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Luis Schang

Research Profile

Chemicals & Drugs

Physiology

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Publications

TOP 3
Che C Colpitts; Raquel F Epand; Richard M Epand; Vladimir A Korshun; Alexey V Ustinov; Luis M Schang
5-(Perylen-3-yl)ethynyl-arabino-uridine (aUY11), an arabino-based rigid amphipathic fusion inhibitor, targets virion envelope lipids to inhibit fusion of influenza virus, hepatitis C virus, and other enveloped viruses.
R B Gombos; J C Brown; K L Conn; R L Gibeault; Luis M Schang; J Teefy; Denise G Hemmings
Vascular dysfunction in young, mid-aged and aged mice with latent cytomegalovirus infections.
Jonathan J Lacasse; Luis M Schang
Herpes simplex virus 1 DNA is in unstable nucleosomes throughout the lytic infection cycle, and the instability of the nucleosomes is independent of DNA replication.

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All Publications

2013: Che C Colpitts; Raquel F Epand; Richard M Epand; Vladimir A Korshun; Alexey V Ustinov; Luis M Schang
5-(Perylen-3-yl)ethynyl-arabino-uridine (aUY11), an arabino-based rigid amphipathic fusion inhibitor, targets virion envelope lipids to inhibit fusion of influenza virus, hepatitis C virus, and other enveloped viruses.
Journal of virology 2013;87(7):3640-54.
2013: R B Gombos; J C Brown; K L Conn; R L Gibeault; Luis M Schang; J Teefy; Denise G Hemmings
Vascular dysfunction in young, mid-aged and aged mice with latent cytomegalovirus infections.
American journal of physiology. Heart and circulatory physiology 2013;304(2):H183-94.
2012: Jonathan J Lacasse; Luis M Schang
Herpes simplex virus 1 DNA is in unstable nucleosomes throughout the lytic infection cycle, and the instability of the nucleosomes is independent of DNA replication.
Journal of virology 2012;86(20):11287-300.
2011: Kristen L Conn; Michael Hendzel; Luis M Schang
Core histones H2B and H4 are mobilized during infection with herpes simplex virus 1.
Journal of virology 2011;85(24):13234-52.
2011: Sandra Ciesek; Che C Colpitts; Martina Friesland; Michael P Manns; Philip Meuleman; Michael Ott; Thomas Pietschmann; Luis M Schang; Jörg Steinmann; Thomas von Hahn; Heiner Wedemeyer; Eike Steinmann
The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry.
Hepatology (Baltimore, Md.) 2011;54(6):1947-55.
2011: Nasser Samadi; Luis M Schang; Raie T Bekele; Ing Swie Goping; David N Brindley
Lysophosphatidate induces chemo-resistance by releasing breast cancer cells from taxol-induced mitotic arrest.
PloS one 2011;6(5):e20608.
2010: Mireille R St Vincent; Che C Colpitts; Alexey V Ustinov; Muhammad Muqadas; Michael A Joyce; Nicola L Barsby; Raquel F Epand; Richard M Epand; Stanislav A Khramyshev; Olga A Valueva; Vladimir A Korshun; D Lorne J Tyrrell; Luis M Schang
Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped viruses.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(40):17339-44.
2010: Aja M Rieger; Brian E Hall; Le Thuong Luong; Luis M Schang; Daniel R Barreda
Conventional apoptosis assays using propidium iodide generate a significant number of false positives that prevent accurate assessment of cell death.
Journal of immunological methods 2010;358(1-2):81-92.
2010: Jonathan J Lacasse; Luis M Schang
During lytic infections, herpes simplex virus type 1 DNA is in complexes with the properties of unstable nucleosomes.
Journal of virology 2010;84(4):1920-33.
2008: Kristen L Conn; Michael Hendzel; Luis M Schang
Linker histones are mobilized during infection with herpes simplex virus type 1.
Journal of virology 2008;82(17):8629-46.
2006: Luis M Schang
First demonstration of the effectiveness of inhibitors of cellular protein kinases in antiviral therapy.
Expert review of anti-infective therapy 2006;4(6):953-6.
2006: Katherine E Morris; Luis M Schang; David N Brindley
Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts.
The Journal of biological chemistry 2006;281(14):9297-306.
2006: Luis M Schang; Mireille R St Vincent; Jonathan J Lacasse
Five years of progress on cyclin-dependent kinases and other cellular proteins as potential targets for antiviral drugs.
Antiviral chemistry & chemotherapy 2006;17(6):293-320.
2006: Luis M Schang
Herpes simplex viruses in antiviral drug discovery.
Current pharmaceutical design 2006;12(11):1357-70.
2005: Luis M Schang
Discovery of the antiviral activities of pharmacologic cyclin-dependent kinase inhibitors: from basic to applied science.
Expert review of anti-infective therapy 2005;3(2):145-9.
2005: Luis M Schang; Ersilia Coccaro; Jonathan J Lacasse
Cdk inhibitory nucleoside analogs prevent transcription from viral genomes.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):829-37.
2004: Claudia Banchio; Luis M Schang; Dennis E Vance
Phosphorylation of Sp1 by cyclin-dependent kinase 2 modulates the role of Sp1 in CTP:phosphocholine cytidylyltransferase alpha regulation during the S phase of the cell cycle.
The Journal of biological chemistry 2004;279(38):40220-6.
2004: Prerna Diwan; Jonathan J Lacasse; Luis M Schang
Roscovitine inhibits activation of promoters in herpes simplex virus type 1 genomes independently of promoter-specific factors.
Journal of virology 2004;78(17):9352-65.
2004: Luis M Schang
Effects of pharmacological cyclin-dependent kinase inhibitors on viral transcription and replication.
Biochimica et biophysica acta 2004;1697(1-2):197-209.
2004: Véronic Marie Isabelle Provencher; Ersilia Coccaro; Jonathan J Lacasse; Luis M Schang
Antiviral drugs that target cellular proteins may play major roles in combating HIV resistance.
Current pharmaceutical design 2004;10(32):4081-101.
2003: Claudia Banchio; Luis M Schang; Dennis E Vance
Activation of CTP:phosphocholine cytidylyltransferase alpha expression during the S phase of the cell cycle is mediated by the transcription factor Sp1.
The Journal of biological chemistry 2003;278(34):32457-64.
2003: Luis M Schang
The cell cycle, cyclin-dependent kinases, and viral infections: new horizons and unexpected connections.
Progress in cell cycle research 2003;5():103-24.
2002: Luis M Schang
Cyclin-dependent kinases as cellular targets for antiviral drugs.
The Journal of antimicrobial chemotherapy 2002;50(6):779-92.
2002: Luis M Schang; Andrew Bantly; Marie Knockaert; Farida Shaheen; Laurent Meijer; Michael H Malim; Nathanael S Gray; Priscilla A Schaffer
Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins.
Journal of virology 2002;76(15):7874-82.
2002: Luis M Schang; Andrew Bantly; Priscilla A Schaffer
Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4.
Journal of virology 2002;76(15):7724-35.
2001: Luis M Schang
Antiviral symposium and workshop--eighth international meeting.
IDrugs : the investigational drugs journal 2001;4(2):161-7.
2001: Luis M Schang
Cellular proteins (cyclin dependent kinases) as potential targets for antiviral drugs.
Antiviral chemistry & chemotherapy 2001;12 Suppl 1():157-78.
2000: Luis M Schang; G J Hwang; Brian David Dynlacht; David W Speicher; Andrew Bantly; Priscilla A Schaffer; Ali Shilatifard; H Ge; Ramin Shiekhattar
Human PC4 is a substrate-specific inhibitor of RNA polymerase II phosphorylation.
The Journal of biological chemistry 2000;275(9):6071-4.
2000: Luis M Schang; A Rosenberg; Priscilla A Schaffer
Roscovitine, a specific inhibitor of cellular cyclin-dependent kinases, inhibits herpes simplex virus DNA synthesis in the presence of viral early proteins.
Journal of virology 2000;74(5):2107-20.
1999: Robert Jordan; Luis M Schang; Priscilla A Schaffer
Transactivation of herpes simplex virus type 1 immediate-early gene expression by virion-associated factors is blocked by an inhibitor of cyclin-dependent protein kinases.
Journal of virology 1999;73(10):8843-7.
1999: Luis M Schang; A Rosenberg; Priscilla A Schaffer
Transcription of herpes simplex virus immediate-early and early genes is inhibited by roscovitine, an inhibitor specific for cellular cyclin-dependent kinases.
Journal of virology 1999;73(3):2161-72.
1998: Luis M Schang; J Phillips; Priscilla A Schaffer
Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription.
Journal of virology 1998;72(7):5626-37.