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Ninian Blackburn

Research Profile

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Publications

TOP 3
Chelsey D Kline; Mary Mayfield; Ninian J Blackburn
HHM Motif at the CuH-Site of Peptidylglycine Monooxygenase is a pH-Dependent Conformational Switch.
Robert L Osborne; Hui Zhu; Ninian J Blackburn; Anthony T Iavarone; Judith P Klinman
Interdomain long-range electron transfer becomes rate-limiting in the Y216A variant of tyramine β-monooxygenase.
Luciano A Abriata; Ninian J Blackburn; Gabriela N Ledesma; Alejandro J Vila; Damián Álvarez-Paggi; Daniel H Murgida
Alternative ground states enable pathway switching in biological electron transfer.

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All Publications

2013: Chelsey D Kline; Mary Mayfield; Ninian J Blackburn
HHM Motif at the CuH-Site of Peptidylglycine Monooxygenase is a pH-Dependent Conformational Switch.
Biochemistry 2013;52(15):2586-96.
2013: Robert L Osborne; Hui Zhu; Ninian J Blackburn; Anthony T Iavarone; Judith P Klinman
Interdomain long-range electron transfer becomes rate-limiting in the Y216A variant of tyramine β-monooxygenase.
Biochemistry 2013;52(7):1179-91.
2012: Luciano A Abriata; Ninian J Blackburn; Gabriela N Ledesma; Alejandro J Vila; Damián Álvarez-Paggi; Daniel H Murgida
Alternative ground states enable pathway switching in biological electron transfer.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(43):17348-53.
2012: Kelly N Chacón; Ninian J Blackburn
Stable Cu(II) and Cu(I) mononuclear intermediates in the assembly of the CuA center of Thermus thermophilus cytochrome oxidase.
Journal of the American Chemical Society 2012;134(39):16401-12.
2012: Tiffany D Mealman; Vicki H Wysocki; Mowei Zhou; Trisiani Affandi; Mariana E Aranguren; Ninian J Blackburn; Kelly N Chacón; Megan M McEvoy
N-terminal region of CusB is sufficient for metal binding and metal transfer with the metallochaperone CusF.
Biochemistry 2012;51(34):6767-75.
2012: Adenike Otoikhian; Amanda N Barry; Yiping Huang; Svetlana Lutsenko; Mary Mayfield; Mark Nilges; Ninian J Blackburn
Lumenal loop M672-P707 of the Menkes protein (ATP7A) transfers copper to peptidylglycine monooxygenase.
Journal of the American Chemical Society 2012;134(25):10458-68.
2012: Tiffany D Mealman; Ninian J Blackburn; Megan M McEvoy
Metal export by CusCFBA, the periplasmic Cu(I)/Ag(I) transport system of Escherichia coli.
Current topics in membranes 2012;69():163-96.
2011: Amanda N Barry; Sujata Bhatt; Ninian J Blackburn; Adenike Otoikhian; Ujwal Shinde; Ruslan Tsivkovskii; Svetlana Lutsenko
The lumenal loop Met672-Pro707 of copper-transporting ATPase ATP7A binds metals and facilitates copper release from the intramembrane sites.
The Journal of biological chemistry 2011;286(30):26585-94.
2011: Gnana S Siluvai; Michiko Nakano; Mary Mayfield; Ninian J Blackburn
The essential role of the Cu(II) state of Sco in the maturation of the Cu(A) center of cytochrome oxidase: evidence from H135Met and H135SeM variants of the Bacillus subtilis Sco.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2011;16(2):285-97.
2010: Corinna R Hess; Judith P Klinman; Ninian J Blackburn
The copper centers of tyramine β-monooxygenase and its catalytic-site methionine variants: an X-ray absorption study.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2010;15(8):1195-207.
2010: Kevin M Clark; Yang Yu; Nicholas M Marshall; Nathan A Sieracki; Mark Joseph Nilges; Ninian J Blackburn; Wilfred Adrianus van der Donk; Yi Lu
Transforming a blue copper into a red copper protein: engineering cysteine and homocysteine into the axial position of azurin using site-directed mutagenesis and expressed protein ligation.
Journal of the American Chemical Society 2010;132(29):10093-101.
2010: Gnana S Siluvai; Mary Mayfield; Mark Joseph Nilges; Serena DeBeer George; Ninian J Blackburn
Anatomy of a red copper center: spectroscopic identification and reactivity of the copper centers of Bacillus subtilis Sco and its Cys-to-Ala variants.
Journal of the American Chemical Society 2010;132(14):5215-26.
2010: Erik S LeShane; Ujwal Shinde; Joel M Walker; Amanda N Barry; Ninian J Blackburn; Martina Ralle; Svetlana Lutsenko
Interactions between copper-binding sites determine the redox status and conformation of the regulatory N-terminal domain of ATP7B.
The Journal of biological chemistry 2010;285(9):6327-36.
2010: Ninian J Blackburn
A tale of two metals.
Chemistry & biology 2010;17(1):8-9.
2009: Gnana S Siluvai; Michiko M Nakano; Mary Mayfield; Mark Joseph Nilges; Ninian J Blackburn
H135A controls the redox activity of the Sco copper center. Kinetic and spectroscopic studies of the His135Ala variant of Bacillus subtilis Sco.
Biochemistry 2009;48(51):12133-44.
2009: Isabell R Loftin; Ninian J Blackburn; Megan M McEvoy
Tryptophan Cu(I)-pi interaction fine-tunes the metal binding properties of the bacterial metallochaperone CusF.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2009;14(6):905-12.
2009: Christopher J De Feo; Stephen G Aller; Gnana S Siluvai; Ninian J Blackburn; Vinzenz M Unger
Three-dimensional structure of the human copper transporter hCTR1.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(11):4237-42.
2008: Amanda N Barry; Kevin M Clark; Adenike Otoikhian; Wilfred Adrianus van der Donk; Ninian J Blackburn
Selenocysteine positional variants reveal contributions to copper binding from cysteine residues in domains 2 and 3 of human copper chaperone for superoxide dismutase.
Biochemistry 2008;47(49):13074-83.
2008: Ireena Bagai; Christopher Rensing; Ninian J Blackburn; Megan M McEvoy
Direct metal transfer between periplasmic proteins identifies a bacterial copper chaperone.
Biochemistry 2008;47(44):11408-14.
2008: Amanda N Barry; Ninian J Blackburn
A selenocysteine variant of the human copper chaperone for superoxide dismutase. A Se-XAS probe of cluster composition at the domain 3-domain 3 dimer interface.
Biochemistry 2008;47(17):4916-28.
2008: Richard A Himes; Ga Young Park; Gnana Sutha Siluvai; Ninian J Blackburn; Kenneth D Karlin
Structural studies of copper(I) complexes of amyloid-beta peptide fragments: formation of two-coordinate bis(histidine) complexes.
Angewandte Chemie (International ed. in English) 2008;47(47):9084-7.
2007: Ireena Bagai; Wenbo Liu; Christopher Rensing; Ninian J Blackburn; Megan M McEvoy
Substrate-linked conformational change in the periplasmic component of a Cu(I)/Ag(I) efflux system.
The Journal of biological chemistry 2007;282(49):35695-702.
2007: Jay P Stasser; Gnana S Siluvai; Amanda N Barry; Ninian J Blackburn
A multinuclear copper(I) cluster forms the dimerization interface in copper-loaded human copper chaperone for superoxide dismutase.
Biochemistry 2007;46(42):11845-56.
2007: Isabell R Loftin; Sylvia Franke; Ninian J Blackburn; Megan M McEvoy
Unusual Cu(I)/Ag(I) coordination of Escherichia coli CusF as revealed by atomic resolution crystallography and X-ray absorption spectroscopy.
Protein science : a publication of the Protein Society 2007;16(10):2287-93.
2007: Richard A Himes; Ga Young Park; Amanda N Barry; Ninian J Blackburn; Kenneth D Karlin
Synthesis and X-ray absorption spectroscopy structural studies of Cu(I) complexes of histidylhistidine peptides: the predominance of linear 2-coordinate geometry.
Journal of the American Chemical Society 2007;129(17):5352-3.
2007: Andrew T Bauman; Martina Ralle; Ninian J Blackburn
Large scale production of the copper enzyme peptidylglycine monooxygenase using an automated bioreactor.
Protein expression and purification 2007;51(1):34-8.
2006: John P Evans; Ninian J Blackburn; Judith P Klinman
The catalytic role of the copper ligand H172 of peptidylglycine alpha-hydroxylating monooxygenase: a kinetic study of the H172A mutant.
Biochemistry 2006;45(51):15419-29.
2006: Andrew T Bauman; Shulamit Jaron; Erik T Yukl; Joel R Burchfiel; Ninian J Blackburn
pH Dependence of peptidylglycine monooxygenase. Mechanistic implications of Cu-methionine binding dynamics.
Biochemistry 2006;45(37):11140-50.
2006: Mithu De; Joseph Bell; Ninian J Blackburn; Richard E Mains; Betty A Eipper
Role for an essential tyrosine in peptide amidation.
The Journal of biological chemistry 2006;281(30):20873-82.
2006: Andrew T Bauman; Erik T Yukl; Katsiaryna Alkevich; Ashley L McCormack; Ninian J Blackburn
The hydrogen peroxide reactivity of peptidylglycine monooxygenase supports a Cu(II)-superoxo catalytic intermediate.
The Journal of biological chemistry 2006;281(7):4190-8.
2005: Luisa Andruzzi; Michiko M Nakano; Mark Joseph Nilges; Ninian J Blackburn
Spectroscopic studies of metal binding and metal selectivity in Bacillus subtilis BSco, a Homologue of the Yeast Mitochondrial Protein Sco1p.
Journal of the American Chemical Society 2005;127(47):16548-58.
2005: Xavier Siebert; Betty A Eipper; Richard E Mains; Sean T Prigge; Ninian J Blackburn; Mario Amzel
The catalytic copper of peptidylglycine alpha-hydroxylating monooxygenase also plays a critical structural role.
Biophysical journal 2005;89(5):3312-9.
2005: Tiago M Bandeiras; Manuela M Pereira; Miguel Teixeira; Pierre Moenne-Loccoz; Ninian J Blackburn
Structure and coordination of CuB in the Acidianus ambivalens aa3 quinol oxidase heme-copper center.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2005;10(6):625-35.
2005: Jay P Stasser; John F Eisses; Amanda N Barry; Jack H Kaplan; Ninian J Blackburn
Cysteine-to-serine mutants of the human copper chaperone for superoxide dismutase reveal a copper cluster at a domain III dimer interface.
Biochemistry 2005;44(9):3143-52.
2005: Reza A Ghiladi; Hong-Wei Huang; Pierre Moanne-Loccoz; Jay Stasser; Ninian J Blackburn; Amina S Woods; Robert J Cotter; Christopher D Incarvito; Arnold L Rheingold; Kenneth D Karlin
Heme-copper/dioxygen adduct formation relevant to cytochrome c oxidase: spectroscopic characterization of [(6L)FeIII-(O2(2-))-CuII]+.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2005;10(1):63-77.
2004: Martina Ralle; Steven M Berry; Mark Joseph Nilges; Matt D Gieselman; Wilfred Adrianus van der Donk; Yi Lu; Ninian J Blackburn
The selenocysteine-substituted blue copper center: spectroscopic investigations of Cys112SeCys Pseudomonas aeruginosa azurin.
Journal of the American Chemical Society 2004;126(23):7244-56.
2004: Martina Ralle; Svetlana Lutsenko; Ninian J Blackburn
Copper transfer to the N-terminal domain of the Wilson disease protein (ATP7B): X-ray absorption spectroscopy of reconstituted and chaperone-loaded metal binding domains and their interaction with exogenous ligands.
Journal of inorganic biochemistry 2004;98(5):765-74.
2004: Joel M Walker; Daniel Huster; Martina Ralle; Clinton T Morgan; Ninian J Blackburn; Svetlana Lutsenko
The N-terminal metal-binding site 2 of the Wilson's Disease Protein plays a key role in the transfer of copper from Atox1.
The Journal of biological chemistry 2004;279(15):15376-84.
2003: Nicole M Okeley; Moushumi Paul; Jay P Stasser; Ninian J Blackburn; Wilfred Adrianus van der Donk
SpaC and NisC, the cyclases involved in subtilin and nisin biosynthesis, are zinc proteins.
Biochemistry 2003;42(46):13613-24.
2003: Steven M Berry; Martina Ralle; Donald W Low; Ninian J Blackburn; Yi Lu
Probing the role of axial methionine in the blue copper center of azurin with unnatural amino acids.
Journal of the American Chemical Society 2003;125(29):8760-8.
2003: Martina Ralle; Svetlana Lutsenko; Ninian J Blackburn
X-ray absorption spectroscopy of the copper chaperone HAH1 reveals a linear two-coordinate Cu(I) center capable of adduct formation with exogenous thiols and phosphines.
The Journal of biological chemistry 2003;278(25):23163-70.
2003: Wilson A Francisco; Ninian J Blackburn; Judith P Klinman
Oxygen and hydrogen isotope effects in an active site tyrosine to phenylalanine mutant of peptidylglycine alpha-hydroxylating monooxygenase: mechanistic implications.
Biochemistry 2003;42(7):1813-9.
2002: Shulamit Jaron; Richard E Mains; Betty A Eipper; Ninian J Blackburn
The catalytic role of the copper ligand H172 of peptidylglycine alpha-hydroxylating monooxygenase (PHM): a spectroscopic study of the H172A mutant.
Biochemistry 2002;41(44):13274-82.
2002: Wilson A Francisco; Michael J Knapp; Ninian J Blackburn; Judith P Klinman
Hydrogen tunneling in peptidylglycine alpha-hydroxylating monooxygenase.
Journal of the American Chemical Society 2002;124(28):8194-5.
2001: Shulamit Jaron; Ninian J Blackburn
Characterization of a half-apo derivative of peptidylglycine monooxygenase. Insight into the reactivity of each active site copper.
Biochemistry 2001;40(23):6867-75.
2001: F C Rhames; N N Murthy; Kenneth D Karlin; Ninian J Blackburn
Isocyanide binding to the copper(I) centers of the catalytic core of peptidylglycine monooxygenase (PHMcc).
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2001;6(5-6):567-77.
2000: John F Eisses; Jay P Stasser; Martina Ralle; Jack H Kaplan; Ninian J Blackburn
Domains I and III of the human copper chaperone for superoxide dismutase interact via a cysteine-bridged Dicopper(I) cluster.
Biochemistry 2000;39(25):7337-42.
2000: Ninian J Blackburn; F C Rhames; Martina Ralle; Shulamit Jaron
Major changes in copper coordination accompany reduction of peptidylglycine monooxygenase: implications for electron transfer and the catalytic mechanism.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2000;5(3):341-53.
2000: Ninian J Blackburn; Martina Ralle; RF Hassett; Daniel J Kosman
Spectroscopic analysis of the trinuclear cluster in the Fet3 protein from yeast, a multinuclear copper oxidase.
Biochemistry 2000;39(9):2316-24.
1999: Shulamit Jaron; Ninian J Blackburn
Does superoxide channel between the copper centers in peptidylglycine monooxygenase? A new mechanism based on carbon monoxide reactivity.
Biochemistry 1999;38(46):15086-96.
1999: Pamela A Williams; Ninian J Blackburn; Donita Sanders; H Bellamy; Enrico STURA; James A Fee; Duncan E McRee
The CuA domain of Thermus thermophilus ba3-type cytochrome c oxidase at 1.6 A resolution.
Nature structural biology 1999;6(6):509-16.
1999: Martina Ralle; Marina L Verkhovskaya; JE Morgan; Michael I Verkhovsky; Mårten Wikström; Ninian J Blackburn
Coordination of CuB in reduced and CO-liganded states of cytochrome bo3 from Escherichia coli. Is chloride ion a cofactor?
Biochemistry 1999;38(22):7185-94.
1999: Ninian J Blackburn; Martina Ralle; E Gomez; Michael G Hill; Andrzej Pastuszyn; Donita Sanders; James A Fee
Selenomethionine-substituted Thermus thermophilus cytochrome ba3: characterization of the CuA site by Se and Cu K-EXAFS.
Biochemistry 1999;38(22):7075-84.
1998: Wilson A Francisco; David J Merkler; Ninian J Blackburn; Judith P Klinman
Kinetic mechanism and intrinsic isotope effects for the peptidylglycine alpha-amidating enzyme reaction.
Biochemistry 1998;37(22):8244-52.
1998: F H Périé; Vijay Reddy; Ninian J Blackburn; Michael H Gold
Purification and characterization of laccases from the white-rot basidiomycete Dichomitus squalens.
Archives of biochemistry and biophysics 1998;353(2):349-55.
1997: J Bell; D E Ash; L M Snyder; R Kulathila; Ninian J Blackburn; David J Merkler
Structural and functional investigations on the role of zinc in bifunctional rat peptidylglycine alpha-amidating enzyme.
Biochemistry 1997;36(51):16239-46.
1996: J S Boswell; B J Reedy; R Kulathila; David J Merkler; Ninian J Blackburn
Structural investigations on the coordination environment of the active-site copper centers of recombinant bifunctional peptidylglycine alpha-amidating enzyme.
Biochemistry 1996;35(38):12241-50.
1995: Y C Fann; I Ahmed; Ninian J Blackburn; J S Boswell; Marina L Verkhovskaya; Brian M Hoffman; Mårten Wikström
Structure of CuB in the binuclear heme-copper center of the cytochrome aa3-type quinol oxidase from Bacillus subtilis: an ENDOR and EXAFS study.
Biochemistry 1995;34(32):10245-55.
1995: Betty A Eipper; A S Quon; Richard E Mains; J S Boswell; Ninian J Blackburn
The catalytic core of peptidylglycine alpha-hydroxylating monooxygenase: investigation by site-directed mutagenesis, Cu X-ray absorption spectroscopy, and electron paramagnetic resonance.
Biochemistry 1995;34(9):2857-65.
1994: Ninian J Blackburn; M E Barr; W H Woodruff; J van der Oost; S de Vries
Metal-metal bonding in biology: EXAFS evidence for a 2.5 A copper-copper bond in the CuA center of cytochrome oxidase.
Biochemistry 1994;33(34):10401-7.
1992: Ninian J Blackburn; Richard W Strange; R T Carr; S J Benkovic
X-ray absorption studies of the Cu-dependent phenylalanine hydroxylase from Chromobacterium violaceum. Comparison of the copper coordination in oxidized and dithionite-reduced enzymes.
Biochemistry 1992;31(23):5298-303.
1991: Ninian J Blackburn; S Samar Hasnain; T M Pettingill; Richard W Strange
Copper K-extended x-ray absorption fine structure studies of oxidized and reduced dopamine beta-hydroxylase. Confirmation of a sulfur ligand to copper(I) in the reduced enzyme.
The Journal of biological chemistry 1991;266(34):23120-7.
1991: T M Pettingill; Richard W Strange; Ninian J Blackburn
Carbonmonoxy dopamine beta-hydroxylase. Structural characterization by Fourier transform infrared, fluorescence, and x-ray absorption spectroscopy.
The Journal of biological chemistry 1991;266(26):16996-7003.
1990: Ninian J Blackburn; T M Pettingill; K S Seagraves; R T Shigeta
Characterization of a carbon monoxide complex of reduced dopamine beta-hydroxylase. Evidence for inequivalence of the Cu(I) centers.
The Journal of biological chemistry 1990;265(26):15383-6.
1988: Ninian J Blackburn; M Concannon; S K Shahiyan; F E Mabbs; D Collison
Active site of dopamine beta-hydroxylase. Comparison of enzyme derivatives containing four and eight copper atoms per tetramer using potentiometry and EPR spectroscopy.
Biochemistry 1988;27(16):6001-8.
1988: Y Mino; H Wariishi; Ninian J Blackburn; Thomas M Loehr; Michael H Gold
Spectral characterization of manganese peroxidase, an extracellular heme enzyme from the lignin-degrading basidiomycete, Phanerochaete chrysosporium.
The Journal of biological chemistry 1988;263(15):7029-36.
1984: S Samar Hasnain; G P Diakun; P F Knowles; N Binsted; C David Garner; Ninian J Blackburn
Direct structural information for the copper site of dopamine beta-mono-oxygenase obtained by using extended X-ray-absorption fine structure.
The Biochemical journal 1984;221(2):545-8.
1984: Ninian J Blackburn; D Collison; J Sutton; F E Mabbs
Kinetic and e.p.r. studies of cyanide and azide binding to the copper sites of dopamine (3,4-dihydroxyphenethylamine) beta-mono-oxygenase.
The Biochemical journal 1984;220(2):447-54.
1984: Ninian J Blackburn; S Samar Hasnain; N Binsted; G P Diakun; C David Garner; P F Knowles
An extended-X-ray-absorption-fine-structure study of bovine erythrocyte superoxide dismutase in aqueous solution. Direct evidence for three-co-ordinate Cu(I) in reduced enzyme.
The Biochemical journal 1984;219(3):985-90.
1983: Ninian J Blackburn; S Samar Hasnain; G P Diakun; P F Knowles; N Binsted; C David Garner
An extended X-ray-absorption-fine-structure study of the copper and zinc sites of freeze-dried bovine superoxide dismutase.
The Biochemical journal 1983;213(3):765-8.
1980: Ninian J Blackburn; H S Mason; P F Knowles
Dopamine-beta-hydroxylase: evidence for binuclear copper sites.
Biochemical and biophysical research communications 1980;95(3):1275-81.
1976: P McMahill; Ninian J Blackburn; H S Mason
An interesting reaction of cupric ions with ferricyanide and ferrocyanide.
Advances in experimental medicine and biology 1976;74():470-1.