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Roberto Scatena

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Roberto Scatena; Patrizia Bottoni; Bruno Giardina
Circulating tumour cells and cancer stem cells: a role for proteomics in defining the interrelationships between function, phenotype and differentiation with potential clinical applications.
Patrizia Bottoni; Bruno Giardina; Alessandro Pontoglio; Salvatore Scarà; Roberto Scatena
Mitochondrial proteomic approaches for new potential diagnostic and prognostic biomarkers in cancer.
Roberto Scatena
Mitochondria and drugs.

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All Publications

2013: Roberto Scatena; Patrizia Bottoni; Bruno Giardina
Circulating tumour cells and cancer stem cells: a role for proteomics in defining the interrelationships between function, phenotype and differentiation with potential clinical applications.
Biochimica et biophysica acta 2013;1835(2):129-43.
2012: Patrizia Bottoni; Bruno Giardina; Alessandro Pontoglio; Salvatore Scarà; Roberto Scatena
Mitochondrial proteomic approaches for new potential diagnostic and prognostic biomarkers in cancer.
Advances in experimental medicine and biology 2012;942():423-40.
2012: Roberto Scatena
Mitochondria and drugs.
Advances in experimental medicine and biology 2012;942():329-46.
2012: Roberto Scatena
Mitochondria and cancer: a growing role in apoptosis, cancer cell metabolism and dedifferentiation.
Advances in experimental medicine and biology 2012;942():287-308.
2011: Roberto Scatena; Patrizia Bottoni; Alessandro Pontoglio; Bruno Giardina
Cancer stem cells: the development of new cancer therapeutics.
Expert opinion on biological therapy 2011;11(7):875-92.
2010: Roberto Scatena; Patrizia Bottoni; Alessandro Pontoglio; Bruno Giardina
Revisiting the Warburg effect in cancer cells with proteomics. The emergence of new approaches to diagnosis, prognosis and therapy.
Proteomics. Clinical applications 2010;4(2):143-58.
2010: Roberto Scatena; Patrizia Bottoni; Alessandro Pontoglio; Bruno Giardina
Pharmacological modulation of nitric oxide release: new pharmacological perspectives, potential benefits and risks.
Current medicinal chemistry 2010;17(1):61-73.
2009: Patrizia Bottoni; Bruno Giardina; Roberto Scatena
Proteomic profiling of heat shock proteins: An emerging molecular approach with direct pathophysiological and clinical implications.
Proteomics. Clinical applications 2009;3(6):636-53.
2008: Roberto Scatena; Patrizia Bottoni; Alessandro Pontoglio; Lucia Mastrototaro; Bruno Giardina
Glycolytic enzyme inhibitors in cancer treatment.
Expert opinion on investigational drugs 2008;17(10):1533-45.
2008: Roberto Scatena; Patrizia Bottoni; Bruno Giardina
Mitochondria, PPARs, and Cancer: Is Receptor-Independent Action of PPAR Agonists a Key?
PPAR research 2008;2008():256251.
2007: M Cristina De Rosa; Cristiana Carelli Alinovi; Antonio Galtieri; Roberto Scatena; Bruno Giardina
The plasma membrane of erythrocytes plays a fundamental role in the transport of oxygen, carbon dioxide and nitric oxide and in the maintenance of the reduced state of the heme iron.
Gene 2007;398(1-2):162-71.
2007: Roberto Scatena; Patrizia Bottoni; Giuseppe Ettore Martorana; Federica Vincenzoni; Giorgia Botta; Paola Pastore; Bruno Giardina
Mitochondria, ciglitazone and liver: a neglected interaction in biochemical pharmacology.
European journal of pharmacology 2007;567(1-2):50-8.
2007: Roberto Scatena; Patrizia Bottoni; Giorgia Botta; Giuseppe Ettore Martorana; Bruno Giardina
The role of mitochondria in pharmacotoxicology: a reevaluation of an old, newly emerging topic.
American journal of physiology. Cell physiology 2007;293(1):C12-21.
2007: Roberto Scatena; Giuseppe Ettore Martorana; Patrizia Bottoni; Giorgia Botta; Paola Pastore; Bruno Giardina
An update on pharmacological approaches to neurodegenerative diseases.
Expert opinion on investigational drugs 2007;16(1):59-72.
2006: Antonello Mai; Silvio Massa; Sergio Valente; Silvia Simeoni; Rino Ragno; Patrizia Bottoni; Roberto Scatena; Gerald Brosch
Aroyl-pyrrolyl hydroxyamides: influence of pyrrole C4-phenylacetyl substitution on histone deacetylase inhibition.
ChemMedChem 2006;1(2):225-37.
2005: Antonello Mai; Silvio Massa; Dante Rotili; Riccardo Pezzi; Patrizia Bottoni; Roberto Scatena; Joachim Meraner; Gerald Brosch
Exploring the connection unit in the HDAC inhibitor pharmacophore model: novel uracil-based hydroxamates.
Bioorganic & medicinal chemistry letters 2005;15(21):4656-61.
2005: Roberto Scatena; Patrizia Bottoni; Giuseppe Ettore Martorana; Bruno Giardina
Nitric oxide donor drugs: an update on pathophysiology and therapeutic potential.
Expert opinion on investigational drugs 2005;14(7):835-46.
2005: Patrizia Bottoni; Bruno Giardina; Giuseppe Ettore Martorana; Cecilia Zuppi; Pasquale De Sole; Cristina Rossi; Roberto Scatena
A two-dimensional electrophoresis preliminary approach to human hepatocarcinoma differentiation induced by PPAR-agonists.
Journal of cellular and molecular medicine 2005;9(2):462-7.
2004: Roberto Scatena; Giuseppe Ettore Martorana; Patrizia Bottoni; Bruno Giardina
Mitochondrial dysfunction by synthetic ligands of peroxisome proliferator activated receptors (PPARs).
IUBMB life 2004;56(8):477-82.
2004: Roberto Scatena; Irene Messana; Giuseppe Ettore Martorana; Maria Luisa Gozzo; Silvio Lippa; Alessandro Maccaglia; Patrizia Bottoni; Federica Vincenzoni; Giuseppina Nocca; Massimo Castagnola; Bruno Giardina
Mitochondrial damage and metabolic compensatory mechanisms induced by hyperoxia in the U-937 cell line.
Journal of biochemistry and molecular biology 2004;37(4):454-9.
2004: Roberto Scatena; Patrizia Bottoni; Giuseppe Ettore Martorana; Franco Ferrari; Pasquale De Sole; Cristina Rossi; Bruno Giardina
Mitochondrial respiratory chain dysfunction, a non-receptor-mediated effect of synthetic PPAR-ligands: biochemical and pharmacological implications.
Biochemical and biophysical research communications 2004;319(3):967-73.
2004: Roberto Scatena
Nitroflurbiprofen (NicOx).
Current opinion in investigational drugs (London, England : 2000) 2004;5(5):551-6.
2004: Rino Ragno; Antonello Mai; Silvio Massa; Ilaria Cerbara; Sergio Valente; Patrizia Bottoni; Roberto Scatena; Florian Jesacher; Peter Loidl; Gerald Brosch
3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies.
Journal of medicinal chemistry 2004;47(6):1351-9.
2004: Antonello Mai; Silvio Massa; Ilaria Cerbara; Sergio Valente; Rino Ragno; Patrizia Bottoni; Roberto Scatena; Peter Loidl; Gerald Brosch
3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity.
Journal of medicinal chemistry 2004;47(5):1098-109.
2003: Roberto Scatena; Patrizia Bottoni; Federica Vincenzoni; Irene Messana; Giuseppe Ettore Martorana; Giuseppina Nocca; Pasquale De Sole; N Maggiano; Massimo Castagnola; Bruno Giardina
Bezafibrate induces a mitochondrial derangement in human cell lines: a PPAR-independent mechanism for a peroxisome proliferator.
Chemical research in toxicology 2003;16(11):1440-7.
2003: Gianluca Gambarini; M Andreasi Bassi; G Bolognini; Luca Testarelli; Giuseppina Nocca; L Ceccarelli; Roberto Scatena; Alessandro Lupi; Massimo Castagnola
Cytotoxicity of a new endodontic filling material.
Australian endodontic journal : the journal of the Australian Society of Endodontology Inc 2003;29(1):17-9.
2002: Antonello Mai; Silvio Massa; Rino Ragno; Monica Esposito; Gianluca Sbardella; Giuseppina Nocca; Roberto Scatena; Florian Jesacher; Peter Loidl; Gerald Brosch
Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation.
Journal of medicinal chemistry 2002;45(9):1778-84.
1999: Roberto Scatena; Giuseppina Nocca; P D Sole; C Rumi; Pierluigi Puggioni; F Remiddi; Patrizia Bottoni; S Ficarra; Bruno Giardina
Bezafibrate as differentiating factor of human myeloid leukemia cells.
Cell death and differentiation 1999;6(8):781-7.
1999: Giovanni Destro-Bisol; Ernesto d'Aloja; Gabriella Spedini; Roberto Scatena; Bruno Giardina; Vincenzo L Pascali
Brief communication: Resistance to Falciparum malaria in alpha-thalassemia, oxidative stress, and hemoglobin oxidation.
American journal of physical anthropology 1999;109(2):269-73.
1998: Roberto Scatena; Giuseppina Nocca; Pasquale De Sole; Patrizia Bottoni; Bruno Giardina
Impaired reactive oxygen metabolism of phagocytic leukocytes in NIDDM patients. A role for non-enzymatic glycosylation of collagen.
Journal of bioluminescence and chemiluminescence 1998;13(5):273-8.
1998: M Cristina De Rosa; Maria T Sanna; Irene Messana; Massimo Castagnola; Antonio Galtieri; Ester Tellone; Roberto Scatena; B Botta; M Botta; Bruno Giardina
Glycated human hemoglobin (HbA1c): functional characteristics and molecular modeling studies.
Biophysical chemistry 1998;72(3):323-35.
1997: Roberto Scatena; Giuseppina Nocca; Pasquale De Sole; R Fresu; Cecilia Zuppi; Bruno Giardina
The priming effect of gemfibrozil on reactive oxygen metabolism of phagocytic leucocytes. An intriguing side effect.
Clinica chimica acta; international journal of clinical chemistry 1997;266(2):173-83.
1996: Roberto Scatena; Giuseppina Nocca; Pasquale De Sole; Bruno Giardina
Monocyte oxygenation activities are significantly influenced by non-enzymatic glycosylation of collagen.
Journal of bioluminescence and chemiluminescence 1996;11(4-5):207-12.
1996: Massimo Clementi; Roberto Scatena; A Mordente; Stefano Condò; Massimo Castagnola; Bruno Giardina
Oxygen transport by fetal bovine hemoglobin.
Journal of molecular biology 1996;255(1):229-34.
1995: Roberto Scatena; Giuseppina Nocca; Irene Messana; Pasquale De Sole; S Baroni; Cecilia Zuppi; Massimo Castagnola; Bruno Giardina
Effects of gemfibrozil on the oxygen transport properties of erythrocytes.
British journal of clinical pharmacology 1995;39(1):25-30.
1995: Bruno Giardina; Irene Messana; Roberto Scatena; Massimo Castagnola
The multiple functions of hemoglobin.
Critical reviews in biochemistry and molecular biology 1995;30(3):165-96.
1994: Maria T Sanna; Bruno Giardina; Roberto Scatena; Mariagiuseppina Pellegrini; Alessandra Olianas; Laura Manca; Bruno Masala; Massimo Castagnola; Maria G Corda
Functional alterations in adult and fetal hemoglobin Sassari Asp-alpha 126(H9)-->His. The role of alpha 1 alpha 2 contact.
The Journal of biological chemistry 1994;269(28):18338-42.
1994: Massimo Coletta; S G Condo; Roberto Scatena; Massimo Clementi; S Baroni; S N Sletten; Ole Brix; Bruno Giardina
Synergistic modulation by chloride and organic phosphates of hemoglobin from bear (Ursus arctos).
Journal of molecular biology 1994;236(5):1401-6.
1993: Massimo Castagnola; Donato Di Pierro; Roberto Scatena; Barbara Tavazzi; Giuseppina Nocca; Diana Valeria Rossetti; Bruno Giardina
Separation of reduced and oxidized glutathione by micellar electrokinetic capillary chromatography.
Biomedical chromatography : BMC 1993;7(4):220-6.
1993: Bruno Giardina; Roberto Scatena; Massimo Clementi; L Cerroni; M Nuutinen; Ole Brix; S N Sletten; Massimo Castagnola; Stefano Condò
Physiological relevance of the overall delta H of oxygen binding to fetal human hemoglobin.
Journal of molecular biology 1993;229(2):512-6.
1992: Bruno Giardina; Roberto Scatena; Massimo Clementi; L Cerroni; Stefano Condò; M Nuutinen; Ole Brix
Protein engineering in haemoglobin.
Nature 1992;355(6363):777-8.
1991: Bruno Giardina; Roberto Scatena; Massimo Clementi; M T Ramacci; F Maccari; L Cerroni; Stefano Condò
Selective binding of met-hemoglobin to erythrocytic membrane: a possible involvement in red blood cell aging.
Advances in experimental medicine and biology 1991;307():75-84.
1990: Bruno Giardina; M Ekker; S G Condó; Roberto Scatena; Massimo Clementi; Ole Brix
Arctic adaptation in whale hemoglobin: interplay of carbon dioxide and temperature in the oxygen unloading.
Arctic medical research 1990;49(2):93-7.
1990: Bruno Giardina; Ole Brix; Massimo Clementi; Roberto Scatena; B Nicoletti; R Cicchetti; G Argentin; S G Condo
Differences between horse and human haemoglobins in effects of organic and inorganic anions on oxygen binding.
The Biochemical journal 1990;266(3):897-900.
1990: Ole Brix; M Ekker; S G Condó; Roberto Scatena; Massimo Clementi; Bruno Giardina
Lactate does facilitate oxygen unloading from the hemoglobin of the whale, Balaenoptera acutorostrata, after diving.
Arctic medical research 1990;49(1):39-42.
1989: Ole Brix; Stefano Condò; Giuseppe Lazzarino; Massimo Clementi; Roberto Scatena; Bruno Giardina
Arctic life adaptation--III. The function of whale (Balaenoptera acutorostrata) hemoglobin.
Comparative biochemistry and physiology. B, Comparative biochemistry 1989;94(1):139-42.