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Tatsuya Sawamura

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Hidenori Arai; Yasuki Ito; Yoshihiro Kokubo; Asako Minagawa; Tomonori Okamura; Tatsuya Sawamura; Makoto Watanabe; Yoshihiro Miyamato
Small dense low-density lipoproteins cholesterol can predict incident cardiovascular disease in an urban Japanese cohort: the Suita study.
Kei Sato; Tatsuya Sawamura; Kenji Sunagawa; Shunsuke Katsuki; Tetsuya Matoba; Kaku Nakano; Kyoichi Osada; Kensuke Egashira
Dietary cholesterol oxidation products accelerate plaque destabilization and rupture associated with monocyte infiltration/activation via the MCP-1-CCR2 pathway in mouse brachiocephalic arteries: therapeutic effects of ezetimibe.
Masahiro Ishikawa; Hiromu Ito; Akemi Kakino; Takashi Kasahara; Noriaki Kume; Hirokazu Mitsuoka; Koichi Murata; Tatsuya Sawamura; Hideyuki Shibuya; Shimei Tanida; Tadashi Yasuda; Hiroyuki Yoshitomi; Miki Akiyoshi; Yoshiko Fujita; Takashi Nakamura
Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis.

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All Publications

2013: Hidenori Arai; Yasuki Ito; Yoshihiro Kokubo; Asako Minagawa; Tomonori Okamura; Tatsuya Sawamura; Makoto Watanabe; Yoshihiro Miyamato
Small dense low-density lipoproteins cholesterol can predict incident cardiovascular disease in an urban Japanese cohort: the Suita study.
Journal of atherosclerosis and thrombosis 2013;20(2):195-203.
2012: Kei Sato; Tatsuya Sawamura; Kenji Sunagawa; Shunsuke Katsuki; Tetsuya Matoba; Kaku Nakano; Kyoichi Osada; Kensuke Egashira
Dietary cholesterol oxidation products accelerate plaque destabilization and rupture associated with monocyte infiltration/activation via the MCP-1-CCR2 pathway in mouse brachiocephalic arteries: therapeutic effects of ezetimibe.
Journal of atherosclerosis and thrombosis 2012;19(11):986-98.
2012: Masahiro Ishikawa; Hiromu Ito; Akemi Kakino; Takashi Kasahara; Noriaki Kume; Hirokazu Mitsuoka; Koichi Murata; Tatsuya Sawamura; Hideyuki Shibuya; Shimei Tanida; Tadashi Yasuda; Hiroyuki Yoshitomi; Miki Akiyoshi; Yoshiko Fujita; Takashi Nakamura
Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis.
Arthritis and rheumatism 2012;64(4):1024-34.
2009: Yasuya Inomata; Mikiko Fukushima; Ryuhei Hara; Eri Takahashi; Megumi Honjo; Takahisa Koga; Takahiro Kawaji; Hiroo Satoh; Motohiro Takeya; Tatsuya Sawamura; Hidenobu Tanihara
Suppression of choroidal neovascularization in lectin-like oxidized low-density lipoprotein receptor type 1-deficient mice.
Investigative ophthalmology & visual science 2009;50(8):3970-6.
2004: Takumi Kakinuma; Tadashi Yasuda; Takefumi Nakagawa; Teruko Hiramitsu; Miki Akiyoshi; Masao Akagi; Tatsuya Sawamura; Takashi Nakamura
Lectin-like oxidized low-density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low-density lipoprotein in rheumatoid arthritis cartilage.
Arthritis and rheumatism 2004;50(11):3495-503.
2003: Megumi Honjo; Kayo Nakamura; Kenji Yamashiro; Junichi Kiryu; Hidenobu Tanihara; Leslie M McEvoy; Yoshihito Honda; Eugene C Butcher; Tomoh Masaki; Tatsuya Sawamura
Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1274-9.
2003: Kazuaki Kataoka; Koji Hasegawa; Tatsuya Sawamura; Masatoshi Fujita; Tetsuhiko Yanazume; Eri Iwai-Kanai; Teruhisa Kawamura; Taku Hirai; Toru Kita; Ryuji Nohara
LOX-1 pathway affects the extent of myocardial ischemia-reperfusion injury.
Biochemical and biophysical research communications 2003;300(3):656-60.
2002: Megumi Honjo; Hidenobu Tanihara; Kazuaki Nishijima; Junichi Kiryu; Yoshihito Honda; Beatrice Y J T Yue; Tatsuya Sawamura
Statin inhibits leukocyte-endothelial interaction and prevents neuronal death induced by ischemia-reperfusion injury in the rat retina.
Archives of ophthalmology 2002;120(12):1707-13.
2002: Takefumi Nakagawa; Tadashi Yasuda; Hajime Hoshikawa; Makoto Shimizu; Takumi Kakinuma; Mingyi Chen; Tomoh Masaki; Takashi Nakamura; Tatsuya Sawamura
LOX-1 expressed in cultured rat chondrocytes mediates oxidized LDL-induced cell death-possible role of dephosphorylation of Akt.
Biochemical and biophysical research communications 2002;299(1):91-7.
2002: Takefumi Nakagawa; Masao Akagi; Hajime Hoshikawa; Mingyi Chen; Tadashi Yasuda; Shogo Mukai; Kunitaka Ohsawa; Tomoh Masaki; Takashi Nakamura; Tatsuya Sawamura
Lectin-like oxidized low-density lipoprotein receptor 1 mediates leukocyte infiltration and articular cartilage destruction in rat zymosan-induced arthritis.
Arthritis and rheumatism 2002;46(9):2486-94.
2002: Megumi Honjo; Masaru Inatani; Noriaki Kido; Tatsuya Sawamura; Beatrice Y J T Yue; Yoshihito Honda; Hidenobu Tanihara
A myosin light chain kinase inhibitor, ML-9, lowers the intraocular pressure in rabbit eyes.
Experimental eye research 2002;75(2):135-42.
2001: Eri Iwai-Kanai; Koji Hasegawa; Tatsuya Sawamura; Masatoshi Fujita; Tetsuhiko Yanazume; Shinya Toyokuni; Souichi Adachi; Yasuki Kihara; Shigetake Sasayama
Activation of lectin-like oxidized low-density lipoprotein receptor-1 induces apoptosis in cultured neonatal rat cardiac myocytes.
Circulation 2001;104(24):2948-54.
2001: Takeshi Shimaoka; Noriaki Kume; Manabu Minami; Kazutaka Hayashida; Tatsuya Sawamura; Toru Kita; Shin Yonehara
Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) supports cell adhesion to fibronectin.
FEBS letters 2001;504(1-2):65-8.
2001: Megumi Honjo; Masaru Inatani; Noriaki Kido; Tatsuya Sawamura; Beatrice Y J T Yue; Yoshihito Honda; Hidenobu Tanihara
Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes.
Archives of ophthalmology 2001;119(8):1171-8.
2001: Takeshi Shimaoka; Noriaki Kume; Manabu Minami; Kazutaka Hayashida; Tatsuya Sawamura; Toru Kita; Shin Yonehara
LOX-1 supports adhesion of Gram-positive and Gram-negative bacteria.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(8):5108-14.
2001: Atsushi Iwakura; Masatoshi Fujita; Koji Hasegawa; Shinya Toyokuni; Tatsuya Sawamura; Ryuji Nohara; Shigetake Sasayama; Masashi Komeda
Pericardial fluid from patients with ischemic heart disease induces myocardial cell apoptotis via an oxidant stress-sensitive p38 mitogen-activated protein kinase pathway.
Journal of molecular and cellular cardiology 2001;33(3):419-30.
2001: Megumi Honjo; Hidenobu Tanihara; Masaru Inatani; Noriaki Kido; Tatsuya Sawamura; Beatrice Y J T Yue; Shuh Narumiya; Yoshihito Honda
Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility.
Investigative ophthalmology & visual science 2001;42(1):137-44.
2000: Makoto Araki; Koji Hasegawa; Eri Iwai-Kanai; Masatoshi Fujita; Tatsuya Sawamura; Tsuyoshi Kakita; Hiromichi Wada; Tatsuya Morimoto; Shigetake Sasayama
Endothelin-1 as a protective factor against beta-adrenergic agonist-induced apoptosis in cardiac myocytes.
Journal of the American College of Cardiology 2000;36(4):1411-8.
2000: T Yoneda; Masatoshi Fujita; Yasuki Kihara; Koji Hasegawa; Tatsuya Sawamura; Tomoko Tanaka; M Inanami; Ryuji Nohara; Shigetake Sasayama
Pericardial fluid from patients with ischemic heart disease accelerates the growth of human vascular smooth muscle cells.
Japanese circulation journal 2000;64(7):495-8.
2000: Manabu Minami; Noriaki Kume; Hiroharu Kataoka; M Morimoto; Kazutaka Hayashida; Tatsuya Sawamura; Tomoh Masaki; Toru Kita
Transforming growth factor-beta(1) increases the expression of lectin-like oxidized low-density lipoprotein receptor-1.
Biochemical and biophysical research communications 2000;272(2):357-61.
2000: Atsushi Iwakura; Masatoshi Fujita; Koji Hasegawa; Tatsuya Sawamura; Ryuji Nohara; Shigetake Sasayama; Masashi Komeda
Pericardial fluid from patients with unstable angina induces vascular endothelial cell apoptosis.
Journal of the American College of Cardiology 2000;35(7):1785-90.
2000: Hiroharu Kataoka; Noriaki Kume; Manabu Minami; H Moriwaki; Tatsuya Sawamura; Tomoh Masaki; Toru Kita
Expression of lectin-like oxidized LDL receptor-1 in human atherosclerotic lesions.
Annals of the New York Academy of Sciences 2000;902():328-35.
2000: Noriaki Kume; H Moriwaki; Hiroharu Kataoka; Manabu Minami; Takatoshi Murase; Tatsuya Sawamura; Tomoh Masaki; Toru Kita
Inducible expression of LOX-1, a novel receptor for oxidized LDL, in macrophages and vascular smooth muscle cells.
Annals of the New York Academy of Sciences 2000;902():323-7.
2000: Hiroharu Kataoka; Noriaki Kume; Shoichi Miyamoto; Manabu Minami; Takatoshi Murase; Tatsuya Sawamura; Tomoh Masaki; Nobuo Hashimoto; Toru Kita
Biosynthesis and post-translational processing of lectin-like oxidized low density lipoprotein receptor-1 (LOX-1). N-linked glycosylation affects cell-surface expression and ligand binding.
The Journal of biological chemistry 2000;275(9):6573-9.
2000: Takatoshi Murase; Noriaki Kume; Hiroharu Kataoka; Manabu Minami; Tatsuya Sawamura; Tomoh Masaki; Toru Kita
Identification of soluble forms of lectin-like oxidized LDL receptor-1.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(3):715-20.
1999: Tomoki Aoyama; Hiroshi Fujiwara; Tomoh Masaki; Tatsuya Sawamura
Induction of lectin-like oxidized LDL receptor by oxidized LDL and lysophosphatidylcholine in cultured endothelial cells.
Journal of molecular and cellular cardiology 1999;31(12):2101-14.
1999: Hiroharu Kataoka; Noriaki Kume; Shoichi Miyamoto; Manabu Minami; H Moriwaki; Takatoshi Murase; Tatsuya Sawamura; Tomoh Masaki; Nobuo Hashimoto; Toru Kita
Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions.
Circulation 1999;99(24):3110-7.
1999: Tomoki Aoyama; Tatsuya Sawamura; Y Furutani; R Matsuoka; Masasuke Yoshida; Hiroshi Fujiwara; Tomoh Masaki
Structure and chromosomal assignment of the human lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1) gene.
The Biochemical journal 1999;339 ( Pt 1)():177-84.
1999: S Kaburagi; Koji Hasegawa; Tatsuya Morimoto; Makoto Araki; Tatsuya Sawamura; Tomoh Masaki; Shigetake Sasayama
The role of endothelin-converting enzyme-1 in the development of alpha1-adrenergic-stimulated hypertrophy in cultured neonatal rat cardiac myocytes.
Circulation 1999;99(2):292-8.
1998: K Kikuta; Tatsuya Sawamura; S Miwa; Nobuo Hashimoto; Tomoh Masaki
High-affinity arginine transport of bovine aortic endothelial cells is impaired by lysophosphatidylcholine.
Circulation research 1998;83(11):1088-96.
1998: H Moriwaki; Noriaki Kume; Hiroharu Kataoka; Takatoshi Murase; Eiichiro Nishi; Tatsuya Sawamura; Tomoh Masaki; Toru Kita
Expression of lectin-like oxidized low density lipoprotein receptor-1 in human and murine macrophages: upregulated expression by TNF-alpha.
FEBS letters 1998;440(1-2):29-32.
1998: H Moriwaki; Noriaki Kume; Tatsuya Sawamura; Tomoki Aoyama; Hajime Hoshikawa; Hirofumi Ochi; Eiichiro Nishi; Tomoh Masaki; Toru Kita
Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(10):1541-7.
1998: Takatoshi Murase; Noriaki Kume; R Korenaga; J Ando; Tatsuya Sawamura; Tomoh Masaki; Toru Kita
Fluid shear stress transcriptionally induces lectin-like oxidized LDL receptor-1 in vascular endothelial cells.
Circulation research 1998;83(3):328-33.
1998: Noriaki Kume; Takatoshi Murase; H Moriwaki; Tomoki Aoyama; Tatsuya Sawamura; Tomoh Masaki; Toru Kita
Inducible expression of lectin-like oxidized LDL receptor-1 in vascular endothelial cells.
Circulation research 1998;83(3):322-7.
1998: K Oka; Tatsuya Sawamura; K Kikuta; Shigekazu Itokawa; Noriaki Kume; Toru Kita; Tomoh Masaki
Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9535-40.
1998: H Hasegawa; K Hiki; Tatsuya Sawamura; T Aoyama; Y Okamoto; Soichi Miwa; Shun Shimohama; J Kimura; Tomoh Masaki
Purification of a novel endothelin-converting enzyme specific for big endothelin-3.
FEBS letters 1998;428(3):304-8.
1998: Hajime Hoshikawa; Tatsuya Sawamura; M Kakutani; Tomoki Aoyama; Tetsuya Nakamura; Tomoh Masaki
High affinity binding of oxidized LDL to mouse lectin-like oxidized LDL receptor (LOX-1).
Biochemical and biophysical research communications 1998;245(3):841-6.
1997: H Hosokawa; Tatsuya Sawamura; Shigeo Kobayashi; Haruaki Ninomiya; Soichi Miwa; Tomoh Masaki
Cloning and characterization of a brain-specific cationic amino acid transporter.
The Journal of biological chemistry 1997;272(13):8717-22.
1997: Tatsuya Sawamura; Noriaki Kume; Tomoki Aoyama; H Moriwaki; Hajime Hoshikawa; Y Aiba; Tetsuaki Tanaka; S Miwa; Y Katsura; Toru Kita; Tomoh Masaki
An endothelial receptor for oxidized low-density lipoprotein.
Nature 1997;386(6620):73-7.
1997: T Kido; Tatsuya Sawamura; Hajime Hoshikawa; Pedro D'Orléans-Juste; Jean-Bernard Denault; Richard Leduc; J Kimura; Tomoh Masaki
Processing of proendothelin-1 at the C-terminus of big endothelin-1 is essential for proteolysis by endothelin-converting enzyme-1 in vivo.
European journal of biochemistry / FEBS 1997;244(2):520-6.
1996: Rumiko Matsuoka; Tatsuya Sawamura; K Yamada; M Yoshida; Yoshiyuki Furutani; T Ikura; T Shiraki; Hajime Hoshikawa; K Shimada; K Tanzawa; Tomoh Masaki
Human endothelin converting enzyme gene (ECE1) mapped to chromosomal region 1p36.1.
Cytogenetics and cell genetics 1996;72(4):322-4.
1995: Jean-Bernard Denault; A Claing; Pedro D'Orléans-Juste; Tatsuya Sawamura; T Kido; Tomoh Masaki; Richard Leduc
Processing of proendothelin-1 by human furin convertase.
FEBS letters 1995;362(3):276-80.
1994: T Ikura; Tatsuya Sawamura; T Shiraki; H Hosokawa; T Kido; Hajime Hoshikawa; K Shimada; K Tanzawa; Shigeo Kobayashi; Soichi Miwa
cDNA cloning and expression of bovine endothelin converting enzyme.
Biochemical and biophysical research communications 1994;203(3):1417-22.
1994: T Shiraki; Tatsuya Sawamura; T Ikura; Shigeo Kobayashi; Soichi Miwa; Tomoh Masaki
Genetic transfer of endothelin converting enzyme activity to CHO-K1 cells: detection of positive cells by reverse hemolytic plaque assay.
FEBS letters 1994;351(2):197-200.
1993: A Sakamoto; Masashi Yanagisawa; Tatsuya Sawamura; T Enoki; T Ohtani; T Sakurai; Kazuwa Nakao; T Toyo-oka; Tomoh Masaki
Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists.
The Journal of biological chemistry 1993;268(12):8547-53.
1993: Tatsuya Sawamura; O Shinmi; N Kishi; Y Sugita; Masashi Yanagisawa; Katsutoshi Goto; Tomoh Masaki; S Kimura
Characterization of phosphoramidon-sensitive metalloproteinases with endothelin-converting enzyme activity in porcine lung membrane.
Biochimica et biophysica acta 1993;1161(2-3):295-302.
1992: Tatsuya Sawamura; Tomoh Masaki
[Biosynthetic pathway of endothelin].
Nihon rinsho. Japanese journal of clinical medicine 1992;50 Suppl():54-61.
1991: Tatsuya Sawamura; Y Kasuya; Y Matsushita; N Suzuki; O Shinmi; N Kishi; Y Sugita; Masashi Yanagisawa; Katsutoshi Goto; Tomoh Masaki
Phosphoramidon inhibits the intracellular conversion of big endothelin-1 to endothelin-1 in cultured endothelial cells.
Biochemical and biophysical research communications 1991;174(2):779-84.
1990: Tatsuya Sawamura; O Shinmi; N Kishi; Y Sugita; Masashi Yanagisawa; Katsutoshi Goto; Tomoh Masaki; S Kimura
Analysis of big endothelin-1 digestion by cathepsin D.
Biochemical and biophysical research communications 1990;172(2):883-9.
1990: Tatsuya Sawamura; S Kimura; Tomoh Masaki
[Endothelin].
No shinkei geka. Neurological surgery 1990;18(9):797-806.
1990: Tatsuya Sawamura; S Kimura; O Shinmi; Y Sugita; M Kobayashi; Y Mitsui; Masashi Yanagisawa; Katsutoshi Goto; Tomoh Masaki
Characterization of endothelin converting enzyme activities in soluble fraction of bovine cultured endothelial cells.
Biochemical and biophysical research communications 1990;169(3):1138-44.
1990: Tatsuya Sawamura; S Kimura; O Shinmi; Y Sugita; Masashi Yanagisawa; Katsutoshi Goto; Tomoh Masaki
Purification and characterization of putative endothelin converting enzyme in bovine adrenal medulla: evidence for a cathepsin D-like enzyme.
Biochemical and biophysical research communications 1990;168(3):1230-6.
1989: O Shinmi; S Kimura; Tatsuya Sawamura; Y Sugita; T Yoshizawa; Y Uchiyama; Masashi Yanagisawa; Katsutoshi Goto; Tomoh Masaki; I Kanazawa
Endothelin-3 is a novel neuropeptide: isolation and sequence determination of endothelin-1 and endothelin-3 in porcine brain.
Biochemical and biophysical research communications 1989;164(1):587-93.
1989: Tatsuya Sawamura; S Kimura; O Shinmi; Y Sugita; Masashi Yanagisawa; Tomoh Masaki
Analysis of endothelin related peptides in culture supernatant of porcine aortic endothelial cells: evidence for biosynthetic pathway of endothelin-1.
Biochemical and biophysical research communications 1989;162(3):1287-94.
1989: O Shinmi; S Kimura; T Yoshizawa; Tatsuya Sawamura; Y Uchiyama; Y Sugita; I Kanazawa; Masashi Yanagisawa; Katsutoshi Goto; Tomoh Masaki
Presence of endothelin-1 in porcine spinal cord: isolation and sequence determination.
Biochemical and biophysical research communications 1989;162(1):340-6.
1989: S Kimura; Y Kasuya; Tatsuya Sawamura; O Shinimi; Y Sugita; Masashi Yanagisawa; Katsutoshi Goto; Tomoh Masaki
Conversion of big endothelin-1 to 21-residue endothelin-1 is essential for expression of full vasoconstrictor activity: structure-activity relationships of big endothelin-1.
Journal of cardiovascular pharmacology 1989;13 Suppl 5():S5-7; discussion S18.
1988: S Kimura; Y Kasuya; Tatsuya Sawamura; O Shinmi; Y Sugita; M Yanagisawa; K Goto; Tomoh Masaki
Structure-activity relationships of endothelin: importance of the C-terminal moiety.
Biochemical and biophysical research communications 1988;156(3):1182-6.