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Julio Scharfstein

Research Profile

Chemicals & Drugs

Disorders

Chagas' Disease

Genes & Molecular Sequences

Amino Acid Sequences

Living Beings

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Anatomy

T-Lymphocytes

Physiology

Signal Transduction

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Publications

TOP 3
Erik Svensjö; Mauro M Teixeira; Rafael Silveira Amendola; Christina Barja-Fidalgo; Marcelo T Bozza; Ethan A Lerner; Elvira M B Saraiva; Julio Scharfstein
Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1-CXCR1/2-pathway.
Daniele Andrade; Fabio S Fortes; Ana Paula C A Lima; Verônica Morandi; Ana Carolina F Morandini; Erivan S Ramos; Rafaela Serra; Maria de N Soeiro; Erik Svensjö; Herbert B Tanowitz; Julio Scharfstein
Trypanosoma cruzi invades host cells through the activation of endothelin and bradykinin receptors: a converging pathway leading to chagasic vasculopathy.
Naiara Miranda Rust; Julio Scharfstein; Aline Miranda Scovino; Carlos Eduardo Calzavara-Silva; Mayara Marques Carneiro da Silva; Ernesto Marques; Michelle Premazzi Papa; Ligia Maria Torres Peçanha; Luciana B Arruda
Bradykinin enhances Sindbis virus infection in human brain microvascular endothelial cells.

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All Publications

2012: Erik Svensjö; Mauro M Teixeira; Rafael Silveira Amendola; Christina Barja-Fidalgo; Marcelo T Bozza; Ethan A Lerner; Elvira M B Saraiva; Julio Scharfstein
Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1-CXCR1/2-pathway.
Microvascular research 2012;83(2):185-93.
2012: Daniele Andrade; Fabio S Fortes; Ana Paula C A Lima; Verônica Morandi; Ana Carolina F Morandini; Erivan S Ramos; Rafaela Serra; Maria de N Soeiro; Erik Svensjö; Herbert B Tanowitz; Julio Scharfstein
Trypanosoma cruzi invades host cells through the activation of endothelin and bradykinin receptors: a converging pathway leading to chagasic vasculopathy.
British journal of pharmacology 2012;165(5):1333-47.
2012: Naiara Miranda Rust; Julio Scharfstein; Aline Miranda Scovino; Carlos Eduardo Calzavara-Silva; Mayara Marques Carneiro da Silva; Ernesto Marques; Michelle Premazzi Papa; Ligia Maria Torres Peçanha; Luciana B Arruda
Bradykinin enhances Sindbis virus infection in human brain microvascular endothelial cells.
Virology 2012;422(1):81-91.
2012: Julio Scharfstein; Erik Svensjö; Daniele Andrade; Ana Carolina Oliveira; Clarissa R Nascimento
The kallikrein-kinin system in experimental Chagas disease: a paradigm to investigate the impact of inflammatory edema on GPCR-mediated pathways of host cell invasion by Trypanosoma cruzi.
Frontiers in immunology 2012;3():396.
2012: Dirlei Nico; Marcos Palatnik; Daniel Ferreira Feijó; Naiara Maran; Alexandre Morrot; Julio Scharfstein; Clarisa Beatriz Palatnik de Sousa
Resistance to visceral leishmaniasis is severely compromised in mice deficient of bradykinin B2-receptors.
Parasites & vectors 2012;5():261.
2009: Ana Carolina Monteiro; Aline Scovino; Susane Raposo; Vinicius Mussa Gaze; Catia Cruz; Erik Svensjö; Marcelo Sampaio Narciso; Ana Paula Colombo; João B Pesquero; Eduardo Feres-Filho; Ky-Anh Nguyen; Aneta Sroka; Jan Potempa; Julio Scharfstein
Kinin danger signals proteolytically released by gingipain induce Fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3700-11.
2009: Julio Scharfstein; Juliana de Assis Silva Gomes; Rodrigo Correa-Oliveira
Back to the future in Chagas disease: from animal models to patient cohort studies, progress in immunopathogenesis research.
Memórias do Instituto Oswaldo Cruz 2009;104 Suppl 1():187-98.
2009: Dennis Grab; JOSE GARCIA-GARCIA; Olga V Nikolskaia; Yuri V Kim; AMANDA BROWN; CARLOS PARDO-VILLAMIZAR; Yongqing Zhang; Kevin G Becker; Brenda A Wilson; Ana Paula C de A Lima; Julio Scharfstein; John Dumler
Protease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cells.
PLoS neglected tropical diseases 2009;3(7):e479.
2009: Erik Svensjö; Elvira M B Saraiva; Marcelo T Bozza; Sandra M P Oliveira; Ethan A Lerner; Julio Scharfstein
Salivary gland homogenates of Lutzomyia longipalpis and its vasodilatory peptide maxadilan cause plasma leakage via PAC1 receptor activation.
Journal of vascular research 2009;46(5):435-46.
2008: Julio Scharfstein; Ana Carolina Monteiro; Verônica Schmitz; Erik Svensjö
Angiotensin-converting enzyme limits inflammation elicited by Trypanosoma cruzi cysteine proteases: a peripheral mechanism regulating adaptive immunity via the innate kinin pathway.
Biological chemistry 2008;389(8):1015-24.
2008: Ana Carolina Dos Santos Monteiro; Osmundo Brilhante de Oliveira Neto; Rafael Perseghini Del Sarto; Mariana Torquato Q de Magalhães; Janaina Nascimento Lima; Ariane Ferreira Lacerda; Raquel Sampaio Oliveira; Julio Scharfstein; Maria Cristina Mattar da Silva; Jorge W Arboleda Valencia; Arnubio Valencia Jiménez; Maria Fátima Grossi-De-Sa
A recombinant form of chagasin from Trypanosoma cruzi: inhibitory activity on insect cysteine proteinases.
Pest management science 2008;64(7):755-60.
2008: Flavia C G dos Reis; Brian O Smith; Camila Chaves Santos; Tatiana F R Costa; Julio Scharfstein; Graham H Coombs; Jeremy C Mottram; Ana Paula C A Lima
The role of conserved residues of chagasin in the inhibition of cysteine peptidases.
FEBS letters 2008;582(4):485-90.
2008: Julio Scharfstein; Ana Paula C A Lima
Roles of naturally occurring protease inhibitors in the modulation of host cell signaling and cellular invasion by Trypanosoma cruzi.
Sub-cellular biochemistry 2008;47():140-54.
2007: Ana Carolina Monteiro; Verônica Schmitz; Alexandre Morrot; Luciana Barros de Arruda; Fnu Nagajyothi; Alessandra Granato; João B Pesquero; Werner Müller-Esterl; Herbert B Tanowitz; Julio Scharfstein
Bradykinin B2 Receptors of dendritic cells, acting as sensors of kinins proteolytically released by Trypanosoma cruzi, are critical for the development of protective type-1 responses.
PLoS pathogens 2007;3(11):e185.
2007: Julio Scharfstein; Verônica Schmitz; Erik Svensjö; A Granato; Ana Carolina Monteiro
Kininogens coordinate adaptive immunity through the proteolytic release of bradykinin, an endogenous danger signal driving dendritic cell maturation.
Scandinavian journal of immunology 2007;66(2-3):128-36.
2007: Stephanie X Wang; Kailash C Pandey; Julio Scharfstein; James C Whisstock; Rick K Huang; Jordan Jacobelli; Robert J Fletterick; Philip J Rosenthal; Magnus Abrahamson; Linda S Brinen; Andrea Rossi; Andrej Sali; James H McKerrow
The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family.
Structure (London, England : 1993) 2007;15(5):535-43.
2007: Flavia C G Reis; Tatiana F R Costa; Traian Sulea; Alessandra Mezzetti; Julio Scharfstein; Dieter Brömme; Robert Ménard; Ana Paula C A Lima
The propeptide of cruzipain--a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F.
The FEBS journal 2007;274(5):1224-34.
2006: Ana Carolina Monteiro; Verônica Schmitz; Erik Svensjö; Ricardo T Gazzinelli; Igor Almeida; Alex G Todorov; Luciana Barros de Arruda; Ana Cláudia T Torrecilhas; João B Pesquero; Alexandre Morrot; Eliete Bouskela; Adriana Bonomo; Ana Paula C A Lima; Werner Müller-Esterl; Julio Scharfstein
Cooperative activation of TLR2 and bradykinin B2 receptor is required for induction of type 1 immunity in a mouse model of subcutaneous infection by Trypanosoma cruzi.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6325-35.
2006: Olga V Nikolskaia; Ana Paula C de A Lima; Yuri V Kim; John D Lonsdale-Eccles; Toshihide Fukuma; Julio Scharfstein; Dennis Grab
Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease.
The Journal of clinical investigation 2006;116(10):2739-47.
2006: Camila Chaves Santos; Julio Scharfstein; Ana Paula C A Lima
Role of chagasin-like inhibitors as endogenous regulators of cysteine proteases in parasitic protozoa.
Parasitology research 2006;99(4):323-4.
2006: Flavia C G dos Reis; Wagner A S Júdice; Maria A Juliano; Luiz Juliano; Julio Scharfstein; Ana Paula C A Lima
The substrate specificity of cruzipain 2, a cysteine protease isoform from Trypanosoma cruzi.
FEMS microbiology letters 2006;259(2):215-20.
2006: Didier Salmon; Rodolpho do Aido-Machado; Anne Diehl; Martina Leidert; Oliver Schmetzer; Ana Paula C de A Lima; Julio Scharfstein; Hartmut Oschkinat; Juliana Rico Pires
Solution structure and backbone dynamics of the Trypanosoma cruzi cysteine protease inhibitor chagasin.
Journal of molecular biology 2006;357(5):1511-21.
2006: Rodolpho do Aido-Machado; Didier Salmon; Anne Diehl; Martina Leidert; Oliver Schmetzer; Ana Paula Pereira Thiapó de Lima; Julio Scharfstein; Hartmut Oschkinat; Juliana Rico Pires
1H, 15N and 13C assignments of the cysteine protease inhibitor chagasin from Trypanosoma cruzi.
Journal of biomolecular NMR 2006;36 Suppl 1():30.
2006: Julio Scharfstein
Parasite cysteine proteinase interactions with alpha 2-macroglobulin or kininogens: differential pathways modulating inflammation and innate immunity in infection by pathogenic trypanosomatids.
Immunobiology 2006;211(1-2):117-25.
2006: Erik Svensjö; Paulo R Batista; Cláudia Brodskyn; Robson Silva; Ana Paula C A Lima; Verônica Schmitz; Elvira M B Saraiva; João B Pesquero; Marcelo A S Mori; Werner Müller-Esterl; Julio Scharfstein
Interplay between parasite cysteine proteases and the host kinin system modulates microvascular leakage and macrophage infection by promastigotes of the Leishmania donovani complex.
Microbes and infection / Institut Pasteur 2006;8(1):206-20.
2005: Luciana L Penha; Lucia Mendonça-Previato; José O Previato; Julio Scharfstein; Norton Heise; Ana Paula C A Lima
Cloning and characterization of the phosphoglucomutase of Trypanosoma cruzi and functional complementation of a Saccharomyces cerevisiae PGM null mutant.
Glycobiology 2005;15(12):1359-67.
2005: Camila Chaves Santos; Clemax Couto Sant'anna; Amanda Terres; Narcisa L Cunha-e-Silva; Julio Scharfstein; Ana Paula C de A Lima
Chagasin, the endogenous cysteine-protease inhibitor of Trypanosoma cruzi, modulates parasite differentiation and invasion of mammalian cells.
Journal of cell science 2005;118(Pt 5):901-15.
2004: Isabela M Aparicio; Julio Scharfstein; Ana Paula C A Lima
A new cruzipain-mediated pathway of human cell invasion by Trypanosoma cruzi requires trypomastigote membranes.
Infection and immunity 2004;72(10):5892-902.
2003: Julio Aliberti; João P B Viola; Adriana Vieira-de-Abreu; Patrícia T Bozza; Alan Sher; Julio Scharfstein
Cutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(11):5349-53.
2003: Shankar Mukherjee; Huan Huang; Louis M Weiss; Sylvia Costa; Julio Scharfstein; Herbert B Tanowitz
Role of vasoactive mediators in the pathogenesis of Chagas' disease.
Frontiers in bioscience : a journal and virtual library 2003;8():e410-9.
2003: Alex G Todorov; Daniele Andrade; João B Pesquero; Ronaldo de Carvalho Araujo; Michael Bader; John Stewart; Lajos Gera; Werner Müller-Esterl; Verônica Morandi; Regina C S Goldenberg; Hugo Castro-Faria Neto; Julio Scharfstein
Trypanosoma cruzi induces edematogenic responses in mice and invades cardiomyocytes and endothelial cells in vitro by activating distinct kinin receptor (B1/B2) subtypes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(1):73-5.
2002: Anita R Schnapp; Christopher S Eickhoff; Julio Scharfstein; Daniel F Hoft
Induction of B- and T-cell responses to cruzipain in the murine model of Trypanosoma cruzi infection.
Microbes and infection / Institut Pasteur 2002;4(8):805-13.
2002: Gilles Lalmanach; Alain Boulangé; Carole Serveau; Fabien Lecaille; Julio Scharfstein; Francis Gauthier; Edith Authié
Congopain from Trypanosoma congolense: drug target and vaccine candidate.
Biological chemistry 2002;383(5):739-49.
2002: Ana Paula C A Lima; Paulo de Almeida; Ivarne L S Tersariol; Verônica Schmitz; Alvin H Schmaier; Luiz Juliano; Isaura Y Hirata; Werner Müller-Esterl; Jair R Chagas; Julio Scharfstein
Heparan sulfate modulates kinin release by Trypanosoma cruzi through the activity of cruzipain.
The Journal of biological chemistry 2002;277(8):5875-81.
2001: Wagner A S Judice; Maria Helena S Cezari; Ana Paula C A Lima; Julio Scharfstein; Jair R Chagas; Ivarne L S Tersariol; Maria A Juliano; Luiz Juliano
Comparison of the specificity, stability and individual rate constants with respective activation parameters for the peptidase activity of cruzipain and its recombinant form, cruzain, from Trypanosoma cruzi.
European journal of biochemistry / FEBS 2001;268(24):6578-86.
2001: Ana Carolina Monteiro; M Abrahamson; Ana Paula C A Lima; Marcos André Vannier-Santos; Julio Scharfstein
Identification, characterization and localization of chagasin, a tight-binding cysteine protease inhibitor in Trypanosoma cruzi.
Journal of cell science 2001;114(Pt 21):3933-42.
2001: Ana Paula C A Lima; Flavia C G dos Reis; Carole Serveau; Gilles Lalmanach; Luiz Juliano; Robert Ménard; Thierry Vernet; D Y Thomas; AC Storer; Julio Scharfstein
Cysteine protease isoforms from Trypanosoma cruzi, cruzipain 2 and cruzain, present different substrate preference and susceptibility to inhibitors.
Molecular and biochemical parasitology 2001;114(1):41-52.
2000: Julio Scharfstein; Verônica Schmitz; V Morandi; M M Capella; Ana Paula C A Lima; Alexandre Morrot; Luiz Juliano; Werner Müller-Esterl
Host cell invasion by Trypanosoma cruzi is potentiated by activation of bradykinin B(2) receptors.
The Journal of experimental medicine 2000;192(9):1289-300.
2000: V Yong; Verônica Schmitz; Marcos André Vannier-Santos; Ana Paula Pereira Thiapó de Lima; Gilles Lalmanach; Luiz Juliano; F Gauthier; Julio Scharfstein
Altered expression of cruzipain and a cathepsin B-like target in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine-proteinases.
Molecular and biochemical parasitology 2000;109(1):47-59.
2000: C M Meyer; Paul W Ladenson; Julio Scharfstein; Mark D Danese; Neil R Powe
Evaluation of common problems in primary care: effects of physician, practice, and financial characteristics.
The American journal of managed care 2000;6(4):457-69.
1999: Julio Scharfstein; Alexandre Morrot
A role for extracellular amastigotes in the immunopathology of Chagas disease.
Memórias do Instituto Oswaldo Cruz 1999;94 Suppl 1():51-63.
1999: Carole Serveau; Gilles Lalmanach; I Hirata; Julio Scharfstein; Maria A Juliano; Francis Gauthier
Discrimination of cruzipain, the major cysteine proteinase of Trypanosoma cruzi, and mammalian cathepsins B and L, by a pH-inducible fluorogenic substrate of trypanosomal cysteine proteinases.
European journal of biochemistry / FEBS 1999;259(1-2):275-80.
1998: Gilles Lalmanach; Fabien Lecaille; Jair R Chagas; Edith Authié; Julio Scharfstein; Maria A Juliano; Francis Gauthier
Inhibition of trypanosomal cysteine proteinases by their propeptides.
The Journal of biological chemistry 1998;273(39):25112-6.
1997: E Del Nery; Maria A Juliano; Ana Paula C A Lima; Julio Scharfstein; Luiz Juliano
Kininogenase activity by the major cysteinyl proteinase (cruzipain) from Trypanosoma cruzi.
The Journal of biological chemistry 1997;272(41):25713-8.
1997: Erik Svensjö; Fatima Z G A Cyrino; L Juliano; Julio Scharfstein
Plasma leakage induced in postcapillary venules by the major cysteine-proteinase from Trypanosoma cruzi and its modulation by H1-blocker mepyramine.
Microvascular research 1997;54(1):93-7.
1997: Alexandre Morrot; Dudley K Strickland; M de L Higuchi; M Reis; R Pedrosa; Julio Scharfstein
Human T cell responses against the major cysteine proteinase (cruzipain) of Trypanosoma cruzi: role of the multifunctional alpha 2-macroglobulin receptor in antigen presentation by monocytes.
International immunology 1997;9(6):825-34.
1996: Gilles Lalmanach; R Mayer; Carole Serveau; Julio Scharfstein; Francis Gauthier
Biotin-labelled peptidyl diazomethane inhibitors derived from the substrate-like sequence of cystatin: targeting of the active site of cruzipain, the major cysteine proteinase of Trypanosoma cruzi.
The Biochemical journal 1996;318 ( Pt 2)():395-9.
1996: Roberto Coury Pedrosa; E A Saad; Julio Scharfstein; A M Lima
[The proliferative response of T cells against cruzipain in chronic chagasic cardiopathy].
Revista da Sociedade Brasileira de Medicina Tropical 1996;29(4):331-9.
1996: Carole Serveau; Gilles Lalmanach; Maria A Juliano; Julio Scharfstein; Luiz Juliano; Francis Gauthier
Investigation of the substrate specificity of cruzipain, the major cysteine proteinase of Trypanosoma cruzi, through the use of cystatin-derived substrates and inhibitors.
The Biochemical journal 1996;313 ( Pt 3)():951-6.
1995: Julio Scharfstein; M Abrahamson; C B de Souza; Aldina Barral; I V Silva
Antigenicity of cystatin-binding proteins from parasitic protozoan. Detection by a proteinase inhibitor based capture immunoassay (PINC-ELISA).
Journal of immunological methods 1995;182(1):63-72.
1994: A P Lima; Daniel C Tessier; David Y Thomas; Julio Scharfstein; AC Storer; Thierry Vernet
Identification of new cysteine protease gene isoforms in Trypanosoma cruzi.
Molecular and biochemical parasitology 1994;67(2):333-8.
1993: A C Arnholdt; M R Piuvezam; DM Russo; A P Lima; Roberto Coury Pedrosa; Steven G Reed; Julio Scharfstein
Analysis and partial epitope mapping of human T cell responses to Trypanosoma cruzi cysteinyl proteinase.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(6):3171-9.
1993: Mecia M Oliveira; E D Rocha; Edson Rondinelli; A V Arnholdt; Julio Scharfstein
Signal transduction in Trypanosoma cruzi: opposite effects of adenylcyclase and phospholipase C systems in growth control.
Molecular and cellular biochemistry 1993;124(2):91-9.
1992: A P Lima; Julio Scharfstein; AC Storer; R Ménard
Temperature-dependent substrate inhibition of the cysteine proteinase (GP57/51) from Trypanosoma cruzi.
Molecular and biochemical parasitology 1992;56(2):335-8.
1992: M N L Meirelles; Luiz Juliano; E Carmona; S G Silva; E M Costa; A C Murta; Julio Scharfstein
Inhibitors of the major cysteinyl proteinase (GP57/51) impair host cell invasion and arrest the intracellular development of Trypanosoma cruzi in vitro.
Molecular and biochemical parasitology 1992;52(2):175-84.
1991: Maria Bellio; L M Leal; Julio Scharfstein; G A Dos Reis
Interactions between CD3 and Thy1 T cell activation pathways: blockade of CD3-mediated T lymphocyte activation induced by immobilized anti-Thy1 antibodies.
Cellular immunology 1991;135(2):534-40.
1991: A C Arnholdt; Julio Scharfstein
Immunogenicity of Trypanosoma cruzi cysteine proteinase.
Research in immunology 1991;142(2):146-51.
1991: Myrna Bonaldo; Julio Scharfstein; A C Murta; SAMUEL GOLDENBERG
Further characterization of Trypanosoma cruzi GP57/51 as the major antigen expressed by differentiating epimastigotes.
Parasitology research 1991;77(7):567-71.
1990: A C Murta; Pedro Persechini; T de S Padron; Wanderley de Souza; J A Guimarães; Julio Scharfstein
Structural and functional identification of GP57/51 antigen of Trypanosoma cruzi as a cysteine proteinase.
Molecular and biochemical parasitology 1990;43(1):27-38.
1988: A C Murta; V C Leme; S R Milani; Luiz Travassos; Julio Scharfstein
Glycoprotein GP57/51 of Trypanosoma cruzi: structural and conformational epitopes defined with monoclonal antibodies.
Memórias do Instituto Oswaldo Cruz 1988;83 Suppl 1():419-22.
1986: Julio Scharfstein; M Schechter; M Senna; J M Peralta; Lucia Mendonça-Previato; M A Miles
Trypanosoma cruzi: characterization and isolation of a 57/51,000 m.w. surface glycoprotein (GP57/51) expressed by epimastigotes and bloodstream trypomastigotes.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(4):1336-41.
1985: Julio Scharfstein; Alejandro O Luquetti; A C Murta; M Senna; J M Rezende; Anis Rassi; Lucia Mendonça-Previato
Chagas' disease: serodiagnosis with purified Gp25 antigen.
The American journal of tropical medicine and hygiene 1985;34(6):1153-60.
1983: Lucia Mendonça-Previato; Philip A J Gorin; A F Braga; Julio Scharfstein; José O Previato
Chemical structure and antigenic aspects of complexes obtained from epimastigotes of Trypanosoma cruzi.
Biochemistry 1983;22(21):4980-7.
1983: Julio Scharfstein; M M Rodrigues; C A Alves; W de Souza; José O Previato; Lucia Mendonça-Previato
Trypanosoma cruzi: description of a highly purified surface antigen defined by human antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1983;131(2):972-6.