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George Scheffer

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Chemicals & Drugs

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Sue Ellen Verbrugge; Sonja Zweegman; Marjon Al; Janet L Anderl; Yehuda G Assaraf; Elena T Chan; Jacqueline Cloos; Tanja D de Gruijl; Ben Ac Dijkmans; Christopher J Kirk; Willem F Lems; Denise Niewerth; Godefridus J Peters; George L Scheffer; Rik J Scheper; Michael van der Veer; Johan van Meerloo; Gerrit Jansen
Overcoming bortezomib resistance in human B cells by anti-CD20/rituximab-mediated complement-dependent cytotoxicity and epoxyketone-based irreversible proteasome inhibitors.
A van Dijk; Florine J van Milligen; A C van Rossum; Ruud Oerlemans; George L Scheffer; Gerrit J Schuurhuis; J Aznou; M Brouwer; W J F M Jurgens; J Kassies; B A Naaijkens; H W M Niessen
The multidrug resistance protein breast cancer resistance protein (BCRP) protects adipose-derived stem cells against ischemic damage.
Sue Ellen Verbrugge; Marjon Al; Yehuda G Assaraf; Elena T Chan; Tanja D de Gruijl; Debby den Uyl; Ben A C Dijkmans; Christopher J Kirk; Ruud Oerlemans; Godefridus J Peters; George L Scheffer; Rik J Scheper; Joost van der Heijden; Gerrit Jansen
Inactivating PSMB5 mutations and P-glycoprotein (multidrug resistance-associated protein/ATP-binding cassette B1) mediate resistance to proteasome inhibitors: ex vivo efficacy of (immuno)proteasome inhibitors in mononuclear blood cells from patients with rheumatoid arthritis.

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All Publications

2013: Sue Ellen Verbrugge; Sonja Zweegman; Marjon Al; Janet L Anderl; Yehuda G Assaraf; Elena T Chan; Jacqueline Cloos; Tanja D de Gruijl; Ben Ac Dijkmans; Christopher J Kirk; Willem F Lems; Denise Niewerth; Godefridus J Peters; George L Scheffer; Rik J Scheper; Michael van der Veer; Johan van Meerloo; Gerrit Jansen
Overcoming bortezomib resistance in human B cells by anti-CD20/rituximab-mediated complement-dependent cytotoxicity and epoxyketone-based irreversible proteasome inhibitors.
Experimental hematology & oncology 2013;2(1):2.
2012: A van Dijk; Florine J van Milligen; A C van Rossum; Ruud Oerlemans; George L Scheffer; Gerrit J Schuurhuis; J Aznou; M Brouwer; W J F M Jurgens; J Kassies; B A Naaijkens; H W M Niessen
The multidrug resistance protein breast cancer resistance protein (BCRP) protects adipose-derived stem cells against ischemic damage.
Cell biology and toxicology 2012;28(5):303-15.
2012: Sue Ellen Verbrugge; Marjon Al; Yehuda G Assaraf; Elena T Chan; Tanja D de Gruijl; Debby den Uyl; Ben A C Dijkmans; Christopher J Kirk; Ruud Oerlemans; Godefridus J Peters; George L Scheffer; Rik J Scheper; Joost van der Heijden; Gerrit Jansen
Inactivating PSMB5 mutations and P-glycoprotein (multidrug resistance-associated protein/ATP-binding cassette B1) mediate resistance to proteasome inhibitors: ex vivo efficacy of (immuno)proteasome inhibitors in mononuclear blood cells from patients with rheumatoid arthritis.
The Journal of pharmacology and experimental therapeutics 2012;341(1):174-82.
2012: Rieneke van de Ven; Sandra van Wetering; Pepijn G J T B Wijnands; Erik Hooijberg; Ada M Kruisbeek; Anneke W Reurs; George L Scheffer; Rik J Scheper; Tanja D de Gruijl
Exposure of CD34+ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy.
Cancer immunology, immunotherapy : CII 2012;61(2):181-91.
2012: Rieneke van de Ven; Jelle J Lindenberg; Anneke W Reurs; George L Scheffer; Rik J Scheper; Tanja D de Gruijl
Preferential Langerhans cell differentiation from CD34(+) precursors upon introduction of ABCG2 (BCRP).
Immunology and cell biology 2012;90(2):206-15.
2011: Rieneke van de Ven; Sue Ellen Verbrugge; Hetty J Bontkes; Erik Hooijberg; Gerrit Jansen; Anneke W Reurs; George L Scheffer; Rik J Scheper; Tanja D de Gruijl
High susceptibility of c-KIT+CD34+ precursors to prolonged doxorubicin exposure interferes with Langerhans cell differentiation in a human cell line model.
Cancer immunology, immunotherapy : CII 2011;60(7):943-51.
2011: Clara Lemos; Elisa Giovannetti; Paolo A Zucali; Yehuda G Assaraf; George L Scheffer; Tahar van der Straaten; Armida D'Incecco; Alfredo Falcone; Henk-Jan Guchelaar; Romano Danesi; Armando Santoro; Giuseppe Giaccone; Carmelo Tibaldi; Godefridus J Peters
Impact of ABCG2 polymorphisms on the clinical outcome and toxicity of gefitinib in non-small-cell lung cancer patients.
Pharmacogenomics 2011;12(2):159-70.
2010: Wouter F W Bierman; George L Scheffer; Antoinet Schoonderwoerd; Gerrit Jansen; Michiel A van Agtmael; Sven A Danner; Rik J Scheper
Protease inhibitors atazanavir, lopinavir and ritonavir are potent blockers, but poor substrates, of ABC transporters in a broad panel of ABC transporter-overexpressing cell lines.
The Journal of antimicrobial chemotherapy 2010;65(8):1672-80.
2009: Rieneke van de Ven; Jelle J Lindenberg; Dinja Oosterhoff; M Petrousjka van den Tol; Rodney A Rosalia; Miho Murakami; Maaike Everts; George L Scheffer; Rik J Scheper; Tanja D de Gruijl; David T Curiel
Selective transduction of mature DC in human skin and lymph nodes by CD80/CD86-targeted fiber-modified adenovirus-5/3.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2009;32(9):895-906.
2009: Rieneke van de Ven; Ruud Oerlemans; Joost W van der Heijden; George L Scheffer; Tanja D de Gruijl; Gerrit Jansen; Rik J Scheper
ABC drug transporters and immunity: novel therapeutic targets in autoimmunity and cancer.
Journal of leukocyte biology 2009;86(5):1075-87.
2009: Rieneke van de Ven; George L Scheffer; Rik J Scheper; Tanja D de Gruijl
The ABC of dendritic cell development and function.
Trends in immunology 2009;30(9):421-9.
2009: Rieneke van de Ven; Jan de Groot; Anneke W Reurs; Pepijn G J T B Wijnands; Koen van de Wetering; John D Schuetz; Tanja D de Gruijl; Rik J Scheper; George L Scheffer
Unimpaired immune functions in the absence of Mrp4 (Abcc4).
Immunology letters 2009;124(2):81-7.
2009: Joost van der Heijden; Ruud Oerlemans; Paul P Tak; Yehuda G Assaraf; Maarten C Kraan; George L Scheffer; Conny J van der Laken; Willem F Lems; Rik J Scheper; Ben A C Dijkmans; Gerrit Jansen
Involvement of breast cancer resistance protein expression on rheumatoid arthritis synovial tissue macrophages in resistance to methotrexate and leflunomide.
Arthritis and rheumatism 2009;60(3):669-77.
2009: Clara Lemos; Ietje Kathmann; Elisa Giovannetti; Jeroen A M Beliën; George L Scheffer; Conceição Calhau; Gerrit Jansen; Godefridus J Peters
Cellular folate status modulates the expression of BCRP and MRP multidrug transporters in cancer cell lines from different origins.
Molecular cancer therapeutics 2009;8(3):655-64.
2008: Clara Lemos; Ietje Kathmann; Elisa Giovannetti; Henk Dekker; George L Scheffer; Conceição Calhau; Gerrit Jansen; Godefridus J Peters
Folate deprivation induces BCRP (ABCG2) expression and mitoxantrone resistance in Caco-2 cells.
International journal of cancer. Journal international du cancer 2008;123(7):1712-20.
2008: Rieneke van de Ven; George L Scheffer; Anneke W Reurs; Jelle J Lindenberg; Ruud Oerlemans; Gerrit Jansen; Jean-Pierre Gillet; Joel N Glasgow; Alexander Pereboev; David T Curiel; Rik J Scheper; Tanja D de Gruijl
A role for multidrug resistance protein 4 (MRP4; ABCC4) in human dendritic cell migration.
Blood 2008;112(6):2353-9.
2007: Nobuhito Ono; Ingrid van der Heijden; George L Scheffer; Koen van de Wetering; Elizabeth Van Deemter; Marcel de Haas; Arjan Boerke; Bart M Gadella; Dirk G De Rooij; Jacques Neefjes; Tom A M Groothuis; Lauran Oomen; Lenny Brocks; Toshihisa Ishikawa; Piet Borst
Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm.
The Biochemical journal 2007;406(1):31-40.
2007: Kazumasa Takenaka; Jessica A Morgan; George L Scheffer; Masashi Adachi; Clinton F Stewart; Daxi Sun; Markos Leggas; Karin F K Ejendal; Christine A Hrycyna; John D Schuetz
Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution.
Cancer research 2007;67(14):6965-72.
2007: Cornelia J F De Wolf; Hiroaki Yamaguchi; Ingrid van der Heijden; peter wielinga; Stefanie L Hundscheid; Nobuhito Ono; George L Scheffer; Marcel de Haas; John D Schuetz; Jan Wijnholds; Piet Borst
cGMP transport by vesicles from human and mouse erythrocytes.
The FEBS journal 2007;274(2):439-50.
2007: Pauline Breedveld; Dick Pluim; Greta Cipriani; Femke Dahlhaus; Monique van Eijndhoven; Cornelia J F De Wolf; Annemieke Kuil; Jos H Beijnen; George L Scheffer; Gerrit Jansen; Piet Borst; Jan H M Schellens
The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models.
Molecular pharmacology 2007;71(1):240-9.
2006: Rieneke van de Ven; Mariska C de Jong; Anneke W Reurs; Antoinet J N Schoonderwoerd; Gerrit Jansen; Jan Hendrik Hooijberg; George L Scheffer; Tanja D de Gruijl; Rik J Scheper
Dendritic cells require multidrug resistance protein 1 (ABCC1) transporter activity for differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5191-8.
2006: Noam Zelcer; Koen van de Wetering; Rudi de Waart; George L Scheffer; Hanns-Ulrich Marschall; peter wielinga; Annemieke Kuil; Cindy Kunne; Alexander Smith; Martin van der Valk; Jan Wijnholds; Ronald Oude Elferink; Piet Borst
Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides.
Journal of hepatology 2006;44(4):768-75.
2006: Ruud Oerlemans; Joost van der Heijden; Jacqueline M Vink; B A C Dijkmans; G J L Kaspers; Willem F Lems; George L Scheffer; Ilan Ifergan; Rik J Scheper; Jacqueline Cloos; Yehuda G Assaraf; Gerrit Jansen
Acquired resistance to chloroquine in human CEM T cells is mediated by multidrug resistance-associated protein 1 and provokes high levels of cross-resistance to glucocorticoids.
Arthritis and rheumatism 2006;54(2):557-68.
2006: Arend van Zon; Marieke H Mossink; Adriaan B Houtsmuller; Martijn Schoester; George L Scheffer; Rik J Scheper; Pieter Sonneveld; Erik A C Wiemer
Vault mobility depends in part on microtubules and vaults can be recruited to the nuclear envelope.
Experimental cell research 2006;312(3):245-55.
2005: Ilan Ifergan; George L Scheffer; Yehuda G Assaraf
Novel extracellular vesicles mediate an ABCG2-dependent anticancer drug sequestration and resistance.
Cancer research 2005;65(23):10952-8.
2005: Theo G M F Gorgels; Xiaofeng Hu; George L Scheffer; Allard C van der Wal; Johan Toonstra; Paulus T V M de Jong; Toin H van Kuppevelt; Christiaan N Levelt; Anneke de Wolf; Willem J P Loves; Rik J Scheper; Ron Peek; Arthur A B Bergen
Disruption of Abcc6 in the mouse: novel insight in the pathogenesis of pseudoxanthoma elasticum.
Human molecular genetics 2005;14(13):1763-73.
2005: Murray D Norris; Janice Smith; Kara Tanabe; Peter J Tobin; Claudia Flemming; George L Scheffer; peter wielinga; Susan Cohn; Wendy B London; Glenn M Marshall; John D Allen; Michelle Haber
Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro.
Molecular cancer therapeutics 2005;4(4):547-53.
2005: Astrid E Greijer; Mariska C de Jong; George L Scheffer; Avi Shvarts; Paulus van Diest; ELSKEN VAN DER WALL
Hypoxia-induced acidification causes mitoxantrone resistance not mediated by drug transporters in human breast cancer cells.
Cellular oncology : the official journal of the International Society for Cellular Oncology 2005;27(1):43-9.
2004: Markos Leggas; Masashi Adachi; George L Scheffer; Daxi Sun; peter wielinga; Guoqing Du; Kelly E Mercer; Yanli Zhuang; John C Panetta; Brad Johnston; Rik J Scheper; Clinton F Stewart; John D Schuetz
Mrp4 confers resistance to topotecan and protects the brain from chemotherapy.
Molecular and cellular biology 2004;24(17):7612-21.
2004: Ilan Ifergan; Assaf Shafran; Gerrit Jansen; Jan Hendrik Hooijberg; George L Scheffer; Yehuda G Assaraf
Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression. A role for BCRP in cellular folate homeostasis.
The Journal of biological chemistry 2004;279(24):25527-34.
2004: Joost van der Heijden; Mariska C de Jong; B A C Dijkmans; Willem F Lems; Ruud Oerlemans; Ietje Kathmann; C G Schalkwijk; George L Scheffer; Rik J Scheper; Gerrit Jansen
Development of sulfasalazine resistance in human T cells induces expression of the multidrug resistance transporter ABCG2 (BCRP) and augmented production of TNFalpha.
Annals of the rheumatic diseases 2004;63(2):138-43.
2004: Joost van der Heijden; Mariska C de Jong; B A C Dijkmans; Willem F Lems; Ruud Oerlemans; Ietje Kathmann; George L Scheffer; Rik J Scheper; Yehuda G Assaraf; Gerrit Jansen
Acquired resistance of human T cells to sulfasalazine: stability of the resistant phenotype and sensitivity to non-related DMARDs.
Annals of the rheumatic diseases 2004;63(2):131-7.
2003: Sabine L A Plasschaert; Dorina M van der Kolk; Eveline S J M de Bont; Willem A Kamps; Kuniaki Morisaki; Susan E Bates; George L Scheffer; Rik J Scheper; Edo Vellenga; Elisabeth G E de Vries
The role of breast cancer resistance protein in acute lymphoblastic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(14):5171-7.
2003: Arend van Zon; Marieke H Mossink; Martijn Schoester; Adriaan B Houtsmuller; George L Scheffer; Rik J Scheper; Pieter Sonneveld; Erik A C Wiemer
The formation of vault-tubes: a dynamic interaction between vaults and vault PARP.
Journal of cell science 2003;116(Pt 21):4391-400.
2003: Mariska C de Jong; George L Scheffer; Henk J Broxterman; Jan Hendrik Hooijberg; Jerry W Slootstra; Rob H Meloen; Robert J Kreitman; Syed R Husain; Bharat H Joshi; Raj K Puri; Rik J Scheper
Multidrug-resistant tumor cells remain sensitive to a recombinant interleukin-4-Pseudomonas exotoxin, except when overexpressing the multidrug resistance protein MRP1.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(13):5009-17.
2003: Julio E Diestra; Enric Condom; Xavier García Del Muro; George L Scheffer; Javier Pérez; Amado J Zurita; José Muñoz-Seguí; Francisco Vigués; Rik J Scheper; Gabriel Capellá; Josep Ramón Germà-Lluch; Miguel A Izquierdo
Expression of multidrug resistance proteins P-glycoprotein, multidrug resistance protein 1, breast cancer resistance protein and lung resistance related protein in locally advanced bladder cancer treated with neoadjuvant chemotherapy: biological and clinical implications.
The Journal of urology 2003;170(4 Pt 1):1383-7.
2003: Marieke H Mossink; Jan de Groot; Arend van Zon; Erna Fränzel-Luiten; Martijn Schoester; George L Scheffer; Pieter Sonneveld; Rik J Scheper; Erik A C Wiemer
Unimpaired dendritic cell functions in MVP/LRP knockout mice.
Immunology 2003;110(1):58-65.
2003: Michal Stark; Lilah Rothem; Gerrit Jansen; George L Scheffer; I David Goldman; Yehuda G Assaraf
Antifolate resistance associated with loss of MRP1 expression and function in Chinese hamster ovary cells with markedly impaired export of folate and cholate.
Molecular pharmacology 2003;64(2):220-7.
2003: Amado J Zurita; Julio E Diestra; Enric Condom; Xavier García del Muro; George L Scheffer; Rik J Scheper; J Pérez; Josep Ramón Germà-Lluch; Miguel A Izquierdo
Lung resistance-related protein as a predictor of clinical outcome in advanced testicular germ-cell tumours.
British journal of cancer 2003;88(6):879-86.
2003: Jan Hendrik Hooijberg; Godefridus J Peters; Yehuda G Assaraf; Ietje Kathmann; David G Priest; Marlene A Bunni; Anjo J P Veerman; George L Scheffer; G J L Kaspers; Gerrit Jansen
The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis.
Biochemical pharmacology 2003;65(5):765-71.
2003: Marjolein A van der Pol; Henk J Broxterman; Jennie M Pater; Nicole Feller; Martin van der Maas; G W D Weijers; George L Scheffer; John D Allen; Rik J Scheper; Arnold van Loevezijn; Gert Ossenkoppele; Gerrit J Schuurhuis
Function of the ABC transporters, P-glycoprotein, multidrug resistance protein and breast cancer resistance protein, in minimal residual disease in acute myeloid leukemia.
Haematologica 2003;88(2):134-47.
2003: Frank Mayer; hans stoop; George L Scheffer; Rik J Scheper; J Wolter Oosterhuis; Leendert H J Looijenga; Carsten Bokemeyer
Molecular determinants of treatment response in human germ cell tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(2):767-73.
2002: Marieke H Mossink; Arend van Zon; Erna Fränzel-Luiten; Martijn Schoester; Valerie A Kickhoefer; George L Scheffer; Rik J Scheper; Pieter Sonneveld; Erik A C Wiemer
Disruption of the murine major vault protein (MVP/LRP) gene does not induce hypersensitivity to cytostatics.
Cancer research 2002;62(24):7298-304.
2002: johan jonker; Marije Buitelaar; Els Wagenaar; Martin van der Valk; George L Scheffer; Rik J Scheper; Torsten Plosch; Folkert Kuipers; Ronald P J Oude Elferink; Hilde Rosing; Jos H Beijnen; Alfred H Schinkel
The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15649-54.
2002: Julio E Diestra; George L Scheffer; Isabel Català; Marc Maliepaard; Jan H M Schellens; Rik J Scheper; Josep Ramón Germà-Lluch; Miguel A Izquierdo
Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material.
The Journal of pathology 2002;198(2):213-9.
2002: Annemarie H Van Hattum; I J Hoogsteen; Hennie M M Schlüper; Marc Maliepaard; George L Scheffer; Rik J Scheper; G Kohlhagen; Y Pommier; HERBERT PINEDO; Epie Boven
Induction of breast cancer resistance protein by the camptothecin derivative DX-8951f is associated with minor reduction of antitumour activity.
British journal of cancer 2002;87(6):665-72.
2002: Marieke H Mossink; Arend van Zon; Erna Fränzel-Luiten; Martijn Schoester; George L Scheffer; Rik J Scheper; Pieter Sonneveld; Erik A C Wiemer
The genomic sequence of the murine major vault protein and its promoter.
Gene 2002;294(1-2):225-32.
2002: George L Scheffer; Marcel J Flens; Sandra Hageman; Miguel A Izquierdo; Robert H Shoemaker; Rik J Scheper
Expression of the vascular endothelial cell protein C receptor in epithelial tumour cells.
European journal of cancer (Oxford, England : 1990) 2002;38(11):1535-42.
2002: George L Scheffer; M C de Jong; Anne Monks; Marcel J Flens; Curtis Hose; Miguel A Izquierdo; Robert H Shoemaker; Rik J Scheper
Increased expression of beta 2-microglobulin in multidrug-resistant tumour cells.
British journal of cancer 2002;86(12):1943-50.
2002: Dorina M van der Kolk; Edo Vellenga; George L Scheffer; Michael Müller; Susan E Bates; Rik J Scheper; Elisabeth G E de Vries
Expression and activity of breast cancer resistance protein (BCRP) in de novo and relapsed acute myeloid leukemia.
Blood 2002;99(10):3763-70.
2002: George L Scheffer; Adriana C L M Pijnenborg; E F Smit; Michael Müller; D S Postma; Wim Timens; Paul Van Der Valk; E G E de Vries; Rik J Scheper
Multidrug resistance related molecules in human and murine lung.
Journal of clinical pathology 2002;55(5):332-9.
2002: George L Scheffer; Xiaofeng Hu; Adriana C L M Pijnenborg; Jan Wijnholds; Arthur A B Bergen; Rik J Scheper
MRP6 (ABCC6) detection in normal human tissues and tumors.
Laboratory investigation; a journal of technical methods and pathology 2002;82(4):515-8.
2002: Ian F Faneyte; Petra M P Kristel; Marc Maliepaard; George L Scheffer; Rik J Scheper; Jan H M Schellens; Marc J van de Vijver
Expression of the breast cancer resistance protein in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(4):1068-74.
2002: George L Scheffer; Anneke W Reurs; B Jutten; S H W Beiboer; R van Amerongen; Martijn Schoester; Erik A C Wiemer; Hennie Hoogenboom; Rik J Scheper
Selection and characterisation of a phage-displayed human antibody (Fab) reactive to the lung resistance-related major vault protein.
British journal of cancer 2002;86(6):954-62.
2002: Arend van Zon; Marieke H Mossink; Martijn Schoester; George L Scheffer; Rik J Scheper; Pieter Sonneveld; Erik A C Wiemer
Structural domains of vault proteins: a role for the coiled coil domain in vault assembly.
Biochemical and biophysical research communications 2002;291(3):535-41.
2002: Anouk B Schroeijers; Anneke W Reurs; George L Scheffer; Anita G M Stam; Mariska C de Jong; Thomas Rustemeyer; Erik A C Wiemer; Tanja D de Gruijl; Rik J Scheper
Up-regulation of drug resistance-related vaults during dendritic cell development.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1572-8.
2002: George L Scheffer; Marcel Kool; Marcel de Haas; J Marleen L de Vree; Adriana C L M Pijnenborg; Diederik K Bosman; Ronald P J Oude Elferink; Paul Van Der Valk; Piet Borst; Rik J Scheper
Tissue distribution and induction of human multidrug resistant protein 3.
Laboratory investigation; a journal of technical methods and pathology 2002;82(2):193-201.
2002: Mariël Brinkhuis; Miguel A Izquierdo; Jan P A Baak; Paulus van Diest; Peter Kenemans; George L Scheffer; Rik J Scheper
Expression of multidrug resistance-associated markers, their relation to quantitative pathologic tumour characteristics and prognosis in advanced ovarian cancer.
Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology 2002;24(1):17-23.
2002: George L Scheffer; Rik J Scheper
Drug resistance molecules: lessons from oncology.
Novartis Foundation symposium 2002;243():19-31; discussion 31-7, 180-5.
2001: Anouk B Schroeijers; George L Scheffer; Anneke W Reurs; Adriana C L M Pijnenborg; C Abbondanza; Erik A C Wiemer; Rik J Scheper
Detection of the Mr 110,000 lung resistance-related protein LRP/MVP with monoclonal antibodies.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2001;49(11):1379-85.
2001: Arend van Zon; Marieke H Mossink; Martijn Schoester; George L Scheffer; Rik J Scheper; Pieter Sonneveld; Erik A C Wiemer
Multiple human vault RNAs. Expression and association with the vault complex.
The Journal of biological chemistry 2001;276(40):37715-21.
2001: Marc Maliepaard; George L Scheffer; Ian F Faneyte; Margôt van Gastelen; Adriana C L M Pijnenborg; Alfred H Schinkel; Marc J van de Vijver; Rik J Scheper; J H M Schellens
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.
Cancer research 2001;61(8):3458-64.
2001: Mariska C de Jong; Jerry W Slootstra; George L Scheffer; Anouk B Schroeijers; Wouter C Puijk; R Dinkelberg; Marcel Kool; Henk J Broxterman; Rob H Meloen; Rik J Scheper
Peptide transport by the multidrug resistance protein MRP1.
Cancer research 2001;61(6):2552-7.
2001: Bellinda A Bladergroen; Merel C M Strik; N Bovenschen; O van Berkum; George L Scheffer; Chris J L M Meijer; C Erik Hack; J Alain Kummer
The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3218-25.
2001: Charles Erlichman; Scott A Boerner; C G Hallgren; R Spieker; X Y Wang; C David James; George L Scheffer; Marc Maliepaard; Douglas Ross; Keith C Bible; Scott H Kaufmann
The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux.
Cancer research 2001;61(2):739-48.
2000: George L Scheffer; Anouk B Schroeijers; Miguel A Izquierdo; Erik A C Wiemer; Rik J Scheper
Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer.
Current opinion in oncology 2000;12(6):550-6.
2000: George L Scheffer; Marcel Kool; Marc Heijn; Marcel de Haas; Adriana C L M Pijnenborg; Jan Wijnholds; Ardy van Helvoort; Mariska C de Jong; Jan Hendrik Hooijberg; CA Mol; M van der Linden; J Marleen L de Vree; Paul Van Der Valk; Ronald P J Oude Elferink; Piet Borst; Rik J Scheper
Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies.
Cancer research 2000;60(18):5269-77.
2000: Jan Wijnholds; CA Mol; Liesbeth Van Deemter; Marcel de Haas; George L Scheffer; F Baas; Jos H Beijnen; Rik J Scheper; S Hatse; E De Clercq; Jan Balzarini; Piet Borst
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7476-81.
2000: George L Scheffer; Marc Maliepaard; Adriana C L M Pijnenborg; Margôt van Gastelen; Mariska C de Jong; Anouk B Schroeijers; Dorina M van der Kolk; J D Allen; Douglas Ross; Paul Van Der Valk; W S Dalton; J H M Schellens; Rik J Scheper
Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines.
Cancer research 2000;60(10):2589-93.
2000: Anouk B Schroeijers; AC Siva; George L Scheffer; Mariska C de Jong; S C Bolick; Danny F Dukers; Jerry W Slootstra; Rob H Meloen; Erik A C Wiemer; Valerie A Kickhoefer; Leonard H Rome; Rik J Scheper
The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines.
Cancer research 2000;60(4):1104-10.
2000: Jan Wijnholds; E C deLange; George L Scheffer; D J van den Berg; CA Mol; Martin van der Valk; Alfred H Schinkel; Rik J Scheper; Douwe D Breimer; Piet Borst
Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier.
The Journal of clinical investigation 2000;105(3):279-85.
2000: J H M Schellens; Marc Maliepaard; Rik J Scheper; George L Scheffer; johan jonker; Johan W Smit; Jos H Beijnen; Alfred H Schinkel
Transport of topoisomerase I inhibitors by the breast cancer resistance protein. Potential clinical implications.
Annals of the New York Academy of Sciences 2000;922():188-94.
1999: H J G Arts; Dionyssios Katsaros; Elisabeth G E de Vries; Marco Massobrio; Franco Genta; Saverio Danese; RICCARDO ARISIO; Rik J Scheper; Marcel Kool; George L Scheffer; P H B Willemse; Ate G J van der Zee; Albert J H Suurmeijer
Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(10):2798-805.
1999: Jan Hendrik Hooijberg; Henk J Broxterman; George L Scheffer; C Vrasdonk; Marc Heijn; Mariska C de Jong; Rik J Scheper; Jan Lankelma; HERBERT PINEDO
Potent interaction of flavopiridol with MRP1.
British journal of cancer 1999;81(2):269-76.
1999: Marcel Kool; M van der Linden; Marcel de Haas; George L Scheffer; J Marleen L de Vree; AJ Smith; Gerrit Jansen; Godefridus J Peters; N Ponne; Rik J Scheper; Ronald P J Oude Elferink; F Baas; Piet Borst
MRP3, an organic anion transporter able to transport anti-cancer drugs.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6914-9.
1999: Christian W van Haselen; Marcel J Flens; Rik J Scheper; Paul Van Der Valk; George L Scheffer; Johan Toonstra; Willem A van Vloten
Multidrug resistance related proteins in primary cutaneous lymphomas.
Advances in experimental medicine and biology 1999;457():119-31.
1998: Valerie A Kickhoefer; K S Rajavel; George L Scheffer; W S Dalton; R J Scheper; Leonard H Rome
Vaults are up-regulated in multidrug-resistant cancer cell lines.
The Journal of biological chemistry 1998;273(15):8971-4.
1998: Anouk B Schroeijers; George L Scheffer; Marcel J Flens; Gerrit A Meijer; Miguel A Izquierdo; Paul Van Der Valk; Rik J Scheper
Immunohistochemical detection of the human major vault protein LRP with two monoclonal antibodies in formalin-fixed, paraffin-embedded tissues.
The American journal of pathology 1998;152(2):373-8.
1997: Marcel J Flens; George L Scheffer; Paul Van Der Valk; H J Broxterman; E W Eijdems; A C Huysmans; Miguel A Izquierdo; Rik J Scheper
Identification of novel drug resistance-associated proteins by a panel of rat monoclonal antibodies.
International journal of cancer. Journal international du cancer 1997;73(2):249-57.
1997: Marcel Kool; Marcel de Haas; George L Scheffer; Rik J Scheper; M J van Eijk; Jenneke A Juijn; F Baas; Piet Borst
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.
Cancer research 1997;57(16):3537-47.
1997: Coen C Paulusma; Marcel Kool; Piter J Bosma; George L Scheffer; F ter Borg; Rik J Scheper; G N J Tytgat; Piet Borst; F Baas; Ronald P J Oude Elferink
A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome.
Hepatology (Baltimore, Md.) 1997;25(6):1539-42.
1997: Marc Heijn; Jan Hendrik Hooijberg; George L Scheffer; G Szabó; Hans V Westerhoff; Jan Lankelma
Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport.
Biochimica et biophysica acta 1997;1326(1):12-22.
1996: Miguel A Izquierdo; J J Neefjes; A E Mathari; Marcel J Flens; George L Scheffer; Rik J Scheper
Overexpression of the ABC transporter TAP in multidrug-resistant human cancer cell lines.
British journal of cancer 1996;74(12):1961-7.
1996: Miguel A Izquierdo; George L Scheffer; Marcel J Flens; Anouk B Schroeijers; Paul Van Der Valk; Rik J Scheper
Major vault protein LRP-related multidrug resistance.
European journal of cancer (Oxford, England : 1990) 1996;32A(6):979-84.
1996: Marcel J Flens; G J Zaman; Paul Van Der Valk; Miguel A Izquierdo; Anouk B Schroeijers; George L Scheffer; P van der Groep; Marcel de Haas; Chris J L M Meijer; Rik J Scheper
Tissue distribution of the multidrug resistance protein.
The American journal of pathology 1996;148(4):1237-47.
1996: Miguel A Izquierdo; George L Scheffer; Marcel J Flens; Giuseppe Giaccone; Henk J Broxterman; Chris J L M Meijer; Paul Van Der Valk; Rik J Scheper
Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors.
The American journal of pathology 1996;148(3):877-87.
1996: Coen C Paulusma; Piter J Bosma; G J Zaman; C T Bakker; M Otter; George L Scheffer; Rik J Scheper; Piet Borst; Ronald P J Oude Elferink
Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene.
Science (New York, N.Y.) 1996;271(5252):1126-8.
1996: Miguel A Izquierdo; Robert H Shoemaker; Marcel J Flens; George L Scheffer; L Wu; T R Prather; Rik J Scheper
Overlapping phenotypes of multidrug resistance among panels of human cancer-cell lines.
International journal of cancer. Journal international du cancer 1996;65(2):230-7.
1996: Miguel A Izquierdo; George L Scheffer; Marcel J Flens; Robert H Shoemaker; Leonard H Rome; Rik J Scheper
Relationship of LRP-human major vault protein to in vitro and clinical resistance to anticancer drugs.
Cytotechnology 1996;19(3):191-7.
1996: Rik J Scheper; George L Scheffer; Marcel J Flens; Paul Van Der Valk; Henk J Broxterman; Miguel A Izquierdo
Transporter molecules in multidrug resistance.
Cytotechnology 1996;19(3):187-90.
1995: Dirk Schadendorf; A Makki; C Stahr; A van Dyck; Reinhard Wanner; George L Scheffer; Marcel J Flens; R Scheper; Beate M Henz
Membrane transport proteins associated with drug resistance expressed in human melanoma.
The American journal of pathology 1995;147(6):1545-52.
1995: Miguel A Izquierdo; Ate G J van der Zee; J B Vermorken; Paul Van Der Valk; Jeroen A M Beliën; Giuseppe Giaccone; George L Scheffer; Marcel J Flens; HERBERT PINEDO; P Kenemans
Drug resistance-associated marker Lrp for prediction of response to chemotherapy and prognoses in advanced ovarian carcinoma.
Journal of the National Cancer Institute 1995;87(16):1230-7.
1995: George L Scheffer; P L Wijngaard; Marcel J Flens; Miguel A Izquierdo; Marilyn L Slovak; HERBERT PINEDO; Chris J L M Meijer; Hans Clevers; Rik J Scheper
The drug resistance-related protein LRP is the human major vault protein.
Nature medicine 1995;1(6):578-82.
1994: Marcel J Flens; Miguel A Izquierdo; George L Scheffer; J M Fritz; Chris J L M Meijer; Rik J Scheper; G J Zaman
Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies.
Cancer research 1994;54(17):4557-63.
1993: Rik J Scheper; Henk J Broxterman; George L Scheffer; P Kaaijk; W S Dalton; T H van Heijningen; C K van Kalken; Marilyn L Slovak; E G de Vries; Paul Van Der Valk
Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.
Cancer research 1993;53(7):1475-9.
1991: Gerrit J Schuurhuis; Henk J Broxterman; J H de Lange; HERBERT PINEDO; T H van Heijningen; CM Kuiper; George L Scheffer; Rik J Scheper; C K van Kalken; Jan P A Baak
Early multidrug resistance, defined by changes in intracellular doxorubicin distribution, independent of P-glycoprotein.
British journal of cancer 1991;64(5):857-61.
1991: C K van Kalken; Paul Van Der Valk; M M Hadisaputro; R Pieters; Henk J Broxterman; CM Kuiper; George L Scheffer; A J Veerman; C J Meyer; Rik J Scheper
Differentiation dependent expression of P-glycoprotein in the normal and neoplastic human kidney.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1991;2(1):55-62.
1990: F Baas; A P Jongsma; Henk J Broxterman; Robert J Arceci; D Housman; George L Scheffer; A Riethorst; Marjon van Groenigen; A W Nieuwint; Hans Joenje
Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line.
Cancer research 1990;50(17):5392-8.
1990: Paul Van Der Valk; C K van Kalken; H Ketelaars; Henk J Broxterman; George L Scheffer; CM Kuiper; T Tsuruo; Jan Lankelma; C J Meijer; HERBERT PINEDO
Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues. Analysis with 3 monoclonal antibodies recognizing different epitopes of the P-glycoprotein molecule.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1990;1(1):56-64.