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Harry Schachter
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17
Sarkar, Mohan
16
Brockhausen, Inka
9
Paulsen, Hans
8
Tan, Jenny
7
Zhang, Wenli
6
Spence, Andrew
5
Vajsar, Jiri
4
Reinhold, Vernon
4
Chen, Shihao
4
Glössl, Josef
3
Fan, Xiaolian
3
Mahuran, Don
3
Chen, SH
3
Bagshaw, Richard
3
Mucha, Jan
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All Publications
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2009: Schachter Harry
Paucimannose N-glycans in Caenorhabditis elegans and Drosophila melanogaster.
Carbohydrate research 2009;344(12):1391-6.
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2008: Clement Emma M; Godfrey Caroline; Tan Jenny; Brockington Martin; Torelli Silvia; Feng Lucy; Brown Susan C; Jimenez-Mallebrera Cecilia; Sewry Caroline A; Longman Cheryl; Mein Rachael; Abbs Steve; Vajsar Jiri; Schachter Harry; Muntoni Francesco
Mild POMGnT1 mutations underlie a novel limb-girdle muscular dystrophy variant.
Archives of neurology 2008;65(1):137-41.
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2006: Sarkar Mohan; Leventis Peter A; Silvescu Cristina I; Reinhold Vernon N; Schachter Harry; Boulianne Gabrielle L
Null mutations in Drosophila N-acetylglucosaminyltransferase I produce defects in locomotion and a reduced life span.
The Journal of biological chemistry 2006;281(18):12776-85.
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2006: Vajsar Jiri; Zhang Wenli; Dobyns William B; Biggar Doug; Holden Kenton R; Hawkins Cynthia; Ray Peter; Olney Ann H; Burson Catherine M; Srivastava Anand K; Schachter Harry
Carriers and patients with muscle-eye-brain disease can be rapidly diagnosed by enzymatic analysis of fibroblasts and lymphoblasts.
Neuromuscular disorders : NMD 2006;16(2):132-6.
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2006: Shi Hui; Tan Jenny; Schachter Harry
N-glycans are involved in the response of Caenorhabditis elegans to bacterial pathogens.
Methods in enzymology 2006;417():359-89.
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2006: Vajsar Jiri; Schachter Harry
Walker-Warburg syndrome.
Orphanet journal of rare diseases 2006;1():29.
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2005: Schachter Harry
The search for glycan function: fucosylation of the TGF-beta1 receptor is required for receptor activation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):15721-2.
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2005: Fan Xiaolian; She Yi-Min; Bagshaw Richard D; Callahan John W; Schachter Harry; Mahuran Don J
Identification of the hydrophobic glycoproteins of Caenorhabditis elegans.
Glycobiology 2005;15(10):952-64.
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2004: Schachter Harry
Protein glycosylation lessons from Caenorhabditis elegans.
Current opinion in structural biology 2004;14(5):607-16.
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2004: Fan Xiaolian; She Yi-Min; Bagshaw Rick D; Callahan John W; Schachter Harry; Mahuran Don J
A method for proteomic identification of membrane-bound proteins containing Asn-linked oligosaccharides.
Analytical biochemistry 2004;332(1):178-86.
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2004: Zhu Shaoxian; Hanneman Andrew; Reinhold Vernon N; Spence Andrew M; Schachter Harry
Caenorhabditis elegans triple null mutant lacking UDP-N-acetyl-D-glucosamine:alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I.
The Biochemical journal 2004;382(Pt 3):995-1001.
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2004: Schachter Harry; Vajsar Jiri; Zhang Wenli
The role of defective glycosylation in congenital muscular dystrophy.
Glycoconjugate journal 2004;20(5):291-300.
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2003: Zhang Wenli; Vajsar Jiri; Cao Pinjiang; Breningstall Galen; Diesen Charlotta; Dobyns William; Herrmann Ralph; Lehesjoki Anna-Elina; Steinbrecher Alice; Talim Beril; Toda Tatsushi; Topaloglu Haluk; Voit Thomas; Schachter Harry
Enzymatic diagnostic test for Muscle-Eye-Brain type congenital muscular dystrophy using commercially available reagents.
Clinical biochemistry 2003;36(5):339-44.
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2003: Zhang Wenli; Cao Pinjiang; Chen Shihao; Spence Andrew M; Zhu Shaoxian; Staudacher Erika; Schachter Harry
Synthesis of paucimannose N-glycans by Caenorhabditis elegans requires prior actions of UDP-N-acetyl-D-glucosamine:alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I, alpha3,6-mannosidase II and a specific membrane-bound beta-N-acetylglucosaminidase.
The Biochemical journal 2003;372(Pt 1):53-64.
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2003: Chen Shihao; Spence Andrew M; Schachter Harry
Isolation of null alleles of the Caenorhabditis elegans gly-12, gly-13 and gly-14 genes, all of which encode UDP-GlcNAc: alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I activity.
Biochimie 2003;85(3-4):391-401.
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2003: Pagny S; Bouissonnie F; Sarkar M; Follet-Gueye M L; Driouich A; Schachter H; Faye L; Gomord V
Structural requirements for Arabidopsis beta1,2-xylosyltransferase activity and targeting to the Golgi.
The Plant journal : for cell and molecular biology 2003;33(1):189-203.
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2003: Schachter Harry; Reck Folkert; Paulsen Hans
Use of synthetic oligosaccharide substrate analogs to map the active sites of N-acetylglucosaminyltransferases I and II.
Methods in enzymology 2003;363():459-75.
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2002: Schachter Harry
The role of the GlcNAc(beta)1,2Man(alpha)- moiety in mammalian development. Null mutations of the genes encoding UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I and UDP-N-acetylglucosamine:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2 cause embryonic lethality and congenital muscular dystrophy in mice and men, respectively.
Biochimica et biophysica acta 2002;1573(3):292-300.
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2002: Chen Shihao; Tan Jenny; Reinhold Vernon N; Spence Andrew M; Schachter Harry
UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I and UDP-N-acetylglucosamine:alpha-6-D-mannoside beta-1,2-N-acetylglucosaminyltransferase II in Caenorhabditis elegans.
Biochimica et biophysica acta 2002;1573(3):271-9.
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2002: Mucha Jan; Svoboda Barbara; Kappel Sonja; Strasser Richard; Bencur Peter; Fröhwein Ulrike; Schachter Harry; Mach Lukas; Glössl Josef
Two closely related forms of UDP-GlcNAc: alpha6-D-mannoside beta1,2-N-acetylglucosaminyltransferase II occur in the clawed frog Xenopus laevis.
Glycoconjugate journal 2002;19(3):187-95.
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2002: Zhang Wenli; Betel Doron; Schachter Harry
Cloning and expression of a novel UDP-GlcNAc:alpha-D-mannoside beta1,2-N-acetylglucosaminyltransferase homologous to UDP-GlcNAc:alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I.
The Biochemical journal 2002;361(Pt 1):153-62.
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2002: Schachter Harry; Chen Shihao; Zhang Wenli; Spence Andrew M; Zhu Shaoxian; Callahan John W; Mahuran Don J; Fan Xiaolian; Bagshaw Rick D; She Yi-Min; Rosa J Cesar; Reinhold Vernon N
Functional post-translational proteomics approach to study the role of N-glycans in the development of Caenorhabditis elegans.
Biochemical Society symposium 2002;(69):1-21.
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2001: Schachter H
The clinical relevance of glycobiology.
The Journal of clinical investigation 2001;108(11):1579-82.
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2001: Mucha J; Svoboda B; Fröhwein U; Strasser R; Mischinger M; Schwihla H; Altmann F; Hane W; Schachter H; Glössl J; Mach L
Tissues of the clawed frog Xenopus laevis contain two closely related forms of UDP-GlcNAc:alpha3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.
Glycobiology 2001;11(9):769-78.
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2001: Schachter H
Congenital disorders involving defective N-glycosylation of proteins.
Cellular and molecular life sciences : CMLS 2001;58(8):1085-104.
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2001: Sarkar M; Schachter H
Cloning and expression of Drosophila melanogaster UDP-GlcNAc:alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I.
Biological chemistry 2001;382(2):209-17.
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2000: Egan S; Cohen B; Sarkar M; Ying Y; Cohen S; Singh N; Wang W; Flock G; Goh T; Schachter H
Molecular cloning and expression analysis of a mouse UDP-GlcNAc:Gal(beta1-4)Glc(NAc)-R beta1,3-N-acetylglucosaminyltransferase homologous to Drosophila melanogaster Brainiac and the beta1,3-galactosyltransferase family.
Glycoconjugate journal 2000;17(12):867-75.
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2000: Unligil U M; Zhou S; Yuwaraj S; Sarkar M; Schachter H; Rini J M
X-ray crystal structure of rabbit N-acetylglucosaminyltransferase I: catalytic mechanism and a new protein superfamily.
The EMBO journal 2000;19(20):5269-80.
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2000: Schachter H
The joys of HexNAc. The synthesis and function of N- and O-glycan branches.
Glycoconjugate journal 2000;17(7-9):465-83.
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2000: Zhang W; Revers L; Pierce M; Schachter H
Regulation of expression of the human beta-1,2-N-acetylglucosaminyltransferase II gene (MGAT2) by Ets transcription factors.
The Biochemical journal 2000;347(Pt 2):511-8.
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1999: Schachter H; Jaeken J
Carbohydrate-deficient glycoprotein syndrome type II.
Biochimica et biophysica acta 1999;1455(2-3):179-92.
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1999: Chen S; Zhou S; Sarkar M; Spence A M; Schachter H
Expression of three Caenorhabditis elegans N-acetylglucosaminyltransferase I genes during development.
The Journal of biological chemistry 1999;274(1):288-97.
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1998: Chen S H; Zhou S; Tan J; Schachter H
Transcriptional regulation of the human UDP-GlcNAc:alpha-6-D-mannoside beta-1-2-N-acetylglucosaminyltransferase II gene (MGAT2) which controls complex N-glycan synthesis.
Glycoconjugate journal 1998;15(3):301-8.
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1998: Sarkar M; Pagny S; Unligil U; Joziasse D; Mucha J; Glössl J; Schachter H
Removal of 106 amino acids from the N-terminus of UDP-GlcNAc: alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I does not inactivate the enzyme.
Glycoconjugate journal 1998;15(2):193-7.
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1998: Kameh H; Landolt-Marticorena C; Charuk J H; Schachter H; Reithmeier R A
Structural and functional consequences of an N-glycosylation mutation (HEMPAS) affecting human erythrocyte membrane glycoproteins.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1998;76(5):823-35.
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1998: Schachter H; Tan J; Sarkar M; Yip B; Chen S; Dunn J; Jaeken J
Defective glycosyltransferases are not good for your health.
Advances in experimental medicine and biology 1998;435():9-27.
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1997: Schachter H; Chen S H; Zhou S; Tan J; Yip B; Sarkar M; Spence A
Structure and function of the genes encoding N-acetylglucosaminyltransferases which initiate N-glycan antennae.
Biochemical Society transactions 1997;25(3):875-80.
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1997: Toki D; Sarkar M; Yip B; Reck F; Joziasse D; Fukuda M; Schachter H; Brockhausen I
Expression of stable human O-glycan core 2 beta-1,6-N-acetylglucosaminyltransferase in Sf9 insect cells.
The Biochemical journal 1997;325 ( Pt 1)():63-9.
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1997: Yip B; Chen S H; Mulder H; Höppener J W; Schachter H
Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis.
The Biochemical journal 1997;321 ( Pt 2)():465-74.
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1997: Taguchi T; Kitajima K; Inoue S; Inoue Y; Yang J M; Schachter H; Brockhausen I
Activity of UDP-GlcNAc:GlcNAc beta 1-->6(GlcNAc beta 1-->2) Man alpha 1-->R[GlcNAc to Man] beta 1-->4N-acetylglucosaminyltransferase VI (GnT VI) from the ovaries of Oryzias latipes (Medaka fish).
Biochemical and biophysical research communications 1997;230(3):533-6.
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1996: Tan J; Dunn J; Jaeken J; Schachter H
Mutations in the MGAT2 gene controlling complex N-glycan synthesis cause carbohydrate-deficient glycoprotein syndrome type II, an autosomal recessive disease with defective brain development.
American journal of human genetics 1996;59(4):810-7.
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1995: Reck F; Springer M; Meinjohanns E; Paulsen H; Brockhausen I; Schachter H
Synthetic substrate analogues for UDP-GlcNAc: Man alpha 1-3R beta 1-2-N-acetylglucosaminyltransferase I. Substrate specificity and inhibitors for the enzyme.
Glycoconjugate journal 1995;12(6):747-54.
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1995: Paulsen H; Springer M; Reck F; Brockhausen I; Schachter H
[Synthesis of modified tetrasaccharides as analog acceptor-inhibitors of N-acetylglucosaminyltransferase II]
Carbohydrate research 1995;275(2):403-11.
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1995: Reck F; Meinjohanns E; Tan J; Grey A A; Paulsen H; Schachter H
Synthesis of pentasaccharide analogues of the N-glycan substrates of N-acetylglucosaminyltransferases III, IV and V using tetrasaccharide precursors and recombinant beta-(1-->2)-N-acetylglucosaminyltransferase II.
Carbohydrate research 1995;275(2):221-9.
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1995: Tan J; D'Agostaro A F; Bendiak B; Reck F; Sarkar M; Squire J A; Leong P; Schachter H
The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein.
European journal of biochemistry / FEBS 1995;231(2):317-28.
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1995: D'Agostaro G A; Zingoni A; Moritz R L; Simpson R J; Schachter H; Bendiak B
Molecular cloning and expression of cDNA encoding the rat UDP-N-acetylglucosamine:alpha-6-D-mannoside beta-1,2-N-acetylglucosaminyltransferase II.
The Journal of biological chemistry 1995;270(25):15211-21.
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1995: Charuk J H; Tan J; Bernardini M; Haddad S; Reithmeier R A; Jaeken J; Schachter H
Carbohydrate-deficient glycoprotein syndrome type II. An autosomal recessive N-acetylglucosaminyltransferase II deficiency different from typical hereditary erythroblastic multinuclearity, with a positive acidified-serum lysis test (HEMPAS).
European journal of biochemistry / FEBS 1995;230(2):797-805.
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1995: Brockhausen I; Reck F; Kuhns W; Khan S; Matta K L; Meinjohanns E; Paulsen H; Shah R N; Baker M A; Schachter H
Substrate specificity and inhibition of UDP-GlcNAc:GlcNAc beta 1-2Man alpha 1-6R beta 1,6-N-acetylglucosaminyltransferase V using synthetic substrate analogues.
Glycoconjugate journal 1995;12(3):371-9.
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1995: Kalsner I; Hintz W; Reid L S; Schachter H
Insertion into Aspergillus nidulans of functional UDP-GlcNAc: alpha 3-D- mannoside beta-1,2-N-acetylglucosaminyl-transferase I, the enzyme catalysing the first committed step from oligomannose to hybrid and complex N-glycans.
Glycoconjugate journal 1995;12(3):360-70.
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1994: Reck F; Springer M; Paulsen H; Brockhausen I; Sarkar M; Schachter H
Synthesis of tetrasaccharide analogues of the N-glycan substrate of beta-(1-->2)-N-acetylglucosaminyltransferase II using trisaccharide precursors and recombinant beta-(1-->2)-N-acetylglucosaminyltransferase I.
Carbohydrate research 1994;259(1):93-101.
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1994: Reck F; Meinjohanns E; Springer M; Wilkens R; Van Dorst J A; Paulsen H; Möller G; Brockhausen I; Schachter H
Synthetic substrate analogues for UDP-GlcNAc: Man alpha 1-6R beta(1-2)-N-acetylglucosaminyltransferase II. Substrate specificity and inhibitors for the enzyme.
Glycoconjugate journal 1994;11(3):210-6.
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1994: Metzler M; Gertz A; Sarkar M; Schachter H; Schrader J W; Marth J D
Complex asparagine-linked oligosaccharides are required for morphogenic events during post-implantation development.
The EMBO journal 1994;13(9):2056-65.
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1992: Brockhausen I; Möller G; Yang J M; Khan S H; Matta K L; Paulsen H; Grey A A; Shah R N; Schachter H
Control of glycoprotein synthesis. Characterization of (1-->4)-N-acetyl-beta-D-glucosaminyltransferases acting on the alpha-D-(1-->3)- and alpha-D-(1-->6)-linked arms of N-linked oligosaccharides.
Carbohydrate research 1992;236():281-99.
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1992: Möller G; Reck F; Paulsen H; Kaur K J; Sarkar M; Schachter H; Brockhausen I
Control of glycoprotein synthesis: substrate specificity of rat liver UDP-GlcNAc:Man alpha 3R beta 2-N-acetylglucosaminyltransferase I using synthetic substrate analogues.
Glycoconjugate journal 1992;9(4):180-90.
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1992: Pownall S; Kozak C A; Schappert K; Sarkar M; Hull E; Schachter H; Marth J D
Molecular cloning and characterization of the mouse UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene.
Genomics 1992;12(4):699-704.
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1991: Schachter H
The 'yellow brick road' to branched complex N-glycans.
Glycobiology 1991;1(5):453-61.
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1991: Staudacher E; Altmann F; Glössl J; März L; Schachter H; Kamerling J P; Hård K; Vliegenthart J F
GDP-fucose: beta-N-acetylglucosamine (Fuc to (Fuc alpha 1----6GlcNAc)-Asn-peptide)alpha 1----3-fucosyltransferase activity in honeybee (Apis mellifica) venom glands. The difucosylation of asparagine-bound N-acetylglucosamine.
European journal of biochemistry / FEBS 1991;199(3):745-51.
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1991: Schachter H; Hull E; Sarkar M; Simpson R J; Moritz R L; Höppener J W; Dunn R
Molecular cloning of human and rabbit UDP-N-acetylglucosamine: alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.
Biochemical Society transactions 1991;19(3):645-8.
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1991: Hull E; Sarkar M; Spruijt M P; Höppener J W; Dunn R; Schachter H
Organization and localization to chromosome 5 of the human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene.
Biochemical and biophysical research communications 1991;176(2):608-15.
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1991: Brockhausen I; Kuhns W; Schachter H; Matta K L; Sutherland D R; Baker M A
Biosynthesis of O-glycans in leukocytes from normal donors and from patients with leukemia: increase in O-glycan core 2 UDP-GlcNAc:Gal beta 3 GalNAc alpha-R (GlcNAc to GalNAc) beta(1-6)-N-acetylglucosaminyltransferase in leukemic cells.
Cancer research 1991;51(4):1257-63.
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1991: Sarkar M; Hull E; Nishikawa Y; Simpson R J; Moritz R L; Dunn R; Schachter H
Molecular cloning and expression of cDNA encoding the enzyme that controls conversion of high-mannose to hybrid and complex N-glycans: UDP-N-acetylglucosamine: alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(1):234-8.
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1989: Brockhausen I; Hull E; Hindsgaul O; Schachter H; Shah R N; Michnick S W; Carver J P
Control of glycoprotein synthesis. Detection and characterization of a novel branching enzyme from hen oviduct, UDP-N-acetylglucosamine:GlcNAc beta 1-6 (GlcNAc beta 1-2)Man alpha-R (GlcNAc to Man) beta-4-N-acetylglucosaminyltransferase VI.
The Journal of biological chemistry 1989;264(19):11211-21.
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1989: Schachter H; Brockhausen I
The biosynthesis of branched O-glycans.
Symposia of the Society for Experimental Biology 1989;43():1-26.
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1989: Schachter H; Brockhausen I; Hull E
High-performance liquid chromatography assays for N-acetylglucosaminyltransferases involved in N- and O-glycan synthesis.
Methods in enzymology 1989;179():351-97.
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1988: Brockhausen I; Narasimhan S; Schachter H
The biosynthesis of highly branched N-glycans: studies on the sequential pathway and functional role of N-acetylglucosaminyltransferases I, II, III, IV, V and VI.
Biochimie 1988;70(11):1521-33.
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1988: Brockhausen I; Carver J P; Schachter H
Control of glycoprotein synthesis. The use of oligosaccharide substrates and HPLC to study the sequential pathway for N-acetylglucosaminyltransferases I, II, III, IV, V, and VI in the biosynthesis of highly branched N-glycans by hen oviduct membranes.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1988;66(10):1134-51.
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1988: Narasimhan S; Lee J W; Cheung R K; Gelfand E W; Schachter H
Beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase III activity in human B and T lymphocyte lines and in tonsillar B and T lymphocytes.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1988;66(8):889-900.
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1988: Nishikawa Y; Pegg W; Paulsen H; Schachter H
Control of glycoprotein synthesis. Purification and characterization of rabbit liver UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.
The Journal of biological chemistry 1988;263(17):8270-81.
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1988: Narasimhan S; Schachter H; Rajalakshmi S
Expression of N-acetylglucosaminyltransferase III in hepatic nodules during rat liver carcinogenesis promoted by orotic acid.
The Journal of biological chemistry 1988;263(3):1273-81.
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1987: Bendiak B; Schachter H
Control of glycoprotein synthesis. Kinetic mechanism, substrate specificity, and inhibition characteristics of UDP-N-acetylglucosamine:alpha-D-mannoside beta 1-2 N-acetylglucosaminyltransferase II from rat liver.
The Journal of biological chemistry 1987;262(12):5784-90.
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1987: Bendiak B; Schachter H
Control of glycoprotein synthesis. Purification of UDP-N-acetylglucosamine:alpha-D-mannoside beta 1-2 N-acetylglucosaminyltransferase II from rat liver.
The Journal of biological chemistry 1987;262(12):5775-83.
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1983: Schachter H; Narasimhan S; Gleeson P; Vella G
Control of branching during the biosynthesis of asparagine-linked oligosaccharides.
Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire 1983;61(9):1049-66.
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1983: Schachter H; Narasimhan S; Gleeson P; Vella G
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
Methods in enzymology 1983;98():98-134.
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1982: Schachter H; Narasimhan S; Gleeson P; Vella G J; Brockhausen I
Oligosaccharide branching of glycoproteins: biosynthetic mechanisms and possible biological functions.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1982;300(1099):145-59.
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