective electrode.
Clinical chemistry 1988;34(7):1500-2.
1988: Daniel J Cox; M E Moll; Linda Gonder-Frederick; John Savory; S Jones-Garrison
Accuracy of time-delayed filter-paper blood glucose determination.
Diabetes care 1988;11(6):517-8.
1988: David Bruns; W Lieb; Brian P Conway; John Savory; M R Wills; A L Boskey
Band keratopathy and calcific lid lesions in tumoral calcinosis. Case reports.
Archives of ophthalmology 1988;106(6):725-6.
1988: Michael Kinter; David A Herold; J Hundley; M R Wills; John Savory
Measurement of cholesterol in serum by gas chromatography/mass spectrometry at moderate mass resolution, with a nonendogenous cholesterol isomer as internal standard.
Clinical chemistry 1988;34(3):531-4.
1988: John Savory; M R Wills
Methodological aspects of trace element determination.
Contributions to nephrology 1988;64():144-50.
1987: R L Bertholf; J R Nicholson; M R Wills; John Savory
Measurement of lipid peroxidation products in rabbit brain and organs (response to aluminum exposure).
Annals of clinical and laboratory science 1987;17(6):418-23.
1987: David A Herold; B J Smith; R M Ross; G Redpath; A Arlinghaus; M R Wills; John Savory
Measurement of plasma prostaglandin F2 alpha using capillary gas chromatography negative ion chemical ionization mass spectrometry.
Annals of clinical and laboratory science 1987;17(5):300-5.
1985: John Savory; R G Stallings; David Bruns; M G Savory; M Margrey; J C Boyd
Optimization and evaluation of cardiac enzymes and isoenzymes measured on a random access analyzer.
Annals of clinical and laboratory science 1985;15(5):400-5.
1985: John Savory; K S Margrey; J R Shipe; M G Savory; M H Margrey; T E Mifflin; M R Wills; J C Boyd
Stabilization of the calmagite reagent for automated measurement of magnesium in serum and urine.
Clinical chemistry 1985;31(3):487-8.
1985: J C Boyd; M G Savory; M Margrey; David A Herold; J R Shipe; John Savory
Adaptation of EMIT drug assays to a random-access automated clinical analyzer.
Annals of clinical and laboratory science 1985;15(1):39-44.
1984: M Margrey; K Margrey; David Bruns; J C Boyd; G A Fortier; B W Renoe; John Savory
Enzymatic assay for creatinine with fixed-time kinetics on a centrifugal analyzer.
Annals of clinical and laboratory science 1984;14(4):298-303.