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Jochen Schacht

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Fu-Quan Chen; Jochen Schacht; Hong-Wei Zheng; Su-Hua Sha
Mitochondrial peroxiredoxin 3 regulates sensory cell survival in the cochlea.
Naoki Oishi; Andra E Talaska; Jochen Schacht
Ototoxicity in dogs and cats.
Jochen Schacht; Andra E Talaska; Leonard P Rybak
Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention.

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All Publications

2013: Fu-Quan Chen; Jochen Schacht; Hong-Wei Zheng; Su-Hua Sha
Mitochondrial peroxiredoxin 3 regulates sensory cell survival in the cochlea.
PloS one 2013;8(4):e61999.
2012: Naoki Oishi; Andra E Talaska; Jochen Schacht
Ototoxicity in dogs and cats.
The Veterinary clinics of North America. Small animal practice 2012;42(6):1259-71.
2012: Jochen Schacht; Andra E Talaska; Leonard P Rybak
Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention.
Anatomical record (Hoboken, N.J. : 2007) 2012;295(11):1837-50.
2012: Jochen Schacht; Richard A Altschuler; David T Burke; Shu Chen; David F Dolan; Andrzej T Galecki; David C Kohrman; Richard A Miller
Alleles that modulate late life hearing in genetically heterogeneous mice.
Neurobiology of aging 2012;33(8):1842.e15-29.
2012: Tanja Matt; Martin Meyer; Chyan Leong Ng; Déborah Perez-Fernandez; V Ramakrishnan; Jochen Schacht; Su-Hua Sha; Dmitry Shcherbakov; Andrea Vasella; Jing Xie; Rashid Akbergenov; Srinivas R Dubbaka; Stefan Duscha; Kathrin Lang; Erik C Böttger
Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(27):10984-9.
2012: Suhua Sha; Kimberly Anne Wearne; Kärin Halsey; Ariane C Kanicki; Jochen Schacht
Antioxidant-enriched diet does not delay the progression of age-related hearing loss.
Neurobiology of aging 2012;33(5):1010.e15-6.
2012: Fu-Quan Chen; Ya-Jun Guan; Kayla Hill; Jochen Schacht; Su-Hua Sha
Activation of apoptotic pathways in the absence of cell death in an inner-ear immortomouse cell line.
Hearing research 2012;284(1-2):33-41.
2011: Barbara Canlon; Jochen Schacht
Introduction: Pathology of the inner ear.
Hearing research 2011;281(1-2):1-2.
2011: Ken Op de Beeck; Jochen Schacht; Guy Van Camp
Apoptosis in acquired and genetic hearing impairment: the programmed death of the hair cell.
Hearing research 2011;281(1-2):18-27.
2011: Jing Xie; Andra E Talaska; Jochen Schacht
New developments in aminoglycoside therapy and ototoxicity.
Hearing research 2011;281(1-2):28-37.
2011: Naoki Oishi; Jochen Schacht
Emerging treatments for noise-induced hearing loss.
Expert opinion on emerging drugs 2011;16(2):235-45.
2011: Richard A Miller; David F Dolan; Melissa Han; William Kohler; Jochen Schacht
Resistance of skin fibroblasts to peroxide and UV damage predicts hearing loss in aging mice.
Aging cell 2011;10(2):362-3.
2010: Suhua Sha; Fu-Quan Chen; Jochen Schacht
PTEN attenuates PIP3/Akt signaling in the cochlea of the aging CBA/J mouse.
Hearing research 2010;264(1-2):86-92.
2009: Suhua Sha; Fu-Quan Chen; Jochen Schacht
Activation of cell death pathways in the inner ear of the aging CBA/J mouse.
Hearing research 2009;254(1-2):92-9.
2009: Igor Nudelman; Annie Rebibo-Sabbah; Marina Cherniavsky; Valery Belakhov; Mariana Hainrichson; Fuquan Chen; Jochen Schacht; Daniel S Pilch; Tamar Ben-Yosef; Timor Baasov
Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations.
Journal of medicinal chemistry 2009;52(9):2836-45.
2009: Fu-Quan Chen; Jochen Schacht; Suhua Sha
Aminoglycoside-induced histone deacetylation and hair cell death in the mouse cochlea.
Journal of neurochemistry 2009;108(5):1226-36.
2008: Suhua Sha; Ariane C Kanicki; Gary A Dootz; Andra E Talaska; Kärin Halsey; David F Dolan; Richard A Altschuler; Jochen Schacht
Age-related auditory pathology in the CBA/J mouse.
Hearing research 2008;243(1-2):87-94.
2008: J Samson; A Wiktorek-Smagur; P Politanski; Elzbieta Rajkowska; M Pawlaczyk-Luszczynska; A Dudarewicz; Suhua Sha; Jochen Schacht; M Sliwinska-Kowalska
Noise-induced time-dependent changes in oxidative stress in the mouse cochlea and attenuation by D-methionine.
Neuroscience 2008;152(1):146-50.
2007: Hongyan Jiang; Andra E Talaska; Jochen Schacht; Suhua Sha
Oxidative imbalance in the aging inner ear.
Neurobiology of aging 2007;28(10):1605-12.
2007: Shujiro B Minami; Daisuke Yamashita; Kaoru Ogawa; Jochen Schacht; Josef M Miller
Creatine and tempol attenuate noise-induced hearing loss.
Brain research 2007;1148():83-9.
2007: E Kharkheli; Zurab Kevanishvili; T Maglakelidze; O Davitashvili; Jochen Schacht
Does vitamin E prevent gentamicin-induced ototoxicity?
Georgian medical news 2007;(146):14-7.
2007: Yang Chen; Wei-guo Huang; Ding-Jun Zha; Jian-Hua Qiu; Jin-Ling Wang; Suhua Sha; Jochen Schacht
Aspirin attenuates gentamicin ototoxicity: from the laboratory to the clinic.
Hearing research 2007;226(1-2):178-82.
2007: N Sharashenidze; Jochen Schacht; Zurab Kevanishvili
Age-related hearing loss: gender differences.
Georgian medical news 2007;(144):14-8.
2006: Hongyan Jiang; Suhua Sha; Jochen Schacht
Kanamycin alters cytoplasmic and nuclear phosphoinositide signaling in the organ of Corti in vivo.
Journal of neurochemistry 2006;99(1):269-76.
2006: Hongyan Jiang; Suhua Sha; Jochen Schacht
Rac/Rho pathway regulates actin depolymerization induced by aminoglycoside antibiotics.
Journal of neuroscience research 2006;83(8):1544-51.
2006: M Angeles Vicente-Torres; Jochen Schacht
A BAD link to mitochondrial cell death in the cochlea of mice with noise-induced hearing loss.
Journal of neuroscience research 2006;83(8):1564-72.
2006: Suhua Sha; Jian-Hua Qiu; Jochen Schacht
Aspirin to prevent gentamicin-induced hearing loss.
The New England journal of medicine 2006;354(17):1856-7.
2006: Wei-jia Kong; Jin Hao; Jochen Schacht
Sketches of otohistory Part 12: The history of otology in traditional Chinese medicine.
Audiology & neuro-otology 2006;11(3):145-50.
2006: Jochen Schacht; Joseph E Hawkins
Sketches of otohistory. Part 11: Ototoxicity: drug-induced hearing loss.
Audiology & neuro-otology 2006;11(1):1-6.
2006: Hongyan Jiang; Suhua Sha; Andrew Forge; Jochen Schacht
Caspase-independent pathways of hair cell death induced by kanamycin in vivo.
Cell death and differentiation 2006;13(1):20-30.
2005: Joseph E Hawkins; Jochen Schacht
Sketches of otohistory. Part 10: noise-induced hearing loss.
Audiology & neuro-otology 2005;10(6):305-9.
2005: Jochen Schacht; Joseph E Hawkins
Sketches of otohistory. Part 9: presby[a]cusis.
Audiology & neuro-otology 2005;10(5):243-7.
2005: Joseph E Hawkins; Jochen Schacht
Sketches of otohistory. Part 8: The emergence of vestibular science.
Audiology & neuro-otology 2005;10(4):185-90.
2005: Joseph E Hawkins; Jochen Schacht
Sketches of otohistory. Part 7: The nineteenth-century rise of laryngology.
Audiology & neuro-otology 2005;10(3):130-3.
2005: Hongyan Jiang; Suhua Sha; Jochen Schacht
NF-kappaB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity.
Journal of neuroscience research 2005;79(5):644-51.
2005: Tsuyoshi Endo; Takayuki Nakagawa; Fukuichiro Iguchi; Tomoko Kita; Takayuki Okano; Suhua Sha; Jochen Schacht; Atsushi Shiga; Tae-Soo Kim; Juichi Ito
Elevation of superoxide dismutase increases acoustic trauma from noise exposure.
Free radical biology & medicine 2005;38(4):492-8.
2005: Wojciech Lesniak; vincent pecoraro; Jochen Schacht
Ternary complexes of gentamicin with iron and lipid catalyze formation of reactive oxygen species.
Chemical research in toxicology 2005;18(2):357-64.
2005: Daisuke Yamashita; Hong-Yan Jiang; Colleen Le Prell; Jochen Schacht; Josef M Miller
Post-exposure treatment attenuates noise-induced hearing loss.
Neuroscience 2005;134(2):633-42.
2004: Daisuke Yamashita; Josef M Miller; Hong-Yan Jiang; Shujiro B Minami; Jochen Schacht
AIF and EndoG in noise-induced hearing loss.
Neuroreport 2004;15(18):2719-22.
2004: Shujiro B Minami; Suhua Sha; Jochen Schacht
Antioxidant protection in a new animal model of cisplatin-induced ototoxicity.
Hearing research 2004;198(1-2):137-43.
2004: Jochen Schacht; Joseph E Hawkins
Sketches of otohistory part 4: a cell by any other name: cochlear eponyms.
Audiology & neuro-otology 2004;9(6):317-27.
2004: Shujiro B Minami; Daisuke Yamashita; Jochen Schacht; Josef M Miller
Calcineurin activation contributes to noise-induced hearing loss.
Journal of neuroscience research 2004;78(3):383-92.
2004: Daisuke Yamashita; Hong-Yan Jiang; Jochen Schacht; Josef M Miller
Delayed production of free radicals following noise exposure.
Brain research 2004;1019(1-2):201-9.
2004: Jürgen Lautermann; Nathalie Dehne; Jochen Schacht; K Jahnke
[Aminoglycoside- and cisplatin-ototoxicity: from basic science to clinics].
Laryngo- rhino- otologie 2004;83(5):317-23.
2004: Kohei Kawamoto; Suhua Sha; Ryosei Minoda; Masahiko Izumikawa; Hiromichi Kuriyama; Jochen Schacht; Yehoash Raphael
Antioxidant gene therapy can protect hearing and hair cells from ototoxicity.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(2):173-81.
2004: T Matsunobu; Kiyokazu Ogita; Jochen Schacht
Modulation of activator protein 1/DNA binding activity by acoustic overstimulation in the guinea-pig cochlea.
Neuroscience 2004;123(4):1037-43.
2003: Wojciech Lesniak; John Mc Laren; Wesley R Harris; vincent pecoraro; Jochen Schacht
An isocratic separation of underivatized gentamicin components, 1H NMR assignment and protonation pattern.
Carbohydrate research 2003;338(24):2853-62.
2003: Colleen Le Prell; David F Dolan; Jochen Schacht; Josef M Miller; Margaret I Lomax; Richard A Altschuler
Pathways for protection from noise induced hearing loss.
Noise & health 2003;5(20):1-17.
2003: Josef M Miller; J Nadine Brown; Jochen Schacht
8-iso-prostaglandin F(2alpha), a product of noise exposure, reduces inner ear blood flow.
Audiology & neuro-otology 2003;8(4):207-21.
2003: Ai-Mei Wang; Suhua Sha; Wojciech Lesniak; Jochen Schacht
Tanshinone (Salviae miltiorrhizae extract) preparations attenuate aminoglycoside-induced free radical formation in vitro and ototoxicity in vivo.
Antimicrobial agents and chemotherapy 2003;47(6):1836-41.
2003: Jürgen Lautermann; Jochen Schacht; K Jahnke
[Aminoglycoside toxicity. Pathomechanisms, clinical management and means of prevention].
HNO 2003;51(4):344-51; quiz 352.
2003: Yoshimitsu Ohinata; Josef M Miller; Jochen Schacht
Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea.
Brain research 2003;966(2):265-73.
2003: Wojciech Lesniak; Wesley R Harris; Joslyn Yudenfreund Kravitz; Jochen Schacht; vincent pecoraro
Solution chemistry of copper(II)-gentamicin complexes: relevance to metal-related aminoglycoside toxicity.
Inorganic chemistry 2003;42(5):1420-9.
2002: Wei-Jing Wu; Suhua Sha; Jochen Schacht
Recent advances in understanding aminoglycoside ototoxicity and its prevention.
Audiology & neuro-otology 2002;7(3):171-4.
2002: Geming Li; Suhua Sha; Elena Zotova; Joseph C Arezzo; Thomas R Van De Water; Jochen Schacht
Salicylate protects hearing and kidney function from cisplatin toxicity without compromising its oncolytic action.
Laboratory investigation; a journal of technical methods and pathology 2002;82(5):585-96.
2001: J W Chung; Jochen Schacht
ATP and nitric oxide modulate intracellular calcium in isolated pillar cells of the guinea pig cochlea.
Journal of the Association for Research in Otolaryngology : JARO 2001;2(4):399-407.
2001: Wei-Jing Wu; Suhua Sha; JD McLaren; Kohei Kawamoto; Yehoash Raphael; Jochen Schacht
Aminoglycoside ototoxicity in adult CBA, C57BL and BALB mice and the Sprague-Dawley rat.
Hearing research 2001;158(1-2):165-78.
2001: Suhua Sha; G Zajic; C J Epstein; Jochen Schacht
Overexpression of copper/zinc-superoxide dismutase protects from kanamycin-induced hearing loss.
Audiology & neuro-otology 2001;6(3):117-23.
2001: Suhua Sha; R Taylor; Andrew Forge; Jochen Schacht
Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals.
Hearing research 2001;155(1-2):1-8.
2001: T Matsunobu; J W Chung; Jochen Schacht
Acetylcholine-evoked calcium increases in Deiters' cells of the guinea pig cochlea suggest alpha9-like receptors.
Journal of neuroscience research 2001;63(3):252-6.
2000: P Sinswat; Wei-Jing Wu; Suhua Sha; Jochen Schacht
Protection from ototoxicity of intraperitoneal gentamicin in guinea pig.
Kidney international 2000;58(6):2525-32.
2000: Yoshimitsu Ohinata; Josef M Miller; Richard A Altschuler; Jochen Schacht
Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea.
Brain research 2000;878(1-2):163-73.
2000: Yoshimitsu Ohinata; Tatsuya Yamasoba; Jochen Schacht; Josef M Miller
Glutathione limits noise-induced hearing loss.
Hearing research 2000;146(1-2):28-34.
2000: T Matsunobu; Jochen Schacht
Nitric oxide/cyclic GMP pathway attenuates ATP-evoked intracellular calcium increase in supporting cells of the guinea pig cochlea.
The Journal of comparative neurology 2000;423(3):452-61.
2000: M R Gilmartin; JD McLaren; Jochen Schacht
Confounding factors in lanthanide ion probe spectrofluorometric assay of aminoglycoside antibiotics.
Analytical biochemistry 2000;283(1):116-9.
2000: Suhua Sha; Jochen Schacht
Antioxidants attenuate gentamicin-induced free radical formation in vitro and ototoxicity in vivo: D-methionine is a potential protectant.
Hearing research 2000;142(1-2):34-40.
2000: Kiyokazu Ogita; T Matsunobu; Jochen Schacht
Acoustic trauma enhances DNA binding of transcription factor AP-1 in the guinea pig inner ear.
Neuroreport 2000;11(4):859-62.
2000: Andrew Forge; Jochen Schacht
Aminoglycoside antibiotics.
Audiology & neuro-otology 2000;5(1):3-22.
1999: Jochen Schacht
Antioxidant therapy attenuates aminoglycoside-induced hearing loss.
Annals of the New York Academy of Sciences 1999;884():125-30.
1999: Suhua Sha; Jochen Schacht
Salicylate attenuates gentamicin-induced ototoxicity.
Laboratory investigation; a journal of technical methods and pathology 1999;79(7):807-13.
1999: F Tian; JD Fessenden; Jochen Schacht
Cyclic GMP-dependent protein kinase-I in the guinea pig cochlea.
Hearing research 1999;131(1-2):63-70.
1999: Suhua Sha; Jochen Schacht
Stimulation of free radical formation by aminoglycoside antibiotics.
Hearing research 1999;128(1-2):112-8.
1999: Suhua Sha; Jochen Schacht
Formation of reactive oxygen species following bioactivation of gentamicin.
Free radical biology & medicine 1999;26(3-4):341-7.
1999: JD Fessenden; Richard A Altschuler; Audrey F Seasholtz; Jochen Schacht
Nitric oxide/cyclic guanosine monophosphate pathway in the peripheral and central auditory system of the rat.
The Journal of comparative neurology 1999;404(1):52-63.
1999: Tatsuya Yamasoba; Jochen Schacht; F Shoji; Josef M Miller
Attenuation of cochlear damage from noise trauma by an iron chelator, a free radical scavenger and glial cell line-derived neurotrophic factor in vivo.
Brain research 1999;815(2):317-25.
1999: Jochen Schacht
Biochemistry and pharmacology of aminoglycoside-induced hearing loss.
Acta physiologica, pharmacologica et therapeutica latinoamericana : órgano de la Asociación Latinoamericana de Ciencias Fisiológicas y [de] la Asociación Latinoamericana de Farmacología 1999;49(4):251-6.
1999: Kaoru Ogawa; Jochen Schacht
Aging does not alter phosphoinositide hydrolysis in the rat cochlear lateral wall.
Auris, nasus, larynx 1999;26(1):1-4.
1998: Suhua Sha; Jochen Schacht
Are aminoglycoside antibiotics excitotoxic?
Neuroreport 1998;9(17):3893-5.
1998: B B Song; Suhua Sha; Jochen Schacht
Iron chelators protect from aminoglycoside-induced cochleo- and vestibulo-toxicity.
Free radical biology & medicine 1998;25(2):189-95.
1998: Jochen Schacht
Creating partnerships with clinic associations to preserve the safety net.
Health affairs (Project Hope) 1998;17(3):248-52.
1998: Jochen Schacht
Aminoglycoside ototoxicity: prevention in sight?
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 1998;118(5):674-7.
1998: JD Fessenden; Jochen Schacht
The nitric oxide/cyclic GMP pathway: a potential major regulator of cochlear physiology.
Hearing research 1998;118(1-2):168-76.
1997: B Puschner; Jochen Schacht
Energy metabolism in cochlear outer hair cells in vitro.
Hearing research 1997;114(1-2):102-6.
1997: Jürgen Lautermann; S A Crann; JD McLaren; Jochen Schacht
Glutathione-dependent antioxidant systems in the mammalian inner ear: effects of aging, ototoxic drugs and noise.
Hearing research 1997;114(1-2):75-82.
1997: Brenda M Ryals; edwina westbrook; Jochen Schacht
Morphological evidence of ototoxicity of the iron chelator deferoxamine.
Hearing research 1997;112(1-2):44-8.
1997: JD Fessenden; Jochen Schacht
Localization of soluble guanylate cyclase activity in the guinea pig cochlea suggests involvement in regulation of blood flow and supporting cell physiology.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1997;45(10):1401-8.
1997: Suhua Sha; Jochen Schacht
Prevention of aminoglycoside-induced hearing loss.
The Keio journal of medicine 1997;46(3):115-9.
1997: B Puschner; Jochen Schacht
Calmodulin-dependent protein kinases mediate calcium-induced slow motility of mammalian outer hair cells.
Hearing research 1997;110(1-2):251-8.
1997: B B Song; D J Anderson; Jochen Schacht
Protection from gentamicin ototoxicity by iron chelators in guinea pig in vivo.
The Journal of pharmacology and experimental therapeutics 1997;282(1):369-77.
1997: Joseph E Hawkins; Jochen Schacht
Smith et al.:"The electrolytes of the labyrinthine fluids." (Laryngoscope 1954;64:141-153).
The Laryngoscope 1997;107(3):293-7.
1997: E M Priuska; Jochen Schacht
Mechanism and prevention of aminoglycoside ototoxicity: outer hair cells as targets and tools.
Ear, nose, & throat journal 1997;76(3):164-6, 168, 170-1.
1996: J Lautermann; Jochen Schacht
A sensitive animal model to assess acute and chronic ototoxic effects.
Archives of otolaryngology--head & neck surgery 1996;122(8):837-40.
1996: B B Song; Jochen Schacht
Variable efficacy of radical scavengers and iron chelators to attenuate gentamicin ototoxicity in guinea pig in vivo.
Hearing research 1996;94(1-2):87-93.
1996: S A Crann; Jochen Schacht
Activation of aminoglycoside antibiotics to cytotoxins.
Audiology & neuro-otology 1996;1(2):80-5.
1995: J Lautermann; Jochen Schacht
[Reduced nutritional status enhances ototoxicity].
Laryngo- rhino- otologie 1995;74(12):724-7.
1995: E M Priuska; Jochen Schacht
Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex.
Biochemical pharmacology 1995;50(11):1749-52.
1995: Jose Antonio Lopez-Escamez; Jochen Schacht
Mechanically induced calcium increases in isolated vestibular hair cells of the guinea pig.
Acta oto-laryngologica 1995;115(6):759-64.
1995: J Lautermann; B Song; J McLaren; Jochen Schacht
Diet is a risk factor in cisplatin ototoxicity.
Hearing research 1995;88(1-2):47-53.
1995: K Ogawa; Jochen Schacht
P2y purinergic receptors coupled to phosphoinositide hydrolysis in tissues of the cochlear lateral wall.
Neuroreport 1995;6(11):1538-40.
1995: J Lautermann; J McLaren; Jochen Schacht
Glutathione protection against gentamicin ototoxicity depends on nutritional status.
Hearing research 1995;86(1-2):15-24.
1995: D E Coling; Jochen Schacht
Second messengers in the cochlea.
Acta oto-laryngologica 1995;115(2):218-21.
1994: J D Fessenden; D E Coling; Jochen Schacht
Detection and characterization of nitric oxide synthase in the mammalian cochlea.
Brain research 1994;668(1-2):9-15.
1994: K Lamm; G Zajic; Jochen Schacht
Living isolated cells from inner ear vessels: a new approach for studying the regulation of cochlear microcirculation and vascular permeability.
Hearing research 1994;81(1-2):83-90.
1994: Susan L Garetz; Richard A Altschuler; Jochen Schacht
Attenuation of gentamicin ototoxicity by glutathione in the guinea pig in vivo.
Hearing research 1994;77(1-2):81-7.
1994: Susan L Garetz; D J Rhee; Jochen Schacht
Sulfhydryl compounds and antioxidants inhibit cytotoxicity to outer hair cells of a gentamicin metabolite in vitro.
Hearing research 1994;77(1-2):75-80.
1994: K Ogawa; Jochen Schacht
G-proteins coupled to phosphoinositide hydrolysis in the cochlear and vestibular sensory epithelia of the rat are insensitive to cholera and pertussis toxins.
Hearing research 1994;74(1-2):197-203.
1994: K Ogawa; J McLaren; Jochen Schacht
Effect of aging on myo-inositol and phosphoinositide metabolism in the cochlear and vestibular sensory epithelia of the rat.
Hearing research 1994;73(2):155-62.
1994: D E Coling; R M Naik; Jochen Schacht
Calcium and calmodulin inhibit phosphorylation of a novel auditory nerve protein.
Hearing research 1994;72(1-2):197-205.
1993: A el Barbary; Richard A Altschuler; Jochen Schacht
Glutathione S-transferases in the organ of Corti of the rat: enzymatic activity, subunit composition and immunohistochemical localization.
Hearing research 1993;71(1-2):80-90.
1993: D R Schwartz; Jochen Schacht; Josef M Miller; Kirk A Frey; Richard A Altschuler
Chronic electrical stimulation reverses deafness-related depression of electrically evoked 2-deoxyglucose activity in the guinea pig inferior colliculus.
Hearing research 1993;70(2):243-9.
1993: Jochen Schacht
Biochemical basis of aminoglycoside ototoxicity.
Otolaryngologic clinics of North America 1993;26(5):845-56.
1993: K Ogawa; Jochen Schacht
Receptor-mediated release of inositol phosphates in the cochlear and vestibular sensory epithelia of the rat.
Hearing research 1993;69(1-2):207-14.
1993: G Zajic; Andrew Forge; Jochen Schacht
Membrane stains as an objective means to distinguish isolated inner and outer hair cells.
Hearing research 1993;66(1):53-7.
1993: Andrew Forge; G Zajic; L Li; G Nevill; Jochen Schacht
Structural variability of the sub-surface cisternae in intact, isolated outer hair cells shown by fluorescent labelling of intracellular membranes and freeze-fracture.
Hearing research 1993;64(2):175-83.
1992: A S Niedzielski; T Ono; Jochen Schacht
Cholinergic regulation of the phosphoinositide second messenger system in the guinea pig organ of Corti.
Hearing research 1992;59(2):250-4.
1992: S A Crann; M Y Huang; J D McLaren; Jochen Schacht
Formation of a toxic metabolite from gentamicin by a hepatic cytosolic fraction.
Biochemical pharmacology 1992;43(8):1835-9.
1992: Didier Dulon; Jochen Schacht
Motility of cochlear outer hair cells.
The American journal of otology 1992;13(2):108-12.
1992: A S Niedzielski; Jochen Schacht
P2 purinoceptors stimulate inositol phosphate release in the organ of Corti.
Neuroreport 1992;3(3):273-5.
1991: M Ptok; Thankam S Nair; Richard A Altschuler; Jochen Schacht; Thomas Carey
Monoclonal antibodies to inner ear antigens: II. Antigens expressed in sensory cell stereocilia.
Hearing research 1991;57(1):79-90.
1991: R Pujol; G Zajic; Didier Dulon; Yehoash Raphael; Richard A Altschuler; Jochen Schacht
First appearance and development of motile properties in outer hair cells isolated from guinea-pig cochlea.
Hearing research 1991;57(1):129-41.
1991: D E Coling; Jochen Schacht
Protein phosphorylation in the organ of Corti: differential regulation by second messengers between base and apex.
Hearing research 1991;57(1):113-20.
1991: A S Niedzielski; Jochen Schacht
Phospholipid metabolism in the cochlea: differences between base and apex.
Hearing research 1991;57(1):107-12.
1991: S A Crann; Thomas R Van De Water; Jochen Schacht
Ornithine decarboxylase activity during development of the mouse inner ear in vivo and in vitro.
Cell and tissue research 1991;265(3):547-50.
1991: G Zajic; Jochen Schacht
Shape changes in isolated outer hair cells: measurements with attached microspheres.
Hearing research 1991;52(2):407-10.
1991: G Zajic; Thankam S Nair; M Ptok; Carter Van Waes; Richard A Altschuler; Jochen Schacht; Thomas Carey
Monoclonal antibodies to inner ear antigens: I. Antigens expressed by supporting cells of the guinea pig cochlea.
Hearing research 1991;52(1):59-71.
1991: Didier Dulon; G Zajic; Jochen Schacht
Differential motile response of isolated inner and outer hair cells to stimulation by potassium and calcium ions.
Hearing research 1991;52(1):225-31.
1990: M Y Huang; Jochen Schacht
Formation of a cytotoxic metabolite from gentamicin by liver.
Biochemical pharmacology 1990;40(11):R11-4.
1990: S Wang; Jochen Schacht
Insulin stimulates protein synthesis and phospholipid signaling systems but does not regulate glucose uptake in the inner ear.
Hearing research 1990;47(1-2):53-61.
1990: Richard P Bobbin; M Fallon; Jean-Luc Puel; G Bryant; Sanford C Bledsoe; G Zajic; Jochen Schacht
Acetylcholine, carbachol, and GABA induce no detectable change in the length of isolated outer hair cells.
Hearing research 1990;47(1-2):39-52.
1990: M Huang; D Dulon; Jochen Schacht
Outer hair cells as potential targets of inflammatory mediators.
The Annals of otology, rhinology & laryngology. Supplement 1990;148():35-8.
1990: Didier Dulon; G Zajic; Jochen Schacht
Increasing intracellular free calcium induces circumferential contractions in isolated cochlear outer hair cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(4):1388-97.
1989: M Y Huang; Jochen Schacht
Drug-induced ototoxicity. Pathogenesis and prevention.
Medical toxicology and adverse drug experience 1989;4(6):452-67.
1989: Didier Dulon; G Zajic; J M Aran; Jochen Schacht
Aminoglycoside antibiotics impair calcium entry but not viability and motility in isolated cochlear outer hair cells.
Journal of neuroscience research 1989;24(2):338-46.
1989: Didier Dulon; G Zajic; Jochen Schacht
Photo-induced irreversible shortening and swelling of isolated cochlear outer hair cells.
International journal of radiation biology 1989;55(6):1007-14.
1989: M Riaz; ND Weiner; Jochen Schacht
Separation of liposome populations differing in phosphoinositide content by chromatography on immobilized neomycin.
Journal of pharmaceutical sciences 1989;78(2):172-5.
1989: T Ono; Jochen Schacht
Acoustic stimulation increases phosphoinositide breakdown in the guinea pig cochlea.
Neurochemistry international 1989;14(3):327-30.
1989: Andrew Forge; G Zajic; S Davies; N Weiner; Jochen Schacht
Gentamicin alters membrane structure as shown by freeze-fracture of liposomes.
Hearing research 1989;37(2):129-39.
1988: L Carlisle; G Zajic; Richard A Altschuler; Jochen Schacht; P R Thorne
Species differences in the distribution of infracuticular F-actin in outer hair cells of the cochlea.
Hearing research 1988;33(2):201-5.
1988: C M Henley; L G Mahran; Jochen Schacht
Inhibition of renal ornithine decarboxylase by aminoglycoside antibiotics in vitro.
Biochemical pharmacology 1988;37(9):1679-82.
1988: Didier Dulon; Jean-Marie Aran; Jochen Schacht
Potassium-depolarization induces motility in isolated outer hair cells by an osmotic mechanism.
Hearing research 1988;32(2-3):123-9.
1988: C M Henley; Jochen Schacht
Pharmacokinetics of aminoglycoside antibiotics in blood, inner-ear fluids and tissues and their relationship to ototoxicity.
Audiology : official organ of the International Society of Audiology 1988;27(3):137-46.
1987: C M Henley; H J Gerhardt; Jochen Schacht
Inhibition of inner ear ornithine decarboxylase by neomycin in-vitro.
Brain research bulletin 1987;19(6):695-8.
1987: Jochen Schacht; H P Zenner
Evidence that phosphoinositides mediate motility in cochlear outer hair cells.
Hearing research 1987;31(2):155-9.
1987: S Au; N D Weiner; Jochen Schacht
Aminoglycoside antibiotics preferentially increase permeability in phosphoinositide-containing membranes: a study with carboxyfluorescein in liposomes.
Biochimica et biophysica acta 1987;902(1):80-6.
1987: S E Williams; D E Smith; Jochen Schacht
Characteristics of gentamicin uptake in the isolated crista ampullaris of the inner ear of the guinea pig.
Biochemical pharmacology 1987;36(1):89-95.
1987: P R Thorne; L Carlisle; G Zajic; Jochen Schacht; Richard A Altschuler
Differences in the distribution of F-actin in outer hair cells along the organ of Corti.
Hearing research 1987;30(2-3):253-65.
1987: S E Williams; H P Zenner; Jochen Schacht
Three molecular steps of aminoglycoside ototoxicity demonstrated in outer hair cells.
Hearing research 1987;30(1):11-8.
1987: Didier Dulon; Jean-Marie Aran; Jochen Schacht
Osmotically induced motility of outer hair cells: implications for Menière's disease.
Archives of oto-rhino-laryngology 1987;244(2):104-7.
1987: G Zajic; Jochen Schacht
Comparison of isolated outer hair cells from five mammalian species.
Hearing research 1987;26(3):249-56.
1986: S Au; Jochen Schacht; N Weiner
Membrane effects of aminoglycoside antibiotics measured in liposomes containing the fluorescent probe, 1-anilino-8-naphthalene sulfonate.
Biochimica et biophysica acta 1986;862(1):205-10.
1986: H P Zenner; Jochen Schacht
[Hearing loss caused by aminoglycoside antibiotics: affect on the membrane component PIP2 in outer hair cells as the mechanism of action].
HNO 1986;34(10):417-23.
1986: S Au; N Weiner; Jochen Schacht
Membrane perturbation by aminoglycosides as a simple screen of their toxicity.
Antimicrobial agents and chemotherapy 1986;30(3):395-7.
1986: Jochen Schacht; Thomas R Van De Water
Uptake and accumulation of gentamicin in the developing inner ear of the mouse in vitro.
Biochemical pharmacology 1986;35(16):2843-5.
1986: Didier Dulon; J M Aran; G Zajic; Jochen Schacht
Comparative uptake of gentamicin, netilmicin, and amikacin in the guinea pig cochlea and vestibule.
Antimicrobial agents and chemotherapy 1986;30(1):96-100.
1986: P Tran Ba Huy; P Bernard; Jochen Schacht
Kinetics of gentamicin uptake and release in the rat. Comparison of inner ear tissues and fluids with other organs.
The Journal of clinical investigation 1986;77(5):1492-500.
1986: S E Williams; Jochen Schacht
Binding of neomycin and calcium to phospholipids and other anionic compounds.
The Journal of antibiotics 1986;39(3):457-62.
1986: Jochen Schacht
Molecular mechanisms of drug-induced hearing loss.
Hearing research 1986;22():297-304.
1986: Jochen Schacht; N Weiner
Aminoglycoside-induced hearing loss: a molecular hypothesis.
ORL; journal for oto-rhino-laryngology and its related specialties 1986;48(2):116-23.
1985: A Takada; Sanford C Bledsoe; Jochen Schacht
An energy-dependent step in aminoglycoside ototoxicity: prevention of gentamicin ototoxicity during reduced endolymphatic potential.
Hearing research 1985;19(3):245-51.
1985: Jochen Schacht
Hormonal regulation of adenylate cyclase in the stria vascularis of the mouse.
Hearing research 1985;20(1):9-13.
1984: B M Wang; ND Weiner; M G Ganesan; Jochen Schacht
Interaction of calcium and neomycin with anionic phospholipid-lecithin liposomes. A differential scanning calorimetry study.
Biochemical pharmacology 1984;33(23):3787-91.
1984: B M Wang; ND Weiner; A Takada; Jochen Schacht
Characterization of aminoglycoside-lipid interactions and development of a refined model for ototoxicity testing.
Biochemical pharmacology 1984;33(20):3257-62.
1984: M Anniko; Jochen Schacht
Inductive tissue interactions during inner ear development.
Archives of oto-rhino-laryngology 1984;240(1):17-33.
1984: G Zajic; M D Graham; Jochen Schacht
Gamma-carboxyglutamate in normal and pathological human middle ear bones.
Archives of oto-rhino-laryngology 1984;241(1):51-4.
1984: B Canlon; A Takada; Jochen Schacht
Glucose utilization in the auditory system: cochlear dysfunctions and species differences.
Comparative biochemistry and physiology. A, Comparative physiology 1984;78(1):43-7.
1983: M G Ganesan; ND Weiner; Jochen Schacht
Effects of calcium and neomycin on phase behavior of phospholipid bilayers.
Journal of pharmaceutical sciences 1983;72(12):1465-7.
1983: A Takada; B Canlon; Jochen Schacht
Gentamicin ototoxicity dissociated from glucose uptake and utilization.
Research communications in chemical pathology and pharmacology 1983;42(2):203-12.
1983: M Tachibana; M Anniko; Jochen Schacht
Effects of perilymphatically perfused gentamicin on microphonic potential, lipid labeling and morphology of cochlear tissues.
Acta oto-laryngologica 1983;96(1-2):31-8.
1983: G Zajic; M Anniko; Jochen Schacht
Cellular localization of adenylate cyclase in the developing and mature inner ear of the mouse.
Hearing research 1983;10(3):249-61.
1983: B Canlon; Jochen Schacht
Acoustic stimulation alters deoxyglucose uptake in the mouse cochlea and inferior colliculus.
Hearing research 1983;10(2):217-26.
1983: G Zajic; Jochen Schacht
Cytochemical demonstration of adenylate cyclase with strontium chloride in the rat pancreas.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1983;31(1):25-8.
1982: A Takada; S Lodhi; N D Weiner; Jochen Schacht
Lysine and polylysine: correlation of their effects on polyphosphoinositides in vitro with ototoxic action in vivo.
Journal of pharmaceutical sciences 1982;71(12):1410-1.
1982: M Anniko; A Takada; Jochen Schacht
Comparative ototoxicities of gentamicin and netilmicin in three model systems.
American journal of otolaryngology 1982;3(6):422-33.
1982: A Takada; Jochen Schacht
Calcium antagonism and reversibility of gentamicin-induced loss of cochlear microphonics in the guinea pig.
Hearing research 1982;8(2):179-86.
1982: M Anniko; D Bagger-Sjöbäck; J Wersäll; Jochen Schacht
Gentamicin binding to the isolated crista ampullaris of the guinea pig.
Research communications in chemical pathology and pharmacology 1982;37(3):333-42.
1982: Jochen Schacht
Adenylate cyclase and cochlear fluid balance.
American journal of otolaryngology 1982;3(5):328-31.
1982: C S Desrochers; Jochen Schacht
Neomycin concentrations in inner ear tissues and other organs of the guinea pig after chronic drug administration.
Acta oto-laryngologica 1982;93(3-4):233-6.
1982: A Orsulakova; Jochen Schacht
A biochemical mechanism of the ototoxic interaction between neomycin and ethacrynic acid.
Acta oto-laryngologica 1982;93(1-2):43-8.
1981: C S Desrochers; Jochen Schacht
Assay of aminoglycosides is influenced by tissue homogenization technique.
Experientia 1981;37(12):1357-8.
1981: M Anniko; M L Spångberg; Jochen Schacht
Adenylate cyclase activity in the fetal and the early postnatal inner ear of the mouse.
Hearing research 1981;4(1):11-22.
1981: B Canlon; Jochen Schacht
The effect of noise on deoxyglucose uptake into inner ear tissues of the mouse.
Archives of oto-rhino-laryngology 1981;230(2):171-6.
1981: M Tachibana; W Jung; K Schindler; Jochen Schacht
Are aminosugars ototoxic?
Archives of oto-rhino-laryngology 1981;230(2):103-7.
1981: M Anniko; H Nordemar; M L Spångberg; Jochen Schacht
Biochemical studies on the embryonic development of the mammalian inner ear in organ culture.
Archives of oto-rhino-laryngology 1981;230(3):237-43.
1981: S C Marks; Jochen Schacht
Effects of ototoxic diuretics on cochlear Na+/K+-ATPase and adenylate cyclase.
Scandinavian audiology. Supplementum 1981;14 Suppl():131-8.
1981: Jochen Schacht
Extraction and purification of polyphosphoinositides.
Methods in enzymology 1981;72():626-31.
1981: M Anniko; Jochen Schacht
Phosphoinositides in the developing inner ear with references to brain, kidney and liver of the mouse.
The International journal of biochemistry 1981;13(8):951-3.
1980: P L Kilian; Jochen Schacht
Sound stimulates labeling of polyphosphoinositides in the auditory organ of the noctuid moth.
Journal of neurochemistry 1980;34(3):709-12.
1980: S Lodhi; N D Weiner; I Mechigian; Jochen Schacht
Ototoxicity of aminoglycosides correlated with their action on monomolecular films of polyphosphoinositides.
Biochemical pharmacology 1980;29(4):597-601.
1980: D Bagger-Sjöbäck; C S Filipek; Jochen Schacht
Characteristics and drug responses of cochlear and vestibular adenylate cyclase.
Archives of oto-rhino-laryngology 1980;228(3):217-22.
1979: S Lodhi; N D Weiner; Jochen Schacht
Interactions of neomycin with monomolecular films of polyphosphoinositides and other lipids.
Biochimica et biophysica acta 1979;557(1):1-8.
1979: I Mechigian; R E Preston; L G Johnsson; Jochen Schacht
Incorporation of radioactive calcium into otolithic membranes of the guinea pig after aminoglycoside treatment.
Acta oto-laryngologica 1979;88(1-2):56-60.
1979: Jochen Schacht
Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney.
Archives of oto-rhino-laryngology 1979;224(1-2):129-34.
1979: P L Kilian; Jochen Schacht
Polyphosphoinositides in insect muscle and sensory tissues.
Journal of neurochemistry 1979;32(1):247-8.
1978: Jochen Schacht
Purification of polyphosphoinositides by chromatography on immobilized neomycin.
Journal of lipid research 1978;19(8):1063-7.
1977: A Schibeci; Jochen Schacht
Action of neomycin on the metabolism of polyphosphoinositides in the guinea pig kidney.
Biochemical pharmacology 1977;26(19):1769-74.
1977: E Stockhorst; Jochen Schacht
Radioactive labeling of phospholipids and proteins by cochlear perfusion in the guinea pig and the effect of neomycin.
Acta oto-laryngologica 1977;83(5-6):401-9.
1977: Jochen Schacht; S Lodhi; N D Weiner
Effects of neomycin on polyphosphoinositides in inner ear tissues and monomolecular films.
Advances in experimental medicine and biology 1977;84():191-208.
1976: Jochen Schacht
Inhibition by neomycin of polyphosphoinositide turnover in subcellular fractions of guinea-pig cerebral cortex in vitro.
Journal of neurochemistry 1976;27(5):1119-24.
1976: A D Springer; Jochen Schacht; B W Agranoff
The effect of memory blocking antibiotics and their analogs on acetylcholinesterase.
Pharmacology, biochemistry, and behavior 1976;5(1):1-3.
1976: S Lodhi; N D Weiner; Jochen Schacht
Interactions of neomycin and calcium in synaptosomal membranes and polyphosphoinostide monolayers.
Biochimica et biophysica acta 1976;426(4):781-5.
1976: Jochen Schacht
Biochemistry of neomycin ototoxicity.
The Journal of the Acoustical Society of America 1976;59(4):940-4.
1976: A Orsulakova; E Stockhorst; Jochen Schacht
Effect of neomycin on phosphoinositide labelling and calcium binding in guinea-pig inner ear tissues in vivo and in vitro.
Journal of neurochemistry 1976;26(2):285-90.
1975: R E Preston; L G Johnsson; J H Hill; Jochen Schacht
Incorporation of radioactive calcium into otolithic membranes and middle ear ossicles of the gerbil.
Acta oto-laryngologica 1975;80(3-4):269-75.
1974: Jochen Schacht
Interaction of neomycin with phosphoinositide metabolism in guinea pig inner ear and brain tissues.
The Annals of otology, rhinology, and laryngology 1974;83(5):613-8.
1974: Jochen Schacht; E A Neale; B W Agranoff
Cholinergic stimulation of phospholipid labelling from (32P) orthophosphate in guinea-pig cortex synaptosomes in vitro: subsynaptosomal localization.
Journal of neurochemistry 1974;23(1):211-8.
1974: Jochen Schacht; B W Agranoff
Detergent-like action of tetraphenylborate on phospholipid labelling in guinea pig cortex subfractions.
Journal of neurochemistry 1974;22(4):473-8.
1974: Jochen Schacht; B W Agranoff
Stimulation of hydrolysis of phosphatidic acid by cholinergic agents in guinea pig synaptosomes.
The Journal of biological chemistry 1974;249(5):1551-7.
1973: Jochen Schacht; B W Agranoff
Acetylcholine stimulates hydrolysis of 32 P-labeled phosphatidic acid in guinea pig synaptosomes.
Biochemical and biophysical research communications 1973;50(3):934-41.
1972: Jochen Schacht; B W Agranoff
Phospholipid labelling by ( 32 P)-orthophosphate and ( 3 H)-myo-inositol in the stimulated goldfish brain in vivo.
Journal of neurochemistry 1972;19(5):1417-21.
1972: Jochen Schacht; B W Agranoff
Effects of acetylcholine on labeling of phosphatidate and phosphoinositides by ( 32 P) orthophosphate in nerve ending fractions of guinea pig cortex.
The Journal of biological chemistry 1972;247(3):771-7.