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Jana Sawynok

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Publications

TOP 3
Jana Sawynok; Chok Hiew; Dana Marcon
Chaoyi fanhuan qigong and fibromyalgia: methodological issues and two case reports.
Jean Liu; Allison R Reid; Jana Sawynok
Antinociception by systemically-administered acetaminophen (paracetamol) involves spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors.
Jean Liu; Allison R Reid; Jana Sawynok
Spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors, are involved in antinociception by systemically administered amitriptyline.

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All Publications

2013: Jana Sawynok; Chok Hiew; Dana Marcon
Chaoyi fanhuan qigong and fibromyalgia: methodological issues and two case reports.
Journal of alternative and complementary medicine (New York, N.Y.) 2013;19(4):383-6.
2013: Jean Liu; Allison R Reid; Jana Sawynok
Antinociception by systemically-administered acetaminophen (paracetamol) involves spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors.
Neuroscience letters 2013;536():64-8.
2013: Jean Liu; Allison R Reid; Jana Sawynok
Spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors, are involved in antinociception by systemically administered amitriptyline.
European journal of pharmacology 2013;698(1-3):213-9.
2012: Tsipora Mankovsky; Jana Sawynok; Aj Clark; Mary Lynch; Michael Jl Sullivan
Pain catastrophizing predicts poor response to topical analgesics in patients with neuropathic pain.
Pain research & management : the journal of the Canadian Pain Society = journal de la société canadienne pour le traitement de la douleur 2012;17(1):10-4.
2011: C Peter N Watson; Jana Sawynok; Ian Gilron; Mary E Lynch
Nontricyclic antidepressant analgesics and pain: are serotonin norepinephrine reuptake inhibitors (SNRIs) any better?
Pain 2011;152(10):2206-10.
2011: Jana Sawynok; Allison R Reid
Reduction of formalin-evoked responses and maintenance of peripheral antinociception by morphine against formalin in the spared nerve injury model.
Neuroscience letters 2011;494(2):99-103.
2011: Jana Sawynok
Caffeine and pain.
Pain 2011;152(4):726-9.
2011: Jana Sawynok
Methylxanthines and pain.
Handbook of experimental pharmacology 2011;(200):311-29.
2010: C Peter N Watson; Ian Gilron; Jana Sawynok
A qualitative systematic review of head-to-head randomized controlled trials of oral analgesics in neuropathic pain.
Pain research & management : the journal of the Canadian Pain Society = journal de la société canadienne pour le traitement de la douleur 2010;15(3):147-57.
2010: Jana Sawynok; Allison R Reid; Bertil B. Fredholm
Caffeine reverses antinociception by oxcarbazepine by inhibition of adenosine A1 receptors: insights using knockout mice.
Neuroscience letters 2010;473(3):178-81.
2009: Andre Arsenault; Jana Sawynok
Perisurgical amitriptyline produces a preventive effect on afferent hypersensitivity following spared nerve injury.
Pain 2009;146(3):308-14.
2009: Mary E Lynch; Jana Sawynok; Amanda Bouchard
A pilot trial of CFQ for treatment of fibromyalgia.
Journal of alternative and complementary medicine (New York, N.Y.) 2009;15(10):1057-8.
2008: Jason G Meisner; Allison R Reid; Jana Sawynok
Adrenergic regulation of P2X3 and TRPV1 receptors: differential effects of spared nerve injury.
Neuroscience letters 2008;444(2):172-5.
2008: Jana Sawynok; Allison R Reid; Bertil B. Fredholm
Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors.
Neuroscience letters 2008;440(2):181-4.
2007: Jason G Meisner; James B Waldron; Jana Sawynok
Alpha1-adrenergic receptors augment P2X3 receptor-mediated nociceptive responses in the uninjured state.
The journal of pain : official journal of the American Pain Society 2007;8(7):556-62.
2007: Jana Sawynok
Adenosine and ATP receptors.
Handbook of experimental pharmacology 2007;(177):309-28.
2006: Jana Sawynok; Allison Reid; Jason Meisner
Pain behaviors produced by capsaicin: influence of inflammatory mediators and nerve injury.
The journal of pain : official journal of the American Pain Society 2006;7(2):134-41.
2005: Mary E Lynch; Alexander J Clark; Jana Sawynok; Michael J L Sullivan
Topical amitriptyline and ketamine in neuropathic pain syndromes: an open-label study.
The journal of pain : official journal of the American Pain Society 2005;6(10):644-9.
2005: Jana Sawynok; Allison R Reid; Xue Jun Liu; Fiona E Parkinson
Amitriptyline enhances extracellular tissue levels of adenosine in the rat hindpaw and inhibits adenosine uptake.
European journal of pharmacology 2005;518(2-3):116-22.
2005: Mary E Lynch; Alexander J Clark; Jana Sawynok; Michael J L Sullivan
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
Anesthesiology 2005;103(1):140-6.
2005: Jana Sawynok
Topical analgesics in neuropathic pain.
Current pharmaceutical design 2005;11(23):2995-3004.
2005: Jana Sawynok
Amitriptyline neurotoxicity.
Anesthesiology 2005;102(1):240-1; author reply 241.
2004: James B Waldron; Allison R Reid; Jana Sawynok
Amitriptyline produces multiple influences on the peripheral enhancement of nociception by P2X receptors.
European journal of pharmacology 2004;499(3):275-83.
2004: James B Waldron; Jana Sawynok
Peripheral P2X receptors and nociception: interactions with biogenic amine systems.
Pain 2004;110(1-2):79-89.
2004: James Eisenach; David D Hood; Regina Curry; Jana Sawynok; Tony L Yaksh; Xinhui Li
Intrathecal but not intravenous opioids release adenosine from the spinal cord.
The journal of pain : official journal of the American Pain Society 2004;5(1):64-8.
2004: N Aumeerally; G Allen; Jana Sawynok
Glutamate-evoked release of adenosine and regulation of peripheral nociception.
Neuroscience 2004;127(1):1-11.
2003: Mary E Lynch; Alexander J Clark; Jana Sawynok
A pilot study examining topical amitriptyline, ketamine, and a combination of both in the treatment of neuropathic pain.
The Clinical journal of pain 2003;19(5):323-8.
2003: Mark Oatway; Allison Reid; Jana Sawynok
Peripheral antihyperalgesic and analgesic actions of ketamine and amitriptyline in a model of mild thermal injury in the rat.
Anesthesia and analgesia 2003;97(1):168-73, table of contents.
2003: Mary E Lynch; Alexander J Clark; Jana Sawynok
Intravenous adenosine alleviates neuropathic pain: a double blind placebo controlled crossover trial using an enriched enrolment design.
Pain 2003;103(1-2):111-7.
2003: Jana Sawynok; Allison Reid
Chronic intrathecal cannulas inhibit some and potentiate other behaviors elicited by formalin injection.
Pain 2003;103(1-2):7-9.
2003: Jana Sawynok; Xue Jun Liu
Adenosine in the spinal cord and periphery: release and regulation of pain.
Progress in neurobiology 2003;69(5):313-40.
2003: Jana Sawynok; Allison Reid
Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats.
Pain 2003;102(1-2):179-86.
2003: Jana Sawynok
Topical and peripherally acting analgesics.
Pharmacological reviews 2003;55(1):1-20.
2002: Jana Sawynok; Allison Reid
Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine.
European journal of pharmacology 2002;450(2):153-62.
2002: Caroline E Heughan; Jana Sawynok
The interaction between gabapentin and amitriptyline in the rat formalin test after systemic administration.
Anesthesia and analgesia 2002;94(4):975-80, table of contents.
2002: Xue Jun Liu; Thomas D White; Jana Sawynok
Intraplantar injection of glutamate evokes peripheral adenosine release in the rat hind paw: involvement of peripheral ionotropic glutamate receptors and capsaicin-sensitive sensory afferents.
Journal of neurochemistry 2002;80(4):562-70.
2002: Caroline E Heughan; Gary V Allen; Teena D Chase; Jana Sawynok
Peripheral amitriptyline suppresses formalin-induced Fos expression in the rat spinal cord.
Anesthesia and analgesia 2002;94(2):427-31, table of contents.
2002: Xue Jun Liu; Thomas D White; Jana Sawynok
Enhanced release of adenosine in rat hind paw following spinal nerve ligation: involvement of capsaicin-sensitive sensory afferents.
Neuroscience 2002;114(2):379-87.
2001: MJ Esser; Teena D Chase; Gary V Allen; Jana Sawynok
Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions.
European journal of pharmacology 2001;430(2-3):211-8.
2001: Xue Jun Liu; Thomas D White; Jana Sawynok
Involvement of primary sensory afferents, postganglionic sympathetic nerves and mast cells in the formalin-evoked peripheral release of adenosine.
European journal of pharmacology 2001;429(1-3):147-55.
2001: Jana Sawynok; Allison Reid
Antinociception by tricyclic antidepressants in the rat formalin test: differential effects on different behaviours following systemic and spinal administration.
Pain 2001;93(1):51-9.
2001: Jana Sawynok; MJ Esser; Allison R Reid
Antidepressants as analgesics: an overview of central and peripheral mechanisms of action.
Journal of psychiatry & neuroscience : JPN 2001;26(1):21-9.
2001: Jana Sawynok
Antidepressants as analgesics: an introduction.
Journal of psychiatry & neuroscience : JPN 2001;26(1):20.
2000: Xue Jun Liu; Thomas D White; Jana Sawynok
Potentiation of formalin-evoked adenosine release by an adenosine kinase inhibitor and an adenosine deaminase inhibitor in the rat hind paw: a microdialysis study.
European journal of pharmacology 2000;408(2):143-52.
2000: MJ Esser; Jana Sawynok
Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain.
European journal of pharmacology 2000;399(2-3):131-9.
2000: Jana Sawynok; Allison Reid; Xue Jun Liu
Involvement of mast cells, sensory afferents and sympathetic mechanisms in paw oedema induced by adenosine A(1) and A(2B/3) receptor agonists.
European journal of pharmacology 2000;395(1):47-50.
1999: Jana Sawynok; Allison Reid; Xue Jun Liu
Acute paw oedema induced by local injection of adenosine A(1), A(2) and A(3) receptor agonists.
European journal of pharmacology 1999;386(2-3):253-61.
1999: A Poon; Jana Sawynok
Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor.
European journal of pharmacology 1999;384(2-3):123-38.
1999: Jana Sawynok; MJ Esser; Allison R Reid
Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat.
Pain 1999;82(2):149-58.
1999: MJ Esser; Jana Sawynok
Acute amitriptyline in a rat model of neuropathic pain: differential symptom and route effects.
Pain 1999;80(3):643-53.
1999: Jana Sawynok; Allison R Reid; MJ Esser
Peripheral antinociceptive action of amitriptyline in the rat formalin test: involvement of adenosine.
Pain 1999;80(1-2):45-55.
1998: Jana Sawynok
Adenosine receptor activation and nociception.
European journal of pharmacology 1998;347(1):1-11.
1998: A Poon; Jana Sawynok
Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat.
Pain 1998;74(2-3):235-45.
1998: Jana Sawynok; Allison Reid; A Poon
Peripheral antinociceptive effect of an adenosine kinase inhibitor, with augmentation by an adenosine deaminase inhibitor, in the rat formalin test.
Pain 1998;74(1):75-81.
1997: GJ Doak; Jana Sawynok
Formalin-induced nociceptive behavior and edema: involvement of multiple peripheral 5-hydroxytryptamine receptor subtypes.
Neuroscience 1997;80(3):939-49.
1997: Jana Sawynok; M R Zarrindast; Allison R Reid; GJ Doak
Adenosine A3 receptor activation produces nociceptive behaviour and edema by release of histamine and 5-hydroxytryptamine.
European journal of pharmacology 1997;333(1):1-7.
1997: Jana Sawynok; Allison Reid
Peripheral adenosine 5'-triphosphate enhances nociception in the formalin test via activation of a purinergic p2X receptor.
European journal of pharmacology 1997;330(2-3):115-21.
1997: C M Cahill; Thomas D White; Jana Sawynok
Substance P releases and augments the morphine-evoked release of adenosine from spinal cord.
Brain research 1997;760(1-2):294-7.
1996: K Golembiowska; Thomas D White; Jana Sawynok
Adenosine kinase inhibitors augment release of adenosine from spinal cord slices.
European journal of pharmacology 1996;307(2):157-62.
1996: Jana Sawynok; Allison Reid
Neurotoxin-induced lesions to central serotonergic, noradrenergic and dopaminergic systems modify caffeine-induced antinociception in the formalin test and locomotor stimulation in rats.
The Journal of pharmacology and experimental therapeutics 1996;277(2):646-53.
1996: Jana Sawynok; Allison Reid
Caffeine antinociception: role of formalin concentration and adenosine A1 and A2 receptors.
European journal of pharmacology 1996;298(2):105-11.
1996: C M Cahill; Thomas D White; Jana Sawynok
Synergy between mu/delta-opioid receptors mediates adenosine release from spinal cord synaptosomes.
European journal of pharmacology 1996;298(1):45-9.
1995: K Golembiowska; Thomas D White; Jana Sawynok
Modulation of adenosine release from rat spinal cord by adenosine deaminase and adenosine kinase inhibitors.
Brain research 1995;699(2):315-20.
1995: A Poon; Jana Sawynok
Antinociception by adenosine analogs and an adenosine kinase inhibitor: dependence on formalin concentration.
European journal of pharmacology 1995;286(2):177-84.
1995: C M Cahill; Thomas D White; Jana Sawynok
Spinal opioid receptors and adenosine release: neurochemical and behavioral characterization of opioid subtypes.
The Journal of pharmacology and experimental therapeutics 1995;275(1):84-93.
1995: G J Doak; Jana Sawynok
Complex role of peripheral adenosine in the genesis of the response to subcutaneous formalin in the rat.
European journal of pharmacology 1995;281(3):311-8.
1995: Jana Sawynok; Allison R Reid; G J Doak
Caffeine antinociception in the rat hot-plate and formalin tests and locomotor stimulation: involvement of noradrenergic mechanisms.
Pain 1995;61(2):203-13.
1995: Jana Sawynok
Pharmacological rationale for the clinical use of caffeine.
Drugs 1995;49(1):37-50.
1994: Jana Sawynok; Allison Reid
Spinal supersensitivity to 5-HT1, 5-HT2 and 5-HT3 receptor agonists following 5,7-dihydroxytryptamine.
European journal of pharmacology 1994;264(3):249-57.
1993: M I Sweeney; Thomas D White; Jana Sawynok
Morphine-evoked release of adenosine from the spinal cord occurs via a nucleoside carrier with differential sensitivity to dipyridamole and nitrobenzylthioinosine.
Brain research 1993;614(1-2):301-7.
1993: Jana Sawynok; John W Downie; Allison R Reid; C M Cahill; Thomas D White
ATP release from dorsal spinal cord synaptosomes: characterization and neuronal origin.
Brain research 1993;610(1):32-8.
1993: C M Cahill; Thomas D White; Jana Sawynok
Morphine activates omega-conotoxin-sensitive Ca2+ channels to release adenosine from spinal cord synaptosomes.
Journal of neurochemistry 1993;60(3):894-901.
1993: C M Cahill; Thomas D White; Jana Sawynok
Involvement of calcium channels in depolarization-evoked release of adenosine from spinal cord synaptosomes.
Journal of neurochemistry 1993;60(3):886-93.
1993: C M Cahill; Thomas D White; Jana Sawynok
Influence of calcium on the release of endogenous adenosine from spinal cord synaptosomes.
Life sciences 1993;53(6):487-96.
1992: Jana Sawynok; Allison Reid
Noradrenergic mediation of spinal antinociception by 5-hydroxytryptamine: characterization of receptor subtypes.
European journal of pharmacology 1992;223(1):49-56.
1992: Jana Sawynok; Allison Reid
Desipramine potentiates spinal antinociception by 5-hydroxytryptamine, morphine and adenosine.
Pain 1992;50(1):113-8.
1991: M I Sweeney; Thomas D White; Jana Sawynok
Intracerebroventricular morphine releases adenosine and adenosine 3',5'-cyclic monophosphate from the spinal cord via a serotonergic mechanism.
The Journal of pharmacology and experimental therapeutics 1991;259(3):1013-8.
1991: Jana Sawynok; Allison Reid
Noradrenergic and purinergic involvement in spinal antinociception by 5-hydroxytryptamine and 2-methyl-5-hydroxytryptamine.
European journal of pharmacology 1991;204(3):301-9.
1991: Jana Sawynok; M J Espey; Allison Reid
8-Phenyltheophylline reverses the antinociceptive action of morphine in the periaqueductal gray.
Neuropharmacology 1991;30(8):871-7.
1991: Jana Sawynok; Allison Reid; D Nance
Spinal antinociception by adenosine analogs and morphine after intrathecal administration of the neurotoxins capsaicin, 6-hydroxydopamine and 5,7-dihydroxytryptamine.
The Journal of pharmacology and experimental therapeutics 1991;258(1):370-80.
1991: D Nicholson; Thomas D White; Jana Sawynok
Forskolin and phosphodiesterase inhibitors release adenosine but inhibit morphine-evoked release of adenosine from spinal cord synaptosomes.
Canadian journal of physiology and pharmacology 1991;69(6):877-85.
1991: D Nicholson; A Reid; Jana Sawynok
Effects of forskolin and phosphodiesterase inhibitors on spinal antinociception by morphine.
Pharmacology, biochemistry, and behavior 1991;38(4):753-8.
1990: M I Sweeney; Thomas D White; Jana Sawynok
5-Hydroxytryptamine releases adenosine and cyclic AMP from primary afferent nerve terminals in the spinal cord in vivo.
Brain research 1990;528(1):55-61.
1990: Jana Sawynok; Allison Reid; R Isbrucker
Adenosine mediates calcium-induced antinociception and potentiation of noradrenergic antinociception in the spinal cord.
Brain research 1990;524(2):187-95.
1990: Jana Sawynok; Allison Reid
Supersensitivity to intrathecal 5-hydroxytryptamine, but not noradrenaline, following depletion of spinal 5-hydroxytryptamine by 5,7-dihydroxytryptamine administered into various sites.
Naunyn-Schmiedeberg's archives of pharmacology 1990;342(1):1-8.
1990: Jana Sawynok; M Sweeney; D Nicholson; T White
Pertussis toxin inhibits morphine-induced release of adenosine from the spinal cord.
Progress in clinical and biological research 1990;328():397-400.
1990: Jana Sawynok; D J Nicholson; M I Sweeney; Thomas D White
Adenosine release by morphine and spinal antinociception: role of G-proteins and cyclic AMP.
NIDA research monograph 1990;105():40-6.
1989: Jana Sawynok
The 1988 Merck Frosst Award. The role of ascending and descending noradrenergic and serotonergic pathways in opioid and non-opioid antinociception as revealed by lesion studies.
Canadian journal of physiology and pharmacology 1989;67(9):975-88.
1989: Jana Sawynok; M I Sweeney; T D White
Adenosine release may mediate spinal analgesia by morphine.
Trends in pharmacological sciences 1989;10(5):186-9.
1989: Jana Sawynok; Allison Reid
Lesions to ascending noradrenergic and serotonergic pathways modify antinociception produced by intracerebroventricular administration of morphine.
Neuropharmacology 1989;28(2):141-7.
1989: Jana Sawynok; M I Sweeney
The role of purines in nociception.
Neuroscience 1989;32(3):557-69.
1989: M I Sweeney; Thomas D White; Jana Sawynok
Morphine, capsaicin and K+ release purines from capsaicin-sensitive primary afferent nerve terminals in the spinal cord.
The Journal of pharmacology and experimental therapeutics 1989;248(1):447-54.
1988: Jana Sawynok; Allison Reid
Role of G-proteins and adenylate cyclase in antinociception produced by intrathecal purines.
European journal of pharmacology 1988;156(1):25-34.
1988: M Sweeney; T White; Jana Sawynok
5-Hydroxytryptamine releases adenosine from primary afferent nerve terminals in the spinal cord.
Brain research 1988;462(2):346-9.
1988: Jana Sawynok; Allison Reid
Role of ascending and descending serotonergic pathways in the antinociceptive effect of baclofen.
Naunyn-Schmiedeberg's archives of pharmacology 1988;337(4):359-65.
1988: K Hoehn; Allison Reid; Jana Sawynok
Pertussis toxin inhibits antinociception produced by intrathecal injection of morphine, noradrenaline and baclofen.
European journal of pharmacology 1988;146(1):65-72.
1987: M I Sweeney; Thomas D White; Jana Sawynok
Involvement of adenosine in the spinal antinociceptive effects of morphine and noradrenaline.
The Journal of pharmacology and experimental therapeutics 1987;243(2):657-65.
1987: M I Sweeney; Thomas D White; K H Jhamandas; Jana Sawynok
Morphine releases endogenous adenosine from the spinal cord in vivo.
European journal of pharmacology 1987;141(1):169-70.
1987: Jana Sawynok; Allison Reid
Effect of 6-hydroxydopamine-induced lesions to ascending and descending noradrenergic pathways on morphine analgesia.
Brain research 1987;419(1-2):156-65.
1986: M I Sweeney; Jana Sawynok
Evidence that substance P may be a modulator rather than a transmitter of noxious mechanical stimulation.
Canadian journal of physiology and pharmacology 1986;64(10):1324-7.
1986: Jana Sawynok; M I Sweeney; Thomas D White
Classification of adenosine receptors mediating antinociception in the rat spinal cord.
British journal of pharmacology 1986;88(4):923-30.