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Stephen Sawcer

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Maria Ban; Stacy J Caillier; Elisabeth Gulowsen Celius; Hanne F Harbo; Stephen L Hauser; Inger-Lise Mero; Kjell-Morten Myhr; Jorge Oksenberg; Stephen Sawcer; Oivind Torkildsen; Jan Aarseth; Alastair Compston
No evidence of association between mutant alleles of the CYP27B1 gene and multiple sclerosis.
Azza Ismail; Janine Kirby; James Lowe; Christopher J McDermott; Antonio Milano; Sian Price; Stephen Sawcer; Ian Scott; Basil Sharrack; D Alastair S Compston; Cris S Constantinescu; Johnathan Cooper-Knock; Emily Goodall; J Robin Highley; Stephen J Walters; Pamela J Shaw
Concurrence of multiple sclerosis and amyotrophic lateral sclerosis in patients with hexanucleotide repeat expansions of C9ORF72.
Stephen Sawcer; James Wason
Risk in complex genetics: "all models are wrong but some are useful".

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All Publications

2013: Maria Ban; Stacy J Caillier; Elisabeth Gulowsen Celius; Hanne F Harbo; Stephen L Hauser; Inger-Lise Mero; Kjell-Morten Myhr; Jorge Oksenberg; Stephen Sawcer; Oivind Torkildsen; Jan Aarseth; Alastair Compston
No evidence of association between mutant alleles of the CYP27B1 gene and multiple sclerosis.
Annals of neurology 2013;73(3):430-2.
2013: Azza Ismail; Janine Kirby; James Lowe; Christopher J McDermott; Antonio Milano; Sian Price; Stephen Sawcer; Ian Scott; Basil Sharrack; D Alastair S Compston; Cris S Constantinescu; Johnathan Cooper-Knock; Emily Goodall; J Robin Highley; Stephen J Walters; Pamela J Shaw
Concurrence of multiple sclerosis and amyotrophic lateral sclerosis in patients with hexanucleotide repeat expansions of C9ORF72.
Journal of neurology, neurosurgery, and psychiatry 2013;84(1):79-87.
2012: Stephen Sawcer; James Wason
Risk in complex genetics: "all models are wrong but some are useful".
Annals of neurology 2012;72(4):502-9.
2011: Stephen Sawcer
The major cause of multiple sclerosis is environmental: genetics has a minor role--no.
Multiple sclerosis (Houndmills, Basingstoke, England) 2011;17(10):1174-5.
2011: Rebecca L Zuvich; Lisa F Barcellos; Ashley H Beecham; William S Bush; Alastair Compston; Philip L De Jager; David A Hafler; Stephen L Hauser; Adrian J Ivinson; Jacob McCauley; Douglas P Mortlock; Margaret Pericak-Vance; Stephen Sawcer; Jonathan L Haines
Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex.
Human molecular genetics 2011;20(17):3517-24.
2011: Paul Bentley; Omar Malik; Richard Nicholas; Stephen Sawcer; Maria Ban; Tao Wang; Pankaj Sharma
CADASIL with cord involvement associated with a novel and atypical NOTCH3 mutation.
Journal of neurology, neurosurgery, and psychiatry 2011;82(8):855-60.
2011: I-L Mero; M Ban; C Smestad; Elisabeth Gulowsen Celius; H Sæther; H Saeedi; Marte K Viken; B Skinningsrud; DAG UNDLIEN; Jan H Aarseth; Kjell-Morten Myhr; S Granum; Anne Spurkland; Stephen Sawcer; Alastair Compston; Benedicte Lie; Å R Lorentzen; Hanne F Harbo
Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus.
Genes and immunity 2011;12(3):191-8.
2011: Anu Kemppinen; Stephen Sawcer; Alastair Compston
Genome-wide association studies in multiple sclerosis: lessons and future prospects.
Briefings in functional genomics 2011;10(2):61-70.
2011: Stephen Sawcer; Garrett Hellenthal
The major histocompatibility complex and multiple sclerosis: a smoking gun?
Brain : a journal of neurology 2011;134(Pt 3):638-40.
2011: Lekha Pandit; Maria Ban; Stephen Sawcer; Bhim Singhal; Shyam Nair; Kurupath Radhakrishnan; Rajesh Shetty; Z Misri; Suresh Hegde; Irruvathur Gopalakrishna Bhat
Evaluation of the established non-MHC multiple sclerosis loci in an Indian population.
Multiple sclerosis (Houndmills, Basingstoke, England) 2011;17(2):139-43.
2010: Maria Ban; Jacob McCauley; R Zuvich; A Baker; L Bergamaschi; M Cox; A Kemppinen; S D'Alfonso; F R Guerini; J Lechner-Scott; Frank Dudbridge; J Wason; N P Robertson; P L De Jager; D A Hafler; Lisa F Barcellos; A J Ivinson; D Sexton; J R Oksenberg; S L Hauser; Margaret Pericak-Vance; J Haines; Alastair Compston; Stephen Sawcer
A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis.
Genes and immunity 2010;11(8):660-4.
2010: Farren B S Briggs; Selena Bartlett; Benjamin A Goldstein; Joanne Wang; Jacob McCauley; Rebecca L Zuvich; Philip L De Jager; John D Rioux; Adrian J Ivinson; Alastair Compston; David A Hafler; Stephen L Hauser; Jorge R Oksenberg; Stephen Sawcer; Margaret Pericak-Vance; Jonathan L Haines; Lisa F Barcellos
Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals.
Human molecular genetics 2010;19(21):4286-95.
2010: Misuzu Saiki; Amie Baker; Caroline H Williams-Gray; Thomas Foltynie; Reyna S Goodman; Craig J Taylor; D A S Compston; Roger A Barker; Stephen Sawcer; An Goris
Association of the human leucocyte antigen region with susceptibility to Parkinson's disease.
Journal of neurology, neurosurgery, and psychiatry 2010;81(8):890-1.
2010: Farren B S Briggs; Benjamin A Goldstein; Jacob McCauley; Rebecca L Zuvich; Philip L De Jager; John D Rioux; Adrian J Ivinson; Alastair Compston; David A Hafler; Stephen L Hauser; Jorge R Oksenberg; Stephen Sawcer; Margaret Pericak-Vance; Jonathan L Haines; Lisa F Barcellos
Variation within DNA repair pathway genes and risk of multiple sclerosis.
American journal of epidemiology 2010;172(2):217-24.
2010: Stephen Sawcer
Bayes factors in complex genetics.
European journal of human genetics : EJHG 2010;18(7):746-50.
2010: Koon Lee; Stephen Sawcer
Detecting genes in complex disease: does phenotype accuracy limit the horizon?
Trends in genetics : TIG 2010;26(6):241-2; author reply 242-3.
2010: Paola G Bronson; Stacy J Caillier; Patricia P Ramsay; Jacob McCauley; Rebecca L Zuvich; Philip L De Jager; John D Rioux; Adrian J Ivinson; Alastair Compston; David A Hafler; Stephen Sawcer; Margaret Pericak-Vance; Jonathan L Haines; Stephen L Hauser; Jorge R Oksenberg; Lisa F Barcellos
CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis.
Human molecular genetics 2010;19(11):2331-40.
2010: Laura Bergamaschi; Maria Ban; Maurizio A Leone; Stephen Sawcer; Sandra D'Alfonso
No evidence of association of the rare nsSNP rs35667974 in IFIH1 with multiple sclerosis.
Journal of neuroimmunology 2010;221(1-2):112-4.
2010: William S Bush; Stephen Sawcer; Philip L de Jager; Jorge R Oksenberg; Jacob McCauley; Margaret Pericak-Vance; Jonathan L Haines
Evidence for polygenic susceptibility to multiple sclerosis--the shape of things to come.
American journal of human genetics 2010;86(4):621-5.
2010: Rebecca L Zuvich; Jacob McCauley; Jorge R Oksenberg; Stephen Sawcer; Philip L De Jager; Cristin Aubin; Anne H Cross; Laura Piccio; Neelum T Aggarwal; Denis Evans; David A Hafler; Alastair Compston; Stephen L Hauser; Margaret Pericak-Vance; Jonathan L Haines
Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility.
Human genetics 2010;127(5):525-35.
2010: Bruce A C Cree; John D Rioux; Jacob McCauley; Pierre-Antoine Gourraud; Philippe Goyette; Joseph McElroy; Philip De Jager; Adam Santaniello; Timothy J Vyse; Peter K Gregersen; Daniel Mirel; David A Hafler; Jonathan L Haines; Margaret Pericak-Vance; Alastair Compston; Stephen Sawcer; Jorge R Oksenberg; Stephen L Hauser
A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.
PloS one 2010;5(6):e11296.
2010: Stephen Sawcer; Maria Ban; James Wason; Frank Dudbridge
What role for genetics in the prediction of multiple sclerosis?
Annals of neurology 2010;67(1):3-10.
2009: Caroline H Williams-Gray; Jonathan R Evans; An Goris; Thomas Foltynie; Maria Ban; Trevor W Robbins; Carol Brayne; Bhaskar S Kolachana; Daniel R Weinberger; Stephen Sawcer; Roger A Barker
The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort.
Brain : a journal of neurology 2009;132(Pt 11):2958-69.
2009: Stephen Sawcer
The genetic aspects of multiple sclerosis.
Annals of Indian Academy of Neurology 2009;12(4):206-14.
2009: Joanne L Jones; Chia-Ling Phuah; Amanda L Cox; Sara A Thompson; Maria Ban; Jacqueline Shawcross; Amie Walton; Stephen Sawcer; Alastair Compston; Alasdair J Coles
IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H).
The Journal of clinical investigation 2009;119(7):2052-61.
2009: Caroline H Williams-Gray; An Goris; Misuzu Saiki; Thomas Foltynie; D A S Compston; Stephen Sawcer; Roger A Barker
Apolipoprotein E genotype as a risk factor for susceptibility to and dementia in Parkinson's disease.
Journal of neurology 2009;256(3):493-8.
2009: Caroline Williams-Gray; An Goris; Thomas Foltynie; Alastair Compston; Stephen Sawcer; Roger A Barker
No evidence for association between an MAOA functional polymorphism and susceptibility to Parkinson's disease.
Journal of neurology 2009;256(1):132-3.
2009: Lisa M Maier; Christopher E Lowe; Jason Cooper; Kate Downes; David E Anderson; Christopher Severson; Pamela M Clark; Brian Healy; Neil Walker; Cristin Aubin; Jorge R Oksenberg; Stephen L Hauser; Alistair Compston; Stephen Sawcer; Philip De Jager; Linda S Wicker; John A Todd; David A Hafler
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.
PLoS genetics 2009;5(1):e1000322.
2008: A Goris; A Walton; M Ban; Bruno Dubois; Alastair Compston; Stephen Sawcer
A Taqman assay for high-throughput genotyping of the multiple sclerosis-associated HLA-DRB1*1501 allele.
Tissue antigens 2008;72(4):401-3.
2008: Lisa F Barcellos; P P Ramsay; Stacy J Caillier; Stephen Sawcer; Jonathan L Haines; Silke Schmidt; Margaret Pericak-Vance; D A S Compston; P Gabatto; Stephen L Hauser; Jorge R Oksenberg
Genetic variation in nitric oxide synthase 2A (NOS2A) and risk for multiple sclerosis.
Genes and immunity 2008;9(6):493-500.
2008: Jorge R Oksenberg; Sergio E Baranzini; Stephen Sawcer; Stephen L Hauser
The genetics of multiple sclerosis: SNPs to pathways to pathogenesis.
Nature reviews. Genetics 2008;9(7):516-26.
2008: David Moyes; An Goris; Maria Ban; Alistair Compston; David J Griffiths; Stephen Sawcer; Patrick J W Venables
HERV-K113 is not associated with multiple sclerosis in a large family-based study.
AIDS research and human retroviruses 2008;24(3):363-5.
2008: Maria Ban; Joanna Elson; Amie Walton; Douglas Turnbull; Alastair Compston; Patrick Chinnery; Stephen Sawcer
Investigation of the role of mitochondrial DNA in multiple sclerosis susceptibility.
PloS one 2008;3(8):e2891.
2008: Roger HORTON; Richard Gibson; Penny Coggill; Marcos M Miretti; Richard J N Allcock; Jeff Almeida; Simon Forbes; James G R Gilbert; Karen Halls; Jennifer L Harrow; Elizabeth Hart; Kevin L Howe; David K Jackson; Sophie Palmer; Anne N Roberts; Sarah Sims; Charles Stewart; James A Traherne; Steve Trevanion; Laurens G Wilming; Jane Rogers; Pieter J de Jong; John Elliott; Stephen Sawcer; John A Todd; John Trowsdale; Stephan Beck
Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project.
Immunogenetics 2008;60(1):1-18.
2007: Simon G Gregory; Silke Schmidt; Puneet Seth; Jorge R Oksenberg; John Hart; Angela Prokop; Stacy J Caillier; Maria Ban; An Goris; Lisa F Barcellos; Robin R Lincoln; Jacob McCauley; Stephen Sawcer; D A S Compston; Benedicte Dubois; Stephen L Hauser; Mariano A Garcia-Blanco; Margaret Pericak-Vance; Jonathan L Haines
Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis.
Nature genetics 2007;39(9):1083-91.
2007: David A Hafler; Alastair Compston; Stephen Sawcer; Eric S Lander; Mark J Daly; Philip De Jager; Paul I W de Bakker; Stacey B Gabriel; Daniel B Mirel; Adrian J Ivinson; Margaret Pericak-Vance; Simon G Gregory; John D Rioux; Jacob McCauley; Jonathan L Haines; Lisa F Barcellos; Bruce A C Cree; Jorge R Oksenberg; Stephen L Hauser
Risk alleles for multiple sclerosis identified by a genomewide study.
The New England journal of medicine 2007;357(9):851-62.
2007: An Goris; Caroline H Williams-Gray; Graeme R Clark; Thomas Foltynie; Simon J G Lewis; Joanne Brown; Maria Ban; Maria Grazia Spillantini; Alastair Compston; David J Burn; Patrick F Chinnery; Roger A Barker; Stephen Sawcer
Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease.
Annals of neurology 2007;62(2):145-53.
2007: An Goris; Caroline H Williams-Gray; Thomas Foltynie; Joanne Brown; Mel Maranian; Amie Walton; D A S Compston; Roger A Barker; Stephen Sawcer
Investigation of TGFB2 as a candidate gene in multiple sclerosis and Parkinson's disease.
Journal of neurology 2007;254(7):846-8.
2007: Maria Ban; Amie Walton; An Goris; Julia Gray; Alastair Compston; Stephen Sawcer
Polymorphisms in the neuromyelitis optica auto-antigen AQP4 and susceptibility to multiple sclerosis.
Journal of neurology 2007;254(3):398-9.
2007: Tai Wai Yeo; Philip De Jager; Simon G Gregory; Lisa F Barcellos; Amie Walton; An Goris; Chiara Fenoglio; Maria Ban; Craig J Taylor; Reyna S Goodman; Emily Walsh; Cara S Wolfish; Roger HORTON; James A Traherne; Stephan Beck; John Trowsdale; Stacy J Caillier; Adrian J Ivinson; Todd Green; Susan Pobywajlo; Eric S Lander; Margaret Pericak-Vance; Jonathan L Haines; Mark J Daly; Jorge R Oksenberg; Stephen L Hauser; Alastair Compston; David A Hafler; John D Rioux; Stephen Sawcer
A second major histocompatibility complex susceptibility locus for multiple sclerosis.
Annals of neurology 2007;61(3):228-36.
2006: An Goris; Tai Wai Yeo; Mel Maranian; Amie Walton; M Ban; Julia Gray; Alastair Compston; Stephen Sawcer
Novel Olig 1-coding variants and susceptibility to multiple sclerosis.
Journal of neurology, neurosurgery, and psychiatry 2006;77(11):1296-7.
2006: An Goris; Mel Maranian; Amie Walton; Tai Wai Yeo; Maria Ban; Julia Gray; Alastair Compston; Stephen Sawcer
No evidence for association of a European-specific chromosome 17 inversion with multiple sclerosis.
European journal of human genetics : EJHG 2006;14(10):1064.
2006: Lisa F Barcellos; Stephen Sawcer; Patricia P Ramsay; Sergio E Baranzini; Glenys Thomson; Farren Briggs; Bruce C A Cree; Ann B Begovich; Pablo Villoslada; Xavier Montalban; Antonio Uccelli; Giovanni Savettieri; Robin R Lincoln; Carolyn DeLoa; Jonathan L Haines; Margaret Pericak-Vance; Alastair Compston; Stephen L Hauser; Jorge R Oksenberg
Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis.
Human molecular genetics 2006;15(18):2813-24.
2006: Hanne F Harbo; Per O Ekstrøm; Aslaug R Lorentzen; Vibeke Sundvold-Gjerstad; Elisabeth Gulowsen Celius; Stephen Sawcer; Anne Spurkland
Coding region polymorphisms in T cell signal transduction genes. Prevalence and association to development of multiple sclerosis.
Journal of neuroimmunology 2006;177(1-2):40-5.
2006: Silke Schmidt; Margaret Pericak-Vance; Stephen Sawcer; Lisa F Barcellos; J Hart; J Sims; A M Prokop; J van der Walt; Cari DeLoa; Robin R Lincoln; Jorge R Oksenberg; Alastair Compston; Stephen L Hauser; Jonathan L Haines; Simon G Gregory
Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis.
Genes and immunity 2006;7(5):384-92.
2006: Stephen Sawcer
A new era in the genetic analysis of multiple sclerosis.
Current opinion in neurology 2006;19(3):237-41.
2006: Philip De Jager; R Graham; Lisa Farwell; Stephen Sawcer; A Richardson; timothy wayne behrens; Alastair Compston; David A Hafler; Juha Kere; Timothy J Vyse; John D Rioux
The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus.
Genes and immunity 2006;7(4):327-34.
2006: An Goris; Mel Maranian; Amie Walton; Tai Wai Yeo; Maria Ban; Julia Gray; Bénédicte Dubois; Alastair Compston; Stephen Sawcer
CD24 Ala/Val polymorphism and multiple sclerosis.
Journal of neuroimmunology 2006;175(1-2):200-2.
2006: Caroline H Williams-Gray; An Goris; Thomas Foltynie; Joanne Brown; Mel Maranian; Amie Walton; D A S Compston; Stephen Sawcer; Roger A Barker
Prevalence of the LRRK2 G2019S mutation in a UK community based idiopathic Parkinson's disease cohort.
Journal of neurology, neurosurgery, and psychiatry 2006;77(5):665-7.
2006: Caroline H Williams-Gray; An Goris; Thomas Foltynie; Joanne Brown; Mel Maranian; Amie Walton; D A S Compston; Stephen Sawcer; Roger A Barker
No alterations in alpha-synuclein gene dosage observed in sporadic Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2006;21(5):731-2.
2006: Amy Jayne McKnight; A Peter Maxwell; Stephen Sawcer; Alastair Compston; Efrosini Setakis; Chris C Patterson; Hugh R Brady; David A Savage
A genome-wide DNA microsatellite association screen to identify chromosomal regions harboring candidate genes in diabetic nephropathy.
Journal of the American Society of Nephrology : JASN 2006;17(3):831-6.
2006: Philip De Jager; Stephen Sawcer; Alicja Waliszewska; Lisa Farwell; Gary Wild; Albert Cohen; Diane Langelier; Alain Bitton; Alastair Compston; David A Hafler; John D Rioux
Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis.
European journal of human genetics : EJHG 2006;14(3):317-21.
2006: Stephen Sawcer; Alastair Compston
Multiple sclerosis: light at the end of the tunnel.
European journal of human genetics : EJHG 2006;14(3):257-8.
2006: Chiara Fenoglio; Daniela Galimberti; Maria Ban; Mel Maranian; Diego Scalabrini; Eliana Venturelli; Laura Piccio; Milena De Riz; Tai Wai Yeo; An Goris; Julia Gray; Nereo Bresolin; Elio Scarpini; Alastair Compston; Stephen Sawcer
SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis.
Neuroscience letters 2006;394(2):92-6.
2006: Richard Roxburgh; Stephen Sawcer; Mel Maranian; Shaun Seaman; Anke Hensiek; Taiwai Yeo; Jackie Deans; Alastair Compston
No evidence of a significant role for CTLA-4 in multiple sclerosis.
Journal of neuroimmunology 2006;171(1-2):193-7.
2006: James A Traherne; Roger HORTON; Anne N Roberts; Marcos M Miretti; Matthew E Hurles; Charles Stewart; Jennifer L Ashurst; Alexey Atrazhev; Penny Coggill; Sophie Palmer; Jeff Almeida; Sarah Sims; Laurens G Wilming; Jane Rogers; Pieter J de Jong; Mary Carrington; John Elliott; Stephen Sawcer; John A Todd; John Trowsdale; Stephan Beck
Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history.
PLoS genetics 2006;2(1):e9.
2006: James A Traherne; Lisa F Barcellos; Stephen Sawcer; Alastair Compston; Patricia P Ramsay; Stephen L Hauser; Jorge R Oksenberg; John Trowsdale
Association of the truncating splice site mutation in BTNL2 with multiple sclerosis is secondary to HLA-DRB1*15.
Human molecular genetics 2006;15(1):155-61.
2005: Barbara Borroni; Despina Yancopoulou; Miho Tsutsui; Alessandro Padovani; Stephen Sawcer; John R Hodges; Maria Grazia Spillantini
Association between tau H2 haplotype and age at onset in frontotemporal dementia.
Archives of neurology 2005;62(9):1419-22.
2005: David Moyes; Alex Martin; Stephen Sawcer; Nigel Temperton; Jane Worthington; David J Griffiths; Patrick J W Venables
The distribution of the endogenous retroviruses HERV-K113 and HERV-K115 in health and disease.
Genomics 2005;86(3):337-41.
2005: Maria Ban; Mel Maranian; Tai Wai Yeo; Julia Gray; Alastair Compston; Stephen Sawcer
Ultraconserved regions in multiple sclerosis.
European journal of human genetics : EJHG 2005;13(9):998-9.
2005: Maria Ban; Mel Maranian; Tai Wai Yeo; Julia Gray; Alastair Compston; Stephen Sawcer
Cis acting expression loci in multiple sclerosis.
Journal of neuroimmunology 2005;162(1-2):3-4.
2005: Maria Ban; Mel Maranian; Tai Wai Yeo; Julia Gray; Alastair Compston; Stephen Sawcer
No evidence for association of the protein kinase C alpha gene with multiple sclerosis.
Journal of neurology 2005;252(5):619-20.
2005: Thomas Foltynie; Andrew Hicks; Stephen Sawcer; Aslaug Jonasdottir; Efrosini Setakis; Mel Maranian; Taiwai Yeo; Simon Lewis; Carol Brayne; Kari Stefansson; Alastair Compston; Jeffrey R Gulcher; Roger A Barker
A genome wide linkage disequilibrium screen in Parkinson's disease.
Journal of neurology 2005;252(5):597-602.
2004: Stephen Sawcer; Mel Maranian; Sara Singlehurst; Taiwai Yeo; Alastair Compston; Mark J Daly; Philip De Jager; Stacey Gabriel; David A Hafler; Adrian J Ivinson; Eric S Lander; John D Rioux; Emily Walsh; Simon G Gregory; Silke Schmidt; Margaret Pericak-Vance; Lisa F Barcellos; Stephen L Hauser; Jorge R Oksenberg; Shannon J Kenealy; Jonathan L Haines
Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping.
Human molecular genetics 2004;13(17):1943-9.
2004: Tai Wai Yeo; Mel Maranian; Sara Singlehurst; Julia Gray; Alastair Compston; Stephen Sawcer
Four single nucleotide polymorphisms from the vitamin D receptor gene in UK multiple sclerosis.
Journal of neurology 2004;251(6):753-4.
2004: Charles Stewart; Roger HORTON; Richard J N Allcock; Jennifer L Ashurst; Alexey Atrazhev; Penny Coggill; Carl Bruder; Simon Forbes; Karen Halls; Joanna M M Howson; Sean Humphray; Sarah Hunt; Andrew Mungall; Kazutoyo Osoegawa; Sophie Palmer; Anne N Roberts; Jane Rogers; Sarah Sims; Yu Wang; Laurens G Wilming; John Elliott; Pieter J de Jong; Stephen Sawcer; John A Todd; John Trowsdale; Stephan Beck
Complete MHC haplotype sequencing for common disease gene mapping.
Genome research 2004;14(6):1176-87.
2004: Karen F Tait; JE Collins; Joanne M Heward; Iain A Eaves; Hywel Snook; Jayne A Franklyn; Anthony H Barnett; John A Todd; Mel Maranian; Alastair Compston; Stephen Sawcer; S C L Gough
Evidence for a Type 1 diabetes-specific mechanism for the insulin gene-associated IDDM2 locus rather than a general influence on autoimmunity.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(3):267-70.
2004: Hanne F Harbo; Benedicte Lie; Stephen Sawcer; Elisabeth Gulowsen Celius; Ke-Zheng Dai; Annette Oturai; Jan Hillert; Aslaug R Lorentzen; M Laaksonen; Kjell-Morten Myhr; lars peter ryder; Sten Fredrikson; Harald Nyland; Per Soelberg Sørensen; Magnhild Sandberg-Wollheim; Oluf Andersen; Arne Svejgaard; A Edland; Svein Ivar Mellgren; Alastair Compston; Frode Vartdal; Anne Spurkland
Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis.
Tissue antigens 2004;63(3):237-47.
2003: Mefkure Eraksoy; Anke Hensiek; M Kurtuncu; Gülsen Akman-Demir; M Kilinc; M Gedizlioglu; B Petek-Balci; O Anlar; Cigdem Kutlu; Güher Saruhan-Direskeneli; Halil A Idrisoglu; Efrosini Setakis; Alastair Compston; Stephen Sawcer
A genome screen for linkage disequilibrium in Turkish multiple sclerosis.
Journal of neuroimmunology 2003;143(1-2):129-32.
2003: Robert Goertsches; Pablo Villoslada; Manuel Comabella; Xavier Montalban; Arcadi Navarro; Emilio G De-la-Concha; Rafael Arroyo; Adolfo Lopez de Munain; David Otaegui; Ricardo Palacios; Jordi Perez-Tur; Aslaug Jonasdottir; Kjartan Benediktsson; Ragnheidur Fossdal; Stephen Sawcer; Efrosini Setakis; Alastair Compston
A genomic screen of Spanish multiple sclerosis patients reveals multiple loci associated with the disease.
Journal of neuroimmunology 2003;143(1-2):124-8.
2003: Francesca Coraddu; Marina Lai; Cristina Mancosu; Eleonora Cocco; Stephen Sawcer; Efrosini Setakis; Alastair Compston; Maria Giovanna Marrosu
A genome-wide screen for linkage disequilibrium in Sardinian multiple sclerosis.
Journal of neuroimmunology 2003;143(1-2):120-3.
2003: Berta Martins Silva; Theodora Thorlacius; Kjartan Benediktsson; Clara Pereira; Ragnheidur Fossdal; Hjortur H Jonsson; Ana Silva; Isabel Leite; J Cerqueira; Paulo Costa; Mónica Marta; Thomas Foltynie; Stephen Sawcer; Alastair Compston; Aslaug Jonasdottir
A whole genome association study in multiple sclerosis patients from north Portugal.
Journal of neuroimmunology 2003;143(1-2):116-9.
2003: Manuela Santos; Jorge Pinto-Basto; M E Rio; M J Sá; A Valença; A Sá; J Dinis; J Figueiredo; L Bigotte de Almeida; I Coelho; Stephen Sawcer; Efrosini Setakis; Alastair Compston; Jorge Sequeiros; Patrícia Maciel
A whole genome screen for association with multiple sclerosis in Portuguese patients.
Journal of neuroimmunology 2003;143(1-2):112-5.
2003: Bartosz Bielecki; Marcin P Mycko; Ewa Tronczyńska; Marek Bieniek; Stephen Sawcer; Efrosini Setakis; Kjartan Benediktsson; Alastair Compston; Krzysztof Selmaj
A whole genome screen for association in Polish multiple sclerosis patients.
Journal of neuroimmunology 2003;143(1-2):107-11.
2003: Hanne F Harbo; Pameli Datta; Annette Oturai; lars peter ryder; Stephen Sawcer; Efrosini Setakis; Eva Akesson; Elisabeth Gulowsen Celius; Helena Modin; Magnhild Sandberg-Wollheim; Kjell-Morten Myhr; Oluf Andersen; Jan Hillert; Per Soelberg Sorensen; Arne Svejgaard; Alastair Compston; Frode Vartdal; Anne Spurkland
Two genome-wide linkage disequilibrium screens in Scandinavian multiple sclerosis patients.
Journal of neuroimmunology 2003;143(1-2):101-6.
2003: Shirley Heggarty; Stephen Sawcer; Stanley Hawkins; Gavin McDonnell; Aidan Droogan; Koen Vandenbroeck; Michael Hutchinson; Efrosini Setakis; Alastair Compston; Colin Graham
A genome wide scan for association with multiple sclerosis in a N. Irish case control population.
Journal of neuroimmunology 2003;143(1-2):93-6.
2003: Aslaug Jonasdottir; Theodora Thorlacius; Ragnheidur Fossdal; Adalbjorg Jonasdottir; Kjartan Benediktsson; John Benedikz; Hjortur H Jonsson; Jesus Sainz; Helga Einarsdottir; Sigrun Sigurdardottir; Gudlaug Kristjansdottir; Stephen Sawcer; Alastair Compston; Kari Stefansson; Jeffrey R Gulcher
A whole genome association study in Icelandic multiple sclerosis patients with 4804 markers.
Journal of neuroimmunology 2003;143(1-2):88-92.
2003: Cecilia Rajda; Krisztina Bencsik; Erika Seres; Aslaug Jonasdottir; Thomas Foltynie; Stephen Sawcer; Kjartan Benediktsson; Ragnheidur Fossdal; Efrosini Setakis; Alastair Compston; László Vécsei
A genome-wide screen for association in Hungarian multiple sclerosis.
Journal of neuroimmunology 2003;143(1-2):84-7.
2003: Alexandra Weber; Carmen Infante-Duarte; Stephen Sawcer; Efrosini Setakis; Judith Bellmann-Strobl; Anke Hensiek; Sandra Rueckert; Constanze Schoenemann; Kjartan Benediktsson; Alastair Compston; Frauke Zipp
A genome-wide German screen for linkage disequilibrium in multiple sclerosis.
Journal of neuroimmunology 2003;143(1-2):79-83.
2003: Mehdi Alizadeh; Emmanuelle Génin; Marie-Claude Babron; Brigitte Birebent; Isabelle Cournu-Rebeix; Jacqueline Yaouanq; Stéphane Dréano; Stephen Sawcer; Alastair Compston; Michel Clanet; Gilles Edan; Bertrand Fontaine; Françoise Clerget-Darpoux; Gilbert Semana
Genetic analysis of multiple sclerosis in Europeans: French data.
Journal of neuroimmunology 2003;143(1-2):74-8.
2003: Mikko Laaksonen; Aslaug Jonasdottir; Ragnheidur Fossdal; Juhani Ruutiainen; Stephen Sawcer; Alastair Compston; Kjartan Benediktsson; Theodora Thorlacius; Jeffrey R Gulcher; Jorma Ilonen
A whole genome association study in Finnish multiple sclerosis patients with 3669 markers.
Journal of neuroimmunology 2003;143(1-2):70-3.
2003: An Goris; Stephen Sawcer; Koen Vandenbroeck; Herwig Carton; An D Billiau; Efrosini Setakis; Alastair Compston; Bénédicte Dubois
New candidate loci for multiple sclerosis susceptibility revealed by a whole genome association screen in a Belgian population.
Journal of neuroimmunology 2003;143(1-2):65-9.
2003: Maria Ban; Stephen Sawcer; Robert Heard; Bruce Bennetts; S Adams; David Booth; V Perich; E Setakis; Alastair Compston; Graeme J Stewart
A genome-wide screen for linkage disequilibrium in Australian HLA-DRB1*1501 positive multiple sclerosis patients.
Journal of neuroimmunology 2003;143(1-2):60-4.
2003: Tai Wai Yeo; Richard Roxburgh; Mel Maranian; Sara Singlehurst; Julia Gray; Anke Hensiek; Efrosini Setakis; Alastair Compston; Stephen Sawcer
Refining the analysis of a whole genome linkage disequilibrium association map: the United Kingdom results.
Journal of neuroimmunology 2003;143(1-2):53-9.
2003: Eva Akesson; Francesca Coraddu; Maria Giovanna Marrosu; Luca Massacesi; Anke Hensiek; Hanne F Harbo; Annette Oturai; Maria Trojano; Patricia Momigliano-Richiardi; Eleonora Cocco; Raffaele Murru; Jan Hillert; Alastair Compston; Stephen Sawcer
Refining the linkage analysis on chromosome 10 in 449 sib-pairs with multiple sclerosis.
Journal of neuroimmunology 2003;143(1-2):31-8.
2003: Anke Hensiek; Richard Roxburgh; B Smilie; Francesca Coraddu; Eva Akesson; P Holmans; Stephen Sawcer; D A S Compston
Updated results of the United Kingdom linkage-based genome screen in multiple sclerosis.
Journal of neuroimmunology 2003;143(1-2):25-30.
2003: Mefkure Eraksoy; M Kurtuncu; Gülsen Akman-Demir; M Kilinc; M Gedizlioglu; M Mirza; O Anlar; Cigdem Kutlu; M Demirkiran; Halil A Idrisoglu; Alastair Compston; Stephen Sawcer
A whole genome screen for linkage in Turkish multiple sclerosis.
Journal of neuroimmunology 2003;143(1-2):17-24.
2003: Stephen Sawcer; Alastair Compston
The genetic analysis of multiple sclerosis in Europeans: concepts and design.
Journal of neuroimmunology 2003;143(1-2):13-6.
2003: Anke Hensiek; Stephen Sawcer; D A S Compston
Searching for needles in haystacks-the genetics of multiple sclerosis and other common neurological diseases.
Brain research bulletin 2003;61(3):229-34.
2003: Anke Hensiek; Richard Roxburgh; M Meranian; Shaun Seaman; Taiwai Yeo; D A S Compston; Stephen Sawcer
Osteopontin gene and clinical severity of multiple sclerosis.
Journal of neurology 2003;250(8):943-7.
2003: Stephen Sawcer; Mel Maranian; Anke Hensiek; Richard Roxburgh; Julia Gray; Alastair Compston
Crohn's associated NOD2 gene variants are not involved in determining susceptibility to multiple sclerosis.
Journal of neurology, neurosurgery, and psychiatry 2003;74(8):1157.
2002: Maria Ban; Graeme J Stewart; Bruce Bennetts; Robert Heard; R Simmons; Mel Maranian; Alastair Compston; Stephen Sawcer
A genome screen for linkage in Australian sibling-pairs with multiple sclerosis.
Genes and immunity 2002;3(8):464-9.
2002: Thomas Foltynie; Stephen Sawcer; Carol Brayne; Roger A Barker
The genetic basis of Parkinson's disease.
Journal of neurology, neurosurgery, and psychiatry 2002;73(4):363-70.
2002: Rene Goedde; Stephen Sawcer; Stefan Boehringer; Bianca Miterski; Eckhart Sindern; Michael Haupts; Sebastian Schimrigk; Alastair Compston; Jörg T Epplen
A genome screen for linkage disequilibrium in HLA-DRB1*15-positive Germans with multiple sclerosis based on 4666 microsatellite markers.
Human genetics 2002;111(3):270-7.
2002: Eva Akesson; Annette Oturai; J Berg; Sten Fredrikson; Oluf Andersen; Hanne F Harbo; M Laaksonen; Kjell-Morten Myhr; Harald Nyland; lars peter ryder; Magnhild Sandberg-Wollheim; Per Soelberg Sorensen; Anne Spurkland; Arne Svejgaard; P Holmans; Alastair Compston; Jan Hillert; Stephen Sawcer
A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis.
Genes and immunity 2002;3(5):279-85.
2002: Richard J N Allcock; Alexey Atrazhev; Stephan Beck; Pieter J de Jong; John Elliott; Simon Forbes; Karen Halls; Roger HORTON; Kazutoyo Osoegawa; Jane Rogers; Stephen Sawcer; John A Todd; John Trowsdale; Y Wang; S Williams
The MHC haplotype project: a resource for HLA-linked association studies.
Tissue antigens 2002;59(6):520-1.
2002: Stephen Sawcer; Mel Maranian; Efrosini Setakis; Val Curwen; Eva Akesson; Anke Hensiek; Francesca Coraddu; Richard Roxburgh; David Sawcer; Julia Gray; Jackie Deans; Peter N Goodfellow; Neil Walker; David Clayton; Alastair Compston
A whole genome screen for linkage disequilibrium in multiple sclerosis confirms disease associations with regions previously linked to susceptibility.
Brain : a journal of neurology 2002;125(Pt 6):1337-47.
2002: Alastair Compston; Stephen Sawcer
Genetic analysis of multiple sclerosis.
Current neurology and neuroscience reports 2002;2(3):259-66.
2002: Anke Hensiek; Stephen Sawcer; R Feakes; Jackie Deans; adrian mander; Eva Akesson; Richard Roxburgh; Francesca Coraddu; S Smith; D A S Compston
HLA-DR 15 is associated with female sex and younger age at diagnosis in multiple sclerosis.
Journal of neurology, neurosurgery, and psychiatry 2002;72(2):184-7.
2001: J Chataway; adrian mander; N Robertson; Stephen Sawcer; Jackie Deans; M Fraser; SA Broadley; David Clayton; Alastair Compston
Multiple sclerosis in sibling pairs: an analysis of 250 families.
Journal of neurology, neurosurgery, and psychiatry 2001;71(6):757-61.
2001: Francesca Coraddu; Stephen Sawcer; Sandra D'Alfonso; Marina Lai; Anke Hensiek; Elisabetta Solla; SA Broadley; Cristina Mancosu; Maura Pugliatti; Maria Giovanna Marrosu; Alastair Compston
A genome screen for multiple sclerosis in Sardinian multiplex families.
European journal of human genetics : EJHG 2001;9(8):621-6.
2001: SA Broadley; Stephen Sawcer; S J Chataway; Francesca Coraddu; Alasdair J Coles; Julia Gray; Richard Roxburgh; David Clayton; D A S Compston
No association between multiple sclerosis and the Notch3 gene responsible for cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Journal of neurology, neurosurgery, and psychiatry 2001;71(1):97-9.
2001: SA Broadley; Stephen Sawcer; Sandra D'Alfonso; Anke Hensiek; Francesca Coraddu; Julia Gray; Richard Roxburgh; David Clayton; C Buttinelli; A Quattrone; M Trojano; Luca Massacesi; Alastair Compston
A genome screen for multiple sclerosis in Italian families.
Genes and immunity 2001;2(4):205-10.
2000: F Larsen; Annette Oturai; lars peter ryder; Hans O Madsen; Jan Hillert; Sten Fredrikson; Magnhild Sandberg-Wollheim; M Laaksonen; Hanne F Harbo; Stephen Sawcer; L Fugger; Per Soelberg Sorensen; Arne Svejgaard
Linkage analysis of a candidate region in Scandinavian sib pairs with multiple sclerosis reveals linkage to chromosome 17q.
Genes and immunity 2000;1(7):456-9.
2000: SA Broadley; Jackie Deans; Stephen Sawcer; David Clayton; D A S Compston
Autoimmune disease in first-degree relatives of patients with multiple sclerosis. A UK survey.
Brain : a journal of neurology 2000;123 ( Pt 6)():1102-11.
2000: R Feakes; Stephen Sawcer; SA Broadley; Francesca Coraddu; Richard Roxburgh; Julia Gray; David Clayton; Alastair Compston
Interleukin 1 receptor antagonist (IL-1ra) in multiple sclerosis.
Journal of neuroimmunology 2000;105(1):96-101.
2000: R Feakes; Stephen Sawcer; B Smillie; J Chataway; SA Broadley; Alastair Compston
No evidence for the involvement of interleukin 2 or the immunoglobulin heavy chain gene cluster in determining genetic susceptibility to multiple sclerosis.
Journal of neurology, neurosurgery, and psychiatry 2000;68(5):679.
2000: SA Broadley; Jackie Deans; S J Chataway; Stephen Sawcer; D A S Compston
Multiple sclerosis and tonsillectomy: no evidence for an influence on the development of disease or clinical phenotype.
Multiple sclerosis (Houndmills, Basingstoke, England) 2000;6(2):121-3.
1999: Annette Oturai; F Larsen; lars peter ryder; Hans O Madsen; Jan Hillert; Sten Fredrikson; Magnhild Sandberg-Wollheim; M Laaksonen; Nils Koch-Henriksen; Stephen Sawcer; L Fugger; Per Soelberg Sorensen; Arne Svejgaard
Linkage and association analysis of susceptibility regions on chromosomes 5 and 6 in 106 Scandinavian sibling pair families with multiple sclerosis.
Annals of neurology 1999;46(4):612-6.
1999: J Chataway; Stephen Sawcer; D Sherman; M Hobart; B Fernie; Francesca Coraddu; R Feakes; SA Broadley; Julia Gray; HB Jones; David Clayton; Peter N Goodfellow; Alastair Compston
No evidence for association of multiple sclerosis with the complement factors C6 and C7.
Journal of neuroimmunology 1999;99(1):150-6.
1999: J Chataway; Stephen Sawcer; R Feakes; Francesca Coraddu; SA Broadley; Julia Gray; Alastair Compston
More evidence that founder effects exist in the European population.
European journal of human genetics : EJHG 1999;7(6):623-4.
1999: J Chataway; Stephen Sawcer; R Feakes; Francesca Coraddu; SA Broadley; HB Jones; David Clayton; Julia Gray; Peter N Goodfellow; Alastair Compston
A screen of candidates from peaks of linkage: evidence for the involvement of myeloperoxidase in multiple sclerosis.
Journal of neuroimmunology 1999;98(2):208-13.
1999: J Chataway; Stephen Sawcer; Francesca Coraddu; R Feakes; SA Broadley; HB Jones; David Clayton; Julia Gray; Peter N Goodfellow; Alastair Compston
Evidence that allelic variants of the spinocerebellar ataxia type 2 gene influence susceptibility to multiple sclerosis.
Neurogenetics 1999;2(2):91-6.
1999: R Feakes; Stephen Sawcer; J Chataway; Francesca Coraddu; SA Broadley; Julia Gray; HB Jones; David Clayton; Peter N Goodfellow; Alastair Compston
Exploring the dense mapping of a region of potential linkage in complex disease: an example in multiple sclerosis.
Genetic epidemiology 1999;17(1):51-63.
1998: Francesca Coraddu; Stephen Sawcer; R Feakes; J Chataway; SA Broadley; HB Jones; David Clayton; Julia Gray; S Smith; C Taylor; Peter N Goodfellow; Alastair Compston
HLA typing in the United Kingdom multiple sclerosis genome screen.
Neurogenetics 1998;2(1):24-33.
1998: R Feakes; J Chataway; Stephen Sawcer; HB Jones; D Clayton; Peter N Goodfellow; Alastair Compston
Susceptibility to multiple sclerosis and the immunoglobulin heavy chain gene cluster.
Annals of neurology 1998;44(6):984.
1998: J Chataway; R Feakes; Francesca Coraddu; Julia Gray; Jackie Deans; M Fraser; N Robertson; SA Broadley; H Jones; David Clayton; P Goodfellow; Stephen Sawcer; Alastair Compston
The genetics of multiple sclerosis: principles, background and updated results of the United Kingdom systematic genome screen.
Brain : a journal of neurology 1998;121 ( Pt 10)():1869-87.
1997: Stephen Sawcer; Peter N Goodfellow; Alastair Compston
The genetic analysis of multiple sclerosis.
Trends in genetics : TIG 1997;13(6):234-9.
1997: Stephen Sawcer; HB Jones; D Judge; F Visser; Alastair Compston; Peter N Goodfellow; David Clayton
Empirical genomewide significance levels established by whole genome simulations.
Genetic epidemiology 1997;14(3):223-9.
1996: Stephen Sawcer; HB Jones; R Feakes; J Gray; N Smaldon; J Chataway; N Robertson; David Clayton; P N Goodfellow; Alastair Compston
A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22.
Nature genetics 1996;13(4):464-8.
1995: Nicholas W Wood; Stephen Sawcer; H F Kellar-Wood; PA Holmans; David Clayton; N Robertson; D A S Compston
Susceptibility to multiple sclerosis and the immunoglobulin heavy chain variable region.
Journal of neurology 1995;242(10):677-82.
1995: Nicholas W Wood; Stephen Sawcer; H F Kellar-Wood; PA Holmans; David Clayton; N Robertson; D A S Compston
The T-cell receptor beta locus and susceptibility to multiple sclerosis.
Neurology 1995;45(10):1859-63.
1995: D A S Compston; H Kellar Wood; N Robertson; Stephen Sawcer; Nicholas W Wood
Genes and susceptibility to multiple sclerosis.
Acta neurologica Scandinavica. Supplementum 1995;161():43-51.