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David Schatz

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
14
Fugmann, Sebastian
10
Livak, Ferenc
8
Hesslein, David
8
Baltimore, David
7
Eastman, QM
6
Shockett, Penny
6
Unniraman, Shyam
5
Tsai, Chia-Lun
4
Villey, IJ
4
Odegard, Valerie
4
Petrie, Howard
4
Pflugh, David
4
Ptaszek, Leon
4
Chatterji, Monalisa
4
Ciubotaru, Mihai

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Publications

TOP 3
Strout Matthew P; Schatz David G
Imatinib resistance and progression of CML to blast crisis: somatic hypermutation AIDing the way.
Yin Fang Fang; Bailey Scott; Innis C Axel; Ciubotaru Mihai; Kamtekar Satwik; Steitz Thomas A; Schatz David G
Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis.
Liu Man; Schatz David G
Balancing AID and DNA repair during somatic hypermutation.

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All Publications

2009: Strout Matthew P; Schatz David G
Imatinib resistance and progression of CML to blast crisis: somatic hypermutation AIDing the way.
Cancer cell 2009;16(3):174-6.
2009: Yin Fang Fang; Bailey Scott; Innis C Axel; Ciubotaru Mihai; Kamtekar Satwik; Steitz Thomas A; Schatz David G
Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis.
Nature structural & molecular biology 2009;16(5):499-508.
2009: Liu Man; Schatz David G
Balancing AID and DNA repair during somatic hypermutation.
Trends in immunology 2009;30(4):173-81.
2009: Hesslein David G T; Fretz Jackie A; Xi Yougen; Nelson Tracy; Zhou Shoaming; Lorenzo Joseph A; Schatz David G; Horowitz Mark C
Ebf1-dependent control of the osteoblast and adipocyte lineages.
Bone 2009;44(4):537-46.
2009: Giblin William; Chatterji Monalisa; Westfield Gerwin; Masud Tehmina; Theisen Brian; Cheng Hwei-Ling; DeVido Jeffrey; Alt Frederick W; Ferguson David O; Schatz David G; Sekiguchi JoAnn
Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation.
Blood 2009;113(13):2965-75.
2008: Liu Man; Duke Jamie L; Richter Daniel J; Vinuesa Carola G; Goodnow Christopher C; Kleinstein Steven H; Schatz David G
Two levels of protection for the B cell genome during somatic hypermutation.
Nature 2008;451(7180):841-5.
2007: Chatterji Monalisa; Unniraman Shyam; McBride Kevin M; Schatz David G
Role of activation-induced deaminase protein kinase A phosphorylation sites in Ig gene conversion and somatic hypermutation.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(8):5274-80.
2007: Drejer-Teel Anna H; Fugmann Sebastian D; Schatz David G
The beyond 12/23 restriction is imposed at the nicking and pairing steps of DNA cleavage during V(D)J recombination.
Molecular and cellular biology 2007;27(18):6288-99.
2007: Unniraman Shyam; Schatz David G
Strand-biased spreading of mutations during somatic hypermutation.
Science (New York, N.Y.) 2007;317(5842):1227-30.
2007: Yang Shu Yuan; Fugmann Sebastian D; Gramlich Hillary S; Schatz David G
Activation-induced cytidine deaminase-mediated sequence diversification is transiently targeted to newly integrated DNA substrates.
The Journal of biological chemistry 2007;282(35):25308-13.
2007: Ciubotaru Mihai; Kriatchko Aleksei N; Swanson Patrick C; Bright Frank V; Schatz David G
Fluorescence resonance energy transfer analysis of recombination signal sequence configuration in the RAG1/2 synaptic complex.
Molecular and cellular biology 2007;27(13):4745-58.
2007: Yang Shu Yuan; Schatz David G
Targeting of AID-mediated sequence diversification by cis-acting determinants.
Advances in immunology 2007;94():109-25.
2006: Yang Shu Yuan; Fugmann Sebastian D; Schatz David G
Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences.
The Journal of experimental medicine 2006;203(13):2919-28.
2006: Unniraman Shyam; Schatz David G
AID and Igh switch region-Myc chromosomal translocations.
DNA repair 2006;5(9-10):1259-64.
2006: Odegard Valerie H; Schatz David G
Targeting of somatic hypermutation.
Nature reviews. Immunology 2006;6(8):573-83.
2006: Inlay Matthew A; Gao Heather H; Odegard Valerie H; Lin Tongxiang; Schatz David G; Xu Yang
Roles of the Ig kappa light chain intronic and 3' enhancers in Igk somatic hypermutation.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):1146-51.
2006: Chatterji Monalisa; Tsai Chia-Lun; Schatz David G
Mobilization of RAG-generated signal ends by transposition and insertion in vivo.
Molecular and cellular biology 2006;26(4):1558-68.
2006: Hesslein David G T; Yang Shu Yuan; Schatz David G
Origins of peripheral B cells in IL-7 receptor-deficient mice.
Molecular immunology 2006;43(4):326-34.
2005: Horowitz Mark C; Bothwell Alfred L M; Hesslein David G T; Pflugh David L; Schatz David G
B cells and osteoblast and osteoclast development.
Immunological reviews 2005;208():141-53.
2005: Rush James S; Liu Man; Odegard Valerie H; Unniraman Shyam; Schatz David G
Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(37):13242-7.
2005: Odegard Valerie H; Kim Sean T; Anderson Shannon M; Shlomchik Mark J; Schatz David G
Histone modifications associated with somatic hypermutation.
Immunity 2005;23(1):101-10.
2005: Schatz D G; Spanopoulou E
Biochemistry of V(D)J recombination.
Current topics in microbiology and immunology 2005;290():49-85.
2004: Horowitz Mark C; Xi Yougen; Pflugh David L; Hesslein David G T; Schatz David G; Lorenzo Joseph A; Bothwell Alfred L M
Pax5-deficient mice exhibit early onset osteopenia with increased osteoclast progenitors.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6583-91.
2004: Unniraman Shyam; Zhou Shaoming; Schatz David G
Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc.
Nature immunology 2004;5(11):1117-23.
2004: Ciubotaru Mihai; Schatz David G
Synapsis of recombination signal sequences located in cis and DNA underwinding in V(D)J recombination.
Molecular and cellular biology 2004;24(19):8727-44.
2004: Schatz David G
Antigen receptor genes and the evolution of a recombinase.
Seminars in immunology 2004;16(4):245-56.
2004: Unniraman Shyam; Fugmann Sebastian D; Schatz David G
Immunology. UNGstoppable switching.
Science (New York, N.Y.) 2004;305(5687):1113-4.
2004: Johnson Kristen; Pflugh David L; Yu Duonan; Hesslein David G T; Lin Kuo-I; Bothwell Alfred L M; Thomas-Tikhonenko Andrei; Schatz David G; Calame Kathryn
B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5.
Nature immunology 2004;5(8):853-61.
2004: Chatterji Monalisa; Tsai Chia-Lun; Schatz David G
New concepts in the regulation of an ancient reaction: transposition by RAG1/RAG2.
Immunological reviews 2004;200():261-71.
2004: Schatz David G
V(D)J recombination.
Immunological reviews 2004;200():5-11.
2004: Repasky Jamie A E; Corbett Elizabeth; Boboila Cristian; Schatz David G
Mutational analysis of terminal deoxynucleotidyltransferase-mediated N-nucleotide addition in V(D)J recombination.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(9):5478-88.
2004: Rush James S; Fugmann Sebastian D; Schatz David G
Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination.
International immunology 2004;16(4):549-57.
2004: Fugmann Sebastian D; Rush James S; Schatz David G
Non-redundancy of cytidine deaminases in class switch recombination.
European journal of immunology 2004;34(3):844-9.
2004: Schatz David G; Baltimore David
Uncovering the V(D)J recombinase.
Cell 2004;116(2 Suppl):S103-6, 2 p following S106.
2004: Shockett Penny E; Zhou Shaoming; Hong Xiaoming; Schatz David G
Partial reconstitution of V(D)J rearrangement and lymphocyte development in RAG-deficient mice expressing inducible, tetracycline-regulated RAG transgenes.
Molecular immunology 2004;40(11):813-29.
2003: Tsai Chia-Lun; Chatterji Monalisa; Schatz David G
DNA mismatches and GC-rich motifs target transposition by the RAG1/RAG2 transposase.
Nucleic acids research 2003;31(21):6180-90.
2003: Lee Alfred Ian; Fugmann Sebastian D; Cowell Lindsay G; Ptaszek Leon M; Kelsoe Garnett; Schatz David G
A functional analysis of the spacer of V(D)J recombination signal sequences.
PLoS biology 2003;1(1):E1.
2003: Fugmann Sebastian D; Schatz David G
RNA AIDS DNA.
Nature immunology 2003;4(5):429-30.
2003: Tsai Chia-Lun; Schatz David G
Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2.
The EMBO journal 2003;22(8):1922-30.
2003: Rooney Sean; Alt Frederick W; Lombard David; Whitlow Scott; Eckersdorff Mark; Fleming James; Fugmann Sebastian; Ferguson David O; Schatz David G; Sekiguchi JoAnn
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells.
The Journal of experimental medicine 2003;197(5):553-65.
2003: Ciubotaru Mihai; Ptaszek Leon M; Baker Gary A; Baker Sheila N; Bright Frank V; Schatz David G
RAG1-DNA binding in V(D)J recombination. Specificity and DNA-induced conformational changes revealed by fluorescence and CD spectroscopy.
The Journal of biological chemistry 2003;278(8):5584-96.
2003: Jung David; Bassing Craig H; Fugmann Sebastian D; Cheng Hwei-Ling; Schatz David G; Alt Frederick W
Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells.
Immunity 2003;18(1):65-74.
2003: Hesslein David G T; Pflugh David L; Chowdhury Dipanjan; Bothwell Alfred L M; Sen Ranjan; Schatz David G
Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments.
Genes & development 2003;17(1):37-42.
2002: Tsai Chia-Lun; Drejer Anna H; Schatz David G
Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination.
Genes & development 2002;16(15):1934-49.
2002: Chen Jingshan; Kelz Max B; Zeng Guoqi; Steffen Cathy; Shockett Penny E; Terwilliger Gordon; Schatz David G; Nestler Eric J
Inducible, reversible hair loss in transgenic mice.
Transgenic research 2002;11(3):241-7.
2002: Papavasiliou F Nina; Schatz David G
The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process.
The Journal of experimental medicine 2002;195(9):1193-8.
2002: Papavasiliou F Nina; Schatz David G
Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity.
Cell 2002;109 Suppl():S35-44.
2002: Fugmann Sebastian D; Schatz David G
Immunology. One AID to unite them all.
Science (New York, N.Y.) 2002;295(5558):1244-5.
2001: Fugmann S D; Schatz D G
Identification of basic residues in RAG2 critical for DNA binding by the RAG1-RAG2 complex.
Molecular cell 2001;8(4):899-910.
2001: Hesslein D G; Fields P E; Schatz D G
Location, location, location: the cell biology of immunoglobulin allelic control.
Nature immunology 2001;2(9):825-6.
2001: Hesslein D G; Schatz D G
Factors and forces controlling V(D)J recombination.
Advances in immunology 2001;78():169-232.
2000: Papavasiliou F N; Schatz D G
Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes.
Nature 2000;408(6809):216-21.
2000: Livak F; Burtrum D B; Rowen L; Schatz D G; Petrie H T
Genetic modulation of T cell receptor gene segment usage during somatic recombination.
The Journal of experimental medicine 2000;192(8):1191-6.
2000: Tevelev A; Schatz D G
Intermolecular V(D)J recombination.
The Journal of biological chemistry 2000;275(12):8341-8.
2000: Fugmann S D; Villey I J; Ptaszek L M; Schatz D G
Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex.
Molecular cell 2000;5(1):97-107.
2000: Fugmann S D; Lee A I; Shockett P E; Villey I J; Schatz D G
The RAG proteins and V(D)J recombination: complexes, ends, and transposition.
Annual review of immunology 2000;18():495-527.
1999: Rodgers K K; Villey I J; Ptaszek L; Corbett E; Schatz D G; Coleman J E
A dimer of the lymphoid protein RAG1 recognizes the recombination signal sequence and the complex stably incorporates the high mobility group protein HMG2.
Nucleic acids research 1999;27(14):2938-46.
1999: Shockett P E; Schatz D G
DNA hairpin opening mediated by the RAG1 and RAG2 proteins.
Molecular and cellular biology 1999;19(6):4159-66.
1999: Eastman Q M; Villey I J; Schatz D G
Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking.
Molecular and cellular biology 1999;19(5):3788-97.
1999: Livák F; Tourigny M; Schatz D G; Petrie H T
Characterization of TCR gene rearrangements during adult murine T cell development.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2575-80.
1999: Eynon E E; Livák F; Kuida K; Schatz D G; Flavell R A
Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1448-59.
1999: Schatz D G
Transposition mediated by RAG1 and RAG2 and the evolution of the adaptive immune system.
Immunologic research 1999;19(2-3):169-82.
1998: Agrawal A; Eastman Q M; Schatz D G
Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system.
Nature 1998;394(6695):744-51.
1998: Livák F; Schatz D G
Alternative splicing of rearranged T cell receptor delta sequences to the constant region of the alpha locus.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(10):5694-9.
1997: Livák F; Wilson A; MacDonald H R; Schatz D G
Alpha beta lineage-committed thymocytes can be rescued by the gamma delta T cell receptor (TCR) in the absence of TCR beta chain.
European journal of immunology 1997;27(11):2948-58.
1997: Eastman Q M; Schatz D G
Nicking is asynchronous and stimulated by synapsis in 12/23 rule-regulated V(D)J cleavage.
Nucleic acids research 1997;25(21):4370-8.
1997: Leu T M; Eastman Q M; Schatz D G
Coding joint formation in a cell-free V(D)J recombination system.
Immunity 1997;7(2):303-14.
1997: McMahan C J; Difilippantonio M J; Rao N; Spanopoulou E; Schatz D G
A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity.
Molecular and cellular biology 1997;17(8):4544-52.
1997: Bellon S F; Rodgers K K; Schatz D G; Coleman J E; Steitz T A
Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster.
Nature structural biology 1997;4(7):586-91.
1997: Schatz D G
V(D)J recombination moves in vitro.
Seminars in immunology 1997;9(3):149-59.
1997: Agrawal A; Schatz D G
RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination.
Cell 1997;89(1):43-53.
1997: Livák F; Schatz D G
Identification of V(D)J recombination coding end intermediates in normal thymocytes.
Journal of molecular biology 1997;267(1):1-9.
1997: McMahan C J; Sadofsky M J; Schatz D G
Definition of a large region of RAG1 that is important for coimmunoprecipitation of RAG2.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2202-10.
1996: Han S; Zheng B; Schatz D G; Spanopoulou E; Kelsoe G
Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells.
Science (New York, N.Y.) 1996;274(5295):2094-7.
1996: Difilippantonio M J; McMahan C J; Eastman Q M; Spanopoulou E; Schatz D G
RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination.
Cell 1996;87(2):253-62.
1996: Livák F; Welsh S C; Guidos C J; Crispe I N; Danska J S; Schatz D G
Transient restoration of gene rearrangement at multiple T cell receptor loci in gamma-irradiated scid mice.
The Journal of experimental medicine 1996;184(2):419-28.
1996: Rodgers K K; Bu Z; Fleming K G; Schatz D G; Engelman D M; Coleman J E
A zinc-binding domain involved in the dimerization of RAG1.
Journal of molecular biology 1996;260(1):70-84.
1996: Eastman Q M; Leu T M; Schatz D G
Obeying V(D)J rules in vitro.
Immunology today 1996;17(5):205.
1996: Shockett P E; Schatz D G
Diverse strategies for tetracycline-regulated inducible gene expression.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5173-6.
1996: Grawunder U; Schatz D G; Leu T M; Rolink A; Melchers F
The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression.
The Journal of experimental medicine 1996;183(4):1731-7.
1996: Hoffman E S; Passoni L; Crompton T; Leu T M; Schatz D G; Koff A; Owen M J; Hayday A C
Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo.
Genes & development 1996;10(8):948-62.
1996: Eastman Q M; Leu T M; Schatz D G
Initiation of V(D)J recombination in vitro obeying the 12/23 rule.
Nature 1996;380(6569):85-8.
1996: Livak F; Schatz D G
T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells.
Molecular and cellular biology 1996;16(2):609-18.
1996: Schatz D G; Leu T M
rag-1 and rag-2: biochemistry and protein interactions.
Current topics in microbiology and immunology 1996;217():11-29.
1995: Grawunder U; Leu T M; Schatz D G; Werner A; Rolink A G; Melchers F; Winkler T H
Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement.
Immunity 1995;3(5):601-8.
1995: Leu T M; Schatz D G
rag-1 and rag-2 are components of a high-molecular-weight complex, and association of rag-2 with this complex is rag-1 dependent.
Molecular and cellular biology 1995;15(10):5657-70.
1995: Shockett P; Difilippantonio M; Hellman N; Schatz D G
A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(14):6522-6.
1995: Livak F; Petrie H T; Crispe I N; Schatz D G
In-frame TCR delta gene rearrangements play a critical role in the alpha beta/gamma delta T cell lineage decision.
Immunity 1995;2(6):617-27.
1994: Hubank M; Schatz D G
Identifying differences in mRNA expression by representational difference analysis of cDNA.
Nucleic acids research 1994;22(25):5640-8.
1993: Petrie H T; Livak F; Schatz D G; Strasser A; Crispe I N; Shortman K
Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.
The Journal of experimental medicine 1993;178(2):615-22.
1992: Schatz D G; Chun J J
V(D)J recombination and the transgenic brain blues.
The New biologist 1992;4(3):188-96.
1992: Oettinger M A; Stanger B; Schatz D G; Glaser T; Call K; Housman D; Baltimore D
The recombination activating genes, RAG 1 and RAG 2, are on chromosome 11p in humans and chromosome 2p in mice.
Immunogenetics 1992;35(2):97-101.
1992: Schatz D G; Oettinger M A; Schlissel M S
V(D)J recombination: molecular biology and regulation.
Annual review of immunology 1992;10():359-83.
1991: Turka L A; Schatz D G; Oettinger M A; Chun J J; Gorka C; Lee K; McCormack W T; Thompson C B
Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking.
Science (New York, N.Y.) 1991;253(5021):778-81.
1991: Carlson L M; Oettinger M A; Schatz D G; Masteller E L; Hurley E A; McCormack W T; Baltimore D; Thompson C B
Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion.
Cell 1991;64(1):201-8.
1991: Chun J J; Schatz D G; Oettinger M A; Jaenisch R; Baltimore D
The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system.
Cell 1991;64(1):189-200.
1990: Oettinger M A; Schatz D G; Gorka C; Baltimore D
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination.
Science (New York, N.Y.) 1990;248(4962):1517-23.
1989: Schatz D G; Oettinger M A; Baltimore D
The V(D)J recombination activating gene, RAG-1.
Cell 1989;59(6):1035-48.
1988: Schatz D G; Baltimore D
Stable expression of immunoglobulin gene V(D)J recombinase activity by gene transfer into 3T3 fibroblasts.
Cell 1988;53(1):107-15.
1987: Landau N R; Schatz D G; Rosa M; Baltimore D
Increased frequency of N-region insertion in a murine pre-B-cell line infected with a terminal deoxynucleotidyl transferase retroviral expression vector.
Molecular and cellular biology 1987;7(9):3237-43.

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