Roy Black

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Loesch Kimberly; Deng Luqin; Cowan Jon W; Wang Xiangdong; He Kai; Jiang Jing; Black Roy A; Frank Stuart J
Janus kinase 2 influences growth hormone receptor metalloproteolysis.
Cowan Jon W; Wang Xiangdong; Guan Ran; He Kai; Jiang Jing; Baumann Gerhard; Black Roy A; Wolfe Michael S; Frank Stuart J
Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage.
Wang Xiangdong; He Kai; Gerhart Mary; Jiang Jing; Paxton Raymond J; Menon Ram K; Black Roy A; Baumann Gerhard; Frank Stuart J
Reduced proteolysis of rabbit growth hormone (GH) receptor substituted with mouse GH receptor cleavage site.

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All Publications

2006: Loesch Kimberly; Deng Luqin; Cowan Jon W; Wang Xiangdong; He Kai; Jiang Jing; Black Roy A; Frank Stuart J
Janus kinase 2 influences growth hormone receptor metalloproteolysis.
Endocrinology 2006;147(6):2839-49.
2005: Cowan Jon W; Wang Xiangdong; Guan Ran; He Kai; Jiang Jing; Baumann Gerhard; Black Roy A; Wolfe Michael S; Frank Stuart J
Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage.
The Journal of biological chemistry 2005;280(19):19331-42.
2003: Wang Xiangdong; He Kai; Gerhart Mary; Jiang Jing; Paxton Raymond J; Menon Ram K; Black Roy A; Baumann Gerhard; Frank Stuart J
Reduced proteolysis of rabbit growth hormone (GH) receptor substituted with mouse GH receptor cleavage site.
Molecular endocrinology (Baltimore, Md.) 2003;17(10):1931-43.
2003: Doedens John R; Mahimkar Rajeev M; Black Roy A
TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation.
Biochemical and biophysical research communications 2003;308(2):331-8.
2003: Levin J I; Chen J M; Cheung K; Cole D; Crago C; Santos E Delos; Du X; Khafizova G; MacEwan G; Niu C; Salaski E J; Zask A; Cummons T; Sung A; Xu J; Zhang Y; Xu W; Ayral-Kaloustian S; Jin G; Cowling R; Barone D; Mohler K M; Black R A; Skotnicki J S
Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates.
Bioorganic & medicinal chemistry letters 2003;13(16):2799-803.
2003: Lee David C; Sunnarborg Susan Wohler; Hinkle C Leann; Myers Timothy J; Stevenson Mary Y; Russell William E; Castner Beverly J; Gerhart Mary J; Paxton Raymond J; Black Roy A; Chang Aileen; Jackson Leslie F
TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase.
Annals of the New York Academy of Sciences 2003;995():22-38.
2003: Black Roy A; Doedens John R; Mahimkar Rajeev; Johnson Richard; Guo Lin; Wallace Alison; Virca Duke; Eisenman June; Slack Jennifer; Castner Beverly; Sunnarborg Susan W; Lee David C; Cowling Rebecca; Jin Guixian; Charrier Keith; Peschon Jacques J; Paxton Ray
Substrate specificity and inducibility of TACE (tumour necrosis factor alpha-converting enzyme) revisited: the Ala-Val preference, and induced intrinsic activity.
Biochemical Society symposium 2003;(70):39-52.
2002: Wang Xiangdong; He Kai; Gerhart Mary; Huang Yao; Jiang Jing; Paxton Raymond J; Yang Shaohua; Lu Chunxia; Menon Ram K; Black Roy A; Baumann Gerhard; Frank Stuart J
Metalloprotease-mediated GH receptor proteolysis and GHBP shedding. Determination of extracellular domain stem region cleavage site.
The Journal of biological chemistry 2002;277(52):50510-9.
2002: Levin J I; Chen J M; Du M T; Nelson F C; Killar L M; Skala S; Sung A; Jin G; Cowling R; Barone D; March C J; Mohler K M; Black R A; Skotnicki J S
Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 2: SAR of the acetylenic P1' group.
Bioorganic & medicinal chemistry letters 2002;12(8):1199-202.
2002: Sunnarborg Susan Wohler; Hinkle C Leann; Stevenson Mary; Russell William E; Raska Christina S; Peschon Jacques J; Castner Beverly J; Gerhart Mary J; Paxton Raymond J; Black Roy A; Lee David C
Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability.
The Journal of biological chemistry 2002;277(15):12838-45.
2002: Guo Lin; Eisenman June R; Mahimkar Rajeev M; Peschon Jacques J; Paxton Raymond J; Black Roy A; Johnson Richard S
A proteomic approach for the identification of cell-surface proteins shed by metalloproteases.
Molecular & cellular proteomics : MCP 2002;1(1):30-6.
2002: Black Roy A
Tumor necrosis factor-alpha converting enzyme.
The international journal of biochemistry & cell biology 2002;34(1):1-5.
2001: Levin J I; Chen J M; Du M T; Nelson F C; Wehr T; DiJoseph J F; Killar L M; Skala S; Sung A; Sharr M A; Roth C E; Jin G; Cowling R; Di L; Sherman M; Xu Z B; March C J; Mohler K M; Black R A; Skotnicki J S
The discovery of anthranilic acid-based MMP inhibitors. Part 3: incorporation of basic amines.
Bioorganic & medicinal chemistry letters 2001;11(22):2975-8.
2001: Levin J I; Chen J; Du M; Hogan M; Kincaid S; Nelson F C; Venkatesan A M; Wehr T; Zask A; DiJoseph J; Killar L M; Skala S; Sung A; Sharr M; Roth C; Jin G; Cowling R; Mohler K M; Black R A; March C J; Skotnicki J S
The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups.
Bioorganic & medicinal chemistry letters 2001;11(16):2189-92.
2001: Zhang Y; Guan R; Jiang J; Kopchick J J; Black R A; Baumann G; Frank S J
Growth hormone (GH)-induced dimerization inhibits phorbol ester-stimulated GH receptor proteolysis.
The Journal of biological chemistry 2001;276(27):24565-73.
2001: Guan R; Zhang Y; Jiang J; Baumann C A; Black R A; Baumann G; Frank S J
Phorbol ester- and growth factor-induced growth hormone (GH) receptor proteolysis and GH-binding protein shedding: relationship to GH receptor down-regulation.
Endocrinology 2001;142(3):1137-47.
2000: Zhang Y; Jiang J; Black R A; Baumann G; Frank S J
Tumor necrosis factor-alpha converting enzyme (TACE) is a growth hormone binding protein (GHBP) sheddase: the metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor proteolysis and GHBP generation.
Endocrinology 2000;141(12):4342-8.
2000: Frank S J; Messina J L; Baumann G; Black R A; Bertics P J
Insights into modulation of (and by) growth hormone signaling.
The Journal of laboratory and clinical medicine 2000;136(1):14-20.
2000: Reddy P; Slack J L; Davis R; Cerretti D P; Kozlosky C J; Blanton R A; Shows D; Peschon J J; Black R A
Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme.
The Journal of biological chemistry 2000;275(19):14608-14.
2000: Doedens J R; Black R A
Stimulation-induced down-regulation of tumor necrosis factor-alpha converting enzyme.
The Journal of biological chemistry 2000;275(19):14598-607.
2000: Brou C; Logeat F; Gupta N; Bessia C; LeBail O; Doedens J R; Cumano A; Roux P; Black R A; Israël A
A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE.
Molecular cell 2000;5(2):207-16.
1999: Cerretti D P; DuBose R F; Black R A; Nelson N
Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show testis-specific gene expression.
Biochemical and biophysical research communications 1999;263(3):810-5.
1999: Poindexter K; Nelson N; DuBose R F; Black R A; Cerretti D P
The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries.
Gene 1999;237(1):61-70.
1999: Cerretti D P; Poindexter K; Castner B J; Means G; Copeland N G; Gilbert D J; Jenkins N A; Black R A; Nelson N
Characterization of the cDNA and gene for mouse tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and its location to mouse chromosome 12 and human chromosome 2p25.
Cytokine 1999;11(8):541-51.
1998: Peschon J J; Slack J L; Reddy P; Stocking K L; Sunnarborg S W; Lee D C; Russell W E; Castner B J; Johnson R S; Fitzner J N; Boyce R W; Nelson N; Kozlosky C J; Wolfson M F; Rauch C T; Cerretti D P; Paxton R J; March C J; Black R A
An essential role for ectodomain shedding in mammalian development.
Science (New York, N.Y.) 1998;282(5392):1281-4.
1998: Black R A; White J M
ADAMs: focus on the protease domain.
Current opinion in cell biology 1998;10(5):654-9.
1998: Buxbaum J D; Liu K N; Luo Y; Slack J L; Stocking K L; Peschon J J; Johnson R S; Castner B J; Cerretti D P; Black R A
Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor.
The Journal of biological chemistry 1998;273(43):27765-7.
1998: Clarke H R; Wolfson M F; Rauch C T; Castner B J; Huang C P; Gerhart M J; Johnson R S; Cerretti D P; Paxton R J; Price V L; Black R A
Expression and purification of correctly processed, active human TACE catalytic domain in Saccharomyces cerevisiae.
Protein expression and purification 1998;13(1):104-10.
1998: Alele J; Jiang J; Goldsmith J F; Yang X; Maheshwari H G; Black R A; Baumann G; Frank S J
Blockade of growth hormone receptor shedding by a metalloprotease inhibitor.
Endocrinology 1998;139(4):1927-35.
1998: Maskos K; Fernandez-Catalan C; Huber R; Bourenkov G P; Bartunik H; Ellestad G A; Reddy P; Wolfson M F; Rauch C T; Castner B J; Davis R; Clarke H R; Petersen M; Fitzner J N; Cerretti D P; March C J; Paxton R J; Black R A; Bode W
Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3408-12.
1997: Black R A; Rauch C T; Kozlosky C J; Peschon J J; Slack J L; Wolfson M F; Castner B J; Stocking K L; Reddy P; Srinivasan S; Nelson N; Boiani N; Schooley K A; Gerhart M; Davis R; Fitzner J N; Johnson R S; Paxton R J; March C J; Cerretti D P
A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells.
Nature 1997;385(6618):729-33.
1997: Müllberg J; Rauch C T; Wolfson M F; Castner B; Fitzner J N; Otten-Evans C; Mohler K M; Cosman D; Black R A
Further evidence for a common mechanism for shedding of cell surface proteins.
FEBS letters 1997;401(2-3):235-8.
1996: Black R A; Durie F H; Otten-Evans C; Miller R; Slack J L; Lynch D H; Castner B; Mohler K M; Gerhart M; Johnson R S; Itoh Y; Okada Y; Nagase H
Relaxed specificity of matrix metalloproteinases (MMPS) and TIMP insensitivity of tumor necrosis factor-alpha (TNF-alpha) production suggest the major TNF-alpha converting enzyme is not an MMP.
Biochemical and biophysical research communications 1996;225(2):400-5.
1995: Estrov Z; Black R A; Sleath P R; Harris D; Van Q; LaPushin R; Estey E H; Talpaz M
Effect of interleukin-1 beta converting enzyme inhibitor on acute myelogenous leukemia progenitor proliferation.
Blood 1995;86(12):4594-602.
1995: Müllberg J; Durie F H; Otten-Evans C; Alderson M R; Rose-John S; Cosman D; Black R A; Mohler K M
A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(11):5198-205.
1995: Crowe P D; Walter B N; Mohler K M; Otten-Evans C; Black R A; Ware C F
A metalloprotease inhibitor blocks shedding of the 80-kD TNF receptor and TNF processing in T lymphocytes.
The Journal of experimental medicine 1995;181(3):1205-10.
1992: Kronheim S R; Mumma A; Greenstreet T; Glackin P J; Van Ness K; March C J; Black R A
Purification of interleukin-1 beta converting enzyme, the protease that cleaves the interleukin-1 beta precursor.
Archives of biochemistry and biophysics 1992;296(2):698-703.
1992: Ray C A; Black R A; Kronheim S R; Greenstreet T A; Sleath P R; Salvesen G S; Pickup D J
Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme.
Cell 1992;69(4):597-604.
1990: Sleath P R; Hendrickson R C; Kronheim S R; March C J; Black R A
Substrate specificity of the protease that processes human interleukin-1 beta.
The Journal of biological chemistry 1990;265(24):14526-8.
1989: Black R A; Kronheim S R; Merriam J E; March C J; Hopp T P
A pre-aspartate-specific protease from human leukocytes that cleaves pro-interleukin-1 beta.
The Journal of biological chemistry 1989;264(10):5323-6.
1989: Black R A; Kronheim S R; Sleath P R
Activation of interleukin-1 beta by a co-induced protease.
FEBS letters 1989;247(2):386-90.
1988: Black R A; Kronheim S R; Cantrell M; Deeley M C; March C J; Prickett K S; Wignall J; Conlon P J; Cosman D; Hopp T P
Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor.
The Journal of biological chemistry 1988;263(19):9437-42.

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