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Akira Sawa

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Daisuke Ibi; Kozo Kaibuchi; Shin-Ichi Kano; Takahiro Kawase; Ulrike C Lange; Hiroyuki Mizoguchi; Toshitaka Nabeshima; Taku Nagai; Akira Nakajima; Yoshiaki Sato; Takaya Satoh; Akira Sawa; M Azim Surani; Daisuke Tsuboi; David J Adams; Masahiro Hayakawa; Kiyofumi Yamada
Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice.
Takeshi Sakurai; Leslie A Shinobu; Akira Sawa
Schizophrenia research in 2013: are we making progress?
Saurav Seshadri; Mariela Zeledon; Akira Sawa
Synapse-specific contributions in the cortical pathology of schizophrenia.

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2013: Daisuke Ibi; Kozo Kaibuchi; Shin-Ichi Kano; Takahiro Kawase; Ulrike C Lange; Hiroyuki Mizoguchi; Toshitaka Nabeshima; Taku Nagai; Akira Nakajima; Yoshiaki Sato; Takaya Satoh; Akira Sawa; M Azim Surani; Daisuke Tsuboi; David J Adams; Masahiro Hayakawa; Kiyofumi Yamada
Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice.
Glia 2013;61(5):679-93.
2013: Takeshi Sakurai; Leslie A Shinobu; Akira Sawa
Schizophrenia research in 2013: are we making progress?
Neurobiology of disease 2013;53():1-2.
2013: Saurav Seshadri; Mariela Zeledon; Akira Sawa
Synapse-specific contributions in the cortical pathology of schizophrenia.
Neurobiology of disease 2013;53():26-35.
2013: T M Ma; Jun Nomura; B Abazyan; S Abazyan; Akira Sawa; S Seshadri; Solomon H Snyder; C Yang; Jun Nomura
Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion.
Molecular psychiatry 2013;18(5):557-67.
2013: Hanna Jaaro-Peled; Atsushi Kamiya; Yolanda Mateo; Rina Murai; Toshitaka Nabeshima; Minae Niwa; Patricio O'Donnell; Martin G Pomper; Nicola G Cascella; Samantha de Los Reyes; Catherine A Foss; Tomás R Guilarte; Akira Sawa
Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imaging.
Human molecular genetics 2013;22(8):1574-80.
2013: Minae Niwa; Norio Ozaki; Saurav Seshadri; Stephanie Tankou; Nicola G Cascella; Takatoshi Hikida; Hanna Jaaro-Peled; Shin-ichi Kano; Yurie Matsumoto; Toshitaka Nabeshima; Akira Sawa
Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids.
Science (New York, N.Y.) 2013;339(6117):335-9.
2013: M A Kondo; N Matsuoka; K Ni; Jonathan Pevsner; S Pou; S Seshadri; KATSUNORI TAJINDA; Carlo Colantuoni; K Furukori; K Harada; H Hiyama; C Hookway; B Huang; H Jaaro-Peled; S-i Kano; Akira Sawa
Unique pharmacological actions of atypical neuroleptic quetiapine: possible role in cell cycle/fate control.
Translational psychiatry 2013;3():e243.
2013: J M Coughlin; E L Daley; J A Edwards; Koko Ishizuka; S I Kano; F. Markus Leweke; Martin G Pomper; F T Seifuddin; M A Shimano; Robert H Yolken; Peter P Zandi; Nicola G Cascella; Akira Sawa
Marked reduction of soluble superoxide dismutase-1 (SOD1) in cerebrospinal fluid of patients with recent-onset schizophrenia.
Molecular psychiatry 2013;18(1):10-1.
2012: Takatoshi Hikida; Nao J Gamo; Akira Sawa
DISC1 as a therapeutic target for mental illnesses.
Expert opinion on therapeutic targets 2012;16(12):1151-60.
2012: Yoichiro Takayanagi; Akira Sawa; Nicola G Cascella; William W Eaton
Diabetes is associated with lower global cognitive function in schizophrenia.
Schizophrenia research 2012;142(1-3):183-7.
2012: Rana Rais; Camilo Rojas; Akira Sawa; Barbara Slusher; Christine A Strick; Ajit G Thomas; Nicholas J Brandon; Sandra J Engle; Hanna Jaaro-Peled; Krystyna Wozniak; Ying Wu; Takashi Tsukamoto
Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(11):2067-73.
2012: Verian Bader; Nicholas J Bradshaw; Jesper Ekelund; Stefano Ferrea; William Hennah; Uwe Henning; Maria Hipolito; Koko Ishizuka; Marjo-Riitta Järvelin; S Rutger Leliveld; Chi-Ying Lin; Christian Luckhaus; Evaristus Nwulia; Ingrid Prikulis; Narayan Rai; Adriana Ramos; Jesús R Requena; Isaac Rosa; Akira Sawa; Liisa Tomppo; Svenja V Trossbach; Juha Veijola; Ángel García; Carsten Korth
Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits.
Human molecular genetics 2012;21(20):4406-18.
2012: Anna Terrin; Anna Zoccarato; Niove E Jordanides; Andreas Koschinski; Marco Mongillo; Stefania Monterisi; joanne mountford; Akira Sawa; Alessandra Stangherlin; Nicoletta Concetta Surdo; Manuela Zaccolo
PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome.
The Journal of cell biology 2012;198(4):607-21.
2012: Akihiro Mouri; Shin-Ichi Kano; Takenao Koseki; Takayoshi Mamiya; Shiho Narusawa; Minae Niwa; Akira Sawa; Toshitaka Nabeshima
Mouse strain differences in phencyclidine-induced behavioural changes.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2012;15(6):767-79.
2012: Neelam Shahani; Akira Sawa
Protein S-nitrosylation: role for nitric oxide signaling in neuronal death.
Biochimica et biophysica acta 2012;1820(6):736-42.
2012: Christelle Golzio; James F Gusella; Sébastien Jacquemont; Atsushi Kamiya; Edwin C Oh; Alexandre Reymond; Akira Sawa; Mei Sun; Michael E Talkowski; Yu Taniguchi; Jason Willer; Jacques Beckmann; Nicholas Katsanis
KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant.
Nature 2012;485(7398):363-7.
2012: XIAOJU YANG; Erin R Ewald; Yuqing Huo; Roberto Salvatori; Akira Sawa; Kellie L K Tamashiro; Gary S Wand; Richard S Lee
Glucocorticoid-induced loss of DNA methylation in non-neuronal cells and potential involvement of DNMT1 in epigenetic regulation of Fkbp5.
Biochemical and biophysical research communications 2012;420(3):570-5.
2012: Yu Taniguchi; Tracy Young-Pearse; Akira Sawa; Atsushi Kamiya
In utero electroporation as a tool for genetic manipulation in vivo to study psychiatric disorders: from genes to circuits and behaviors.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2012;18(2):169-79.
2012: Chi-Ying Lin; Akira Sawa; Hanna Jaaro-Peled
Better understanding of mechanisms of schizophrenia and bipolar disorder: from human gene expression profiles to mouse models.
Neurobiology of disease 2012;45(1):48-56.
2011: Nicholas J Brandon; Akira Sawa
Linking neurodevelopmental and synaptic theories of mental illness through DISC1.
Nature reviews. Neuroscience 2011;12(12):707-22.
2011: David J Porteous; Nicholas J Brandon; J Kirsty Millar; Akira Sawa
DISC1 at 10: connecting psychiatric genetics and neuroscience.
Trends in molecular medicine 2011;17(12):699-706.
2011: Rita Sattler; Akira Sawa; Yoko Ayukawa; David Block; Richard Chipkin; Luke Coddington; Jeffrey rothstein
Human nasal olfactory epithelium as a dynamic marker for CNS therapy development.
Experimental neurology 2011;232(2):203-11.
2011: Nicola G Cascella; Shaina C Fieldstone; Gwendolyn J Gerner; Akira Sawa; David J Schretlen
The insula-claustrum region and delusions in schizophrenia.
Schizophrenia research 2011;133(1-3):77-81.
2011: Mari Kondo; Akira Sawa
Anti-/Propsychotic drug signaling via heteromeric GPCRs--a balancing act?
Cell 2011;147(5):964-5.
2011: Taku Nagai; Akira Sawa; Daisuke Ibi; Yuko Kitahara; Toshitaka Nabeshima; Kiyofumi Yamada
Effects of antipsychotics on the behavioral deficits in human dominant-negative DISC1 transgenic mice with neonatal polyI:C treatment.
Behavioural brain research 2011;225(1):305-10.
2011: Shin-ichi Kano; Minae Niwa; Evaristus Nwulia; Akira Sawa; Yian Chen; Nicola G Cascella
Altered MHC class I expression in dorsolateral prefrontal cortex of nonsmoker patients with schizophrenia.
Neuroscience research 2011;71(3):289-93.
2011: Stephen R Marder; Bita Moghaddam; Eric J Nestler; Bryan Roth; Akira Saw; Edward M Scolnick; Patrick F Sullivan; Daniel R Welnberger; Akira Sawa; Schahram Akbarian; John A Allen; Robert W Buchanan; Brian Campbell; Marc G Caron; P Jeffrey Conn; Susan R George; Mark A Geyer; Jay A Gingrich; Alessandro Guidotti; Stephen J Haggarty; Maria Karayiorgou; John H Krystal; Amanda J Law; Jeffrey A Lieberman; Michelle Solis
Advancing drug discovery for schizophrenia.
Annals of the New York Academy of Sciences 2011;1236():30-43.
2011: Q Wang; R J Weinberg; Y Xie; Z Yan; B Bates; Erik I Charych; R A Crozier; A J Dunlop; N M Graziane; A Hayashi-Takagi; M D Houslay; Koko Ishizuka; K Kariya; M P Kelly; J B Lee; Stephen J Moss; Hannah Murdoch; M Pausch; Virginia L Pulito; Raquel Revilla-Sanchez; Akira Sawa; S Seshadri; N Taylor; N J Brandon
The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function.
Molecular psychiatry 2011;16(10):1006-23.
2011: Rafael Flores; Yuki Hirota; Akira Sawa; Brian Armstrong; Toshifumi Tomoda
DISC1 regulates synaptic vesicle transport via a lithium-sensitive pathway.
Neuroscience research 2011;71(1):71-7.
2011: Eiichiro Nagata; Yoshinori Okada; Adolfo Saiardi; Tadayuki Satoh; Akira Sawa; Johbu Itoh; Yoshiko Itoh; Russell L Margolis; Shunya Takizawa; Hideo Tsukamoto; Shigeharu Takagi
Inositol hexakisphosphate kinases induce cell death in Huntington disease.
The Journal of biological chemistry 2011;286(30):26680-6.
2011: Minori Koga; Marcus M Messmer; Akira Sawa; Akiko Hayashi-Takagi; Lynda D Hester; Anthony V Serritella; Solomon H Snyder; Thomas W Sedlak
Glutathione is a physiologic reservoir of neuronal glutamate.
Biochemical and biophysical research communications 2011;409(4):596-602.
2011: Sandra P Zoubovsky; Vladimir M Pogorelov; Yu Taniguchi; Sun-Hong Kim; Peter Yoon; Evaristus Nwulia; Akira Sawa; Mikhail V Pletnikov; Atsushi Kamiya
Working memory deficits in neuronal nitric oxide synthase knockout mice: potential impairments in prefrontal cortex mediated cognitive function.
Biochemical and biophysical research communications 2011;408(4):707-12.
2011: Koko Ishizuka; Atsushi Kamiya; Edwin C Oh; Hiroaki Kanki; Saurav Seshadri; Jon F Robinson; Hannah Murdoch; Allan J Dunlop; Ken-ichiro Kubo; Keiko Furukori; Beverly Huang; Mariela Zeledon; Akiko Hayashi-Takagi; Hideyuki Okano; Kazunori Nakajima; Miles D Houslay; Nicholas Katsanis; Akira Sawa
DISC1-dependent switch from progenitor proliferation to migration in the developing cortex.
Nature 2011;473(7345):92-6.
2011: Neelam Shahani; Akira Sawa
Nitric oxide signaling and nitrosative stress in neurons: role for S-nitrosylation.
Antioxidants & redox signaling 2011;14(8):1493-504.
2011: Amy J Ramsey; Marija Milenkovic; Ana F Oliveira; Yasmin Escobedo-Lozoya; Saurav Seshadri; Ali Salahpour; Akira Sawa; Ryohei Yasuda; Marc G Caron
Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(14):5795-800.
2011: Akiko Hayashi-Takagi; Peter B Barker; Akira Sawa
Readdressing synaptic pruning theory for schizophrenia: Combination of brain imaging and cell biology.
Communicative & integrative biology 2011;4(2):211-2.
2011: Y Ayhan; B Abazyan; Jun Nomura; R Kim; Bruce Ladenheim; I N Krasnova; Akira Sawa; Russell L Margolis; Jean Lud Cadet; Susumu Mori; Michael W Vogel; Christopher A Ross; Jun Nomura
Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders.
Molecular psychiatry 2011;16(3):293-306.
2011: Yuji Ozeki; Benjamin S Pickard; Shin-ichi Kano; Mary P Malloy; Mariela Zeledon; Daniel Q Sun; Kumiko Fujii; Keiko Wakui; Yukihiko Shirayama; Yoshimitsu Fukushima; Hiroshi Kunugi; Kenji Hashimoto; Walter J Muir; Douglas H Blackwood; Akira Sawa
A novel balanced chromosomal translocation found in subjects with schizophrenia and schizotypal personality disorder: altered l-serine level associated with disruption of PSAT1 gene expression.
Neuroscience research 2011;69(2):154-60.
2011: Carlos Tristan; Neelam Shahani; Thomas W Sedlak; Akira Sawa
The diverse functions of GAPDH: views from different subcellular compartments.
Cellular signalling 2011;23(2):317-23.
2011: Kevin J Mitchell; Bita Moghaddam; Z Josh Huang; Akira Sawa
Following the genes: a framework for animal modeling of psychiatric disorders.
BMC biology 2011;9():76.
2010: Bagrat Abazyan; Jun Nomura; Geetha Kannan; Koko Ishizuka; Kellie L K Tamashiro; Frederick C Nucifora; Vladimir Pogorelov; Bruce Ladenheim; Chunxia Yang; Irina N Krasnova; Jean Lud Cadet; CARLOS PARDO-VILLAMIZAR; Susumu Mori; Atsushi Kamiya; Michael W Vogel; Akira Sawa; Christopher A Ross; Jun Nomura
Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology.
Biological psychiatry 2010;68(12):1172-81.
2010: Tatiana Lipina; M Niwa; H Jaaro-Peled; P J Fletcher; P Seeman; Akira Sawa; John C Roder
Enhanced dopamine function in DISC1-L100P mutant mice: implications for schizophrenia.
Genes, brain, and behavior 2010;9(7):777-89.
2010: Akiko Hayashi-Takagi; Akira Sawa
Disturbed synaptic connectivity in schizophrenia: convergence of genetic risk factors during neurodevelopment.
Brain research bulletin 2010;83(3-4):140-6.
2010: Tracy L Young-Pearse; Seiyam Suth; Eric S Luth; Akira Sawa; Dennis J Selkoe
Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(31):10431-40.
2010: Mirian A F Hayashi; Juliano R Guerreiro; Erik Charych; Atsushi Kamiya; Rosicler L Barbosa; Maurício F Machado; Joana D Campeiro; Vitor Oliveira; Akira Sawa; Antonio C M Camargo; Nicholas J Brandon
Assessing the role of endooligopeptidase activity of Ndel1 (nuclear-distribution gene E homolog like-1) in neurite outgrowth.
Molecular and cellular neurosciences 2010;44(4):353-61.
2010: Nicola G Cascella; Shaina C Fieldstone; Vani Rao; Godfrey D Pearlson; Akira Sawa; David J Schretlen
Gray-matter abnormalities in deficit schizophrenia.
Schizophrenia research 2010;120(1-3):63-70.
2010: David J Schretlen; Tracy Vannorsdall; Jessica M Winicki; Yaser Mushtaq; Takatoshi Hikida; Akira Sawa; Robert H Yolken; Faith B Dickerson; Nicola G Cascella
Neuroanatomic and cognitive abnormalities related to herpes simplex virus type 1 in schizophrenia.
Schizophrenia research 2010;118(1-3):224-31.
2010: Xiao-Ming Ou; Craig A Stockmeier; Herbert Y Meltzer; James C Overholser; George J Jurjus; Lesa Dieter; Kevin Chen; Deyin Lu; Chandra Johnson; Moussa B H Youdim; Mark C Austin; Jia Luo; Akira Sawa; Warren May; Jean C Shih
A novel role for glyceraldehyde-3-phosphate dehydrogenase and monoamine oxidase B cascade in ethanol-induced cellular damage.
Biological psychiatry 2010;67(9):855-63.
2010: Saurav Seshadri; Atsushi Kamiya; Yukako Yokota; Ingrid Prikulis; Shin-ichi Kano; Akiko Hayashi-Takagi; Amelia Stanco; Tae-Yeon Eom; Sarada Rao; Koko Ishizuka; Philip C Wong; Carsten Korth; E S Anton; Akira Sawa
Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(12):5622-7.
2010: KATSUNORI TAJINDA; Koko Ishizuka; Carlo Colantuoni; M Morita; J Winicki; C Le; Sandra Y Lin; David J Schretlen; Akira Sawa; Nicola G Cascella
Neuronal biomarkers from patients with mental illnesses: a novel method through nasal biopsy combined with laser-captured microdissection.
Molecular psychiatry 2010;15(3):231-2.
2010: Akiko Hayashi-Takagi; Manabu Takaki; Nick Graziane; Saurav Seshadri; Hannah Murdoch; Allan J Dunlop; Yuichi Makino; Anupamaa J Seshadri; Koko Ishizuka; Deepak P Srivastava; Zhong Xie; Jay M Baraban; Miles D Houslay; Toshifumi Tomoda; Nicholas J Brandon; Atsushi Kamiya; Zhen Yan; Peter Penzes; Akira Sawa
Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1.
Nature neuroscience 2010;13(3):327-32.
2010: Hanna Jaaro-Peled; Yavuz Ayhan; Mikhail V Pletnikov; Akira Sawa
Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and nongenetic models.
Schizophrenia bulletin 2010;36(2):301-13.
2010: Minae Niwa; Atsushi Kamiya; Rina Murai; Ken-ichiro Kubo; Aaron J Gruber; Kenji Tomita; Lingling Lu; Shuta Tomisato; Hanna Jaaro-Peled; Saurav Seshadri; Hideki Hiyama; Beverly Huang; Kazuhisa Kohda; Yukihiro Noda; Patricio O'Donnell; Kazunori Nakajima; Akira Sawa; Toshitaka Nabeshima
Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits.
Neuron 2010;65(4):480-9.
2010: Daisuke Ibi; Taku Nagai; Hiroyuki Koike; Yuko Kitahara; Hiroyuki Mizoguchi; Minae Niwa; Hanna Jaaro-Peled; Atsumi Nitta; Yukio Yoneda; Toshitaka Nabeshima; Akira Sawa; Kiyofumi Yamada
Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood.
Behavioural brain research 2010;206(1):32-7.
2010: Koko Ishizuka; KATSUNORI TAJINDA; Carlo Colantuoni; Masahiko Morita; Jessica Winicki; Cindy Le; Sandra Y Lin; David J Schretlen; Akira Sawa; Nicola G Cascella
Negative symptoms of schizophrenia correlate with impairment on the University of Pennsylvania smell identification test.
Neuroscience research 2010;66(1):106-10.
2009: Yavuz Ayhan; Akira Sawa; Christopher A Ross; Mikhail V Pletnikov
Animal models of gene-environment interactions in schizophrenia.
Behavioural brain research 2009;204(2):274-81.
2009: Hidemitsu Nakajima; Wataru Amano; Takeya Kubo; Ayano Fukuhara; Hideshi Ihara; Yasu-Taka Azuma; Hisao Tajima; Takashi Inui; Akira Sawa; Tadayoshi Takeuchi
Glyceraldehyde-3-phosphate dehydrogenase aggregate formation participates in oxidative stress-induced cell death.
The Journal of biological chemistry 2009;284(49):34331-41.
2009: Hirotada Akiyama; Aina Gotoh; Ryong-Woon Shin; Tomoe Koga; Tsubasa Ohashi; Wataru Sakamoto; Akihiro Harada; Hiroyuki Arai; Akira Sawa; Chiyoko Uchida; Takafumi Uchida
A novel role for hGas7b in microtubular maintenance: possible implication in tau-associated pathology in Alzheimer disease.
The Journal of biological chemistry 2009;284(47):32695-9.
2009: Nicholas J Brandon; J Kirsty Millar; Carsten Korth; Hazel Sive; Karun K Singh; Akira Sawa
Understanding the role of DISC1 in psychiatric disease and during normal development.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(41):12768-75.
2009: Akira Sawa
Cortical development and glutamatergic dysregulation in schizophrenia.
Biological psychiatry 2009;66(6):530-2.
2009: Hanna Jaaro-Peled; Akiko Hayashi-Takagi; Saurav Seshadri; Atsushi Kamiya; Nicholas J Brandon; Akira Sawa
Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1.
Trends in neurosciences 2009;32(9):485-95.
2009: Pei-Chun Hsu; Evaristus Nwulia; Akira Sawa
Using bioinformatic tools.
The American journal of psychiatry 2009;166(8):854.
2009: Nilkantha Sen; Makoto R Hara; Abdullah Shafique Ahmad; Matthew B Cascio; Atsushi Kamiya; Jeffrey T Ehmsen; Nishant Agrawal; Nishant Aggrawal; Lynda D Hester; Sylvain Dore; Solomon H Snyder; Akira Sawa
GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation.
Neuron 2009;63(1):81-91.
2009: Akiko Goto; Yu-Lai Wang; Tomohiro Kabuta; Rieko Setsuie; Hitoshi Osaka; Akira Sawa; Shoichi Ishiura; Keiji Wada
Proteomic and histochemical analysis of proteins involved in the dying-back-type of axonal degeneration in the gracile axonal dystrophy (gad) mouse.
Neurochemistry international 2009;54(5-6):330-8.
2009: Nicola G Cascella; David J Schretlen; Akira Sawa
Schizophrenia and epilepsy: is there a shared susceptibility?
Neuroscience research 2009;63(4):227-35.
2009: Akira Sawa; Nicola G Cascella
Peripheral olfactory system for clinical and basic psychiatry: a promising entry point to the mystery of brain mechanism and biomarker identification in schizophrenia.
The American journal of psychiatry 2009;166(2):137-9.
2009: Akira Sawa
Genetic animal models for schizophrenia: advantages and limitations of genetic manipulation in drosophila, zebrafish, rodents, and primates.
Progress in brain research 2009;179():3-6.
2009: Akira Sawa
Preface. This volume focuses on how genetic models for schizophrenia, that is, manipulation in genetic susceptibility factors for the disease, have potential in opening a new window of better understanding of etiology-relevant mechanisms.
Progress in brain research 2009;179():vii.
2008: N Sawamura; T Ando; Y Maruyama; M Fujimuro; H Mochizuki; K Honjo; M Shimoda; H Toda; T Sawamura-Yamamoto; L A Makuch; A Hayashi; Koko Ishizuka; Nicola G Cascella; Atsushi Kamiya; N Ishida; T Tomoda; T Hai; K Furukubo-Tokunaga; Akira Sawa
Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly.
Molecular psychiatry 2008;13(12):1138-48, 1069.
2008: Atsushi Kamiya; Perciliz L Tan; Ken-ichiro Kubo; Caitlin Engelhard; Koko Ishizuka; Akiharu Kubo; Sachiko Tsukita; Ann E Pulver; Kazunori Nakajima; Nicola G Cascella; Nicholas Katsanis; Akira Sawa
Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses.
Archives of general psychiatry 2008;65(9):996-1006.
2008: Katherine Burdick; Atsushi Kamiya; Colin A Hodgkinson; Todd Lencz; Pamela DeRosse; Koko Ishizuka; Sarah Elashvili; Hiroyuki Arai; David Goldman; Akira Sawa; Anil Malhotra
Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding.
Human molecular genetics 2008;17(16):2462-73.
2008: Nilkantha Sen; Makoto R Hara; Michael D Kornberg; Matthew Cascio; Byoung-Il Bae; Neelam Shahani; Bobby Thomas; Ted M Dawson; Valina Dawson; Solomon H Snyder; Akira Sawa
Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis.
Nature cell biology 2008;10(7):866-73.
2008: Takatoshi Hikida; Asif K Mustafa; Kazuhisa Maeda; Kumiko Fujii; Roxanne K Barrow; Masoumeh Saleh; Richard Huganir; Solomon H Snyder; Kenji Hashimoto; Akira Sawa
Modulation of D-serine levels in brains of mice lacking PICK1.
Biological psychiatry 2008;63(10):997-1000.
2008: Atsushi Kamiya; Yasuji Kitabatake; Akira Sawa
[Neurodevelopmental disturbance in the pathogenesis of major mental disorders].
Brain and nerve = Shinkei kenkyū no shinpo 2008;60(4):445-52.
2008: Zhaohui Liu; Xiaoyue Wang; Yihua Bruce Yu; Xueping Li; Tao Wang; Haibing Jiang; Qiuting Ren; Yuchen Jiao; Akira Sawa; Timothy H Moran; Christopher A Ross; Craig Montell; Wanli Smith
A Drosophila model for LRRK2-linked parkinsonism.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2693-8.
2008: Fumie Yasumoto; A Hayashi; Atsushi Kamiya; T Negishi; Y Yoshikawa; Akira Sawa
Genetic manipulation of brain cultures from the primates: a novel tool for molecular studies of neuropsychiatric disorders.
Molecular psychiatry 2008;13(2):116-8.
2008: Qi Wang; Hanna Jaaro-Peled; Akira Sawa; Nicholas J Brandon
How has DISC1 enabled drug discovery?
Molecular and cellular neurosciences 2008;37(2):187-95.
2007: Kenji Hashimoto; Akira Sawa; Masaomi Iyo
Increased levels of glutamate in brains from patients with mood disorders.
Biological psychiatry 2007;62(11):1310-6.
2007: Robert E Feldmann; Akira Sawa; Günter H Seidler
Causality of stem cell based neurogenesis and depression--to be or not to be, is that the question?
Journal of psychiatric research 2007;41(9):713-23.
2007: Koko Ishizuka; J Chen; S Taya; W Li; J Kirsty Millar; Y Xu; Steven J Clapcote; C Hookway; M Morita; Atsushi Kamiya; T Tomoda; B K Lipska; John C Roder; Mikhail V Pletnikov; David J Porteous; A J Silva; T D Cannon; K Kaibuchi; Nicholas J Brandon; Daniel R Weinberger; Akira Sawa
Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice.
Molecular psychiatry 2007;12(10):897-9.
2007: Takatoshi Hikida; Hanna Jaaro-Peled; Saurav Seshadri; KENICHI OISHI; Caroline Hookway; Stephanie Kong; Di Wu; Rong Xue; Manuella Andradé; Stephanie Tankou; Susumu Mori; Michela Gallagher; Koko Ishizuka; Mikhail V Pletnikov; Satoshi Kida; Akira Sawa
Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(36):14501-6.
2007: Ryota Hashimoto; Stephanie Tankou; Masatoshi Takeda; Akira Sawa
Postsynaptic density: a key convergent site for schizophrenia susceptibility factors and possible target for drug development.
Drugs of today (Barcelona, Spain : 1998) 2007;43(9):645-54.
2007: Nicola G Cascella; Manabu Takaki; Sandra Y Lin; Akira Sawa
Neurodevelopmental involvement in schizophrenia: the olfactory epithelium as an alternative model for research.
Journal of neurochemistry 2007;102(3):587-94.
2007: Daisuke Matsuzawa; Kenji Hashimoto; Ryosuke Miyatake; Yukihiko Shirayama; Eiji Shimizu; Kazuhisa Maeda; Yoichi Suzuki; Yoichi Mashimo; Yoshimoto Sekine; Toshiya INADA; Norio Ozaki; Nakao Iwata; Mutsuo Harano; Tokutaro Komiyama; Mitsuhiko Yamada; Ichiro Sora; Hiroshi Ujike; Akira Hata; Akira Sawa; Masaomi Iyo
Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis.
The American journal of psychiatry 2007;164(7):1105-14.
2007: Mikhail V Pletnikov; Yanqun Xu; Mikhail V Ovanesov; Atsushi Kamiya; Akira Sawa; Christopher A Ross
PC12 cell model of inducible expression of mutant DISC1: new evidence for a dominant-negative mechanism of abnormal neuronal differentiation.
Neuroscience research 2007;58(3):234-44.
2006: Tsutomu Nishimura; Hideki Imai; Yoshio Minabe; Akira Sawa; Nobumasa Kato
Beneficial effects of FK506 for experimental temporal lobe epilepsy.
Neuroscience research 2006;56(4):386-90.
2006: Atsushi Kamiya; Toshifumi Tomoda; Jennifer Chang; Manabu Takaki; Caixin Zhan; Masahiko Morita; Matthew Cascio; Sarah Elashvili; Hiroyuki Koizumi; Yasukazu Takanezawa; Faith B Dickerson; Robert H Yolken; Hiroyuki Arai; Akira Sawa
DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1.
Human molecular genetics 2006;15(22):3313-23.
2006: Naoya Sawamura; Akira Sawa
Disrupted-in-schizophrenia-1 (DISC1): a key susceptibility factor for major mental illnesses.
Annals of the New York Academy of Sciences 2006;1086():126-33.
2006: Lyuda Bord; Jeff Wheeler; Matthew Paek; Masoumeh Saleh; Ariel Lyons-Warren; Christopher A Ross; Naoya Sawamura; Akira Sawa
Primate disrupted-in-schizophrenia-1 (DISC1): high divergence of a gene for major mental illnesses in recent evolutionary history.
Neuroscience research 2006;56(3):286-93.
2006: Kazuhisa Maeda; Evaristus A Nwulia; Jennifer Chang; Rishi Balkissoon; Koko Ishizuka; Haiming Chen; Peter P Zandi; Melvin G McInnis; Akira Sawa
Differential expression of disrupted-in-schizophrenia (DISC1) in bipolar disorder.
Biological psychiatry 2006;60(9):929-35.
2006: Ryota Hashimoto; Tadahiro Numakawa; Takashi Ohnishi; Emi Kumamaru; Yuki Yagasaki; Tetsuya Ishimoto; Takeyuki Mori; Kiyotaka Nemoto; Naoki Adachi; Aiko Izumi; Sachie Chiba; Hiroko Noguchi; Tatsuyo Suzuki; Nakao Iwata; Norio Ozaki; Takahisa Taguchi; Atsushi Kamiya; Asako Kosuga; Masahiko Tatsumi; Kunitoshi Kamijima; Daniel R Weinberger; Akira Sawa; Hiroshi Kunugi
Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling.
Human molecular genetics 2006;15(20):3024-33.
2006: Brian Kirkpatrick; Leyan Xu; Nicola G Cascella; Yuji Ozeki; Akira Sawa; Rosalinda C Roberts
DISC1 immunoreactivity at the light and ultrastructural level in the human neocortex.
The Journal of comparative neurology 2006;497(3):436-50.
2006: Koko Ishizuka; Matt Paek; Atsushi Kamiya; Akira Sawa
A review of Disrupted-In-Schizophrenia-1 (DISC1): neurodevelopment, cognition, and mental conditions.
Biological psychiatry 2006;59(12):1189-97.
2006: Makoto R Hara; Matthew Cascio; Akira Sawa
GAPDH as a sensor of NO stress.
Biochimica et biophysica acta 2006;1762(5):502-9.
2006: Barbara K Lipska; Tricia Peters; Thomas M Hyde; Nader D Halim; Cara Horowitz; Shruti N Mitkus; Cynthia Shannon Weickert; Mitsuyuki Matsumoto; Akira Sawa; Richard E Straub; Radhakrishna Vakkalanka; Mary M Herman; Daniel R Weinberger; Joel E Kleinman
Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs.
Human molecular genetics 2006;15(8):1245-58.
2006: Makoto R Hara; Bobby Thomas; Matthew Cascio; Byoung-Il Bae; Lynda D Hester; Valina Dawson; Ted M Dawson; Akira Sawa; Solomon H Snyder
Neuroprotection by pharmacologic blockade of the GAPDH death cascade.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(10):3887-9.
2006: Byoung-Il Bae; Makoto R Hara; Matthew Cascio; Cheryl L Wellington; Michael R Hayden; Christopher A Ross; Hyo Chol Ha; Xiao-Jiang Li; Solomon H Snyder; Akira Sawa
Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3405-9.
2006: K Joseph Hurt; Sena F Sezen; Hunter C Champion; Julie K Crone; Michael A Palese; Paul L Huang; Akira Sawa; Xiaojiang Luo; Biljana Musicki; Solomon H Snyder; Arthur L Burnett
Alternatively spliced neuronal nitric oxide synthase mediates penile erection.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3440-3.
2006: K Fujii; K Maeda; T Hikida; A K Mustafa; Rishi Balkissoon; Jun Xia; T Yamada; Y Ozeki; R Kawahara; M Okawa; Richard Huganir; H Ujike; Solomon H Snyder; Akira Sawa
Serine racemase binds to PICK1: potential relevance to schizophrenia.
Molecular psychiatry 2006;11(2):150-7.
2006: Yuji Tanaka; Shuichi Igarashi; Masayuki Nakamura; Juliette Gafni; Cameron Torcassi; Gabriele Schilling; Danielle Crippen; Jonathan D Wood; Akira Sawa; Nancy A Jenkins; Neal G Copeland; David R Borchelt; Christopher A Ross; Lisa M Ellerby
Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.
Neurobiology of disease 2006;21(2):381-91.
2005: Wanli Smith; Haibing Jiang; Zhong Pei; Yuji Tanaka; Hokuto Morita; Akira Sawa; Valina Dawson; Ted M Dawson; Christopher A Ross
Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity.
Human molecular genetics 2005;14(24):3801-11.
2005: Atsushi Kamiya; Ken-ichiro Kubo; Toshifumi Tomoda; Manabu Takaki; Richard Youn; Yuji Ozeki; Naoya Sawamura; Una Park; Chikako Kudo; Masako Okawa; Christopher A Ross; Mary E Hatten; Kazunori Nakajima; Akira Sawa
A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development.
Nature cell biology 2005;7(12):1167-78.
2005: Akira Sawa; Solomon H Snyder
Genetics. Two genes link two distinct psychoses.
Science (New York, N.Y.) 2005;310(5751):1128-9.
2005: Xuan Zhang; Mamoru Tochigi; Jun Ohashi; Kazuhisa Maeda; Tadafumi Kato; Yuji Okazaki; Nobumasa Kato; Katsushi Tokunaga; Akira Sawa; Tsukasa Sasaki
Association study of the DISC1/TRAX locus with schizophrenia in a Japanese population.
Schizophrenia research 2005;79(2-3):175-80.
2005: Akira Sawa; Eiichiro Nagata; Siobhan Sutcliffe; Pratima Dulloor; Matthew Cascio; Yuji Ozeki; Sophie Roy; Christopher A Ross; Solomon H Snyder
Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts.
Neurobiology of disease 2005;20(2):267-74.
2005: Ariel Lyons-Warren; J J Chang; Rishi Balkissoon; Atsushi Kamiya; M Garant; John Nurnberger; William A Scheftner; T Reich; Francis McMajon; John R Kelsoe; Elliot S Gershon; W Coryell; William Byerley; Wade H Berrettini; J. Raymond DePaulo; Melvin G McInnis; Akira Sawa
Evidence of association between bipolar disorder and Citron on chromosome 12q24.
Molecular psychiatry 2005;10(9):807-9.
2005: N A Sachs; Akira Sawa; Susan E Holmes; Christopher A Ross; Lynn E DeLisi; Russell L Margolis
A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder.
Molecular psychiatry 2005;10(8):758-64.
2005: Byoung-Il Bae; Hong Xu; Shuichi Igarashi; Masahiro Fujimuro; Nishant Agrawal; Yoichi Taya; S Diane Hayward; Timothy H Moran; Craig Montell; Christopher A Ross; Solomon H Snyder; Akira Sawa
p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease.
Neuron 2005;47(1):29-41.
2005: Makoto R Hara; Nishant Agrawal; Sangwon Kim; Matthew Cascio; Masahiro Fujimuro; Yuji Ozeki; Masaaki Takahashi; Jaime H Cheah; Stephanie Tankou; Lynda D Hester; Christopher D Ferris; S Diane Hayward; Solomon H Snyder; Akira Sawa
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding.
Nature cell biology 2005;7(7):665-74.
2005: Naoya Sawamura; Takako Sawamura-Yamamoto; Yuji Ozeki; Christopher A Ross; Akira Sawa
A form of DISC1 enriched in nucleus: altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(4):1187-92.
2004: Eiichiro Nagata; Akira Sawa; Christopher A Ross; Solomon H Snyder
Autophagosome-like vacuole formation in Huntington's disease lymphoblasts.
Neuroreport 2004;15(8):1325-8.
2004: Akira Sawa; Mikhail V Pletnikov; Atsushi Kamiya
Neuron-glia interactions clarify genetic-environmental links in mental illness.
Trends in neurosciences 2004;27(6):294-7.
2004: Yuji Ozeki; Masako Okawa; Akira Sawa
[DISC1 and schizophrenia].
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 2004;24(2):87-91.
2004: Hirohiko Kanai; Akira Sawa; Ren-Wu Chen; Peter Leeds; De-Maw Chuang
Valproic acid inhibits histone deacetylase activity and suppresses excitotoxicity-induced GAPDH nuclear accumulation and apoptotic death in neurons.
The pharmacogenomics journal 2004;4(5):336-44.
2004: T Tsutsumi; Susan E Holmes; Melvin G McInnis; Akira Sawa; Colleen Callahan; J. Raymond DePaulo; Christopher A Ross; Lynn E DeLisi; Russell L Margolis
Novel CAG/CTG repeat expansion mutations do not contribute to the genetic risk for most cases of bipolar disorder or schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004;124B(1):15-9.
2003: Akira Sawa; Atsushi Kamiya
Elucidating the pathogenesis of schizophrenia.
BMJ (Clinical research ed.) 2003;327(7416):632-3.
2003: Frederick C Nucifora; Lisa M Ellerby; Cheryl L Wellington; Jonathan D Wood; William Joseph Herring; Akira Sawa; Michael R Hayden; Valina Dawson; Ted M Dawson; Christopher A Ross
Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity.
The Journal of biological chemistry 2003;278(15):13047-55.
2003: Shuichi Igarashi; Hokuto Morita; Kyla M Bennett; Yuji Tanaka; Simone Engelender; Matthew F Peters; Jillian K Cooper; Jonathan D Wood; Akira Sawa; Christopher A Ross
Inducible PC12 cell model of Huntington's disease shows toxicity and decreased histone acetylation.
Neuroreport 2003;14(4):565-8.
2003: Yuji Ozeki; Toshifumi Tomoda; John Kleiderlein; Atsushi Kamiya; Lyuda Bord; Kumiko Fujii; Masako Okawa; Naoto Yamada; Mary E Hatten; Solomon H Snyder; Christopher A Ross; Akira Sawa
Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):289-94.
2003: Akira Sawa; Toshifumi Tomoda; Byoung-Il Bae
Mechanisms of neuronal cell death in Huntington's disease.
Cytogenetic and genome research 2003;100(1-4):287-95.
2003: Seth Blackshaw; M J L Eliasson; Akira Sawa; Crystal C Watkins; DK Krug; Amitabh Gupta; T Arai; Robert J Ferrante; Solomon H Snyder
Species, strain and developmental variations in hippocampal neuronal and endothelial nitric oxide synthase clarify discrepancies in nitric oxide-dependent synaptic plasticity.
Neuroscience 2003;119(4):979-90.
2003: Akira Sawa; Solomon H Snyder
Schizophrenia: neural mechanisms for novel therapies.
Molecular medicine (Cambridge, Mass.) 2003;9(1-2):3-9.
2002: Akira Sawa; Solomon H Snyder
Schizophrenia: diverse approaches to a complex disease.
Science (New York, N.Y.) 2002;296(5568):692-5.
2001: Hongbo R Luo; Adolfo Saiardi; Eiichiro Nagata; Keqiang Ye; H Yu; T S Jung; Xiaojiang Luo; S Jain; Akira Sawa; Solomon H Snyder
GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase.
Neuron 2001;31(3):439-51.
2001: Akira Sawa
Mechanisms for neuronal cell death and dysfunction in Huntington's disease: pathological cross-talk between the nucleus and the mitochondria?
Journal of molecular medicine (Berlin, Germany) 2001;79(7):375-81.
2001: Yuji Tanaka; Simone Engelender; S Igarashi; R K Rao; Tracy J Wanner; Rudolph E Tanzi; Akira Sawa; V L Dawson; Ted M Dawson; Christopher A Ross
Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis.
Human molecular genetics 2001;10(9):919-26.
2001: Adolfo Saiardi; Eiichiro Nagata; Hongbo R Luo; Akira Sawa; Xiaojiang Luo; Adele M Snowman; Solomon H Snyder
Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2306-11.
2001: Akira Sawa
Alteration of gene expression in Down's syndrome (DS) brains: its significance in neurodegeneration.
Journal of neural transmission. Supplementum 2001;(61):361-71.
2000: Masaaki Takahashi; Sylvain Dore; Christopher D Ferris; Taisuke Tomita; Akira Sawa; H Wolosker; David R Borchelt; Takeshi Iwatsubo; Seong-Hun Kim; Gopal Thinakaran; Sangram S Sisodia; Solomon H Snyder
Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease.
Neuron 2000;28(2):461-73.
2000: Ming Fang; Samie R Jaffrey; Akira Sawa; Keqiang Ye; Xiaojiang Luo; Solomon H Snyder
Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON.
Neuron 2000;28(1):183-93.
2000: Crystal C Watkins; Akira Sawa; Samie R Jaffrey; Seth Blackshaw; Roxanne K Barrow; Solomon H Snyder; Christopher D Ferris
Insulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathy.
The Journal of clinical investigation 2000;106(3):373-84.
2000: Seth Blackshaw; Akira Sawa; Alan H Sharp; Christopher A Ross; Solomon H Snyder; A A Khan
Type 3 inositol 1,4,5-trisphosphate receptor modulates cell death.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(10):1375-9.
2000: Sylvain Dore; Shozo Goto; Kenji Sampei; Seth Blackshaw; Lynda D Hester; Tatsuya Ingi; Akira Sawa; Richard J Traystman; Raymond C Koehler; Solomon H Snyder
Heme oxygenase-2 acts to prevent neuronal death in brain cultures and following transient cerebral ischemia.
Neuroscience 2000;99(4):587-92.
1999: Akira Sawa; GW Wiegand; J Cooper; Russell L Margolis; Alan H Sharp; Joseph F Lawler; J Timothy Greenamyre; Solomon H Snyder; Christopher A Ross
Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization.
Nature medicine 1999;5(10):1194-8.
1999: Daniel E Epner; Akira Sawa; John T Isaacs
Glyceraldehyde-3-phosphate dehydrogenase expression during apoptosis and proliferation of rat ventral prostate.
Biology of reproduction 1999;61(3):687-91.
1999: Christopher D Ferris; Samie R Jaffrey; Akira Sawa; Masaaki Takahashi; S D Brady; Roxanne K Barrow; S A Tysoe; H Wolosker; DE Barañano; Sylvain Dore; KD Poss; Solomon H Snyder
Haem oxygenase-1 prevents cell death by regulating cellular iron.
Nature cell biology 1999;1(3):152-7.
1999: Akira Sawa
Neuronal cell death in Down's syndrome.
Journal of neural transmission. Supplementum 1999;57():87-97.
1998: C Conrad; Naoji Amano; A Andreadis; Y Xia; K Namekataf; Fumitaka Oyama; K Ikeda; K Wakabayashi; H Takahashi; Leon J Thal; Robert Katzman; Deborah A Shackelford; M Matsushita; Eliezer Masliah; Akira Sawa
Differences in a dinucleotide repeat polymorphism in the tau gene between Caucasian and Japanese populations: implication for progressive supranuclear palsy.
Neuroscience letters 1998;250(2):135-7.
1997: M Honda; E Koga; T Ishikawa; T Kobayashi; Akira Sawa; Y Takahashi; Yutaka Honda
Alpha-delta sleep in a case with non-24 h sleep-wake syndrome: quantitative electroencephalogram analysis of alpha and delta band waves.
Psychiatry and clinical neurosciences 1997;51(6):387-92.
1997: Akira Sawa; A A Khan; Lynda D Hester; Solomon H Snyder
Glyceraldehyde-3-phosphate dehydrogenase: nuclear translocation participates in neuronal and nonneuronal cell death.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11669-74.
1997: Akira Sawa; Fumitaka Oyama; Nigel J Cairns; Naoji Amano; M Matsushita
Aberrant expression of bcl-2 gene family in Down's syndrome brains.
Brain research. Molecular brain research 1997;48(1):53-9.
1997: Akira Sawa; Naoji Amano; N Yamada; H Kajio; Saburo Yagishita; T Takahashi; M Oda; N Arai; K Ikeda; M Tadokoro; M Matsushita
Apolipoprotein E in progressive supranuclear palsy in Japan.
Molecular psychiatry 1997;2(4):341-2.
1994: Akira Sawa; Fumitaka Oyama; M Matsushita; Yasuo Ihara
Molecular diversity at the carboxyl terminus of human and rat tau.
Brain research. Molecular brain research 1994;27(1):111-7.
1992: Akira Sawa
[Psychiatric hospitals' viewpoint of rehabilitation of patients with mental diseases--their residential problems and development of group homes].
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 1992;94(11):1145-56.