FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Thomas Sayers

Research Profile

Living Beings

Anatomy

Chemicals & Drugs

Physiology

Cytotoxicity, Immunologic

Disorders

Co-author Network

Publications

TOP 3
Emily L Whitson; Christian Griesinger; Curtis J Henrich; James B McMahon; Thomas J Sayers; Han Sun; Cheryl L Thomas; Tawnya C McKee
Synergistic TRAIL sensitizers from Barleria alluaudii and Diospyros maritima.
Emily L Whitson; Cheryl L Thomas; Curtis J Henrich; Thomas J Sayers; James B McMahon; Tawnya C McKee
Clerodane diterpenes from Casearia arguta that act as synergistic TRAIL sensitizers.
Alan D Brooks; Kristen M Jacobsen; Wenqing Li; Anil Shanker; Thomas J Sayers
Bortezomib sensitizes human renal cell carcinomas to TRAIL apoptosis through increased activation of caspase-8 in the death-inducing signaling complex.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Thomas Sayers (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Emily L Whitson; Christian Griesinger; Curtis J Henrich; James B McMahon; Thomas J Sayers; Han Sun; Cheryl L Thomas; Tawnya C McKee
Synergistic TRAIL sensitizers from Barleria alluaudii and Diospyros maritima.
Journal of natural products 2012;75(3):394-9.
2010: Emily L Whitson; Cheryl L Thomas; Curtis J Henrich; Thomas J Sayers; James B McMahon; Tawnya C McKee
Clerodane diterpenes from Casearia arguta that act as synergistic TRAIL sensitizers.
Journal of natural products 2010;73(12):2013-8.
2010: Alan D Brooks; Kristen M Jacobsen; Wenqing Li; Anil Shanker; Thomas J Sayers
Bortezomib sensitizes human renal cell carcinomas to TRAIL apoptosis through increased activation of caspase-8 in the death-inducing signaling complex.
Molecular cancer research : MCR 2010;8(5):729-38.
2010: Rachel L de Kluyver; Thomas J Sayers
Breast cancer bone metastases: combination therapy targeting cancer cells and the tumor microenvironment.
Cancer biology & therapy 2010;9(7):551-3.
2009: Anil Shanker; Alan D Brooks; Kristen M Jacobsen; John W Wine; Robert Wiltrout; Hideo Yagita; Thomas J Sayers
Antigen presented by tumors in vivo determines the nature of CD8+ T-cell cytotoxicity.
Cancer research 2009;69(16):6615-23.
2009: Nancy Booth; Thomas J Sayers; Alan D Brooks; Cheryl L Thomas; Kristen Jacobsen; Ekaterina I Goncharova; James B McMahon; Curtis J Henrich
A cell-based high-throughput screen to identify synergistic TRAIL sensitizers.
Cancer immunology, immunotherapy : CII 2009;58(8):1229-44.
2009: Rosalba Salcedo; Julie A Hixon; Jimmy K Stauffer; Rashmi Jalah; Alan D Brooks; Tahira Khan; Ren-Ming Dai; Loretta Scheetz; Erin Lincoln; Timothy C Back; Douglas Powell; Arthur A Hurwitz; Thomas J Sayers; Robert Kastelein; George Pavlakis; Barbara K Felber; Giorgio Trinchieri; JON WIGGINTON
Immunologic and therapeutic synergy of IL-27 and IL-2: enhancement of T cell sensitization, tumor-specific CTL reactivity and complete regression of disseminated neuroblastoma metastases in the liver and bone marrow.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4328-38.
2008: Kai Sun; Minghui Li; Thomas J Sayers; Lisbeth A Welniak; William Murphy
Differential effects of donor T-cell cytokines on outcome with continuous bortezomib administration after allogeneic bone marrow transplantation.
Blood 2008;112(4):1522-9.
2008: William H D Hallett; Erik Ames; Milad Motarjemi; Isabel Barao; Anil Shanker; David L Tamang; Thomas J Sayers; Dorothy Hudig; William Murphy
Sensitization of tumor cells to NK cell-mediated killing by proteasome inhibition.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(1):163-70.
2007: Anil Shanker; Thomas J Sayers
Sensitizing tumor cells to immune-mediated cytotoxicity.
Advances in experimental medicine and biology 2007;601():163-71.
2006: Karen Abdool; Erika Cretney; Alan D Brooks; Janice M Kelly; Jeremy Swann; Anil Shanker; Earl W Bere; Wayne M Yokoyama; John R Ortaldo; Mark J Smyth; Thomas J Sayers
NK cells use NKG2D to recognize a mouse renal cancer (Renca), yet require intercellular adhesion molecule-1 expression on the tumor cells for optimal perforin-dependent effector function.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(4):2575-83.
2006: Tahira Khan; Jimmy K Stauffer; Rebecca Williams; Julie A Hixon; Rosalba Salcedo; Erin Lincoln; Timothy C Back; Douglas Powell; Stephen Lockett; Alma C Arnold; Thomas J Sayers; JON WIGGINTON
Proteasome inhibition to maximize the apoptotic potential of cytokine therapy for murine neuroblastoma tumors.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):6302-12.
2006: Erika Cretney; Anil Shanker; Hideo Yagita; Mark J Smyth; Thomas J Sayers
TNF-related apoptosis-inducing ligand as a therapeutic agent in autoimmunity and cancer.
Immunology and cell biology 2006;84(1):87-98.
2005: Alan D Brooks; Teresa Ramirez; Uhi Toh; Jennifer Onksen; Peter J Elliott; William Murphy; Thomas J Sayers
The proteasome inhibitor bortezomib (Velcade) sensitizes some human tumor cells to Apo2L/TRAIL-mediated apoptosis.
Annals of the New York Academy of Sciences 2005;1059():160-7.
2005: Kai Sun; Danice E C Wilkins; Miriam R Anver; Thomas J Sayers; Angela Panoskaltsis-Mortari; Bruce R Blazar; Lisbeth A Welniak; William Murphy
Differential effects of proteasome inhibition by bortezomib on murine acute graft-versus-host disease (GVHD): delayed administration of bortezomib results in increased GVHD-dependent gastrointestinal toxicity.
Blood 2005;106(9):3293-9.
2005: Jong-Keuk Lee; Naoko Seki; Thomas J Sayers; Jeffrey Subleski; E M Gruys; William Murphy; Robert Wiltrout
Constitutive expression of functional CD40 on mouse renal cancer cells: induction of Fas and Fas-mediated killing by CD40L.
Cellular immunology 2005;235(2):145-52.
2005: Alan D Brooks; Thomas J Sayers
Reduction of the antiapoptotic protein cFLIP enhances the susceptibility of human renal cancer cells to TRAIL apoptosis.
Cancer immunology, immunotherapy : CII 2005;54(5):499-505.
2004: Mark J Smyth; Jeremy Swann; Janice M Kelly; Erika Cretney; Wayne M Yokoyama; Andreas Diefenbach; Thomas J Sayers; Yoshihiro Hayakawa
NKG2D recognition and perforin effector function mediate effective cytokine immunotherapy of cancer.
The Journal of experimental medicine 2004;200(10):1325-35.
2004: Kai Sun; Lisbeth A Welniak; Angela Panoskaltsis-Mortari; Matthew J O'Shaughnessy; Haiyan Liu; Isabel Barao; William Riordan; Raquel Sitcheran; Christian Wysocki; Jonathan S Serody; Bruce R Blazar; Thomas J Sayers; William Murphy
Inhibition of acute graft-versus-host disease with retention of graft-versus-tumor effects by the proteasome inhibitor bortezomib.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):8120-5.
2004: Kazuyoshi Takeda; Noriko Yamaguchi; Hisaya Akiba; Yuko Kojima; Yoshihiro Hayakawa; Jane E Tanner; Thomas J Sayers; Naoko Seki; Ko Okumura; Hideo Yagita; Mark J Smyth
Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy.
The Journal of experimental medicine 2004;199(4):437-48.
2003: Thomas J Sayers; Alan D Brooks; Crystal Y Koh; Weihong Ma; Naoko Seki; Arati Raziuddin; Bruce R Blazar; Xia Zhang; Peter J Elliott; William Murphy
The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP.
Blood 2003;102(1):303-10.
2003: Masanobu Komatsu; Michele Mammolenti; Monica Jones; Roland Jurecic; Thomas J Sayers; Robert B Levy
Antigen-primed CD8+ T cells can mediate resistance, preventing allogeneic marrow engraftment in the simultaneous absence of perforin-, CD95L-, TNFR1-, and TRAIL-dependent killing.
Blood 2003;101(10):3991-9.
2003: Jong-Keuk Lee; Thomas J Sayers; Timothy C Back; JON WIGGINTON; Robert Wiltrout
Lack of FasL-mediated killing leads to in vivo tumor promotion in mouse Lewis lung cancer.
Apoptosis : an international journal on programmed cell death 2003;8(2):151-60.
2003: William Murphy; Lisbeth A Welniak; Timothy C Back; Julie A Hixon; Jeffrey Subleski; Naoko Seki; JON WIGGINTON; Susan E Wilson; Bruce R Blazar; Anatoli Malyguine; Thomas J Sayers; Robert Wiltrout
Synergistic anti-tumor responses after administration of agonistic antibodies to CD40 and IL-2: coordination of dendritic and CD8+ cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(5):2727-33.
2003: Naoko Seki; Yoshihiro Hayakawa; Alan D Brooks; John Wine; Robert Wiltrout; Hideo Yagita; Jane E Tanner; Mark J Smyth; Thomas J Sayers
Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer.
Cancer research 2003;63(1):207-13.
2002: Naoko Seki; Alan D Brooks; Clive R D Carter; Timothy C Back; Erin M Parsoneault; Mark J Smyth; Robert Wiltrout; Thomas J Sayers
Tumor-specific CTL kill murine renal cancer cells using both perforin and Fas ligand-mediated lysis in vitro, but cause tumor regression in vivo in the absence of perforin.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3484-92.
2001: Thomas J Sayers; Alan D Brooks; J M Ward; T Hoshino; W E Bere; G W Wiegand; Janice M Kelly; Mark J Smyth; J M Kelley
The restricted expression of granzyme M in human lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):765-71.
2000: Thomas J Sayers; Alan D Brooks; Naoko Seki; Mark J Smyth; Hideo Yagita; Bruce R Blazar; Anatoli Malyguine
T cell lysis of murine renal cancer: multiple signaling pathways for cell death via Fas.
Journal of leukocyte biology 2000;68(1):81-6.
2000: Jong-Keuk Lee; Thomas J Sayers; Alan D Brooks; Timothy C Back; Howard A Young; Kristin L Komschlies; JON WIGGINTON; Robert Wiltrout
IFN-gamma-dependent delay of in vivo tumor progression by Fas overexpression on murine renal cancer cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):231-9.
1998: Thomas J Sayers; Alan D Brooks; Jong-Keuk Lee; Robert G Fenton; Kristin L Komschlies; JON WIGGINTON; Robin Winkler-Pickett; Robert Wiltrout
Molecular mechanisms of immune-mediated lysis of murine renal cancer: differential contributions of perforin-dependent versus Fas-mediated pathways in lysis by NK and T cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(8):3957-65.
1998: Robert G Fenton; Julie A Hixon; P W Wright; Alan D Brooks; Thomas J Sayers
Inhibition of Fas (CD95) expression and Fas-mediated apoptosis by oncogenic Ras.
Cancer research 1998;58(15):3391-400.
1997: Oleg Chertov; H Ueda; L L Xu; K Tani; William Murphy; J M Wang; O M Zack Howard; Thomas J Sayers; Joost J Oppenheim
Identification of human neutrophil-derived cathepsin G and azurocidin/CAP37 as chemoattractants for mononuclear cells and neutrophils.
The Journal of experimental medicine 1997;186(5):739-47.
1996: C R Carter; Thomas J Sayers; Robert Wiltrout; SM Turcovski-Corrales; D D Taub
Generation of antigenic peptides by lymphocyte granule serine proteases (granzymes).
Cellular immunology 1996;172(2):235-45.
1996: Thomas J Sayers; A R Lloyd; Daniel W McVicar; M D O'Connor; J M Kelly; C R Carter; TA Wiltrout; Robert Wiltrout; Mark J Smyth
Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3.
Journal of leukocyte biology 1996;59(5):763-8.
1995: D D Taub; Thomas J Sayers; C R Carter; John R Ortaldo
Alpha and beta chemokines induce NK cell migration and enhance NK-mediated cytolysis.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(8):3877-88.
1995: J L Franco; P Ghosh; Robert Wiltrout; C R Carter; Arnold H Zea; N Momozaki; Augusto C Ochoa; Dan Longo; Thomas J Sayers; Kristin L Komschlies
Partial degradation of T-cell signal transduction molecules by contaminating granulocytes during protein extraction of splenic T cells from tumor-bearing mice.
Cancer research 1995;55(17):3840-6.
1995: John R Ortaldo; TA Wiltrout; Thomas J Sayers; H Yagita; Robin Winkler-Pickett
Characterization of a non-granule associated pore-forming protein in agranular lymphocytes.
Journal of leukocyte biology 1995;57(6):897-903.
1995: Mark J Smyth; Mark D Hulett; K Y Thia; H A Young; Thomas J Sayers; C R Carter; Joseph A Trapani
Cloning and characterization of a novel NK cell-specific serine protease gene and its functional 5'-flanking sequences.
Immunogenetics 1995;42(2):101-11.
1994: A M Pilaro; D D Taub; K L McCormick; H M Williams; Thomas J Sayers; William E Fogler; Robert Wiltrout
TNF-alpha is a principal cytokine involved in the recruitment of NK cells to liver parenchyma.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(1):333-42.
1994: K Kaneda; A M Pilaro; Thomas J Sayers; K Nagashima; M A Gonda; John R Ortaldo; Robert Wiltrout
Quantitative analysis of rod-cored vesicles and dense granules of large granular lymphocytes in the liver, spleen, and peripheral blood of rats.
Cell and tissue research 1994;276(1):187-95.
1994: Martin MacPhee; Robert Wiltrout; K L McCormick; Thomas J Sayers; A M Pilaro
A method for obtaining and culturing large numbers of purified organ-derived murine endothelial cells.
Journal of leukocyte biology 1994;55(4):467-75.
1994: Thomas J Sayers; TA Wiltrout; Mark J Smyth; K S Ottaway; A M Pilaro; R Sowder; Louis E. Henderson; Hans Sprenger; A R Lloyd
Purification and cloning of a novel serine protease, RNK-Tryp-2, from the granules of a rat NK cell leukemia.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(5):2289-97.
1993: Mark J Smyth; Thomas J Sayers; TA Wiltrout; James C Powers; Joseph A Trapani
Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(11):6195-205.
1993: William Murphy; T C Back; K C Conlon; Kristin L Komschlies; John R Ortaldo; Thomas J Sayers; Robert Wiltrout; Dan Longo
Antitumor effects of interleukin-7 and adoptive immunotherapy on human colon carcinoma xenografts.
The Journal of clinical investigation 1993;92(4):1918-24.
1993: William Murphy; K C Conlon; Thomas J Sayers; Robert Wiltrout; T C Back; John R Ortaldo; Dan Longo
Engraftment and activity of anti-CD3-activated human peripheral blood lymphocytes transferred into mice with severe combined immune deficiency.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(8 Pt 1):3634-42.
1993: Thomas J Sayers; L H Mason; A Pilaro; TA Wiltrout; Kristin L Komschlies; W L Munger; Robert Wiltrout
Substrate-specific proteases (BLT-esterase) are localized predominantly in the natural killer cells of unprimed mice.
Journal of leukocyte biology 1993;53(4):454-61.
1992: Mark J Smyth; TA Wiltrout; Joseph A Trapani; K S Ottaway; R Sowder; Louis E. Henderson; C M Kam; James C Powers; H A Young; Thomas J Sayers
Purification and cloning of a novel serine protease, RNK-Met-1, from the granules of a rat natural killer cell leukemia.
The Journal of biological chemistry 1992;267(34):24418-25.
1992: Thomas J Sayers; TA Wiltrout; R Sowder; W L Munger; Mark J Smyth; Louis E. Henderson
Purification of a factor from the granules of a rat natural killer cell line (RNK) that reduces tumor cell growth and changes tumor morphology. Molecular identity with a granule serine protease (RNKP-1).
Journal of immunology (Baltimore, Md. : 1950) 1992;148(1):292-300.
1990: A M Pilaro; Thomas J Sayers; K L McCormick; C W Reynolds; Robert Wiltrout
An improved in vitro assay to quantitate chemotaxis of rat peripheral blood large granular lymphocytes (LGL).
Journal of immunological methods 1990;135(1-2):213-23.
1990: Thomas J Sayers; TA Wiltrout; K McCormick; C Husted; Robert Wiltrout
Antitumor effects of alpha-interferon and gamma-interferon on a murine renal cancer (Renca) in vitro and in vivo.
Cancer research 1990;50(17):5414-20.
1990: Thomas J Sayers; L H Mason; TA Wiltrout
Trafficking and activation of murine natural killer cells: differing roles for IFN-gamma and IL-2.
Cellular immunology 1990;127(2):311-26.
1988: Thomas J Sayers; TA Wiltrout; C A Bull; A C Denn; A M Pilaro; B Lokesh
Effect of cytokines on polymorphonuclear neutrophil infiltration in the mouse. Prostaglandin- and leukotriene-independent induction of infiltration by IL-1 and tumor necrosis factor.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(5):1670-7.
1986: Thomas J Sayers; J H Ransom; A C Denn; R B Herberman; John R Ortaldo
Analysis of a cytostatic lymphokine produced by incubation of lymphocytes with tumor cells: relationship to leukoregulin and distinction from recombinant lymphotoxin, recombinant tumor necrosis factor, and natural killer cytotoxic factor.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(1):385-90.