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James Black

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Competitive Binding

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Muscle Contraction

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Co-Publications
Name
43
Shankley, Nigel
13
Harper, Elaine
5
Kalindjian, Barret
4
Hull, Robert
4
van Der Graaf, Piet
3
Steel, Katherine
3
Griffin, Eric
3
Pether, Michael
3
McDonald, Iain
3
Dunstone, David
3
Buck, Ildiko
3
Kenakin, Terry
2
Ganellin, Robin
2
Linney, Ian
2
Low, Caroline

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Publications

TOP 3
Black James W
Reflections on some pilot trials of gastrin receptor blockade in pancreatic cancer.
McDonald Iain M; Black James W; Buck Ildiko M; Dunstone David J; Griffin Eric P; Harper Elaine A; Hull Robert A D; Kalindjian S Barret; Lilley Elliot J; Linney Ian D; Pether Michael J; Roberts Sonia P; Shaxted Mark E; Spencer John; Steel Katherine I M; Sykes David A; Walker Martin K; Watt Gillian F; Wright Laurence; Wright Paul T; Xun Wei
Optimization of 1,3,4-benzotriazepine-based CCK(2) antagonists to obtain potent, orally active inhibitors of gastrin-mediated gastric acid secretion.
Harper E A; Black J W
Histamine H3-receptor agonists and imidazole-based H3-receptor antagonists can be thermodynamically discriminated.

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All Publications

2009: Black James W
Reflections on some pilot trials of gastrin receptor blockade in pancreatic cancer.
European journal of cancer (Oxford, England : 1990) 2009;45(3):360-4.
2007: McDonald Iain M; Black James W; Buck Ildiko M; Dunstone David J; Griffin Eric P; Harper Elaine A; Hull Robert A D; Kalindjian S Barret; Lilley Elliot J; Linney Ian D; Pether Michael J; Roberts Sonia P; Shaxted Mark E; Spencer John; Steel Katherine I M; Sykes David A; Walker Martin K; Watt Gillian F; Wright Laurence; Wright Paul T; Xun Wei
Optimization of 1,3,4-benzotriazepine-based CCK(2) antagonists to obtain potent, orally active inhibitors of gastrin-mediated gastric acid secretion.
Journal of medicinal chemistry 2007;50(13):3101-12.
2007: Harper E A; Black J W
Histamine H3-receptor agonists and imidazole-based H3-receptor antagonists can be thermodynamically discriminated.
British journal of pharmacology 2007;151(4):504-17.
2007: Harper E A; Shankley N P; Black J W
Correlation of apparent affinity values from H3-receptor binding assays with apparent affinity (pKapp) and intrinsic activity (alpha) from functional bioassays.
British journal of pharmacology 2007;151(1):128-43.
2007: Gerskowitch V P; Hodge J; Hull R A D; Shankley N P; Kalindjian S B; McEwen J; Black J W
Unexpected relationship between plasma protein binding and the pharmacodynamics of 2-NAP, a CCK1-receptor antagonist.
British journal of clinical pharmacology 2007;63(5):618-22.
2006: Chau I; Cunningham D; Russell C; Norman A R; Kurzawinski T; Harper P; Harrison P; Middleton G; Daniels F; Hickish T; Prendeville J; Ross P J; Theis B; Hull R; Walker M; Shankley N; Kalindjian B; Murray G; Gillbanks A; Black J
Gastrazole (JB95008), a novel CCK2/gastrin receptor antagonist, in the treatment of advanced pancreatic cancer: results from two randomised controlled trials.
British journal of cancer 2006;94(8):1107-15.
2005: Buck Ildiko M; Black James W; Cooke Tracey; Dunstone David J; Gaffen John D; Griffin Eric P; Harper Elaine A; Hull Robert A D; Kalindjian S Barret; Lilley Elliot J; Linney Ian D; Low Caroline M R; McDonald Iain M; Pether Michael J; Roberts Sonia P; Shankley Nigel P; Shaxted Mark E; Steel Katherine I M; Sykes David A; Tozer Matthew J; Watt Gillian F; Walker Martin K; Wright Laurence; Wright Paul T
Optimization of the in vitro and in vivo properties of a novel series of 2,4,5-trisubstituted imidazoles as potent cholecystokinin-2 (CCK2) antagonists.
Journal of medicinal chemistry 2005;48(22):6803-12.
2004: Black James
Drugs from emasculated hormones: the principle of syntopic antagonism.
Bioscience reports 2004;24(4-5):302-22.
2003: Hasseldine A R G; Harper E A; Black J W
Cardiac-specific overexpression of human beta2 adrenoceptors in mice exposes coupling to both Gs and Gi proteins.
British journal of pharmacology 2003;138(7):1358-66.
2002: Black James W; Kalindjian S Barret
Gastrin agonists and antagonists.
Pharmacology & toxicology 2002;91(6):275-81.
2001: Harper E A; Lovenberg T W; Shankley N P; Black J W
Comparison of ligand affinity values at the recombinant human H3 receptor and at H3 receptor(s) of human cingulate cortex.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2001;50 Suppl 2():S106-7.
2000: Low C M; Black J W; Broughton H B; Buck I M; Davies J M; Dunstone D J; Hull R A; Kalindjian S B; McDonald I M; Pether M J; Shankley N P; Steel K I
Development of peptide 3D structure mimetics: rational design of novel peptoid cholecystokinin receptor antagonists.
Journal of medicinal chemistry 2000;43(19):3505-17.
2000: Prendergast C E; Shankley N P; Black J W
Negative inotropic effects of isoprenaline on isolated left atrial assays from aged transgenic mice with cardiac over-expression of human beta(2)-adrenoceptors.
British journal of pharmacology 2000;129(7):1285-8.
1999: Harper E A; Shankley N P; Black J W
Characterization of the binding of [3H]-clobenpropit to histamine H3-receptors in guinea-pig cerebral cortex membranes.
British journal of pharmacology 1999;128(4):881-90.
1999: Harper E A; Shankley N P; Black J W
Evidence that histamine homologues discriminate between H3-receptors in guinea-pig cerebral cortex and ileum longitudinal muscle myenteric plexus.
British journal of pharmacology 1999;128(3):751-9.
1999: Harper E A; Shankley N P; Black J W
Characterization of the binding of a novel radioligand to CCKB/gastrin receptors in membranes from rat cerebral cortex.
British journal of pharmacology 1999;126(6):1504-12.
1999: Harper E A; Griffin E P; Shankley N P; Black J W
Analysis of the behaviour of selected CCKB/gastrin receptor antagonists in radioligand binding assays performed in mouse and rat cerebral cortex.
British journal of pharmacology 1999;126(6):1496-503.
1998: Meester B J; Shankley N P; Welsh N J; Meijler F L; Black J W
Pharmacological analysis of the activity of the adenosine uptake inhibitor, dipyridamole, on the sinoatrial and atrioventricular nodes of the guinea-pig.
British journal of pharmacology 1998;124(4):729-41.
1998: Meester B J; Shankley N P; Welsh N J; Wood J; Meijler F L; Black J W
Pharmacological classification of adenosine receptors in the sinoatrial and atrioventricular nodes of the guinea-pig.
British journal of pharmacology 1998;124(4):685-92.
1998: Duda D; Lorenz W; Dick W; Celik I; Black A; Healy M J; Black J W
Can clinically relevant histamine release be accurately diagnosed in anaesthetised patients without plasma histamine measurements? Randomised study with nested sampling aimed to change paradigms.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1998;47 Suppl 1():S73-4.
1997: Black J W; Owen D A; Parsons M E
An analysis of the depressor responses to histamine in the cat and dog: involvement of both H1- and H2-receptors. 1975.
British journal of pharmacology 1997;120(4 Suppl):420-5; discussion 419.
1997: Black J W; Duncan W A; Shanks R G
Comparison of some properties of pronethalol and propranolol. 1965.
British journal of pharmacology 1997;120(4 Suppl):285-99; discussion 283-4.
1996: Hills D M; Gerskowitch V P; Roberts S P; Welsh N J; Shankley N P; Black J W
Pharmacological analysis of the CCKB/gastrin receptors mediating pentagastrin-stimulated gastric acid secretion in the isolated stomach of the immature rat.
British journal of pharmacology 1996;119(7):1401-10.
1996: Van der Graaf P H; Shankley N P; Black J W
Analysis of the action of idazoxan calls into question the reliability of the rat isolated small mesenteric artery assay as a predictor for alpha 1-adrenoceptor-mediated pressor activity.
Naunyn-Schmiedeberg's archives of pharmacology 1996;354(3):389-92.
1996: Roberts S P; Harper E A; Watt G F; Gerskowitch V P; Hull R A; Shankley N P; Black J W
Analysis of the variation in the action of L-365,260 at CCKB/gastrin receptors in rat, guinea-pig and mouse isolated gastric tissue assays.
British journal of pharmacology 1996;118(7):1779-89.
1996: Harper E A; Roberts S P; Shankley N P; Black J W
Analysis of variation in L-365,260 competition curves in radioligand binding assays.
British journal of pharmacology 1996;118(7):1717-26.
1996: Van der Graaf P H; Shankley N P; Black J W
Analysis of the effects of alpha 1-adrenoceptor antagonists on noradrenaline-mediated contraction of rat small mesenteric artery.
British journal of pharmacology 1996;118(5):1308-16.
1996: Van der Graaf P H; Shankley N P; Black J W
Analysis of the activity of alpha 1-adrenoceptor antagonists in rat aorta.
British journal of pharmacology 1996;118(2):299-310.
1996: Black J W
TiPS on identity.
Trends in pharmacological sciences 1996;17(4):121.
1995: Van der Graaf P H; Saxena P R; Shankley N P; Black J W
Exposure and characterization of the action of noradrenaline at dopamine receptors mediating endothelium-independent relaxation of rat isolated small mesenteric arteries.
British journal of pharmacology 1995;116(8):3237-42.
1995: Welsh N J; Shankley N P; Black J W
Application of a model to explore interspecies differences in acetylcholine M-receptor-stimulated gastric acid secretion.
British journal of pharmacology 1995;115(6):961-8.
1995: Prentice D J; Shankley N P; Black J W
Pharmacological analysis of the interaction between purinoceptor agonists and antagonists in the guinea-pig taenia caecum.
British journal of pharmacology 1995;115(4):549-56.
1995: Black J W; Shankley N P
Drug receptors. Inverse agonists exposed.
Nature 1995;374(6519):214-5.
1995: Shankley N P; Watt G F; Black J W
Definition and localization of histamine H2 receptors.
European journal of clinical investigation 1995;25 Suppl 1():12-8.
1995: Bishop L A; Gerskowitch V P; Hull R A; Shankley N P; Black J W
The use of receptor desensitization to analyse CCKA and CCKB/gastrin receptors coupled to contraction in guinea-pig stomach muscle.
British journal of pharmacology 1995;114(2):339-48.
1994: Black J W; Duncan W A; Emmett J C; Ganellin C R; Hesselbo T; Parsons M E; Wyllie J H
Metiamide--an orally active histamine H2-receptor antagonist. 1973.
Agents and actions 1994;43(3-4):91-5; discussion 96.
1994: Welsh N J; Shankley N P; Black J W
Comparative analysis of the vagal stimulation of gastric acid secretion in rodent isolated stomach preparations.
British journal of pharmacology 1994;112(1):93-6.
1993: Black J
Reflections on the analytical pharmacology of histamine h2-receptor antagonists.
Gastroenterology 1993;105(4):963-8.
1993: Welsh N J; Shankley N P; Black J W
Comparative study of the control of basal acid output from rodent isolated stomachs.
British journal of pharmacology 1993;109(4):941-5.
1993: Hull R A; Shankley N P; Harper E A; Gerkowitch V P; Black J W
2-Naphthalenesulphonyl L-aspartyl-(2-phenethyl)amide (2-NAP)--a selective cholecystokinin CCKA-receptor antagonist.
British journal of pharmacology 1993;108(3):734-40.
1992: Shankley N P; Welsh N J; Black J W
Histamine dependence of pentagastrin-stimulated gastric acid secretion in rats.
The Yale journal of biology and medicine 1992;65(6):613-9.
1992: Liu Y J; Shankley N P; Welsh N J; Black J W
Evidence that the apparent complexity of receptor antagonism by angiotensin II analogues is due to a reversible and syntopic action.
British journal of pharmacology 1992;106(2):233-41.
1992: Bishop L A; Gerskowitch V P; Hull R A; Shankley N P; Black J W
Combined dose-ratio analysis of cholecystokinin receptor antagonists, devazepide, lorglumide and loxiglumide in the guinea-pig gall bladder.
British journal of pharmacology 1992;106(1):61-6.
1992: Barraclough P; Black J W; Cambridge D; Firmin D; Gerskowitch V P; Glen R C; Giles H; Gillam J M; Hull R A; Iyer R
Inotropic polyazapentalene sulmazole analogues.
Archiv der Pharmazie 1992;325(4):225-34.
1991: Durant P A; Shankley N P; Welsh N J; Black J W
Pharmacological analysis of agonist-antagonist interactions at acetylcholine muscarinic receptors in a new urinary bladder assay.
British journal of pharmacology 1991;104(1):145-50.
1990: Barraclough P; Black J W; Cambridge D; Demaine D A; Gerskowitch V P; Giles H; Hill A P; Hull R A; Lyer R; King W R
Cardiotonic 'C' ring modified isomazole analogues.
Archiv der Pharmazie 1990;323(8):507-12.
1990: Barraclough P; Black J W; Cambridge D; Gerskowitch V P; Hull R A; Lyer R; King W R; Kneen C O; Nobbs M S; Shah G P
Inotropic activities of imidazopyridines.
Archiv der Pharmazie 1990;323(8):501-5.
1990: Barraclough P; Black J W; Cambridge D; Collard D; Firmin D; Gerskowitch V P; Glen R C; Giles H; Hill A P; Hull R A
Inotropic "A" ring substituted sulmazole and isomazole analogues.
Journal of medicinal chemistry 1990;33(8):2231-9.
1990: Black J W
Neurochemical control of oxyntic cell secretion.
Hepato-gastroenterology 1990;37 Suppl 1():31-5.
1990: Black J W; Shankley N P
Interpretation of agonist affinity estimations: the question of distributed receptor states.
Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character. Royal Society (Great Britain) 1990;240(1299):503-18.
1989: Black J
Drugs from emasculated hormones: the principle of syntopic antagonism.
Science (New York, N.Y.) 1989;245(4917):486-93.
1989: Black J
Drugs from emasculated hormones: the principle of syntopic antagonism.
Bioscience reports 1989;9(3):253-72.
1989: Black J
Nobel lecture in physiology or medicine--1988. Drugs from emasculated hormones: the principle of syntopic antagonism.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1989;25(4):311-20.
1988: Shankley N P; Black J W; Ganellin C R; Mitchell R C
Correlation between log POCT/H2O and pKB estimates for a series of muscarinic and histamine H2-receptor antagonists.
British journal of pharmacology 1988;94(1):264-74.
1987: Trist D G; Leff P; Black J; Gerskowitch V P; Shankley N P
Resultant action of cimetidine in a cardiac adenylate cyclase assay: its elucidation by concentration-ratios analysis.
The Journal of pharmacology and experimental therapeutics 1987;243(3):1043-7.
1986: Black J W; Gerskowitch V P; Leff P; Shankley N P
Analysis of competitive antagonism when this property occurs as part of a pharmacological resultant.
British journal of pharmacology 1986;89(3):547-55.
1986: Black J W
Pharmacology: analysis and exploration.
British medical journal (Clinical research ed.) 1986;293(6541):252-5.
1986: Black J W; Shankley N P
Pharmacological analysis of the inhibition by pirenzepine and atropine of vagal-stimulated acid secretion in the isolated stomach of the mouse.
British journal of pharmacology 1986;88(1):291-7.
1986: Black J
Basic drug research in universities and industry.
British journal of clinical pharmacology 1986;22 Suppl 1():5S-7S.
1985: Black J W; Shankley N P
Pharmacological analysis of muscarinic receptors coupled to oxyntic cell secretion in the mouse stomach.
British journal of pharmacology 1985;86(3):601-7.
1985: Black J W; Leff P; Shankley N P
Pharmacological analysis of the pentagastrin-tiotidine interaction in the mouse isolated stomach.
British journal of pharmacology 1985;86(3):589-99.
1985: Black J W; Leff P; Shankley N P
Further analysis of anomalous pKB values for histamine H2-receptor antagonists on the mouse isolated stomach assay.
British journal of pharmacology 1985;86(3):581-7.
1985: Black J W; Shankley N P
Pharmacological analysis of the muscarinic receptors involved when McN-A 343 stimulates acid secretion in the mouse isolated stomach.
British journal of pharmacology 1985;86(3):609-17.
1985: Black J W; Shankley N P
The isolated stomach preparation of the mouse: a physiological unit for pharmacological analysis.
British journal of pharmacology 1985;86(3):571-9.
1985: Black J W; Gerskowitch V P; Leff P; Shankley N P
Pharmacological analysis of beta-adrenoceptor-mediated agonism in the guinea-pig, isolated, right atrium.
British journal of pharmacology 1985;84(3):779-85.
1985: Black J W; Leff P; Shankley N P; Wood J
An operational model of pharmacological agonism: the effect of E/[A] curve shape on agonist dissociation constant estimation.
British journal of pharmacology 1985;84(2):561-71.
1984: Vincenc K; Black J; Shaw J
Relaxation and contraction responses to histamine in the human lung parenchymal strip.
European journal of pharmacology 1984;98(2):201-10.
1983: Black J W; Leff P
Operational models of pharmacological agonism.
Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character. Royal Society (Great Britain) 1983;220(1219):141-62.
1982: Angus J A; Black J W
The interaction of choline esters, vagal stimulation and H2-receptor blockade on acid secretion in vitro.
European journal of pharmacology 1982;80(2-3):217-24.
1980: Black J W; Jenkinson D H; Kenakin T P
Antagonism of an indirectly acting agonist: block by propranolol and sotalol of the action of tyramine on rat heart.
European journal of pharmacology 1980;65(1):1-10.
1980: Angus J A; Black J W
Pharmacological assay of cardiac H2-receptor blockade by amitriptyline and lysergic acid diethylamide.
Circulation research 1980;46(6 Pt 2):I64-9.
1980: Angus J A; Black J W; Stone M
Estimation of pKB values for histamine H2-receptor antagonists using an in vitro acid secretion assay.
British journal of pharmacology 1980;68(3):413-23.
1979: Angus J A; Black J W
Analysis of anomalous pKb values for metiamide and atropine in the isolated stomach of the mouse.
British journal of pharmacology 1979;67(1):59-65.
1979: Black J W; Bradbury J E; Wyllie J H
Stimulation of colonic mucus output in the rat [proceedings]
British journal of pharmacology 1979;66(3):456P-457P.
1979: Black J W
Propranolol and cimetidine.
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 1979;41(2):166-72.
1978: Black J W
Antidepressants and histamine.
Lancet 1978;2(8079):53-4.
1978: Kenakin T P; Black J W
The pharmacological classification of practolol and chloropractolol.
Molecular pharmacology 1978;14(4):607-23.
1978: Black J W; Jenkinson D H; Welch L
Analysis of the interaction between histamine H2-receptor antagonists and pentagastrin [proceedings]
Agents and actions 1978;8(4):383-4.
1978: Angus J A; Black J W
Production of acid secretion in the mouse isolated stomach by electrical field stimulation [proceedings]
British journal of pharmacology 1978;62(3):460P.
1978: Angus J A; Black J W; Stone M
Comparative assay of histamine H2-receptor antagonists using the isolated mouse stomach [proceedings]
British journal of pharmacology 1978;62(3):445P-446P.
1977: Black J W; Welch L A
Are gastrin receptors located on parietal cells [proceedings]?
British journal of pharmacology 1977;59(3):476P.
1977: Kenakin T P; Black J W
Can chloropractolol alkylate beta adrenoceptors?
Nature 1977;265(5592):365-6.
1976: Black J W
Histamine H2-receptor antagonists and gastric acid secretion -- a progress report.
Klinische Wochenschrift 1976;54(19):911-4.
1976: Wan B Y; Black J W
Proceedings: Effects of dibutyryl cyclic AMP and phosphodiesterase inhibitors on acid secretion by mouse stomach in vitro.
British journal of pharmacology 1976;56(3):357P-358P.
1976: Black J W
Ahlquist and the development of beta-adrenoceptor antagonists.
Postgraduate medical journal 1976;52 Suppl 4():11-13.
1975: Durant G J; Parsons M E; Black J W
Potential histamine H2-receptor antagonists. 2. N-alpha-Guanylhistamine.
Journal of medicinal chemistry 1975;18(8):830-3.
1975: Black J W; Owen D A; Parsons M E
An analysis of the depressor responses to histamine in the cat and dog: involvement of both H1- and H2-receptors.
British journal of pharmacology 1975;54(3):319-24.
1975: Brimblecombe R W; Duncan W A; Durant G J; Ganellin C R; Parsons M E; Black J W
The pharmacology of cimetidine, a new histamine H2-receptor antagonist.
British journal of pharmacology 1975;53(3):435P-436P.
1974: Black J W; Durant G J; Emmett J C; Ganellin C R
Sulphur-methylene isosterism in the development of metiamide, a new histamine H2-receptor antagonist.
Nature 1974;248(443):65-7.
1973: Black J W; Duncan W A; Emmett J C; Ganellin C R; Hesselbo T; Parsons M E; Wyllie J H
Metiamide--an orally active histamine H2-receptor antagonist.
Agents and actions 1973;3(3):133-7.
1972: Wyllie J H; Hesselbo T; Black J W
The effect of burimamide on gastric secretion in man.
The British journal of surgery 1972;59(11):902-3.
1972: Wyllie J H; Hesselbo T; Black J W
Effects in man of histamine H 2 -receptor blockade by burimamide.
Lancet 1972;2(7787):1117-20.
1972: Black J W; Duncan W A; Durant C J; Ganellin C R; Parsons E M
Definition and antagonism of histamine H 2 -receptors.
Nature 1972;236(5347):385-90.
1965: Black J W; Duncan W A; Shanks R G
Comparison of some properties of pronethalol and propranolol.
British journal of pharmacology and chemotherapy 1965;25(3):577-91.
1960: BLACK J W
[Electrocardiographic changes produced in rabbits by vasopressin (pitressin) and their alteration by prolonged treatment with a commercial heart extract.]
The Journal of pharmacy and pharmacology 1960;12():87-94.

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