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Hideyuki Saya

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Momoko Yoshikawa; Kunio Yoshizawa; Taneaki Nakagawa; Nobuyuki Onishi; Hideyuki Saya; Eiji Sugihara; Kenji Tsuchihashi; Toshifumi Yae; Seiji Asoda; Takatsugu Ishimoto; Hiromasa Kawana; Shuichi Kawashiri; Takashi Masuko; Takeshi Motohara; Makio Mukai; Osamu Nagano
xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma.
Eiji Sugihara; Hideyuki Saya
Complexity of cancer stem cells.
Tomoyuki Osawa; Hideyuki Saya; Eiji Sugihara; Fumio Tashiro; Yuko Atsumi; Masamoto Kanno; Mitsuko Masutani; Ken-Ichi Yoshioka
Arf and p53 act as guardians of a quiescent cellular state by protecting against immortalization of cells with stable genomes.

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2013: Momoko Yoshikawa; Kunio Yoshizawa; Taneaki Nakagawa; Nobuyuki Onishi; Hideyuki Saya; Eiji Sugihara; Kenji Tsuchihashi; Toshifumi Yae; Seiji Asoda; Takatsugu Ishimoto; Hiromasa Kawana; Shuichi Kawashiri; Takashi Masuko; Takeshi Motohara; Makio Mukai; Osamu Nagano
xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma.
Cancer research 2013;73(6):1855-66.
2013: Eiji Sugihara; Hideyuki Saya
Complexity of cancer stem cells.
International journal of cancer. Journal international du cancer 2013;132(6):1249-59.
2013: Tomoyuki Osawa; Hideyuki Saya; Eiji Sugihara; Fumio Tashiro; Yuko Atsumi; Masamoto Kanno; Mitsuko Masutani; Ken-Ichi Yoshioka
Arf and p53 act as guardians of a quiescent cellular state by protecting against immortalization of cells with stable genomes.
Biochemical and biophysical research communications 2013;432(1):34-9.
2013: Takaaki M Goto; Osamu Nagano; Yoshimi Arima; Hideyuki Saya
Lysyl oxidase is induced by cell density-mediated cell cycle suppression via RB-E2F1-HIF-1α axis.
Cell structure and function 2013;38(1):9-14.
2013: Hideaki Naoe; Hideyuki Saya; Tatsuyuki Chiyoda; Jo Ishizawa; Kenta Masuda; Shinji Kuninaka
The APC/C activator Cdh1 regulates the G2/M transition during differentiation of placental trophoblast stem cells.
Biochemical and biophysical research communications 2013;430(2):757-62.
2013: Yuriko Matsuzaki; Yukiyo Mizuguchi; Shoji Fukamachi; Haru Hosokai; Atsushi Shimizu; Hideyuki Saya
Establishment of HRAS(G12V) transgenic medaka as a stable tumor model for in vivo screening of anticancer drugs.
PloS one 2013;8(1):e54424.
2012: Hitoshi Tsugawa; Masanori Hatakeyama; Kenro Hirata; Toshiya Hirayama; Juntaro Matsuzaki; Osamu Nagano; Hideyuki Saya; Hidekazu Suzuki; Toshifumi Hibi
Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells.
Cell host & microbe 2012;12(6):764-77.
2012: Mayumi Tamada; Makoto Suematsu; Hideyuki Saya
Pyruvate kinase M2: multiple faces for conferring benefits on cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(20):5554-61.
2012: Go J Yoshida; Hideyuki Saya
[Therapeutic strategy for breast cancer stem cells].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 7():243-8.
2012: Kosuke Mima; Osamu Nagano; Shigeki Nakagawa; Hirohisa Okabe; Hideyuki Saya; Mayumi Tamada; Masayuki Watanabe; Toru Beppu; Hiromitsu Hayashi; Takatsugu Ishimoto; Hideyuki Kuroki; Hideo Baba
CD44s regulates the TGF-β-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma.
Cancer research 2012;72(13):3414-23.
2012: E Sugihara; T Shimizu; M Andreeff; N Hashimoto; H Honda; J Ishizawa; K Kai; M Kanno; K Kojima; M Miwa; K Nagata; S Okada; N Onishi; Hideyuki Saya
Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor.
Oncogene 2012;31(23):2849-61.
2012: Yoshimi Arima; Hidemi Hayashi; Naoki Hayashi; Kazuharu Kai; Shuji Mikami; Seigo Nakamura; Mikako Sasaki; Eiji Sugihara; Atsushi Yoshida; Eriko Abe; Hideyuki Saya
Loss of p16 expression is associated with the stem cell characteristics of surface markers and therapeutic resistance in estrogen receptor-negative breast cancer.
International journal of cancer. Journal international du cancer 2012;130(11):2568-79.
2012: Tatsuyuki Chiyoda; Yasushi Ishihama; Jo Ishizawa; Masaaki Ito; Kozo Kaibuchi; Yusuke Kobayashi; Hideaki Naoe; Hideyuki Saya; Takatsune Shimizu; Naoyuki Sugiyama; Hiroshi Tsuda; Daisuke Aoki; Yoshimi Arima; Shinji Kuninaka
LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression.
The Journal of cell biology 2012;197(5):625-41.
2012: Tsukasa Oikawa; Masaaki Oyama; Hideyuki Saya; Nobuyuki Udagawa; Shunsuke Uehara; Hiroko Kozuka-Hata; Koichi Matsuo
Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell-cell fusion.
The Journal of cell biology 2012;197(4):553-68.
2012: Mayumi Tamada; Seiji Tateyama; Toshifumi Yae; Takehiro Yamamoto; Hiroshi Yanagawa; Takatsugu Ishimoto; Osamu Nagano; Mitsuyo Ohmura; Nobuyuki Onishi; Makoto Suematsu; Eiji Sugihara; Hideyuki Saya
Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells.
Cancer research 2012;72(6):1438-48.
2012: Yoshimi Arima; Tatsuyuki Chiyoda; Takaaki M Goto; Hidemi Hayashi; Mari Hosonaga; Shinji Kuninaka; Hitoshi Nakagama; Hirokazu Ohata; Mikako Sasaki; Tatsuhiro Shibata; Yoichi Taya; Hideyuki Saya
Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer.
The Journal of biological chemistry 2012;287(11):7896-906.
2012: Takatsune Shimizu; Eiji Sugihara; Yoshiaki Toyama; Arisa Ueki; Tomonori Yaguchi; Hiroshi Ijiri; Yasuo Ikeda; Tomoki Ishikawa; Sayaka Iwai; Yutaka Kawakami; Shinji Kuninaka; Yumi Matsuzaki; Takeshi Miyamoto; Hajime Mori; Hiroshi Nishio; Nobuyuki Onishi; Hideyuki Saya
Fibroblast growth factor-2 is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma.
Molecular cancer research : MCR 2012;10(3):454-68.
2012: Arisa Ueki; Sayaka I Yamaguchi; Takatsune Shimizu; Eiji Sugihara; Yoshiaki Toyama; Daisuke Aoki; Kouji Banno; Tomoki Ishikawa; Shinji Kuninaka; Kenta Masuda; Keita Miyoshi; Akihiro Muto; Nobuyuki Onishi; Hideyuki Saya
Up-regulation of imp3 confers in vivo tumorigenicity on murine osteosarcoma cells.
PloS one 2012;7(11):e50621.
2012: Stéphane Fierro; Osamu Nagano; Hideyuki Saya; Momoko Yoshikawa; Kenji Yoshimi; Yasuaki Einaga
In vivo assessment of cancerous tumors using boron doped diamond microelectrode.
Scientific reports 2012;2():901.
2012: Toshifumi Yae; Go J Yoshida; Momoko Yoshikawa; Hiroyuki Aburatani; Takatsugu Ishimoto; Yasuharu Kanki; Akiko Kubo; Takashi Masuko; Takashi Minami; Kaoru Mogushi; Takeshi Motohara; Mitsuyo Ohmura; Tsuyoshi Osawa; Hideyuki Saya; Makoto Suematsu; Kazuhisa Takahashi; Hiroshi Tanaka; Kenji Tsuchihashi; Takeyuki Wada; Osamu Nagano
Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.
Nature communications 2012;3():883.
2012: Jun Muto; Yoshinori Nishimoto; Daisuke Ogawa; Yohei Okada; Takao Imai; Akio Iwanami; Takeshi Kawase; Yo Mabuchi; Yumi Matsuzaki; Paul S Mischel; Hideyuki Saya; Kazunari Yoshida; Hideyuki Okano
RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways.
PloS one 2012;7(3):e33431.
2011: Takeshi Motohara; Teruyuki Muraguchi; Atsushi Hirao; Takatsugu Ishimoto; Hidetaka Katabuchi; Sachiko Masuko; Yumi Matsuzaki; Nobuyuki Onishi; Hideyuki Saya; Hironori Tashiro; Toshifumi Yae; Osamu Nagano
Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells.
Carcinogenesis 2011;32(11):1597-606.
2011: Oltea Sampetrean; Eiji Sugihara; Hachiro Sugimoto; Masaki Akahata; Raita Fukaya; Atsushi Hirao; Kazuharu Kai; Masaya Nakanishi; Nobuyuki Onishi; Satoru Osuka; Isako Saga; Hideyuki Saya
Invasion precedes tumor mass formation in a malignant brain tumor model of genetically modified neural stem cells.
Neoplasia (New York, N.Y.) 2011;13(9):784-91.
2011: Yusuke Kobayashi; Shinji Kuninaka; Osamu Nagano; Hideaki Naoe; Nobuyuki Onishi; Daisuke Aoki; Kouji Banno; Tatsuyuki Chiyoda; Joe Ishizawa; Takatsune Shimizu; Eiji Sugihara; Arisa Ueki; Hideyuki Saya
Establishment of a choriocarcinoma model from immortalized normal extravillous trophoblast cells transduced with HRASV12.
The American journal of pathology 2011;179(3):1471-82.
2011: Takatsugu Ishimoto; Osamu Nagano; Toshifumi Yae; Mayumi Tamada; Takeshi Motohara; Hiroko Oshima; Masanobu Oshima; Tatsuya Ikeda; Rika Asaba; Hideki Yagi; Takashi Masuko; Takatsune Shimizu; Tomoki Ishikawa; Kazuharu Kai; Eri Takahashi; Yu Imamura; Yoshifumi Baba; Mitsuyo Ohmura; Makoto Suematsu; Hideo Baba; Hideyuki Saya
CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth.
Cancer cell 2011;19(3):387-400.
2011: Go J Yoshida; Hideyuki Saya
[Encounter of cancer cells with bone. The significance of cancer stem cells and epithelial-mesenchymal transition in tumor invasion and metastasis].
Clinical calcium 2011;21(3):411-7.
2011: Masanao Tabuse; Cécile Thirant; Kazunari Yoshida; Hérve Chneiweiss; Raita Fukaya; Yutaka Kawakami; Takeshi Kawase; Yumi Matsuzaki; Aya Misawa; Yohei Ohashi; Shigeki Ohta; Hideyuki Okano; Hideyuki Saya; Masahiro Toda
Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells.
Molecular cancer 2011;10():60.
2010: T Shimizu; Takatoshi Ishikawa; E Sugihara; S Kuninaka; Takeshi Miyamoto; Y Mabuchi; Y Matsuzaki; T Tsunoda; F Miya; H Morioka; R Nakayama; E Kobayashi; Yoshiaki Toyama; A Kawai; H Ichikawa; Tomonobu Hasegawa; S Okada; T Ito; Yasuo Ikeda; Toshio Suda; Hideyuki Saya
c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis.
Oncogene 2010;29(42):5687-99.
2010: Hideaki Naoe; Kimi Araki; Osamu Nagano; Yusuke Kobayashi; Jo Ishizawa; Tatsuyuki Chiyoda; Takatsune Shimizu; Ken-ichi Yamamura; Yutaka Sasaki; Hideyuki Saya; Shinji Kuninaka
The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.
Molecular and cellular biology 2010;30(16):3994-4005.
2010: Yoshimi Arima; Hidemi Hayashi; Kanako Kamata; Takaaki M Goto; Mikako Sasaki; Akira Kuramochi; Hideyuki Saya
Decreased expression of neurofibromin contributes to epithelial-mesenchymal transition in neurofibromatosis type 1.
Experimental dermatology 2010;19(8):e136-41.
2010: Koichiro Miike; Masashi Aoki; Ryo Yamashita; Yumiko Takegawa; Hideyuki Saya; Teruhisa Miike; Ken-ichi Yamamura
Proteome profiling reveals gender differences in the composition of human serum.
Proteomics 2010;10(14):2678-91.
2010: Kazuharu Kai; Yoshimi Arima; Toshio Kamiya; Hideyuki Saya
Breast cancer stem cells.
Breast cancer (Tokyo, Japan) 2010;17(2):80-5.
2010: Chiyo K Imamura; Naoko Takebe; Seigo Nakamura; Hideyuki Saya; Naoto T Ueno
Experimental therapies: Investigator-initiated cancer trials with INDs for approval in Japan.
Nature reviews. Clinical oncology 2010;7(3):127-8.
2010: Takatsugu Ishimoto; Hiroko Oshima; Masanobu Oshima; Kazuharu Kai; Ryota Torii; Takashi Masuko; Hideo Baba; Hideyuki Saya; Osamu Nagano
CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis.
Cancer science 2010;101(3):673-8.
2010: Eri Takahashi; Osamu Nagano; Takatsugu Ishimoto; Toshifumi Yae; Yoshimi Suzuki; Takeshi Shinoda; Satoshi Nakamura; Shinichiro Niwa; Shun Ikeda; Hisashi Koga; Hidenobu Tanihara; Hideyuki Saya
Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction.
The Journal of biological chemistry 2010;285(6):4060-73.
2010: Yumi Nagahama; Masaya Ueno; Satoru Miyamoto; Eiichi Morii; Takashi Minami; Naoki Mochizuki; Hideyuki Saya; Nobuyuki Takakura
PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties.
Cancer research 2010;70(3):1215-24.
2009: Kazuharu Kai; Osamu Nagano; Eiji Sugihara; Yoshimi Arima; Oltea Sampetrean; Takatsugu Ishimoto; Masaya Nakanishi; Naoto T Ueno; Hirotaka Iwase; Hideyuki Saya
Maintenance of HCT116 colon cancer cell line conforms to a stochastic model but not a cancer stem cell model.
Cancer science 2009;100(12):2275-82.
2009: Jo Ishizawa; Hideyuki Saya
[Current clinical trials using new targeted therapies for myeloid leukemia and the research trends].
Nihon rinsho. Japanese journal of clinical medicine 2009;67(10):1932-7.
2009: Shuchin Tei; Noriko Saitoh; Tetsushi Funahara; Shin-Ichi Iida; Yuko Nakatsu; Kayo Kinoshita; Yoshikazu Kinoshita; Hideyuki Saya; Mitsuyoshi Nakao
Simian virus 40 large T antigen targets the microtubule-stabilizing protein TACC2.
Journal of cell science 2009;122(Pt 17):3190-8.
2009: Hiroshi Mochimaru; Eri Takahashi; Nobuo Tsukamoto; Junichiro Miyazaki; Tomonori Yaguchi; Takashi Koto; Toshihide Kurihara; Kousuke Noda; Yoko Ozawa; Takatsugu Ishimoto; Yutaka Kawakami; Hidenobu Tanihara; Hideyuki Saya; Susumu Ishida; Kazuo Tsubota
Involvement of hyaluronan and its receptor CD44 with choroidal neovascularization.
Investigative ophthalmology & visual science 2009;50(9):4410-5.
2009: Hideyuki Saya
[Molecular mechanism of cell death induced by chemotherapeutic agents].
Brain and nerve = Shinkei kenkyū no shinpo 2009;61(7):843-7.
2009: Junko Inumaru; Osamu Nagano; Eri Takahashi; Takatsugu Ishimoto; Satoshi Nakamura; Yoshimi Suzuki; Shin-Ichiro Niwa; Kazuo Umezawa; Hidenobu Tanihara; Hideyuki Saya
Molecular mechanisms regulating dissociation of cell-cell junction of epithelial cells by oxidative stress.
Genes to cells : devoted to molecular & cellular mechanisms 2009;14(6):703-16.
2009: Hideyuki Saya; Dongwei Zhang; Sampetrean Oltea
[Mitotic regulation and carcinogenesis].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2009;54(4 Suppl):561-7.
2009: Oltea Sampetrean; Shin-ichi Iida; Shinji Makino; Yuriko Matsuzaki; Kikuo Ohno; Hideyuki Saya
Reversible whole-organism cell cycle arrest in a living vertebrate.
Cell cycle (Georgetown, Tex.) 2009;8(4):620-7.
2009: Hideyuki Saya
[Molecular mechanism regulating effect of anti-cancer agents].
Gan to kagaku ryoho. Cancer & chemotherapy 2009;36(1):1-5.
2008: Manabu Taura; Ayaka Eguma; Mary Ann Suico; Tsuyoshi Shuto; Tomoaki Koga; Kensei Komatsu; Takefumi Komune; Takashi Sato; Hideyuki Saya; Jian-Dong Li; Hirofumi Kai
p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines.
Molecular and cellular biology 2008;28(21):6557-67.
2008: Yoshinori Muto; Takashi Yoshioka; Masashi Kimura; Miki Matsunami; Hideyuki Saya; Yukio Okano
An evolutionarily conserved leucine-rich repeat protein CLERC is a centrosomal protein required for spindle pole integrity.
Cell cycle (Georgetown, Tex.) 2008;7(17):2738-48.
2008: Hideyuki Saya; Osamu Nagano
[Role of CD44-mediated signal in cancer invasion and metastasis].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2008;53(10):1225-30.
2008: Dongwei Zhang; T Shimizu; Norie Araki; Toru Hirota; M Yoshie; K Ogawa; N Nakagata; Motohiro Takeya; Hideyuki Saya
Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice.
Oncogene 2008;27(31):4305-14.
2008: Yoshimi Arima; Yasumichi Inoue; Tatsuhiro Shibata; Hidemi Hayashi; Osamu Nagano; Hideyuki Saya; Yoichi Taya
Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition.
Cancer research 2008;68(13):5104-12.
2008: Hyun-Ja Nam; Sujeong Kim; Min-Woo Lee; Bok-Soon Lee; Toshihiro Hara; Hideyuki Saya; Hyeseong Cho; Jae-Ho Lee
The ERK-RSK1 activation by growth factors at G2 phase delays cell cycle progression and reduces mitotic aberrations.
Cellular signalling 2008;20(7):1349-58.
2008: Keisuke Oguma; Hiroko Oshima; Masahiro Aoki; Ryusei Uchio; Kazuhito Naka; Satoshi Nakamura; Atsushi Hirao; Hideyuki Saya; Makoto M Taketo; Masanobu Oshima
Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells.
The EMBO journal 2008;27(12):1671-81.
2008: Sungsub Kim; S-Y Park; H Yong; J K Famulski; S Chae; Jun Haeng Lee; C-M Kang; Hideyuki Saya; G K Chan; Hyeseong Cho
HBV X protein targets hBubR1, which induces dysregulation of the mitotic checkpoint.
Oncogene 2008;27(24):3457-64.
2008: Zsuzsanna Pályi-Krekk; Mark Barok; Tamás Kovács; Hideyuki Saya; Osamu Nagano; János Szöllosi; Péter Nagy
EGFR and ErbB2 are functionally coupled to CD44 and regulate shedding, internalization and motogenic effect of CD44.
Cancer letters 2008;263(2):231-42.
2008: Siriporn Patrakitkomjorn; Daiki Kobayashi; Takashi Morikawa; Masayo Morifuji Wilson; Nobuyuki Tsubota; Atsushi Irie; Tatsuya Ozawa; Masashi Aoki; Nariko Arimura; Kozo Kaibuchi; Hideyuki Saya; Norie Araki
Neurofibromatosis type 1 (NF1) tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein, CRMP-2.
The Journal of biological chemistry 2008;283(14):9399-413.
2007: Naoko Ohtani; Yuko Imamura; Kimi Yamakoshi; Fumiko Hirota; Rika Nakayama; Yoshiaki Kubo; Naozumi Ishimaru; Akiko Takahashi; Atsushi Hirao; Takatsune Shimizu; David J Mann; Hideyuki Saya; Yoshio Hayashi; Seiji Arase; Mitsuru Matsumoto; Nakao Kazuki; Eiji Hara
Visualizing the dynamics of p21(Waf1/Cip1) cyclin-dependent kinase inhibitor expression in living animals.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(38):15034-9.
2007: Christian BRONNER; Mayada Achour; Yoshimi Arima; Thierry Chataigneau; Hideyuki Saya; Valérie B Schini-Kerth
The UHRF family: oncogenes that are drugable targets for cancer therapy in the near future?
Pharmacology & therapeutics 2007;115(3):419-34.
2007: Toyotaka Iguchi; Yoshitaka Miyakawa; Kaori Saito; Chika Nakabayashi; Makoto Nakanishi; Hideyuki Saya; Yasuo Ikeda; Masahiro Kizaki
Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells.
International journal of oncology 2007;31(2):285-91.
2007: Shigenori Homma; Yoshihiro Komohara; Mamoru Harada; Hideyuki Saya; Satoru Todo; Kyogo Itoh; Masanori Noguchi
Differential levels of human leukocyte antigen-class I, multidrug-resistance 1 and androgen receptor expressions in untreated prostate cancer cells: the robustness of prostate cancer.
Oncology reports 2007;18(2):343-6.
2007: Shinji Kuninaka; Shin-Ichi Iida; Toshihiro Hara; Masanobu Nomura; H Naoe; Tetsuro Morisaki; Masayuki Nitta; Yoshimi Arima; Tatsuyuki Mimori; S Yonehara; Hideyuki Saya
Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation.
Oncogene 2007;26(17):2395-406.
2007: Hideyuki Saya
[Aurora kinases: Functions and roles in tumorigenesis].
Seikagaku. The Journal of Japanese Biochemical Society 2007;79(2):131-9.
2007: Yasuo Takamune; Tetsuro Ikebe; Osamu Nagano; Hideki Nakayama; Kazutoshi Ota; Takehisa Obayashi; Hideyuki Saya; Masanori Shinohara
ADAM-17 associated with CD44 cleavage and metastasis in oral squamous cell carcinoma.
Virchows Archiv : an international journal of pathology 2007;450(2):169-77.
2007: Daisuke Mori; Yoshihisa Yano; Kazuhito Toyo-Oka; Noriyuki Yoshida; Masami Yamada; Masami Muramatsu; Dongwei Zhang; Hideyuki Saya; Yoko Y Toyoshima; Kazuhisa Kinoshita; Anthony Wynshaw-Boris; Shinji Hirotsune
NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment.
Molecular and cellular biology 2007;27(1):352-67.
2006: Akiko Takahashi; Naoko Ohtani; Kimi Yamakoshi; Shin-ichi Iida; Hidetoshi Tahara; Keiko Nakayama; Keiichi I Nakayama; Toshinori Ide; Hideyuki Saya; Eiji Hara
Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence.
Nature cell biology 2006;8(11):1291-7.
2006: Takayuki Nitta; Masayuki Kanai; Eiji Sugihara; Masakazu Tanaka; Binlian Sun; Toshiro Nagasawa; Shunro Sonoda; Hideyuki Saya; Masanao Miwa
Centrosome amplification in adult T-cell leukemia and human T-cell leukemia virus type 1 Tax-induced human T cells.
Cancer science 2006;97(9):836-41.
2006: Kazuhisa Kinoshita; Hideyuki Saya
[Dynamics of mitotic spindle].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2006;51(6 Suppl):761-6.
2006: Eiji Sugihara; Masayuki Kanai; Soichiro Saito; Takayuki Nitta; Hideo Toyoshima; Keiko Nakayama; Keiichi I Nakayama; Kenji Fukasawa; Manfred Schwab; Hideyuki Saya; Masanao Miwa
Suppression of centrosome amplification after DNA damage depends on p27 accumulation.
Cancer research 2006;66(8):4020-9.
2006: Chandra Bartholomeusz; Hiroaki Itamochi; M Nitta; Hideyuki Saya; M H Ginsberg; Naoto T Ueno
Antitumor effect of E1A in ovarian cancer by cytoplasmic sequestration of activated ERK by PEA15.
Oncogene 2006;25(1):79-90.
2005: Tatsuya Ozawa; Norie Araki; Shunji Yunoue; Hiroshi Tokuo; Liping Feng; Siriporn Patrakitkomjorn; Toshihiro Hara; Yasuko Ichikawa; Kunio Matsumoto; Kiyotaka Fujii; Hideyuki Saya
The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway.
The Journal of biological chemistry 2005;280(47):39524-33.
2005: Hideyuki Saya
[Molecular mechanisms of brain tumor invasion].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 9():61-7.
2005: Shinji Kuninaka; Masanobu Nomura; Toru Hirota; Shin-Ichi Iida; Toshihiro Hara; Shinobu Honda; Naoko Kunitoku; Takashi Sasayama; Yoshimi Arima; Tomotoshi Marumoto; Kageharu Koja; Shin Yonehara; Hideyuki Saya
The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death.
Oncogene 2005;24(34):5287-98.
2005: Takashi Okada; Eiichiro Sonoda; Michio Yoshimura; Yoshiaki Kawano; Hideyuki Saya; Masaoki Kohzaki; Shunichi Takeda
Multiple roles of vertebrate REV genes in DNA repair and recombination.
Molecular and cellular biology 2005;25(14):6103-11.
2005: Takashi Sasayama; Tomotoshi Marumoto; Naoko Kunitoku; Dongwei Zhang; Norihiko Tamaki; Eiji Kohmura; Hideyuki Saya; Toru Hirota
Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(7):627-38.
2005: Yoshimi Arima; Masayuki Nitta; Shinji Kuninaka; Dongwei Zhang; Toshiyoshi Fujiwara; Yoichi Taya; Mitsuyoshi Nakao; Hideyuki Saya
Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria.
The Journal of biological chemistry 2005;280(19):19166-76.
2005: Tatsuo Hata; Toru Furukawa; Makoto Sunamura; Shinichi Egawa; Fuyuhiko Motoi; Noriyuki Ohmura; Tomotoshi Marumoto; Hideyuki Saya; Akira Horii
RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells.
Cancer research 2005;65(7):2899-905.
2005: Xiaochun Yu; Katherine Minter-Dykhouse; Liviu Malureanu; Wei-Meng Zhao; Dongwei Zhang; Carolin J Merkle; Irene M Ward; Hideyuki Saya; Guowei Fang; Jan M A van Deursen; Junjie Chen
Chfr is required for tumor suppression and Aurora A regulation.
Nature genetics 2005;37(4):401-6.
2005: Hisashi Koga; Ichiro Izawa; Norie Araki; Hideyuki Saya; Tatsuyuki Mimori
Observation of the intracellular behavior of recombinant Yersinia pseudotuberculosis invasin protein.
Microbiology and immunology 2005;49(4):297-302.
2005: Tomotoshi Marumoto; Dongwei Zhang; Hideyuki Saya
Aurora-A - a guardian of poles.
Nature reviews. Cancer 2005;5(1):42-50.
2004: Osamu Nagano; Hideyuki Saya
Mechanism and biological significance of CD44 cleavage.
Cancer science 2004;95(12):930-5.
2004: Dongwei Zhang; Toru Hirota; Tomotoshi Marumoto; Michio Shimizu; Naoko Kunitoku; Takashi Sasayama; Yoshimi Arima; Liping Feng; Misao Suzuki; Motohiro Takeya; Hideyuki Saya
Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models.
Oncogene 2004;23(54):8720-30.
2004: Masayuki Nitta; Osamu Kobayashi; Shinobu Honda; Toru Hirota; Shinji Kuninaka; Tomotoshi Marumoto; Yukitaka Ushio; Hideyuki Saya
Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents.
Oncogene 2004;23(39):6548-58.
2004: Shin-Ichi Iida; Toru Hirota; Tetsuro Morisaki; Tomotoshi Marumoto; Toshihiro Hara; Shinji Kuninaka; Shinobu Honda; Ken-ichiro Kosai; Michio Kawasuji; David C Pallas; Hideyuki Saya
Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function.
Oncogene 2004;23(31):5266-74.
2004: Osamu Nagano; Daizo Murakami; Dieter Hartmann; Bart De Strooper; Paul Saftig; Takeshi Iwatsubo; Motowo Nakajima; Masanori Shinohara; Hideyuki Saya
Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation.
The Journal of cell biology 2004;165(6):893-902.
2004: Tamotsu Sudo; Masayuki Nitta; Hideyuki Saya; Naoto T Ueno
Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint.
Cancer research 2004;64(7):2502-8.
2004: Yoshihiro Yasui; Takeshi Urano; Aie Kawajiri; Koh-ichi Nagata; Masaaki Tatsuka; Hideyuki Saya; Koichi Furukawa; Toshitada Takahashi; Ichiro Izawa; Masaki Inagaki
Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis.
The Journal of biological chemistry 2004;279(13):12997-3003.
2004: Shinobu Honda; Tomotoshi Marumoto; Toru Hirota; Masayuki Nitta; Yoshimi Arima; Michio Ogawa; Hideyuki Saya
Activation of m-calpain is required for chromosome alignment on the metaphase plate during mitosis.
The Journal of biological chemistry 2004;279(11):10615-23.
2004: Yoshimi Arima; Toru Hirota; Christian BRONNER; Marc Mousli; Toshiyoshi Fujiwara; Shin-ichiro Niwa; Hiroyuki Ishikawa; Hideyuki Saya
Down-regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition.
Genes to cells : devoted to molecular & cellular mechanisms 2004;9(2):131-42.
2004: Liping Feng; Shunji Yunoue; Hiroshi Tokuo; Tatsuya Ozawa; Dongwei Zhang; Siriporn Patrakitkomjorn; Toru Ichimura; Hideyuki Saya; Norie Araki
PKA phosphorylation and 14-3-3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin.
FEBS letters 2004;557(1-3):275-82.
2004: Tamotsu Sudo; Naoto T Ueno; Hideyuki Saya
Functional analysis of APC-Cdh1.
Methods in molecular biology (Clifton, N.J.) 2004;281():189-98.
2003: Tomotoshi Marumoto; Shinobu Honda; Toshihiro Hara; Masayuki Nitta; Toru Hirota; Eiji Kohmura; Hideyuki Saya
Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells.
The Journal of biological chemistry 2003;278(51):51786-95.
2003: Naoko Kunitoku; Takashi Sasayama; Tomotoshi Marumoto; Dongwei Zhang; Shinobu Honda; Osamu Kobayashi; Katsuyoshi Hatakeyama; Yukitaka Ushio; Hideyuki Saya; Toru Hirota
CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function.
Developmental cell 2003;5(6):853-64.
2003: Naoki Shinojima; Kenji Tada; Shoji Shiraishi; Takanori Kamiryo; Masato Kochi; Hideo Nakamura; Keishi Makino; Hideyuki Saya; Hirofumi Hirano; Jun-ichi Kuratsu; Koji Oka; Yasuji Ishimaru; Yukitaka Ushio
Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme.
Cancer research 2003;63(20):6962-70.
2003: Kenji Tada; Masato Kochi; Hideyuki Saya; Jun-ichi Kuratsu; Shoji Shiraishi; Takanori Kamiryo; Naoki Shinojima; Yukitaka Ushio
Preliminary observations on genetic alterations in pilocytic astrocytomas associated with neurofibromatosis 1.
Neuro-oncology 2003;5(4):228-34.
2003: Toru Hirota; Naoko Kunitoku; Takashi Sasayama; Tomotoshi Marumoto; Dongwei Zhang; Masayuki Nitta; Katsuyoshi Hatakeyama; Hideyuki Saya
Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells.
Cell 2003;114(5):585-98.
2003: Kazuki N Sugahara; Toshiyuki Murai; Hitomi Nishinakamura; Hiroto Kawashima; Hideyuki Saya; Masayuki Miyasaka
Hyaluronan oligosaccharides induce CD44 cleavage and promote cell migration in CD44-expressing tumor cells.
The Journal of biological chemistry 2003;278(34):32259-65.
2003: Shunji Yunoue; Hiroshi Tokuo; Kohji Fukunaga; Liping Feng; Tatsuya Ozawa; Toru Nishi; Akira Kikuchi; Seisuke Hattori; Jun-ichi Kuratsu; Hideyuki Saya; Norie Araki
Neurofibromatosis type I tumor suppressor neurofibromin regulates neuronal differentiation via its GTPase-activating protein function toward Ras.
The Journal of biological chemistry 2003;278(29):26958-69.
2003: Kazuhito Matsuzaki; Takeshi Minami; Masahide Tojo; Yoshiomi Honda; Yasuhiro Uchimura; Hisato Saitoh; Hideyo Yasuda; Shinji Nagahiro; Hideyuki Saya; Mitsuyoshi Nakao
Serum response factor is modulated by the SUMO-1 conjugation system.
Biochemical and biophysical research communications 2003;306(1):32-8.
2003: Yukitaka Ushio; Kenji Tada; Shoji Shiraishi; Takanori Kamiryo; Naoki Shinojima; Masato Kochi; Hideyuki Saya
Correlation of molecular genetic analysis of p53, MDM2, p16, PTEN, and EGFR and survival of patients with anaplastic astrocytoma and glioblastoma.
Frontiers in bioscience : a journal and virtual library 2003;8():e281-8.
2003: Naoyuki Fujita; Sugiko Watanabe; Takaya Ichimura; Yoshiaki Ohkuma; Tsutomu Chiba; Hideyuki Saya; Mitsuyoshi Nakao
MCAF mediates MBD1-dependent transcriptional repression.
Molecular and cellular biology 2003;23(8):2834-43.
2003: Daizo Murakami; Isamu Okamoto; Osamu Nagano; Yoshiaki Kawano; Taisuke Tomita; Takeshi Iwatsubo; Bart De Strooper; Eiji Yumoto; Hideyuki Saya
Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.
Oncogene 2003;22(10):1511-6.
2003: Kazuhiko Watabe; Tsuyoshi Sakamoto; Yoko Kawazoe; Makoto Michikawa; Katsuichi Miyamoto; Takashi Yamamura; Hideyuki Saya; Norie Araki
Tissue culture methods to study neurological disorders: establishment of immortalized Schwann cells from murine disease models.
Neuropathology : official journal of the Japanese Society of Neuropathology 2003;23(1):68-78.
2003: Kazuhito Matsuzaki; Takeshi Minami; Masahide Tojo; Yoshiomi Honda; Noriko Saitoh; Shinji Nagahiro; Hideyuki Saya; Mitsuyoshi Nakao
PML-nuclear bodies are involved in cellular serum response.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(3):275-86.
2002: Masahide Tojo; Kazuhito Matsuzaki; Takeshi Minami; Yoshiomi Honda; Hideyo Yasuda; Tsutomu Chiba; Hideyuki Saya; Yoshiaki Fujii-Kuriyama; Mitsuyoshi Nakao
The aryl hydrocarbon receptor nuclear transporter is modulated by the SUMO-1 conjugation system.
The Journal of biological chemistry 2002;277(48):46576-85.
2002: Tomotoshi Marumoto; Toru Hirota; Tetsuro Morisaki; Naoko Kunitoku; Dongwei Zhang; Yasuko Ichikawa; Takashi Sasayama; Shinji Kuninaka; Tatsuyuki Mimori; Norihiko Tamaki; Masashi Kimura; Yukio Okano; Hideyuki Saya
Roles of aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells.
Genes to cells : devoted to molecular & cellular mechanisms 2002;7(11):1173-82.
2002: Tetsuro Morisaki; Toru Hirota; Shin-ichi Iida; Tomotoshi Marumoto; Toshihiro Hara; Yasuyuki Nishiyama; Michio Kawasuzi; Takehisa Hiraoka; Tatsuyuki Mimori; Norie Araki; Ichiro Izawa; Masaki Inagaki; Hideyuki Saya
WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis.
FEBS letters 2002;529(2-3):319-24.
2002: Hirofumi Ochi; Izumi Horiuchi; Norie Araki; Tosifusa Toda; Tomohiro Araki; Kaori Sato; Hiroyuki Murai; Manabu Osoegawa; Takeshi Yamada; Ken Okamura; Tomoaki Ogino; Kiyohisa Mizumoto; Hirohumi Yamashita; Hideyuki Saya; Jun-ichi Kira
Proteomic analysis of human brain identifies alpha-enolase as a novel autoantigen in Hashimoto's encephalopathy.
FEBS letters 2002;528(1-3):197-202.
2002: Shoji Shiraishi; Kenji Tada; Hideo Nakamura; Keishi Makino; Masato Kochi; Hideyuki Saya; Jun-ichi Kuratsu; Yukitaka Ushio
Influence of p53 mutations on prognosis of patients with glioblastoma.
Cancer 2002;95(2):249-57.
2002: Takanori Kamiryo; Kenji Tada; Shoji Shiraishi; Naoki Shinojima; Hideo Nakamura; Masato Kochi; Jun-ichi Kuratsu; Hideyuki Saya; Yukitaka Ushio
Analysis of homozygous deletion of the p16 gene and correlation with survival in patients with glioblastoma multiforme.
Journal of neurosurgery 2002;96(5):815-22.
2002: Masayuki Nitta; Hiromasa Tsuiki; Yoshimi Arima; Kei Harada; Takahumi Nishizaki; Kousuke Sasaki; Tatsuyuki Mimori; Yukitaka Ushio; Hideyuki Saya
Hyperploidy induced by drugs that inhibit formation of microtubule promotes chromosome instability.
Genes to cells : devoted to molecular & cellular mechanisms 2002;7(2):151-62.
2002: Isamu Okamoto; Hiromasa Tsuiki; Lawrence C Kenyon; Andrew K Godwin; David R Emlet; Marina Holgado-Madruga; Irene S Lanham; Christopher J Joynes; Kim T Vo; Abhijit Guha; Mitsuhiro Matsumoto; Yukitaka Ushio; Hideyuki Saya; Albert J Wong
Proteolytic cleavage of the CD44 adhesion molecule in multiple human tumors.
The American journal of pathology 2002;160(2):441-7.
2002: Yoshiomi Honda; Masahide Tojo; Kazuhito Matsuzaki; Tadashi Anan; Mitsuhiro Matsumoto; Masayuki Ando; Hideyuki Saya; Mitsuyoshi Nakao
Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response.
The Journal of biological chemistry 2002;277(5):3599-605.
2001: Isamu Okamoto; Yoshiaki Kawano; Daizo Murakami; Takashi Sasayama; N Araki; T Miki; A J Wong; Hideyuki Saya
Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway.
The Journal of cell biology 2001;155(5):755-62.
2001: T Sudo; Y Ota; S Kotani; Mitsuyoshi Nakao; Y Takami; S Takeda; Hideyuki Saya
Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells.
The EMBO journal 2001;20(22):6499-508.
2001: Kenji Tada; Shoji Shiraishi; Takanori Kamiryo; Md. Kaimul Ahsan; H Hirano; Jun-ichi Kuratsu; Masato Kochi; Hideyuki Saya; Yukitaka Ushio
Analysis of loss of heterozygosity on chromosome 10 in patients with malignant astrocytic tumors: correlation with patient age and survival.
Journal of neurosurgery 2001;95(4):651-9.
2001: T Kino; Hideo Takeshima; Mitsuyoshi Nakao; Toru Nishi; Kenichiro Yamamoto; T Kimura; Y Saito; Masato Kochi; Jun-ichi Kuratsu; Hideyuki Saya; Yukitaka Ushio
Identification of the cis-acting region in the NF2 gene promoter as a potential target for mutation and methylation-dependent silencing in schwannoma.
Genes to cells : devoted to molecular & cellular mechanisms 2001;6(5):441-54.
2001: Hiroshi Tokuo; Shunji Yunoue; Liping Feng; M Kimoto; H Tsuji; Tomomichi Ono; Hideyuki Saya; Norie Araki
Phosphorylation of neurofibromin by cAMP-dependent protein kinase is regulated via a cellular association of N(G),N(G)-dimethylarginine dimethylaminohydrolase.
FEBS letters 2001;494(1-2):48-53.
2001: Hiromasa Tsuiki; Masayuki Nitta; M Tada; Masaki Inagaki; Yukitaka Ushio; Hideyuki Saya
Mechanism of hyperploid cell formation induced by microtubule inhibiting drug in glioma cell lines.
Oncogene 2001;20(4):420-9.
2000: Yoshiaki Kawano; Isamu Okamoto; Daizo Murakami; H Itoh; Masahiro Yoshida; S Ueda; Hideyuki Saya
Ras oncoprotein induces CD44 cleavage through phosphoinositide 3-OH kinase and the rho family of small G proteins.
The Journal of biological chemistry 2000;275(38):29628-35.
2000: Naoyuki Fujita; N Shimotake; ohki izuru; Tsutomu Chiba; Hideyuki Saya; Masahiro Shirakawa; Mitsuyoshi Nakao
Mechanism of transcriptional regulation by methyl-CpG binding protein MBD1.
Molecular and cellular biology 2000;20(14):5107-18.
2000: Toru Hirota; Tetsuro Morisaki; Yasuyuki Nishiyama; Tomotoshi Marumoto; K Tada; Toshihiro Hara; N Masuko; Masaki Inagaki; Katsuyoshi Hatakeyama; Hideyuki Saya
Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor.
The Journal of cell biology 2000;149(5):1073-86.
2000: N Hanada; K Makino; H Koga; Tetsuro Morisaki; H Kuwahara; N Masuko; Yoichi Tabira; T Hiraoka; N Kitamura; A Kikuchi; Hideyuki Saya
NE-dlg, a mammalian homolog of Drosophila dlg tumor suppressor, induces growth suppression and impairment of cell adhesion: possible involvement of down-regulation of beta-catenin by NE-dlg expression.
International journal of cancer. Journal international du cancer 2000;86(4):480-8.
2000: Norie Araki; T Morimasa; T Sakai; H Tokuoh; Shunji Yunoue; Masayuki Kamo; K Miyazaki; K Abe; Hideyuki Saya; Akira Tsugita
Comparative analysis of brain proteins from p53-deficient mice by two-dimensional electrophoresis.
Electrophoresis 2000;21(9):1880-9.
2000: A Obata; Masao Eura; J Sasaki; Hideyuki Saya; Kazuaki Chikamatsu; M Tada; R D Iggo; Eiji Yumoto
Clinical significance of p53 functional loss in squamous cell carcinoma of the oropharynx.
International journal of cancer. Journal international du cancer 2000;89(2):187-93.
2000: Toru Nishi; K Yoshizato; T Goto; H Takeshima; S Yamashiro; Jun-ichi Kuratsu; Hideyuki Saya; Yukitaka Ushio
Reporter/Functional gene transfer in rat brain.
Methods in molecular medicine 2000;37():339-48.
1999: Hiromasa Tsuiki; Masayuki Nitta; Akiko Furuya; Nobuo Hanai; T Fujiwara; Masaki Inagaki; Masato Kochi; Yukitaka Ushio; Hideyuki Saya; Md. Kaimul Ahsan
A novel human nucleoside diphosphate (NDP) kinase, Nm23-H6, localizes in mitochondria and affects cytokinesis.
Journal of cellular biochemistry 1999;76(2):254-69.
1999: K Ito; Isamu Okamoto; N Araki; Yoshiaki Kawano; Mitsuyoshi Nakao; S Fujiyama; K Tomita; Tatsuyuki Mimori; Hideyuki Saya
Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts.
Oncogene 1999;18(50):7080-90.
1999: H Kuwahara; Norie Araki; K Makino; N Masuko; Shinobu Honda; K Kaibuchi; Kohji Fukunaga; Eishichi Miyamoto; Michio Ogawa; Hideyuki Saya
A novel NE-dlg/SAP102-associated protein, p51-nedasin, related to the amidohydrolase superfamily, interferes with the association between NE-dlg/SAP102 and N-methyl-D-aspartate receptor.
The Journal of biological chemistry 1999;274(45):32204-14.
1999: Yasushi Nagata; Tadashi Anan; T Yoshida; T Mizukami; Y Taya; Toshiyoshi Fujiwara; H Kato; Hideyuki Saya; Mitsuyoshi Nakao
The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 association.
Oncogene 1999;18(44):6037-49.
1999: Yasuyuki Nishiyama; Toru Hirota; Tetsuro Morisaki; Toshihiro Hara; Tomotoshi Marumoto; S Iida; K Makino; H Yamamoto; Takehisa Hiraoka; N Kitamura; Hideyuki Saya
A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis.
FEBS letters 1999;459(2):159-65.
1999: Isamu Okamoto; Yoshiaki Kawano; Mitsuhiro Matsumoto; Moritaka Suga; K Kaibuchi; Masayuki Ando; Hideyuki Saya
Regulated CD44 cleavage under the control of protein kinase C, calcium influx, and the Rho family of small G proteins.
The Journal of biological chemistry 1999;274(36):25525-34.
1999: Naoyuki Fujita; S Takebayashi; K Okumura; S Kudo; Tsutomu Chiba; Hideyuki Saya; Mitsuyoshi Nakao
Methylation-mediated transcriptional silencing in euchromatin by methyl-CpG binding protein MBD1 isoforms.
Molecular and cellular biology 1999;19(9):6415-26.
1999: H Koga; S Matsui; Toru Hirota; S Takebayashi; K Okumura; Hideyuki Saya
A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes.
Oncogene 1999;18(26):3799-809.
1999: N Masuko; K Makino; H Kuwahara; Kohji Fukunaga; T Sudo; Norie Araki; Hideyuki Yamamoto; Y Yamada; Eishichi Miyamoto; Hideyuki Saya
Interaction of NE-dlg/SAP102, a neuronal and endocrine tissue-specific membrane-associated guanylate kinase protein, with calmodulin and PSD-95/SAP90. A possible regulatory role in molecular clustering at synaptic sites.
The Journal of biological chemistry 1999;274(9):5782-90.
1999: Isamu Okamoto; Yoshiaki Kawano; Hiromasa Tsuiki; Ji-ichiro Sasaki; Mitsuyoshi Nakao; Mitsuhiro Matsumoto; Moritaka Suga; Masayuki Ando; M Nakajima; Hideyuki Saya
CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration.
Oncogene 1999;18(7):1435-46.
1999: N Araki; Hideyuki Saya
[Cellular signal transduction via the neurofibromatosis type 2 tumor suppressor gene product; merlin].
Seikagaku. The Journal of Japanese Biochemical Society 1999;71(2):128-34.
1999: N Mugita; Y Honda; H Nakamura; T Fujiwara; K Tanaka; S Omura; N Shimbara; Michio Ogawa; Hideyuki Saya; Mitsuyoshi Nakao
The involvement of proteasome in myogenic differentiation of murine myocytes and human rhabdomyosarcoma cells.
International journal of molecular medicine 1999;3(2):127-37.
1998: H Miyake; Isamu Okamoto; I Hara; K Gohji; K Yamanaka; S Arakawa; S Kamidono; Hideyuki Saya
Highly specific and sensitive detection of malignancy in urine samples from patients with urothelial cancer by CD44v8-10/CD44v10 competitive RT-PCR.
International journal of cancer. Journal international du cancer 1998;79(6):560-4.
1998: Tadashi Anan; Yasushi Nagata; H Koga; Yoshiomi Honda; N Yabuki; C Miyamoto; A Kuwano; I Matsuda; Fumio Endo; Hideyuki Saya; Mitsuyoshi Nakao
Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes.
Genes to cells : devoted to molecular & cellular mechanisms 1998;3(11):751-63.
1998: H Koga; N Araki; Hideo Takeshima; Toru Nishi; Toru Hirota; Y Kimura; Mitsuyoshi Nakao; Hideyuki Saya
Impairment of cell adhesion by expression of the mutant neurofibromatosis type 2 (NF2) genes which lack exons in the ERM-homology domain.
Oncogene 1998;17(7):801-10.
1998: Md. Kaimul Ahsan; T Sudo; Hiromasa Tsuiki; H Miyake; Tetsuro Morisaki; Ji-ichiro Sasaki; N Masuko; Masato Kochi; Yukitaka Ushio; Hideyuki Saya
Identification of a novel human homolog of the Drosophila dlg, P-dlg, specifically expressed in the gland tissues and interacting with p55.
FEBS letters 1998;433(1-2):63-7.
1998: Y Kimura; H Koga; N Araki; N Mugita; N Fujita; Hideo Takeshima; Toru Nishi; T Yamashima; T C Saido; T Yamasaki; K Moritake; Hideyuki Saya; Mitsuyoshi Nakao
The involvement of calpain-dependent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas.
Nature medicine 1998;4(8):915-22.
1998: Hideo Takeshima; Toru Nishi; Kenichiro Yamamoto; T Kino; H Nakamura; Hideyuki Saya; Masato Kochi; Jun-ichi Kuratsu; Yukitaka Ushio
Loss of merlin-p85 protein complex in NF2-related tumors.
International journal of oncology 1998;12(5):1073-8.
1998: Ji-ichiro Sasaki; K K Tanabe; K Takahashi; Isamu Okamoto; H Fujimoto; Mitsuhiro Matsumoto; Moritaka Suga; Masayuki Ando; Hideyuki Saya
Expression of CD44 splicing isoforms in lung cancers: dominant expression of CD44v8-10 in non-small cell lung carcinomas.
International journal of oncology 1998;12(3):525-33.
1998: Md. Kaimul Ahsan; M Yoshida; Hiromasa Tsuiki; K Ito; M Ueno; Mitsuyoshi Nakao; K Oka; M Tada; Masato Kochi; Jun-ichi Kuratsu; Yukitaka Ushio; Hideyuki Saya
Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region.
Oncogene 1998;16(8):1009-19.
1998: H Miyake; N Hanada; Md. Kaimul Ahsan; S Kagawa; Toshiyoshi Fujiwara; I Hara; H Eto; K Gohji; S Arakawa; S Kamidono; Hideyuki Saya
Overexpression of Bcl-2 in bladder cancer cells inhibits apoptosis induced by cisplatin and adenoviral-mediated p53 gene transfer.
Oncogene 1998;16(7):933-43.
1998: Isamu Okamoto; T Morisaki; Ji-ichiro Sasaki; H Miyake; Mitsuhiro Matsumoto; Moritaka Suga; Masayuki Ando; Hideyuki Saya
Molecular detection of cancer cells by competitive reverse transcription-polymerase chain reaction analysis of specific CD44 variant RNAs.
Journal of the National Cancer Institute 1998;90(4):307-15.
1997: N Mugita; Y Kimura; Michio Ogawa; Hideyuki Saya; Mitsuyoshi Nakao
Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene.
Biochemical and biophysical research communications 1997;239(3):845-50.
1997: N Araki; Hideo Takeshima; Hideyuki Saya
[Neurofibromatosis type 2 (NF2)].
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(11):1427-31.
1997: K Makino; H Kuwahara; N Masuko; Yasuyuki Nishiyama; Tetsuro Morisaki; Ji-ichiro Sasaki; Mitsuyoshi Nakao; A Kuwano; M Nakata; Yukitaka Ushio; Hideyuki Saya
Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein.
Oncogene 1997;14(20):2425-33.