Mohamed Sayegh

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De Serres Sacha A; Sayegh Mohamed H; Najafian Nader
Immunosuppressive drugs and Tregs: a critical evaluation!
Yeung M Y; Sayegh M H
Regulatory T cells in transplantation: what we know and what we do not know.
Fiorina Paolo; Jurewicz Mollie; Augello Andrea; Vergani Andrea; Dada Shirine; La Rosa Stefano; Selig Martin; Godwin Jonathan; Law Kenneth; Placidi Claudia; Smith R Neal; Capella Carlo; Rodig Scott; Adra Chaker N; Atkinson Mark; Sayegh Mohamed H; Abdi Reza
Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes.

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All Publications

2009: De Serres Sacha A; Sayegh Mohamed H; Najafian Nader
Immunosuppressive drugs and Tregs: a critical evaluation!
Clinical journal of the American Society of Nephrology : CJASN 2009;4(10):1661-9.
2009: Yeung M Y; Sayegh M H
Regulatory T cells in transplantation: what we know and what we do not know.
Transplantation proceedings 2009;41(6 Suppl):S21-6.
2009: Fiorina Paolo; Jurewicz Mollie; Augello Andrea; Vergani Andrea; Dada Shirine; La Rosa Stefano; Selig Martin; Godwin Jonathan; Law Kenneth; Placidi Claudia; Smith R Neal; Capella Carlo; Rodig Scott; Adra Chaker N; Atkinson Mark; Sayegh Mohamed H; Abdi Reza
Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):993-1004.
2009: Yuan Xueli; Ansari M Javeed; D'Addio Francesca; Paez-Cortez Jesus; Schmitt Isabella; Donnarumma Michela; Boenisch Olaf; Zhao Xiaozhi; Popoola Joyce; Clarkson Michael R; Yagita Hideo; Akiba Hisaya; Freeman Gordon J; Iacomini John; Turka Laurence A; Glimcher Laurie H; Sayegh Mohamed H
Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(26):10734-9.
2009: Li Xian C; Rothstein David M; Sayegh Mohamed H
Costimulatory pathways in transplantation: challenges and new developments.
Immunological reviews 2009;229(1):271-93.
2009: Sayegh Mohamed H
Looking into the crystal ball: kidney transplantation in 2025.
Nature clinical practice. Nephrology 2009;5(3):117.
2008: Fiorina Paolo; Vergani Andrea; Dada Shirine; Jurewicz Mollie; Wong Masie; Law Kenneth; Wu Erxi; Tian Ze; Abdi Reza; Guleria Indira; Rodig Scott; Dunussi-Joannopoulos Kyri; Bluestone Jeffrey; Sayegh Mohamed H
Targeting CD22 reprograms B-cells and reverses autoimmune diabetes.
Diabetes 2008;57(11):3013-24.
2008: Womer Karl L; Magee Colm C; Najafian Nader; Vella John P; Milford Edgar L; Sayegh Mohamed H; Carpenter Charles B
A pilot study on the immunological effects of oral administration of donor major histocompatibility complex class II peptides in renal transplant recipients.
Clinical transplantation 2008;22(6):754-9.
2008: Ansari M Javeed; Sayegh Mohamed H
Complement dances with T cells.
Blood 2008;112(5):1551-2.
2008: Boenisch Olaf; Sayegh Mohamed H; Najafian Nader
Negative T-cell costimulatory pathways: their role in regulating alloimmune responses.
Current opinion in organ transplantation 2008;13(4):373-8.
2008: Porrett Paige M; Yuan Xueli; LaRosa David F; Walsh Patrick T; Yang Jaeseok; Gao Wenda; Li Peiying; Zhang Jidong; Ansari Javeed M; Hancock Wayne W; Sayegh Mohamed H; Koulmanda Maria; Strom Terry B; Turka Laurence A
Mechanisms underlying blockade of allograft acceptance by TLR ligands.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):1692-9.
2008: Elyaman Wassim; Kivisäkk Pia; Reddy Jay; Chitnis Tanuja; Raddassi Khadir; Imitola Jaime; Bradshaw Elizabeth; Kuchroo Vijay K; Yagita Hideo; Sayegh Mohamed H; Khoury Samia J
Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitis.
The American journal of pathology 2008;173(2):411-22.
2008: Wang Li; Pino-Lagos Karina; de Vries Victor C; Guleria Indira; Sayegh Mohamed H; Noelle Randolph J
Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(27):9331-6.
2008: Abdi Reza; Fiorina Paolo; Adra Chaker N; Atkinson Mark; Sayegh Mohamed H
Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes.
Diabetes 2008;57(7):1759-67.
2008: Tian Chaorui; Yuan Xueli; Bagley Jessamyn; Blazar Bruce R; Sayegh Mohamed H; Iacomini John
Induction of transplantation tolerance by combining non-myeloablative conditioning with delivery of alloantigen by T cells.
Clinical immunology (Orlando, Fla.) 2008;127(2):130-7.
2008: Fiorina Paolo; Jurewicz Mollie; Vergani Andrea; Augello Andrea; Paez Jesus; Ricchiuti Vincent; Tchipachvili Vaja; Sayegh Mohamed H; Abdi Reza
Phenotypic and functional differences between wild-type and CCR2-/- dendritic cells: implications for islet transplantation.
Transplantation 2008;85(7):1030-8.
2008: Sayegh Mohamed H; Weiner Howard L
Regulating rejection with cell therapy.
Nature biotechnology 2008;26(2):191-2.
2008: Yang Jun; Popoola Joyce; Khandwala Shakila; Vadivel Nidyanandh; Vanguri Vijay; Yuan Xueli; Dada Shirine; Guleria Indira; Tian Chaorui; Ansari M Javeed; Shin Tahiro; Yagita Hideo; Azuma Miyuki; Sayegh Mohamed H; Chandraker Anil
Critical role of donor tissue expression of programmed death ligand-1 in regulating cardiac allograft rejection and vasculopathy.
Circulation 2008;117(5):660-9.
2008: Ueno Takuya; Habicht Antje; Clarkson Michael R; Albin Monica J; Yamaura Kazuhiro; Boenisch Olaf; Popoola Joyce; Wang Ying; Yagita Hideo; Akiba Hisaya; Ansari M Javeed; Yang Jaeseok; Turka Laurence A; Rothstein David M; Padera Robert F; Najafian Nader; Sayegh Mohamed H
The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model.
The Journal of clinical investigation 2008;118(2):742-51.
2008: Ansari Mohammed Javeed I; Fiorina Paolo; Dada Shirine; Guleria Indira; Ueno Takuya; Yuan Xueli; Trikudanathan Subbulaxmi; Smith R Neal; Freeman Gordon; Sayegh Mohamed H
Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice.
Clinical immunology (Orlando, Fla.) 2008;126(2):140-7.
2008: Schatton Tobias; Murphy George F; Frank Natasha Y; Yamaura Kazuhiro; Waaga-Gasser Ana Maria; Gasser Martin; Zhan Qian; Jordan Stefan; Duncan Lyn M; Weishaupt Carsten; Fuhlbrigge Robert C; Kupper Thomas S; Sayegh Mohamed H; Frank Markus H
Identification of cells initiating human melanomas.
Nature 2008;451(7176):345-9.
2008: Popoola Joyce; Sayegh Mohamed H
Harnessing negative T-cell costimulatory pathways to promote engraftment.
Transplant international : official journal of the European Society for Organ Transplantation 2008;21(1):18-20.
2007: Yang Jaeseok; Brook Matthew O; Carvalho-Gaspar Manuela; Zhang Jidong; Ramon Hilda E; Sayegh Mohamed H; Wood Kathryn J; Turka Laurence A; Jones Nick D
Allograft rejection mediated by memory T cells is resistant to regulation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):19954-9.
2007: Habicht A; Kewalaramani R; Vu M D; Demirci G; Blazar B R; Sayegh M H; Li X C
Striking dichotomy of PD-L1 and PD-L2 pathways in regulating alloreactive CD4(+) and CD8(+) T cells in vivo.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(12):2683-92.
2007: Tian Chaorui; Ansari Mohammed Javeed I; Paez-Cortez Jesus; Bagley Jessamyn; Godwin Jonathan; Donnarumma Michela; Sayegh Mohamed H; Iacomini John
Induction of robust diabetes resistance and prevention of recurrent type 1 diabetes following islet transplantation by gene therapy.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6762-9.
2007: Habicht Antje; Dada Shirine; Jurewicz Mollie; Fife Brian T; Yagita Hideo; Azuma Miyuki; Sayegh Mohamed H; Guleria Indira
A link between PDL1 and T regulatory cells in fetomaternal tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(8):5211-9.
2007: Tanaka Katsunori; Albin Monica J; Yuan Xueli; Yamaura Kazuhiro; Habicht Antje; Murayama Takaya; Grimm Martin; Waaga Ana Maria; Ueno Takuya; Padera Robert F; Yagita Hideo; Azuma Miyuki; Shin Tahiro; Blazar Bruce R; Rothstein David M; Sayegh Mohamed H; Najafian Nader
PDL1 is required for peripheral transplantation tolerance and protection from chronic allograft rejection.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(8):5204-10.
2007: Guleria Indira; Gubbels Bupp Melanie; Dada Shirine; Fife Brian; Tang Qizhi; Ansari Mohammed Javeed; Trikudanathan Subbulaxmi; Vadivel Nidyanandh; Fiorina Paolo; Yagita Hideo; Azuma Miyuki; Atkinson Mark; Bluestone Jeffrey A; Sayegh Mohamed H
Mechanisms of PDL1-mediated regulation of autoimmune diabetes.
Clinical immunology (Orlando, Fla.) 2007;125(1):16-25.
2007: Trikudanathan S; Sayegh M H
The evolution of the immunobiology of co-stimulatory pathways: clinical implications.
Clinical and experimental rheumatology 2007;25(5 Suppl 46):S12-21.
2007: Ansari M Javeed; Sayegh Mohamed H
The arduous road to achieving an immunosuppression-free state in kidney transplant recipients.
Nature clinical practice. Nephrology 2007;3(9):464-5.
2007: Zeisberg Elisabeth M; Tarnavski Oleg; Zeisberg Michael; Dorfman Adam L; McMullen Julie R; Gustafsson Erika; Chandraker Anil; Yuan Xueli; Pu William T; Roberts Anita B; Neilson Eric G; Sayegh Mohamed H; Izumo Seigo; Kalluri Raghu
Endothelial-to-mesenchymal transition contributes to cardiac fibrosis.
Nature medicine 2007;13(8):952-61.
2007: Habicht A; Najafian N; Yagita H; Sayegh M H; Clarkson M R
New insights in CD28-independent allograft rejection.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(8):1917-26.
2007: Izawa Atsushi; Yamaura Kazuhiro; Albin Monica J; Jurewicz Mollie; Tanaka Katsunori; Clarkson Michael R; Ueno Takuya; Habicht Antje; Freeman Gordon J; Yagita Hideo; Abdi Reza; Pearson Todd; Greiner Dale L; Sayegh Mohamed H; Najafian Nader
A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):786-96.
2007: Xiao Sheng; Najafian Nader; Reddy Jay; Albin Monica; Zhu Chen; Jensen Eric; Imitola Jaime; Korn Thomas; Anderson Ana C; Zhang Zheng; Gutierrez Cristina; Moll Thomas; Sobel Raymond A; Umetsu Dale T; Yagita Hideo; Akiba Hisaya; Strom Terry; Sayegh Mohamed H; DeKruyff Rosemarie H; Khoury Samia J; Kuchroo Vijay K
Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.
The Journal of experimental medicine 2007;204(7):1691-702.
2007: Sayegh Mohamed H; Remuzzi Giuseppe
Clinical update: immunosuppression minimisation.
Lancet 2007;369(9574):1676-8.
2007: Salama Alan D; Womer Karl L; Sayegh Mohamed H
Clinical transplantation tolerance: many rivers to cross.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5419-23.
2007: Lacy-Hulbert A; Ueno T; Ito T; Jurewicz M; Izawa A; Smith R N; Chase C M; Tanaka K; Fiorina P; Russell P S; Auchincloss H; Sayegh M H; Hynes R O; Abdi R
Beta 3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(5):1080-90.
2007: Methe Heiko; Groothuis Adam; Sayegh Mohamed H; Edelman Elazer R
Matrix adherence of endothelial cells attenuates immune reactivity: induction of hyporesponsiveness in allo- and xenogeneic models.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(7):1515-26.
2007: Fiorina Paolo; Jurewicz Mollie; Tanaka Katsunori; Behazin Negin; Augello Andrea; Vergani Andrea; von Andrian Ulrich H; Smith Neal R; Sayegh Mohamed H; Abdi Reza
Characterization of donor dendritic cells and enhancement of dendritic cell efflux with CC-chemokine ligand 21: a novel strategy to prolong islet allograft survival.
Diabetes 2007;56(4):912-20.
2007: Guleria Indira; Sayegh Mohamed H
Maternal acceptance of the fetus: true human tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3345-51.
2007: St Clair E William; Turka Larry A; Saxon Andrew; Matthews Jeffrey B; Sayegh Mohamed H; Eisenbarth George S; Bluestone Jeffrey
New reagents on the horizon for immune tolerance.
Annual review of medicine 2007;58():329-46.
2006: Pendse S S; Behjati S; Schatton T; Izawa A; Sayegh M H; Frank M H
P-glycoprotein functions as a differentiation switch in antigen presenting cell maturation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(12):2884-93.
2006: Fife Brian T; Guleria Indira; Gubbels Bupp Melanie; Eagar Todd N; Tang Qizhi; Bour-Jordan Helene; Yagita Hideo; Azuma Miyuki; Sayegh Mohamed H; Bluestone Jeffrey A
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.
The Journal of experimental medicine 2006;203(12):2737-47.
2006: Lopez Marta; Clarkson Michael R; Albin Monica; Sayegh Mohamed H; Najafian Nader
A novel mechanism of action for anti-thymocyte globulin: induction of CD4+CD25+Foxp3+ regulatory T cells.
Journal of the American Society of Nephrology : JASN 2006;17(10):2844-53.
2006: Ansari Mohammed Javeed; Sayegh Mohamed H
Costimulation couture: a designer approach to regulating autoimmunity.
The Journal of clinical investigation 2006;116(8):2080-3.
2006: Ansari Mohammed Javeed; Sayegh Mohamed H
Switching immunosuppressive drugs in kidney transplant recipients: "show me the evidence".
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 2006;17(2):149-52.
2006: Harmon William; Meyers Kevin; Ingelfinger Julie; McDonald Ruth; McIntosh Matthew; Ho Martin; Spaneas Leslie; Palmer Jo Ann; Hawk Marena; Geehan Chris; Tinckam Kathryn; Hancock Wayne W; Sayegh Mohamed H
Safety and efficacy of a calcineurin inhibitor avoidance regimen in pediatric renal transplantation.
Journal of the American Society of Nephrology : JASN 2006;17(6):1735-45.
2006: Beaudette-Zlatanova B C; Whalen B; Zipris D; Yagita H; Rozing J; Groen H; Benjamin C D; Hunig T; Drexhage H A; Ansari M J; Leif J; Mordes J P; Greiner D L; Sayegh M H; Rossini A A
Costimulation and autoimmune diabetes in BB rats.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(5 Pt 1):894-902.
2006: Keir Mary E; Liang Spencer C; Guleria Indira; Latchman Yvette E; Qipo Andi; Albacker Lee A; Koulmanda Maria; Freeman Gordon J; Sayegh Mohamed H; Sharpe Arlene H
Tissue expression of PD-L1 mediates peripheral T cell tolerance.
The Journal of experimental medicine 2006;203(4):883-95.
2006: Neujahr David C; Chen Chuangqi; Huang Xiaolun; Markmann James F; Cobbold Stephen; Waldmann Herman; Sayegh Mohamed H; Hancock Wayne W; Turka Laurence A
Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4632-9.
2006: Lee Kyung-Mi; Forman John P; McNerney Megan E; Stepp Susan; Kuppireddi Sumalatha; Guzior Dustin; Latchman Yvette E; Sayegh Mohamed H; Yagita Hideo; Park Chul-Kyu; Oh Seog Bae; Wülfing Christoph; Schatzle John; Mathew Porunelloor A; Sharpe Arlene H; Kumar Vinay
Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions.
Blood 2006;107(8):3181-8.
2006: Sayegh Mohamed H; Chandraker Anil
Does belatacept provide equivalent suppression of acute renal transplant rejection to ciclosporin?
Nature clinical practice. Nephrology 2006;2(3):134-5.
2006: Zhu Bing; Guleria Indira; Khosroshahi Arezou; Chitnis Tanuja; Imitola Jaime; Azuma Miyuki; Yagita Hideo; Sayegh Mohamed H; Khoury Samia J
Differential role of programmed death-ligand 1 [corrected] and programmed death-ligand 2 [corrected] in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(6):3480-9.
2006: Fiorina Paolo; Ansari Mohammed Javeed; Jurewicz Mollie; Barry Mark; Ricchiuti Vincent; Smith Rex Neal; Shea Susan; Means Terry K; Auchincloss Hugh; Luster Andrew D; Sayegh Mohamed H; Abdi Reza
Role of CXC chemokine receptor 3 pathway in renal ischemic injury.
Journal of the American Society of Nephrology : JASN 2006;17(3):716-23.
2006: Vu Minh Diem; Clarkson Michael R; Yagita Hideo; Turka Laurence A; Sayegh Mohamed H; Li Xian Chang
Critical, but conditional, role of OX40 in memory T cell-mediated rejection.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1394-401.
2006: Iacomini John; Sayegh Mohamed H
Measuring T cell alloreactivity to predict kidney transplant outcomes: are we there yet?
Journal of the American Society of Nephrology : JASN 2006;17(2):328-30.
2006: Sánchez-Fueyo Alberto; Sandner Sigrid; Habicht Antje; Mariat Christophe; Kenny James; Degauque Nicolas; Zheng Xin Xiao; Strom Terry B; Turka Laurence A; Sayegh Mohamed H
Specificity of CD4+CD25+ regulatory T cell function in alloimmunity.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):329-34.
2006: Habicht Antje; Clarkson Michael R; Yang Jun; Henderson Joel; Brinkmann Volker; Fernandes Stacey; Jurewicz Mollie; Yuan Xueli; Sayegh Mohamed H
Novel insights into the mechanism of action of FTY720 in a transgenic model of allograft rejection: implications for therapy of chronic rejection.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):36-42.
2005: Hoerbelt Ruediger; Johnston Douglas R; Shoji Tsuyoshi; Houser Stuart L; Hasse Rebecca S; Ledgerwood Levi G; Iribarne Alexander; Allan James S; Sayegh Mohamed H; Sachs David H; Madsen Joren C
Combination treatment with donor-specific transfusions and cyclosporine a induces long-term survival of cardiac allografts in miniature Swine.
Transplantation 2005;80(9):1275-82.
2005: Ruiz-Perez Begonia; Chung Doo R; Sharpe Arlene H; Yagita Hideo; Kalka-Moll Wiltrud M; Sayegh Mohamed H; Kasper Dennis L; Tzianabos Arthur O
Modulation of surgical fibrosis by microbial zwitterionic polysaccharides.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(46):16753-8.
2005: Clarkson Michael R; Sayegh Mohamed H
T-cell costimulatory pathways in allograft rejection and tolerance.
Transplantation 2005;80(5):555-63.
2005: Sho Masayuki; Kishimoto Koji; Harada Hiroshi; Livak Mauren; Sanchez-Fueyo Alberto; Yamada Akira; Zheng Xin Xiao; Strom Terry B; Basadonna Giacomo P; Sayegh Mohamed H; Rothstein David M
Requirements for induction and maintenance of peripheral tolerance in stringent allograft models.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(37):13230-5.
2005: Methe Heiko; Nugent Helen M; Groothuis Adam; Seifert Philip; Sayegh Mohamed H; Edelman Elazer R
Matrix embedding alters the immune response against endothelial cells in vitro and in vivo.
Circulation 2005;112(9 Suppl):I89-95.
2005: Guleria Indira; Khosroshahi Arezou; Ansari Mohammed Javeed; Habicht Antje; Azuma Miyuki; Yagita Hideo; Noelle Randolph J; Coyle Anthony; Mellor Andrew L; Khoury Samia J; Sayegh Mohamed H
A critical role for the programmed death ligand 1 in fetomaternal tolerance.
The Journal of experimental medicine 2005;202(2):231-7.
2005: Shoji Tsuyoshi; Wain John C; Houser Stuart L; Benjamin Louis C; Johnston Douglas R; Hoerbelt Ruediger; Hasse Rebecca S; Lee Richard S; Muniappan Ashok; Guenther Dax A; Bravard Marjory A; Ledgerwood Levi G; Sachs David H; Sayegh Mohamed H; Madsen Joren C; Allan James S
Indirect recognition of MHC class I allopeptides accelerates lung allograft rejection in miniature swine.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(7):1626-34.
2005: Ito Toshiro; Ueno Takuya; Clarkson Michael R; Yuan Xueli; Jurewicz Mollie M; Yagita Hideo; Azuma Miyuki; Sharpe Arlene H; Auchincloss Hugh; Sayegh Mohamed H; Najafian Nader
Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):6648-56.
2005: Frank Natasha Y; Margaryan Armen; Huang Ying; Schatton Tobias; Waaga-Gasser Ana Maria; Gasser Martin; Sayegh Mohamed H; Sadee Wolfgang; Frank Markus H
ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma.
Cancer research 2005;65(10):4320-33.
2005: Kashizuka Hisanori; Sho Masayuki; Nomi Takeo; Ikeda Naoya; Kuzumoto Yukiyasu; Akashi Satoru; Tsurui Yoshikazu; Mizuno Takashi; Kanehiro Hiromichi; Yagita Hideo; Nakajima Yoshiyuki; Sayegh Mohamed H
Role of the ICOS-B7h costimulatory pathway in the pathophysiology of chronic allograft rejection.
Transplantation 2005;79(9):1045-50.
2005: Schenk Soren; Kish Danielle D; He Chunshui; El-Sawy Tarek; Chiffoleau Eise; Chen Chuangqi; Wu Zihao; Sandner Sigrid; Gorbachev Anton V; Fukamachi Kiyotaka; Heeger Peter S; Sayegh Mohamed H; Turka Laurence A; Fairchild Robert L
Alloreactive T cell responses and acute rejection of single class II MHC-disparate heart allografts are under strict regulation by CD4+ CD25+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3741-8.
2005: Sandner Sigrid E; Clarkson Michael R; Salama Alan D; Sanchez-Fueyo Alberto; Domenig Christoph; Habicht Antje; Najafian Nader; Yagita Hideo; Azuma Miyuki; Turka Laurence A; Sayegh Mohamed H
Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3408-15.
2005: Kutok Jeffery L; Yang Xing; Folkerth Rebecca D; Imitola Jaime; Raddassi Khadir; Yano Yoshihiko; Salahuddin Saira; Lawitts Joel; Imboden Hans; Chinami Masanobu; Shirakawa Taro; Turner Helen; Khoury Samia; Sayegh Mohamed H; Scadden David; Adra Chaker
The cell cycle associated protein, HTm4, is expressed in differentiating cells of the hematopoietic and central nervous system in mice.
Journal of molecular histology 2005;36(1-2):77-87.
2005: Tinckam Kathryn J; Sayegh Mohamed H
Transplantation tolerance in pediatric recipients: lessons and challenges.
Pediatric transplantation 2005;9(1):17-27.
2005: Yamada Akira; Salama Alan D; Sho Masayuki; Najafian Nader; Ito Toshiro; Forman John P; Kewalramani Reshma; Sandner Sigrid; Harada Hiroshi; Clarkson Michael R; Mandelbrot Didier A; Sharpe Arlene H; Oshima Hideo; Yagita Hideo; Chalasani Geetha; Lakkis Fadi G; Auchincloss Hugh; Sayegh Mohamed H
CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1357-64.
2005: Sandner Sigrid E; Clarkson Michael R; Salama Alan D; Sanchez-Fueyo Alberto; Yagita Hideo; Turka Laurence A; Sayegh Mohamed H
Mechanisms of tolerance induced by donor-specific transfusion and ICOS-B7h blockade in a model of CD4+ T-cell-mediated allograft rejection.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(1):31-9.
2005: Sayegh Mohamed H; Perico Norberto; Remuzzi Giuseppe
Transplantation tolerance. A complex scenario awaiting clinical applicability.
Contributions to nephrology 2005;146():95-104.
2004: Sayegh Mohamed H; Carpenter Charles B
Transplantation 50 years later--progress, challenges, and promises.
The New England journal of medicine 2004;351(26):2761-6.
2004: Perico Norberto; Cattaneo Dario; Sayegh Mohamed H; Remuzzi Giuseppe
Delayed graft function in kidney transplantation.
Lancet 2004;364(9447):1814-27.
2004: Denton Mark D; Magee Colm; Melter Michael; Dharnidharka Vikas R; Sayegh Mohamed H; Briscoe David M
TNP-470, an angiogenesis inhibitor, attenuates the development of allograft vasculopathy.
Transplantation 2004;78(8):1218-21.
2004: Kishimoto Koji; Yuan Xueli; Auchincloss Hugh; Sharpe Arlene H; Mandelbrot Didier A; Sayegh Mohamed H
Mechanism of action of donor-specific transfusion in inducing tolerance: role of donor MHC molecules, donor co-stimulatory molecules, and indirect antigen presentation.
Journal of the American Society of Nephrology : JASN 2004;15(9):2423-8.
2004: Magee Colm C; Denton Mark D; Womer Karl L; Khoury Samia J; Sayegh Mohamed H
Assessment by flow cytometry of intracellular cytokine production in the peripheral blood cells of renal transplant recipients.
Clinical transplantation 2004;18(4):395-401.
2004: Poggio Emilio D; Clemente Michael; Riley Jocelyn; Roddy Meagan; Greenspan Neil S; Dejelo Cora; Najafian Nader; Sayegh Mohamed H; Hricik Donald E; Heeger Peter S
Alloreactivity in renal transplant recipients with and without chronic allograft nephropathy.
Journal of the American Society of Nephrology : JASN 2004;15(7):1952-60.
2004: Vu Minh Diem; Amanullah Farhana; Li Yongsheng; Demirci Gulcin; Sayegh Mohamed H; Li Xian Chang
Different costimulatory and growth factor requirements for CD4+ and CD8+ T cell-mediated rejection.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):214-21.
2004: Khoury Samia J; Sayegh Mohamed H
The roles of the new negative T cell costimulatory pathways in regulating autoimmunity.
Immunity 2004;20(5):529-38.
2004: Frank Markus H; Sayegh Mohamed H
Immunomodulatory functions of mesenchymal stem cells.
Lancet 2004;363(9419):1411-2.
2004: Imitola Jaime; Comabella Manuel; Chandraker Anil K; Dangond Fernando; Sayegh Mohamed H; Snyder Evan Y; Khoury Samia J
Neural stem/progenitor cells express costimulatory molecules that are differentially regulated by inflammatory and apoptotic stimuli.
The American journal of pathology 2004;164(5):1615-25.
2004: Sayegh Mohamed H; Platt Jeffrey L
Overview: future approaches to renal replacement and regeneration.
Journal of the American Society of Nephrology : JASN 2004;15(5):1105.
2004: Holsti Matthew A; Chitnis Tanuja; Panzo Ronald J; Bronson Roderick T; Yagita Hideo; Sayegh Mohamed H; Tzianabos Arthur O
Regulation of postsurgical fibrosis by the programmed death-1 inhibitory pathway.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(9):5774-81.
2004: Ansari Mohammed Javeed I; Sayegh Mohamed H
Clinical transplantation tolerance: the promise and challenges.
Kidney international 2004;65(5):1560-3.
2004: Makhlouf Leila; Grey Shane T; Dong Victor; Csizmadia Eva; Arvelo Maria B; Auchincloss Hugh; Ferran Christiane; Sayegh Mohamed H
Depleting anti-CD4 monoclonal antibody cures new-onset diabetes, prevents recurrent autoimmune diabetes, and delays allograft rejection in nonobese diabetic mice.
Transplantation 2004;77(7):990-7.
2004: Womer Karl L; Sayegh Mohamed H
Donor antigen and transplant tolerance strategies: it takes two to tango!
Journal of the American Society of Nephrology : JASN 2004;15(4):1101-3.
2004: Chitnis Tanuja; Salama Alan D; Grusby Michael J; Sayegh Mohamed H; Khoury Samia J
Defining Th1 and Th2 immune responses in a reciprocal cytokine environment in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(7):4260-5.
2004: Izawa A; Sayegh M H; Chandraker A
The antagonism of calcineurin inhibitors and costimulatory blockers: fact or fiction?
Transplantation proceedings 2004;36(2 Suppl):570S-573S.
2004: Demirci Gülçin; Amanullah Farhana; Kewalaramani Reshma; Yagita Hideo; Strom Terry B; Sayegh Mohamed H; Li Xian Chang
Critical role of OX40 in CD28 and CD154-independent rejection.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1691-8.
2004: Abdi Reza; Means Terry K; Ito Toshiro; Smith Rex Neal; Najafian Nader; Jurewicz Mollie; Tchipachvili Vaja; Charo Israel; Auchincloss Hugh; Sayegh Mohamed H; Luster Andrew D
Differential role of CCR2 in islet and heart allograft rejection: tissue specificity of chemokine/chemokine receptor function in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):767-75.
2004: Wu Zihao; Bensinger Steven J; Zhang Jidong; Chen Chuangqi; Yuan Xueli; Huang Xiaolun; Markmann James F; Kassaee Alireza; Rosengard Bruce R; Hancock Wayne W; Sayegh Mohamed H; Turka Laurence A
Homeostatic proliferation is a barrier to transplantation tolerance.
Nature medicine 2004;10(1):87-92.
2003: Reinders Marlies E J; Sho Masayuki; Izawa Atsushi; Wang Ping; Mukhopadhyay Debabrata; Koss Kerith E; Geehan Christopher S; Luster Andrew D; Sayegh Mohamed H; Briscoe David M
Proinflammatory functions of vascular endothelial growth factor in alloimmunity.
The Journal of clinical investigation 2003;112(11):1655-65.
2003: Ariyan Charlotte; Salvalaggio Paolo; Fecteau Scott; Deng Songyan; Rogozinski Linda; Mandelbrot Didier; Sharpe Arlene; Sayegh Mohamed H; Basadonna Giacomo P; Rothstein David M
Cutting edge: transplantation tolerance through enhanced CTLA-4 expression.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):5673-7.
2003: Rothstein David M; Sayegh Mohamed H
T-cell costimulatory pathways in allograft rejection and tolerance.
Immunological reviews 2003;196():85-108.
2003: Salama Alan D; Chaudhry Afzal N; Holthaus Kathryn A; Mosley Karen; Kalluri Raghu; Sayegh Mohamed H; Lechler Robert I; Pusey Charles D; Lightstone Liz
Regulation by CD25+ lymphocytes of autoantigen-specific T-cell responses in Goodpasture's (anti-GBM) disease.
Kidney international 2003;64(5):1685-94.
2003: Frank Natasha Y; Pendse Shona S; Lapchak Peter H; Margaryan Armen; Shlain Debbie; Doeing Carsten; Sayegh Mohamed H; Frank Markus H
Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter.
The Journal of biological chemistry 2003;278(47):47156-65.
2003: Zheng Xin Xiao; Sánchez-Fueyo Alberto; Sho Masayuki; Domenig Christoph; Sayegh Mohamed H; Strom Terry B
Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance.
Immunity 2003;19(4):503-14.
2003: Najafian Nader; Chitnis Tanuja; Salama Alan D; Zhu Bing; Benou Christina; Yuan Xueli; Clarkson Michael R; Sayegh Mohamed H; Khoury Samia J
Regulatory functions of CD8+CD28- T cells in an autoimmune disease model.
The Journal of clinical investigation 2003;112(7):1037-48.
2003: Sandner Sigrid E; Salama Alan D; Houser Stuart L; Palmer Ed; Turka Laurence A; Sayegh Mohamed H
New TCR transgenic model for tracking allospecific CD4 T-cell activation and tolerance in vivo.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(10):1242-50.
2003: Lakkis Fadi G; Sayegh Mohamed H
Memory T cells: a hurdle to immunologic tolerance.
Journal of the American Society of Nephrology : JASN 2003;14(9):2402-10.
2003: Makhlouf Leila; Duvivier-Kali Valérie F; Bonner-Weir Susan; Dieperink Hans; Weir Gordon C; Sayegh Mohamed H
Importance of hyperglycemia on the primary function of allogeneic islet transplants.
Transplantation 2003;76(4):657-64.
2003: Makhlouf Leila; Yamada Akira; Ito Toshiro; Abdi Reza; Ansari Mohammed Javeed I; Khuong Chau Q; Winn Henry J; Auchincloss Hugh; Sayegh Mohamed H
Allorecognition and effector pathways of islet allograft rejection in normal versus nonobese diabetic mice.
Journal of the American Society of Nephrology : JASN 2003;14(8):2168-75.
2003: Pendse S; Sayegh M H; Frank M H
P-glycoprotein--a novel therapeutic target for immunomodulation in clinical transplantation and autoimmunity?
Current drug targets 2003;4(6):469-76.
2003: Harada Hiroshi; Salama Alan D; Sho Masayuki; Izawa Atsushi; Sandner Sigrid E; Ito Toshiro; Akiba Hisaya; Yagita Hideo; Sharpe Arlene H; Freeman Gordon J; Sayegh Mohamed H
The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity.
The Journal of clinical investigation 2003;112(2):234-43.
2003: Salama Alan D; Chitnis Tanuja; Imitola Jaime; Ansari Mohammed Javeed I; Akiba Hisaya; Tushima Fumihiko; Azuma Miyuki; Yagita Hideo; Sayegh Mohamed H; Khoury Samia J
Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis.
The Journal of experimental medicine 2003;198(1):71-8.
2003: Ansari Mohammed Javeed I; Salama Alan D; Chitnis Tanuja; Smith R Neal; Yagita Hideo; Akiba Hisaya; Yamazaki Tomohide; Azuma Miyuki; Iwai Hideyuki; Khoury Samia J; Auchincloss Hugh; Sayegh Mohamed H
The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice.
The Journal of experimental medicine 2003;198(1):63-9.
2003: Salama Alan D; Najafian Nader; Clarkson Michael R; Harmon William E; Sayegh Mohamed H
Regulatory CD25+ T cells in human kidney transplant recipients.
Journal of the American Society of Nephrology : JASN 2003;14(6):1643-51.
2003: Salama Alan D; Sayegh Mohamed H
Alternative T-cell costimulatory pathways in transplant rejection and tolerance induction: hierarchy or redundancy?
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(5):509-11.
2003: Sho Masayuki; Harada Hiroshi; Rothstein David M; Sayegh Mohamed H
CD45RB-targeting strategies for promoting long-term allograft survival and preventingchronic allograft vasculopathy.
Transplantation 2003;75(8):1142-6.
2003: Salama Alan D; Yuan Xueli; Nayer Ali; Chandraker Anil; Inobe Manabu; Uede Toshimutsu; Sayegh Mohamed H
Interaction between ICOS-B7RP1 and B7-CD28 costimulatory pathways in alloimmune responses in vivo.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(4):390-5.
2003: Sayegh Mohamed H; Wu Zihao; Hancock Wayne W; Langmuir Peter B; Mata Marielena; Sandner Sigrid; Kishimoto Koji; Sho Masayuki; Palmer Ed; Mitchell Richard N; Turka Laurence A
Allograft rejection in a new allospecific CD4+ TCR transgenic mouse.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(4):381-9.
2003: Murphy Barbara; Yu Joyce; Jiao Qingsheng; Lin Marvin; Chitnis Tanuja; Sayegh Mohamed H
A novel mechanism for the immunomodulatory functions of class II MHC-derived peptides.
Journal of the American Society of Nephrology : JASN 2003;14(4):1053-65.
2003: Sayegh Mohamed H; Colvin Robert B
Case record of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 8-2003. A 35-year-old man with early dysfunction of a second renal transplant.
The New England journal of medicine 2003;348(11):1033-44.
2003: Zhai Yuan; Meng Lingzhong; Busuttil Ronald W; Sayegh Mohamed H; Kupiec-Weglinski Jerzy W
Activation of alloreactive CD8+ T cells operates via CD4-dependent and CD4-independent mechanisms and is CD154 blockade sensitive.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):3024-8.
2003: Yuan Xueli; Salama Alan D; Dong Victor; Schmitt Isabela; Najafian Nader; Chandraker Anil; Akiba Hisaya; Yagita Hideo; Sayegh Mohamed H
The role of the CD134-CD134 ligand costimulatory pathway in alloimmune responses in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):2949-55.
2003: Chung Doo Ryeon; Kasper Dennis L; Panzo Ronald J; Chitnis Tanuja; Grusby Michael J; Sayegh Mohamed H; Tzianabos Arthur O;
CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):1958-63.
2003: Yamada Akira; Laufer Terri M; Gerth Andrea J; Chase Catharine M; Colvin Robert B; Russell Paul S; Sayegh Mohamed H; Auchincloss Hugh
Further analysis of the T-cell subsets and pathways of murine cardiac allograft rejection.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(1):23-7.
2002: Sho Masayuki; Sandner Sigrid E; Najafian Nader; Salama Alan D; Dong Victor; Yamada Akira; Kishimoto Koji; Harada Hiroshi; Schmitt Isabela; Sayegh Mohamed H
New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs.
Annals of surgery 2002;236(5):667-75.
2002: Makhlouf Leila; Kishimoto Koji; Smith Rex N; Abdi Reza; Koulmanda Maria; Winn Henry J; Auchincloss Hugh; Sayegh Mohamed H
The role of autoimmunity in islet allograft destruction: major histocompatibility complex class II matching is necessary for autoimmune destruction of allogeneic islet transplants after T-cell costimulatory blockade.
Diabetes 2002;51(11):3202-10.
2002: Rolls Hillary K; Kishimoto Koji; Dong Victor M; Illigens Ben M-W; Sho Masayuki; Sayegh Mohamed H; Benichou Gilles; Fedoseyeva Eugenia V
T-cell response to cardiac myosin persists in the absence of an alloimmune response in recipients with chronic cardiac allograft rejection.
Transplantation 2002;74(7):1053-7.
2002: Illigens Ben M; Yamada Akira; Fedoseyeva Eugenia V; Anosova Natalie; Boisgerault Florence; Valujskikh Anna; Heeger Peter S; Sayegh Mohamed H; Boehm Bernhard; Benichou Gilles
The relative contribution of direct and indirect antigen recognition pathways to the alloresponse and graft rejection depends upon the nature of the transplant.
Human immunology 2002;63(10):912-25.
2002: Sho Masayuki; Yamada Akira; Najafian Nader; Salama Alan D; Harada Hiroshi; Sandner Sigrid E; Sanchez-Fueyo Alberto; Zheng Xin Xiao; Strom Terry B; Sayegh Mohamed H
Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3744-51.
2002: Abdi Reza; Smith R Neal; Makhlouf Leila; Najafian Nader; Luster Andrew D; Auchincloss Hugh; Sayegh Mohamed H
The role of CC chemokine receptor 5 (CCR5) in islet allograft rejection.
Diabetes 2002;51(8):2489-95.
2002: Zhai Yuan; Shen Xiu-Da; Gao Feng; Coito Ana J; Wasowska Barbara A; Salama Alan; Schmitt Isabela; Busuttil Ronald W; Sayegh Mohamed H; Kupiec-Weglinski Jerzy W
The CD154-CD40 T cell costimulation pathway is required for host sensitization of CD8(+) T cells by skin grafts via direct antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(3):1270-6.
2002: Fedoseyeva Eugenia V; Kishimoto Koji; Rolls Hillary K; Illigens Ben M-W; Dong Victor M; Valujskikh Anna; Heeger Peter S; Sayegh Mohamed H; Benichou Gilles
Modulation of tissue-specific immune response to cardiac myosin can prolong survival of allogeneic heart transplants.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(3):1168-74.
2002: Kist-van Holthe Joana E; Gasser Martin; Womer Karl; Najafian Nader; Dong Victor; Samsonov Dimitry V; Geehan Chris S; Chandraker Anil; Sayegh Mohamed H; Waaga Ana Maria
Regulatory functions of alloreactive Th2 clones in human renal transplant recipients.
Kidney international 2002;62(2):627-31.
2002: Yuan Xueli; Dong Victor M; Coito Ana J; Waaga Ana-Maria; Salama Alan D; Benjamin Christopher D; Sayegh Mohamed H; Chandraker Anil
A novel CD154 monoclonal antibody in acute and chronic rat vascularized cardiac allograft rejection.
Transplantation 2002;73(11):1736-42.
2002: Salama Alan D; Sayegh Mohamed H
Challenges for the translation of T cell costimulatory blockade therapies to the clinic.
Expert opinion on biological therapy 2002;2(5):453-7.
2002: Kishimoto Koji; Sandner Sigrid; Imitola Jaime; Sho Masayuki; Li Yongsheng; Langmuir Peter B; Rothstein David M; Strom Terry B; Turka Laurence A; Sayegh Mohamed H
Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance.
The Journal of clinical investigation 2002;109(11):1471-9.
2002: Chung Doo Ryeon; Chitnis Tanuja; Panzo Ronald J; Kasper Dennis L; Sayegh Mohamed H; Tzianabos Arthur O
CD4+ T cells regulate surgical and postinfectious adhesion formation.
The Journal of experimental medicine 2002;195(11):1471-8.
2002: Johnston Douglas R; Sayegh Mohamed H; Madsen Joren C
Overcoming cardiac allograft vasculopathy (CAV) by inducing tolerance.
Frontiers in bioscience : a journal and virtual library 2002;7():e116-8.
2002: Dong Victor M; Yuan Xueli; Coito Ana J; Waaga Ana Maria; Sayegh Mohamed H; Chandraker Anil
Mechanisms of targeting CD28 by a signaling monoclonal antibody in acute and chronic allograft rejection.
Transplantation 2002;73(8):1310-7.
2002: Briscoe David M; Sayegh Mohamed H
A rendezvous before rejection: where do T cells meet transplant antigens?
Nature medicine 2002;8(3):220-2.
2002: Yamada Akira; Salama Alan D; Sayegh Mohamed H
The role of novel T cell costimulatory pathways in autoimmunity and transplantation.
Journal of the American Society of Nephrology : JASN 2002;13(2):559-75.
2002: Laskowski Igor A; Pratschke Johann; Wilhelm Markus J; Dong Victor M; Beato Francisca; Taal Maarten; Gasser Martin; Hancock Wayne W; Sayegh Mohamed H; Tilney Nicholas L
Anti-CD28 monoclonal antibody therapy prevents chronic rejection of renal allografts in rats.
Journal of the American Society of Nephrology : JASN 2002;13(2):519-27.
2002: Yamada And Akira; Sayegh Mohamed H
The CD154-CD40 costimulatory pathway in transplantation.
Transplantation 2002;73(1 Suppl):S36-9.
2002: Donato José L; Ko Jon; Kutok Jeffery L; Cheng Tao; Shirakawa Taro; Mao Xiao-Quan; Beach David; Scadden David T; Sayegh Mohamed H; Adra Chaker N
Human HTm4 is a hematopoietic cell cycle regulator.
The Journal of clinical investigation 2002;109(1):51-8.
2002: Najafian Nader; Salama Alan D; Fedoseyeva Eugenia V; Benichou Gilles; Sayegh Mohamed H
Enzyme-linked immunosorbent spot assay analysis of peripheral blood lymphocyte reactivity to donor HLA-DR peptides: potential novel assay for prediction of outcomes for renal transplant recipients.
Journal of the American Society of Nephrology : JASN 2002;13(1):252-9.
2001: Sho M; Salama A D; Yamada A; Najafian N; Sayegh M H
Physiologic regulation of alloimmune responses in vivo: the role of CTLA4 and TH1/TH2 cytokines.
Transplantation proceedings 2001;33(7-8):3826-8.
2001: Rolls H K; Kishimoto K; Illigens B M; Dong V; Sayegh M H; Benichou G; Fedoseyeva E V
Detection of cardiac myosin-specific autoimmunity in a model of chronic heart allograft rejection.
Transplantation proceedings 2001;33(7-8):3821-2.
2001: Yamada A; Salama A D; Najafian N; Auchincloss H; Sayegh M H
TNF:TNF-R T-Cell costimulatory pathways in transplantation.
Transplantation proceedings 2001;33(7-8):3070-1.
2001: Salamam A D; Sayegh M H
Achieving clinical transplant tolerance: what are the hurdles?
Transplantation proceedings 2001;33(7-8):3038-40.
2001: Yamada A; Chandraker A; Laufer T M; Gerth A J; Sayegh M H; Auchincloss H
Recipient MHC class II expression is required to achieve long-term survival of murine cardiac allografts after costimulatory blockade.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5522-6.
2001: Womer K L; Stone J R; Murphy B; Chandraker A; Sayegh M H
Indirect allorecognition of donor class I and II major histocompatibility complex peptides promotes the development of transplant vasculopathy.
Journal of the American Society of Nephrology : JASN 2001;12(11):2500-6.
2001: Salama A D; Remuzzi G; Harmon W E; Sayegh M H
Challenges to achieving clinical transplantation tolerance.
The Journal of clinical investigation 2001;108(7):943-8.
2001: Denton M D; Galvanek E G; Singh A; Sayegh M H
Membranous lupus nephritis in a renal allograft: response to mycophenolate mofetil therapy.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2001;1(3):288-92.
2001: Najafian N; Khoury S J; Sayegh M H
T cell costimulatory blockade as a novel immune intervention in autoimmune diseases.
Clinics in dermatology 2001;19(5):586-91.
2001: Chitnis T; Najafian N; Benou C; Salama A D; Grusby M J; Sayegh M H; Khoury S J
Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis.
The Journal of clinical investigation 2001;108(5):739-47.
2001: Mandelbrot D A; Kishimoto K; Auchincloss H; Sharpe A H; Sayegh M H
Rejection of mouse cardiac allografts by costimulation in trans.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1174-8.
2001: Yamada A; Kishimoto K; Dong V M; Sho M; Salama A D; Anosova N G; Benichou G; Mandelbrot D A; Sharpe A H; Turka L A; Auchincloss H; Sayegh M H
CD28-independent costimulation of T cells in alloimmune responses.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):140-6.
2001: Azuma H; Takahara S; Matsumoto K; Ichimaru N; Wang J D; Moriyama T; Waaga A M; Kitamura M; Otsuki Y; Okuyama A; Katsuoka Y; Chandraker A; Sayegh M H; Nakamura T
Hepatocyte growth factor prevents the development of chronic allograft nephropathy in rats.
Journal of the American Society of Nephrology : JASN 2001;12(6):1280-92.
2001: Womer K L; Lee R S; Madsen J C; Sayegh M H
Tolerance and chronic rejection.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1409):727-38.
2001: Womer K L; Sayegh M H; Auchincloss H
Involvement of the direct and indirect pathways of allorecognition in tolerance induction.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1409):639-47.
2001: Waaga A M; Gasser M; Kist-van Holthe J E; Najafian N; Müller A; Vella J P; Womer K L; Chandraker A; Khoury S J; Sayegh M H
Regulatory functions of self-restricted MHC class II allopeptide-specific Th2 clones in vivo.
The Journal of clinical investigation 2001;107(7):909-16.
2001: Mandelbrot D A; Oosterwegel M A; Shimizu K; Yamada A; Freeman G J; Mitchell R N; Sayegh M H; Sharpe A H
B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4.
The Journal of clinical investigation 2001;107(7):881-7.
2001: Lee R S; Yamada K; Houser S L; Womer K L; Maloney M E; Rose H S; Sayegh M H; Madsen J C
Indirect recognition of allopeptides promotes the development of cardiac allograft vasculopathy.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3276-81.
2001: Chitnis T; Najafian N; Abdallah K A; Dong V; Yagita H; Sayegh M H; Khoury S J
CD28-independent induction of experimental autoimmune encephalomyelitis.
The Journal of clinical investigation 2001;107(5):575-83.
2001: Kim K S; Denton M D; Chandraker A; Knoflach A; Milord R; Waaga A M; Turka L A; Russell M E; Peach R; Sayegh M H
CD28-B7-mediated T cell costimulation in chronic cardiac allograft rejection: differential role of B7-1 in initiation versus progression of graft arteriosclerosis.
The American journal of pathology 2001;158(3):977-86.
2001: Laskowski I A; Pratschke J; Wilhelm M J; Paz D; Ames J B; Dong V M; Beato F; Sayegh M H; Hancock W W; Tilney N L
Prolongation of survival and preservation of allograft structure and function by a signaling CD28 mAB in a rat model of chronic kidney rejection.
Transplantation proceedings 2001;33(1-2):567-8.
2001: Lee R S; Yamada K; Houser S L; Womer K L; Maloney M E; Rose H S; Sayegh M H; Madsen J C
Indirect allorecognition promotes the development of cardiac allograft vasculopathy.
Transplantation proceedings 2001;33(1-2):308-10.
2001: Kupiec-Weglinski J W; Shen X D; Gao F; Zhai Y; Coito A J; Sayegh M H
CD40 ligand-CD40 T cell costimulation pathway is required for host sensitization in the immune cascade leading to accelerated allograft rejection.
Transplantation proceedings 2001;33(1-2):304-5.
2001: Lee R S; Rusche J R; Maloney M E; Sachs D H; Sayegh M H; Madsen J C
CTLA4Ig-induced linked regulation of allogeneic T cell responses.
Transplantation proceedings 2001;33(1-2):88-9.
2001: Frank M H; Denton M D; Alexander S I; Khoury S J; Sayegh M H; Briscoe D M
Specific MDR1 P-glycoprotein blockade inhibits human alloimmune T cell activation in vitro.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2451-9.
2001: Wekerle T; Kurtz J; Sayegh M; Ito H; Wells A; Bensinger S; Shaffer J; Turka L; Sykes M
Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2311-6.
2001: Lee R S; Rusche J R; Maloney M E; Sachs D H; Sayegh M H; Madsen J C
CTLA4Ig-induced linked regulation of allogeneic T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):1572-82.
2001: Suchin E J; Langmuir P B; Palmer E; Sayegh M H; Wells A D; Turka L A
Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):973-81.
2001: Fecteau S; Basadonna G P; Freitas A; Ariyan C; Sayegh M H; Rothstein D M
CTLA-4 up-regulation plays a role in tolerance mediated by CD45.
Nature immunology 2001;2(1):58-63.
2001: Rothstein D M; Livak M F; Kishimoto K; Ariyan C; Qian H Y; Fecteau S; Sho M; Deng S; Zheng X X; Sayegh M H; Basadonna G P
Targeting signal 1 through CD45RB synergizes with CD40 ligand blockade and promotes long term engraftment and tolerance in stringent transplant models.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):322-9.
2000: Tzianabos A O; Chandraker A; Kalka-Moll W; Stingele F; Dong V M; Finberg R W; Peach R; Sayegh M H
Bacterial pathogens induce abscess formation by CD4(+) T-cell activation via the CD28-B7-2 costimulatory pathway.
Infection and immunity 2000;68(12):6650-5.
2000: Tran H T; Acharya M K; McKay D B; Sayegh M H; Carpenter C B; Auchincloss H J R; Kirkman R L; Milford E L
Avoidance of cyclosporine in renal transplantation: effects of daclizumab, mycophenolate mofetil, and steroids.
Journal of the American Society of Nephrology : JASN 2000;11(10):1903-9.
2000: Najafian N; Sayegh M H
CTLA4-Ig: a novel immunosuppressive agent.
Expert opinion on investigational drugs 2000;9(9):2147-57.
2000: Kishimoto K; Dong V M; Issazadeh S; Fedoseyeva E V; Waaga A M; Yamada A; Sho M; Benichou G; Auchincloss H; Grusby M J; Khoury S J; Sayegh M H
The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo.
The Journal of clinical investigation 2000;106(1):63-72.
2000: Stadlbauer T H; Schaub M; Magee C C; Kupiec-Weglinski J W; Sayegh M H
Intrathymic immunomodulation in sensitized rat recipients of cardiac allografts: requirements for allorecognition pathways.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2000;19(6):566-75.
2000: Issazadeh S; Abdallah K; Chitnis T; Chandraker A; Wells A D; Turka L A; Sayegh M H; Khoury S J
Role of passive T-cell death in chronic experimental autoimmune encephalomyelitis.
The Journal of clinical investigation 2000;105(8):1109-16.
2000: Wekerle T; Kurtz J; Ito H; Ronquillo J V; Dong V; Zhao G; Shaffer J; Sayegh M H; Sykes M
Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment.
Nature medicine 2000;6(4):464-9.
2000: Womer K L; Vella J P; Sayegh M H
Chronic allograft dysfunction: mechanisms and new approaches to therapy.
Seminars in nephrology 2000;20(2):126-47.
2000: Lee R S; Yamada K; Womer K L; Pillsbury E P; Allison K S; Marolewski A E; Geng D; Thall A D; Arn J S; Sachs D H; Sayegh M H; Madsen J C
Blockade of CD28-B7, but not CD40-CD154, prevents costimulation of allogeneic porcine and xenogeneic human anti-porcine T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):3434-44.
1999: Guttormsen H K; Sharpe A H; Chandraker A K; Brigtsen A K; Sayegh M H; Kasper D L
Cognate stimulatory B-cell-T-cell interactions are critical for T-cell help recruited by glycoconjugate vaccines.
Infection and immunity 1999;67(12):6375-84.
1999: Wekerle T; Sayegh M H; Ito H; Hill J; Chandraker A; Pearson D A; Swenson K G; Zhao G; Sykes M
Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance.
Transplantation 1999;68(9):1348-55.
1999: Wells A D; Li X C; Li Y; Walsh M C; Zheng X X; Wu Z; Nuñez G; Tang A; Sayegh M; Hancock W W; Strom T B; Turka L A
Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance.
Nature medicine 1999;5(11):1303-7.
1999: Magee C C; Azuma H; Knoflach A; Denton M D; Chandraker A; Iyer S; Buelow R; Sayegh M
In vitro and in vivo immunomodulatory effects of RDP1258, a novel synthetic peptide.
Journal of the American Society of Nephrology : JASN 1999;10(9):1997-2005.
1999: Dong V M; Womer K L; Sayegh M H
Transplantation tolerance: the concept and its applicability.
Pediatric transplantation 1999;3(3):181-92.
1999: Denton M D; Geehan C S; Alexander S I; Sayegh M H; Briscoe D M
Endothelial cells modify the costimulatory capacity of transmigrating leukocytes and promote CD28-mediated CD4(+) T cell alloactivation.
The Journal of experimental medicine 1999;190(4):555-66.
1999: Saborio D V; Chowdhury N C; Jin M X; Chandraker A; Sayegh M H; Oluwole S F
Regulatory T cells maintain peripheral tolerance to islet allografts induced by intrathymic injection of MHC class I allopeptides.
Cell transplantation 1999;8(4):375-81.
1999: Magee C C; Halligan R D; Milford E L; Sayegh M H
Nocardial infection in a renal transplant recipient on tacrolimus and mycophenolate mofetil.
Clinical nephrology 1999;52(1):44-6.
1999: Onodera K; Chandraker A; Volk H D; Ritter T; Lehmann M; Kato H; Sayegh M H; Kupiec-Weglinski J W
Distinct tolerance pathways in sensitized allograft recipients after selective blockade of activation signal 1 or signal 2.
Transplantation 1999;68(2):288-93.
1999: Vella J P; Magee C; Vos L; Womer K; Rennke H; Carpenter C B; Hancock W; Sayegh M H
Cellular and humoral mechanisms of vascularized allograft rejection induced by indirect recognition of donor MHC allopeptides.
Transplantation 1999;67(12):1523-32.
1999: Schaub M; Issazadeh S; Stadlbauer T H; Peach R; Sayegh M H; Khoury S J
Costimulatory signal blockade in murine relapsing experimental autoimmune encephalomyelitis.
Journal of neuroimmunology 1999;96(2):158-66.
1999: Knoflach A; Azuma H; Magee C; Denton M; Murphy B; Iyengar A; Buelow R; Sayegh M H
Immunomodulatory functions of low-molecular weight hyaluronate in an acute rat renal allograft rejection model.
Journal of the American Society of Nephrology : JASN 1999;10(5):1059-66.
1999: Sayegh M H
Finally, CTLA4Ig graduates to the clinic.
The Journal of clinical investigation 1999;103(9):1223-5.
1999: Zheng X X; Markees T G; Hancock W W; Li Y; Greiner D L; Li X C; Mordes J P; Sayegh M H; Rossini A A; Strom T B
CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4983-90.
1999: Knoflach A; Magee C; Denton M D; Kim K S; Buelow R; Hancock W W; Sayegh M H
Immunomodulatory functions of hyaluronate in the LEW-to-F344 model of chronic cardiac allograft rejection.
Transplantation 1999;67(6):909-14.
1999: Denton M D; Magee C C; Sayegh M H
Immunosuppressive strategies in transplantation.
Lancet 1999;353(9158):1083-91.
1999: Murphy B; Magee C C; Alexander S I; Waaga A M; Snoeck H W; Vella J P; Carpenter C B; Sayegh M H
Inhibition of allorecognition by a human class II MHC-derived peptide through the induction of apoptosis.
The Journal of clinical investigation 1999;103(6):859-67.
1999: Onodera K; Chandraker A; Kato H; Volk H D; Sayegh M H; Kupiec-Weglinski J W
Distinct tolerance pathways in sensitized rat recipients after blockade of activation signal 1 and signal 2.
Transplantation proceedings 1999;31(1-2):876-7.
1999: Wekerle T; Sayegh M H; Chandraker A; Swenson K G; Zhao Y; Sykes M
Role of peripheral clonal deletion in tolerance induction with bone marrow transplantation and costimulatory blockade.
Transplantation proceedings 1999;31(1-2):680.
1999: Zheng X X; Li Y; Li X C; Roy-Chaudhury P; Nickerson P; Tian Y; Sayegh M H; Strom T B
Blockade of CD40L/CD40 costimulatory pathway in a DST presensitization model of islet allograft leads to a state of Allo-Ag specific tolerance and permits subsequent engraftment of donor strain islet or heart allografts.
Transplantation proceedings 1999;31(1-2):627-8.
1999: Judge T A; Wu Z; Zheng X G; Sharpe A H; Sayegh M H; Turka L A
The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):1947-51.
1999: Issazadeh S; Zhang M; Sayegh M H; Khoury S J
Acquired thymic tolerance: role of CTLA4 in the initiation and maintenance of tolerance in a clinically relevant autoimmune disease model.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):761-5.
1999: Khoury S; Sayegh M H; Turka L A
Blocking costimulatory signals to induce transplantation tolerance and prevent autoimmune disease.
International reviews of immunology 1999;18(3):185-99.
1998: Vella J P; Sayegh M H; Turka L A
Developments in the clinical science of transplantation during the 20th century.
Pediatric transplantation 1998;2(4):257-62.
1998: Mark D A; Donovan C E; De Sanctis G T; Krinzman S J; Kobzik L; Linsley P S; Sayegh M H; Lederer J; Perkins D L; Finn P W
Both CD80 and CD86 co-stimulatory molecules regulate allergic pulmonary inflammation.
International immunology 1998;10(11):1647-55.
1998: Chowdhury N C; Saborio D V; Garrovillo M; Chandraker A; Magee C C; Waaga A M; Sayegh M H; Jin M X; Oluwole S F
Comparative studies of specific acquired systemic tolerance induced by intrathymic inoculation of a single synthetic Wistar-Furth (RT1U) allo-MHC class I (RT1.AU) peptide or WAG (RT1U)-derived class I peptide.
Transplantation 1998;66(8):1059-66.
1998: Magee C C; Sayegh M H
Peptide mediated immunosuppression: new developments.
Transplantation proceedings 1998;30(5):2131-5.
1998: Issazadeh S; Navikas V; Schaub M; Sayegh M; Khoury S
Kinetics of expression of costimulatory molecules and their ligands in murine relapsing experimental autoimmune encephalomyelitis in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(3):1104-12.
1998: Takada M; Nadeau K C; Hancock W W; Mackenzie H S; Shaw G D; Waaga A M; Chandraker A; Sayegh M H; Tilney N L
Effects of explosive brain death on cytokine activation of peripheral organs in the rat.
Transplantation 1998;65(12):1533-42.
1998: Kato H; Onodera K; Chandraker A; Volk H D; Sayegh M H; Kupiec-Weglinski J W
CD4-targeted therapy and CD28-B7 costimulatory blockage may independently induce tolerance in sensitized allograft recipients.
Transplantation proceedings 1998;30(4):1063-4.
1998: Sayegh M H; Turka L A
The role of T-cell costimulatory activation pathways in transplant rejection.
The New England journal of medicine 1998;338(25):1813-21.
1998: Chandraker A; Azuma H; Nadeau K; Carpenter C B; Tilney N L; Hancock W W; Sayegh M H
Late blockade of T cell costimulation interrupts progression of experimental chronic allograft rejection.
The Journal of clinical investigation 1998;101(11):2309-18.
1998: Schaub M; Stadlbauer T H; Chandraker A; Vella J P; Turka L A; Sayegh M H
Comparative strategies to induce long-term graft acceptance in fully allogeneic renal versus cardiac allograft models by CD28-B7 T cell costimulatory blockade: role of thymus and spleen.
Journal of the American Society of Nephrology : JASN 1998;9(5):891-8.
1998: Waaga A M; Chandraker A; Spadafora-Ferreira M; Iyengar A R; Khoury S J; Carpenter C B; Sayegh M H
Mechanisms of indirect allorecognition: characterization of MHC class II allopeptide-specific T helper cell clones from animals undergoing acute allograft rejection.
Transplantation 1998;65(7):876-83.
1998: Chertow G M; Lazarus J M; Paganini E P; Allgren R L; Lafayette R A; Sayegh M H
Predictors of mortality and the provision of dialysis in patients with acute tubular necrosis. The Auriculin Anaritide Acute Renal Failure Study Group.
Journal of the American Society of Nephrology : JASN 1998;9(4):692-8.
1998: Chen W; Sayegh M H; Khoury S J
Mechanisms of acquired thymic tolerance in vivo: intrathymic injection of antigen induces apoptosis of thymocytes and peripheral T cell anergy.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(3):1504-8.
1998: Onodera K; Chandraker A; Korom S; Stadlbauer T H; Kato K; Kasai S; Sayegh M H; Kupiec-Weglinski J W
Agonistic and antagonistic interactions between CTLA4Ig and donor alloantigens in sensitized rat recipients of cardiac allografts.
Transplantation proceedings 1998;30(1):16-8.
1998: Onodera K; Chandraker A; Volk H D; Lehmann M; Korom S; Stadlbauer T H; Kato K; Kasai S; Sayegh M H; Kupiec-Weglinski J W
Role of regulatory T cells in the "infectious" tolerance pathway in transplant recipients.
Transplantation proceedings 1998;30(1):13-5.
1998: Vella J P; Sayegh M H
Interactions between cyclosporine and newer antidepressant medications.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1998;31(2):320-3.
1997: Vella J P; Vos L; Carpenter C B; Sayegh M H
Role of indirect allorecognition in experimental late acute rejection.
Transplantation 1997;64(12):1823-8.
1997: Stadlbauer T H; Schaub M; Korom S; Onodera K; Sayegh M H; Kupiec-Weglinski J W
CD28-B7 T-cell co-stimulatory blockade potentiates the effects of intrathymic immunomodulation in sensitized graft recipients.
Transplantation 1997;64(12):1816-22.
1997: Sayegh M H; Zheng X G; Magee C; Hancock W W; Turka L A
Donor antigen is necessary for the prevention of chronic rejection in CTLA4Ig-treated murine cardiac allograft recipients.
Transplantation 1997;64(12):1646-50.
1997: Glysing-Jensen T; Räisänen-Sokolowski A; Sayegh M H; Russell M E
Chronic blockade of CD28-B7-mediated T-cell costimulation by CTLA4Ig reduces intimal thickening in MHC class I and II incompatible mouse heart allografts.
Transplantation 1997;64(12):1641-5.
1997: Chandraker A; Takada M; Nadeau K C; Peach R; Tilney N L; Sayegh M H
CD28-b7 blockade in organ dysfunction secondary to cold ischemia/reperfusion injury.
Kidney international 1997;52(6):1678-84.
1997: Gallon L; Chandraker A; Issazadeh S; Peach R; Linsley P S; Turka L A; Sayegh M H; Khoury S J
Differential effects of B7-1 blockade in the rat experimental autoimmune encephalomyelitis model.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(9):4212-6.
1997: Schaub M; Stadlbauer T H; Sayegh M H
CTLA4Ig: effects on cellular and humoral immunity and macrophage activation.
Experimental nephrology 1997;5(5):370-4.
1997: Vella J P; Spadafora-Ferreira M; Murphy B; Alexander S I; Harmon W; Carpenter C B; Sayegh M H
Indirect allorecognition of major histocompatibility complex allopeptides in human renal transplant recipients with chronic graft dysfunction.
Transplantation 1997;64(6):795-800.
1997: Takada M; Chandraker A; Nadeau K C; Sayegh M H; Tilney N L
The role of the B7 costimulatory pathway in experimental cold ischemia/reperfusion injury.
The Journal of clinical investigation 1997;100(5):1199-203.
1997: Chen W; Issazadeh S; Sayegh M H; Khoury S J
In vivo mechanisms of acquired thymic tolerance.
Cellular immunology 1997;179(2):165-73.
1997: Onodera K; Chandraker A; Schaub M; Stadlbauer T H; Korom S; Peach R; Linsley P S; Sayegh M H; Kupiec-Weglinski J W
CD28-B7 T cell costimulatory blockade by CTLA4Ig in sensitized rat recipients: induction of transplantation tolerance in association with depressed cell-mediated and humoral immune responses.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):1711-7.
1997: Zheng X X; Sayegh M H; Zheng X G; Li Y; Linsley P S; Peach R; Borriello F; Strom T B; Sharpe A H; Turka L A
The role of donor and recipient B7-1 (CD80) in allograft rejection.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1169-73.
1997: Murphy B; Kim K S; Buelow R; Sayegh M H; Hancock W W
Synthetic MHC class I peptide prolongs cardiac survival and attenuates transplant arteriosclerosis in the Lewis-->Fischer 344 model of chronic allograft rejection.
Transplantation 1997;64(1):14-9.
1997: Korom S; De Meester I; Stadlbauer T H; Chandraker A; Schaub M; Sayegh M H; Belyaev A; Haemers A; Scharpé S; Kupiec-Weglinski J W
Inhibition of CD26/dipeptidyl peptidase IV activity in vivo prolongs cardiac allograft survival in rat recipients.
Transplantation 1997;63(10):1495-500.
1997: Onodera K; Lehmann M; Volk H D; Sayegh M H; Kupiec-Weglinski J W
CD4-targeted therapy induces "infectious" tolerance to cardiac allografts in sensitized rat recipients.
Transplantation proceedings 1997;29(3):1907-8.
1997: Chandraker A; Russell M E; Glysing-Jensen T; Willett T A; Sayegh M H
T-cell costimulatory blockade in experimental chronic cardiac allograft rejection: effects of cyclosporine and donor antigen.
Transplantation 1997;63(8):1053-8.
1997: Sayegh M H; Carpenter C B
Tolerance and chronic rejection.
Kidney international. Supplement 1997;58():S11-4.
1997: Akalin E; Chandraker A; Sayegh M; Turka L A
Role of the CD28:B7 costimulatory interaction in alloimmune responses.
Kidney international. Supplement 1997;58():S8-10.
1997: Allgren R L; Marbury T C; Rahman S N; Weisberg L S; Fenves A Z; Lafayette R A; Sweet R M; Genter F C; Kurnik B R; Conger J D; Sayegh M H
Anaritide in acute tubular necrosis. Auriculin Anaritide Acute Renal Failure Study Group.
The New England journal of medicine 1997;336(12):828-34.
1997: Onodera K; Hancock W W; Graser E; Volk H D; Lehmann M; Chandraker A; Sayegh M H; Kupiec-Weglinski J W
Th2-type cytokines in the "infectious" tolerance pathway.
Transplantation proceedings 1997;29(1-2):1290-1.
1997: Chowdhury N C; Murphy B; Sayegh M H; Hardy M A; Oluwole S F
Induction of transplant tolerance by intrathymic inoculation of synthetic MHC class I allopeptides.
Transplantation proceedings 1997;29(1-2):1136.
1997: Nadeau K; Azuma H; Chandraker A; Sayegh M H; Tilney N L
Inhibition of CD28-B7 T-cell costimulatory activation pathway affects intragraft cytokine and growth factor expression in chronic renal allograft rejection.
Transplantation proceedings 1997;29(1-2):1038.
1997: Stadlbauer T H; Onodera K; Schaub M; Korom S; Binder J; Sayegh M H; Kupiec-Weglinski J W
Intrathymic immunomodulation of sensitized rat recipients of cardiac allografts: requirements for allorecognition pathways.
Transplantation proceedings 1997;29(1-2):1016.
1997: Waaga A M; Murphy B; Chen W; Khoury S J; Sayegh M H
Class II MHC allopeptide-specific T-cell clones transfer delayed type hypersensitivity responses in vivo.
Transplantation proceedings 1997;29(1-2):1008-9.
1997: Onodera K; Hancock W W; Graser E; Lehmann M; Sayegh M H; Strom T B; Volk H D; Kupiec-Weglinski J W
Type 2 helper T cell-type cytokines and the development of "infectious" tolerance in rat cardiac allograft recipients.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1572-81.
1997: Knoflach A; Chandraker A; Sayegh M H
Chronic rejection from bedside to bench: role of T cells.
Annals of transplantation : quarterly of the Polish Transplantation Society 1997;2(2):53-60.
1996: Akalin E; Chandraker A; Russell M E; Turka L A; Hancock W W; Sayegh M H
CD28-B7 T cell costimulatory blockade by CTLA4Ig in the rat renal allograft model: inhibition of cell-mediated and humoral immune responses in vivo.
Transplantation 1996;62(12):1942-5.
1996: Chowdhury N C; Murphy B; Sayegh M H; Jin M X; Roy D K; Hardy M A; Oluwole S F
Acquired systemic tolerance to rat cardiac allografts induced by intrathymic inoculation of synthetic polymorphic MHC class I allopeptides.
Transplantation 1996;62(12):1878-82.
1996: Hancock W W; Sayegh M H; Zheng X G; Peach R; Linsley P S; Turka L A
Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13967-72.
1996: Azuma H; Chandraker A; Nadeau K; Hancock W W; Carpenter C B; Tilney N L; Sayegh M H
Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12439-44.
1996: Khoury S J; Gallon L; Verburg R R; Chandraker A; Peach R; Linsley P S; Turka L A; Hancock W W; Sayegh M H
Ex vivo treatment of antigen-presenting cells with CTLA4Ig and encephalitogenic peptide prevents experimental autoimmune encephalomyelitis in the Lewis rat.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(8):3700-5.
1996: Chen W; Murphy B; Waaga A M; Willett T A; Russell M E; Khoury S J; Sayegh M H
Mechanisms of indirect allorecognition in graft rejection: class II MHC allopeptide-specific T cell clones transfer delayed-type hypersensitivity responses in vivo.
Transplantation 1996;62(6):705-10.
1996: Onodera K; Lehmann M; Akalin E; Volk H D; Sayegh M H; Kupiec-Weglinski J W
Induction of "infectious" tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(5):1944-50.
1996: Chertow G M; Sayegh M H; Allgren R L; Lazarus J M
Is the administration of dopamine associated with adverse or favorable outcomes in acute renal failure? Auriculin Anaritide Acute Renal Failure Study Group.
The American journal of medicine 1996;101(1):49-53.
1996: Murphy B; Sayegh M H
Immunomodulatory function of major histocompatibility complex-derived peptides.
Current opinion in nephrology and hypertension 1996;5(3):262-8.
1996: Murphy B; Auchincloss H; Carpenter C B; Sayegh M H
T cell recognition of xeno-MHC peptides during concordant xenograft rejection.
Transplantation 1996;61(8):1133-7.
1996: Judge T A; Tang A; Spain L M; Deans-Gratiot J; Sayegh M H; Turka L A
The in vivo mechanism of action of CTLA4Ig.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(6):2294-9.
1996: Binder J; Lehmann M; Graser E; Hancock W W; Watschinger B; Onodera K; Sayegh M H; Volk H D; Kupiec-Weglinski J W
The effects of nondepleting CD4 targeted therapy in presensitized rat recipients of cardiac allografts.
Transplantation 1996;61(5):804-11.
1996: Sayegh M H; Khoury S J; Hancock W W; Weiner H L; Carpenter C B
Mechanisms of oral tolerance by MHC peptides.
Annals of the New York Academy of Sciences 1996;778():338-45.
1996: Russell M E; Hancock W W; Akalin E; Wallace A F; Glysing-Jensen T; Willett T A; Sayegh M H
Chronic cardiac rejection in the LEW to F344 rat model. Blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis.
The Journal of clinical investigation 1996;97(3):833-8.
1996: Sayegh M H; Carpenter C B
Role of indirect allorecognition in allograft rejection.
International reviews of immunology 1996;13(3):221-9.
1995: Binder J; Graser E; Hancock W W; Wasowska B; Sayegh M H; Volk H D; Kupiec-Weglinski J W
Downregulation of intragraft IFN-gamma expression correlates with increased IgG1 alloantibody response following intrathymic immunomodulation of sensitized rat recipients.
Transplantation 1995;60(12):1516-24.
1995: Khoury S J; Akalin E; Chandraker A; Turka L A; Linsley P S; Sayegh M H; Hancock W W
CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4521-4.
1995: Khoury S J; Gallon L; Chen W; Betres K; Russell M E; Hancock W W; Carpenter C B; Sayegh M H; Weiner H L
Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo.
The Journal of experimental medicine 1995;182(2):357-66.
1995: Shin Y T; Adams D H; Wyner L R; Akalin E; Sayegh M H; Karnovsky M J
Intrathymic injection of donor splenocytes plus systemic antilymphocyte serum or antilymphocyte serum alone prolongs cardiac allograft survival and inhibits graft arteriosclerosis in the Lewis-to-F344 chronic rejection model.
Transplantation proceedings 1995;27(3):2112-4.
1995: Shin Y T; Adams D H; Wyner L R; Akalin E; Sayegh M H; Karnovsky M J
Intrathymic tolerance in the Lewis-to-F344 chronic cardiac allograft rejection model.
Transplantation 1995;59(12):1647-53.
1995: Watschinger B; Sayegh M H; Hancock W W; Russell M E
Up-regulation of endothelin-1 mRNA and peptide expression in rat cardiac allografts with rejection and arteriosclerosis.
The American journal of pathology 1995;146(5):1065-72.
1995: Sayegh M H; Akalin E; Hancock W W; Russell M E; Carpenter C B; Linsley P S; Turka L A
CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.
The Journal of experimental medicine 1995;181(5):1869-74.
1995: Murphy B; Akalin E; Watschinger B; Carpenter C B; Sayegh M H
Inhibition of the alloimmune response with synthetic nonpolymorphic class II MHC peptides.
Transplantation proceedings 1995;27(1):409-10.
1995: Binder J; Hancock W W; Watschinger B; Wasowska B; Sayegh M H; Kupiec-Weglinski J W
Abrogation of accelerated allograft rejection by intrathymic injection of donor spleen cells is associated with upregulation of donor-reactive IgM, IgG1, and IgG2A, but depression of IgG2B in the circulation and at the graft site.
Transplantation proceedings 1995;27(1):138-41.
1995: Binder J; Hancock W W; Wasowska B; Gallon L; Watschinger B; Sayegh M H; Brock J; Lehmann M; Volk H D; Kupiec-Weglinski J W
Donor-specific transplantation unresponsiveness in sensitized rats following treatment with a nondepleting anti-CD4 MAb is associated with selective intragraft sparing of Th2-like cells.
Transplantation proceedings 1995;27(1):114-6.
1995: Gallon L; Watschinger B; Murphy B; Akalin E; Sayegh M H; Carpenter C B
The indirect pathway of allorecognition. The occurrence of self-restricted T cell recognition of allo-MHC peptides early in acute renal allograft rejection and its inhibition by conventional immunosuppression.
Transplantation 1995;59(4):612-6.
1995: Binder J; Hancock W W; Watschinger B; Wasowska B; Sayegh M H; Kupiec-Weglinski J W
The alloantibody network following intrathymic immunomodulation of sensitized rat recipients of cardiac allografts.
Transplantation 1995;59(4):590-7.
1995: Russell M E; Wallace A F; Hancock W W; Sayegh M H; Adams D H; Sibinga N E; Wyner L R; Karnovsky M J
Upregulation of cytokines associated with macrophage activation in the Lewis-to-F344 rat transplantation model of chronic cardiac rejection.
Transplantation 1995;59(4):572-8.
1995: Akalin E; Hancock W W; Perico N; Remuzzi G; Imberti O; Carpenter C B; Sayegh M H
Blocking cell microtubule assembly inhibits the alloimmune response in vitro and prolongs renal allograft survival by inhibition of Th1 and sparing of Th2 cell function in vivo.
Journal of the American Society of Nephrology : JASN 1995;5(7):1418-25.
1994: Brandeis J M; Sayegh M H; Gallon L; Blumberg R S; Carpenter C B
Rat intestinal epithelial cells present major histocompatibility complex allopeptides to primed T cells.
Gastroenterology 1994;107(5):1537-42.
1994: Sayegh M H; Perico N; Gallon L; Imberti O; Hancock W W; Remuzzi G; Carpenter C B
Mechanisms of acquired thymic unresponsiveness to renal allografts. Thymic recognition of immunodominant allo-MHC peptides induces peripheral T cell anergy.
Transplantation 1994;58(2):125-32.
1994: Binder J; Sayegh M H; Watschinger B; Hancock W W; Kupiec-Weglinski J W
Intrathymic injection of donor-specific X-irradiation-sensitive spleen cells abrogates accelerated rejection of cardiac allografts in sensitized rats.
Transplantation 1994;58(1):80-6.
1994: Karnovsky M J; Russell M E; Hancock W; Sayegh M H; Adams D H
Chronic rejection in experimental cardiac transplantation in a rat model.
Clinical transplantation 1994;8(3 Pt 2):308-12.
1994: Xia W; Sayegh M H; Kirkman R L
Intrathymic injection of allogeneic cells induces indefinite survival of cardiac but not small bowel grafts.
Transplantation proceedings 1994;26(3):1581.
1994: Xia W; Brandeis J M; Sayegh M; Kirkman R L
Mesenteric and intraepithelial lymphocytes are insufficient to cause rejection but able to mediate lethal graft-versus-host disease in small bowel transplants.
Transplantation proceedings 1994;26(3):1508-9.
1994: Sayegh M H; Watschinger B; Carpenter C B
Mechanisms of T cell recognition of alloantigen. The role of peptides.
Transplantation 1994;57(9):1295-302.
1994: Frem G J; Rennke H G; Sayegh M H
Late renal allograft failure secondary to thrombotic microangiopathy-human immunodeficiency virus nephropathy.
Journal of the American Society of Nephrology : JASN 1994;4(9):1643-8.
1994: Watschinger B; Gallon L; Carpenter C B; Sayegh M H
Mechanisms of allo-recognition. Recognition by in vivo-primed T cells of specific major histocompatibility complex polymorphisms presented as peptides by responder antigen-presenting cells.
Transplantation 1994;57(4):572-6.
1993: Kupiec-Weglinski J W; Wasowska B; Papp I; Schmidbauer G; Sayegh M H; Baldwin W M; Wieder K J; Hancock W W
CD4 mAb therapy modulates alloantibody production and intracardiac graft deposition in association with selective inhibition of Th1 lymphokines.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(9):5053-61.
1993: Sayegh M H; Perico N; Imberti O; Hancock W W; Carpenter C B; Remuzzi G
Thymic recognition of class II major histocompatibility complex allopeptides induces donor-specific unresponsiveness to renal allografts.
Transplantation 1993;56(2):461-5.
1993: Khoury S J; Sayegh M H; Hancock W W; Gallon L; Carpenter C B; Weiner H L
Acquired tolerance to experimental autoimmune encephalomyelitis by intrathymic injection of myelin basic protein or its major encephalitogenic peptide.
The Journal of experimental medicine 1993;178(2):559-66.
1993: Sayegh M H; Khoury S J; Hancock W W; Weiner H L; Carpenter C B
Induction of immunity and oral tolerance to alloantigen by polymorphic class II major histocompatibility complex allopeptides in the rat.
Transplantation proceedings 1993;25(1 Pt 1):357-8.
1992: Sayegh M H; Khoury S J; Hancock W W; Weiner H L; Carpenter C B
Induction of immunity and oral tolerance with polymorphic class II major histocompatibility complex allopeptides in the rat.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7762-6.
1992: Sablinski T; Sayegh M H; Kut J P; Milford E L; Tilney N L; Kupiec-Weglinski J W
Evidence that therapeutic strategies targeted at CD4+ cells modulate accelerated rejection of cardiac allografts in sensitized rats by different mechanisms.
Transplantation 1992;54(2):292-6.
1992: Hancock W W; Sayegh M H; Sablinski T; Kut J P; Kupiec-Weglinski J W; Milford E L
Blocking of mononuclear cell accumulation, cytokine production, and endothelial activation within rat cardiac allografts by CD4 monoclonal antibody therapy.
Transplantation 1992;53(6):1276-80.
1992: Sablinski T; Sayegh M H; Kut J P; Tilney N L; Milford E L; Kupiec-Weglinski J W
The importance of targeting the CD4+ T cell subset at the time of antigenic challenge for induction of prolonged vascularized allograft survival.
Transplantation 1992;53(1):219-21.
1991: Cudkowicz M E; Sayegh M H; Rennke H G
Membranous nephropathy in a patient with renal cell carcinoma.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1991;17(3):349-51.
1991: Sablinski T; Sayegh M H; Kut J P; Hancock W W; Milford E L; Tilney N L; Kupiec-Weglinski J W
Therapeutic strategies targeted at CD4+ cells obviate accelerated rejection of cardiac allografts in sensitized rats.
Transplantation proceedings 1991;23(1 Pt 1):268-9.
1991: Sayegh M H; Sablinski T; Tanaka K; Kut J P; Kwok C A; Tilney N L; Kupiec-Weglinski J W; Milford E L
Effects of BWH-4 anti-CD4 monoclonal antibody on rat vascularized cardiac allografts before and after engraftment.
Transplantation 1991;51(2):296-9.
1991: Sablinski T; Sayegh M H; Hancock W W; Kut J P; Kwok C A; Milford E L; Tilney N L; Kupiec-Weglinski J W
Differential role of CD4+ cells in the sensitization and effector phases of accelerated graft rejection.
Transplantation 1991;51(1):226-31.
1990: Silverman D H; Sayegh M H; Alvarez C E; Johnson T S; Milford E L; Karnovsky M L
HLA class II-restricted binding of muramyl peptides to B lymphocytes of normal and narcoleptic subjects.
Human immunology 1990;27(3):145-54.
1989: Sayegh M H; Turka L A; Milford E L; Carpenter C B
Mixed lymphocyte response-generated suppressor cell specificity in humans is major histocompatibility complex-restricted.
Human immunology 1989;26(4):281-7.
1989: Frankel A H; Sayegh M H; Rothstein D M; Milford E L; Carpenter C B
Requirements for the induction of allospecific CD8+ suppressor T cells in the rat primary mixed lymphocyte response. CD4+, CD45R+ T cells, or supernatant factor.
Transplantation 1989;48(4):639-46.
1989: Sayegh M H; Kut J P; Milford E L
Anti-CD4 monoclonal antibody effects cellular hyporesponsiveness and prolongs renal allograft survival in the rat.
Human immunology 1989;26(2):131-6.

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