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Jean Schaffer

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Joel D Schilling; Abhinav Diwan; Li He; Heather M Machkovech; Jean E Schaffer
TLR4 activation under lipotoxic conditions leads to synergistic macrophage cell death through a TRIF-dependent pathway.
Joel D Schilling; Rohini Sidhu; Kassandra Weber; Hideji Fujiwara; Li He; Heather M Machkovech; Daniel S Ory; Jean E Schaffer
Palmitate and lipopolysaccharide trigger synergistic ceramide production in primary macrophages.
Joel D Schilling; Reto Schwedwener; Reto Schwendener; Alfred H J Kim; Heather M Machkovech; Jean E Schaffer
Macrophages modulate cardiac function in lipotoxic cardiomyopathy.

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All Publications

2013: Joel D Schilling; Abhinav Diwan; Li He; Heather M Machkovech; Jean E Schaffer
TLR4 activation under lipotoxic conditions leads to synergistic macrophage cell death through a TRIF-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(3):1285-96.
2013: Joel D Schilling; Rohini Sidhu; Kassandra Weber; Hideji Fujiwara; Li He; Heather M Machkovech; Daniel S Ory; Jean E Schaffer
Palmitate and lipopolysaccharide trigger synergistic ceramide production in primary macrophages.
The Journal of biological chemistry 2013;288(5):2923-32.
2012: Joel D Schilling; Reto Schwedwener; Reto Schwendener; Alfred H J Kim; Heather M Machkovech; Jean E Schaffer
Macrophages modulate cardiac function in lipotoxic cardiomyopathy.
American journal of physiology. Heart and circulatory physiology 2012;303(11):H1366-73.
2012: Benjamin S Scruggs; Carlos I Michel; Daniel S Ory; Jean E Schaffer
SmD3 regulates intronic noncoding RNA biogenesis.
Molecular and cellular biology 2012;32(20):4092-103.
2012: Linda R Peterson; Clark R McKenzie; Jean E Schaffer
Diabetic cardiovascular disease: getting to the heart of the matter.
Journal of cardiovascular translational research 2012;5(4):436-45.
2011: Carlos I Michel; Daniel S Ory; Benjamin S Scruggs; Rohini Sidhu; Mark A Behlke; Rita T Brookheart; Christopher L Holley; Laura L Listenberger; Jean E Schaffer
Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress.
Cell metabolism 2011;14(1):33-44.
2011: Xuntian Jiang; Dennis J Dietzen; Hideji Fujiwara; Frances M Platt; Forbes D Porter; Jean E Schaffer; David E Scherrer; Rohini Sidhu; Anneliese O Speak; Danielle Taylor te Vruchte; Nicole M Yanjanin; Jessie Zhang; Daniel S Ory
A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma.
Journal of lipid research 2011;52(7):1435-45.
2011: Christian C Anderson; Allyson A Gibson; Jean E Schaffer; Linda R Peterson; Mark R Holland; James G Miller
Bayesian parameter estimation for characterizing the cyclic variation of echocardiographic backscatter to assess the hearts of asymptomatic type 2 diabetes mellitus subjects.
Ultrasound in medicine & biology 2011;37(5):805-12.
2010: Mark R Holland; Allyson A Gibson; Adam Q Bauer; Linda R Peterson; Jean E Schaffer; Richard G Bach; Sharon Cresci; James G Miller
Echocardiographic tissue characterization demonstrates differences in the left and right sides of the ventricular septum.
Ultrasound in medicine & biology 2010;36(10):1653-61.
2009: Allyson A Gibson; Jean E Schaffer; Linda Peterson; Kyle R Bilhorn; Karla M Robert; Troy A Haider; Marsha S Farmer; Mark R Holland; James G Miller
Quantitative analysis of the magnitude and time delay of cyclic variation of myocardial backscatter from asymptomatic type 2 diabetes mellitus subjects.
Ultrasound in medicine & biology 2009;35(9):1458-67.
2009: Rita T Brookheart; Carlos I Michel; Jean E Schaffer
As a matter of fat.
Cell metabolism 2009;10(1):9-12.
2009: Rita T Brookheart; Carlos I Michel; Laura L Listenberger; Daniel S Ory; Jean E Schaffer
The non-coding RNA gadd7 is a regulator of lipid-induced oxidative and endoplasmic reticulum stress.
The Journal of biological chemistry 2009;284(12):7446-54.
2008: Mark Gelsthorpe; Nikola A. Baumann; Elizabeth Millard; Sarah E Gale; S Joshua Langmade; Jean E Schaffer; Daniel S Ory
Niemann-Pick type C1 I1061T mutant encodes a functional protein that is selected for endoplasmic reticulum-associated degradation due to protein misfolding.
The Journal of biological chemistry 2008;283(13):8229-36.
2006: Nica M Borradaile; Xianlin Han; Jeffrey D Harp; Sarah E Gale; Daniel S Ory; Jean E Schaffer
Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death.
Journal of lipid research 2006;47(12):2726-37.
2006: S Joshua Langmade; Sarah E Gale; Andrey Frolov; Ikuko Mohri; Kinuko Suzuki; Synthia H Mellon; Steven U Walkley; Douglas F Covey; Jean E Schaffer; Daniel S Ory
Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(37):13807-12.
2006: Sarah E Gale; Andrey Frolov; Xianlin Han; Perry E Bickel; Li Cao; Anne M Bowcock; Jean E Schaffer; Daniel S Ory
A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation.
The Journal of biological chemistry 2006;281(16):11082-9.
2006: M Rachel Richards; Jeffrey D Harp; Daniel S Ory; Jean E Schaffer
Fatty acid transport protein 1 and long-chain acyl coenzyme A synthetase 1 interact in adipocytes.
Journal of lipid research 2006;47(3):665-72.
2006: Nica M Borradaile; Kimberly Buhman; Laura L Listenberger; Carolyn J Magee; Emiko T A Morimoto; Daniel S Ory; Jean E Schaffer
A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death.
Molecular biology of the cell 2006;17(2):770-8.
2005: Nica M Borradaile; Jean E Schaffer
Lipotoxicity in the heart.
Current hypertension reports 2005;7(6):412-7.
2005: Elizabeth E Millard; Sarah E Gale; Nicole Dudley; Jessie Zhang; Jean E Schaffer; Daniel S Ory
The sterol-sensing domain of the Niemann-Pick C1 (NPC1) protein regulates trafficking of low density lipoprotein cholesterol.
The Journal of biological chemistry 2005;280(31):28581-90.
2005: Hsiu-Chiang Chiu; Attila Kovacs; Robert M Blanton; Xianlin Han; Michael Courtois; Carla Weinheimer; Kathryn A Yamada; Sylvain Brunet; Haodong Xu; Jeanne M Nerbonne; Michael J Welch; Nicole M Fettig; Terry L Sharp; Nandakumar Sambandam; Krista M Olson; Daniel S Ory; Jean E Schaffer
Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy.
Circulation research 2005;96(2):225-33.
2004: Douglas G Mashek; Karin E Bornfeldt; Rosalind A Coleman; Johannes Berger; David A Bernlohr; Paul Black; Concetta C DiRusso; Steven A Farber; Wen Guo; Naohiro Hashimoto; Varsha K Khodiyar; Frans A Kuypers; Lois J Maltais; Daniel W Nebert; Alessandra Renieri; Jean E Schaffer; Andreas Stahl; Paul A Watkins; Vasilis Vasiliou; Tokuo T Yamamoto
Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family.
Journal of lipid research 2004;45(10):1958-61.
2004: Jessie Zhang; Nicole Dudley-Rucker; Jan R Crowley; Elvira Lopez-Perez; Marc Issandou; Jean E Schaffer; Daniel S Ory
The steroidal analog GW707 activates the SREBP pathway through disruption of intracellular cholesterol trafficking.
Journal of lipid research 2004;45(2):223-31.
2003: Andrey Frolov; Sarah E Zielinski; Jan R Crowley; Nicole Dudley-Rucker; Jean E Schaffer; Daniel S Ory
NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols.
The Journal of biological chemistry 2003;278(28):25517-25.
2003: Jean E Schaffer
Lipotoxicity: when tissues overeat.
Current opinion in lipidology 2003;14(3):281-7.
2003: M Rachel Richards; Laura L Listenberger; Alicia A Kelly; Sarah E Lewis; Daniel S Ory; Jean E Schaffer
Oligomerization of the murine fatty acid transport protein 1.
The Journal of biological chemistry 2003;278(12):10477-83.
2003: Laura L Listenberger; Xianlin Han; Sarah E Lewis; Sylvaine Cases; Robert V Farese; Daniel S Ory; Jean E Schaffer
Triglyceride accumulation protects against fatty acid-induced lipotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(6):3077-82.
2002: Laura L Listenberger; Jean E Schaffer
Mechanisms of lipoapoptosis: implications for human heart disease.
Trends in cardiovascular medicine 2002;12(3):134-8.
2002: Ilaria Meloni; Michela Muscettola; Martine Raynaud; Ilaria Longo; Mirella Bruttini; Marie-Pierre Moizard; Marie Gomot; Jamel Chelly; Vincent des Portes; Jean-Pierre Fryns; Hans-Hilger Ropers; Barbara Magi; Cristina Bellan; Nila Volpi; Helger G Yntema; Sarah E Lewis; Jean E Schaffer; Alessandra Renieri
FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation.
Nature genetics 2002;30(4):436-40.
2002: Jean E Schaffer
Fatty acid transport: the roads taken.
American journal of physiology. Endocrinology and metabolism 2002;282(2):E239-46.
2001: Andrey Frolov; K Srivastava; D Daphna-Iken; Linton Traub; Jean E Schaffer; Daniel S Ory
Cholesterol overload promotes morphogenesis of a Niemann-Pick C (NPC)-like compartment independent of inhibition of NPC1 or HE1/NPC2 function.
The Journal of biological chemistry 2001;276(49):46414-21.
2001: Sarah E Lewis; Laura L Listenberger; Daniel S Ory; Jean E Schaffer
Membrane topology of the murine fatty acid transport protein 1.
The Journal of biological chemistry 2001;276(40):37042-50.
2001: Laura L Listenberger; Daniel S Ory; Jean E Schaffer
Palmitate-induced apoptosis can occur through a ceramide-independent pathway.
The Journal of biological chemistry 2001;276(18):14890-5.
2001: H C Chiu; Attila Kovacs; D A Ford; F F Hsu; R Garcia; P Herrero; J E Saffitz; Jean E Schaffer
A novel mouse model of lipotoxic cardiomyopathy.
The Journal of clinical investigation 2001;107(7):813-22.
2000: E E Millard; K Srivastava; Linton Traub; Jean E Schaffer; Daniel S Ory
Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis.
The Journal of biological chemistry 2000;275(49):38445-51.
1999: SM Stuhlsatz-Krouper; N E Bennett; Jean E Schaffer
Molecular aspects of fatty acid transport: mutations in the IYTSGTTGXPK motif impair fatty acid transport protein function.
Prostaglandins, leukotrienes, and essential fatty acids 1999;60(5-6):285-9.
1999: C E Gargiulo; SM Stuhlsatz-Krouper; Jean E Schaffer
Localization of adipocyte long-chain fatty acyl-CoA synthetase at the plasma membrane.
Journal of lipid research 1999;40(5):881-92.
1998: SM Stuhlsatz-Krouper; N E Bennett; Jean E Schaffer
Substitution of alanine for serine 250 in the murine fatty acid transport protein inhibits long chain fatty acid transport.
The Journal of biological chemistry 1998;273(44):28642-50.
1998: TY Hui; BI Frohnert; Anne J Smith; Jean E Schaffer; David A Bernlohr
Characterization of the murine fatty acid transport protein gene and its insulin response sequence.
The Journal of biological chemistry 1998;273(42):27420-9.