Claus Scheidereit

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Stilmann Michael; Hinz Michael; Arslan Seda Cöl; Zimmer Anja; Schreiber Valérie; Scheidereit Claus
A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation.
Rehm Armin; Anagnostopoulos Ioannis; Gerlach Kerstin; Broemer Meike; Scheidereit Claus; Jöhrens Korinna; Hübler Michael; Hetzer Roland; Stein Harald; Lipp Martin; Dörken Bernd; Höpken Uta E
Identification of a chemokine receptor profile characteristic for mediastinal large B-cell lymphoma.
Zhang Yuhang; Tomann Philip; Andl Thomas; Gallant Natalie M; Huelsken Joerg; Jerchow Boris; Birchmeier Walter; Paus Ralf; Piccolo Stefano; Mikkola Marja L; Morrisey Edward E; Overbeek Paul A; Scheidereit Claus; Millar Sarah E; Schmidt-Ullrich Ruth
Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction.

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2009: Stilmann Michael; Hinz Michael; Arslan Seda Cöl; Zimmer Anja; Schreiber Valérie; Scheidereit Claus
A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation.
Molecular cell 2009;36(3):365-78.
2009: Rehm Armin; Anagnostopoulos Ioannis; Gerlach Kerstin; Broemer Meike; Scheidereit Claus; Jöhrens Korinna; Hübler Michael; Hetzer Roland; Stein Harald; Lipp Martin; Dörken Bernd; Höpken Uta E
Identification of a chemokine receptor profile characteristic for mediastinal large B-cell lymphoma.
International journal of cancer. Journal international du cancer 2009;125(10):2367-74.
2009: Zhang Yuhang; Tomann Philip; Andl Thomas; Gallant Natalie M; Huelsken Joerg; Jerchow Boris; Birchmeier Walter; Paus Ralf; Piccolo Stefano; Mikkola Marja L; Morrisey Edward E; Overbeek Paul A; Scheidereit Claus; Millar Sarah E; Schmidt-Ullrich Ruth
Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction.
Developmental cell 2009;17(1):49-61.
2007: Oeckinghaus Andrea; Wegener Elmar; Welteke Verena; Ferch Uta; Arslan Seda Cöl; Ruland Jürgen; Scheidereit Claus; Krappmann Daniel
Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation.
The EMBO journal 2007;26(22):4634-45.
2007: Hinz Michael; Broemer Meike; Arslan Seda Cöl; Otto Albrecht; Mueller Eva-Christina; Dettmer Rudolf; Scheidereit Claus
Signal responsiveness of IkappaB kinases is determined by Cdc37-assisted transient interaction with Hsp90.
The Journal of biological chemistry 2007;282(44):32311-9.
2007: Weichert W; Boehm M; Gekeler V; Bahra M; Langrehr J; Neuhaus P; Denkert C; Imre G; Weller C; Hofmann H-P; Niesporek S; Jacob J; Dietel M; Scheidereit C; Kristiansen G
High expression of RelA/p65 is associated with activation of nuclear factor-kappaB-dependent signaling in pancreatic cancer and marks a patient population with poor prognosis.
British journal of cancer 2007;97(4):523-30.
2007: Henke Norbert; Schmidt-Ullrich Ruth; Dechend Ralf; Park Joon-Keun; Qadri Fatimunnisa; Wellner Maren; Obst Michael; Gross Volkmar; Dietz Rainer; Luft Friedrich C; Scheidereit Claus; Muller Dominik N
Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage.
Circulation research 2007;101(3):268-76.
2007: Hinz Michael; Scheidereit Claus
Striking back at the activator: how IkappaB kinase terminates antigen receptor responses.
Science's STKE : signal transduction knowledge environment 2007;2007(384):pe19.
2006: Scheidereit Claus
IkappaB kinase complexes: gateways to NF-kappaB activation and transcription.
Oncogene 2006;25(51):6685-705.
2006: Schmidt-Ullrich Ruth; Tobin Desmond J; Lenhard Diana; Schneider Pascal; Paus Ralf; Scheidereit Claus
NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth.
Development (Cambridge, England) 2006;133(6):1045-57.
2005: Mathas Stephan; Jöhrens Korinna; Joos Stefan; Lietz Andreas; Hummel Franziska; Janz Martin; Jundt Franziska; Anagnostopoulos Ioannis; Bommert Kurt; Lichter Peter; Stein Harald; Scheidereit Claus; Dörken Bernd
Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large-cell, and other peripheral T-cell lymphomas.
Blood 2005;106(13):4287-93.
2005: Freund Christian; Schmidt-Ullrich Ruth; Baurand Anthony; Dunger Sandra; Schneider Wolfgang; Loser Peter; El-Jamali Amina; Dietz Rainer; Scheidereit Claus; Bergmann Martin W
Requirement of nuclear factor-kappaB in angiotensin II- and isoproterenol-induced cardiac hypertrophy in vivo.
Circulation 2005;111(18):2319-25.
2005: Mehrhof Felix B; Schmidt-Ullrich Ruth; Dietz Rainer; Scheidereit Claus
Regulation of vascular smooth muscle cell proliferation: role of NF-kappaB revisited.
Circulation research 2005;96(9):958-64.
2005: Salanova Birgit; Choi Mira; Rolle Susanne; Wellner Maren; Scheidereit Claus; Luft Friedrich C; Kettritz Ralph
The effect of fever-like temperatures on neutrophil signaling.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(7):816-8.
2005: Krappmann Daniel; Scheidereit Claus
A pervasive role of ubiquitin conjugation in activation and termination of IkappaB kinase pathways.
EMBO reports 2005;6(4):321-6.
2004: Krappmann Daniel; Wegener Elmar; Sunami Yoshiaki; Esen Meral; Thiel Andreas; Mordmuller Benjamin; Scheidereit Claus
The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1.
Molecular and cellular biology 2004;24(14):6488-500.
2004: El Jamali Amina; Freund Christian; Rechner Cindy; Scheidereit Claus; Dietz Rainer; Bergmann Martin W
Reoxygenation after severe hypoxia induces cardiomyocyte hypertrophy in vitro: activation of CREB downstream of GSK3beta.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(10):1096-8.
2004: Broemer Meike; Krappmann Daniel; Scheidereit Claus
Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation.
Oncogene 2004;23(31):5378-86.
2004: Ohazama Atsushi; Hu Yinling; Schmidt-Ullrich Ruth; Cao Yixue; Scheidereit Claus; Karin Michael; Sharpe Paul T
A dual role for Ikk alpha in tooth development.
Developmental cell 2004;6(2):219-27.
2003: Choi Mira; Rolle Susanne; Wellner Maren; Cardoso M Cristina; Scheidereit Claus; Luft Friedrich C; Kettritz Ralph
Inhibition of NF-kappaB by a TAT-NEMO-binding domain peptide accelerates constitutive apoptosis and abrogates LPS-delayed neutrophil apoptosis.
Blood 2003;102(6):2259-67.
2003: Mathas Stephan; Lietz Andreas; Janz Martin; Hinz Michael; Jundt Franziska; Scheidereit Claus; Bommert Kurt; Dorken Bernd
Inhibition of NF-kappaB essentially contributes to arsenic-induced apoptosis.
Blood 2003;102(3):1028-34.
2003: Tegethoff Sebastian; Behlke Joachim; Scheidereit Claus
Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation.
Molecular and cellular biology 2003;23(6):2029-41.
2003: Mordmüller Benjamin; Krappmann Daniel; Esen Meral; Wegener Elmar; Scheidereit Claus
Lymphotoxin and lipopolysaccharide induce NF-kappaB-p52 generation by a co-translational mechanism.
EMBO reports 2003;4(1):82-7.
2002: Hinz Michael; Lemke Petra; Anagnostopoulos Ioannis; Hacker Christine; Krappmann Daniel; Mathas Stephan; Dörken Bernd; Zenke Martin; Stein Harald; Scheidereit Claus
Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity.
The Journal of experimental medicine 2002;196(5):605-17.
2002: Mathas Stephan; Hinz Michael; Anagnostopoulos Ioannis; Krappmann Daniel; Lietz Andreas; Jundt Franziska; Bommert Kurt; Mechta-Grigoriou Fatima; Stein Harald; Dörken Bernd; Scheidereit Claus
Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.
The EMBO journal 2002;21(15):4104-13.
2002: Jundt Franziska; Kley Katharina; Anagnostopoulos Ioannis; Schulze Pröbsting Kristina; Greiner Axel; Mathas Stephan; Scheidereit Claus; Wirth Thomas; Stein Harald; Dörken Bernd
Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease.
Blood 2002;99(8):3060-2.
2002: Hawkes Nicola A; Otero Gabriel; Winkler G Sebastiaan; Marshall Nick; Dahmus Michael E; Krappmann Daniel; Scheidereit Claus; Thomas Claire L; Schiavo Giampietro; Erdjument-Bromage Hediye; Tempst Paul; Svejstrup Jesper Q
Purification and characterization of the human elongator complex.
The Journal of biological chemistry 2002;277(4):3047-52.
2001: Schmidt-Ullrich R; Aebischer T; Hülsken J; Birchmeier W; Klemm U; Scheidereit C
Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices.
Development (Cambridge, England) 2001;128(19):3843-53.
2001: Krappmann D; Patke A; Heissmeyer V; Scheidereit C
B-cell receptor- and phorbol ester-induced NF-kappaB and c-Jun N-terminal kinase activation in B cells requires novel protein kinase C's.
Molecular and cellular biology 2001;21(19):6640-50.
2001: Muller D N; Heissmeyer V; Dechend R; Hampich F; Park J K; Fiebeler A; Shagdarsuren E; Theuer J; Elger M; Pilz B; Breu V; Schroer K; Ganten D; Dietz R; Haller H; Scheidereit C; Luft F C
Aspirin inhibits NF-kappaB and protects from angiotensin II-induced organ damage.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(10):1822-4.
2001: Wuchter C; Krappmann D; Cai Z; Ruppert V; Scheidereit C; Dörken B; Ludwig W D; Karawajew L
In vitro susceptibility to TRAIL-induced apoptosis of acute leukemia cells in the context of TRAIL receptor gene expression and constitutive NF-kappa B activity.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(6):921-8.
2001: Hinz M; Löser P; Mathas S; Krappmann D; Dörken B; Scheidereit C
Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.
Blood 2001;97(9):2798-807.
2001: Slaugenhaupt S A; Blumenfeld A; Gill S P; Leyne M; Mull J; Cuajungco M P; Liebert C B; Chadwick B; Idelson M; Reznik L; Robbins C; Makalowska I; Brownstein M; Krappmann D; Scheidereit C; Maayan C; Axelrod F B; Gusella J F
Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia.
American journal of human genetics 2001;68(3):598-605.
2001: Heissmeyer V; Krappmann D; Hatada E N; Scheidereit C
Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha.
Molecular and cellular biology 2001;21(4):1024-35.
2000: Krappmann D; Hatada E N; Tegethoff S; Li J; Klippel A; Giese K; Baeuerle P A; Scheidereit C
The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component.
The Journal of biological chemistry 2000;275(38):29779-87.
2000: Kordes U; Krappmann D; Heissmeyer V; Ludwig W D; Scheidereit C
Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2000;14(3):399-402.
2000: Hatada E N; Krappmann D; Scheidereit C
NF-kappaB and the innate immune response.
Current opinion in immunology 2000;12(1):52-8.
2000: Hatada E N; Chen-Kiang S; Scheidereit C
Interaction and functional interference of C/EBPbeta with octamer factors in immunoglobulin gene transcription.
European journal of immunology 2000;30(1):174-84.
1999: Emmerich F; Meiser M; Hummel M; Demel G; Foss H D; Jundt F; Mathas S; Krappmann D; Scheidereit C; Stein H; Dörken B
Overexpression of I kappa B alpha without inhibition of NF-kappaB activity and mutations in the I kappa B alpha gene in Reed-Sternberg cells.
Blood 1999;94(9):3129-34.
1999: Dechend R; Maass M; Gieffers J; Dietz R; Scheidereit C; Leutz A; Gulba D C
Chlamydia pneumoniae infection of vascular smooth muscle and endothelial cells activates NF-kappaB and induces tissue factor and PAI-1 expression: a potential link to accelerated arteriosclerosis.
Circulation 1999;100(13):1369-73.
1999: Heissmeyer V; Krappmann D; Wulczyn F G; Scheidereit C
NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes.
The EMBO journal 1999;18(17):4766-78.
1999: Dechend R; Hirano F; Lehmann K; Heissmeyer V; Ansieau S; Wulczyn F G; Scheidereit C; Leutz A
The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators.
Oncogene 1999;18(22):3316-23.
1999: Hinz M; Krappmann D; Eichten A; Heder A; Scheidereit C; Strauss M
NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition.
Molecular and cellular biology 1999;19(4):2690-8.
1999: Krappmann D; Emmerich F; Kordes U; Scharschmidt E; Dörken B; Scheidereit C
Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells.
Oncogene 1999;18(4):943-53.
1998: Hirano F; Chung M; Tanaka H; Maruyama N; Makino I; Moore D D; Scheidereit C
Alternative splicing variants of IkappaB beta establish differential NF-kappaB signal responsiveness in human cells.
Molecular and cellular biology 1998;18(5):2596-607.
1998: Wulczyn F G; Krappmann D; Scheidereit C
Signal-dependent degradation of IkappaBalpha is mediated by an inducible destruction box that can be transferred to NF-kappaB, bcl-3 or p53.
Nucleic acids research 1998;26(7):1724-30.
1998: Hirano F; Tanaka H; Hirano Y; Hiramoto M; Handa H; Makino I; Scheidereit C
Functional interference of Sp1 and NF-kappaB through the same DNA binding site.
Molecular and cellular biology 1998;18(3):1266-74.
1997: Krappmann D; Scheidereit C
Regulation of NF-kappa B activity by I kappa B alpha and I kappa B beta stability.
Immunobiology 1997;198(1-3):3-13.
1997: Bargou R C; Emmerich F; Krappmann D; Bommert K; Mapara M Y; Arnold W; Royer H D; Grinstein E; Greiner A; Scheidereit C; Dörken B
Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.
The Journal of clinical investigation 1997;100(12):2961-9.
1997: Pelletier M R; Hatada E N; Scholz G; Scheidereit C
Efficient transcription of an immunoglobulin kappa promoter requires specific sequence elements overlapping with and downstream of the transcriptional start site.
Nucleic acids research 1997;25(20):3995-4003.
1996: Krappmann D; Wulczyn F G; Scheidereit C
Different mechanisms control signal-induced degradation and basal turnover of the NF-kappaB inhibitor IkappaB alpha in vivo.
The EMBO journal 1996;15(23):6716-26.
1996: Wulczyn F G; Krappmann D; Scheidereit C
The NF-kappa B/Rel and I kappa B gene families: mediators of immune response and inflammation.
Journal of molecular medicine (Berlin, Germany) 1996;74(12):749-69.
1996: Bargou R C; Leng C; Krappmann D; Emmerich F; Mapara M Y; Bommert K; Royer H D; Scheidereit C; Dörken B
High-level nuclear NF-kappa B and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells.
Blood 1996;87(10):4340-7.
1994: Naumann M; Scheidereit C
Activation of NF-kappa B in vivo is regulated by multiple phosphorylations.
The EMBO journal 1994;13(19):4597-607.
1994: Franke S; Scholz G; Scheidereit C
Identification of novel ubiquitous and cell type-specific factors that specifically recognize immunoglobulin heavy chain and kappa light chain promoters.
The Journal of biological chemistry 1994;269(31):20075-82.
1993: Naumann M; Nieters A; Hatada E N; Scheidereit C
NF-kappa B precursor p100 inhibits nuclear translocation and DNA binding of NF-kappa B/rel-factors.
Oncogene 1993;8(8):2275-81.
1993: Hatada E N; Naumann M; Scheidereit C
Common structural constituents confer I kappa B activity to NF-kappa B p105 and I kappa B/MAD-3.
The EMBO journal 1993;12(7):2781-8.
1993: Naumann M; Wulczyn F G; Scheidereit C
The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B.
The EMBO journal 1993;12(1):213-22.
1992: Wulczyn F G; Naumann M; Scheidereit C
Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B.
Nature 1992;358(6387):597-9.
1992: Hatada E N; Nieters A; Wulczyn F G; Naumann M; Meyer R; Nucifora G; McKeithan T W; Scheidereit C
The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappa B DNA binding.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2489-93.
1991: Misseyanni A; Scheidereit C; Kalff M; Beato M
Neither the endogenous nor a functional steroid hormone receptor binding site transactivate the ribosomal RNA gene promoter in vitro.
The Journal of steroid biochemistry and molecular biology 1991;39(4A):409-18.
1991: Meyer R; Hatada E N; Hohmann H P; Haiker M; Bartsch C; Röthlisberger U; Lahm H W; Schlaeger E J; van Loon A P; Scheidereit C
Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):966-70.
1991: Brüggemeier U; Kalff M; Franke S; Scheidereit C; Beato M
Ubiquitous transcription factor OTF-1 mediates induction of the MMTV promoter through synergistic interaction with hormone receptors.
Cell 1991;64(3):565-72.
1991: Hohmann H P; Remy R; Scheidereit C; van Loon A P
Maintenance of NF-kappa B activity is dependent on protein synthesis and the continuous presence of external stimuli.
Molecular and cellular biology 1991;11(1):259-66.

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