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George Scheffer
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70
Scheper, Rik
16
Izquierdo, Miguel
16
Flens, Marcel
15
Van Der Valk, Paul
14
Jansen, Gerrit
12
Borst, Piet
12
Wiemer, Erik
11
Broxterman, Henk
11
de Jong, Mariska
9
Schroeijers, Anouk
8
Schoester, Martijn
8
de Haas, Marcel
7
de Gruijl, Tanja
7
Assaraf, Yehuda
7
Hooijberg, Jan Hendrik
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All Publications
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2009: van de Ven Rieneke; Lindenberg Jelle J; Oosterhoff Dinja; van den Tol M Petrousjka; Rosalia Rodney A; Murakami Miho; Everts Maaike; Scheffer George L; Scheper Rik J; de Gruijl Tanja D; Curiel David T
Selective transduction of mature DC in human skin and lymph nodes by CD80/CD86-targeted fiber-modified adenovirus-5/3.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2009;32(9):895-906.
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2009: van de Ven Rieneke; Oerlemans Ruud; van der Heijden Joost W; Scheffer George L; de Gruijl Tanja D; Jansen Gerrit; Scheper Rik J
ABC drug transporters and immunity: novel therapeutic targets in autoimmunity and cancer.
Journal of leukocyte biology 2009;86(5):1075-87.
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2009: van de Ven Rieneke; Scheffer George L; Scheper Rik J; de Gruijl Tanja D
The ABC of dendritic cell development and function.
Trends in immunology 2009;30(9):421-9.
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2009: van de Ven Rieneke; de Groot Jan; Reurs Anneke W; Wijnands Pepijn G J T B; van de Wetering Koen; Schuetz John D; de Gruijl Tanja D; Scheper Rik J; Scheffer George L
Unimpaired immune functions in the absence of Mrp4 (Abcc4).
Immunology letters 2009;124(2):81-7.
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2009: van der Heijden Joost W; Oerlemans Ruud; Tak Paul P; Assaraf Yehuda G; Kraan Maarten C; Scheffer George L; van der Laken Conny J; Lems Willem F; Scheper Rik J; Dijkmans Ben A C; Jansen Gerrit
Involvement of breast cancer resistance protein expression on rheumatoid arthritis synovial tissue macrophages in resistance to methotrexate and leflunomide.
Arthritis and rheumatism 2009;60(3):669-77.
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2009: Lemos Clara; Kathmann Ietje; Giovannetti Elisa; Beliën Jeroen A M; Scheffer George L; Calhau Conceição; Jansen Gerrit; Peters Godefridus J
Cellular folate status modulates the expression of BCRP and MRP multidrug transporters in cancer cell lines from different origins.
Molecular cancer therapeutics 2009;8(3):655-64.
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2008: Lemos Clara; Kathmann Ietje; Giovannetti Elisa; Dekker Henk; Scheffer George L; Calhau Conceição; Jansen Gerrit; Peters Godefridus J
Folate deprivation induces BCRP (ABCG2) expression and mitoxantrone resistance in Caco-2 cells.
International journal of cancer. Journal international du cancer 2008;123(7):1712-20.
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2008: van de Ven Rieneke; Scheffer George L; Reurs Anneke W; Lindenberg Jelle J; Oerlemans Ruud; Jansen Gerrit; Gillet Jean-Pierre; Glasgow Joel N; Pereboev Alexander; Curiel David T; Scheper Rik J; de Gruijl Tanja D
A role for multidrug resistance protein 4 (MRP4; ABCC4) in human dendritic cell migration.
Blood 2008;112(6):2353-9.
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2007: Ono Nobuhito; Van der Heijden Ingrid; Scheffer George L; Van de Wetering Koen; Van Deemter Elizabeth; De Haas Marcel; Boerke Arjan; Gadella Bart M; De Rooij Dirk G; Neefjes Jacques J; Groothuis Tom A M; Oomen Lauran; Brocks Lenny; Ishikawa Toshihisa; Borst Piet
Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm.
The Biochemical journal 2007;406(1):31-40.
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2007: Takenaka Kazumasa; Morgan Jessica A; Scheffer George L; Adachi Masashi; Stewart Clinton F; Sun Daxi; Leggas Markos; Ejendal Karin F K; Hrycyna Christine A; Schuetz John D
Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution.
Cancer research 2007;67(14):6965-72.
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2007: de Wolf Cornelia J F; Yamaguchi Hiroaki; van der Heijden Ingrid; Wielinga Peter R; Hundscheid Stefanie L; Ono Nobuhito; Scheffer George L; de Haas Marcel; Schuetz John D; Wijnholds Jan; Borst Piet
cGMP transport by vesicles from human and mouse erythrocytes.
The FEBS journal 2007;274(2):439-50.
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2007: Breedveld Pauline; Pluim Dick; Cipriani Greta; Dahlhaus Femke; van Eijndhoven Maria A J; de Wolf Cornelia J F; Kuil Annemieke; Beijnen Jos H; Scheffer George L; Jansen Gerrit; Borst Piet; Schellens Jan H M
The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models.
Molecular pharmacology 2007;71(1):240-9.
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2006: van de Ven Rieneke; de Jong Mariska C; Reurs Anneke W; Schoonderwoerd Antoinet J N; Jansen Gerrit; Hooijberg Jan H; Scheffer George L; de Gruijl Tanja D; Scheper Rik J
Dendritic cells require multidrug resistance protein 1 (ABCC1) transporter activity for differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5191-8.
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2006: Zelcer Noam; van de Wetering Koen; de Waart Rudi; Scheffer George L; Marschall Hanns-Ulrich; Wielinga Peter R; Kuil Annemieke; Kunne Cindy; Smith Alexander; van der Valk Martin; Wijnholds Jan; Elferink Ronald Oude; Borst Piet
Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides.
Journal of hepatology 2006;44(4):768-75.
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2006: Oerlemans Ruud; van der Heijden Joost; Vink Josefien; Dijkmans Ben A C; Kaspers Gertjan J L; Lems Willem F; Scheffer George L; Ifergan Ilan; Scheper Rik J; Cloos Jacqueline; Assaraf Yehuda G; Jansen Gerrit
Acquired resistance to chloroquine in human CEM T cells is mediated by multidrug resistance-associated protein 1 and provokes high levels of cross-resistance to glucocorticoids.
Arthritis and rheumatism 2006;54(2):557-68.
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2006: van Zon Arend; Mossink Marieke H; Houtsmuller Adriaan B; Schoester Martijn; Scheffer George L; Scheper Rik J; Sonneveld Pieter; Wiemer Erik A C
Vault mobility depends in part on microtubules and vaults can be recruited to the nuclear envelope.
Experimental cell research 2006;312(3):245-55.
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2005: Ifergan Ilan; Scheffer George L; Assaraf Yehuda G
Novel extracellular vesicles mediate an ABCG2-dependent anticancer drug sequestration and resistance.
Cancer research 2005;65(23):10952-8.
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2005: Gorgels Theo G M F; Hu Xiaofeng; Scheffer George L; van der Wal Allard C; Toonstra Johan; de Jong Paulus T V M; van Kuppevelt Toin H; Levelt Christiaan N; de Wolf Anneke; Loves Willem J P; Scheper Rik J; Peek Ron; Bergen Arthur A B
Disruption of Abcc6 in the mouse: novel insight in the pathogenesis of pseudoxanthoma elasticum.
Human molecular genetics 2005;14(13):1763-73.
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2005: Norris Murray D; Smith Janice; Tanabe Kara; Tobin Peter; Flemming Claudia; Scheffer George L; Wielinga Peter; Cohn Susan L; London Wendy B; Marshall Glenn M; Allen John D; Haber Michelle
Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro.
Molecular cancer therapeutics 2005;4(4):547-53.
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2005: Greijer A E; de Jong M C; Scheffer G L; Shvarts A; van Diest P J; van der Wall E
Hypoxia-induced acidification causes mitoxantrone resistance not mediated by drug transporters in human breast cancer cells.
Cellular oncology : the official journal of the International Society for Cellular Oncology 2005;27(1):43-9.
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2004: Leggas Markos; Adachi Masashi; Scheffer George L; Sun Daxi; Wielinga Peter; Du Guoqing; Mercer Kelly E; Zhuang Yanli; Panetta John C; Johnston Brad; Scheper Rik J; Stewart Clinton F; Schuetz John D
Mrp4 confers resistance to topotecan and protects the brain from chemotherapy.
Molecular and cellular biology 2004;24(17):7612-21.
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2004: Ifergan Ilan; Shafran Assaf; Jansen Gerrit; Hooijberg Jan Hendrik; Scheffer George L; Assaraf Yehuda G
Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression. A role for BCRP in cellular folate homeostasis.
The Journal of biological chemistry 2004;279(24):25527-34.
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2004: van der Heijden J; de Jong M C; Dijkmans B A C; Lems W F; Oerlemans R; Kathmann I; Schalkwijk C G; Scheffer G L; Scheper R J; Jansen G
Development of sulfasalazine resistance in human T cells induces expression of the multidrug resistance transporter ABCG2 (BCRP) and augmented production of TNFalpha.
Annals of the rheumatic diseases 2004;63(2):138-43.
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2004: van der Heijden J; de Jong M C; Dijkmans B A C; Lems W F; Oerlemans R; Kathmann I; Scheffer G L; Scheper R J; Assaraf Y G; Jansen G
Acquired resistance of human T cells to sulfasalazine: stability of the resistant phenotype and sensitivity to non-related DMARDs.
Annals of the rheumatic diseases 2004;63(2):131-7.
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2003: Plasschaert Sabine L A; van der Kolk Dorina M; de Bont Eveline S J M; Kamps Willem A; Morisaki Kuniaki; Bates Susan E; Scheffer George L; Scheper Rik J; Vellenga Edo; de Vries Elisabeth G E
The role of breast cancer resistance protein in acute lymphoblastic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(14):5171-7.
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2003: van Zon Arend; Mossink Marieke H; Schoester Martijn; Houtsmuller Adriaan B; Scheffer George L; Scheper Rik J; Sonneveld Pieter; Wiemer Erik A C
The formation of vault-tubes: a dynamic interaction between vaults and vault PARP.
Journal of cell science 2003;116(Pt 21):4391-400.
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2003: de Jong Mariska C; Scheffer George L; Broxterman Henk J; Hooijberg Jan H; Slootstra Jerry W; Meloen Rob H; Kreitman Robert J; Husain Syed R; Joshi Bharat H; Puri Raj K; Scheper Rik J
Multidrug-resistant tumor cells remain sensitive to a recombinant interleukin-4-Pseudomonas exotoxin, except when overexpressing the multidrug resistance protein MRP1.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(13):5009-17.
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2003: Diestra Julio E; Condom Enric; Del Muro Xavier García; Scheffer George L; Pérez Javier; Zurita Amado J; Muñoz-Seguí José; Vigués Francisco; Scheper Rik J; Capellá Gabriel; Germà-Lluch José R; Izquierdo Miguel A
Expression of multidrug resistance proteins P-glycoprotein, multidrug resistance protein 1, breast cancer resistance protein and lung resistance related protein in locally advanced bladder cancer treated with neoadjuvant chemotherapy: biological and clinical implications.
The Journal of urology 2003;170(4 Pt 1):1383-7.
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2003: Mossink Marieke H; de Groot Jan; van Zon Arend; Fränzel-Luiten Erna; Schoester Martijn; Scheffer George L; Sonneveld Pieter; Scheper Rik J; Wiemer Erik A C
Unimpaired dendritic cell functions in MVP/LRP knockout mice.
Immunology 2003;110(1):58-65.
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2003: Stark Michal; Rothem Lilah; Jansen Gerrit; Scheffer George L; Goldman I David; Assaraf Yehuda G
Antifolate resistance associated with loss of MRP1 expression and function in Chinese hamster ovary cells with markedly impaired export of folate and cholate.
Molecular pharmacology 2003;64(2):220-7.
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2003: Zurita A J; Diestra J E; Condom E; García Del Muro X; Scheffer G L; Scheper R J; Pérez J; Germà-Lluch J R; Izquierdo M A
Lung resistance-related protein as a predictor of clinical outcome in advanced testicular germ-cell tumours.
British journal of cancer 2003;88(6):879-86.
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2003: Hooijberg Jan Hendrik; Peters Godefridus J; Assaraf Yehuda G; Kathmann Ietje; Priest David G; Bunni Marlene A; Veerman Anjo J P; Scheffer George L; Kaspers Gertjan J L; Jansen Gerrit
The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis.
Biochemical pharmacology 2003;65(5):765-71.
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2003: van der Pol Marjolein A; Broxterman Henk J; Pater Jennie M; Feller Nicole; van der Maas Martin; Weijers Geert W D; Scheffer George L; Allen John D; Scheper Rik J; van Loevezijn Arnold; Ossenkoppele Gert J; Schuurhuis Gerrit J
Function of the ABC transporters, P-glycoprotein, multidrug resistance protein and breast cancer resistance protein, in minimal residual disease in acute myeloid leukemia.
Haematologica 2003;88(2):134-47.
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2003: Mayer Frank; Stoop Hans; Scheffer George L; Scheper Rik; Oosterhuis J Wolter; Looijenga Leendert H J; Bokemeyer Carsten
Molecular determinants of treatment response in human germ cell tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(2):767-73.
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2002: Mossink Marieke H; van Zon Arend; Fränzel-Luiten Erna; Schoester Martijn; Kickhoefer Valerie A; Scheffer George L; Scheper Rik J; Sonneveld Pieter; Wiemer Erik A C
Disruption of the murine major vault protein (MVP/LRP) gene does not induce hypersensitivity to cytostatics.
Cancer research 2002;62(24):7298-304.
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2002: Jonker Johan W; Buitelaar Marije; Wagenaar Els; Van Der Valk Martin A; Scheffer George L; Scheper Rik J; Plosch Torsten; Kuipers Folkert; Elferink Ronald P J Oude; Rosing Hilde; Beijnen Jos H; Schinkel Alfred H
The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15649-54.
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2002: Diestra Julio E; Scheffer George L; Català Isabel; Maliepaard Marc; Schellens Jan H M; Scheper Rik J; Germà-Lluch Jose R; Izquierdo Miguel A
Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material.
The Journal of pathology 2002;198(2):213-9.
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2002: van Hattum A H; Hoogsteen I J; Schlüper H M M; Maliepaard M; Scheffer G L; Scheper R J; Kohlhagen G; Pommier Y; Pinedo H M; Boven E
Induction of breast cancer resistance protein by the camptothecin derivative DX-8951f is associated with minor reduction of antitumour activity.
British journal of cancer 2002;87(6):665-72.
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2002: Mossink Marieke; van Zon Arend; Fränzel-Luiten Erna; Schoester Martijn; Scheffer George L; Scheper Rik J; Sonneveld Pieter; Wiemer Erik A C
The genomic sequence of the murine major vault protein and its promoter.
Gene 2002;294(1-2):225-32.
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2002: Scheffer George L; Flens Marcel J; Hageman Sandra; Izquierdo Miguel A; Shoemaker Robert H; Scheper Rik J
Expression of the vascular endothelial cell protein C receptor in epithelial tumour cells.
European journal of cancer (Oxford, England : 1990) 2002;38(11):1535-42.
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2002: Scheffer G L; de Jong M C; Monks A; Flens M J; Hose C D; Izquierdo M A; Shoemaker R H; Scheper R J
Increased expression of beta 2-microglobulin in multidrug-resistant tumour cells.
British journal of cancer 2002;86(12):1943-50.
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2002: Scheffer G L; Pijnenborg A C L M; Smit E F; Müller M; Postma D S; Timens W; van der Valk P; de Vries E G E; Scheper R J
Multidrug resistance related molecules in human and murine lung.
Journal of clinical pathology 2002;55(5):332-9.
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2002: van der Kolk Dorina M; Vellenga Edo; Scheffer George L; Müller Michael; Bates Susan E; Scheper Rik J; de Vries Elisabeth G E
Expression and activity of breast cancer resistance protein (BCRP) in de novo and relapsed acute myeloid leukemia.
Blood 2002;99(10):3763-70.
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2002: Scheffer George L; Hu Xiaofeng; Pijnenborg Adriana C L M; Wijnholds Jan; Bergen Arthur A B; Scheper Rik J
MRP6 (ABCC6) detection in normal human tissues and tumors.
Laboratory investigation; a journal of technical methods and pathology 2002;82(4):515-8.
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2002: Faneyte Ian F; Kristel Petra M P; Maliepaard Marc; Scheffer George L; Scheper Rik J; Schellens Jan H M; van de Vijver Marc J
Expression of the breast cancer resistance protein in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(4):1068-74.
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2002: Scheffer G L; Reurs A W; Jutten B; Beiboer S H W; van Amerongen R; Schoester M; Wiemer E A C; Hoogenboom H R; Scheper R J
Selection and characterisation of a phage-displayed human antibody (Fab) reactive to the lung resistance-related major vault protein.
British journal of cancer 2002;86(6):954-62.
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2002: van Zon Arend; Mossink Marieke H; Schoester Martijn; Scheffer George L; Scheper Rik J; Sonneveld Pieter; Wiemer Erik A C
Structural domains of vault proteins: a role for the coiled coil domain in vault assembly.
Biochemical and biophysical research communications 2002;291(3):535-41.
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2002: Scheffer George L; Kool Marcel; de Haas Marcel; de Vree J Marleen L; Pijnenborg Adriana C L M; Bosman Diederik K; Elferink Ronald P J Oude; van der Valk Paul; Borst Piet; Scheper Rik J
Tissue distribution and induction of human multidrug resistant protein 3.
Laboratory investigation; a journal of technical methods and pathology 2002;82(2):193-201.
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2002: Schroeijers Anouk B; Reurs Anneke W; Scheffer George L; Stam Anita G M; de Jong Mariska C; Rustemeyer Thomas; Wiemer Erik A C; de Gruijl Tanja D; Scheper Rik J
Up-regulation of drug resistance-related vaults during dendritic cell development.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1572-8.
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2002: Brinkhuis Mariël; Izquierdo Miguel A; Baak Jan P A; van Diest Paul J; Kenemans Peter; Scheffer George L; Scheper Rik J
Expression of multidrug resistance-associated markers, their relation to quantitative pathologic tumour characteristics and prognosis in advanced ovarian cancer.
Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology 2002;24(1):17-23.
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2002: Scheffer George L; Scheper Rik J
Drug resistance molecules: lessons from oncology.
Novartis Foundation symposium 2002;243():19-31; discussion 31-7, 180-5.
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2001: Schroeijers A B; Scheffer G L; Reurs A W; Pijnenborg A C; Abbondanza C; Wiemer E A; Scheper R J
Detection of the Mr 110,000 lung resistance-related protein LRP/MVP with monoclonal antibodies.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2001;49(11):1379-85.
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2001: van Zon A; Mossink M H; Schoester M; Scheffer G L; Scheper R J; Sonneveld P; Wiemer E A
Multiple human vault RNAs. Expression and association with the vault complex.
The Journal of biological chemistry 2001;276(40):37715-21.
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2001: Maliepaard M; Scheffer G L; Faneyte I F; van Gastelen M A; Pijnenborg A C; Schinkel A H; van De Vijver M J; Scheper R J; Schellens J H
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.
Cancer research 2001;61(8):3458-64.
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2001: de Jong M C; Slootstra J W; Scheffer G L; Schroeijers A B; Puijk W C; Dinkelberg R; Kool M; Broxterman H J; Meloen R H; Scheper R J
Peptide transport by the multidrug resistance protein MRP1.
Cancer research 2001;61(6):2552-7.
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2001: Bladergroen B A; Strik M C; Bovenschen N; van Berkum O; Scheffer G L; Meijer C J; Hack C E; Kummer J A
The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3218-25.
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2001: Erlichman C; Boerner S A; Hallgren C G; Spieker R; Wang X Y; James C D; Scheffer G L; Maliepaard M; Ross D D; Bible K C; Kaufmann S H
The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux.
Cancer research 2001;61(2):739-48.
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2000: Scheffer G L; Schroeijers A B; Izquierdo M A; Wiemer E A; Scheper R J
Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer.
Current opinion in oncology 2000;12(6):550-6.
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2000: Scheffer G L; Kool M; Heijn M; de Haas M; Pijnenborg A C; Wijnholds J; van Helvoort A; de Jong M C; Hooijberg J H; Mol C A; van der Linden M; de Vree J M; van der Valk P; Elferink R P; Borst P; Scheper R J
Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies.
Cancer research 2000;60(18):5269-77.
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2000: Wijnholds J; Mol C A; van Deemter L; de Haas M; Scheffer G L; Baas F; Beijnen J H; Scheper R J; Hatse S; De Clercq E; Balzarini J; Borst P
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7476-81.
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2000: Scheffer G L; Maliepaard M; Pijnenborg A C; van Gastelen M A; de Jong M C; Schroeijers A B; van der Kolk D M; Allen J D; Ross D D; van der Valk P; Dalton W S; Schellens J H; Scheper R J
Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines.
Cancer research 2000;60(10):2589-93.
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2000: Schroeijers A B; Siva A C; Scheffer G L; de Jong M C; Bolick S C; Dukers D F; Slootstra J W; Meloen R H; Wiemer E; Kickhoefer V A; Rome L H; Scheper R J
The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines.
Cancer research 2000;60(4):1104-10.
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2000: Wijnholds J; deLange E C; Scheffer G L; van den Berg D J; Mol C A; van der Valk M; Schinkel A H; Scheper R J; Breimer D D; Borst P
Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier.
The Journal of clinical investigation 2000;105(3):279-85.
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2000: Schellens J H; Maliepaard M; Scheper R J; Scheffer G L; Jonker J W; Smit J W; Beijnen J H; Schinkel A H
Transport of topoisomerase I inhibitors by the breast cancer resistance protein. Potential clinical implications.
Annals of the New York Academy of Sciences 2000;922():188-94.
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1999: Arts H J; Katsaros D; de Vries E G; Massobrio M; Genta F; Danese S; Arisio R; Scheper R J; Kool M; Scheffer G L; Willemse P H; van der Zee A G; Suurmeijer A J
Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(10):2798-805.
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1999: Hooijberg J H; Broxterman H J; Scheffer G L; Vrasdonk C; Heijn M; de Jong M C; Scheper R J; Lankelma J; Pinedo H M
Potent interaction of flavopiridol with MRP1.
British journal of cancer 1999;81(2):269-76.
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1999: Kool M; van der Linden M; de Haas M; Scheffer G L; de Vree J M; Smith A J; Jansen G; Peters G J; Ponne N; Scheper R J; Elferink R P; Baas F; Borst P
MRP3, an organic anion transporter able to transport anti-cancer drugs.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6914-9.
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1999: van Haselen C W; Flens M J; Scheper R J; van der Valk P; Scheffer G L; Toonstra J; van Vloten W A
Multidrug resistance related proteins in primary cutaneous lymphomas.
Advances in experimental medicine and biology 1999;457():119-31.
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1998: Kickhoefer V A; Rajavel K S; Scheffer G L; Dalton W S; Scheper R J; Rome L H
Vaults are up-regulated in multidrug-resistant cancer cell lines.
The Journal of biological chemistry 1998;273(15):8971-4.
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1998: Schroeijers A B; Scheffer G L; Flens M J; Meijer G A; Izquierdo M A; van der Valk P; Scheper R J
Immunohistochemical detection of the human major vault protein LRP with two monoclonal antibodies in formalin-fixed, paraffin-embedded tissues.
The American journal of pathology 1998;152(2):373-8.
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1997: Flens M J; Scheffer G L; van der Valk P; Broxterman H J; Eijdems E W; Huysmans A C; Izquierdo M A; Scheper R J
Identification of novel drug resistance-associated proteins by a panel of rat monoclonal antibodies.
International journal of cancer. Journal international du cancer 1997;73(2):249-57.
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1997: Kool M; de Haas M; Scheffer G L; Scheper R J; van Eijk M J; Juijn J A; Baas F; Borst P
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.
Cancer research 1997;57(16):3537-47.
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1997: Paulusma C C; Kool M; Bosma P J; Scheffer G L; ter Borg F; Scheper R J; Tytgat G N; Borst P; Baas F; Oude Elferink R P
A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome.
Hepatology (Baltimore, Md.) 1997;25(6):1539-42.
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1997: Heijn M; Hooijberg J H; Scheffer G L; Szabó G; Westerhoff H V; Lankelma J
Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport.
Biochimica et biophysica acta 1997;1326(1):12-22.
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1996: Izquierdo M A; Neefjes J J; Mathari A E; Flens M J; Scheffer G L; Scheper R J
Overexpression of the ABC transporter TAP in multidrug-resistant human cancer cell lines.
British journal of cancer 1996;74(12):1961-7.
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1996: Izquierdo M A; Scheffer G L; Flens M J; Schroeijers A B; van der Valk P; Scheper R J
Major vault protein LRP-related multidrug resistance.
European journal of cancer (Oxford, England : 1990) 1996;32A(6):979-84.
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1996: Flens M J; Zaman G J; van der Valk P; Izquierdo M A; Schroeijers A B; Scheffer G L; van der Groep P; de Haas M; Meijer C J; Scheper R J
Tissue distribution of the multidrug resistance protein.
The American journal of pathology 1996;148(4):1237-47.
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1996: Izquierdo M A; Scheffer G L; Flens M J; Giaccone G; Broxterman H J; Meijer C J; van der Valk P; Scheper R J
Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors.
The American journal of pathology 1996;148(3):877-87.
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1996: Paulusma C C; Bosma P J; Zaman G J; Bakker C T; Otter M; Scheffer G L; Scheper R J; Borst P; Oude Elferink R P
Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene.
Science (New York, N.Y.) 1996;271(5252):1126-8.
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1996: Izquierdo M A; Shoemaker R H; Flens M J; Scheffer G L; Wu L; Prather T R; Scheper R J
Overlapping phenotypes of multidrug resistance among panels of human cancer-cell lines.
International journal of cancer. Journal international du cancer 1996;65(2):230-7.
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1996: Izquierdo M A; Scheffer G L; Flens M J; Shoemaker R H; Rome L H; Scheper R J
Relationship of LRP-human major vault protein to in vitro and clinical resistance to anticancer drugs.
Cytotechnology 1996;19(3):191-7.
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1996: Scheper R J; Scheffer G L; Flens M J; van der Valk P; Broxterman H J; Izquierdo M A
Transporter molecules in multidrug resistance.
Cytotechnology 1996;19(3):187-90.
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1995: Schadendorf D; Makki A; Stahr C; van Dyck A; Wanner R; Scheffer G L; Flens M J; Scheper R; Henz B M
Membrane transport proteins associated with drug resistance expressed in human melanoma.
The American journal of pathology 1995;147(6):1545-52.
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1995: Izquierdo M A; van der Zee A G; Vermorken J B; van der Valk P; Beliën J A; Giaccone G; Scheffer G L; Flens M J; Pinedo H M; Kenemans P
Drug resistance-associated marker Lrp for prediction of response to chemotherapy and prognoses in advanced ovarian carcinoma.
Journal of the National Cancer Institute 1995;87(16):1230-7.
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1995: Scheffer G L; Wijngaard P L; Flens M J; Izquierdo M A; Slovak M L; Pinedo H M; Meijer C J; Clevers H C; Scheper R J
The drug resistance-related protein LRP is the human major vault protein.
Nature medicine 1995;1(6):578-82.
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1994: Flens M J; Izquierdo M A; Scheffer G L; Fritz J M; Meijer C J; Scheper R J; Zaman G J
Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies.
Cancer research 1994;54(17):4557-63.
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1993: Scheper R J; Broxterman H J; Scheffer G L; Kaaijk P; Dalton W S; van Heijningen T H; van Kalken C K; Slovak M L; de Vries E G; van der Valk P
Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.
Cancer research 1993;53(7):1475-9.
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1991: Schuurhuis G J; Broxterman H J; de Lange J H; Pinedo H M; van Heijningen T H; Kuiper C M; Scheffer G L; Scheper R J; van Kalken C K; Baak J P
Early multidrug resistance, defined by changes in intracellular doxorubicin distribution, independent of P-glycoprotein.
British journal of cancer 1991;64(5):857-61.
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1991: van Kalken C K; van der Valk P; Hadisaputro M M; Pieters R; Broxterman H J; Kuiper C M; Scheffer G L; Veerman A J; Meyer C J; Scheper R J
Differentiation dependent expression of P-glycoprotein in the normal and neoplastic human kidney.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1991;2(1):55-62.
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1990: Baas F; Jongsma A P; Broxterman H J; Arceci R J; Housman D; Scheffer G L; Riethorst A; van Groenigen M; Nieuwint A W; Joenje H
Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line.
Cancer research 1990;50(17):5392-8.
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1990: van der Valk P; van Kalken C K; Ketelaars H; Broxterman H J; Scheffer G; Kuiper C M; Tsuruo T; Lankelma J; Meijer C J; Pinedo H M
Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues. Analysis with 3 monoclonal antibodies recognizing different epitopes of the P-glycoprotein molecule.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1990;1(1):56-64.
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