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Elizabeth Blackburn

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Imke Listerman; Jason L Lukas; Jie Sun; Francesca S Gazzaniga; Elizabeth H Blackburn
The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis.
Emily G Jacobs; Heather Kenna; Candyce H Kroenke; Jue Lin; Elizabeth H Blackburn; Elissa S Epel; Natalie Rasgon
Accelerated cell aging in female APOE-ε4 carriers: implications for hormone therapy use.
Annaliese K Beery; Joshua S Biddle; Elizabeth H Blackburn; Darlene D Francis; Jue Lin; Elissa S Epel
Chronic stress elevates telomerase activity in rats.

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All Publications

2013: Imke Listerman; Jason L Lukas; Jie Sun; Francesca S Gazzaniga; Elizabeth H Blackburn
The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis.
Cancer research 2013;73(9):2817-28.
2013: Emily G Jacobs; Heather Kenna; Candyce H Kroenke; Jue Lin; Elizabeth H Blackburn; Elissa S Epel; Natalie Rasgon
Accelerated cell aging in female APOE-ε4 carriers: implications for hormone therapy use.
PloS one 2013;8(2):e54713.
2012: Annaliese K Beery; Joshua S Biddle; Elizabeth H Blackburn; Darlene D Francis; Jue Lin; Elissa S Epel
Chronic stress elevates telomerase activity in rats.
Biology letters 2012;8(6):1063-6.
2012: Elizabeth H Blackburn; Elissa S Epel
Telomeres and adversity: Too toxic to ignore.
Nature 2012;490(7419):169-71.
2012: Omer T Njajou; J L Sanders; R Li; M Nalls; Anne B Newman; Elizabeth H Blackburn; Richard M Cawthon; Steven R Cummings; Tamara B Harris; Wen-Chi Hsueh
Shorter telomeres are associated with obesity and weight gain in the elderly.
International journal of obesity (2005) 2012;36(9):1176-9.
2012: Aoife O'Donovan; Eli Puterman; A Janet Tomiyama; Owen M Wolkowitz; Nancy E Adler; Elizabeth H Blackburn; Margaret Kemeny; Jue Lin; Elissa S Epel
Stress appraisals and cellular aging: a key role for anticipatory threat in the relationship between psychological stress and telomere length.
Brain, behavior, and immunity 2012;26(4):573-9.
2012: Janice Humphreys; Elizabeth H Blackburn; Bruce A Cooper; Elissa S Epel; Jue Lin; Kathryn A Lee
Telomere shortening in formerly abused and never abused women.
Biological research for nursing 2012;14(2):115-23.
2012: Owen Wolkowitz; Heather M Burke; M Compagnone; Firdaus S Dhabhar; Elissa S Epel; Jue Lin; Synthia H Mellon; J Craig Nelson; V I Reus; R Rosser; Elizabeth H Blackburn
Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response.
Molecular psychiatry 2012;17(2):164-72.
2011: Elizabeth H Blackburn
Cancer interception.
Cancer prevention research (Philadelphia, Pa.) 2011;4(6):787-92.
2011: Elizabeth H Blackburn; Kathleen Collins
Telomerase: an RNP enzyme synthesizes DNA.
Cold Spring Harbor perspectives in biology 2011;3(5):.
2011: Elizabeth H Blackburn
Walking the walk from genes through telomere maintenance to cancer risk.
Cancer prevention research (Philadelphia, Pa.) 2011;4(4):473-5.
2011: Aric A Prather; Eli Puterman; A Janet Tomiyama; Elissa S Epel; Jeffrey Krauss; Jue Lin; Aoife O'Donovan; Elizabeth H Blackburn
Shorter leukocyte telomere length in midlife women with poor sleep quality.
Journal of aging research 2011;2011():721390.
2011: Aoife O'Donovan; Patricia L Opresko; Matthew S Pantell; Eli Puterman; Susan M Rubin; Suzanne Satterfield; Kristine Yaffe; Hilsa N Ayonayon; Elizabeth H Blackburn; Richard M Cawthon; Firdaus S Dhabhar; Elissa S Epel; Tamara B Harris; Wen-Chi Hsueh; Anne B Newman
Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study.
PloS one 2011;6(5):e19687.
2011: Owen Wolkowitz; Synthia H Mellon; Elissa S Epel; Jue Lin; Firdaus S Dhabhar; Yali Su; Victor I Reus; Rebecca Rosser; Heather M Burke; Eve Kupferman; Mariana Compagnone; J Craig Nelson; Elizabeth H Blackburn
Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings.
PloS one 2011;6(3):e17837.
2010: Tanya L Williams; Daniel L Levy; Saori Maki-Yonekura; Koji Yonekura; Elizabeth H Blackburn
Characterization of the yeast telomere nucleoprotein core: Rap1 binds independently to each recognition site.
The Journal of biological chemistry 2010;285(46):35814-24.
2010: Elizabeth H Blackburn
Telomeres and telomerase: the means to the end (Nobel lecture).
Angewandte Chemie (International ed. in English) 2010;49(41):7405-21.
2010: Bradley A Stohr; Lifeng Xu; Elizabeth H Blackburn
The terminal telomeric DNA sequence determines the mechanism of dysfunctional telomere fusion.
Molecular cell 2010;39(2):307-14.
2010: Elissa S Epel; Jue Lin; Firdaus S Dhabhar; Owen Wolkowitz; E Puterman; Lori Karan; Elizabeth H Blackburn
Dynamics of telomerase activity in response to acute psychological stress.
Brain, behavior, and immunity 2010;24(4):531-9.
2010: Omer T Njajou; Elizabeth H Blackburn; Ludmila Pawlikowska; Massimo Mangino; Coleen M Damcott; Pui-Yan Kwok; Timothy D Spector; Anne B Newman; Tamara B Harris; Steven R Cummings; Richard M Cawthon; Alan R Shuldiner; AM Valdes; Wen-Chi Hsueh
A common variant in the telomerase RNA component is associated with short telomere length.
PloS one 2010;5(9):e13048.
2009: Svetlana Makovets; Elizabeth H Blackburn
DNA damage signalling prevents deleterious telomere addition at DNA breaks.
Nature cell biology 2009;11(11):1383-6.
2009: Omer T Njajou; Wen-Chi Hsueh; Elizabeth H Blackburn; Anne B Newman; Shih-Hsuan Wu; Rongling Li; Eleanor M Simonsick; Tamara M Harris; Steve R Cummings; Richard M Cawthon
Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study.
The journals of gerontology. Series A, Biological sciences and medical sciences 2009;64(8):860-4.
2009: A O'Donovan; J Lin; Firdaus S Dhabhar; Owen Wolkowitz; J M Tillie; Elizabeth H Blackburn; E H Blackburn; E S Epel; J Tillie; O M Wolkowitz; Elissa S Epel
Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women.
Brain, behavior, and immunity 2009;23(4):446-9.
2009: Shang Li; Svetlana Makovets; Tetsuya Matsuguchi; Justin D Blethrow; Kevan M Shokat; Elizabeth H Blackburn
Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression.
Cell 2009;136(1):50-61.
2009: Elissa S Epel; Sharon Stein Merkin; Richard Cawthon; Elizabeth H Blackburn; Nancy E Adler; Mark J Pletcher; Teresa E Seeman
The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men.
Aging 2009;1(1):81-8.
2008: Dean Ornish; Jue Lin; Jennifer Daubenmier; Gerdi Weidner; Elissa Epel; Colleen Kemp; Mark Jesus M Magbanua; Ruth Marlin; Loren Yglecias; Peter R Carroll; Elizabeth H Blackburn
Increased telomerase activity and comprehensive lifestyle changes: a pilot study.
The lancet oncology 2008;9(11):1048-57.
2008: Jeffrey J. Seidel; Carol M Anderson; Elizabeth H Blackburn
A novel Tel1/ATM N-terminal motif, TAN, is essential for telomere length maintenance and a DNA damage response.
Molecular and cellular biology 2008;28(18):5736-46.
2008: Bradley A. Stohr; Elizabeth H Blackburn
ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells.
Cancer research 2008;68(13):5309-17.
2008: Carol M Anderson; Dmitry Korkin; Dana L Smith; Svetlana Makovets; Jeffrey J. Seidel; Andrej Sali; Elizabeth H Blackburn
Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.
Genes & development 2008;22(7):854-9.
2008: Elizabeth H Blackburn
Elizabeth Blackburn: because science is worth it. Interview by Ruth Williams.
The Journal of cell biology 2008;180(6):1056-7.
2008: Xueying Wang; Zvi Kam; Peter M Carlton; Lifeng Xu; John W Sedat; Elizabeth H Blackburn
Rapid telomere motions in live human cells analyzed by highly time-resolved microscopy.
Epigenetics & chromatin 2008;1(1):4.
2008: Svetlana Makovets; Tanya L Williams; Elizabeth H Blackburn
The telotype defines the telomere state in Saccharomyces cerevisiae and is inherited as a dominant non-Mendelian characteristic in cells lacking telomerase.
Genetics 2008;178(1):245-57.
2007: Lifeng Xu; Elizabeth H Blackburn
Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres.
Molecular cell 2007;28(2):315-27.
2007: Omer T Njajou; Richard M Cawthon; Coleen M Damcott; Shih-Hsuan Wu; Sandy Ott; Michael J Garant; Elizabeth H Blackburn; Braxton D Mitchell; Alan R Shuldiner; Wen-Chi Hsueh
Telomere length is paternally inherited and is associated with parental lifespan.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(29):12135-9.
2007: Min Hsu; Michael J. McEachern; Alain T Dandjinou; Yehuda Tzfati; Erica Orr; Elizabeth H Blackburn; Neal F Lue
Telomerase core components protect Candida telomeres from aberrant overhang accumulation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(28):11682-7.
2006: Elizabeth H Blackburn; Carol W Greider; Jack W Szostak
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging.
Nature medicine 2006;12(10):1133-8.
2006: Elizabeth H Blackburn; A Hiess; N Bernhoeft; Maikel C Rheinstädter; W Häussler; Gerard H Lander
Fermi surface topology and the superconducting gap function in UPd2Al3: a neutron spin-echo study.
Physical review letters 2006;97(5):057002.
2006: Sepideh Bagheri; Mehdi Nosrati; Shang Li; Sylvia Fong; Sima Torabian; Javier Rangel; Dan H Moore; Scot Federman; Rebecca R Laposa; Frederick L Baehner; Richard W Sagebiel; James E Cleaver; Christopher Haqq; Robert J Debs; Elizabeth H Blackburn; Mohammed Kashani-Sabet
Genes and pathways downstream of telomerase in melanoma metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(30):11306-11.
2006: Amir Goldkorn; Elizabeth H Blackburn
Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells.
Cancer research 2006;66(11):5763-71.
2006: Elissa S Epel; Jue Lin; Frank H Wilhelm; Owen Wolkowitz; Richard M Cawthon; Nancy E Adler; Christyn Dolbier; Wendy Berry Mendes; Elizabeth H Blackburn
Cell aging in relation to stress arousal and cardiovascular disease risk factors.
Psychoneuroendocrinology 2006;31(3):277-87.
2006: Shang Li; Elizabeth H Blackburn
Expression and suppression of human telomerase RNA.
Cold Spring Harbor symposia on quantitative biology 2006;71():211-5.
2005: Elizabeth H Blackburn
Telomerase and Cancer: Kirk A. Landon--AACR prize for basic cancer research lecture.
Molecular cancer research : MCR 2005;3(9):477-82.
2005: Elizabeth H Blackburn
Cell biology: Shaggy mouse tales.
Nature 2005;436(7053):922-3.
2005: Hinh Ly; Mike Schertzer; Wasil Jastaniah; Jeff Davis; Siu Li Yong; Qin Ouyang; Elizabeth H Blackburn; Tristam PARSLOW; Peter M Lansdorp
Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita.
Blood 2005;106(4):1246-52.
2005: Shang Li; Julia Crothers; Christopher Haqq; Elizabeth H Blackburn
Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA.
The Journal of biological chemistry 2005;280(25):23709-17.
2005: Elizabeth H Blackburn
Telomeres and telomerase: their mechanisms of action and the effects of altering their functions.
FEBS letters 2005;579(4):859-62.
2005: Elizabeth H Blackburn
Stem cell science and politics: a talk with Elizabeth Blackburn.
Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees 2005;14(2):214-7.
2005: Elizabeth H Blackburn
Thoughts of a former Council member.
Perspectives in biology and medicine 2005;48(2):172-80.
2004: Melissa A Rivera; Elizabeth H Blackburn
Processive utilization of the human telomerase template: lack of a requirement for template switching.
The Journal of biological chemistry 2004;279(51):53770-81.
2004: Elissa S Epel; Elizabeth H Blackburn; Jue Lin; Firdaus S Dhabhar; Nancy E Adler; Jason D Morrow; Richard M Cawthon
Accelerated telomere shortening in response to life stress.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(49):17312-5.
2004: Lifeng Xu; Elizabeth H Blackburn
Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules.
The Journal of cell biology 2004;167(5):819-30.
2004: Daniel L. Levy; Elizabeth H Blackburn
Counting of Rif1p and Rif2p on Saccharomyces cerevisiae telomeres regulates telomere length.
Molecular and cellular biology 2004;24(24):10857-67.
2004: Jue Lin; Hinh Ly; Arif Hussain; Mira Abraham; Sivan Pearl; Yehuda Tzfati; Tristam PARSLOW; Elizabeth H Blackburn
A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(41):14713-8.
2004: Mehdi Nosrati; Shang Li; Sepideh Bagheri; David Ginzinger; Elizabeth H Blackburn; Robert J Debs; Mohammed Kashani-Sabet
Antitumor activity of systemically delivered ribozymes targeting murine telomerase RNA.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(15):4983-90.
2004: Shang Li; Jonathan E Rosenberg; Annemarie A Donjacour; Inna L Botchkina; Yun Kit Hom; Gerald R Cunha; Elizabeth H Blackburn
Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA.
Cancer research 2004;64(14):4833-40.
2004: Svetlana Makovets; Ira Herskowitz; Elizabeth H Blackburn
Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions.
Molecular and cellular biology 2004;24(9):4019-31.
2004: Elizabeth H Blackburn
Bioethics and the political distortion of biomedical science.
The New England journal of medicine 2004;350(14):1379-80.
2004: Elizabeth H Blackburn; Janet Rowley
Reason as our guide.
PLoS biology 2004;2(4):E116.
2004: Jue Lin; Dana L Smith; Elizabeth H Blackburn
Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response.
Molecular biology of the cell 2004;15(4):1623-34.
2004: Elizabeth H Blackburn
A 'full range' of bioethical views just got narrower.
Washington post (Washington, D.C. : 1974) 2004;():B2.
2004: Jue Lin; Elizabeth H Blackburn
Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA.
Genes & development 2004;18(4):387-96.
2004: Simon R W L Chan; Elizabeth H Blackburn
Telomeres and telomerase.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2004;359(1441):109-21.
2004: Carol W Greider; Elizabeth H Blackburn
Tracking telomerase.
Cell 2004;116(2 Suppl):S83-6, 1 p following S86.
2003: Anita G Seto; Kfir Umansky; Yehuda Tzfati; Arthur J Zaug; Elizabeth H Blackburn; Thomas R Cech
A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity.
RNA (New York, N.Y.) 2003;9(11):1323-32.
2003: Hinh Ly; Elizabeth H Blackburn; Tristam PARSLOW
Comprehensive structure-function analysis of the core domain of human telomerase RNA.
Molecular and cellular biology 2003;23(19):6849-56.
2003: Moses Kim; Lifeng Xu; Elizabeth H Blackburn
Catalytically active human telomerase mutants with allele-specific biological properties.
Experimental cell research 2003;288(2):277-87.
2003: Yehuda Tzfati; Zachary Knight; Jagoree Roy; Elizabeth H Blackburn
A novel pseudoknot element is essential for the action of a yeast telomerase.
Genes & development 2003;17(14):1779-88.
2003: Simon W-L Chan; Elizabeth H Blackburn
Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining.
Molecular cell 2003;11(5):1379-87.
2003: Hinh Ly; Lifeng Xu; Melissa A Rivera; Tristam PARSLOW; Elizabeth H Blackburn
A role for a novel 'trans-pseudoknot' RNA-RNA interaction in the functional dimerization of human telomerase.
Genes & development 2003;17(9):1078-83.
2003: C D Smith; D L Smith; Joe L DeRisi; Elizabeth H Blackburn
Telomeric protein distributions and remodeling through the cell cycle in Saccharomyces cerevisiae.
Molecular biology of the cell 2003;14(2):556-70.
2002: Luis R Comolli; Ivan Smirnov; Lifeng Xu; Elizabeth H Blackburn; Tom L James
A molecular switch underlies a human telomerase disease.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16998-7003.
2002: Anita G Seto; April J Livengood; Yehuda Tzfati; Elizabeth H Blackburn; Thomas R Cech
A bulged stem tethers Est1p to telomerase RNA in budding yeast.
Genes & development 2002;16(21):2800-12.
2002: Janet D Rowley; Elizabeth H Blackburn; michael gazzaniga; Daniel W Foster
Harmful moratorium on stem cell research.
Science (New York, N.Y.) 2002;297(5589):1957.
2002: Shivani Nautiyal; Joe L DeRisi; Elizabeth H Blackburn
The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9316-21.
2002: Simon W-L Chan; Elizabeth H Blackburn
New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin.
Oncogene 2002;21(4):553-63.
2002: Maria Isabel N Cano; Julie Johnson Blake; Elizabeth H Blackburn; Nina Agabian
A Trypanosoma brucei protein complex that binds G-overhangs and co-purifies with telomerase activity.
The Journal of biological chemistry 2002;277(2):896-906.
2002: Michael J. McEachern; Dana H Underwood; Elizabeth H Blackburn
Dynamics of telomeric DNA turnover in yeast.
Genetics 2002;160(1):63-73.
2001: Elizabeth H Blackburn
Switching and signaling at the telomere.
Cell 2001;106(6):661-73.
2001: S W Chan; J Chang; J Prescott; Elizabeth H Blackburn
Altering telomere structure allows telomerase to act in yeast lacking ATM kinases.
Current biology : CB 2001;11(16):1240-50.
2001: M M Kim; Melissa A Rivera; Inna L Botchkina; Refaat Shalaby; Ann D Thor; Elizabeth H Blackburn
A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(14):7982-7.
2000: Elizabeth H Blackburn
Telomere states and cell fates.
Nature 2000;408(6808):53-6.
2000: Michael J. McEachern; Shilpa Iyer; TB Fulton; Elizabeth H Blackburn
Telomere fusions caused by mutating the terminal region of telomeric DNA.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(21):11409-14.
2000: Elizabeth H Blackburn
The end of the (DNA) line.
Nature structural biology 2000;7(10):847-50.
2000: TL Ware; Haiyang Wang; Elizabeth H Blackburn
Three telomerases with completely non-telomeric template replacements are catalytically active.
The EMBO journal 2000;19(12):3119-31.
2000: Elizabeth H Blackburn
Telomeres and telomerase.
The Keio journal of medicine 2000;49(2):59-65.
2000: Yehuda Tzfati; TB Fulton; Jagoree Roy; Elizabeth H Blackburn
Template boundary in a yeast telomerase specified by RNA structure.
Science (New York, N.Y.) 2000;288(5467):863-7.
2000: J C Prescott; Elizabeth H Blackburn
Telomerase RNA template mutations reveal sequence-specific requirements for the activation and repression of telomerase action at telomeres.
Molecular and cellular biology 2000;20(8):2941-8.
2000: Elizabeth H Blackburn; S Chan; J Chang; TB Fulton; Anat Krauskopf; Michael J. McEachern; Julia Prescott; Jagoree Roy; C Smith; H Wang
Molecular manifestations and molecular determinants of telomere capping.
Cold Spring Harbor symposia on quantitative biology 2000;65():253-63.
2000: Michael J. McEachern; Anat Krauskopf; Elizabeth H Blackburn
Telomeres and their control.
Annual review of genetics 2000;34():331-358.
2000: Elizabeth H Blackburn; David Gilley; TL Ware; A Bhattacharyya; K Kirk; Haiyang Wang
Studying the telomerase RNA in Tetrahymena.
Methods in cell biology 2000;62():417-32.
1999: Hsin Ling Hsu; David Gilley; Elizabeth H Blackburn; David J Chen
Ku is associated with the telomere in mammals.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12454-8.
1999: Elizabeth H Blackburn
The telomere and telomerase: how Do they interact?
The Mount Sinai journal of medicine, New York 1999;66(5-6):292-300.
1999: David Gilley; Elizabeth H Blackburn
The telomerase RNA pseudoknot is critical for the stable assembly of a catalytically active ribonucleoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6621-5.
1999: J C Prescott; Elizabeth H Blackburn
Telomerase: Dr Jekyll or Mr Hyde?
Current opinion in genetics & development 1999;9(3):368-73.
1999: C D Smith; Elizabeth H Blackburn
Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast.
The Journal of cell biology 1999;145(2):203-14.
1999: Jiyue Zhu; H Wang; John M Bishop; Elizabeth H Blackburn
Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3723-8.
1999: Maria Isabel N Cano; Jan Dungan; Nina Agabian; Elizabeth H Blackburn
Telomerase in kinetoplastid parasitic protozoa.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3616-21.
1998: Jagoree Roy; TB Fulton; Elizabeth H Blackburn
Specific telomerase RNA residues distant from the template are essential for telomerase function.
Genes & development 1998;12(20):3286-300.
1998: Anat Krauskopf; Elizabeth H Blackburn
Rap1 protein regulates telomere turnover in yeast.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12486-91.
1998: TB Fulton; Elizabeth H Blackburn
Identification of Kluyveromyces lactis telomerase: discontinuous synthesis along the 30-nucleotide-long templating domain.
Molecular and cellular biology 1998;18(9):4961-70.
1998: P Cohen; Elizabeth H Blackburn
Two types of telomeric chromatin in Tetrahymena thermophila.
Journal of molecular biology 1998;280(3):327-44.
1998: R W Frenck; Elizabeth H Blackburn; Kevin Shannon
The rate of telomere sequence loss in human leukocytes varies with age.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(10):5607-10.
1998: R C Gallagher; Elizabeth H Blackburn
A promoter region mutation affecting replication of the Tetrahymena ribosomal DNA minichromosome.
Molecular and cellular biology 1998;18(5):3021-33.
1998: Y Hiraoka; E Henderson; Elizabeth H Blackburn
Not so peculiar: fission yeast telomere repeats.
Trends in biochemical sciences 1998;23(4):126.
1998: Haiyang Wang; David Gilley; Elizabeth H Blackburn
A novel specificity for the primer-template pairing requirement in Tetrahymena telomerase.
The EMBO journal 1998;17(4):1152-60.
1998: Marita Cohn; Michael J. McEachern; Elizabeth H Blackburn
Telomeric sequence diversity within the genus Saccharomyces.
Current genetics 1998;33(2):83-91.
1997: Elizabeth H Blackburn
The telomere and telomerase: nucleic acid-protein complexes acting in a telomere homeostasis system. A review.
Biochemistry. Biokhimii͡a 1997;62(11):1196-201.
1997: J Prescott; Elizabeth H Blackburn
Functionally interacting telomerase RNAs in the yeast telomerase complex.
Genes & development 1997;11(21):2790-800.
1997: A Bhattacharyya; Elizabeth H Blackburn
A functional telomerase RNA swap in vivo reveals the importance of nontemplate RNA domains.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):2823-7.
1997: A Bhattacharyya; Elizabeth H Blackburn
Aspergillus nidulans maintains short telomeres throughout development.
Nucleic acids research 1997;25(7):1426-31.
1997: K E Kirk; Brian Harmon; I K Reichardt; John W Sedat; Elizabeth H Blackburn
Block in anaphase chromosome separation caused by a telomerase template mutation.
Science (New York, N.Y.) 1997;275(5305):1478-81.
1997: Haiyang Wang; Elizabeth H Blackburn
De novo telomere addition by Tetrahymena telomerase in vitro.
The EMBO journal 1997;16(4):866-79.
1997: J Prescott; Elizabeth H Blackburn
Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro.
Genes & development 1997;11(4):528-40.
1997: Elizabeth H Blackburn; A Bhattacharyya; David Gilley; K Kirk; Anat Krauskopf; Michael J. McEachern; Julia Prescott; TL Ware
The telomere and telomerase: how do they interact?
Ciba Foundation symposium 1997;211():2-13; discussion 15-9.
1996: Anat Krauskopf; Elizabeth H Blackburn
Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats.
Nature 1996;383(6598):354-7.
1996: Michael J. McEachern; Elizabeth H Blackburn
Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase.
Genes & development 1996;10(14):1822-34.
1996: Carol W Greider; Elizabeth H Blackburn
Telomeres, telomerase and cancer.
Scientific American 1996;274(2):92-7.
1996: David Gilley; Elizabeth H Blackburn
Specific RNA residue interactions required for enzymatic functions of Tetrahymena telomerase.
Molecular and cellular biology 1996;16(1):66-75.
1996: C Strahl; Elizabeth H Blackburn
Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines.
Molecular and cellular biology 1996;16(1):53-65.
1995: David Gilley; M S Lee; Elizabeth H Blackburn
Altering specific telomerase RNA template residues affects active site function.
Genes & development 1995;9(18):2214-26.
1995: Michael J. McEachern; Elizabeth H Blackburn
Runaway telomere elongation caused by telomerase RNA gene mutations.
Nature 1995;376(6539):403-9.
1995: M Cohn; Elizabeth H Blackburn
Telomerase in yeast.
Science (New York, N.Y.) 1995;269(5222):396-400.
1995: W J Pan; R C Gallagher; Elizabeth H Blackburn
Replication of an rRNA gene origin plasmid in the Tetrahymena thermophila macronucleus is prevented by transcription through the origin from an RNA polymerase I promoter.
Molecular and cellular biology 1995;15(6):3372-81.
1995: W J Pan; Elizabeth H Blackburn
Tandem repeats of the 5' non-transcribed spacer of Tetrahymena rDNA function as high copy number autonomous replicons in the macronucleus but do not prevent rRNA gene dosage regulation.
Nucleic acids research 1995;23(9):1561-9.
1995: K E Kirk; Elizabeth H Blackburn
An unusual sequence arrangement in the telomeres of the germ-line micronucleus in Tetrahymena thermophila.
Genes & development 1995;9(1):59-71.
1995: Daniel P Romero; Elizabeth H Blackburn
Circular rDNA replicons persist in Tetrahymena thermophila transformants synthesizing GGGGTC telomeric repeats.
The Journal of eukaryotic microbiology 1995;42(1):32-43.
1994: A Bhattacharyya; Elizabeth H Blackburn
Architecture of telomerase RNA.
The EMBO journal 1994;13(23):5721-31.
1994: Elizabeth H Blackburn
Telomeres: no end in sight.
Cell 1994;77(5):621-3.
1994: G M Kapler; E Orias; Elizabeth H Blackburn
Tetrahymena thermophila mutants defective in the developmentally programmed maturation and maintenance of the rDNA minichromosome.
Genetics 1994;137(2):455-66.
1994: Michael J. McEachern; Elizabeth H Blackburn
A conserved sequence motif within the exceptionally diverse telomeric sequences of budding yeasts.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(8):3453-7.
1994: C Strahl; Elizabeth H Blackburn
The effects of nucleoside analogs on telomerase and telomeres in Tetrahymena.
Nucleic acids research 1994;22(6):893-900.
1994: David Gilley; Elizabeth H Blackburn
Lack of telomere shortening during senescence in Paramecium.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(5):1955-8.
1994: D E Shippen; Elizabeth H Blackburn; C M Price
DNA bound by the Oxytricha telomere protein is accessible to telomerase and other DNA polymerases.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(1):405-9.
1994: G M Kapler; Elizabeth H Blackburn
A weak germ-line excision mutation blocks developmentally controlled amplification of the rDNA minichromosome of Tetrahymena thermophila.
Genes & development 1994;8(1):84-95.
1993: M S Lee; Elizabeth H Blackburn
Sequence-specific DNA primer effects on telomerase polymerization activity.
Molecular and cellular biology 1993;13(10):6586-99.
1993: V Lundblad; Elizabeth H Blackburn
An alternative pathway for yeast telomere maintenance rescues est1- senescence.
Cell 1993;73(2):347-60.
1993: M S Lee; R C Gallagher; J Bradley; Elizabeth H Blackburn
In vivo and in vitro studies of telomeres and telomerase.
Cold Spring Harbor symposia on quantitative biology 1993;58():707-18.
1992: Elizabeth H Blackburn
Telomerases.
Annual review of biochemistry 1992;61():113-29.
1991: G L Yu; Elizabeth H Blackburn
Developmentally programmed healing of chromosomes by telomerase in Tetrahymena.
Cell 1991;67(4):823-32.
1991: Daniel P Romero; Elizabeth H Blackburn
A conserved secondary structure for telomerase RNA.
Cell 1991;67(2):343-53.
1991: Elizabeth H Blackburn
Telomeres.
Trends in biochemical sciences 1991;16(10):378-81.
1991: C Wyman; Elizabeth H Blackburn
Tel-1 transposon-like elements of Tetrahymena thermophila are associated with micronuclear genome rearrangements.
Genetics 1991;129(1):57-67.
1991: Elizabeth H Blackburn
Structure and function of telomeres.
Nature 1991;350(6319):569-73.
1990: Elizabeth H Blackburn
RNA editing. Copy editing--what's the U's?
Nature 1990;346(6285):609-10.
1990: Elizabeth H Blackburn
Telomeres and their synthesis.
Science (New York, N.Y.) 1990;249(4968):489-90.
1990: G L Yu; Elizabeth H Blackburn
Amplification of tandemly repeated origin control sequences confers a replication advantage on rDNA replicons in Tetrahymena thermophila.
Molecular and cellular biology 1990;10(5):2070-80.
1990: Elizabeth H Blackburn
Telomeres: structure and synthesis.
The Journal of biological chemistry 1990;265(11):5919-21.
1990: G L Yu; J D Bradley; Laura D Attardi; Elizabeth H Blackburn
In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs.
Nature 1990;344(6262):126-32.
1990: V Lundblad; Elizabeth H Blackburn
RNA-dependent polymerase motifs in EST1: tentative identification of a protein component of an essential yeast telomerase.
Cell 1990;60(4):529-30.
1990: D Shippen-Lentz; Elizabeth H Blackburn
Functional evidence for an RNA template in telomerase.
Science (New York, N.Y.) 1990;247(4942):546-52.
1990: Elizabeth H Blackburn
Cell biology: telomeres sans frontières.
Nature 1990;343(6254):122.
1990: Elizabeth H Blackburn
Telomeres and their synthesis.
Harvey lectures 1990;86():1-18.
1989: G L Yu; Elizabeth H Blackburn
Transformation of Tetrahymena thermophila with a mutated circular ribosomal DNA plasmid vector.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8487-91.
1989: E K Robinson; P D Cohen; Elizabeth H Blackburn
A novel DNA deletion-ligation reaction catalyzed in vitro by a developmentally controlled activity from Tetrahymena cells.
Cell 1989;58(5):887-900.
1989: H L Phan; J Forney; Elizabeth H Blackburn
Analysis of Paramecium macronuclear DNA using pulsed field gel electrophoresis.
The Journal of protozoology 1989;36(4):402-8.
1989: D Shippen-Lentz; Elizabeth H Blackburn
Telomere terminal transferase activity from Euplotes crassus adds large numbers of TTTTGGGG repeats onto telomeric primers.
Molecular and cellular biology 1989;9(6):2761-4.
1989: J Shampay; Elizabeth H Blackburn
Tetrahymena micronuclear sequences that function as telomeres in yeast.
Nucleic acids research 1989;17(8):3247-60.
1989: P C Yaeger; E Orias; W L Shaiu; D D Larson; Elizabeth H Blackburn
The replication advantage of a free linear rRNA gene is restored by somatic recombination in Tetrahymena thermophila.
Molecular and cellular biology 1989;9(2):452-60.
1989: Carol W Greider; Elizabeth H Blackburn
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis.
Nature 1989;337(6205):331-7.
1989: E R Henderson; Elizabeth H Blackburn
An overhanging 3' terminus is a conserved feature of telomeres.
Molecular and cellular biology 1989;9(1):345-8.
1989: Elizabeth H Blackburn; Carol W Greider; E Henderson; M S Lee; J Shampay; D Shippen-Lentz
Recognition and elongation of telomeres by telomerase.
Genome / National Research Council Canada = Génome / Conseil national de recherches Canada 1989;31(2):553-60.
1988: E Orias; D Larson; Yanfen Hu; G L Yu; J Karttunen; A Løvlie; B Haller; Elizabeth H Blackburn
Replacement of the macronuclear ribosomal RNA genes of a mutant Tetrahymena using electroporation.
Gene 1988;70(2):295-301.
1988: G L Yu; M Hasson; Elizabeth H Blackburn
Circular ribosomal DNA plasmids transform Tetrahymena thermophila by homologous recombination with endogenous macronuclear ribosomal DNA.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(14):5151-5.
1988: E A Spangler; T Ryan; Elizabeth H Blackburn
Developmentally regulated telomere addition in Tetrahymena thermophila.
Nucleic acids research 1988;16(12):5569-85.
1988: J D Forney; Elizabeth H Blackburn
Developmentally controlled telomere addition in wild-type and mutant paramecia.
Molecular and cellular biology 1988;8(1):251-8.
1988: J Shampay; Elizabeth H Blackburn
Generation of telomere-length heterogeneity in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(2):534-8.
1987: E Henderson; C C Hardin; S K Walk; Ignacio Tinoco; Elizabeth H Blackburn
Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs.
Cell 1987;51(6):899-908.
1987: Carol W Greider; Elizabeth H Blackburn
The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity.
Cell 1987;51(6):887-98.
1987: J Forney; E R Henderson; Elizabeth H Blackburn
Identification of the telomeric sequence of the acellular slime molds Didymium iridis and Physarum polycephalum.
Nucleic acids research 1987;15(22):9143-52.
1987: D D Larson; E A Spangler; Elizabeth H Blackburn
Dynamics of telomere length variation in Tetrahymena thermophila.
Cell 1987;50(3):477-83.
1986: D D Larson; Elizabeth H Blackburn; P C Yaeger; E Orias
Control of rDNA replication in Tetrahymena involves a cis-acting upstream repeat of a promoter element.
Cell 1986;47(2):229-40.
1986: P B Challoner; Elizabeth H Blackburn
Conservation of sequences adjacent to the telomeric C4A2 repeats of ciliate macronuclear ribosomal RNA gene molecules.
Nucleic acids research 1986;14(15):6299-311.
1986: M L Budarf; Elizabeth H Blackburn
Chromatin structure of the telomeric region and 3'-nontranscribed spacer of Tetrahymena ribosomal RNA genes.
The Journal of biological chemistry 1986;261(1):363-9.
1986: Elizabeth H Blackburn; K M Karrer
Genomic reorganization in ciliated protozoans.
Annual review of genetics 1986;20():501-21.
1985: Carol W Greider; Elizabeth H Blackburn
Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.
Cell 1985;43(2 Pt 1):405-13.
1985: J M Cherry; Elizabeth H Blackburn
The internally located telomeric sequences in the germ-line chromosomes of Tetrahymena are at the ends of transposon-like elements.
Cell 1985;43(3 Pt 2):747-58.
1985: E A Howard; Elizabeth H Blackburn
Reproducible and variable genomic rearrangements occur in the developing somatic nucleus of the ciliate Tetrahymena thermophila.
Molecular and cellular biology 1985;5(8):2039-50.
1985: E A Spangler; Elizabeth H Blackburn
The nucleotide sequence of the 17S ribosomal RNA gene of Tetrahymena thermophila and the identification of point mutations resulting in resistance to the antibiotics paromomycin and hygromycin.
The Journal of biological chemistry 1985;260(10):6334-40.
1985: P J Bruns; Alisa L Katzen; L Martin; Elizabeth H Blackburn
A drug-resistant mutation in the ribosomal DNA of Tetrahymena.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(9):2844-6.
1985: P B Challoner; A A Amin; Ronald E Pearlman; Elizabeth H Blackburn
Conserved arrangements of repeated DNA sequences in nontranscribed spacers of ciliate ribosomal RNA genes: evidence for molecular coevolution.
Nucleic acids research 1985;13(7):2661-80.
1984: J Shampay; J W Szostak; Elizabeth H Blackburn
DNA sequences of telomeres maintained in yeast.
Nature 1984;310(5973):154-7.
1984: Elizabeth H Blackburn
Telomeres: do the ends justify the means?
Cell 1984;37(1):7-8.
1984: Elizabeth H Blackburn; P B Challoner
Identification of a telomeric DNA sequence in Trypanosoma brucei.
Cell 1984;36(2):447-57.
1984: Elizabeth H Blackburn
The molecular structure of centromeres and telomeres.
Annual review of biochemistry 1984;53():163-94.
1983: Elizabeth H Blackburn; W C Pan; C C Johnson
Methylation of ribosomal RNA genes in the macronucleus of Tetrahymena thermophila.
Nucleic acids research 1983;11(15):5131-45.
1983: Elizabeth H Blackburn; M L Budarf; P B Challoner; J M Cherry; E A Howard; Alisa L Katzen; W C Pan; T Ryan
DNA termini in ciliate macronuclei.
Cold Spring Harbor symposia on quantitative biology 1983;47 Pt 2():1195-207.
1982: J W Szostak; Elizabeth H Blackburn
Cloning yeast telomeres on linear plasmid vectors.
Cell 1982;29(1):245-55.
1982: W C Pan; E Orias; M Flacks; Elizabeth H Blackburn
Allele-specific, selective amplification of a ribosomal RNA gene in Tetrahymena thermophila.
Cell 1982;28(3):595-604.
1981: Alisa L Katzen; G M Cann; Elizabeth H Blackburn
Sequence-specific fragmentation of macronuclear DNA in a holotrichous ciliate.
Cell 1981;24(2):313-20.
1981: Elizabeth H Blackburn; S S Chiou
Non-nucleosomal packaging of a tandemly repeated DNA sequence at termini of extrachromosomal DNA coding for rRNA in Tetrahymena.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(4):2263-7.
1981: W C Pan; Elizabeth H Blackburn
Single extrachromosomal ribosomal RNA gene copies are synthesized during amplification of the rDNA in Tetrahymena.
Cell 1981;23(2):459-66.
1978: Elizabeth H Blackburn; J G Gall
A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena.
Journal of molecular biology 1978;120(1):33-53.
1976: G M Air; Elizabeth H Blackburn; A R Coulson; F Galibert; Frederick Sanger; J W Sedat; E B Ziff
Gene F of bacteriophage phiX174. Correlation of nucleotide sequences from the DNA and amino acid sequences from the gene product.
Journal of molecular biology 1976;107(4):445-58.
1976: Elizabeth H Blackburn
Transcription and sequence analysis of a fragment of bacteriophage phiX174 DNA.
Journal of molecular biology 1976;107(4):417-31.
1975: G M Air; Elizabeth H Blackburn; Frederick Sanger; A R Coulson
The nucleotide and amino acid sequences of the N (5') terminal region of gene G of bacteriophage phiphiX 174.
Journal of molecular biology 1975;96(4):703-19.
1975: Elizabeth H Blackburn
Transcription by Escherichia coli RNA polymerase of a single-stranded fragment by bacteriophage phiX174 DNA 48 residues in length.
Journal of molecular biology 1975;93(3):367-74.
1972: Elizabeth H Blackburn; F J Hird; I K Jones
Metabolism of glutamine and ammonia in rat liver: the effects of N-acetylglutamate and phosphate.
Archives of biochemistry and biophysics 1972;152(1):265-71.
1972: Elizabeth H Blackburn; F J Hird
Metabolism of glutamine and glutamate by rat liver mitochondria.
Archives of biochemistry and biophysics 1972;152(1):258-64.
1972: B E Davidson; Elizabeth H Blackburn; T A Dopheide
Chorismate mutase-prephenate dehydratase from Escherichia coli K-12. I. Purification, molecular weight, and amino acid composition.
The Journal of biological chemistry 1972;247(14):4441-6.
1967: Elizabeth H Blackburn
Fat absorption studies using triolein I-131 and Oleic Acid I-125 simultaneously.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1967;8(5):356.