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Klaus Scheffzek

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X Ray Crystallography

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David E Reuss; Klaus Scheffzek; Hans-Peter Berlien; Volker Ehemann; Nikola Holtkamp; Victor-Felix Mautner; Jana Mucha; Ute Müller; Michael Platten; Andreas von Deimling
Functional MHC Class II Is Upregulated in Neurofibromin-Deficient Schwann Cells.
Martin H Berryer; Lionel Carmant; Miriam H Beauchamp; Céline Belhumeur; Sylvia Dobrzeniecka; Christine M Eng; Fadi F Hamdan; Helle Hjalgrim; Ladonna Immken; Laura L Klitten; Jean-Claude Lacaille; Jacek Majewski; Jacques L Michaud; Rikke Steensbjerre Møller; Mathilde Neugnot-Cerioli; Zhiyv Niu; Sylvain Palardy; Gayle Simpson Patel; Lysanne Patry; Daniel Rochefort; Guy A Rouleau; Klaus Scheffzek; Jeremy Schwartzentruber; Mark A Tarnopolsky; Niels Tommerup; Yaping Yang; Graziella Di Cristo
Mutations in SYNGAP1 cause intellectual disability, autism, and a specific form of epilepsy by inducing haploinsufficiency.
Klaus Scheffzek; Stefan Welti
Pleckstrin homology (PH) like domains - versatile modules in protein-protein interaction platforms.

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All Publications

2013: David E Reuss; Klaus Scheffzek; Hans-Peter Berlien; Volker Ehemann; Nikola Holtkamp; Victor-Felix Mautner; Jana Mucha; Ute Müller; Michael Platten; Andreas von Deimling
Functional MHC Class II Is Upregulated in Neurofibromin-Deficient Schwann Cells.
The Journal of investigative dermatology 2013;133(5):1372-5.
2013: Martin H Berryer; Lionel Carmant; Miriam H Beauchamp; Céline Belhumeur; Sylvia Dobrzeniecka; Christine M Eng; Fadi F Hamdan; Helle Hjalgrim; Ladonna Immken; Laura L Klitten; Jean-Claude Lacaille; Jacek Majewski; Jacques L Michaud; Rikke Steensbjerre Møller; Mathilde Neugnot-Cerioli; Zhiyv Niu; Sylvain Palardy; Gayle Simpson Patel; Lysanne Patry; Daniel Rochefort; Guy A Rouleau; Klaus Scheffzek; Jeremy Schwartzentruber; Mark A Tarnopolsky; Niels Tommerup; Yaping Yang; Graziella Di Cristo
Mutations in SYNGAP1 cause intellectual disability, autism, and a specific form of epilepsy by inducing haploinsufficiency.
Human mutation 2013;34(2):385-94.
2012: Klaus Scheffzek; Stefan Welti
Pleckstrin homology (PH) like domains - versatile modules in protein-protein interaction platforms.
FEBS letters 2012;586(17):2662-73.
2012: Anna Feldman-Salit; Rüdiger Hell; Michael Hothorn; Esther D Lenherr; Klaus Scheffzek; Christian Throm; Markus Wirtz; Rebecca C Wade
Allosterically gated enzyme dynamics in the cysteine synthase complex regulate cysteine biosynthesis in Arabidopsis thaliana.
Structure (London, England : 1993) 2012;20(2):292-302.
2012: Kevin Mellert; Klaus Scheffzek; Rainer Wittig; Markus Lamla; Dieter Kaufmann
Enhancing endosomal escape of transduced proteins by photochemical internalisation.
PloS one 2012;7(12):e52473.
2012: Erzsébet Ligeti; Stefan Welti; Klaus Scheffzek
Inhibition and termination of physiological responses by GTPase activating proteins.
Physiological reviews 2012;92(1):237-72.
2011: Stefan Welti; Sonja Kühn; Igor D'Angelo; Britta Brügger; Dieter Kaufmann; Klaus Scheffzek
Structural and biochemical consequences of NF1 associated nontruncating mutations in the Sec14-PH module of neurofibromin.
Human mutation 2011;32(2):191-7.
2010: Markus Wirtz; Hannah Birke; Corinna Heeg; Christopher Müller; Fabian Hosp; Christian Throm; Stephan König; Anna Feldman-Salit; Karsten Rippe; Gabriele Petersen; Rebecca C Wade; Vladimir Rybin; Klaus Scheffzek; Rüdiger Hell
Structure and function of the hetero-oligomeric cysteine synthase complex in plants.
The Journal of biological chemistry 2010;285(43):32810-7.
2010: Michael Hothorn; Wim Van den Ende; Willem Lammens; Vladimir Rybin; Klaus Scheffzek
Structural insights into the pH-controlled targeting of plant cell-wall invertase by a specific inhibitor protein.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(40):17427-32.
2009: Achim Brockmeier; Manuel Skopnik; Brigitte Koch; Christian Herrmann; Wolfgang Hengstenberg; Stefan Welti; Klaus Scheffzek
Activity of the Enterococcus faecalis EIIA(gnt) PTS component and its strong interaction with EIIB(gnt).
Biochemical and biophysical research communications 2009;388(4):630-6.
2009: Stefan Reinelt; Brigitte Koch; Michael Hothorn; Wolfgang Hengstenberg; Stefan Welti; Klaus Scheffzek
Structure of the Enterococcus faecalis EIIA(gnt) PTS component.
Biochemical and biophysical research communications 2009;388(4):626-9.
2009: Gyula Timinszky; Susanne Till; Paul O Hassa; Michael Hothorn; Georg Kustatscher; Bianca Nijmeijer; Julien Colombelli; Matthias Altmeyer; Ernst H K Stelzer; Klaus Scheffzek; Michael Hottiger; Andreas G Ladurner
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation.
Nature structural & molecular biology 2009;16(9):923-9.
2009: Lauren T McGillicuddy; Jody A Fromm; Pablo E Hollstein; Sara Kubek; Rameen Beroukhim; Thomas De Raedt; Bryan W Johnson; Sybil M G Williams; Phioanh Nghiemphu; Linda M Liau; Tim F Cloughesy; Paul Mischel; Annabel Parret; Jeanette Seiler; Gerd Moldenhauer; Klaus Scheffzek; Anat O Stemmer-Rachamimov; Charles L Sawyers; Cameron Brennan; Ludwine MESSIAEN; Ingo K Mellinghoff; Karen Cichowski
Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis.
Cancer cell 2009;16(1):44-54.
2009: Fabien Bonneau; Esther D Lenherr; Vladimir Pena; Darren J Hart; Klaus Scheffzek
Solubility survey of fragments of the neurofibromatosis type 1 protein neurofibromin.
Protein expression and purification 2009;65(1):30-7.
2009: Michael Hothorn; Heinz Neumann; Esther D Lenherr; Mark Wehner; Vladimir Rybin; Paul O Hassa; Andreas Uttenweiler; Monique Reinhardt; Andrea Schmidt; Jeanette Seiler; Andreas G Ladurner; Christian Herrmann; Klaus Scheffzek; Andreas Mayer
Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase.
Science (New York, N.Y.) 2009;324(5926):513-6.
2009: Lorenzo Corsini; Michael Hothorn; Gunter Stier; Vladimir Rybin; Klaus Scheffzek; Toby J Gibson; Michael Sattler
Dimerization and protein binding specificity of the U2AF homology motif of the splicing factor Puf60.
The Journal of biological chemistry 2009;284(1):630-9.
2008: Kanchan Anand; Antje Schulte; Karin Vogel-Bachmayr; Klaus Scheffzek; Matthias Geyer
Structural insights into the cyclin T1-Tat-TAR RNA transcription activation complex from EIAV.
Nature structural & molecular biology 2008;15(12):1287-92.
2008: Lorenzo Corsini; Michael Hothorn; Klaus Scheffzek; Michael Sattler; Gunter Stier
Thioredoxin as a fusion tag for carrier-driven crystallization.
Protein science : a publication of the Protein Society 2008;17(12):2070-9.
2008: Tobias Stuwe; Michael Hothorn; erwan lejeune; Vladimir Rybin; Miriam Bortfeld; Klaus Scheffzek; Andreas G Ladurner
The FACT Spt16 "peptidase" domain is a histone H3-H4 binding module.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(26):8884-9.
2008: Roland Gromes; Michael Hothorn; Esther D Lenherr; Vladimir Rybin; Klaus Scheffzek; Thomas Rausch
The redox switch of gamma-glutamylcysteine ligase via a reversible monomer-dimer transition is a mechanism unique to plants.
The Plant journal : for cell and molecular biology 2008;54(6):1063-75.
2008: Marina Cristodero; Bettina Böttcher; Meikel Diepholz; Klaus Scheffzek; Christine Clayton
The Leishmania tarentolae exosome: purification and structural analysis by electron microscopy.
Molecular and biochemical parasitology 2008;159(1):24-9.
2008: Vladimir Pena; Michael Hothorn; Alexander Eberth; Nikolai Kaschau; Annabel Parret; Lothar Gremer; Fabien Bonneau; Mohammad Reza Ahmadian; Klaus Scheffzek
The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction.
EMBO reports 2008;9(4):350-5.
2008: Ellen Denayer; Annabel Parret; Magdalena Chmara; Suzanne Schubbert; Annick Vogels; koenraad devriendt; JP Frijns; Vladimir Rybin; T J L de Ravel; Kevin Shannon; Jan Cools; Klaus Scheffzek; Eric Legius
Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation.
Human mutation 2008;29(2):232-9.
2007: Kanchan Anand; Antje Schulte; Koh Fujinaga; Klaus Scheffzek; Matthias Geyer
Cyclin box structure of the P-TEFb subunit cyclin T1 derived from a fusion complex with EIAV tat.
Journal of molecular biology 2007;370(5):826-36.
2007: Lorenzo Corsini; Sophie Bonnal; Sophie Bonna; Jérôme Basquin; Michael Hothorn; Klaus Scheffzek; Juan Valcárcel; Michael Sattler
U2AF-homology motif interactions are required for alternative splicing regulation by SPF45.
Nature structural & molecular biology 2007;14(7):620-9.
2007: Stefan Welti; Sven Fraterman; Igor D'Angelo; Matthias Wilm; Klaus Scheffzek
The sec14 homology module of neurofibromin binds cellular glycerophospholipids: mass spectrometry and structure of a lipid complex.
Journal of molecular biology 2007;366(2):551-62.
2006: José Antonio Márquez; Stefan Reinelt; Brigitte Koch; Roswitha Engelmann; Wolfgang Hengstenberg; Klaus Scheffzek
Structure of the full-length enzyme I of the phosphoenolpyruvate-dependent sugar phosphotransferase system.
The Journal of biological chemistry 2006;281(43):32508-15.
2006: Michael Hothorn; Andreas Wachter; Roland Gromes; Tobias Stuwe; Thomas Rausch; Klaus Scheffzek
Structural basis for the redox control of plant glutamate cysteine ligase.
The Journal of biological chemistry 2006;281(37):27557-65.
2006: Michael Hothorn; Klaus Scheffzek
Multiple crystal forms of the cell-wall invertase inhibitor from tobacco support high conformational rigidity over a broad pH range.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 6):665-70.
2006: Igor D'Angelo; Stefan Welti; Fabien Bonneau; Klaus Scheffzek
A novel bipartite phospholipid-binding module in the neurofibromatosis type 1 protein.
EMBO reports 2006;7(2):174-9.
2005: Klaus Scheffzek; Mohammad Reza Ahmadian
GTPase activating proteins: structural and functional insights 18 years after discovery.
Cellular and molecular life sciences : CMLS 2005;62(24):3014-38.
2005: Georg Kustatscher; Michael Hothorn; Céline Pugieux; Klaus Scheffzek; Andreas G Ladurner
Splicing regulates NAD metabolite binding to histone macroH2A.
Nature structural & molecular biology 2005;12(7):624-5.
2005: Emmanuel G Reynaud; Miguel Andrade; Fabien Bonneau; Thi Bach Nga Ly; Michael Knop; Klaus Scheffzek; Rainer Pepperkok
Human Lsg1 defines a family of essential GTPases that correlates with the evolution of compartmentalization.
BMC biology 2005;3():21.
2004: Fabien Bonneau; Igor D'Angelo; Stefan Welti; Gunter Stier; Jari Ylänne; Klaus Scheffzek
Expression, purification and preliminary crystallographic characterization of a novel segment from the neurofibromatosis type 1 protein.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 12 Pt 2):2364-7.
2004: Michael Hothorn; Sebastian Wolf; Patrick Aloy; Steffen Greiner; Klaus Scheffzek
Structural insights into the target specificity of plant invertase and pectin methylesterase inhibitory proteins.
The Plant cell 2004;16(12):3437-47.
2004: Michael Hothorn; Igor D'Angelo; José Antonio Márquez; Steffen Greiner; Klaus Scheffzek
The invertase inhibitor Nt-CIF from tobacco: a highly thermostable four-helix bundle with an unusual N-terminal extension.
Journal of molecular biology 2004;335(4):987-95.
2003: Michael Hothorn; Fabien Bonneau; Gunter Stier; Steffen Greiner; Klaus Scheffzek
Bacterial expression, purification and preliminary X-ray crystallographic characterization of the invertase inhibitor Nt-CIF from tobacco.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 12):2279-82.
2003: José A Márquez; C I Edvard Smith; Maxim V Petoukhov; Paola Lo Surdo; Pekka T Mattsson; Marika Knekt; Anna Westlund; Klaus Scheffzek; Matti Saraste; Dmitri I Svergun
Conformation of full-length Bruton tyrosine kinase (Btk) from synchrotron X-ray solution scattering.
The EMBO journal 2003;22(18):4616-24.
2003: Markus C Schlumberger; Andrea Friebel; Gretel Buchwald; Klaus Scheffzek; Alfred Wittinghofer; Wolf-Dietrich Hardt
Amino acids of the bacterial toxin SopE involved in G nucleotide exchange on Cdc42.
The Journal of biological chemistry 2003;278(29):27149-59.
2003: Paola Lo Surdo; Matthew J Bottomley; Michael Sattler; Klaus Scheffzek
Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions.
Molecular endocrinology (Baltimore, Md.) 2003;17(7):1283-95.
2003: Mohammad Reza Ahmadian; Christina Kiel; Patricia Stege; Klaus Scheffzek
Structural fingerprints of the Ras-GTPase activating proteins neurofibromin and p120GAP.
Journal of molecular biology 2003;329(4):699-710.
2003: Bhushan Nagar; Oliver Hantschel; Matthew Adam Young; Klaus Scheffzek; Darren R Veach; William G Bornmann; Bayard Clarkson; Giulio Superti-Furga; John Kuriyan
Structural basis for the autoinhibition of c-Abl tyrosine kinase.
Cell 2003;112(6):859-71.
2002: Michael Stumber; Matthias Geyer; Robert Graf; Hans Robert Kalbitzer; Klaus Scheffzek; Ulrich Haeberlen
Observation of slow dynamic exchange processes in Ras protein crystals by 31P solid state NMR spectroscopy.
Journal of molecular biology 2002;323(5):899-907.
2002: Ivan Mijakovic; Sandrine Poncet; Anne Galinier; Vicente Monedero; Sonia Fieulaine; Joël Janin; Sylvie Nessler; José Antonio Marquez; Klaus Scheffzek; Sonja Hasenbein; Wolfgang Hengstenberg; Josef Deutscher
Pyrophosphate-producing protein dephosphorylation by HPr kinase/phosphorylase: a relic of early life?
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13442-7.
2002: Gretel Buchwald; Andrea Friebel; Jorge E Galán; Wolf-Dietrich Hardt; Alfred Wittinghofer; Klaus Scheffzek
Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE.
The EMBO journal 2002;21(13):3286-95.
2002: Robert B Russell; José Antonio Márquez; Wolfgang Hengstenberg; Klaus Scheffzek
Evolutionary relationship between the bacterial HPr kinase and the ubiquitous PEP-carboxykinase: expanding the P-loop nucleotidyl transferase superfamily.
FEBS letters 2002;517(1-3):1-6.
2002: José Antonio Márquez; Sonja Hasenbein; Brigitte Koch; Sonia Fieulaine; Sylvie Nessler; Robert B Russell; Wolfgang Hengstenberg; Klaus Scheffzek
Structure of the full-length HPr kinase/phosphatase from Staphylococcus xylosus at 1.95 A resolution: Mimicking the product/substrate of the phospho transfer reactions.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3458-63.
2002: F Ralf Bischoff; Klaus Scheffzek; Herwig Ponstingl
How Ran is regulated.
Results and problems in cell differentiation 2002;35():49-66.
2001: Klaus Scheffzek; P Grünewald; Sabine Wohlgemuth; W Kabsch; H Tu; Michael Wigler; Alfred Wittinghofer; Christian Herrmann
The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast.
Structure (London, England : 1993) 2001;9(11):1043-50.
2001: Gretel Buchwald; E Hostinova; M G Rudolph; A Kraemer; A Sickmann; H E Meyer; Klaus Scheffzek; Alfred Wittinghofer
Conformational switch and role of phosphorylation in PAK activation.
Molecular and cellular biology 2001;21(15):5179-89.
2001: Jari Ylänne; Klaus Scheffzek; Paul Young; Matti Saraste
Crystal structure of the alpha-actinin rod reveals an extensive torsional twist.
Structure (London, England : 1993) 2001;9(7):597-604.
2001: Anouk Demunter; Mohammad Reza Ahmadian; Louis Libbrecht; Marguerite Stas; Mathijs Baens; Klaus Scheffzek; Hugo Degreef; Christiane De Wolf-Peeters; Joost J van den Oord
A novel N-ras mutation in malignant melanoma is associated with excellent prognosis.
Cancer research 2001;61(12):4916-22.
2000: Klaus Scheffzek; I Stephan; O N Jensen; Daria Illenberger; Peter Gierschik
The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI.
Nature structural biology 2000;7(2):122-6.
1999: Mohammad Reza Ahmadian; T Zor; D Vogt; W Kabsch; Zvi Selinger; Alfred Wittinghofer; Klaus Scheffzek
Guanosine triphosphatase stimulation of oncogenic Ras mutants.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):7065-70.
1998: Klaus Scheffzek; Mohammad Reza Ahmadian; L Wiesmüller; W Kabsch; Patricia Stege; F Schmitz; Alfred Wittinghofer
Structural analysis of the GAP-related domain from neurofibromin and its implications.
The EMBO journal 1998;17(15):4313-27.
1998: A Klose; Mohammad Reza Ahmadian; Markus Schuelke; Klaus Scheffzek; Sven Hoffmeyer; Andreas Gewies; F Schmitz; Dieter Kaufmann; Hartmut Peters; A Wittinghofer; Peter Nürnberg
Selective disactivation of neurofibromin GAP activity in neurofibromatosis type 1.
Human molecular genetics 1998;7(8):1261-8.
1998: Klaus Scheffzek; Mohammad Reza Ahmadian; Alfred Wittinghofer
GTPase-activating proteins: helping hands to complement an active site.
Trends in biochemical sciences 1998;23(7):257-62.
1997: Mohammad Reza Ahmadian; Patricia Stege; Klaus Scheffzek; Alfred Wittinghofer
Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras.
Nature structural biology 1997;4(9):686-9.
1997: Klaus Scheffzek; Mohammad Reza Ahmadian; W Kabsch; L Wiesmüller; A Lautwein; F Schmitz; Alfred Wittinghofer
The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.
Science (New York, N.Y.) 1997;277(5324):333-8.
1997: Alfred Wittinghofer; Klaus Scheffzek; Mohammad Reza Ahmadian
The interaction of Ras with GTPase-activating proteins.
FEBS letters 1997;410(1):63-7.
1997: T Schweins; Klaus Scheffzek; R Assheuer; Alfred Wittinghofer
The role of the metal ion in the p21ras catalysed GTP-hydrolysis: Mn2+ versus Mg2+.
Journal of molecular biology 1997;266(4):847-56.
1997: Klaus Scheffzek; A Lautwein; A Scherer; S Franken; Alfred Wittinghofer
Crystallization and preliminary X-ray crystallographic study of the Ras-GTPase-activating domain of human p120GAP.
Proteins 1997;27(2):315-8.
1996: Klaus Scheffzek; A Lautwein; W Kabsch; Mohammad Reza Ahmadian; Alfred Wittinghofer
Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras.
Nature 1996;384(6609):591-6.
1996: Klaus Scheffzek; Werner Kliche; L Wiesmüller; Jochen Reinstein
Crystal structure of the complex of UMP/CMP kinase from Dictyostelium discoideum and the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-uridyl) pentaphosphate (UP5A) and Mg2+ at 2.2 A: implications for water-mediated specificity.
Biochemistry 1996;35(30):9716-27.
1995: L Wiesmüller; Klaus Scheffzek; Werner Kliche; Roger S Goody; Alfred Wittinghofer; Jochen Reinstein
Crystallization and preliminary X-ray analysis of UMP/CMP-kinase from Dictyostelium discoideum with the specific bisubstrate inhibitor P1-(adenosine 5')-P5-(uridine 5')-pentaphosphate (UP5A).
FEBS letters 1995;363(1-2):22-4.
1995: Klaus Scheffzek; C Klebe; Karin Fritz-Wolf; W Kabsch; Alfred Wittinghofer
Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form.
Nature 1995;374(6520):378-81.
1995: T Schweins; Matthias Geyer; Klaus Scheffzek; Arieh Warshel; Hans Robert Kalbitzer; Alfred Wittinghofer
Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.
Nature structural biology 1995;2(1):36-44.
1994: Klaus Scheffzek; W Kabsch; Ilme Schlichting; Emil F Pai; A Lautwein; M Frech; A Wittinghoffer; Roger S Goody
Crystallization and preliminary X-ray structure analysis of thermally unstable p21(H-ras) guanosine complexes.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 4):521-6.
1993: S M Franken; Axel J Scheidig; U Krengel; H Rensland; A Lautwein; Matthias Geyer; Klaus Scheffzek; Roger S Goody; Hans Robert Kalbitzer; Emil F Pai
Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras.
Biochemistry 1993;32(33):8411-20.