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Douglas Sawyer

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Laura Pentassuglia; Douglas B Sawyer
ErbB/integrin signaling interactions in regulation of myocardial cell-cell and cell-matrix interactions.
Douglas B Sawyer
Anthracyclines and heart failure.
Oghenerukevwe Odiete; Douglas B Sawyer; Ewa A Konik; Michael F Hill
Type 1 diabetes mellitus abrogates compensatory augmentation of myocardial neuregulin-1β/ErbB in response to myocardial infarction resulting in worsening heart failure.

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All Publications

2013: Laura Pentassuglia; Douglas B Sawyer
ErbB/integrin signaling interactions in regulation of myocardial cell-cell and cell-matrix interactions.
Biochimica et biophysica acta 2013;1833(4):909-16.
2013: Douglas B Sawyer
Anthracyclines and heart failure.
The New England journal of medicine 2013;368(12):1154-6.
2013: Oghenerukevwe Odiete; Douglas B Sawyer; Ewa A Konik; Michael F Hill
Type 1 diabetes mellitus abrogates compensatory augmentation of myocardial neuregulin-1β/ErbB in response to myocardial infarction resulting in worsening heart failure.
Cardiovascular diabetology 2013;12():52.
2013: Michael F Hill; Jennifer Iaci; Marvin W Kronenberg; Carrie G Lenneman; Abigail Murphy; Oghenerukevwe Odiete; Tom J Parry; Amish V Patel; Xuyang Peng; Laura Pentassuglia; Anthony O Caggiano; David B Friedman; Cristi L Galindo; Anindita Ganguly; Frank E Harrell; Holly M Smith; Yanna Song; Maya Srinivas; Zhongming Zhao; Siyuen Zheng; Douglas B Sawyer
Intravenous glial growth factor 2 (GGF2) isoform of neuregulin-1β improves left ventricular function, gene and protein expression in rats after myocardial infarction.
PloS one 2013;8(2):e55741.
2012: Sean P Collins; Gregory J Fermann; Frank E Harrell; Cathy A Jenkins; Christopher J Lindsell; David J Maron; John A McPherson; Karen F Miller; Allen J Naftilan; Sue N Roll; Douglas B Sawyer; Matthew I Sperling; Neal L Weintraub; Alan Storrow
Risk stratification in acute heart failure: rationale and design of the STRATIFY and DECIDE studies.
American heart journal 2012;164(6):825-34.
2012: Gregory J Fermann; Kimberly Hart; Christopher J Lindsell; David J Maron; John A McPherson; Karen F Miller; Allen J Naftilan; Susan Roll; Douglas B Sawyer; Matthew Sperling; Alan Storrow; Neal L Weintraub; Robert H Christenson; Sean P Collins
Galectin 3 complements BNP in risk stratification in acute heart failure.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2012;17(8):706-13.
2012: Oghenerukevwe Odiete; Michael F Hill; Douglas B Sawyer
Neuregulin in cardiovascular development and disease.
Circulation research 2012;111(10):1376-85.
2012: Carrie Geisberg; Laura Pentassuglia; Douglas B Sawyer
Cardiac side effects of anticancer treatments: new mechanistic insights.
Current heart failure reports 2012;9(3):211-8.
2012: Sean P Collins; Gregory J Fermann; Kimberly W Hart; Christopher J Lindsell; Karen F Miller; Susan N Roll; Douglas B Sawyer; Matthew I Sperling; Neal L Weintraub; Alan B Storrow
Elevated urinary neutrophil gelatinase-associated lipocalcin after acute heart failure treatment is associated with worsening renal function and adverse events.
European journal of heart failure 2012;14(9):1020-9.
2012: Sean P Collins; Gregory J Fermann; W Frank Peacock; Phillip D. Levy; Christopher J Lindsell; Peter S Pang; Douglas B Sawyer; Alan B Storrow; Neal Weintraub; Mihai Gheorghiade
Early changes in clinical characteristics after emergency department therapy for acute heart failure syndromes: identifying patients who do not respond to standard therapy.
Heart failure reviews 2012;17(3):387-94.
2012: Basak Icli; Xuyang Peng; Laura Pentassuglia; Ajit Bharti; Douglas B Sawyer
ErbB4 localization to cardiac myocyte nuclei, and its role in myocyte DNA damage response.
Biochemical and biophysical research communications 2012;418(1):116-21.
2012: Billy Chen; Jeffrey M Davidson; Xuyang Peng; Laura Pentassuglia; Sarah F Roush; Susan Samaras; Douglas B Sawyer; Lin Zhong; Chee Chew Lim
Disruption of a GATA4/Ankrd1 signaling axis in cardiomyocytes leads to sarcomere disarray: implications for anthracycline cardiomyopathy.
PloS one 2012;7(4):e35743.
2010: Carrie Anna Geisberg; Douglas B Sawyer
Mechanisms of anthracycline cardiotoxicity and strategies to decrease cardiac damage.
Current hypertension reports 2010;12(6):404-10.
2010: Douglas B Sawyer; Xuyang Peng; Billy Chen; Laura Pentassuglia; Chee Chew Lim
Mechanisms of anthracycline cardiac injury: can we identify strategies for cardioprotection?
Progress in cardiovascular diseases 2010;53(2):105-13.
2009: Laura Pentassuglia; Douglas B Sawyer
The role of Neuregulin-1beta/ErbB signaling in the heart.
Experimental cell research 2009;315(4):627-37.
2009: Thomas A Miller; Basak Icli; Gregory M Cote; Nathan K LeBrasseur; Steven C Borkan; David R Pimentel; Xuyang Peng; Douglas B Sawyer
Palmitate alters neuregulin signaling and biology in cardiac myocytes.
Biochemical and biophysical research communications 2009;379(1):32-7.
2008: Andreia Biolo; Sujata Ramamurthy; Lawreen H Connors; Carl J O'Hara; Hans K Meier-Ewert; Pamela T Soo Hoo; Douglas B Sawyer; David C Seldin; David S Seldin; Flora Sam
Matrix metalloproteinases and their tissue inhibitors in cardiac amyloidosis: relationship to structural, functional myocardial changes and to light chain amyloid deposition.
Circulation. Heart failure 2008;1(4):249-57.
2007: Thomas J Wang; Martin G Larson; Emelia Benjamin; Deborah A Siwik; Radwan Safa; Chao-Yu Guo; Diane Corey; Johan Sundstrom; Douglas B Sawyer; Wilson S Colucci; Ramachandran S Vasan
Clinical and echocardiographic correlates of plasma procollagen type III amino-terminal peptide levels in the community.
American heart journal 2007;154(2):291-7.
2006: Yukio Kuramochi; Xinxin Guo; Douglas B Sawyer
Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes.
Journal of molecular and cellular cardiology 2006;41(2):228-35.
2006: Yukio Kuramochi; Xinxin Guo; Douglas B Sawyer; Chee Chew Lim
Rapid electrical stimulation induces early activation of kinase signal transduction pathways and apoptosis in adult rat ventricular myocytes.
Experimental physiology 2006;91(4):773-80.
2006: Douglas B Sawyer; Martha Skinner
Cardiac amyloidosis: shifting our impressions to hopeful.
Current heart failure reports 2006;3(2):64-71.
2006: Yasuhiro Izumiya; Ichiro Shiojima; Kaori Sato; Douglas B Sawyer; Wilson S Colucci; Kenneth Walsh
Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload.
Hypertension 2006;47(5):887-93.
2006: Eugene Kotlyar; Joseph A Vita; Michael R Winter; Eric H Awtry; Deborah A Siwik; John F Keaney; Douglas B Sawyer; L Adrienne Cupples; Wilson S Colucci; Flora Sam
The relationship between aldosterone, oxidative stress, and inflammation in chronic, stable human heart failure.
Journal of cardiac failure 2006;12(2):122-7.
2005: Gregory M Cote; Thomas A Miller; Nathan K LeBrasseur; Yukio Kuramochi; Douglas B Sawyer
Neuregulin-1alpha and beta isoform expression in cardiac microvascular endothelial cells and function in cardiac myocytes in vitro.
Experimental cell research 2005;311(1):135-46.
2005: Thomas A Miller; Nathan K LeBrasseur; Gregory M Cote; Mario P Trucillo; David R Pimentel; Yasuo Ido; Neil B Ruderman; Douglas B Sawyer
Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes.
Biochemical and biophysical research communications 2005;336(1):309-15.
2005: Flora Sam; David L Kerstetter; David R Pimental; Suresh R Mulukutla; Arash Tabaee; Michael R Bristow; Wilson S Colucci; Douglas B Sawyer
Increased reactive oxygen species production and functional alterations in antioxidant enzymes in human failing myocardium.
Journal of cardiac failure 2005;11(6):473-80.
2005: Nathan K LeBrasseur; Kelly Mizer; Jascha D Parkington; Douglas B Sawyer; Roger A Fielding
The expression of neuregulin and erbB receptors in human skeletal muscle: effects of progressive resistance training.
European journal of applied physiology 2005;94(4):371-5.
2005: xu-yang peng; Billy Chen; Chee Chew Lim; Douglas B Sawyer
The cardiotoxicology of anthracycline chemotherapeutics: translating molecular mechanism into preventative medicine.
Molecular interventions 2005;5(3):163-71.
2005: xu-yang peng; Xinxin Guo; Steven C Borkan; Ajit Bharti; Yukio Kuramochi; Stuart Calderwood; Douglas B Sawyer
Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes.
The Journal of biological chemistry 2005;280(13):13148-52.
2005: Chee Chew Lim; Douglas B Sawyer
Modulation of cardiac function: titin springs into action.
The Journal of general physiology 2005;125(3):249-52.
2005: Nathan A Trueblood; Patrick R Inscore; Daniel Brenner; Daniel Lugassy; Carl S Apstein; Douglas B Sawyer; Wilson S Colucci
Biphasic temporal pattern in exercise capacity after myocardial infarction in the rat: relationship to left ventricular remodeling.
American journal of physiology. Heart and circulatory physiology 2005;288(1):H244-9.
2004: Yukio Kuramochi; Gregory M Cote; Xinxin Guo; Nathan K LeBrasseur; Lei Cui; Ronglih Liao; Douglas B Sawyer
Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling.
The Journal of biological chemistry 2004;279(49):51141-7.
2004: Johan Sundström; Jane Evans; Emelia Benjamin; Daniel Levy; Martin G Larson; Douglas B Sawyer; Deborah A Siwik; Wilson S Colucci; Peter W F Wilson; Ramachandran S Vasan
Relations of plasma total TIMP-1 levels to cardiovascular risk factors and echocardiographic measures: the Framingham heart study.
European heart journal 2004;25(17):1509-16.
2004: Yasuhiro Tanaka; Shigeo Koido; Jianchuan Xia; Masaya Ohana; Chunlei Liu; Gregory M Cote; Douglas B Sawyer; Stuart Calderwood; Jianlin Gong
Development of antigen-specific CD8+ CTL in MHC class I-deficient mice through CD4 to CD8 conversion.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(12):7848-58.
2004: Johan Sundström; Jane Evans; Emelia Benjamin; Daniel Levy; Martin G Larson; Douglas B Sawyer; Deborah A Siwik; Wilson S Colucci; Patrice Sutherland; Peter W F Wilson; Ramachandran S Vasan
Relations of plasma matrix metalloproteinase-9 to clinical cardiovascular risk factors and echocardiographic left ventricular measures: the Framingham Heart Study.
Circulation 2004;109(23):2850-6.
2004: Melanie Maytin; Deborah A Siwik; Masahiro Ito; Lei Xiao; Douglas B Sawyer; Ronglih Liao; Wilson S Colucci
Pressure overload-induced myocardial hypertrophy in mice does not require gp91phox.
Circulation 2004;109(9):1168-71.
2004: Chee Chew Lim; Christian Zuppinger; Xinxin Guo; Gabriela M Kuster; Michiel Helmes; Hans M Eppenberger; Thomas M Suter; Ronglih Liao; Douglas B Sawyer
Anthracyclines induce calpain-dependent titin proteolysis and necrosis in cardiomyocytes.
The Journal of biological chemistry 2004;279(9):8290-9.
2004: Yukio Kuramochi; Chee Chew Lim; Xinxin Guo; Wilson S Colucci; Ronglih Liao; Douglas B Sawyer
Myocyte contractile activity modulates norepinephrine cytotoxicity and survival effects of neuregulin-1beta.
American journal of physiology. Cell physiology 2004;286(2):C222-9.
2003: Ryuji Fukazawa; Thomas A Miller; Yukio Kuramochi; Stefan Frantz; Young Dae Kim; Mark A Marchionni; Ralph A Kelly; Douglas B Sawyer
Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt.
Journal of molecular and cellular cardiology 2003;35(12):1473-9.
2003: Mohit Jain; Daniel A Brenner; Lei Cui; Chee Chew Lim; Bo Wang; David R Pimentel; Stanley Koh; Douglas B Sawyer; Jane A Leopold; Diane E Handy; Joseph Loscalzo; Carl S Apstein; Ronglih Liao
Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes.
Circulation research 2003;93(2):e9-16.
2003: Susan H Kwon; David R Pimentel; Andrea Remondino; Douglas B Sawyer; Wilson S Colucci
H(2)O(2) regulates cardiac myocyte phenotype via concentration-dependent activation of distinct kinase pathways.
Journal of molecular and cellular cardiology 2003;35(6):615-21.
2003: Nathan K LeBrasseur; Gregory M Coté; Thomas A Miller; Roger A Fielding; Douglas B Sawyer
Regulation of neuregulin/ErbB signaling by contractile activity in skeletal muscle.
American journal of physiology. Cell physiology 2003;284(5):C1149-55.
2003: Andrea Remondino; Susan H Kwon; Catherine Communal; David R Pimentel; Douglas B Sawyer; Krishna Singh; Wilson S Colucci
Beta-adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of the mitochondrial pathway.
Circulation research 2003;92(2):136-8.
2003: Michiel Helmes; Chee Chew Lim; Ronglih Liao; Ajit Bharti; Lei Cui; Douglas B Sawyer
Titin determines the Frank-Starling relation in early diastole.
The Journal of general physiology 2003;121(2):97-110.
2002: Douglas B Sawyer; Thomas M Suter; Carl S Apstein
The sting of salt on an old, but open, wound--is Na(+) the cause of mitochondrial and myocardial injury during ischemia/reperfusion?
Journal of molecular and cellular cardiology 2002;34(7):699-702.
2002: Douglas B Sawyer; Christian Zuppinger; Thomas A Miller; Hans M Eppenberger; Thomas M Suter
Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1beta and anti-erbB2: potential mechanism for trastuzumab-induced cardiotoxicity.
Circulation 2002;105(13):1551-4.
2002: Catherine Communal; Wilson S Colucci; Andrea Remondino; Douglas B Sawyer; J. David Port; Scott E Wichman; Michael R Bristow; Krishna Singh
Reciprocal modulation of mitogen-activated protein kinases and mitogen-activated protein kinase phosphatase 1 and 2 in failing human myocardium.
Journal of cardiac failure 2002;8(2):86-92.
2002: Douglas B Sawyer; Deborah A Siwik; Lei Xiao; David R Pimentel; Krishna Singh; Wilson S Colucci
Role of oxidative stress in myocardial hypertrophy and failure.
Journal of molecular and cellular cardiology 2002;34(4):379-88.
2002: Lei Xiao; David R Pimentel; Jing Wang; Krishna Singh; Wilson S Colucci; Douglas B Sawyer
Role of reactive oxygen species and NAD(P)H oxidase in alpha(1)-adrenoceptor signaling in adult rat cardiac myocytes.
American journal of physiology. Cell physiology 2002;282(4):C926-34.
2001: Krishna Singh; Lei Xiao; Andrea Remondino; Douglas B Sawyer; Wilson S Colucci
Adrenergic regulation of cardiac myocyte apoptosis.
Journal of cellular physiology 2001;189(3):257-65.
2001: David R Pimentel; JK Amin; Lei Xiao; T Miller; Jason Viereck; Jennifer M Oliver-Krasinski; R Baliga; Junru Wang; Deborah A Siwik; Krishna Singh; Patrick J Pagano; Wilson S Colucci; Douglas B Sawyer
Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes.
Circulation research 2001;89(5):453-60.
2001: Flora Sam; Douglas B Sawyer; Zhonglin Xie; Donny L F Chang; Soeun Ngoy; Daniel A Brenner; Deborah A Siwik; Krishna Singh; Carl S Apstein; Wilson S Colucci
Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction.
Circulation research 2001;89(4):351-6.
2001: Chee Chew Lim; Michiel Helmes; Douglas B Sawyer; Mohit Jain; Ronglih Liao
High-throughput assessment of calcium sensitivity in skinned cardiac myocytes.
American journal of physiology. Heart and circulatory physiology 2001;281(2):H969-74.
2001: N A Trueblood; Zhonglin Xie; Catherine Communal; Flora Sam; Soeun Ngoy; Lucy Liaw; A W Jenkins; Junru Wang; Douglas B Sawyer; Oscar H L Bing; Carl S Apstein; Wilson S Colucci; Krishna Singh
Exaggerated left ventricular dilation and reduced collagen deposition after myocardial infarction in mice lacking osteopontin.
Circulation research 2001;88(10):1080-7.
2001: Mohit Jain; Harout DerSimonian; Daniel A Brenner; Soeun Ngoy; P Teller; Albert S B Edge; Agatha Zawadzka; Kristie Wetzel; Douglas B Sawyer; Wilson S Colucci; Carl S Apstein; Ronglih Liao
Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction.
Circulation 2001;103(14):1920-7.
2001: Lei Xiao; David R Pimental; JK Amin; Krishna Singh; Douglas B Sawyer; Wilson S Colucci
MEK1/2-ERK1/2 mediates alpha1-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes.
Journal of molecular and cellular cardiology 2001;33(4):779-87.
2001: JK Amin; Lei Xiao; David R Pimental; Patrick J Pagano; Krishna Singh; Douglas B Sawyer; Wilson S Colucci
Reactive oxygen species mediate alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes.
Journal of molecular and cellular cardiology 2001;33(1):131-9.
2000: Flora Sam; Douglas B Sawyer; Donny L F Chang; Franz R Eberli; Soeun Ngoy; Mohit Jain; J Amin; Carl S Apstein; Wilson S Colucci
Progressive left ventricular remodeling and apoptosis late after myocardial infarction in mouse heart.
American journal of physiology. Heart and circulatory physiology 2000;279(1):H422-8.
2000: Wilson S Colucci; Douglas B Sawyer; Krishna Singh; Catherine Communal
Adrenergic overload and apoptosis in heart failure: implications for therapy.
Journal of cardiac failure 2000;6(2 Suppl 1):1-7.
2000: Krishna Singh; Catherine Communal; Douglas B Sawyer; Wilson S Colucci
Adrenergic regulation of myocardial apoptosis.
Cardiovascular research 2000;45(3):713-9.
1999: Catherine Communal; Krishna Singh; Douglas B Sawyer; Wilson S Colucci
Opposing effects of beta(1)- and beta(2)-adrenergic receptors on cardiac myocyte apoptosis : role of a pertussis toxin-sensitive G protein.
Circulation 1999;100(22):2210-2.
1999: R R Baliga; David R Pimental; Youyang Zhao; W W Simmons; M A Marchionni; Douglas B Sawyer; Ralph A Kelly
NRG-1-induced cardiomyocyte hypertrophy. Role of PI-3-kinase, p70(S6K), and MEK-MAPK-RSK.
The American journal of physiology 1999;277(5 Pt 2):H2026-37.
1999: MA Arstall; Douglas B Sawyer; Ryuji Fukazawa; Ralph A Kelly
Cytokine-mediated apoptosis in cardiac myocytes: the role of inducible nitric oxide synthase induction and peroxynitrite generation.
Circulation research 1999;85(9):829-40.
1999: Deborah A Siwik; J D Tzortzis; David R Pimental; Donny L F Chang; Patrick J Pagano; Krishna Singh; Douglas B Sawyer; Wilson S Colucci
Inhibition of copper-zinc superoxide dismutase induces cell growth, hypertrophic phenotype, and apoptosis in neonatal rat cardiac myocytes in vitro.
Circulation research 1999;85(2):147-53.
1999: Douglas B Sawyer; Ryuji Fukazawa; MA Arstall; Ralph A Kelly
Daunorubicin-induced apoptosis in rat cardiac myocytes is inhibited by dexrazoxane.
Circulation research 1999;84(3):257-65.
1998: Douglas B Sawyer; Wilson S Colucci
Nitric oxide in the failing myocardium.
Cardiology clinics 1998;16(4):657-64, viii.