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Lawrence Sayre

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Xiongwei Zhu; Gjumrakch Aliev; Rudy J Castellani; Hisashi Fujioka; Peggy L R Harris; Paula I Moreira; Lawrence M Sayre; Justin Shenk; Sandra L Siedlak; Mark A Smith; Luke I Szweda; Pamela A Szweda; George Perry
Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover.
Xiaoxia Tang; Lawrence M Sayre; Gregory P Tochtrop
A mass spectrometric analysis of 4-hydroxy-2-(E)-nonenal modification of cytochrome c.
Xiaochun Zhu; Xiaoxia Tang; Jianye Zhang; Gregory P Tochtrop; Vernon E Anderson; Lawrence M Sayre
Mass spectrometric evidence for the existence of distinct modifications of different proteins by 2(E),4(E)-decadienal.

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2012: Xiongwei Zhu; Gjumrakch Aliev; Rudy J Castellani; Hisashi Fujioka; Peggy L R Harris; Paula I Moreira; Lawrence M Sayre; Justin Shenk; Sandra L Siedlak; Mark A Smith; Luke I Szweda; Pamela A Szweda; George Perry
Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover.
Free radical biology & medicine 2012;52(3):699-704.
2011: Xiaoxia Tang; Lawrence M Sayre; Gregory P Tochtrop
A mass spectrometric analysis of 4-hydroxy-2-(E)-nonenal modification of cytochrome c.
Journal of mass spectrometry : JMS 2011;46(3):290-7.
2010: Xiaochun Zhu; Xiaoxia Tang; Jianye Zhang; Gregory P Tochtrop; Vernon E Anderson; Lawrence M Sayre
Mass spectrometric evidence for the existence of distinct modifications of different proteins by 2(E),4(E)-decadienal.
Chemical research in toxicology 2010;23(3):467-73.
2010: Detao Gao; Mohammad Z Ashraf; Niladri S Kar; De Lin; Lawrence M Sayre; Eugene A Podrez
Structural basis for the recognition of oxidized phospholipids in oxidized low density lipoproteins by class B scavenger receptors CD36 and SR-BI.
The Journal of biological chemistry 2010;285(7):4447-54.
2009: Xiaochun Zhu; Xiaoxia Tang; Vernon E Anderson; Lawrence M Sayre
Mass spectrometric characterization of protein modification by the products of nonenzymatic oxidation of linoleic acid.
Chemical research in toxicology 2009;22(8):1386-97.
2009: Xiaochun Zhu; Vernon E Anderson; Lawrence M Sayre
Charge-derivatized amino acids facilitate model studies on protein side-chain modifications by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Rapid communications in mass spectrometry : RCM 2009;23(14):2113-24.
2009: Xiaochun Zhu; Molly M Gallogly; John J Mieyal; Vernon E Anderson; Lawrence M Sayre
Covalent cross-linking of glutathione and carnosine to proteins by 4-oxo-2-nonenal.
Chemical research in toxicology 2009;22(6):1050-9.
2009: Hyun-Pil Lee; Xiongwei Zhu; Xiaochun Zhu; S Chad Skidmore; George Perry; Lawrence M Sayre; Mark A. Smith; Hyoung-gon Lee
The essential role of ERK in 4-oxo-2-nonenal-mediated cytotoxicity in SH-SY5Y human neuroblastoma cells.
Journal of neurochemistry 2009;108(6):1434-41.
2009: Ke-Qing Ling; Lawrence M Sayre
Discovery of a sensitive, selective, and tightly binding fluorogenic substrate of bovine plasma amine oxidase.
The Journal of organic chemistry 2009;74(1):339-50.
2008: Ke-Qing Ling; Wen-Shan Li; Lawrence M Sayre
Oxidations of N-(3-indoleethyl) cyclic aliphatic amines by horseradish peroxidase: the indole ring binds to the enzyme and mediates electron-transfer amine oxidation.
Journal of the American Chemical Society 2008;130(3):933-44.
2008: Lawrence M Sayre; George Perry; Mark A. Smith
Oxidative stress and neurotoxicity.
Chemical research in toxicology 2008;21(1):172-88.
2007: De Lin; Jianye Zhang; Lawrence M Sayre
Synthesis of six epoxyketooctadecenoic acid (EKODE) isomers, their generation from nonenzymatic oxidation of linoleic acid, and their reactivity with imidazole nucleophiles.
The Journal of organic chemistry 2007;72(25):9471-80.
2007: Yuming Zhang; Chongzhao Ran; Guangyin Zhou; Lawrence M Sayre
Highly potent 3-pyrroline mechanism-based inhibitors of bovine plasma amine oxidase and mass spectrometric confirmation of cofactor derivatization.
Bioorganic & medicinal chemistry 2007;15(4):1868-77.
2007: Xiaochun Zhu; Lawrence M Sayre
Long-lived 4-oxo-2-enal-derived apparent lysine michael adducts are actually the isomeric 4-ketoamides.
Chemical research in toxicology 2007;20(2):165-70.
2007: Xiaochun Zhu; Lawrence M Sayre
Mass spectrometric evidence for long-lived protein adducts of 4-oxo-2-nonenal.
Redox report : communications in free radical research 2007;12(1):45-9.
2007: Quan Yuan; Xiaochun Zhu; Lawrence M Sayre
Chemical nature of stochastic generation of protein-based carbonyls: metal-catalyzed oxidation versus modification by products of lipid oxidation.
Chemical research in toxicology 2007;20(1):129-39.
2006: Chunhua Qiao; Ke-Qing Ling; Eric M Shepard; David M Dooley; Lawrence M Sayre
Mechanism-based cofactor derivatization of a copper amine oxidase by a branched primary amine recruits the oxidase activity of the enzyme to turn inactivator into substrate.
Journal of the American Chemical Society 2006;128(18):6206-19.
2006: Jisook Kim; Yuming Zhang; Chongzhao Ran; Lawrence M Sayre
Inactivation of bovine plasma amine oxidase by haloallylamines.
Bioorganic & medicinal chemistry 2006;14(5):1444-53.
2006: Shivaprakash Puttaiah; Yuming Zhang; Heather A Pilch; Christoph Pfahler; Tomoko Oya-Ito; Lawrence M Sayre; Ram H Nagaraj
Detection of dideoxyosone intermediates of glycation using a monoclonal antibody: characterization of major epitope structures.
Archives of biochemistry and biophysics 2006;446(2):186-96.
2006: Lawrence M Sayre; De Lin; Quan Yuan; Xiaochun Zhu; Xiaoxia Tang
Protein adducts generated from products of lipid oxidation: focus on HNE and one.
Drug metabolism reviews 2006;38(4):651-75.
2005: De Lin; Hyoung-gon Lee; Quan Liu; George Perry; Mark A. Smith; Lawrence M Sayre
4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal.
Chemical research in toxicology 2005;18(8):1219-31.
2005: Ke-Qing Ling; Lawrence M Sayre
Horseradish peroxidase-mediated aerobic and anaerobic oxidations of 3-alkylindoles.
Bioorganic & medicinal chemistry 2005;13(10):3543-51.
2005: Ke-Qing Ling; Lawrence M Sayre
A dopaquinone model that mimics the water addition step of cofactor biogenesis in copper amine oxidases.
Journal of the American Chemical Society 2005;127(13):4777-84.
2005: Quan Liu; Mark A. Smith; Jesús Avila; John DeBernardis; Mayank M Kansal; Atsushi Takeda; Xiongwei Zhu; Akihiko Nunomura; Kazuhiro Honda; Paula I Moreira; Catarina R Oliveira; Maria S Santos; Shun Shimohama; Gjumrakch Aliev; Jack C. de la Torre; Hossein A Ghanbari; Sandra L Siedlak; Peggy L R Harris; Lawrence M Sayre; George Perry
Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations.
Free radical biology & medicine 2005;38(6):746-54.
2005: Subrata Mandal; Najam H Kazmi; Lawrence M Sayre
Ligand dependence in the copper-catalyzed oxidation of hydroquinones.
Archives of biochemistry and biophysics 2005;435(1):21-31.
2005: Tianyun Wu; Ke-Qing Ling; Lawrence M Sayre; William S McIntire
Inhibition of murine N1-acetylated polyamine oxidase by an acetylenic amine and the allenic amine, MDL 72527.
Biochemical and biophysical research communications 2005;326(2):483-90.
2005: Lawrence M Sayre; Paula I Moreira; Mark A. Smith; George Perry
Metal ions and oxidative protein modification in neurological disease.
Annali dell'Istituto superiore di sanità 2005;41(2):143-64.
2004: Kimberly M O'Connell; David B Langley; Eric M Shepard; Anthony P Duff; Heung-Bae Jeon; Gang Sun; Hans C Freeman; J Mitchell Guss; Lawrence M Sayre; David M Dooley
Differential inhibition of six copper amine oxidases by a family of 4-(aryloxy)-2-butynamines: evidence for a new mode of inactivation.
Biochemistry 2004;43(34):10965-78.
2004: Chunhua Qiao; Heung-Bae Jeon; Lawrence M Sayre
Selective inhibition of bovine plasma amine oxidase by homopropargylamine, a new inactivator motif.
Journal of the American Chemical Society 2004;126(25):8038-45.
2004: Lawrence M Sayre; Peggy L R Harris; George Perry; Mark A Smith
In situ localization of nonenzymatic peroxidase-like activity of tissue-bound transition metals.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2004;Chapter 17():Unit17.4.
2004: Eric M Shepard; Gregory A Juda; Ke-Qing Ling; Lawrence M Sayre; David M Dooley
Cyanide as a copper and quinone-directed inhibitor of amine oxidases from pea seedlings ( Pisum sativum) and Arthrobacter globiformis: evidence for both copper coordination and cyanohydrin derivatization of the quinone cofactor.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(3):256-68.
2004: Craig S Atwood; George Perry; Hong Zeng; Yoji Kato; Walton D Jones; Ke-Qing Ling; Xudong Huang; Robert D. Moir; Dandan Wang; Lawrence M Sayre; Mark A. Smith; Shu G Chen; Ashley I Bush
Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta.
Biochemistry 2004;43(2):560-8.
2004: Zhongfa Liu; Paul E Minkler; De Lin; Lawrence M Sayre
Derivatization of amino acids with N,N-dimethyl-2,4-dinitro-5-fluorobenzylamine for liquid chromatography/electrospray ionization mass spectrometry.
Rapid communications in mass spectrometry : RCM 2004;18(10):1059-65.
2004: Yahua Liu; Gang Sun; Adrian David; Lawrence M Sayre
Model studies on the metal-catalyzed protein oxidation: structure of a possible His-Lys cross-link.
Chemical research in toxicology 2004;17(1):110-8.
2003: Yahua Liu; Guozhang Xu; Lawrence M Sayre
Carnosine inhibits (E)-4-hydroxy-2-nonenal-induced protein cross-linking: structural characterization of carnosine-HNE adducts.
Chemical research in toxicology 2003;16(12):1589-97.
2003: Heung-Bae Jeon; Younghee Lee; Chunhua Qiao; He Huang; Lawrence M Sayre
Inhibition of bovine plasma amine oxidase by 1,4-diamino-2-butenes and -2-butynes.
Bioorganic & medicinal chemistry 2003;11(21):4631-41.
2003: Quan Liu; Arun K Raina; Mark A. Smith; Lawrence M Sayre; George Perry
Hydroxynonenal, toxic carbonyls, and Alzheimer disease.
Molecular aspects of medicine 2003;24(4-5):305-13.
2003: Zhongfa Liu; Paul E Minkler; Lawrence M Sayre
Mass spectroscopic characterization of protein modification by 4-hydroxy-2-(E)-nonenal and 4-oxo-2-(E)-nonenal.
Chemical research in toxicology 2003;16(7):901-11.
2003: Heung-Bae Jeon; Lawrence M Sayre
Highly potent propargylamine and allylamine inhibitors of bovine plasma amine oxidase.
Biochemical and biophysical research communications 2003;304(4):788-94.
2003: Heung-Bae Jeon; Gang Sun; Lawrence M Sayre
Inactivation of bovine plasma amine oxidase by 4-aryloxy-2-butynamines and related analogs.
Biochimica et biophysica acta 2003;1647(1-2):343-54.
2003: Wei-Han Zhang; Jiyun Liu; Guozhang Xu; Quan Yuan; Lawrence M Sayre
Model studies on protein side chain modification by 4-oxo-2-nonenal.
Chemical research in toxicology 2003;16(4):512-23.
2003: Ke-Qing Ling; Younghee Lee; Dainius Macikenas; John D Protasiewicz; Lawrence M Sayre
Copper(II)-mediated autoxidation of tert-butylresorcinols.
The Journal of organic chemistry 2003;68(4):1358-66.
2003: Zhongfa Liu; Lawrence M Sayre
Model studies on the modification of proteins by lipoxidation-derived 2-hydroxyaldehydes.
Chemical research in toxicology 2003;16(2):232-41.
2002: George Perry; Akihiko Nunomura; Keisuke Hirai; Xiongwei Zhu; Mar Pérez; Jesús Avila; Rudy J Castellani; Craig S Atwood; Gjumrakch Aliev; Lawrence M Sayre; Atsushi Takeda; Mark A. Smith
Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?
Free radical biology & medicine 2002;33(11):1475-9.
2002: Younghee Lee; Ke-Qing Ling; Xingliang Lu; Richard B Silverman; Eric M Shepard; David M Dooley; Lawrence M Sayre
3-pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases.
Journal of the American Chemical Society 2002;124(41):12135-43.
2002: Eric M Shepard; Jennifer Smith; Bradley O Elmore; Jason A Kuchar; Lawrence M Sayre; David M Dooley
Towards the development of selective amine oxidase inhibitors. Mechanism-based inhibition of six copper containing amine oxidases.
European journal of biochemistry / FEBS 2002;269(15):3645-58.
2002: Guozhang Xu; Lawrence M Sayre
Cross-linking of proteins by 3-(trifluoromethyl)-2,5-hexanedione. Model studies implicate an unexpected amine-dependent defluorinative substitution pathway competing with pyrrole formation.
The Journal of organic chemistry 2002;67(9):3007-14.
2002: Mark A. Smith; Kelly L Drew; Akihiko Nunomura; Atsushi Takeda; Keisuke Hirai; Xiongwei Zhu; Craig S Atwood; Arun K Raina; Catherine A Rottkamp; Lawrence M Sayre; Robert P Friedland; George Perry
Amyloid-beta, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs?
Neurochemistry international 2002;40(6):527-31.
2002: Takafumi Wataya; Akihiko Nunomura; Mark A. Smith; Sandra L Siedlak; Peggy L R Harris; Shun Shimohama; Luke I Szweda; Matthew A Kaminski; Jesús Avila; Donald L Price; Don W Cleveland; Lawrence M Sayre; George Perry
High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal.
The Journal of biological chemistry 2002;277(7):4644-8.
2002: Rudy J Castellani; George Perry; Sandra L Siedlak; Akihiko Nunomura; Shun Shimohama; Jing Zhang; Thomas J Montine; Lawrence M Sayre; Mark A. Smith
Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans.
Neuroscience letters 2002;319(1):25-8.
2002: George Perry; Lawrence M Sayre; Craig S Atwood; Rudy J Castellani; Adam D Cash; Catherine A Rottkamp; Mark A. Smith
The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications.
CNS drugs 2002;16(5):339-52.
2001: Ke-Qing Ling; J Kim; Lawrence M Sayre
Catalytic turnover of benzylamine by a model for the lysine tyrosylquinone (LTQ) cofactor of lysyl oxidase.
Journal of the American Chemical Society 2001;123(39):9606-11.
2001: Rudy J Castellani; Peggy L R Harris; Lawrence M Sayre; J Fujii; N Taniguchi; Michael P. Vitek; H Founds; Craig S Atwood; George Perry; Mark A. Smith
Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine.
Free radical biology & medicine 2001;31(2):175-80.
2001: Lawrence M Sayre; Mark A. Smith; George Perry
Chemistry and biochemistry of oxidative stress in neurodegenerative disease.
Current medicinal chemistry 2001;8(7):721-38.
2001: Arezoo Campbell; Mark A. Smith; Lawrence M Sayre; Stephen C Bondy; George Perry
Mechanisms by which metals promote events connected to neurodegenerative diseases.
Brain research bulletin 2001;55(2):125-32.
2001: Younghee Lee; Heung-Bae Jeon; H Huang; Lawrence M Sayre
Temporary inactivation of plasma amine oxidase by alkylhydrazines. A combined enzyme/model study implicates cofactor reduction/reoxidation but cofactor deoxygenation and subsequent reoxygenation in the case of hydrazine itself.
The Journal of organic chemistry 2001;66(6):1925-37.
2001: Guozhang Xu; M P Singh; D Gopal; Lawrence M Sayre
Novel 2,5-hexanedione analogues. Substituent-induced control of the protein cross-linking potential and oxidation susceptibility of the resulting primary amine-derived pyrroles.
Chemical research in toxicology 2001;14(3):264-74.
2001: Younghee Lee; Eric M Shepard; J Smith; David M Dooley; Lawrence M Sayre
Catalytic turnover of substrate benzylamines by the quinone-dependent plasma amine oxidase leads to H2O2-dependent inactivation: evidence for generation of a cofactor-derived benzoxazole.
Biochemistry 2001;40(3):822-9.
2000: Eugene A Podrez; George Hoppe; June O'Neil; Lawrence M Sayre; Nader Sheibani; Henry F Hoff
Macrophage receptors responsible for distinct recognition of low density lipoprotein containing pyrrole or pyridinium adducts: models of oxidized low density lipoprotein.
Journal of lipid research 2000;41(9):1455-63.
2000: Atsushi Takeda; Mark A. Smith; Jesús Avila; Akihiko Nunomura; Sandra L Siedlak; Xiongwei Zhu; George Perry; Lawrence M Sayre
In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification.
Journal of neurochemistry 2000;75(3):1234-41.
2000: Catherine A Rottkamp; Akihiko Nunomura; Keisuke Hirai; Lawrence M Sayre; George Perry; Mark A. Smith
Will antioxidants fulfill their expectations for the treatment of Alzheimer disease?
Mechanisms of ageing and development 2000;116(2-3):169-79.
2000: Robert G Salomon; K Kaur; Eugene A Podrez; Henry F Hoff; A V Krushinsky; Lawrence M Sayre
HNE-derived 2-pentylpyrroles are generated during oxidation of LDL, are more prevalent in blood plasma from patients with renal disease or atherosclerosis, and are present in atherosclerotic plaques.
Chemical research in toxicology 2000;13(7):557-64.
2000: Lawrence M Sayre; George Perry; Craig S Atwood; Mark A. Smith
The role of metals in neurodegenerative diseases.
Cellular and molecular biology (Noisy-le-Grand, France) 2000;46(4):731-41.
2000: Guozhang Xu; Yahua Liu; Lawrence M Sayre
Polyclonal antibodies to a fluorescent 4-hydroxy-2-nonenal (HNE)-derived lysine-lysine cross-link: characterization and application to HNE-treated protein and in vitro oxidized low-density lipoprotein.
Chemical research in toxicology 2000;13(5):406-13.
2000: George Perry; Arun K Raina; Akihiko Nunomura; Takafumi Wataya; Lawrence M Sayre; Mark A. Smith
How important is oxidative damage? Lessons from Alzheimer's disease.
Free radical biology & medicine 2000;28(5):831-4.
2000: Arun K Raina; George Perry; Akihiko Nunomura; Lawrence M Sayre; Mark A. Smith
Histochemical and immunocytochemical approaches to the study of oxidative stress.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2000;38(2):93-7.
2000: Catherine A Rottkamp; Akihiko Nunomura; Arun K Raina; Lawrence M Sayre; George Perry; Mark A. Smith
Oxidative stress, antioxidants, and Alzheimer disease.
Alzheimer disease and associated disorders 2000;14 Suppl 1():S62-6.
2000: Lawrence M Sayre; George Perry; Peggy L R Harris; Y Liu; K A Schubert; Mark A. Smith
In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals.
Journal of neurochemistry 2000;74(1):270-9.
1999: Edward L Kean; Z Wei; Vernon E Anderson; N Zhang; Lawrence M Sayre
Regulation of the biosynthesis of N-acetylglucosaminylpyrophosphoryldolichol, feedback and product inhibition.
The Journal of biological chemistry 1999;274(48):34072-82.
1999: Guozhang Xu; Lawrence M Sayre
Structural elucidation of a 2:2 4-ketoaldehyde-amine adduct as a model for lysine-directed cross-linking of proteins by 4-ketoaldehydes.
Chemical research in toxicology 1999;12(9):862-8.
1999: Guozhang Xu; Yahua Liu; Mayank M Kansal; Lawrence M Sayre
Rapid cross-linking of proteins by 4-ketoaldehydes and 4-hydroxy-2-alkenals does not arise from the lysine-derived monoalkylpyrroles.
Chemical research in toxicology 1999;12(9):855-61.
1999: Lawrence M Sayre; George Perry; Mark A. Smith
Redox metals and neurodegenerative disease.
Current opinion in chemical biology 1999;3(2):220-5.
1999: Lawrence M Sayre; George Perry; Mark A. Smith
In situ methods for detection and localization of markers of oxidative stress: application in neurodegenerative disorders.
Methods in enzymology 1999;309():133-52.
1998: Younghee Lee; Lawrence M Sayre
Reaffirmation that metabolism of polyamines by bovine plasma amine oxidase occurs strictly at the primary amino termini.
The Journal of biological chemistry 1998;273(31):19490-4.
1998: Rajesh N. Kalaria; DR Premkumar; C W Lin; S N Kroon; J Y Bae; Lawrence M Sayre; Joseph C LaManna
Identification and expression of the Na+/H+ exchanger in mammalian cerebrovascular and choroidal tissues: characterization by amiloride-sensitive [3H]MIA binding and RT-PCR analysis.
Brain research. Molecular brain research 1998;58(1-2):178-87.
1998: Mark A. Smith; Lawrence M Sayre; V E Anderson; P L Harris; M Flint Beal; Neil W Kowall; George Perry
Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1998;46(6):731-5.
1998: Guozhang Xu; Lawrence M Sayre
Structural characterization of a 4-hydroxy-2-alkenal-derived fluorophore that contributes to lipoperoxidation-dependent protein cross-linking in aging and degenerative disease.
Chemical research in toxicology 1998;11(4):247-51.
1998: Rudy J Castellani; George Perry; Peggy L R Harris; M L Cohen; Lawrence M Sayre; R G Salomon; Mark A. Smith
Advanced lipid peroxidation end-products in Alexander's disease.
Brain research 1998;787(1):15-8.
1997: George Hoppe; June O'Neil; Lawrence M Sayre; Henry F Hoff
Non-conventional modification of low density lipoproteins: chemical models for macrophage recognition of oxidized LDL.
Biochimica et biophysica acta 1997;1362(2-3):103-8.
1997: Mark A. Smith; P L Harris; Lawrence M Sayre; George Perry
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(18):9866-8.
1997: D Gopal; D Macikenas; Lawrence M Sayre; John D Protasiewicz
Structural determination of a dimeric side-product accompanying dihydropyrazine preparation.
Acta chemica Scandinavica (Copenhagen, Denmark : 1989) 1997;51(9):938-41.
1997: Lawrence M Sayre; Michael G Zagorski; Witold K Surewicz; G A Krafft; George Perry
Mechanisms of neurotoxicity associated with amyloid beta deposition and the role of free radicals in the pathogenesis of Alzheimer's disease: a critical appraisal.
Chemical research in toxicology 1997;10(5):518-26.
1997: Lawrence M Sayre; D A Zelasko; Peggy L R Harris; George Perry; Robert G Salomon; Mark A. Smith
4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease.
Journal of neurochemistry 1997;68(5):2092-7.
1997: Mark A. Smith; P L Richey Harris; Lawrence M Sayre; J S Beckman; George Perry
Widespread peroxynitrite-mediated damage in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(8):2653-7.
1997: Lawrence M Sayre; D A Engelhart; D V Nadkarni; M K Manoj Babu; A M Flammang; G D McCoy
The role of iminium-enamine species in the toxication and detoxication of cyclic tertiary amines.
NIDA research monograph 1997;173():106-27.
1997: Lawrence M Sayre; Pierluigi Gambetti
Mechanistic importance of axonal atrophy and swelling in gamma-diketone axonopathy: commentary on forum position paper.
Neurotoxicology 1997;18(1):31-2; discussion 37-40.
1997: June O'Neil; George Hoppe; Lawrence M Sayre; Henry F Hoff
Inactivation of cathepsin B by oxidized LDL involves complex formation induced by binding of putative reactive sites exposed at low pH to thiols on the enzyme.
Free radical biology & medicine 1997;23(2):215-25.
1996: Lawrence M Sayre; Wei Sha; Guozhang Xu; K Kaur; D Nadkarni; Ganesamoorthy Subbanagounder; Robert G Salomon
Immunochemical evidence supporting 2-pentylpyrrole formation on proteins exposed to 4-hydroxy-2-nonenal.
Chemical research in toxicology 1996;9(7):1194-201.
1996: Lawrence M Sayre; R T Naismith; M A Bada; W S Li; M E Klein; M D Tennant
trans-2-phenylcyclopropylamine is a substrate for and inactivator of horseradish peroxidase.
Biochimica et biophysica acta 1996;1296(2):250-6.
1996: C W Lin; Rajesh N. Kalaria; S N Kroon; J Y Bae; Lawrence M Sayre; Joseph C LaManna
The amiloride-sensitive Na+/H+ exchange antiporter and control of intracellular pH in hippocampal brain slices.
Brain research 1996;731(1-2):108-13.
1996: Mark A. Smith; George Perry; P L Richey; Lawrence M Sayre; V E Anderson; M Flint Beal; Neil W Kowall
Oxidative damage in Alzheimer's.
Nature 1996;382(6587):120-1.
1996: Mark A. Smith; Lawrence M Sayre; Vincent M Monnier; George Perry
Oxidative posttranslational modifications in Alzheimer disease. A possible pathogenic role in the formation of senile plaques and neurofibrillary tangles.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1996;28(1-3):41-8.
1996: Mark A. Smith; Lawrence M Sayre; George Perry
Diabetes mellitus and Alzheimer's disease: glycation as a biochemical link.
Diabetologia 1996;39(2):247.
1995: Z He; D V Nadkarni; Lawrence M Sayre; Frederick T Greenaway
Mechanism-based inactivation of porcine kidney diamine oxidase by 1,4-diamino-2-butene.
Biochimica et biophysica acta 1995;1253(1):117-27.
1995: Mark A. Smith; V M Monnier; Lawrence M Sayre; George Perry
Amyloidosis, advanced glycation end products and Alzheimer disease.
Neuroreport 1995;6(12):1595-6.
1995: Lawrence M Sayre; D A Engelhart; D V Nadkarni; M K Babu; M E Klein; G McCoy
Haemoprotein-mediated metabolism of enamines and the possible involvement of one-electron oxidations.
Xenobiotica; the fate of foreign compounds in biological systems 1995;25(7):769-75.
1995: Mark A. Smith; M Rudnicka-Nawrot; P L Richey; D Praprotnik; P Mulvihill; C A Miller; Lawrence M Sayre; George Perry
Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease.
Journal of neurochemistry 1995;64(6):2660-6.
1995: Mark A. Smith; Lawrence M Sayre; V M Monnier; George Perry
Radical AGEing in Alzheimer's disease.
Trends in neurosciences 1995;18(4):172-6.
1995: Mark A. Smith; Lawrence M Sayre; Michael P. Vitek; V M Monnier; George Perry
Early AGEing and Alzheimer's.
Nature 1995;374(6520):316.
1995: D V Nadkarni; Lawrence M Sayre
Structural definition of early lysine and histidine adduction chemistry of 4-hydroxynonenal.
Chemical research in toxicology 1995;8(2):284-91.
1995: Lawrence M Sayre; Y Lee
Catalytic aerobic deamination of activated primary amines by a model for the quinone cofactor of mammalian copper amine oxidases.
Methods in enzymology 1995;258():53-69.
1994: Mark A. Smith; P L Richey; S Taneda; R K Kutty; Lawrence M Sayre; Vincent M Monnier; George Perry
Advanced Maillard reaction end products, free radicals, and protein oxidation in Alzheimer's disease.
Annals of the New York Academy of Sciences 1994;738():447-54.
1994: J Talafous; Lawrence M Sayre; John J Mieyal; Gilles Klopman
META. 2. A dictionary model of mammalian xenobiotic metabolism.
Journal of chemical information and computer sciences 1994;34(6):1326-33.
1994: Mark A. Smith; S Taneda; P L Richey; S Miyata; Shi Du Yan; D Stern; Lawrence M Sayre; Vincent M Monnier; George Perry
Advanced Maillard reaction end products are associated with Alzheimer disease pathology.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5710-4.
1994: B Bacci; E Cochran; M G Nunzi; E Izeki; T Mizutani; A Patton; S Hite; Lawrence M Sayre; L Autilio-Gambetti; Pierluigi Gambetti
Amyloid beta precursor protein and ubiquitin epitopes in human and experimental dystrophic axons. Ultrastructural localization.
The American journal of pathology 1994;144(4):702-10.
1993: Sami I Harik; N J Riachi; M A Hritz; Marc S Berridge; Lawrence M Sayre
Development of fluorinated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs with potent nigrostriatal toxicity for potential use in positron emission tomography studies.
The Journal of pharmacology and experimental therapeutics 1993;266(2):790-5.
1993: Marc S Berridge; Lawrence M Sayre; P K Arora; A H Terris; N J Riachi; Sami I Harik
Design and synthesis of 18F-labeled neurotoxic analogs of MPTP.
Journal of medicinal chemistry 1993;36(9):1284-90.
1993: Lawrence M Sayre; P K Arora; R S Iyer; Robert G Salomon
Pyrrole formation from 4-hydroxynonenal and primary amines.
Chemical research in toxicology 1993;6(1):19-22.
1991: Lawrence M Sayre; F J Wang; P K Arora; N J Riachi; Sami I Harik; Charles L Hoppel
Dopaminergic neurotoxicity in vivo and inhibition of mitochondrial respiration in vitro by possible endogenous pyridinium-like substances.
Journal of neurochemistry 1991;57(6):2106-15.
1991: Lawrence M Sayre; D A Engelhart; B Venkataraman; M K Babu; G D McCoy
Generation and fate of enamines in the microsomal metabolism of cyclic tertiary amines.
Biochemical and biophysical research communications 1991;179(3):1368-76.
1991: A R Jacobson; S W Tam; Lawrence M Sayre
Modification of the enkephalin "message" with an artificial polycationic C-terminus.
Journal of medicinal chemistry 1991;34(9):2816-21.
1991: M P Singh; F J Wang; Charles L Hoppel; Lawrence M Sayre
Inhibition of mitochondrial respiration by neutral, monocationic, and dicationic bis-pyridines related to the dopaminergic neurotoxin 1-methyl-4-phenylpyridinium cation (MPP+).
Archives of biochemistry and biophysics 1991;286(1):138-46.
1990: Lawrence M Sayre; M P Singh; P K Arora; F Wang; R J McPeak; Charles L Hoppel
Inhibition of mitochondrial respiration by analogues of the dopaminergic neurotoxin 1-methyl-4-phenylpyridinium: structural requirements for accumulation-dependent enhanced inhibitory potency on intact mitochondria.
Archives of biochemistry and biophysics 1990;280(2):274-83.
1990: S Monaco; T Wongmongkolrit; C M Shearson; A Patton; B Schaetzle; L Autilio-Gambetti; Pierluigi Gambetti; Lawrence M Sayre
Giant axonopathy characterized by intermediate location of axonal enlargements and acceleration of neurofilament transport.
Brain research 1990;519(1-2):73-81.
1990: P K Arora; N J Riachi; G C Fiedler; M P Singh; F Abdallah; Sami I Harik; Lawrence M Sayre
Structure-neurotoxicity trends of analogues of 1-methyl-4-phenylpyridinium (MPP+), the cytotoxic metabolite of the dopaminergic neurotoxin MPTP.
Life sciences 1990;46(5):379-90.
1989: A R Jacobson; A R Gintzler; Lawrence M Sayre
Minimum-structure enkephalin analogues incorporating L-tyrosine, D(or L)-phenylalanine, and a diamine spacer.
Journal of medicinal chemistry 1989;32(8):1708-17.
1989: Lawrence M Sayre
Biochemical mechanism of action of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Toxicology letters 1989;48(2):121-49.
1989: Lawrence M Sayre; F Wang; Charles L Hoppel
Tetraphenylborate potentiates the respiratory inhibition by the dopaminergic neurotoxin MPP+ in both electron transport particles and intact mitochondria.
Biochemical and biophysical research communications 1989;161(2):809-18.
1988: B E Ehrlich; A R Jacobson; R Hinrichsen; Lawrence M Sayre; Michael Forte
Paramecium calcium channels are blocked by a family of calmodulin antagonists.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(15):5718-22.
1988: P K Arora; N J Riachi; Sami I Harik; Lawrence M Sayre
Chemical oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its in vivo metabolism in rat brain and liver.
Biochemical and biophysical research communications 1988;152(3):1339-47.
1988: N J Riachi; P K Arora; Lawrence M Sayre; Sami I Harik
Potent neurotoxic fluorinated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs as potential probes in models of Parkinson disease.
Journal of neurochemistry 1988;50(4):1319-21.
1988: N J Riachi; Sami I Harik; Rajesh N. Kalaria; Lawrence M Sayre
On the mechanisms underlying 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. II. Susceptibility among mammalian species correlates with the toxin's metabolic patterns in brain microvessels and liver.
The Journal of pharmacology and experimental therapeutics 1988;244(2):443-8.
1987: A Morandi; Pierluigi Gambetti; P K Arora; Lawrence M Sayre
Mechanism of neurotoxic action of beta,beta'-iminodipropionitrile (IDPN): N-hydroxylation enhances neurotoxic potency.
Brain research 1987;437(1):69-76.
1987: Charles L Hoppel; DL Grinblatt; H C Kwok; P K Arora; M P Singh; Lawrence M Sayre; D Greenblatt
Inhibition of mitochondrial respiration by analogs of 4-phenylpyridine and 1-methyl-4-phenylpyridinium cation (MPP+), the neurotoxic metabolite of MPTP.
Biochemical and biophysical research communications 1987;148(2):684-93.
1987: D M Frank; P K Arora; J L Blumer; Lawrence M Sayre
Model study on the bioreduction of paraquat, MPP+, and analogs. Evidence against a "redox cycling" mechanism in MPTP neurotoxicity.
Biochemical and biophysical research communications 1987;147(3):1095-104.
1987: F G Njoroge; Lawrence M Sayre; Vincent M Monnier
Detection of D-glucose-derived pyrrole compounds during Maillard reaction under physiological conditions.
Carbohydrate research 1987;167():211-20.
1987: A R Jacobson; S H Coffin; C M Shearson; Lawrence M Sayre
beta,beta'-Iminodipropionitrile (IDPN) neurotoxicity: a mechanistic hypothesis for toxic activation.
Molecular toxicology 1987;1(1):17-34.
1986: Lawrence M Sayre; C M Shearson; T Wongmongkolrit; R Medori; Pierluigi Gambetti
Structural basis of gamma-diketone neurotoxicity: non-neurotoxicity of 3,3-dimethyl-2,5-hexanedione, a gamma-diketone incapable of pyrrole formation.
Toxicology and applied pharmacology 1986;84(1):36-44.