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Tracy Sawchuk

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Ing Swie Goping; Tracy Sawchuk; Aja Rieger; Irene Shostak; R Chris Bleackley
Cytotoxic T lymphocytes overcome Bcl-2 inhibition: target cells contribute to their own demise.
Ing Swie Goping; Tracy Sawchuk; D Alan Underhill; R Chris Bleackley
Identification of {alpha}-tubulin as a granzyme B substrate during CTL-mediated apoptosis.
Kirstin Veugelers; Bruce Motyka; Ing Swie Goping; Irene Shostak; Tracy Sawchuk; R Chris Bleackley
Granule-mediated killing by granzyme B and perforin requires a mannose 6-phosphate receptor and is augmented by cell surface heparan sulfate.

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All Publications

2008: Ing Swie Goping; Tracy Sawchuk; Aja Rieger; Irene Shostak; R Chris Bleackley
Cytotoxic T lymphocytes overcome Bcl-2 inhibition: target cells contribute to their own demise.
Blood 2008;111(4):2142-51.
2006: Ing Swie Goping; Tracy Sawchuk; D Alan Underhill; R Chris Bleackley
Identification of {alpha}-tubulin as a granzyme B substrate during CTL-mediated apoptosis.
Journal of cell science 2006;119(Pt 5):858-65.
2006: Kirstin Veugelers; Bruce Motyka; Ing Swie Goping; Irene Shostak; Tracy Sawchuk; R Chris Bleackley
Granule-mediated killing by granzyme B and perforin requires a mannose 6-phosphate receptor and is augmented by cell surface heparan sulfate.
Molecular biology of the cell 2006;17(2):623-33.
2005: Jonathan C Choy; Rani P Cruz; Alexandra Kerjner; Jennette Geisbrecht; Tracy Sawchuk; Stephanie A Fraser; Dorothy Hudig; R Chris Bleackley; Frank R Jirik; Bruce M McManus; David J Granville
Granzyme B induces endothelial cell apoptosis and contributes to the development of transplant vascular disease.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(3):494-9.
2004: Jonathan C Choy; Vivian H Y Hung; Arwen L Hunter; Paul K Cheung; Bruce Motyka; Ing Swie Goping; Tracy Sawchuk; R Chris Bleackley; Thomas J Podor; Bruce M McManus; David J Granville
Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradation.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(12):2245-50.
2004: Kirstin Veugelers; Bruce Motyka; Christine Frantz; Irene Shostak; Tracy Sawchuk; R Chris Bleackley
The granzyme B-serglycin complex from cytotoxic granules requires dynamin for endocytosis.
Blood 2004;103(10):3845-53.
2003: Ing Swie Goping; Michele Barry; Peter Liston; Tracy Sawchuk; Gabriela Constantinescu; Karolina M Michalak; Irene Shostak; Darren L Roberts; Allison M Hunter; Robert G Korneluk; R Chris Bleackley
Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition.
Immunity 2003;18(3):355-65.
2000: Bruce Motyka; Gregory S Korbutt; Michael J Pinkoski; JA Heibein; A Caputo; ML Hobman; Michele Barry; Irene Shostak; Tracy Sawchuk; Charles F B Holmes; J Gauldie; R Chris Bleackley
Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.
Cell 2000;103(3):491-500.