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Isobel Scarisbrick

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Kristen L Drucker; Caterina Giannini; Robert B Jenkins; Brian P O'Neill; Alex R Paulsen; Michael Blaber; Sachiko I Blaber; Paul A Decker; Joon H Uhm; Isobel A Scarisbrick
Clinical significance and novel mechanism of action of kallikrein 6 in glioblastoma.
Hyesook Yoon; Sachiko I Blaber; Wu Li; Isobel A Scarisbrick; Michael Blaber
Activation profiles of human kallikrein-related peptidases by matrix metalloproteinases.
Isobel A Scarisbrick; Hyesook Yoon; Michael Blaber; Sachiko I Blaber; Nadya Larson; Michael Panos; Moses Rodriguez
Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis.

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All Publications

2013: Kristen L Drucker; Caterina Giannini; Robert B Jenkins; Brian P O'Neill; Alex R Paulsen; Michael Blaber; Sachiko I Blaber; Paul A Decker; Joon H Uhm; Isobel A Scarisbrick
Clinical significance and novel mechanism of action of kallikrein 6 in glioblastoma.
Neuro-oncology 2013;15(3):305-18.
2013: Hyesook Yoon; Sachiko I Blaber; Wu Li; Isobel A Scarisbrick; Michael Blaber
Activation profiles of human kallikrein-related peptidases by matrix metalloproteinases.
Biological chemistry 2013;394(1):137-47.
2012: Isobel A Scarisbrick; Hyesook Yoon; Michael Blaber; Sachiko I Blaber; Nadya Larson; Michael Panos; Moses Rodriguez
Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis.
Brain pathology (Zurich, Switzerland) 2012;22(5):709-22.
2012: Isobel A Scarisbrick; Michael Blaber; Sachiko I Blaber; Joshua E Burda; Caterina Giannini; Nadya Larson; Maja Radulovic; Alexander G Vandell
Kallikrein 6 is a novel molecular trigger of reactive astrogliosis.
Biological chemistry 2012;393(5):355-67.
2011: Isobel A Scarisbrick; Benjamin Epstein; Beth A Cloud; Hyesook Yoon; Jianmin Wu; Danielle N Renner; Sachiko I Blaber; Michael Blaber; Alexander G Vandell; Alexandra L Bryson
Functional role of kallikrein 6 in regulating immune cell survival.
PloS one 2011;6(3):e18376.
2010: Michael Blaber; Hyesook Yoon; Maria A Juliano; Isobel A Scarisbrick; Sachiko I Blaber
Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis.
Biological chemistry 2010;391(4):311-20.
2009: Hyesook Yoon; Sachiko I Blaber; Mekdes Debela; Peter Goettig; Isobel A Scarisbrick; Michael Blaber
A completed KLK activome profile: investigation of activation profiles of KLK9, 10, and 15.
Biological chemistry 2009;390(4):373-7.
2008: Alexander G Vandell; Nadya Larson; Gurunathan Laxmikanthan; Michael Panos; Sachiko I Blaber; Michael Blaber; Isobel A Scarisbrick
Protease-activated receptor dependent and independent signaling by kallikreins 1 and 6 in CNS neuron and astroglial cell lines.
Journal of neurochemistry 2008;107(3):855-70.
2008: Hyesook Yoon; Sachiko I Blaber; D Michael Evans; Julie Trim; Maria Aparecida Juliano; Isobel A Scarisbrick; Michael Blaber
Activation profiles of human kallikrein-related peptidases by proteases of the thrombostasis axis.
Protein science : a publication of the Protein Society 2008;17(11):1998-2007.
2008: Isobel A Scarisbrick; Rachel Linbo; Alexander G Vandell; Mark Keegan; Sachiko I Blaber; Michael Blaber; D Sneve; Claudia F Lucchinetti; Moses Rodriguez; Eleftherios P Diamandis
Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration.
Biological chemistry 2008;389(6):739-45.
2007: Hyesook Yoon; Gurunathan Laxmikanthan; Jihun Lee; Sachiko I Blaber; Aaron Rodriguez; Joshua M Kogot; Isobel A Scarisbrick; Michael Blaber
Activation profiles and regulatory cascades of the human kallikrein-related peptidases.
The Journal of biological chemistry 2007;282(44):31852-64.
2007: Sachiko I Blaber; Hyesook Yoon; Isobel A Scarisbrick; Maria A Juliano; Michael Blaber
The autolytic regulation of human kallikrein-related peptidase 6.
Biochemistry 2007;46(17):5209-17.
2006: Katerina Oikonomopoulou; Kristina K Hansen; Mahmoud Saifeddine; Illa Tea; Michael Blaber; Sachiko I Blaber; Isobel A Scarisbrick; Patricia Andrade-Gordon; Graeme S Cottrell; Nigel W Bunnett; Eleftherios P Diamandis; Morley D Hollenberg
Proteinase-activated receptors, targets for kallikrein signaling.
The Journal of biological chemistry 2006;281(43):32095-112.
2006: Isobel A Scarisbrick; P Sabharwal; H Cruz; N Larsen; A G Vandell; Sachiko I Blaber; Syed Ameenuddin; L M Papke; M G Fehlings; R K Reeves; Michael Blaber; Anthony J Windebank; M Rodriguez
Dynamic role of kallikrein 6 in traumatic spinal cord injury.
The European journal of neuroscience 2006;24(5):1457-69.
2006: Isobel A Scarisbrick; Sachiko I Blaber; J T Tingling; Moses Rodriguez; Michael Blaber; George P Christophi
Potential scope of action of tissue kallikreins in CNS immune-mediated disease.
Journal of neuroimmunology 2006;178(1-2):167-76.
2006: Katerina Oikonomopoulou; Kristina K Hansen; Mahmoud Saifeddine; Nathalie Vergnolle; Illa Tea; Michael Blaber; Sachiko I Blaber; Isobel A Scarisbrick; Eleftherios P Diamandis; Morley D Hollenberg
Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs).
Biological chemistry 2006;387(6):817-24.
2006: Pedro Francisco Angelo; Aurelio Resende Lima; Fabiana M Alves; Sachiko I Blaber; Isobel A Scarisbrick; Michael Blaber; Luiz Juliano; Maria A Juliano
Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects.
The Journal of biological chemistry 2006;281(6):3116-26.
2005: Gurunathan Laxmikanthan; Sachiko I Blaber; Matthew J Bernett; Isobel A Scarisbrick; Maria A Juliano; Michael Blaber
1.70 A X-ray structure of human apo kallikrein 1: structural changes upon peptide inhibitor/substrate binding.
Proteins 2005;58(4):802-14.
2004: George P Christophi; PJ Isackson; Sachiko I Blaber; Michael Blaber; Moses Rodriguez; Isobel A Scarisbrick
Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease.
Journal of neurochemistry 2004;91(6):1439-49.
2004: Sachiko I Blaber; Bogoljub Ciric; George P Christophi; Matthew J Bernett; Michael Blaber; Moses Rodriguez; Isobel A Scarisbrick
Targeting kallikrein 6 proteolysis attenuates CNS inflammatory disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(7):920-2.
2002: Matthew J Bernett; Sachiko I Blaber; Isobel A Scarisbrick; Pushparani Dhanarajan; Steven M Thompson; Michael Blaber
Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system.
The Journal of biological chemistry 2002;277(27):24562-70.
2002: Isobel A Scarisbrick; Sachiko I Blaber; C F Lucchinetti; C P Genain; Michael Blaber; Moses Rodriguez
Activity of a newly identified serine protease in CNS demyelination.
Brain : a journal of neurology 2002;125(Pt 6):1283-96.
2002: Sachiko I Blaber; Isobel A Scarisbrick; Matthew J Bernett; Pushparani Dhanarajan; Margaret Seavy; Yonghao Jin; Martin A Schwartz; Moses Rodriguez; Michael Blaber
Enzymatic properties of rat myelencephalon-specific protease.
Biochemistry 2002;41(4):1165-73.
2001: Isobel A Scarisbrick; PJ Isackson; Bogoljub Ciric; Anthony J Windebank; Moses Rodriguez
MSP, a trypsin-like serine protease, is abundantly expressed in the human nervous system.
The Journal of comparative neurology 2001;431(3):347-61.
2000: Isobel A Scarisbrick; Kuni Asakura; Moses Rodriguez
Neurotrophin-4/5 promotes proliferation of oligodendrocyte-type-2 astrocytes (O-2A).
Brain research. Developmental brain research 2000;123(1):87-90.
2000: Isobel A Scarisbrick; Kuni Asakura; Sachiko I Blaber; Michael Blaber; PJ Isackson; T Bieto; Moses Rodriguez; Anthony J Windebank
Preferential expression of myelencephalon-specific protease by oligodendrocytes of the adult rat spinal cord white matter.
Glia 2000;30(3):219-30.
1999: Isobel A Scarisbrick; PJ Isackson; Anthony J Windebank
Differential expression of brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 in the adult rat spinal cord: regulation by the glutamate receptor agonist kainic acid.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(18):7757-69.
1997: Isobel A Scarisbrick; M D Towner; PJ Isackson
Nervous system-specific expression of a novel serine protease: regulation in the adult rat spinal cord by excitotoxic injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(21):8156-68.
1993: Isobel A Scarisbrick; Edward G Jones; PJ Isackson
Coexpression of mRNAs for NGF, BDNF, and NT-3 in the cardiovascular system of the pre- and postnatal rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(3):875-93.
1993: Isobel A Scarisbrick; Edward G Jones
NCAM immunoreactivity during major developmental events in the rat maxillary nerve-whisker system.
Brain research. Developmental brain research 1993;71(1):121-35.