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Harry Scheinin

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Harry Scheinin; Jaakko W Långsjö
Why does bispectral index monitoring not perform better?
Karri T Utriainen; Juhani K Airaksinen; Harri Hakovirta; Hans Y Helenius; J Jalonen; Erkki S Kentala; K Leino; Mikko J Pietilä; Olli Polo; Olli T Raitakari; Tiina M Salo; Harry Scheinin; Timo T Laitio
Unrecognised obstructive sleep apnoea is common in severe peripheral arterial disease.
Nora Hagelberg; Jarmo Hietala; Sargo Aalto; Kjell Någren; Antti Pertovaara; Ullamari Pesonen; Harry Scheinin; Lauri Tuominen; Ilkka K Martikainen
Striatal μ-opioid receptor availability predicts cold pressor pain threshold in healthy human subjects.

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All Publications

2013: Harry Scheinin; Jaakko W Långsjö
Why does bispectral index monitoring not perform better?
Anesthesiology 2013;118(5):1233-4.
2013: Karri T Utriainen; Juhani K Airaksinen; Harri Hakovirta; Hans Y Helenius; J Jalonen; Erkki S Kentala; K Leino; Mikko J Pietilä; Olli Polo; Olli T Raitakari; Tiina M Salo; Harry Scheinin; Timo T Laitio
Unrecognised obstructive sleep apnoea is common in severe peripheral arterial disease.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2013;41(3):616-20.
2012: Nora Hagelberg; Jarmo Hietala; Sargo Aalto; Kjell Någren; Antti Pertovaara; Ullamari Pesonen; Harry Scheinin; Lauri Tuominen; Ilkka K Martikainen
Striatal μ-opioid receptor availability predicts cold pressor pain threshold in healthy human subjects.
Neuroscience letters 2012;521(1):11-4.
2012: Jaakko W Långsjö; Anu Maksimow; Antti Revonsuo; Sargo Aalto; Riku Aantaa; Michael T Alkire; Hiroki Hayama; Satu K Jääskeläinen; Kaike K Kaisti; Kimmo Kaskinoro; Harry Scheinin
Returning from oblivion: imaging the neural core of consciousness.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(14):4935-43.
2011: Valdas Noreika; Harry Scheinin; Katja Valli; Riku Aantaa; Leila Jylhänkangas; Kimmo Kaskinoro; Levente Móró; Antti Revonsuo
Consciousness lost and found: subjective experiences in an unresponsive state.
Brain and cognition 2011;77(3):327-34.
2011: K Kaskinoro; Jaakko W Långsjö; Anu Maksimow; Mika O K Särkelä; Riku Aantaa; Satu Jääskeläinen; Kaike K Kaisti; Harry Scheinin
Wide inter-individual variability of bispectral index and spectral entropy at loss of consciousness during increasing concentrations of dexmedetomidine, propofol, and sevoflurane.
British journal of anaesthesia 2011;107(4):573-80.
2009: Mika M Hirvonen; Ville Lumme; Jussi Hirvonen; Ullamari Pesonen; Kjell Någren; Tero Vahlberg; Harry Scheinin; Jarmo Hietala
C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo.
Progress in neuro-psychopharmacology & biological psychiatry 2009;33(4):630-6.
2009: Sargo Aalto; Jussi Hirvonen; Valtteri Kaasinen; Nora Hagelberg; Jaana Kajander; Kjell Någren; Timo Seppälä; Juha O Rinne; Harry Scheinin; Jarmo Hietala
The effects of d-amphetamine on extrastriatal dopamine D2/D3 receptors: a randomized, double-blind, placebo-controlled PET study with [11C]FLB 457 in healthy subjects.
European journal of nuclear medicine and molecular imaging 2009;36(3):475-83.
2009: Ruut M Laitio; Jaakko W Långsjö; Sargo Aalto; Kaike K Kaisti; Elina Salmi; Anu Maksimow; Riku Aantaa; Vesa Oikonen; Tapio Viljanen; Riitta Parkkola; Harry Scheinin
The effects of xenon anesthesia on the relationship between cerebral glucose metabolism and blood flow in healthy subjects: a positron emission tomography study.
Anesthesia and analgesia 2009;108(2):593-600.
2009: Jussi Hirvonen; Sargo Aalto; Nora Hagelberg; Anu Maksimow; Kimmo Ingman; Vesa Oikonen; Jussi Virkkala; Kjell Någren; Harry Scheinin
Measurement of central mu-opioid receptor binding in vivo with PET and [11C]carfentanil: a test-retest study in healthy subjects.
European journal of nuclear medicine and molecular imaging 2009;36(2):275-86.
2008: Elina Salmi; Sargo Aalto; Jussi Hirvonen; Jaakko W Långsjö; Anu Maksimow; Vesa Oikonen; Liisa Metsähonkala; Jussi Virkkala; Kjell Någren; Harry Scheinin
Measurement of GABAA receptor binding in vivo with [11C]flumazenil: a test-retest study in healthy subjects.
NeuroImage 2008;41(2):260-9.
2008: Eero Huupponen; Anu Maksimow; P Lapinlampi; Mika O K Särkelä; Antti Saastamoinen; Amir Snapir; Harry Scheinin; Mika Scheinin; P Meriläinen; Sari-Leena Himanen; Satu Jääskeläinen
Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep.
Acta anaesthesiologica Scandinavica 2008;52(2):289-94.
2008: Elina Salmi; Ruut M Laitio; Sargo Aalto; Anu Maksimow; Jaakko W Långsjö; Kaike K Kaisti; Riku Aantaa; Vesa Oikonen; Liisa Metsähonkala; Kjell Någren; Esa R Korpi; Harry Scheinin
Xenon does not affect gamma-aminobutyric acid type A receptor binding in humans.
Anesthesia and analgesia 2008;106(1):129-34, table of contents.
2008: Ruut M Laitio; Kimmo Kaskinoro; Mika O K Särkelä; Kaike K Kaisti; Elina Salmi; Anu Maksimow; Jaakko W Långsjö; Riku Aantaa; Katja Kangas; Satu Jääskeläinen; Harry Scheinin
Bispectral index, entropy, and quantitative electroencephalogram during single-agent xenon anesthesia.
Anesthesiology 2008;108(1):63-70.
2007: Timo T Laitio; Jouko Jalonen; Tom Kuusela; Harry Scheinin
The role of heart rate variability in risk stratification for adverse postoperative cardiac events.
Anesthesia and analgesia 2007;105(6):1548-60.
2007: Martti Silvanto; Edward Munsterhjelm; S Savolainen; P Tiainen; Tomi T Niemi; Olavi Ylikorkala; Harry Scheinin; K T Olkkola
Effect of 3 g of intravenous paracetamol on post-operative analgesia, platelet function and liver enzymes in patients undergoing tonsillectomy under local anaesthesia.
Acta anaesthesiologica Scandinavica 2007;51(9):1147-54.
2007: M Mäenpää; Jani Penttilä; Timo T Laitio; Kaike K Kaisti; T Kuusela; Susanna Hinkka; Harry Scheinin
The effects of surgical levels of sevoflurane and propofol anaesthesia on heart rate variability.
European journal of anaesthesiology 2007;24(7):626-33.
2007: Ruut M Laitio; Kaike K Kaisti; Jaakko W Låangsjö; Sargo Aalto; Elina Salmi; Anu Maksimow; Riku Aantaa; Vesa Oikonen; Hannu Sipilä; Riitta Parkkola; Harry Scheinin
Effects of xenon anesthesia on cerebral blood flow in humans: a positron emission tomography study.
Anesthesiology 2007;106(6):1128-33.
2007: Anu Maksimow; Amir Snapir; Mika O K Särkelä; Erkki Kentala; Juha W Koskenvuo; Jussi Posti; Satu Jääskeläinen; S Hinkka-Yli-Salomäki; Mika Scheinin; Harry Scheinin
Assessing the depth of dexmedetomidine-induced sedation with electroencephalogram (EEG)-based spectral entropy.
Acta anaesthesiologica Scandinavica 2007;51(1):22-30.
2006: Amir Snapir; Jussi Posti; Erkki Kentala; Juha W Koskenvuo; Jan Sundell; Helena Tuunanen; Kristo Hakala; Harry Scheinin; Juhani Knuuti; Mika Scheinin
Effects of low and high plasma concentrations of dexmedetomidine on myocardial perfusion and cardiac function in healthy male subjects.
Anesthesiology 2006;105(5):902-10; quiz 1069-70.
2006: Anu Maksimow; Mika O K Särkelä; Jaakko W Långsjö; Elina Salmi; Kaike K Kaisti; A Yli-Hankala; S Hinkka-Yli-Salomäki; Harry Scheinin; Satu Jääskeläinen
Increase in high frequency EEG activity explains the poor performance of EEG spectral entropy monitor during S-ketamine anesthesia.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2006;117(8):1660-8.
2006: Jani Penttilä; Amir Snapir; Erkki Kentala; Juha W Koskenvuo; Jussi Posti; Mika Scheinin; Harry Scheinin; Tom A Kuusela
Estimation of cardiac output in a pharmacological trial using a simple method based on arterial blood pressure signal waveform: a comparison with pulmonary thermodilution and echocardiographic methods.
European journal of clinical pharmacology 2006;62(6):401-7.
2006: Timo T Laitio; Heikki V Huikuri; Juha W Koskenvuo; Jouko Jalonen; Timo H Mäkikallio; Hans Helenius; Erkki Kentala; Jaakko Hartiala; Harry Scheinin
Long-term alterations of heart rate dynamics after coronary artery bypass graft surgery.
Anesthesia and analgesia 2006;102(4):1026-31.
2005: Kimmo Ingman; Nora Hagelberg; Sargo Aalto; Kjell Någren; Auni Juhakoski; Sakari Karhuvaara; Antero Kallio; Vesa Oikonen; Jarmo Hietala; Harry Scheinin
Prolonged central mu-opioid receptor occupancy after single and repeated nalmefene dosing.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(12):2245-53.
2005: Sargo Aalto; Jouni A Ihalainen; Jussi Hirvonen; Jaana Kajander; Harry Scheinin; Heikki Tanila; Kjell Någren; Harry Vilkman; Lars ´Gustafsson; Erkka Syvälahti; Jarmo Hietala
Cortical glutamate-dopamine interaction and ketamine-induced psychotic symptoms in man.
Psychopharmacology 2005;182(3):375-83.
2005: Jani Penttilä; M Maenpaa; Timo T Laitio; Jaakko W Långsjö; Susanna Hinkka; Harry Scheinin
Sub-anaesthestic doses of ketamine impair cardiac parasympathetic regulation.
European journal of anaesthesiology 2005;22(10):808-10.
2005: Jani Penttilä; Harry Scheinin; Erkka Syvälahti
Measurement of anticholinergic effects of psychotropic drugs in humans.
Pharmacopsychiatry 2005;38(5):187-93.
2005: Jani Penttilä; Tom A Kuusela; Harry Scheinin
Analysis of rapid heart rate variability in the assessment of anticholinergic drug effects in humans.
European journal of clinical pharmacology 2005;61(8):559-65.
2005: Elina Salmi; Jaakko W Långsjö; Sargo Aalto; Kjell Någren; Liisa Metsähonkala; Kaike K Kaisti; Esa R Korpi; Jarmo Hietala; Harry Scheinin
Subanesthetic ketamine does not affect 11C-flumazenil binding in humans.
Anesthesia and analgesia 2005;101(3):722-5, table of contents.
2005: Anu Maksimow; Kaike K Kaisti; Sargo Aalto; M Mäenpää; Satu Jääskeläinen; Susanna Hinkka; S Martens; Mika O K Särkelä; Hanna Viertiö-Oja; Harry Scheinin
Correlation of EEG spectral entropy with regional cerebral blood flow during sevoflurane and propofol anaesthesia.
Anaesthesia 2005;60(9):862-9.
2005: Jaakko W Långsjö; Anu Maksimow; Elina Salmi; Kaike K Kaisti; Sargo Aalto; Vesa Oikonen; Susanna Hinkka; Riku Aantaa; Hannu Sipilä; Tapio Viljanen; Riitta Parkkola; Harry Scheinin
S-ketamine anesthesia increases cerebral blood flow in excess of the metabolic needs in humans.
Anesthesiology 2005;103(2):258-68.
2005: Ilkka K Martikainen; Nora Hagelberg; Heikki Mansikka; Jarmo Hietala; Kjell Någren; Harry Scheinin; Antti Pertovaara
Association of striatal dopamine D2/D3 receptor binding potential with pain but not tactile sensitivity or placebo analgesia.
Neuroscience letters 2005;376(3):149-53.
2005: V E Lund; Erkki Kentala; Harry Scheinin; K Lertola; Jorma Klossner; K Aitasalo; K Sariola-Heinonen; J Jalonen
Effect of age and repeated hyperbaric oxygen treatments on vagal tone.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc 2005;32(2):111-9.
2004: Elina Salmi; Kaike K Kaisti; Liisa Metsähonkala; Vesa Oikonen; Sargo Aalto; Kjell Någren; Susanna Hinkka; Jarmo Hietala; Esa R Korpi; Harry Scheinin
Sevoflurane and propofol increase 11C-flumazenil binding to gamma-aminobutyric acidA receptors in humans.
Anesthesia and analgesia 2004;99(5):1420-6; table of contents.
2004: Nora Hagelberg; Satu Jääskeläinen; Ilkka K Martikainen; Heikki Mansikka; Heli Forssell; Harry Scheinin; Jarmo Hietala; Antti Pertovaara
Striatal dopamine D2 receptors in modulation of pain in humans: a review.
European journal of pharmacology 2004;500(1-3):187-92.
2004: Antti Pertovaara; Ilkka K Martikainen; Nora Hagelberg; Heikki Mansikka; Kjell Någren; Jarmo Hietala; Harry Scheinin
Striatal dopamine D2/D3 receptor availability correlates with individual response characteristics to pain.
The European journal of neuroscience 2004;20(6):1587-92.
2004: Jani Penttilä; Timo J Kaila; Antti Helminen; Markku Anttila; Sakari Karhuvaara; Sakke Huhtala; Harry Scheinin
Effects of atipamezole--a selective alpha-adrenoceptor antagonist--on cardiac parasympathetic regulation in human subjects.
Autonomic & autacoid pharmacology 2004;24(3):69-75.
2004: Kaike K Kaisti; Jukka Mäkitalo; Hannu Sipilä; Mika Teräs; Harry Scheinin
Ventilator add-on for delivering PET tracer gases.
Journal of nuclear medicine technology 2004;32(2):79-82.
2004: Jani Penttilä; Antti Helminen; Markku Anttila; Susanna Hinkka; Harry Scheinin
Cardiovascular and parasympathetic effects of dexmedetomidine in healthy subjects.
Canadian journal of physiology and pharmacology 2004;82(5):359-62.
2004: Jaakko W Långsjö; Elina Salmi; Kaike K Kaisti; Sargo Aalto; Susanna Hinkka; Riku Aantaa; Vesa Oikonen; Tapio Viljanen; Timo Kurki; Martti Silvanto; Harry Scheinin
Effects of subanesthetic ketamine on regional cerebral glucose metabolism in humans.
Anesthesiology 2004;100(5):1065-71.
2004: Timo T Laitio; Heikki V Huikuri; Timo H Mäkikallio; Jouko Jalonen; Erkki Kentala; Hans Helenius; Olar Pullisaar; Jaakko Hartiala; Harry Scheinin
The breakdown of fractal heart rate dynamics predicts prolonged postoperative myocardial ischemia.
Anesthesia and analgesia 2004;98(5):1239-44, table of contents.
2004: Nora Hagelberg; Sargo Aalto; Jaana Kajander; Vesa Oikonen; Susanna Hinkka; Kjell Någren; Jarmo Hietala; Harry Scheinin
Alfentanil increases cortical dopamine D2/D3 receptor binding in healthy subjects.
Pain 2004;109(1-2):86-93.
2004: Kari Laine; Steven De Bruyn; Harry Björklund; Juha Rouru; Jutta Hänninen; Harry Scheinin; Markku Anttila
Effect of the novel anxiolytic drug deramciclane on cytochrome P(450) 2D6 activity as measured by desipramine pharmacokinetics.
European journal of clinical pharmacology 2004;59(12):893-8.
2003: Markku Anttila; Jani Penttilä; Antti Helminen; Lauri Vuorilehto; Harry Scheinin
Bioavailability of dexmedetomidine after extravascular doses in healthy subjects.
British journal of clinical pharmacology 2003;56(6):691-3.
2003: Nora Hagelberg; Heli Forssell; Sargo Aalto; Juha O Rinne; Harry Scheinin; Tero Taiminen; Kjell Någren; Olli Eskola; Satu Jääskeläinen
Altered dopamine D2 receptor binding in atypical facial pain.
Pain 2003;106(1-2):43-8.
2003: Satu Jääskeläinen; Kaike K Kaisti; L Suni; Susanna Hinkka; Harry Scheinin
Sevoflurane is epileptogenic in healthy subjects at surgical levels of anesthesia.
Neurology 2003;61(8):1073-8.
2003: Jaakko W Långsjö; Kaike K Kaisti; Sargo Aalto; Susanna Hinkka; Riku Aantaa; Vesa Oikonen; Hannu Sipilä; Timo Kurki; Martti Silvanto; Harry Scheinin
Effects of subanesthetic doses of ketamine on regional cerebral blood flow, oxygen consumption, and blood volume in humans.
Anesthesiology 2003;99(3):614-23.
2003: Kaike K Kaisti; Jaakko W Långsjö; Sargo Aalto; Vesa Oikonen; Hannu Sipilä; Mika Teräs; Susanna Hinkka; Liisa Metsähonkala; Harry Scheinin
Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humans.
Anesthesiology 2003;99(3):603-13.
2003: Jani Penttilä; Antti Helminen; Tuomas Jartti; Tom A Kuusela; Heikki V Huikuri; Mikko P Tulppo; Harry Scheinin
Effect of cardiac vagal outflow on complexity and fractal correlation properties of heart rate dynamics.
Autonomic & autacoid pharmacology 2003;23(3):173-9.
2003: V Lund; J Laine; Timo T Laitio; Erkki Kentala; J Jalonen; Harry Scheinin
Instantaneous beat-to-beat variability reflects vagal tone during hyperbaric hyperoxia.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc 2003;30(1):29-36.
2003: Nora Hagelberg; Heli Forssell; Juha O Rinne; Harry Scheinin; Tero Taiminen; Sargo Aalto; Sinikka Luutonen; Kjell Någren; Satu Jääskeläinen
Striatal dopamine D1 and D2 receptors in burning mouth syndrome.
Pain 2003;101(1-2):149-54.
2002: Sargo Aalto; Jussi Hirvonen; Jaana Kajander; Harry Scheinin; Kjell Någren; Harry Vilkman; Lars ´Gustafsson; Erkka Syvälahti; Jarmo Hietala
Ketamine does not decrease striatal dopamine D2 receptor binding in man.
Psychopharmacology 2002;164(4):401-6.
2002: Nora Hagelberg; Ilkka K Martikainen; Heikki Mansikka; Susanna Hinkka; Kjell Någren; Jarmo Hietala; Harry Scheinin; Antti Pertovaara
Dopamine D2 receptor binding in the human brain is associated with the response to painful stimulation and pain modulatory capacity.
Pain 2002;99(1-2):273-9.
2002: Nora Hagelberg; Jaana Kajander; Kjell Någren; Susanna Hinkka; Jarmo Hietala; Harry Scheinin
Mu-receptor agonism with alfentanil increases striatal dopamine D2 receptor binding in man.
Synapse (New York, N.Y.) 2002;45(1):25-30.
2002: Kaike K Kaisti; Liisa Metsähonkala; Mika Teräs; Vesa Oikonen; Sargo Aalto; Satu Jääskeläinen; Susanna Hinkka; Harry Scheinin
Effects of surgical levels of propofol and sevoflurane anesthesia on cerebral blood flow in healthy subjects studied with positron emission tomography.
Anesthesiology 2002;96(6):1358-70.
2002: Timo T Laitio; Timo H Mäkikallio; Heikki V Huikuri; Erkki Kentala; Pekka Uotila; Jouko R Jalonen; Hans Helenius; Jaakko Hartiala; Sinikka Yli-Mäyry; Harry Scheinin
Relation of heart rate dynamics to the occurrence of myocardial ischemia after coronary artery bypass grafting.
The American journal of cardiology 2002;89(10):1176-81.
2001: Outi Ahokoski; Kerttu Irjala; Mikko O Taalikka; P Manninen; Kaija Halonen; Lauri Kangas; Eeva Salminen; Risto Huupponen; Harry Scheinin
Pharmacokinetics of finrozole (MPV-2213ad), a novel selective aromatase inhibitor, in healthy men.
British journal of clinical pharmacology 2001;52(6):702-4.
2001: Jani Penttilä; Antti Helminen; K Luomala; Harry Scheinin
Pharmacokinetic-pharmacodynamic model for the anticholinergic effect of glycopyrrolate.
European journal of clinical pharmacology 2001;57(2):153-8.
2001: Jani Penttilä; Antti Helminen; Tuomas Jartti; Tom A Kuusela; Heikki V Huikuri; Mikko P Tulppo; Rene Coffeng; Harry Scheinin
Time domain, geometrical and frequency domain analysis of cardiac vagal outflow: effects of various respiratory patterns.
Clinical physiology (Oxford, England) 2001;21(3):365-76.
2001: Jani Penttilä; Risto Vesalainen; Antti Helminen; Tom A Kuusela; Susanna Hinkka; K Rahi; Timo J Kaila; Harry Scheinin
Spontaneous baroreflex sensitivity as a dynamic measure of cardiac anticholinergic drug effect.
Journal of autonomic pharmacology 2001;21(2):71-8.
2001: Jani Penttilä; Erkka Syvälahti; Susanna Hinkka; Tom A Kuusela; Harry Scheinin
The effects of amitriptyline, citalopram and reboxetine on autonomic nervous system. A randomised placebo-controlled study on healthy volunteers.
Psychopharmacology 2001;154(4):343-9.
2000: V Lund; Erkki Kentala; Harry Scheinin; Jorma Klossner; K Sariola-Heinonen; J Jalonen
Hyperbaric oxygen increases parasympathetic activity in professional divers.
Acta physiologica Scandinavica 2000;170(1):39-44.
2000: Timo T Laitio; Heikki V Huikuri; Erkki Kentala; Timo H Mäkikallio; Jouko Jalonen; Hans Helenius; K Sariola-Heinonen; Sinikka Yli-Mäyry; Harry Scheinin
Correlation properties and complexity of perioperative RR-interval dynamics in coronary artery bypass surgery patients.
Anesthesiology 2000;93(1):69-80.
2000: V Luukkaa; Juha Rouru; Outi Ahokoski; Harry Scheinin; Kerttu Irjala; Risto Huupponen
Acute inhibition of oestrogen biosynthesis does not affect serum leptin levels in young men.
European journal of endocrinology / European Federation of Endocrine Societies 2000;142(2):164-9.
1999: Kaike K Kaisti; Satu Jääskeläinen; J O Rinne; Liisa Metsähonkala; Harry Scheinin
Epileptiform discharges during 2 MAC sevoflurane anesthesia in two healthy volunteers.
Anesthesiology 1999;91(6):1952-5.
1999: V E Lund; Erkki Kentala; Harry Scheinin; Jorma Klossner; H Helenius; K Sariola-Heinonen; J Jalonen
Heart rate variability in healthy volunteers during normobaric and hyperbaric hyperoxia.
Acta physiologica Scandinavica 1999;167(1):29-35.
1999: Outi Ahokoski; Arja Virtanen; Veli Kairisto; Harry Scheinin; Risto Huupponen; Kerttu Irjala
Biological day-to-day variation and reference change limits of serum cortisol and aldosterone in healthy young men on unrestricted diets.
Clinical chemistry 1999;45(7):1097-9.
1999: Harry Scheinin; Antti Helminen; Sakke Huhtala; PE Grönroos; Jos Bosch; Tom A Kuusela; Jussi Kanto; Timo J Kaila
Spectral analysis of heart rate variability as a quantitative measure of parasympatholytic effect--integrated pharmacokinetics and pharmacodynamics of three anticholinergic drugs.
Therapeutic drug monitoring 1999;21(2):141-51.
1999: Outi Ahokoski; Kerttu Irjala; Sakke Huhtala; Eeva Salminen; Harry Scheinin; Risto Huupponen
A double-blind study of MPV-2213ad, a novel aromatase inhibitor, in healthy male subjects.
European journal of clinical pharmacology 1999;55(1):27-34.
1999: V Lund; Erkki Kentala; Harry Scheinin; Jorma Klossner; P Koskinen; J Jalonen
Effect of hyperbaric conditions on plasma stress hormone levels and endothelin-1.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc 1999;26(2):87-92.
1998: Harry Scheinin; Riku Aantaa; Markku Anttila; P Hakola; Antti Helminen; Sakari Karhuvaara
Reversal of the sedative and sympatholytic effects of dexmedetomidine with a specific alpha2-adrenoceptor antagonist atipamezole: a pharmacodynamic and kinetic study in healthy volunteers.
Anesthesiology 1998;89(3):574-84.
1998: Outi Ahokoski; Arja Virtanen; Risto Huupponen; Harry Scheinin; Eeva Salminen; Veli Kairisto; Kerttu Irjala
Biological day-to-day variation and daytime changes of testosterone, follitropin, lutropin and oestradiol-17beta in healthy men.
Clinical chemistry and laboratory medicine : CCLM / FESCC 1998;36(7):485-91.
1998: T Tallila; O Polo; Riku Aantaa; M Lepistö; A Lahdenperä; Harry Scheinin
Nocturnal body movements and hypoxemia in middle-aged females after lower abdominal surgery under general anesthesia: a study with the static-charge-sensitive bed (SCSB).
Journal of clinical monitoring and computing 1998;14(4):239-44.
1998: Olli A Kirvelä; J Jaatinen; Harry Scheinin; Jussi Kanto
The effects of branched chain amino acid infusion on pain perception and plasma concentrations of monoamines.
Pharmacology, biochemistry, and behavior 1998;60(1):77-82.
1998: Erkki Kentala; Harry Scheinin; Timo J Kaila; T Seppälä; Jussi Kanto
Pharmacokinetics and clinical effects of intramuscular scopolamine plus morphine. A comparison of two injection sites.
Acta anaesthesiologica Scandinavica 1998;42(3):323-8.
1998: Outi Ahokoski; Kerttu Irjala; Risto Huupponen; Kaija Halonen; Eeva Salminen; Harry Scheinin
Hormonal effects of MPV-2213ad, a new selective aromatase inhibitor, in healthy male subjects. A phase I study.
British journal of clinical pharmacology 1998;45(2):141-6.
1997: PE Grönroos; Kerttu Irjala; Risto Huupponen; Harry Scheinin; J Forsström; JJ Forsström
A medication database--a tool for detecting drug interactions in hospital.
European journal of clinical pharmacology 1997;53(1):13-7.
1995: Risto Huupponen; S Karhuvaara; Markku Anttila; L Vuorilehto; Harry Scheinin
Buccal delivery of an alpha 2-adrenergic receptor antagonist, atipamezole, in humans.
Clinical pharmacology and therapeutics 1995;58(5):506-11.
1994: Harry Scheinin; T Havia; E Pekkala; P Huovinen; Jorma Klossner; H Lehto; Juha H A Niinikoski
Aspoxicillin versus piperacillin in severe abdominal infections--a comparative phase III study.
The Journal of antimicrobial chemotherapy 1994;34(5):813-7.
1994: M Virkkilä; T Ali-Melkkilä; Jussi Kanto; J Turunen; Harry Scheinin
Dexmedetomidine as intramuscular premedication for day-case cataract surgery. A comparative study of dexmedetomidine, midazolam and placebo.
Anaesthesia 1994;49(10):853-8.
1994: M L Jaakola; Jussi Kanto; Harry Scheinin; A Kallio
Intramuscular dexmedetomidine premedication--an alternative to midazolam-fentanyl-combination in elective hysterectomy?
Acta anaesthesiologica Scandinavica 1994;38(3):238-43.
1993: Harry Scheinin; M L Jaakola; S Sjövall; T Ali-Melkkilä; S Kaukinen; J Turunen; Jussi Kanto
Intramuscular dexmedetomidine as premedication for general anesthesia. A comparative multicenter study.
Anesthesiology 1993;78(6):1065-75.
1993: M Virkkilä; T Ali-Melkkilä; Jussi Kanto; J Turunen; Harry Scheinin
Dexmedetomidine as intramuscular premedication in outpatient cataract surgery. A placebo-controlled dose-ranging study.
Anaesthesia 1993;48(6):482-7.
1993: Markku Koulu; Ullamari Pesonen; S Koskinen; Harry Scheinin; Raine Virtanen; Mika Scheinin
Reduced turnover of dopamine and 5-hydroxytryptamine in discrete dopaminergic, noradrenergic and serotonergic rat brain areas after acutely administered medetomidine, a selective alpha 2-adrenoceptor agonist.
Pharmacology & toxicology 1993;72(3):182-7.
1992: Harry Scheinin; S Karhuvaara; K T Olkkola; A Kallio; Markku Anttila; L Vuorilehto; Mika Scheinin
Pharmacodynamics and pharmacokinetics of intramuscular dexmedetomidine.
Clinical pharmacology and therapeutics 1992;52(5):537-46.
1992: M L Jaakola; T Ali-Melkkilä; Jussi Kanto; A Kallio; Harry Scheinin; Mika Scheinin
Dexmedetomidine reduces intraocular pressure, intubation responses and anaesthetic requirements in patients undergoing ophthalmic surgery.
British journal of anaesthesia 1992;68(6):570-5.
1991: E MacDonald; Mika Scheinin; Harry Scheinin; Raine Virtanen
Comparison of the behavioral and neurochemical effects of the two optical enantiomers of medetomidine, a selective alpha-2-adrenoceptor agonist.
The Journal of pharmacology and experimental therapeutics 1991;259(2):848-54.
1991: M L Jaakola; M Salonen; R Lehtinen; Harry Scheinin
The analgesic action of dexmedetomidine--a novel alpha 2-adrenoceptor agonist--in healthy volunteers.
Pain 1991;46(3):281-5.
1990: Mika Scheinin; Harry Scheinin; Ulla Ekblad; Jussi Kanto
Biological correlates of mental stress related to anticipated caesarean section.
Acta anaesthesiologica Scandinavica 1990;34(8):640-4.
1990: Riku Aantaa; Jussi Kanto; Mika Scheinin; A Kallio; Harry Scheinin
Dexmedetomidine, an alpha 2-adrenoceptor agonist, reduces anesthetic requirements for patients undergoing minor gynecologic surgery.
Anesthesiology 1990;73(2):230-5.
1990: S Karhuvaara; A Kallio; Mika Scheinin; Markku Anttila; J S Salonen; Harry Scheinin
Pharmacological effects and pharmacokinetics of atipamezole, a novel alpha 2-adrenoceptor antagonist--a randomized, double-blind cross-over study in healthy male volunteers.
British journal of clinical pharmacology 1990;30(1):97-106.
1990: A Kallio; M Saraste; Mika Scheinin; Jaakko Hartiala; Harry Scheinin
Acute hemodynamic effects of medetomidine and clonidine in healthy volunteers: a noninvasive echocardiographic study.
Journal of cardiovascular pharmacology 1990;16(1):28-33.
1990: A Kallio; M Salonen; Heli Forssell; Harry Scheinin; Mika Scheinin; J Tuominen
Medetomidine premedication in dental surgery--a double-blind cross-over study with a new alpha 2-adrenoceptor agonist.
Acta anaesthesiologica Scandinavica 1990;34(3):171-5.
1990: Riku Aantaa; Jussi Kanto; Mika Scheinin; A M Kallio; Harry Scheinin
Dexmedetomidine premedication for minor gynecologic surgery.
Anesthesia and analgesia 1990;70(4):407-13.
1990: S Karhuvaara; A Kallio; Markku Koulu; Harry Scheinin; Mika Scheinin
No involvement of alpha 2-adrenoceptors in the regulation of basal prolactin secretion in healthy men.
Psychoneuroendocrinology 1990;15(2):125-9.
1989: A Kallio; Mika Scheinin; Markku Koulu; R Ponkilainen; H Ruskoaho; O Viinamäki; Harry Scheinin
Effects of dexmedetomidine, a selective alpha 2-adrenoceptor agonist, on hemodynamic control mechanisms.
Clinical pharmacology and therapeutics 1989;46(1):33-42.
1989: Harry Scheinin; Raine Virtanen; E MacDonald; R Lammintausta; Mika Scheinin
Medetomidine--a novel alpha 2-adrenoceptor agonist: a review of its pharmacodynamic effects.
Progress in neuro-psychopharmacology & biological psychiatry 1989;13(5):635-51.
1988: E MacDonald; Harry Scheinin; Mika Scheinin
Behavioural and neurochemical effects of medetomidine, a novel veterinary sedative.
European journal of pharmacology 1988;158(1-2):119-27.
1988: A Kallio; Markku Koulu; Harry Scheinin; J Viikari; Mika Scheinin
Acute effects of medetomidine, a selective alpha 2-adrenoceptor agonist, on anterior pituitary hormone and cortisol secretion in man.
Acta endocrinologica 1988;119(1):11-5.
1987: Tuula Manner; Jussi Kanto; Harry Scheinin; Mika Scheinin
Meptazinol and pentazocine: plasma catecholamines and other effects in healthy volunteers.
British journal of clinical pharmacology 1987;24(6):689-97.
1987: Tuula Manner; Jussi Kanto; Harry Scheinin; O Viinamäki; Mika Scheinin
Meptazinol and pentazocine: effects on prolactin, growth hormone and vasopressin levels in plasma.
Pharmacology & toxicology 1987;61(5):301-4.
1987: Mika Scheinin; A Kallio; Markku Koulu; J Viikari; Harry Scheinin
Sedative and cardiovascular effects of medetomidine, a novel selective alpha 2-adrenoceptor agonist, in healthy volunteers.
British journal of clinical pharmacology 1987;24(4):443-51.
1987: Harry Scheinin; Mika Scheinin
Monoamine metabolite levels in rat CSF: kinetic studies.
Pharmacology & toxicology 1987;61(3):167-71.
1986: Harry Scheinin; Raine Virtanen
Effects of yohimbine and idazoxan on monoamine metabolites in rat cerebrospinal fluid.
Life sciences 1986;39(16):1439-46.
1986: Harry Scheinin; Raine Virtanen; Mika Scheinin
alpha 2-Adrenoceptor agonists decrease free 3-methoxy-4-hydroxyphenylglycol in rat cerebrospinal fluid.
European journal of pharmacology 1986;123(1):115-21.