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Walter Schaffner

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TOP 3
Lilit Atanesyan; Susan E Celniker; Oleg Georgiev; Viola Günther; Walter Schaffner
Characterization of MtnE, the fifth metallothionein member in Drosophila.
Haiqing Hua; Gerd Multhaup; Lisa Münter; Oleg Georgiev; Anja Harmeier; Walter Schaffner
Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability.
Haiqing Hua; Viola Günther; Oleg Georgiev; Walter Schaffner
Distorted copper homeostasis with decreased sensitivity to cisplatin upon chaperone Atox1 deletion in Drosophila.

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All Publications

2011: Lilit Atanesyan; Susan E Celniker; Oleg Georgiev; Viola Günther; Walter Schaffner
Characterization of MtnE, the fifth metallothionein member in Drosophila.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2011;16(7):1047-56.
2011: Haiqing Hua; Gerd Multhaup; Lisa Münter; Oleg Georgiev; Anja Harmeier; Walter Schaffner
Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability.
Biological chemistry 2011;392(10):919-26.
2011: Haiqing Hua; Viola Günther; Oleg Georgiev; Walter Schaffner
Distorted copper homeostasis with decreased sensitivity to cisplatin upon chaperone Atox1 deletion in Drosophila.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2011;24(3):445-53.
2011: Nidhi Saini; Oleg Georgiev; Walter Schaffner
The parkin mutant phenotype in the fly is largely rescued by metal-responsive transcription factor (MTF-1).
Molecular and cellular biology 2011;31(10):2151-61.
2010: Nidhi Saini; Sandra Oelhafen; Haiqing Hua; Oleg Georgiev; Walter Schaffner; Hansruedi Büeler
Extended lifespan of Drosophila parkin mutants through sequestration of redox-active metals and enhancement of anti-oxidative pathways.
Neurobiology of disease 2010;40(1):82-92.
2010: Dominik Steiger; Michael Fetchko; Alla Vardanyan; Lilit Atanesyan; Kurt Steiner; Michelle L Turski; Dennis J Thiele; Oleg Georgiev; Walter Schaffner
The Drosophila copper transporter Ctr1C functions in male fertility.
The Journal of biological chemistry 2010;285(22):17089-97.
2010: Nidhi Saini; Walter Schaffner
Zinc supplement greatly improves the condition of parkin mutant Drosophila.
Biological chemistry 2010;391(5):513-8.
2010: Haiqing Hua; Oleg Georgiev; Walter Schaffner; Dominik Steiger
Human copper transporter Ctr1 is functional in Drosophila, revealing a high degree of conservation between mammals and insects.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2010;15(1):107-13.
2009: Uschi Lindert; Mirjam Cramer; Michael Meuli; Oleg Georgiev; Walter Schaffner
Metal-responsive transcription factor 1 (MTF-1) activity is regulated by a nonconventional nuclear localization signal and a metal-responsive transactivation domain.
Molecular and cellular biology 2009;29(23):6283-93.
2009: Kuppusamy Balamurugan; Haiqing Hua; Oleg Georgiev; Walter Schaffner
Mercury and cadmium trigger expression of the copper importer Ctr1B, which enables Drosophila to thrive on heavy metal-loaded food.
Biological chemistry 2009;390(2):109-13.
2008: Michael Kappeler; Elisabeth Kranz; Katrina Woolcock; Oleg Georgiev; Walter Schaffner
Drosophila bloom helicase maintains genome integrity by inhibiting recombination between divergent DNA sequences.
Nucleic acids research 2008;36(21):6907-17.
2008: Uschi Lindert; Lucas Leuzinger; Kurt Steiner; Oleg Georgiev; Walter Schaffner
Characterization of metal-responsive transcription factor (MTF-1) from the giant rodent capybara reveals features in common with human as well as with small rodents (mouse, rat). Short communication.
Chemistry & biodiversity 2008;5(8):1485-94.
2008: Xiaohua Chen; Haiqing Hua; Kuppusamy Balamurugan; Xiangming Kong; Limei Zhang; Graham Neil George; Oleg Georgiev; Walter Schaffner; David P Giedroc
Copper sensing function of Drosophila metal-responsive transcription factor-1 is mediated by a tetranuclear Cu(I) cluster.
Nucleic acids research 2008;36(9):3128-38.
2008: Alla Vardanyan; Lilit Atanesyan; Dieter Egli; Sunil Jayaramaiah Raja; Monica Steinmann-Zwicky; Renate Renkawitz-Pohl; Oleg Georgiev; Walter Schaffner
Dumpy-30 family members as determinants of male fertility and interaction partners of metal-responsive transcription factor 1 (MTF-1) in Drosophila.
BMC developmental biology 2008;8():68.
2007: Hajime Takeuchi; Oleg Georgiev; Michael Fetchko; Michael Kappeler; Walter Schaffner; Dieter Egli
In vivo construction of transgenes in Drosophila.
Genetics 2007;175(4):2019-28.
2007: Kuppusamy Balamurugan; Dieter Egli; Haiqing Hua; Rama Rajaram; Gerhard Seisenbacher; Oleg Georgiev; Walter Schaffner
Copper homeostasis in Drosophila by complex interplay of import, storage and behavioral avoidance.
The EMBO journal 2007;26(4):1035-44.
2006: Kuppusamy Balamurugan; Walter Schaffner
Copper homeostasis in eukaryotes: teetering on a tightrope.
Biochimica et biophysica acta 2006;1763(7):737-46.
2006: Dieter Egli; jordi domenech; Anand Selvaraj; Kuppusamy Balamurugan; Haiqing Hua; Mercè Capdevila; Oleg Georgiev; Walter Schaffner; Sílvia Atrian
The four members of the Drosophila metallothionein family exhibit distinct yet overlapping roles in heavy metal homeostasis and detoxification.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(6):647-58.
2006: Dieter Egli; Hasmik Yepiskoposyan; Anand Selvaraj; Kuppusamy Balamurugan; Rama Rajaram; Andreas Simons; Gerd Multhaup; Simone Mettler; Alla Vardanyan; Oleg Georgiev; Walter Schaffner
A family knockout of all four Drosophila metallothioneins reveals a central role in copper homeostasis and detoxification.
Molecular and cellular biology 2006;26(6):2286-96.
2006: Hasmik Yepiskoposyan; Dieter Egli; Tim Fergestad; Anand Selvaraj; Carina Treiber; Gerd Multhaup; Oleg Georgiev; Walter Schaffner
Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc.
Nucleic acids research 2006;34(17):4866-77.
2005: Dominique Sirena; Zsolt Ruzsics; Walter Schaffner; Urs F Greber; Silvio Hemmi
The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3.
Virology 2005;343(2):283-98.
2005: Mirjam Cramer; Ivana Nagy; Brian J Murphy; Max Gassmann; Michael Hottiger; Oleg Georgiev; Walter Schaffner
NF-kappaB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells.
Biological chemistry 2005;386(9):865-72.
2005: Christoph Fleischli; Sandra Verhaagh; Menzo J E Havenga; Dominique Sirena; Walter Schaffner; Roberto Cattaneo; Urs F Greber; Silvio Hemmi
The distal short consensus repeats 1 and 2 of the membrane cofactor protein CD46 and their distance from the cell membrane determine productive entry of species B adenovirus serotype 35.
Journal of virology 2005;79(15):10013-22.
2005: Anand Selvaraj; Kuppusamy Balamurugan; Hasmik Yepiskoposyan; Hao Zhou; Dieter Egli; Oleg Georgiev; Dennis J Thiele; Walter Schaffner
Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes.
Genes & development 2005;19(8):891-6.
2005: Ursula Wimmer; Ying Wang; Oleg Georgiev; Walter Schaffner
Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione.
Nucleic acids research 2005;33(18):5715-27.
2005: Michael Petrascheck; Dominik Escher; Tokameh Mahmoudi; C Peter Verrijzer; Walter Schaffner; Alcide Barberis
DNA looping induced by a transcriptional enhancer in vivo.
Nucleic acids research 2005;33(12):3743-50.
2004: Zishan A Haroon; Khalid Amin; Peter Lichtlen; Barbara G Sato; Nhung T Huynh; Zhaohui Wang; Walter Schaffner; Brian J Murphy
Loss of metal transcription factor-1 suppresses tumor growth through enhanced matrix deposition.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(11):1176-84.
2004: Ying Wang; Iris Lorenzi; Oleg Georgiev; Walter Schaffner
Metal-responsive transcription factor-1 (MTF-1) selects different types of metal response elements at low vs. high zinc concentration.
Biological chemistry 2004;385(7):623-32.
2004: Kuppusamy Balamurugan; Dieter Egli; Anand Selvaraj; Bo Zhang; Oleg Georgiev; Walter Schaffner
Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison.
Biological chemistry 2004;385(7):597-603.
2004: Ying Wang; Ursula Wimmer; Peter Lichtlen; Daniel Inderbitzin; Bruno Stieger; Peter J Meier Abt; Lukas Hunziker; Thomas Stallmach; Rhea Forrer; Thomas Rülicke; Oleg Georgiev; Walter Schaffner
Metal-responsive transcription factor-1 (MTF-1) is essential for embryonic liver development and heavy metal detoxification in the adult liver.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(10):1071-9.
2004: Dieter Egli; Ernst Hafen; Walter Schaffner
An efficient method to generate chromosomal rearrangements by targeted DNA double-strand breaks in Drosophila melanogaster.
Genome research 2004;14(7):1382-93.
2003: Bo Zhang; Oleg Georgiev; Michael Hagmann; Cagatay Günes; Mirjam Cramer; Peter Faller; Milan Vasák; Walter Schaffner
Activity of metal-responsive transcription factor 1 by toxic heavy metals and H2O2 in vitro is modulated by metallothionein.
Molecular and cellular biology 2003;23(23):8471-85.
2003: Nurten Saydam; Florian Steiner; Oleg Georgiev; Walter Schaffner
Heat and heavy metal stress synergize to mediate transcriptional hyperactivation by metal-responsive transcription factor MTF-1.
The Journal of biological chemistry 2003;278(34):31879-83.
2003: Isabelle Peter; C Graf; Reinhard Dummer; Walter Schaffner; Urs F Greber; Silvio Hemmi
A novel attenuated replication-competent adenovirus for melanoma therapy.
Gene therapy 2003;10(7):530-9.
2003: Dieter Egli; Anand Selvaraj; Hasmik Yepiskoposyan; Bo Zhang; Ernst Hafen; Oleg Georgiev; Walter Schaffner
Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis.
The EMBO journal 2003;22(1):100-8.
2002: Timothy K Adams; Nurten Saydam; Florian Steiner; Walter Schaffner; Jonathan H Freedman
Activation of gene expression by metal-responsive signal transduction pathways.
Environmental health perspectives 2002;110 Suppl 5():813-7.
2002: Nurten Saydam; Timothy K Adams; Florian Steiner; Walter Schaffner; Jonathan H Freedman
Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription.
The Journal of biological chemistry 2002;277(23):20438-45.
2001: Peter Lichtlen; Walter Schaffner
The "metal transcription factor" MTF-1: biological facts and medical implications.
Swiss medical weekly 2001;131(45-46):647-52.
2001: Peter Lichtlen; Walter Schaffner
Putting its fingers on stressful situations: the heavy metal-regulatory transcription factor MTF-1.
BioEssays : news and reviews in molecular, cellular and developmental biology 2001;23(11):1010-7.
2001: Nurten Saydam; Oleg Georgiev; M Y Nakano; Urs F Greber; Walter Schaffner
Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals.
The Journal of biological chemistry 2001;276(27):25487-95.
2001: Bo Zhang; Dieter Egli; Oleg Georgiev; Walter Schaffner
The Drosophila homolog of mammalian zinc finger factor MTF-1 activates transcription in response to heavy metals.
Molecular and cellular biology 2001;21(14):4505-14.
2001: Peter Lichtlen; Ying Wang; T Belser; Oleg Georgiev; Ulrich Certa; Ragna Sack; Walter Schaffner
Target gene search for the metal-responsive transcription factor MTF-1.
Nucleic acids research 2001;29(7):1514-23.
2001: C J Green; Peter Lichtlen; N T Huynh; M Yanovsky; Keith R Laderoute; Walter Schaffner; Brian J Murphy
Placenta growth factor gene expression is induced by hypoxia in fibroblasts: a central role for metal transcription factor-1.
Cancer research 2001;61(6):2696-703.
2000: Adrian Auf der Maur; T Belser; Ying Wang; Cagatay Günes; Peter Lichtlen; Oleg Georgiev; Walter Schaffner
Characterization of the mouse gene for the heavy metal-responsive transcription factor MTF-1.
Cell stress & chaperones 2000;5(3):196-206.
2000: Dominik Escher; M Bodmer-Glavas; Alcide Barberis; Walter Schaffner
Conservation of glutamine-rich transactivation function between yeast and humans.
Molecular and cellular biology 2000;20(8):2774-82.
1999: Peter Lichtlen; Oleg Georgiev; Walter Schaffner; Adriano Aguzzi; Sebastian Brandner
The heavy metal-responsive transcription factor-1 (MTF-1) is not required for neural differentiation.
Biological chemistry 1999;380(6):711-5.
1999: Adrian Auf der Maur; T Belser; greg elgar; Oleg Georgiev; Walter Schaffner
Characterization of the transcription factor MTF-1 from the Japanese pufferfish (Fugu rubripes) reveals evolutionary conservation of heavy metal stress response.
Biological chemistry 1999;380(2):175-85.
1998: Michael Hagmann; Rémy Bruggmann; L Xue; Oleg Georgiev; Walter Schaffner; Duri Rungger; P Spaniol; T Gerster
Homologous recombination and DNA-end joining reactions in zygotes and early embryos of zebrafish (Danio rerio) and Drosophila melanogaster.
Biological chemistry 1998;379(6):673-81.
1998: Cagatay Günes; R Heuchel; Oleg Georgiev; K H Müller; Peter Lichtlen; H Blüthmann; Silvia Marino; Adriano Aguzzi; Walter Schaffner
Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1.
The EMBO journal 1998;17(10):2846-54.
1998: Walter Schaffner
EMBO workshop on "gene expression under stress conditions" in Carcavelos-Lisbon, Portugal.
Biological chemistry 1998;379(1):87-92.
1997: K I Rother; O K Clay; Jean-Pierre Bourquin; J Silke; Walter Schaffner
Long non-stop reading frames on the antisense strand of heat shock protein 70 genes and prion protein (PrP) genes are conserved between species.
Biological chemistry 1997;378(12):1521-30.
1997: Dominik Escher; Walter Schaffner
Gene activation at a distance and telomeric silencing are not affected by yeast histone H1.
Molecular & general genetics : MGG 1997;256(4):456-61.
1997: Michael Hagmann; Oleg Georgiev; Walter Schaffner
The VP16 paradox: herpes simplex virus VP16 contains a long-range activation domain but within the natural multiprotein complex activates only from promoter-proximal positions.
Journal of virology 1997;71(8):5952-62.
1997: P Moosmann; Oleg Georgiev; H J Thiesen; Michael Hagmann; Walter Schaffner
Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Krüppel-type zinc finger factor.
Biological chemistry 1997;378(7):669-77.
1997: S Tanner; Igor Stagljar; Oleg Georgiev; Walter Schaffner; Jean-Pierre Bourquin
A novel SR-related protein specifically interacts with the carboxy-terminal domain (CTD) of RNA polymerase II through a conserved interaction domain.
Biological chemistry 1997;378(6):565-71.
1997: Jean-Pierre Bourquin; Igor Stagljar; P Meier; P Moosmann; J Silke; Thomas Baechi; Oleg Georgiev; Walter Schaffner
A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase II.
Nucleic acids research 1997;25(11):2055-61.
1996: P Moosmann; Oleg Georgiev; B Le Douarin; Jean-Pierre Bourquin; Walter Schaffner
Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1.
Nucleic acids research 1996;24(24):4859-67.
1996: D Escher; Walter Schaffner
Improved "activator trap" method for the isolation of transcriptional activation domains from random DNA fragments.
BioTechniques 1996;21(5):848-54.
1996: Matthias Gstaiger; Christopher M Hovens; Oleg Georgiev; L Knoepfel; Walter Schaffner
BZLF1 (ZEBRA, Zta) protein of Epstein-Barr virus selected in a yeast one-hybrid system by binding to a consensus site in the IgH intronic enhancer: a role in immunoglobulin expression?
Biological chemistry 1996;377(10):669-73.
1996: Matthias Gstaiger; Oleg Georgiev; Walter Schaffner
Fine mapping of protein interaction surfaces with a PCR-based mutagenesis screen in yeast.
Trends in genetics : TIG 1996;12(10):393-4.
1996: Igor Stagljar; Jean-Pierre Bourquin; Walter Schaffner
Use of the two-hybrid system and random sonicated DNA to identify the interaction domain of a protein.
BioTechniques 1996;21(3):430-2.
1996: Matthias Gstaiger; Oleg Georgiev; H van Leeuwen; P van der Vliet; Walter Schaffner
The B cell coactivator Bob1 shows DNA sequence-dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation.
The EMBO journal 1996;15(11):2781-90.
1996: Michael Hagmann; K Adlkofer; P Pfeiffer; R Bruggmann; Oleg Georgiev; Duri Rungger; Walter Schaffner
Dramatic changes in the ratio of homologous recombination to nonhomologous DNA-end joining in oocytes and early embryos of Xenopus laevis.
Biological chemistry Hoppe-Seyler 1996;377(4):239-50.
1996: Oleg Georgiev; Jean-Pierre Bourquin; Matthias Gstaiger; L Knoepfel; Walter Schaffner; Christopher M Hovens
Two versatile eukaryotic vectors permitting epitope tagging, radiolabelling and nuclear localisation of expressed proteins.
Gene 1996;168(2):165-7.
1996: M Hug; J Silke; Oleg Georgiev; S Rusconi; Walter Schaffner; Koichi Matsuo
Transcriptional repression by methylation: cooperativity between a CpG cluster in the promoter and remote CpG-rich regions.
FEBS letters 1996;379(3):251-4.
1996: L Knoepfel; Oleg Georgiev; P Nielsen; Walter Schaffner
Cloning and characterization of the murine B-cell specific transcriptional coactivator Bob1.
Biological chemistry Hoppe-Seyler 1996;377(2):139-45.
1996: Freddy Radtke; M Hug; Oleg Georgiev; Koichi Matsuo; Walter Schaffner
Differential sensitivity of zinc finger transcription factors MTF-1, Sp1 and Krox-20 to CpG methylation of their binding sites.
Biological chemistry Hoppe-Seyler 1996;377(1):47-56.
1995: Michael Hagmann; Oleg Georgiev; Walter Schaffner; P Douville
Transcription factors interacting with herpes simplex virus alpha gene promoters in sensory neurons.
Nucleic acids research 1995;23(24):4978-85.
1995: K I Rother; J Silke; Oleg Georgiev; Walter Schaffner; Koichi Matsuo
Influence of DNA sequence and methylation status on bisulfite conversion of cytosine residues.
Analytical biochemistry 1995;231(1):263-5.
1995: H P Müller; E Brungnera; Oleg Georgiev; M Badzong; K H Müller; Walter Schaffner
Analysis of the heavy metal-responsive transcription factor MTF-1 from human and mouse.
Somatic cell and molecular genetics 1995;21(5):289-97.
1995: J Silke; K I Rother; Oleg Georgiev; Walter Schaffner; Koichi Matsuo
Complex demethylation patterns at Sp1 binding sites in F9 embryonal carcinoma cells.
FEBS letters 1995;370(3):170-4.
1995: Freddy Radtke; Oleg Georgiev; H P Müller; E Brugnera; Walter Schaffner
Functional domains of the heavy metal-responsive transcription regulator MTF-1.
Nucleic acids research 1995;23(12):2277-86.
1995: K Gramatikoff; Walter Schaffner; Oleg Georgiev
The leucine zipper of c-Jun binds to ribosomal protein L18a: a role in Jun protein regulation?
Biological chemistry Hoppe-Seyler 1995;376(5):321-5.
1995: H P Gerber; Michael Hagmann; K Seipel; Oleg Georgiev; M A West; Ying Litingtung; Walter Schaffner; Jeffry L Corden
RNA polymerase II C-terminal domain required for enhancer-driven transcription.
Nature 1995;374(6523):660-2.
1995: P Künzler; Koichi Matsuo; Walter Schaffner
Pathological, physiological, and evolutionary aspects of short unstable DNA repeats in the human genome.
Biological chemistry Hoppe-Seyler 1995;376(4):201-11.
1995: M Hottiger; K Gramatikoff; Oleg Georgiev; C Chaponnier; Walter Schaffner; Ulrich Hübscher
The large subunit of HIV-1 reverse transcriptase interacts with beta-actin.
Nucleic acids research 1995;23(5):736-41.
1995: M Hergersberg; Koichi Matsuo; M Gassmann; Walter Schaffner; Bernhard Lüscher; Thomas Rülicke; Adriano Aguzzi
Tissue-specific expression of a FMR1/beta-galactosidase fusion gene in transgenic mice.
Human molecular genetics 1995;4(3):359-66.
1995: O Clay; Walter Schaffner; Koichi Matsuo
Periodicity of eight nucleotides in purine distribution around human genomic CpG dinucleotides.
Somatic cell and molecular genetics 1995;21(2):91-8.
1995: P Douville; Michael Hagmann; Oleg Georgiev; Walter Schaffner
Positive and negative regulation at the herpes simplex virus ICP4 and ICP0 TAATGARAT motifs.
Virology 1995;207(1):107-16.
1995: Matthias Gstaiger; L Knoepfel; Oleg Georgiev; Walter Schaffner; Christopher M Hovens
A B-cell coactivator of octamer-binding transcription factors.
Nature 1995;373(6512):360-2.
1994: K Gramatikoff; Oleg Georgiev; Walter Schaffner
Direct interaction rescue, a novel filamentous phage technique to study protein-protein interactions.
Nucleic acids research 1994;22(25):5761-2.
1994: Koichi Matsuo; J Silke; K Gramatikoff; Walter Schaffner
The CpG-specific methylase SssI has topoisomerase activity in the presence of Mg2+.
Nucleic acids research 1994;22(24):5354-9.
1994: I Pult; A Sajantila; J Simanainen; Oleg Georgiev; Walter Schaffner; S Pääbo
Mitochondrial DNA sequences from Switzerland reveal striking homogeneity of European populations.
Biological chemistry Hoppe-Seyler 1994;375(12):837-40.
1994: Matthias Gstaiger; Walter Schaffner
Strong transcriptional activators isolated from viral DNA by the 'activator trap', a novel selection system in mammalian cells.
Nucleic acids research 1994;22(20):4031-8.
1994: Koichi Matsuo; O Clay; P Künzler; Oleg Georgiev; P Urbánek; Walter Schaffner
Short introns interrupting the Oct-2 POU domain may prevent recombination between POU family genes without interfering with potential POU domain 'shuffling' in evolution.
Biological chemistry Hoppe-Seyler 1994;375(10):675-83.
1994: K Seipel; Oleg Georgiev; H P Gerber; Walter Schaffner
Basal components of the transcription apparatus (RNA polymerase II, TATA-binding protein) contain activation domains: is the repetitive C-terminal domain (CTD) of RNA polymerase II a "portable enhancer domain"?
Molecular reproduction and development 1994;39(2):215-25.
1994: E Brugnera; Oleg Georgiev; Freddy Radtke; R Heuchel; E Baker; G R Sutherland; Walter Schaffner
Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1.
Nucleic acids research 1994;22(15):3167-73.
1994: K Seipel; Oleg Georgiev; Walter Schaffner
A minimal transcription activation domain consisting of a specific array of aspartic acid and leucine residues.
Biological chemistry Hoppe-Seyler 1994;375(7):463-70.
1994: R Heuchel; Freddy Radtke; Oleg Georgiev; G Stark; M Aguet; Walter Schaffner
The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression.
The EMBO journal 1994;13(12):2870-5.
1994: H P Gerber; K Seipel; Oleg Georgiev; M Höfferer; M Hug; S Rusconi; Walter Schaffner
Transcriptional activation modulated by homopolymeric glutamine and proline stretches.
Science (New York, N.Y.) 1994;263(5148):808-11.
1994: M Künzler; Gerhard H Braus; Oleg Georgiev; K Seipel; Walter Schaffner
Functional differences between mammalian transcription activation domains at the yeast GAL1 promoter.
The EMBO journal 1994;13(3):641-5.
1994: L Xu; Duri Rungger; Oleg Georgiev; K Seipel; Walter Schaffner
Different potential of cellular and viral activators of transcription revealed in oocytes and early embryos of Xenopus laevis.
Biological chemistry Hoppe-Seyler 1994;375(2):105-12.
1993: K Seipel; Oleg Georgiev; H P Gerber; Walter Schaffner
C-terminal domain (CTD) of RNA-polymerase II and N-terminal segment of the human TATA binding protein (TBP) can mediate remote and proximal transcriptional activation, respectively.
Nucleic acids research 1993;21(24):5609-15.
1993: David N Arnosti; Chris M Preston; Michael Hagmann; Walter Schaffner; R G Hope; G Laughlan; Ben F Luisi
Specific transcriptional activation in vitro by the herpes simplex virus protein VP16.
Nucleic acids research 1993;21(24):5570-6.
1993: Koichi Matsuo; O Clay; T Takahashi; J Silke; Walter Schaffner
Evidence for erosion of mouse CpG islands during mammalian evolution.
Somatic cell and molecular genetics 1993;19(6):543-55.
1993: L Xu; Walter Schaffner; Duri Rungger
Transcriptional activation by recombinant GAL4-VP16 in the Xenopus oocyte.
Nucleic acids research 1993;21(11):2775.
1993: P Rigoni; L Xu; K Harshman; Walter Schaffner; David N Arnosti
Conserved cysteine residues of Oct-2 POU domain confer sensitivity to oxidation but are dispensable for sequence-specific DNA binding.
Biochimica et biophysica acta 1993;1173(2):141-6.
1993: Freddy Radtke; R Heuchel; Oleg Georgiev; M Hergersberg; M Gariglio; Z Dembic; Walter Schaffner
Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter.
The EMBO journal 1993;12(4):1355-62.
1993: E Schreiber; A Tobler; Ursula Malipiero; Walter Schaffner; Adriano Fontana
cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif.
Nucleic acids research 1993;21(2):253-8.
1993: David N Arnosti; A Merino; D Reinberg; Walter Schaffner
Oct-2 facilitates functional preinitiation complex assembly and is continuously required at the promoter for multiple rounds of transcription.
The EMBO journal 1993;12(1):157-66.
1992: E Brugnera; L Xu; Walter Schaffner; David N Arnosti
POU-specific domain of Oct-2 factor confers 'octamer' motif DNA binding specificity on heterologous Antennapedia homeodomain.
FEBS letters 1992;314(3):361-5.
1992: K Seipel; Oleg Georgiev; Walter Schaffner
Different activation domains stimulate transcription from remote ('enhancer') and proximal ('promoter') positions.
The EMBO journal 1992;11(13):4961-8.
1992: H P Gerber; Oleg Georgiev; K Harshman; Walter Schaffner
In vitro transcription complementation assay with miniextracts of transiently transfected COS-1 cells.
Nucleic acids research 1992;20(21):5855-6.
1991: A Czank; R Häuselmann; A W Page; H Leonhardt; Timothy H Bestor; Walter Schaffner; M Hergersberg
Expression in mammalian cells of a cloned gene encoding murine DNA methyltransferase.
Gene 1991;109(2):259-63.
1991: L C Xu; M Thali; Walter Schaffner
Upstream box/TATA box order is the major determinant of the direction of transcription.
Nucleic acids research 1991;19(24):6699-704.
1991: J Yang; M M Müller-Immerglück; K Seipel; L Janson; Gunnar Westin; Walter Schaffner; Ulf Pettersson
Both Oct-1 and Oct-2A contain domains which can activate the ubiquitously expressed U2 snRNA genes.
The EMBO journal 1991;10(8):2291-6.
1991: M Kermekchiev; M Pettersson; Patrick Matthias; Walter Schaffner
Every enhancer works with every promoter for all the combinations tested: could new regulatory pathways evolve by enhancer shuffling?
Gene expression 1991;1(1):71-81.
1991: J Zeng; R Heuchel; Walter Schaffner; JH Kägi
Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Sp1.
FEBS letters 1991;279(2):310-2.
1991: I Kemler; Etienne Bucher; K Seipel; M M Müller-Immerglück; Walter Schaffner
Promoters with the octamer DNA motif (ATGCAAAT) can be ubiquitous or cell type-specific depending on binding affinity of the octamer site and Oct-factor concentration.
Nucleic acids research 1991;19(2):237-42.
1990: E Schreiber; K Harshman; I Kemler; Ursula Malipiero; Walter Schaffner; Adriano Fontana
Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins.
Nucleic acids research 1990;18(18):5495-503.
1990: M Thali; S Rusconi; Walter Schaffner
Immediate early protein of pseudorabies virus is a general transactivator but stimulates only suboptimally utilized promoters. A clue to specificity?
Journal of molecular biology 1990;215(2):301-11.
1990: H P Müller; Walter Schaffner
Transcriptional enhancers can act in trans.
Trends in genetics : TIG 1990;6(9):300-4.
1990: M Pettersson; Walter Schaffner
Synergistic activation of transcription by multiple binding sites for NF-kappa B even in absence of co-operative factor binding to DNA.
Journal of molecular biology 1990;214(2):373-80.
1990: H P Müller; Patrick Matthias; Walter Schaffner
A transcriptional terminator between enhancer and promoter does not affect remote transcriptional control.
Somatic cell and molecular genetics 1990;16(4):351-60.
1990: M M Müller-Immerglück; Walter Schaffner; Patrick Matthias
Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells.
The EMBO journal 1990;9(5):1625-34.
1990: I Kemler; Walter Schaffner
Octamer transcription factors and the cell type-specificity of immunoglobulin gene expression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1990;4(5):1444-9.
1990: N Elmaleh; Patrick Matthias; Walter Schaffner
A factor known to bind to endogenous Ig heavy chain enhancer only in lymphocytes is a ubiquitously active transcription factor.
European journal of biochemistry / FEBS 1990;187(3):507-13.
1990: M D Schatt; S Rusconi; Walter Schaffner
A single DNA-binding transcription factor is sufficient for activation from a distant enhancer and/or from a promoter position.
The EMBO journal 1990;9(2):481-7.
1989: R Heuchel; Patrick Matthias; Walter Schaffner
Two closely spaced promoters are equally activated by a remote enhancer: evidence against a scanning model for enhancer action.
Nucleic acids research 1989;17(22):8931-47.
1989: E Schreiber; Walter Schaffner
Long-range activation of transcription by SV40 enhancer is affected by "inhibitory" or "permissive" DNA sequences between enhancer and promoter.
Somatic cell and molecular genetics 1989;15(6):591-603.
1989: H P Müeller-Storm; J M Sogo; Walter Schaffner
An enhancer stimulates transcription in trans when attached to the promoter via a protein bridge.
Cell 1989;58(4):767-77.
1989: M M Müller; E Schreiber; Walter Schaffner; Patrick Matthias
Rapid test for in vivo stability and DNA binding of mutated octamer binding proteins with 'mini-extracts' prepared from transfected cells.
Nucleic acids research 1989;17(15):6420.
1989: E Schreiber; Patrick Matthias; M M Müller; Walter Schaffner
Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells.
Nucleic acids research 1989;17(15):6419.
1989: Patrick Matthias; M M Müller; E Schreiber; S Rusconi; Walter Schaffner
Eukaryotic expression vectors for the analysis of mutant proteins.
Nucleic acids research 1989;17(15):6418.
1989: I Kemler; E Schreiber; M M Müller; Patrick Matthias; Walter Schaffner
Octamer transcription factors bind to two different sequence motifs of the immunoglobulin heavy chain promoter.
The EMBO journal 1989;8(7):2001-8.
1989: S M Iguchi-Ariga; Walter Schaffner
CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation.
Genes & development 1989;3(5):612-9.
1988: E Schreiber; Patrick Matthias; M M Müller; Walter Schaffner
Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA).
The EMBO journal 1988;7(13):4221-9.
1988: M M Müller; S Ruppert; Walter Schaffner; Patrick Matthias
A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells.
Nature 1988;336(6199):544-51.
1988: G Westin; Walter Schaffner
A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene.
The EMBO journal 1988;7(12):3763-70.
1988: M M Müller; T Gerster; Walter Schaffner
Enhancer sequences and the regulation of gene transcription.
European journal of biochemistry / FEBS 1988;176(3):485-95.
1988: M Höller; G Westin; J Jiricny; Walter Schaffner
Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated.
Genes & development 1988;2(9):1127-35.
1988: Y Severne; S Wieland; Walter Schaffner; S Rusconi
Metal binding 'finger' structures in the glucocorticoid receptor defined by site-directed mutagenesis.
The EMBO journal 1988;7(8):2503-8.
1988: G Westin; Walter Schaffner
Heavy metal ions in transcription factors from HeLa cells: Sp1, but not octamer transcription factor requires zinc for DNA binding and for activator function.
Nucleic acids research 1988;16(13):5771-81.
1988: G Schaffner; S Schirm; B Müller-Baden; F Weber; Walter Schaffner
Redundancy of information in enhancers as a principle of mammalian transcription control.
Journal of molecular biology 1988;201(1):81-90.
1987: M Petterson; Walter Schaffner
A purine-rich DNA sequence motif present in SV40 and lymphotropic papovavirus binds a lymphoid-specific factor and contributes to enhancer activity in lymphoid cells.
Genes & development 1987;1(9):962-72.
1987: G Westin; T Gerster; M M Müller; G Schaffner; Walter Schaffner
OVEC, a versatile system to study transcription in mammalian cells and cell-free extracts.
Nucleic acids research 1987;15(17):6787-98.
1987: T Gerster; Patrick Matthias; M Thali; J Jiricny; Walter Schaffner
Cell type-specificity elements of the immunoglobulin heavy chain gene enhancer.
The EMBO journal 1987;6(5):1323-30.
1987: S Schirm; J Jiricny; Walter Schaffner
The SV40 enhancer can be dissected into multiple segments, each with a different cell type specificity.
Genes & development 1987;1(1):65-74.
1987: E Serfling; Walter Schaffner
Inducible and constitutive sequence elements in the enhancer of the mouse metallothionein-I gene.
Experientia. Supplementum 1987;52():415-22.