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Brian Schaffhausen

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Cell Transformation, Viral

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Shaida Andrabi; Jennifer Kean Choe; Justin H Hwang; Thomas M Roberts; Brian Schaffhausen
Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function.
Sang Hyun Lee; Shidong Jia; Yanni Zhu; Tamara Utermark; Sabina Signoretti; Massimo Loda; Brian Schaffhausen; Thomas M Roberts
Transgenic expression of polyomavirus middle T antigen in the mouse prostate gives rise to carcinoma.
Benchun Miao; Igor Skidan; Jinsheng Yang; Alexey Lugovskoy; Mikhail Reibarkh; Kai Long; Tres Brazell; Kulbhushan A Durugkar; Jenny Maki; C V Ramana; Brian Schaffhausen; Gerhard Wagner; Vladimir Torchilin; Junying Yuan; Alexei Degterev
Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.

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All Publications

2011: Shaida Andrabi; Jennifer Kean Choe; Justin H Hwang; Thomas M Roberts; Brian Schaffhausen
Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function.
Journal of virology 2011;85(20):10649-58.
2011: Sang Hyun Lee; Shidong Jia; Yanni Zhu; Tamara Utermark; Sabina Signoretti; Massimo Loda; Brian Schaffhausen; Thomas M Roberts
Transgenic expression of polyomavirus middle T antigen in the mouse prostate gives rise to carcinoma.
Journal of virology 2011;85(11):5581-92.
2010: Benchun Miao; Igor Skidan; Jinsheng Yang; Alexey Lugovskoy; Mikhail Reibarkh; Kai Long; Tres Brazell; Kulbhushan A Durugkar; Jenny Maki; C V Ramana; Brian Schaffhausen; Gerhard Wagner; Vladimir Torchilin; Junying Yuan; Alexei Degterev
Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(46):20126-31.
2009: Konstantin Knoblich; Sara Whittaker; Christian Ludwig; Paul Michiels; Tao Jiang; Brian Schaffhausen; Ulrich L Günther
Backbone assignment of the N-terminal polyomavirus large T antigen.
Biomolecular NMR assignments 2009;3(1):119-23.
2009: Brian Schaffhausen; Thomas M Roberts
Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer.
Virology 2009;384(2):304-16.
2008: Stefan K Siwko; Wen Bu; Carolina Gutierrez; Brian Lewis; Martin Jechlinger; Brian Schaffhausen; Yi Li
Lentivirus-mediated oncogene introduction into mammary cells in vivo induces tumors.
Neoplasia (New York, N.Y.) 2008;10(7):653-62, 1 p following 662.
2008: Kerry A Whalen; Georg F Weber; Thomas L Benjamin; Brian Schaffhausen
Polyomavirus middle T antigen induces the transcription of osteopontin, a gene important for the migration of transformed cells.
Journal of virology 2008;82(10):4946-54.
2007: Shaida Andrabi; Ole V Gjoerup; Jennifer A Kean; Thomas M Roberts; Brian Schaffhausen
Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(48):19011-6.
2007: Tamara Utermark; Brian Schaffhausen; Thomas M Roberts; Jean J Zhao
The p110alpha isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation.
Journal of virology 2007;81(13):7069-76.
2007: Ole V Gjoerup; Jiaping Wu; Devin Chandler-Militello; Grace L Williams; Jean Zhao; Brian Schaffhausen; Parmjit S Jat; Thomas M Roberts
Surveillance mechanism linking Bub1 loss to the p53 pathway.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(20):8334-9.
2007: Luca Primo; Laura di Blasio; Cristina Roca; Sara Droetto; Roberto Piva; Brian Schaffhausen; Federico Bussolino
Essential role of PDK1 in regulating endothelial cell migration.
The Journal of cell biology 2007;176(7):1035-47.
2006: Tanja Mittag; Lorella Franzoni; Davide Cavazzini; Brian Schaffhausen; Gian Luigi Rossi; Ulrich L Günther
Retinol modulates site-specific mobility of apo-cellular retinol-binding protein to promote ligand binding.
Journal of the American Chemical Society 2006;128(30):9844-8.
2005: Kerry A Whalen; Rowena de Jesus; Jennifer A Kean; Brian Schaffhausen
Genetic analysis of the polyomavirus DnaJ domain.
Journal of virology 2005;79(15):9982-90.
2005: Tara M Love; Rowena de Jesus; Jennifer A Kean; Qing Sheng; Andrew Leger; Brian Schaffhausen
Activation of CREB/ATF sites by polyomavirus large T antigen.
Journal of virology 2005;79(7):4180-90.
2004: Tanja Mittag; Brian Schaffhausen; Ulrich L Günther
Tracing kinetic intermediates during ligand binding.
Journal of the American Chemical Society 2004;126(29):9017-23.
2004: Aili Lu; Huanqing Zhang; Xiaoyan Zhang; Hongxia Wang; Qikuan Hu; Li Shen; Brian Schaffhausen; Weimin Hou; Linsong Li
Attenuation of SARS coronavirus by a short hairpin RNA expression plasmid targeting RNA-dependent RNA polymerase.
Virology 2004;324(1):84-9.
2003: Tanja Mittag; Brian Schaffhausen; Ulrich L Günther
Direct observation of protein-ligand interaction kinetics.
Biochemistry 2003;42(38):11128-36.
2003: Ulrich L Günther; Bernd Weyrauch; Xinzhe Zhang; Brian Schaffhausen
Nuclear magnetic resonance structure of the P395S mutant of the N-SH2 domain of the p85 subunit of PI3 kinase: an SH2 domain with altered specificity.
Biochemistry 2003;42(38):11120-7.
2003: Y Kate Hong; Aki Mikami; Brian Schaffhausen; Toni Jun; Thomas M Roberts
A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9434-9.
2002: Ulrich L Günther; Tanja Mittag; Brian Schaffhausen
Probing Src homology 2 domain ligand interactions by differential line broadening.
Biochemistry 2002;41(39):11658-69.
2002: Xuejun Tian; Gabriel Rusanescu; Weimin Hou; Brian Schaffhausen; Larry A Feig
PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism.
The EMBO journal 2002;21(6):1327-38.
2002: Ulrich L Günther; Brian Schaffhausen
NMRKIN: simulating line shapes from two-dimensional spectra of proteins upon ligand binding.
Journal of biomolecular NMR 2002;22(3):201-9.
2000: T Weber; Brian Schaffhausen; Y Liu; Ulrich L Günther
NMR structure of the N-SH2 of the p85 subunit of phosphoinositide 3-kinase complexed to a doubly phosphorylated peptide reveals a second phosphotyrosine binding site.
Biochemistry 2000;39(51):15860-9.
2000: Qing Sheng; T M Love; Brian Schaffhausen
J domain-independent regulation of the Rb family by polyomavirus large T antigen.
Journal of virology 2000;74(11):5280-90.
1998: KP Mullane; M Ratnofsky; X Culleré; Brian Schaffhausen
Signaling from polyomavirus middle T and small T defines different roles for protein phosphatase 2A.
Molecular and cellular biology 1998;18(12):7556-64.
1998: M M Chou; W Hou; J Johnson; L K Graham; M H Lee; C S Chen; Alexandra C Newton; Brian Schaffhausen; A Toker
Regulation of protein kinase C zeta by PI 3-kinase and PDK-1.
Current biology : CB 1998;8(19):1069-77.
1998: X Culleré; P Rose; U Thathamangalam; A Chatterjee; KP Mullane; David C Pallas; T L Benjamin; Thomas M Roberts; Brian Schaffhausen
Serine 257 phosphorylation regulates association of polyomavirus middle T antigen with 14-3-3 proteins.
Journal of virology 1998;72(1):558-63.
1997: Qing Sheng; D Denis; M Ratnofsky; Thomas M Roberts; James A DeCaprio; Brian Schaffhausen
The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function.
Journal of virology 1997;71(12):9410-6.
1997: A Chatterjee; B J Bockus; O V Gjørup; Brian Schaffhausen
Phosphorylation sites in polyomavirus large T antigen that regulate its function in viral, but not cellular, DNA synthesis.
Journal of virology 1997;71(9):6472-8.
1997: K S Campbell; KP Mullane; I A Aksoy; H Stubdal; J Zalvide; J M Pipas; P A Silver; Thomas M Roberts; Brian Schaffhausen; James A DeCaprio
DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication.
Genes & development 1997;11(9):1098-110.
1996: U L Günther; Y Liu; D Sanford; W W Bachovchin; Brian Schaffhausen
NMR analysis of interactions of a phosphatidylinositol 3'-kinase SH2 domain with phosphotyrosine peptides reveals interdependence of major binding sites.
Biochemistry 1996;35(48):15570-81.
1996: S H Howes; B J Bockus; Brian Schaffhausen
Genetic analysis of polyomavirus large T nuclear localization: nuclear localization is required for productive association with pRb family members.
Journal of virology 1996;70(6):3581-8.
1995: Brian Schaffhausen
SH2 domain structure and function.
Biochimica et biophysica acta 1995;1242(1):61-75.
1995: W Su; W Liu; Brian Schaffhausen; Thomas M Roberts
Association of Polyomavirus middle tumor antigen with phospholipase C-gamma 1.
The Journal of biological chemistry 1995;270(21):12331-4.
1995: P E Rose; Brian Schaffhausen
Zinc-binding and protein-protein interactions mediated by the polyomavirus large T antigen zinc finger.
Journal of virology 1995;69(5):2842-9.
1995: E K Shin; A Shin; C Paulding; Brian Schaffhausen; Amy Yee
Multiple change in E2F function and regulation occur upon muscle differentiation.
Molecular and cellular biology 1995;15(4):2252-62.
1994: O V Gjørup; P E Rose; P S Holman; B J Bockus; Brian Schaffhausen
Protein domains connect cell cycle stimulation directly to initiation of DNA replication.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):12125-9.
1994: M Yoakim; W Hou; Zhou Songyang; Y Liu; L Cantley; Brian Schaffhausen
Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity.
Molecular and cellular biology 1994;14(9):5929-38.
1994: K S Campbell; Egon Ogris; B Burke; W Su; K R Auger; Brian J Druker; Brian Schaffhausen; Thomas M Roberts; David C Pallas
Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(14):6344-8.
1994: P S Holman; O V Gjoerup; T Davin; Brian Schaffhausen
Characterization of an immortalizing N-terminal domain of polyomavirus large T antigen.
Journal of virology 1994;68(2):668-73.
1994: R Kapeller; Kanteti V Prasad; Ottmar Janssen; W Hou; Brian Schaffhausen; Christopher E Rudd; Lewis C Cantley
Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase.
The Journal of biological chemistry 1994;269(3):1927-33.
1993: Christopher L Carpenter; K R Auger; M Chanudhuri; M Yoakim; Brian Schaffhausen; Steven E Shoelson; Lewis C Cantley
Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit.
The Journal of biological chemistry 1993;268(13):9478-83.
1993: Christopher L Carpenter; K R Auger; Brian Duckworth; W M Hou; Brian Schaffhausen; Lewis C Cantley
A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity.
Molecular and cellular biology 1993;13(3):1657-65.
1992: Martin G Myers Jr; Jonathan M Backer; Xiao Jian Sun; Steven E Shoelson; Patrick J Hu; J Schlessinger; M Yoakim; Brian Schaffhausen; Morris F White
IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10350-4.
1992: M Yoakim; W Hou; Y Liu; Christopher L Carpenter; R Kapeller; Brian Schaffhausen
Interactions of polyomavirus middle T with the SH2 domains of the pp85 subunit of phosphatidylinositol-3-kinase.
Journal of virology 1992;66(9):5485-91.
1992: Stephen Soltoff; Christopher L Carpenter; K R Auger; R Kapeller; Brian Schaffhausen; Lewis C Cantley
Phosphatidylinositol-3 kinase and growth regulation.
Cold Spring Harbor symposia on quantitative biology 1992;57():75-80.
1991: R Kapeller; K S Chen; M Yoakim; Brian Schaffhausen; Jonathan M Backer; Morris F White; Lewis C Cantley; N B Ruderman
Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin.
Molecular endocrinology (Baltimore, Md.) 1991;5(6):769-77.
1990: Christopher L Carpenter; Brian Duckworth; K R Auger; B Cohen; Brian Schaffhausen; Lewis C Cantley
Purification and characterization of phosphoinositide 3-kinase from rat liver.
The Journal of biological chemistry 1990;265(32):19704-11.
1990: B Cohen; Y X Liu; Brian J Druker; Thomas M Roberts; Brian Schaffhausen
Characterization of pp85, a target of oncogenes and growth factor receptors.
Molecular and cellular biology 1990;10(6):2909-15.
1990: B Cohen; M Yoakim; H Piwnica-Worms; Thomas M Roberts; Brian Schaffhausen
Tyrosine phosphorylation is a signal for the trafficking of pp85, an 85-kDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4458-62.
1989: D R Kaplan; David C Pallas; W Morgan; Brian Schaffhausen; Thomas M Roberts
Mechanisms of transformation by polyoma virus middle T antigen.
Biochimica et biophysica acta 1989;948(3):345-64.
1988: David C Pallas; V Cherington; W Morgan; J DeAnda; D Kaplan; Brian Schaffhausen; Thomas M Roberts
Cellular proteins that associate with the middle and small T antigens of polyomavirus.
Journal of virology 1988;62(11):3934-40.
1988: T Ramqvist; David C Pallas; J DeAnda; Lars Ahrlund-Richter; G Reinholdsson; Thomas M Roberts; Brian Schaffhausen; T Dalianis
Immunization against the polyoma tumor-specific transplantation antigen (TSTA) with polyoma T-antigens.
International journal of cancer. Journal international du cancer 1988;42(1):123-8.
1988: Thomas M Roberts; D Kaplan; W Morgan; T Keller; Harvey J Mamon; Helen Piwnica-Worms; Brian J Druker; B Cohen; Brian Schaffhausen; Malcolm Whitman
Tyrosine phosphorylation in signal transduction.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():161-71.
1987: D R Kaplan; Malcolm Whitman; Brian Schaffhausen; David C Pallas; M White; L Cantley; Thomas M Roberts
Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity.
Cell 1987;50(7):1021-9.
1987: K L Berkner; Brian Schaffhausen; Thomas M Roberts; Phillip A Sharp
Abundant expression of polyomavirus middle T antigen and dihydrofolate reductase in an adenovirus recombinant.
Journal of virology 1987;61(4):1213-20.
1987: B J Bockus; Brian Schaffhausen
Localization of the phosphorylations of polyomavirus large T antigen.
Journal of virology 1987;61(4):1155-63.
1987: B J Bockus; Brian Schaffhausen
Phosphorylation of polyomavirus large T antigen: effects of viral mutations and cell growth state.
Journal of virology 1987;61(4):1147-54.
1987: Brian Schaffhausen; B J Bockus; K L Berkner; D Kaplan; Thomas M Roberts
Characterization of middle T antigen expressed by using an adenovirus expression system.
Journal of virology 1987;61(4):1221-5.
1986: David C Pallas; C Schley; M Mahoney; Ed Harlow; Brian Schaffhausen; Thomas M Roberts
Polyomavirus small t antigen: overproduction in bacteria, purification, and utilization for monoclonal and polyclonal antibody production.
Journal of virology 1986;60(3):1075-84.
1986: Malcolm Whitman; D Kaplan; L Cantley; Thomas M Roberts; Brian Schaffhausen
Phosphoinositide kinase activity and transformation.
Federation proceedings 1986;45(11):2647-52.
1986: D R Kaplan; Malcolm Whitman; Brian Schaffhausen; L Raptis; R L Garcea; David C Pallas; Thomas M Roberts; L Cantley
Phosphatidylinositol metabolism and polyoma-mediated transformation.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(11):3624-8.
1986: L Cantley; Malcolm Whitman; D R Kaplan; S B Chahwala; L Fleischman; G Endemann; Brian Schaffhausen; Thomas M Roberts
Phosphatidylinositol kinases and cell transformation.
Symposium on Fundamental Cancer Research 1986;39():165-72.
1986: L C Cantley; Malcolm Whitman; S Chahwala; L Fleischman; D R Kaplan; Brian Schaffhausen; Thomas M Roberts
Oncogenes and phosphatidylinositol turnover.
Annals of the New York Academy of Sciences 1986;488():481-90.
1985: Brian Schaffhausen; T J Liang; G G Carmichael; T L Benjamin
Residual transforming activity of PY1178T, a mutant lacking the principal in vitro tyrosine phosphorylation site, is not affected by removal of the secondary tyrosine phosphorylation site at residue 322.
Virology 1985;143(2):671-5.
1985: Malcolm Whitman; D R Kaplan; Brian Schaffhausen; L Cantley; Thomas M Roberts
Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation.
Nature 1985;315(6016):239-42.
1985: Brian Schaffhausen; T L Benjamin; J Lodge; D Kaplan; Thomas M Roberts
Expression of polyoma early gene products in E. coli.
Nucleic acids research 1985;13(2):501-19.
1984: G Carmichael; Brian Schaffhausen; Gail Mandel; TSANYANG LIANG; T L Benjamin
Transformation by polyoma virus is drastically reduced by substitution of phenylalanine for tyrosine at residue 315 of middle-sized tumor antigen.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(3):679-83.
1983: Thomas M Roberts; Brian Schaffhausen; T L Benjamin; I Bikel; J Lodge; D Kaplan
Expression of SV40 and polyoma T antigens in E. coli.
Gene amplification and analysis 1983;3():135-46.
1982: Brian Schaffhausen; T L Benjamin; L Pike; J Casnellie; E Krebs
Antibody to the nonapeptide Glu-Glu-Glu-Glu-Tyr-Met-Pro-Met-Glu is specific for polyoma middle T antigen and inhibits in vitro kinase activity.
The Journal of biological chemistry 1982;257(21):12467-70.
1982: Brian Schaffhausen; H Dorai; G Arakere; T L Benjamin
Polyoma virus middle T antigen: relationship to cell membranes and apparent lack of ATP-binding activity.
Molecular and cellular biology 1982;2(10):1187-98.
1982: G G Carmichael; Brian Schaffhausen; D I Dorsky; D B Oliver; T L Benjamin
Carboxy terminus of polyoma middle-sized tumor antigen is required for attachment to membranes, associated protein kinase activities, and cell transformation.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(11):3579-83.
1981: Brian Schaffhausen; T L Benjamin
Comparison of phosphorylation of two polyoma virus middle T antigens in vivo and in vitro.
Journal of virology 1981;40(1):184-96.
1980: T L Benjamin; G G Carmichael; Brian Schaffhausen
The hr-t gene of polyoma virus.
Cold Spring Harbor symposia on quantitative biology 1980;44 Pt 1,():263-70.