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Axel Schambach

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Martijn Brugman; Olga S Kustikova; Ute Modlich; Michael Rothe; Axel Schambach; Sebastian Suerbaum; Julia D Suerth; Christopher Baum
Evaluating a ligation-mediated PCR and pyrosequencing method for the detection of clonal contribution in polyclonal retrovirally transduced samples.
Olga S Kustikova; Zhixiong Li; T Neumann; Ingo Roeder; Axel Schambach; Brigitte Schlegelberger; A Schwarzer; M Stahlhut; Doris Steinemann; M Yang; Martijn Brugman; S Gerdes; T C Ha; N Heinz; Christopher Baum
Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells.
Daniel Kotlarz; Peter M Krawitz; Hans Kreipe; Monica G Lawrence; Joshua D Milner; Susan Moir; Stefan Mundlos; Dietmar Pfeifer; Eva-Doreen Pfister; Peter N Robinson; Alejandro A Schäffer; Axel Schambach; Petra Schwille; Gulbu Uzel; Thomas Weidemann; Jacek Puchałka; Natalia Zietara; Ulrich Baumann; Christian J Braun; Jana Diestelhorst; E Michael Gertz; Eric P Hanson; Jochen Hecht; Roland Jacobs; Lela Kardava; Christoph Klein
Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome.

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2013: Martijn Brugman; Olga S Kustikova; Ute Modlich; Michael Rothe; Axel Schambach; Sebastian Suerbaum; Julia D Suerth; Christopher Baum
Evaluating a ligation-mediated PCR and pyrosequencing method for the detection of clonal contribution in polyclonal retrovirally transduced samples.
Human gene therapy methods 2013;24(2):68-79.
2013: Olga S Kustikova; Zhixiong Li; T Neumann; Ingo Roeder; Axel Schambach; Brigitte Schlegelberger; A Schwarzer; M Stahlhut; Doris Steinemann; M Yang; Martijn Brugman; S Gerdes; T C Ha; N Heinz; Christopher Baum
Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells.
Leukemia 2013;27(5):1127-38.
2013: Daniel Kotlarz; Peter M Krawitz; Hans Kreipe; Monica G Lawrence; Joshua D Milner; Susan Moir; Stefan Mundlos; Dietmar Pfeifer; Eva-Doreen Pfister; Peter N Robinson; Alejandro A Schäffer; Axel Schambach; Petra Schwille; Gulbu Uzel; Thomas Weidemann; Jacek Puchałka; Natalia Zietara; Ulrich Baumann; Christian J Braun; Jana Diestelhorst; E Michael Gertz; Eric P Hanson; Jochen Hecht; Roland Jacobs; Lela Kardava; Christoph Klein
Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome.
The Journal of experimental medicine 2013;210(3):433-43.
2013: Nils Pfaff; Axel Schambach; Heiner Niemann; Mania Ackermann; Michael N Antoniou; Christian Brendel; Tobias Cantz; Manuel Grez; Saskia Kohlscheen; Nico Lachmann; Tobias Maetzig; Thomas Moritz
A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny.
Stem cells (Dayton, Ohio) 2013;31(3):488-99.
2013: N Lachmann; Ute Modlich; Christopher Baum; S Brennig; J Dahlmann; Ina Gruh; N Pfaff; R Phaltane; Axel Schambach; H Schermeier; T Moritz
Efficient in vivo regulation of cytidine deaminase expression in the haematopoietic system using a doxycycline-inducible lentiviral vector system.
Gene therapy 2013;20(3):298-307.
2013: Axel Schambach; Daniela Zychlinski; Birgitta Ehrnstroem; Christopher Baum
Biosafety features of lentiviral vectors.
Human gene therapy 2013;24(2):132-42.
2013: Bala Sai Sundarasetty; Thomas Woelfel; Chiara Bonini; Sylvia Borchers; Constanca Figueiredo; Arnold Ganser; Robert Geffers; Urban Gullberg; Laura Macke; Elena Provasi; Mareike Rickmann; Gustavo Salguero; Axel Schambach; Vijay Kumar Singh; Renata Stripecke
Lentivirus-induced dendritic cells for immunization against high-risk WT1(+) acute myeloid leukemia.
Human gene therapy 2013;24(2):220-37.
2013: Melanie Galla; Axel Schambach; Christopher Baum
Retrovirus-based mRNA transfer for transient cell manipulation.
Methods in molecular biology (Clifton, N.J.) 2013;969():139-61.
2012: Anastasia Wiedemann; Olena Pogozhykh; Axel Schambach; Jens C Schwamborn; Inga Bernemann; Rainer Blasczyk; Constanca Figueiredo; Silke Glage; Gudrun Göhring; Kathrin Hemmer; Thomas Müller
Induced pluripotent stem cells generated from adult bone marrow-derived cells of the nonhuman primate (Callithrix jacchus) using a novel quad-cistronic and excisable lentiviral vector.
Cellular reprogramming 2012;14(6):485-96.
2012: Stephanie Wunderlich; Sylvia Merkert; Axel Schambach; Kristin Schwanke; Jennifer Beier; Eliza C Curnow; Silke Glage; Gudrun Göhring; Alexandra Haase; Ulrich Martin
Induction of pluripotent stem cells from a cynomolgus monkey using a polycistronic simian immunodeficiency virus-based vector, differentiation toward functional cardiomyocytes, and generation of stably expressing reporter lines.
Cellular reprogramming 2012;14(6):471-84.
2012: Axel Schambach; Christopher Baum
Vectorizing mRNA and proteins.
Current gene therapy 2012;12(5):345-6.
2012: Julia D Suerth; Axel Schambach; Christopher Baum
Genetic modification of lymphocytes by retrovirus-based vectors.
Current opinion in immunology 2012;24(5):598-608.
2012: Tobias Maetzig; Christopher Baum; Axel Schambach
Retroviral protein transfer: falling apart to make an impact.
Current gene therapy 2012;12(5):389-409.
2012: N Lachmann; T Maetzig; Ute Modlich; S Brennig; Tobias Cantz; B Gentner; Dirk Heckl; J Jagielska; N Pfaff; Axel Schambach; T Moritz
MicroRNA-150-regulated vectors allow lymphocyte-sparing transgene expression in hematopoietic gene therapy.
Gene therapy 2012;19(9):915-24.
2012: Anna Otte; Tjoung-Won Park-Simon; Axel Schambach; Brigitte Schlegelberger; Doris Steinemann; Peter Hillemanns; Hans-Heinrich Kreipe; Florian Länger; Thomas Neumann; Gudrun Göhring; Stephanie Groos; Ralf Hass
A tumor-derived population (SCCOHT-1) as cellular model for a small cell ovarian carcinoma of the hypercalcemic type.
International journal of oncology 2012;41(2):765-75.
2012: J C M van der Loo; David A Williams; M Cavazzana-Calvo; E Grassman; Salima Hacein-Bey-Abina; T Higashimoto; D L Nordling; Lilith Reeves; Axel Schambach; W P Swaney; A Terwilliger; A J Thrasher; P Malik
Critical variables affecting clinical-grade production of the self-inactivating gamma-retroviral vector for the treatment of X-linked severe combined immunodeficiency.
Gene therapy 2012;19(8):872-6.
2012: Felicitas Thol; Katharina Wagner; Eva M Weissinger; Martin Wichmann; Haiyang Yun; David Bowen; Gesine Bug; Frederik Damm; Arnold Ganser; Gudrun Göhring; Torsten Haferlach; Wolf-Karsten Hofmann; Jürgen Krauter; Ken Mills; Michael Morgan; Oliver Ottmann; Axel Schambach; Brigitte Schlegelberger; Ann-Kathrin Sonntag; Michael Heuser
Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes.
Annals of hematology 2012;91(8):1221-33.
2012: Anusara Daenthanasanmak; Britta Eiz-Vesper; Constanca Figueiredo; Arnold Ganser; Roland Jacobs; Gustavo Salguero; Axel Schambach; Andreas Schneider; Rainer Blasczyk; Sylvia Borchers; Bala Sai Sundarasetty; Eva M Weissinger; Renata Stripecke
Integrase-defective lentiviral vectors encoding cytokines induce differentiation of human dendritic cells and stimulate multivalent immune responses in vitro and in vivo.
Vaccine 2012;30(34):5118-31.
2012: Hartmut Geiger; John H Griffin; Christopher Baum; Jose A Cancelas; Jose Á Fernández; Louis M Fink; Qiang Fu; Irene Hernandez; Edward J Kerschen; Olga Kustikova; Hai Po H Liang; Kalpana J Nattamai; Snehalata A Pawar; Karl-Uwe Petersen; MA Ryan; Axel Schambach; Junru Wang; Hartmut Weiler; Daohong Zhou; Martin Hauer-Jensen
Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity.
Nature medicine 2012;18(7):1123-9.
2012: Lars U Mueller; In-Hyun Park; Kalindi Parmar; Axel Schambach; Thorsten Schlaeger; Kelly Strait; Rutesh Vyas; Kristina M Brumme; George Q Daley; Alan D'Andrea; Alexander L Devine; Elke Grassman; Chad E Harris; Wendy B London; Michael D Milsom; Lisa A Moreau; David A Williams
Overcoming reprogramming resistance of Fanconi anemia cells.
Blood 2012;119(23):5449-57.
2012: Julia D Suerth; Manfred Schmidt; Jens-Uwe Appelt; Christopher Baum; Martijn Brugman; Manuel Grez; Niels Heinz; Kerstin B Kaufmann; Tobias Maetzig; Ute Modlich; Axel Schambach
Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(5):1022-32.
2012: Hengameh Abdollahpour; Giridharan Appaswamy; Rita Beier; Jana Diestelhorst; Karin R Engelhardt; E Michael Gertz; Bodo Grimbacher; Daniel Kotlarz; Hans H Kreipe; Sabine Lohrmann; Dietmar Pfeifer; Nima Rezaei; Alejandro A Schäffer; Axel Schambach; Roya Sherkat; Christoph Klein
The phenotype of human STK4 deficiency.
Blood 2012;119(15):3450-7.
2012: Sebastian Brennig; Nico Lachmann; Ina Rattmann; Axel Schambach; David A Williams; Thomas Moritz
In vivo enrichment of cytidine deaminase gene-modified hematopoietic cells by prolonged cytosine-arabinoside application.
Cytotherapy 2012;14(4):451-60.
2012: M Rothe; U Rüdrich; Axel Schambach; M Ott; I Rittelmeyer; Christopher Baum; M Bock; S Glage; M Iken; Michael P Manns; Ute Modlich
Epidermal growth factor improves lentivirus vector gene transfer into primary mouse hepatocytes.
Gene therapy 2012;19(4):425-34.
2012: Nils Pfaff; Axel Schambach; Malte Sgodda; Heiner Niemann; Marcos J Arauzo-Bravo; Christopher Baum; Tobias Cantz; Silke Glage; Boris Greber; Saskia Kohlscheen; Wilfried Kues; Nico Lachmann; Thomas Moritz
Efficient hematopoietic redifferentiation of induced pluripotent stem cells derived from primitive murine bone marrow cells.
Stem cells and development 2012;21(5):689-701.
2012: Christine Voelkel; Philip N Dannhauser; Melanie Galla; Tobias Maetzig; Axel Schambach; Beate Sodeik; Christopher Baum
Pseudotype-independent nonspecific uptake of gammaretroviral and lentiviral particles in human cells.
Human gene therapy 2012;23(3):274-86.
2012: J C M van der Loo; David A Williams; Christopher Baum; E Grassman; T Higashimoto; D L Nordling; Lilith Reeves; Axel Schambach; W P Swaney; A Terwilliger; A J Thrasher; P Malik
Scale-up and manufacturing of clinical-grade self-inactivating γ-retroviral vectors by transient transfection.
Gene therapy 2012;19(3):246-54.
2012: Sarah Knippenberg; Reinhard Dengler; Ralf Hass; Axel Schambach; Kerstin Schwabe; Nadine Thau; Susanne Petri
Intraspinal injection of human umbilical cord blood-derived cells is neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis.
Neuro-degenerative diseases 2012;9(3):107-20.
2011: Nils Pfaff; Axel Schambach; Tobias Cantz; Jan Fiedler; Angelika Holzmann; Thomas Moritz; Thomas Thum
miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2.
EMBO reports 2011;12(11):1153-9.
2011: Inés Avedillo Díez; Christopher Baum; Kaan Boztug; Emanuele G Coci; Ricardo A Dewey; Melanie Galla; Elmar Jaeckel; Christoph Klein; Tobias Maetzig; Ute Modlich; Nonsikelelo Mpofu; Adrian Schwarzer; Daniela Zychlinski; Axel Schambach
Development of novel efficient SIN vectors with improved safety features for Wiskott-Aldrich syndrome stem cell based gene therapy.
Molecular pharmaceutics 2011;8(5):1525-37.
2011: Juliane W Schott; Christopher Baum; Melanie Galla; Tamaryin Godinho; Axel Schambach
Viral and non-viral approaches for transient delivery of mRNA and proteins.
Current gene therapy 2011;11(5):382-98.
2011: Marshall W Huston; Yuedan Li; Fulvio Mavilio; Ali Nowrouzi; Axel Schambach; Manfred Schmidt; Adrian J Thrasher; Niek P van Til; Monique M A Verstegen; Trudi P Visser; Christof von Kalle; Shazia Arshad; Christopher Baum; Mike P Blundell; Martijn Brugman; Claudia Cattoglio; Fang Zhang; Gerard Wagemaker
Correction of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(10):1867-77.
2011: Melanie Galla; Gudrun Göhring; Niels Heinz; Zoltán Ivics; Zsuzsanna Izsvák; Johannes Kuehle; Kathrin Lange; Tobias Maetzig; Axel Schambach; Daniela Zychlinski; Martijn Brugman; Christine S Falk; Christopher Baum
Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery.
Nucleic acids research 2011;39(16):7147-60.
2011: Shiqiang Zhang; Ping Zhao; Daniela Zychlinski; Shen Chen; Yan Chen; Xiangpeng Guo; Wen Li; Xiaorong Liu; Hai Lu; Qiong Pan; Duanqing Pei; Axel Schambach; Micky D Tortorella; Yan Wang; Jianyong Xu; Miguel A Esteban
Rescue of ATP7B function in hepatocyte-like cells from Wilson's disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin.
Human molecular genetics 2011;20(16):3176-87.
2011: Guangming Wu; Holm Zaehres; Martina Bleidissel; Luca Gentile; Boris Greber; Dong Wook Han; Na Liu; Michael Ott; Ina Rittelmeyer; Cornelia Rudolph; Axel Schambach; Hans R Schöler; Malte Sgodda; Amar Deep Sharma; Doris Steinemann; Tobias Cantz
Generation of healthy mice from gene-corrected disease-specific induced pluripotent stem cells.
PLoS biology 2011;9(7):e1001099.
2011: Tobias Maetzig; Christopher Baum; Melanie Galla; Axel Schambach
Gammaretroviral vectors: biology, technology and application.
Viruses 2011;3(6):677-713.
2011: Ulf Tiemann; Malte Sgodda; Eva Warlich; Matthias Ballmaier; Hans R Schöler; Axel Schambach; Tobias Cantz
Optimal reprogramming factor stoichiometry increases colony numbers and affects molecular characteristics of murine induced pluripotent stem cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2011;79(6):426-35.
2011: Razvan Iacob; Urda Rüdrich; Michael Rothe; Sarah Kirsch; Benjamin Maasoumy; Nidhi Narain; Catherine M Verfaillie; Pau Sancho-Bru; Marcus Iken; Irinel Popescu; Axel Schambach; Michael P Manns; Michael Bock
Induction of a mature hepatocyte phenotype in adult liver derived progenitor cells by ectopic expression of transcription factors.
Stem cell research 2011;6(3):251-61.
2011: Dirk Heckl; Daniel C Wicke; Martijn Brugman; Johann Meyer; Axel Schambach; Guntram Büsche; Matthias Ballmaier; Christopher Baum; Ute Modlich
Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia.
Blood 2011;117(14):3737-47.
2011: Eva Warlich; Johannes Kuehle; Tobias Cantz; Martijn Brugman; Tobias Maetzig; Melanie Galla; Adam A Filipczyk; Stephan Halle; Hannes Klump; Hans R Schöler; Christopher Baum; Timm Schroeder; Axel Schambach
Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(4):782-9.
2011: Tobias Maetzig; Martijn Brugman; Stefan Bartels; Niels Heinz; Olga S Kustikova; Ute Modlich; Zhixiong Li; Melanie Galla; Bernhard Schiedlmeier; Axel Schambach; Christopher Baum
Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells.
Blood 2011;117(11):3053-64.
2011: Niels Heinz; Axel Schambach; Melanie Galla; Tobias Maetzig; Christopher Baum; Rainer Loew; Bernhard Schiedlmeier
Retroviral and transposon-based tet-regulated all-in-one vectors with reduced background expression and improved dynamic range.
Human gene therapy 2011;22(2):166-76.
2010: Soeren Turan; Johannes Kuehle; Axel Schambach; Christopher Baum; Juergen Bode
Multiplexing RMCE: versatile extensions of the Flp-recombinase-mediated cassette-exchange technology.
Journal of molecular biology 2010;402(1):52-69.
2010: Magda Tomala; Antonina Lavrentieva; Pierre Moretti; Ursula Rinas; Cornelia Kasper; Frank Stahl; Axel Schambach; Eva Warlich; Ulrich Martin; Tobias Cantz; Thomas Scheper
Preparation of bioactive soluble human leukemia inhibitory factor from recombinant Escherichia coli using thioredoxin as fusion partner.
Protein expression and purification 2010;73(1):51-7.
2010: Axel Schambach; Tobias Cantz; Christopher Baum; Toni Cathomen
Generation and genetic modification of induced pluripotent stem cells.
Expert opinion on biological therapy 2010;10(7):1089-103.
2010: Julia D Suerth; Tobias Maetzig; Melanie Galla; Christopher Baum; Axel Schambach
Self-inactivating alpharetroviral vectors with a split-packaging design.
Journal of virology 2010;84(13):6626-35.
2010: Christine Voelkel; Melanie Galla; Tobias Maetzig; Eva Warlich; Johannes Kuehle; Daniela Zychlinski; Juergen Bode; Tobias Cantz; Axel Schambach; Christopher Baum
Protein transduction from retroviral Gag precursors.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(17):7805-10.
2010: T Maetzig; Melanie Galla; Martijn Brugman; R Loew; Christopher Baum; Axel Schambach
Mechanisms controlling titer and expression of bidirectional lentiviral and gammaretroviral vectors.
Gene therapy 2010;17(3):400-11.
2010: Melanie Wurm; Axel Schambach; Dirk Lindemann; Helmut Hanenberg; Ludger Ständker; Wolf-Georg Forssmann; Rainer Blasczyk; Peter A Horn
The influence of semen-derived enhancer of virus infection on the efficiency of retroviral gene transfer.
The journal of gene medicine 2010;12(2):137-46.
2009: Ute Modlich; Susana Navarro; Daniela Zychlinski; Tobias Maetzig; Sabine Knoess; Martijn Brugman; Axel Schambach; Sabine Charrier; Anne Galy; Adrian J Thrasher; Juan Bueren; Christopher Baum
Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(11):1919-28.
2009: Julia Skokowa; Dan Lan; Basant Kumar Thakur; Fei Wang; Kshama Gupta; Gunnar Cario; Annette Müller Brechlin; Axel Schambach; Lars Hinrichsen; Gustav Meyer; Matthias Gaestel; Martin Stanulla; Qiang Tong; Karl Welte
NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway.
Nature medicine 2009;15(2):151-8.
2009: Axel Schambach; William P Swaney; Johannes C M van der Loo
Design and production of retro- and lentiviral vectors for gene expression in hematopoietic cells.
Methods in molecular biology (Clifton, N.J.) 2009;506():191-205.
2009: Ute Modlich; Axel Schambach; Zhixiong Li; Bernhard Schiedlmeier
Murine hematopoietic stem cell transduction using retroviral vectors.
Methods in molecular biology (Clifton, N.J.) 2009;506():23-31.
2008: Michael D Milsom; Moran Jerabek-Willemsen; Chad E Harris; Axel Schambach; Emily Broun; Jeff Bailey; Michael Jansen; David Schleimer; Kalpana Nattamai; Jamie Wilhelm; Amanda Watson; Hartmut Geiger; Geoffrey P Margison; Thomas Moritz; Christopher Baum; Jürgen Thomale; David A Williams
Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells.
Cancer research 2008;68(15):6171-80.
2008: Ute Modlich; Axel Schambach; Martijn Brugman; D C Wicke; S Knoess; Zhixiong Li; T Maetzig; Cornelia Rudolph; Brigitte Schlegelberger; Christopher Baum
Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16.
Leukemia 2008;22(8):1519-28.
2008: Lars U Mueller; Michael D Milsom; Mi-Ok Kim; Axel Schambach; Todd Schuesler; David A Williams
Rapid lentiviral transduction preserves the engraftment potential of Fanca(-/-) hematopoietic stem cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(6):1154-60.
2008: Daniela Zychlinski; Axel Schambach; Ute Modlich; Tobias Maetzig; Johann Meyer; Elke Grassman; Anjali Mishra; Christopher Baum
Physiological promoters reduce the genotoxic risk of integrating gene vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(4):718-25.
2008: Melanie Galla; Axel Schambach; Greg J Towers; Christopher Baum
Cellular restriction of retrovirus particle-mediated mRNA transfer.
Journal of virology 2008;82(6):3069-77.
2008: Susannah I Thornhill; Axel Schambach; Steven J Howe; Meera Ulaganathan; Elke Grassman; David Williams; Bernhard Schiedlmeier; Neil J Sebire; H Bobby Gaspar; Christine Kinnon; Christopher Baum; Adrian J Thrasher
Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(3):590-8.
2008: Amar Deep Sharma; Tobias Cantz; Arndt Vogel; Axel Schambach; Dhivya Haridass; Markus Iken; Martina Bleidissel; Michael P Manns; Hans R Schöler; Michael Ott
Murine embryonic stem cell-derived hepatic progenitor cells engraft in recipient livers with limited capacity of liver tissue formation.
Cell transplantation 2008;17(3):313-23.
2007: Christopher Baum; Axel Schambach; Ute Modlich; A Thrasher
[Gene therapy of SCID-X1].
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 2007;50(12):1507-17.
2007: Michael Heuser; Bob Argiropoulos; Florian Kuchenbauer; Eric Yung; Jessica Piper; Stephen Fung; Richard F Schlenk; Konstanze Dohner; Tanja Hinrichsen; Cornelia Rudolph; Axel Schambach; Christopher Baum; Brigitte Schlegelberger; Hartmut Dohner; Arnold Ganser; R Keith Humphries
MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML.
Blood 2007;110(5):1639-47.
2007: Fang Zhang; Susannah I Thornhill; Steven J Howe; Meera Ulaganathan; Axel Schambach; Joanna Sinclair; Christine Kinnon; H Bobby Gaspar; Michael Antoniou; Adrian J Thrasher
Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells.
Blood 2007;110(5):1448-57.
2007: Axel Schambach; Christopher Baum
Vector design for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells.
DNA repair 2007;6(8):1187-96.
2007: Axel Schambach; Melanie Galla; Tobias Maetzig; Rainer Loew; Christopher Baum
Improving transcriptional termination of self-inactivating gamma-retroviral and lentiviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(6):1167-73.
2007: Jens Bohne; Axel Schambach; Daniela Zychlinski
New way of regulating alternative splicing in retroviruses: the promoter makes a difference.
Journal of virology 2007;81(7):3652-6.
2006: Axel Schambach; D Mueller; Melanie Galla; M M A Verstegen; Gerard Wagemaker; R Loew; Christopher Baum; Jens Bohne
Overcoming promoter competition in packaging cells improves production of self-inactivating retroviral vectors.
Gene therapy 2006;13(21):1524-33.
2006: Ute Modlich; Jens Bohne; Manfred Schmidt; Christof von Kalle; Sabine Knöss; Axel Schambach; Christopher Baum
Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity.
Blood 2006;108(8):2545-53.
2006: Julia Skokowa; Gunnar Cario; Murat Uenalan; Axel Schambach; Manuela Germeshausen; Karin Battmer; Cornelia Zeidler; Ulrich Lehmann; Matthias Eder; Christopher Baum; Rudolf Grosschedl; Martin Stanulla; Michaela Scherr; Karl Welte
LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia.
Nature medicine 2006;12(10):1191-7.
2006: Adrian J Thrasher; H Bobby Gaspar; Christopher Baum; Ute Modlich; Axel Schambach; Fabio Candotti; Makoto Otsu; Brian P Sorrentino; Linda Scobie; Ewan Cameron; Karen Blyth; Jim Neil; Salima Hacein-Bey Abina; Marina Cavazzana-Calvo; Alain Fischer
Gene therapy: X-SCID transgene leukaemogenicity.
Nature 2006;443(7109):E5-6; discussion E6-7.
2006: Axel Schambach; Bernhard Schiedlmeier; Klaus Kühlcke; M Verstegen; Geoffrey P Margison; Zhixiong Li; K Kamino; Jens Bohne; Alexander Alexandrov; Felix Hermann; Dorothee von Laer; Christopher Baum
Towards hematopoietic stem cell-mediated protection against infection with human immunodeficiency virus.
Gene therapy 2006;13(13):1037-47.
2006: Christopher Baum; Axel Schambach; Jens Bohne; Melanie Galla
Retrovirus vectors: toward the plentivirus?
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(6):1050-63.
2006: Axel Schambach; Melanie Galla; Ute Modlich; Elke Will; Saurabh Chandra; Lilith Reeves; Melissa Colbert; David A Williams; Christof von Kalle; Christopher Baum
Lentiviral vectors pseudotyped with murine ecotropic envelope: increased biosafety and convenience in preclinical research.
Experimental hematology 2006;34(5):588-92.
2006: Axel Schambach; Jens Bohne; Christopher Baum; Felix Hermann; L Egerer; Dorothee von Laer; Tsanan Giroglou
Woodchuck hepatitis virus post-transcriptional regulatory element deleted from X protein and promoter sequences enhances retroviral vector titer and expression.
Gene therapy 2006;13(7):641-5.
2006: Axel Schambach; Jens Bohne; Saurabh Chandra; Elke Will; Geoffrey P Margison; David A Williams; Christopher Baum
Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(2):391-400.
2004: Oliver Frank; Cornelia Rudolph; Christoph Heberlein; Nils von neuhoff; Evelin Schröck; Axel Schambach; Brigitte Schlegelberger; Boris Fehse; Wolfram Ostertag; Carol Stocking; Christopher Baum
Tumor cells escape suicide gene therapy by genetic and epigenetic instability.
Blood 2004;104(12):3543-9.
2004: Janine Kraunus; D H S Schaumann; Johann Meyer; Ute Modlich; Boris Fehse; Gunda Brandenburg; Dorothee von Laer; Hannes Klump; Axel Schambach; Jens Bohne; Christopher Baum
Self-inactivating retroviral vectors with improved RNA processing.
Gene therapy 2004;11(21):1568-78.
2000: Axel Schambach; Harald Wodrich; M Hildinger; Jens Bohne; Hans-Georg Kräusslich; Christopher Baum
Context dependence of different modules for posttranscriptional enhancement of gene expression from retroviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;2(5):435-45.
2000: Harald Wodrich; Axel Schambach; Hans-Georg Kräusslich
Multiple copies of the Mason-Pfizer monkey virus constitutive RNA transport element lead to enhanced HIV-1 Gag expression in a context-dependent manner.
Nucleic acids research 2000;28(4):901-10.