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Martin Scheffner

Research Profile

Chemicals & Drugs

Anatomy

Disorders

Uterine Cervical Neoplasms

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Gaurav V Harlalka; Simone Kühnle; Deborah J G Mackay; Konstantin Matentzoglu; Michael A Patton; Jose Luis Rosa; Martin Scheffner; Karin Wagner; Emma L Baple; Barry Chioza; Roselyn Coblentz; Harold Cross; Monica Cubillos-Rojas; Debra L Ford; Andrew H Crosby
Mutation of HERC2 causes developmental delay with Angelman-like features.
Silvia Eger; Andreas Marx; Martin Scheffner; Marina Rubini
Formation of ubiquitin dimers via azide-alkyne click reaction.
Ji Eun Jung; Andreas Marquardt; Nicholas A Pierson; Michael Przybylski; Martin Scheffner; David E Clemmer
Differentiation of compact and extended conformations of di-ubiquitin conjugates with lysine-specific isopeptide linkages by ion mobility-mass spectrometry.

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All Publications

2013: Gaurav V Harlalka; Simone Kühnle; Deborah J G Mackay; Konstantin Matentzoglu; Michael A Patton; Jose Luis Rosa; Martin Scheffner; Karin Wagner; Emma L Baple; Barry Chioza; Roselyn Coblentz; Harold Cross; Monica Cubillos-Rojas; Debra L Ford; Andrew H Crosby
Mutation of HERC2 causes developmental delay with Angelman-like features.
Journal of medical genetics 2013;50(2):65-73.
2012: Silvia Eger; Andreas Marx; Martin Scheffner; Marina Rubini
Formation of ubiquitin dimers via azide-alkyne click reaction.
Methods in molecular biology (Clifton, N.J.) 2012;832():589-96.
2011: Ji Eun Jung; Andreas Marquardt; Nicholas A Pierson; Michael Przybylski; Martin Scheffner; David E Clemmer
Differentiation of compact and extended conformations of di-ubiquitin conjugates with lysine-specific isopeptide linkages by ion mobility-mass spectrometry.
Journal of the American Society for Mass Spectrometry 2011;22(8):1463-71.
2010: Silvia Eger; Martin Scheffner; Andreas Marx; Marina Rubini
Synthesis of defined ubiquitin dimers.
Journal of the American Chemical Society 2010;132(46):16337-9.
2009: Claire Cullmann; Karin Hoppe-Seyler; Susanne Dymalla; Claudia Lohrey; Martin Scheffner; Matthias Dürst; Felix Hoppe-Seyler
Oncogenic human papillomaviruses block expression of the B-cell translocation gene-2 tumor suppressor gene.
International journal of cancer. Journal international du cancer 2009;125(9):2014-20.
2009: Ji Eun Jung; Hans-Peter Wollscheid; Andreas Marquardt; Marilena Manea; Martin Scheffner; Michael Przybylski
Functional ubiquitin conjugates with lysine-epsilon-amino-specific linkage by thioether ligation of cysteinyl-ubiquitin peptide building blocks.
Bioconjugate chemistry 2009;20(6):1152-62.
2009: Susanne Dymalla; Martin Scheffner; Elvira Weber; Peter Sehr; Claudia Lohrey; Felix Hoppe-Seyler; Karin Hoppe-Seyler
A novel peptide motif binding to and blocking the intracellular activity of the human papillomavirus E6 oncoprotein.
Journal of molecular medicine (Berlin, Germany) 2009;87(3):321-31.
2009: Konstantin Matentzoglu; Martin Scheffner
Ubiquitin-fusion protein system: a powerful tool for ectopic protein expression in mammalian cells.
BioTechniques 2009;46(1):21-2, 24, 26 passim.
2008: Konstantin Matentzoglu; Martin Scheffner
Ubiquitin ligase E6-AP and its role in human disease.
Biochemical Society transactions 2008;36(Pt 5):797-801.
2007: Stephanie Töpffer; Andreas Müller-Schiffmann; Konstantin Matentzoglu; Martin Scheffner; Gertrud Steger
Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses.
The Journal of general virology 2007;88(Pt 11):2956-65.
2007: Christiane Pelzer; Ingrid Kassner; Konstantin Matentzoglu; Rajesh K Singh; Hans-Peter Wollscheid; Martin Scheffner; Gunter Schmidtke; Marcus Groettrup
UBE1L2, a novel E1 enzyme specific for ubiquitin.
The Journal of biological chemistry 2007;282(32):23010-4.
2007: Rajesh K Singh; Saravanakumar Iyappan; Martin Scheffner
Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2.
The Journal of biological chemistry 2007;282(15):10901-7.
2007: Petric Kuballa; Konstantin Matentzoglu; Martin Scheffner
The role of the ubiquitin ligase E6-AP in human papillomavirus E6-mediated degradation of PDZ domain-containing proteins.
The Journal of biological chemistry 2007;282(1):65-71.
2007: Martin Scheffner; Olivier Staub
HECT E3s and human disease.
BMC biochemistry 2007;8 Suppl 1():S6.
2006: Abdelmajid Sabile; Andrea Michael Meyer; Christiane Wirbelauer; daniel Hess; Ulrike Kogel; Martin Scheffner; Wilhelm Krek
Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein.
Molecular and cellular biology 2006;26(16):5994-6004.
2005: Daniëlle A M Heideman; Renske D M Steenbergen; Jaco van der Torre; Martin Scheffner; Ramon Alemany; Winald Gerritsen; Chris J L M Meijer; Peter J F Snijders; Victor W van Beusechem
Oncolytic adenovirus expressing a p53 variant resistant to degradation by HPV E6 protein exhibits potent and selective replication in cervical cancer.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(6):1083-90.
2005: Sovana Adhikary; Federica Marinoni; Andreas Hock; Esther Hulleman; Nikita Popov; Rudi Beier; Sandra Bernard; Micaela Quarto; Maria Capra; Stephan Goettig; Ulrike Kogel; Martin Scheffner; Kristian Helin; Martin Eilers
The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation.
Cell 2005;123(3):409-21.
2005: Claudia Esser; Martin Scheffner; Jörg Höhfeld
The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation.
The Journal of biological chemistry 2005;280(29):27443-8.
2005: Arnd Hengstermann; Michael A D'silva; Petric Kuballa; Karin Butz; Felix Hoppe-Seyler; Martin Scheffner
Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53.
Journal of virology 2005;79(14):9296-300.
2004: Wolfgang Baumeister; Andreas Bachmair; Vincent Chau; Robert E Cohen; Philip Coffino; George Demartino; Raymond J Deshaies; Juergen Dohmen; Scott Emr; Daniel Finley; Randy Hampton; Christopher Hill; Mark Hochstrasser; Robert Huber; Peter Jackson; Stefan Jentsch; Erica Johnson; Yong Tae Kwon; Michele Pagano; Cecile M Pickart; Martin Rechsteiner; Martin Scheffner; Thomas Sommer; William Tansey; Mike Tyers; Richard D Vierstra; Allan Weissman; Keith Wilkinson; Dieter Wolf
Varshavsky's contributions.
Science (New York, N.Y.) 2004;306(5700):1290-2.
2004: Gaëlle Legube; Laëtitia K Linares; Sandrine Tyteca; Cécile Caron; Martin Scheffner; Martine Chevillard-Briet; Didier Trouche
Role of the histone acetyl transferase Tip60 in the p53 pathway.
The Journal of biological chemistry 2004;279(43):44825-33.
2003: Sandra Glockzin; Francois-Xavier Ogi; Arnd Hengstermann; Martin Scheffner; Christine Blattner
Involvement of the DNA repair protein hHR23 in p53 degradation.
Molecular and cellular biology 2003;23(24):8960-9.
2003: Laëtitia K Linares; Martin Scheffner
The ubiquitin-protein ligase activity of Hdm2 is inhibited by nucleic acids.
FEBS letters 2003;554(1-2):73-6.
2003: Laëtitia K Linares; Arnd Hengstermann; Aaron Ciechanover; Stefan Müller; Martin Scheffner
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12009-14.
2003: Karin Butz; Tutik Ristriani; Arnd Hengstermann; Claudia Denk; Martin Scheffner; Felix Hoppe-Seyler
siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells.
Oncogene 2003;22(38):5938-45.
2003: Vanessa Brès; Rosemary Kiernan; Laëtitia K Linares; Christine Chable-Bessia; Olga Plechakova; Céline Tréand; Stéphane Emiliani; JEAN-MARIE ALAIN PELOPONESE; Kuan-Teh Jeang; Olivier Coux; Martin Scheffner; Monsef Benkirane
A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter.
Nature cell biology 2003;5(8):754-61.
2003: Martin Scheffner; Noel J Whitaker
Human papillomavirus-induced carcinogenesis and the ubiquitin-proteasome system.
Seminars in cancer biology 2003;13(1):59-67.
2002: Gaëlle Legube; Laëtitia K Linares; Claudie Lemercier; Martin Scheffner; Saadi Khochbin; Didier Trouche
Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation.
The EMBO journal 2002;21(7):1704-12.
2002: Heather P Ostendorff; Reto I Peirano; Marvin A Peters; Anne Schlüter; Michael Bossenz; Martin Scheffner; Ingolf Bach
Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.
Nature 2002;416(6876):99-103.
2002: Yasuyuki Fujita; Gerd Krause; Martin Scheffner; Dietmar Zechner; Hugo E Molina Leddy; Jürgen Behrens; Thomas Sommer; Walter Birchmeier
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex.
Nature cell biology 2002;4(3):222-31.
2001: Martin Scheffner; Noel J Whitaker
Cell biology. Proteolytic relay comes to an end.
Nature 2001;410(6831):882-3, 885.
2001: Arnd Hengstermann; Laëtitia K Linares; Aaron Ciechanover; Noel J Whitaker; Martin Scheffner
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):1218-23.
2000: Karin Butz; Claudia Denk; A Ullmann; Martin Scheffner; Felix Hoppe-Seyler
Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6693-7.
1999: Monica Gostissa; Arnd Hengstermann; V Fogal; Peter Sandy; S E Schwarz; Martin Scheffner; Giannino Del Sal
Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.
The EMBO journal 1999;18(22):6462-71.
1999: TP Moynihan; Helen C Ardley; U Nuber; Stephen A Rose; Pam Jones; Alexander F Markham; Martin Scheffner; Philip A Robinson
The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1.
The Journal of biological chemistry 1999;274(43):30963-8.
1999: TP Moynihan; U Nuber; Helen C Ardley; Stephen A Rose; Alexander F Markham; Martin Scheffner; Philip A Robinson
Characterization of the mouse ubiquitin-conjugating enzyme gene UbcM4.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(10):977-82.
1999: S Glockzin; A von Knethen; Martin Scheffner; Bernhard Brüne
Activation of the cell death program by nitric oxide involves inhibition of the proteasome.
The Journal of biological chemistry 1999;274(28):19581-6.
1999: A Marti; Christiane Wirbelauer; Martin Scheffner; Wilhelm Krek
Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation.
Nature cell biology 1999;1(1):14-9.
1999: U Nuber; Martin Scheffner
Identification of determinants in E2 ubiquitin-conjugating enzymes required for hect E3 ubiquitin-protein ligase interaction.
The Journal of biological chemistry 1999;274(11):7576-82.
1998: Arnd Hengstermann; Noel J Whitaker; D Zimmer; Hanswalter Zentgraf; Martin Scheffner
Characterization of sequence elements involved in p53 stability regulation reveals cell type dependence for p53 degradation.
Oncogene 1998;17(22):2933-41.
1998: T Rothmann; Arnd Hengstermann; Noel J Whitaker; Martin Scheffner; Harald zur Hausen
Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells.
Journal of virology 1998;72(12):9470-8.
1998: U Nuber; SE Schwarz; Martin Scheffner
The ubiquitin-protein ligase E6-associated protein (E6-AP) serves as its own substrate.
European journal of biochemistry / FEBS 1998;254(3):643-9.
1998: Martin Scheffner
Ubiquitin, E6-AP, and their role in p53 inactivation.
Pharmacology & therapeutics 1998;78(3):129-39.
1998: SE Schwarz; J L Rosa; Martin Scheffner
Characterization of human hect domain family members and their interaction with UbcH5 and UbcH7.
The Journal of biological chemistry 1998;273(20):12148-54.
1998: W Meschede; Klaus Zumbach; J Braspenning; Martin Scheffner; L Benitez-Bribiesca; J Luande; Lutz Gissmann; Michael Pawlita
Antibodies against early proteins of human papillomaviruses as diagnostic markers for invasive cervical cancer.
Journal of clinical microbiology 1998;36(2):475-80.
1998: SE Schwarz; Kai Matuschewski; D Liakopoulos; Martin Scheffner; Stefan Jentsch
The ubiquitin-like proteins SMT3 and SUMO-1 are conjugated by the UBC9 E2 enzyme.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):560-4.
1996: U Nuber; S Schwarz; P Kaiser; R Schneider; Martin Scheffner
Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5.
The Journal of biological chemistry 1996;271(5):2795-800.
1995: Jon M Huibregtse; Martin Scheffner; Sylvie Beaudenon; Peter M Howley
A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):5249.
1995: Jon M Huibregtse; Martin Scheffner; Sylvie Beaudenon; Peter M Howley
A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2563-7.
1995: Martin Scheffner; U Nuber; Jon M Huibregtse
Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade.
Nature 1995;373(6509):81-3.
1994: Martin Scheffner; Jon M Huibregtse; Peter M Howley
Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(19):8797-801.
1994: Martin Scheffner; H Romanczuk; K Münger; Jon M Huibregtse; J A Mietz; Peter M Howley
Functions of human papillomavirus proteins.
Current topics in microbiology and immunology 1994;186():83-99.
1994: Jon M Huibregtse; Martin Scheffner; Peter M Howley
E6-AP directs the HPV E6-dependent inactivation of p53 and is representative of a family of structurally and functionally related proteins.
Cold Spring Harbor symposia on quantitative biology 1994;59():237-45.
1993: Martin Scheffner; Jon M Huibregtse; Richard D Vierstra; Peter M Howley
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53.
Cell 1993;75(3):495-505.
1993: T Unger; J A Mietz; Martin Scheffner; C L Yee; Peter M Howley
Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression.
Molecular and cellular biology 1993;13(9):5186-94.
1993: Jon M Huibregtse; Martin Scheffner; Peter M Howley
Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins.
Molecular and cellular biology 1993;13(8):4918-27.
1993: Jon M Huibregtse; Martin Scheffner; Peter M Howley
Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.
Molecular and cellular biology 1993;13(2):775-84.
1992: Martin Scheffner; T Takahashi; Jon M Huibregtse; J D Minna; Peter M Howley
Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins.
Journal of virology 1992;66(8):5100-5.
1992: Martin Scheffner; K Münger; Jon M Huibregtse; Peter M Howley
Targeted degradation of the retinoblastoma protein by human papillomavirus E7-E6 fusion proteins.
The EMBO journal 1992;11(7):2425-31.
1992: K Münger; Martin Scheffner; Jon M Huibregtse; Peter M Howley
Interactions of HPV E6 and E7 oncoproteins with tumour suppressor gene products.
Cancer surveys 1992;12():197-217.
1991: Jon M Huibregtse; Martin Scheffner; Peter M Howley
A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.
The EMBO journal 1991;10(13):4129-35.
1991: Martin Scheffner; K Münger; J C Byrne; Peter M Howley
The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(13):5523-7.
1991: Peter M Howley; K Münger; H Romanczuk; Martin Scheffner; Jon M Huibregtse
Cellular targets of the oncoproteins encoded by the cancer associated human papillomaviruses.
Princess Takamatsu symposia 1991;22():239-48.
1991: Peter M Howley; Martin Scheffner; Jon M Huibregtse; K Münger
Oncoproteins encoded by the cancer-associated human papillomaviruses target the products of the retinoblastoma and p53 tumor suppressor genes.
Cold Spring Harbor symposia on quantitative biology 1991;56():149-55.
1990: Martin Scheffner; B A Werness; Jon M Huibregtse; Arnold J Levine; Peter M Howley
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53.
Cell 1990;63(6):1129-36.