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Ralph Theo Schermuly

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Djuro Kosanovic; Irwin Reiss; Ralph Theo Schermuly; Werner Seeger; Norbert Weissmann; Malgorzata Wygrecka; Bhola Kumar Dahal; Hossein Ardeschir Ghofrani; Friedrich Grimminger; Andreas Günther; Gamal-Andre Banat
Mast cell Chymase: an indispensable instrument in the pathological symphony of idiopathic pulmonary fibrosis?
Tatyana Novoyatleva; Chinmoy Patra; Guido Posern; Ralph Theo Schermuly; Yves Schymura; Frederic Strobl; Jakub M Swiercz; Astrid Wietelmann; Timothy S Zheng; Wiebke Janssen; Felix B Engel
Deletion of Fn14 receptor protects from right heart fibrosis and dysfunction.
Soni Pullamsetti; Gamal-Andre Banat; T Braun; Friedrich Grimminger; Jörg Hänze; E Kolosionek; D Pomagruk; Ralph Theo Schermuly; A Schmall; Werner Seeger; M Szibor; Jochen Wilhelm; Rajkumar Savai
Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF.

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All Publications

2013: Djuro Kosanovic; Irwin Reiss; Ralph Theo Schermuly; Werner Seeger; Norbert Weissmann; Malgorzata Wygrecka; Bhola Kumar Dahal; Hossein Ardeschir Ghofrani; Friedrich Grimminger; Andreas Günther; Gamal-Andre Banat
Mast cell Chymase: an indispensable instrument in the pathological symphony of idiopathic pulmonary fibrosis?
Histology and histopathology 2013;28(6):691-9.
2013: Tatyana Novoyatleva; Chinmoy Patra; Guido Posern; Ralph Theo Schermuly; Yves Schymura; Frederic Strobl; Jakub M Swiercz; Astrid Wietelmann; Timothy S Zheng; Wiebke Janssen; Felix B Engel
Deletion of Fn14 receptor protects from right heart fibrosis and dysfunction.
Basic research in cardiology 2013;108(2):325.
2013: Soni Pullamsetti; Gamal-Andre Banat; T Braun; Friedrich Grimminger; Jörg Hänze; E Kolosionek; D Pomagruk; Ralph Theo Schermuly; A Schmall; Werner Seeger; M Szibor; Jochen Wilhelm; Rajkumar Savai
Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF.
Oncogene 2013;32(9):1121-34.
2013: Katja Hattar; Dagmar S Lang; Rajkumar Savai; Ralph Theo Schermuly; Anja Schmall; Werner Seeger; Ulf Sibelius; Florentine S B Subtil; Ekkehard Vollmer; Jochen Wilhelm; Gamal-Andre Banat; Gabriele Dahlem; Bastian Eul; Ludger Fink; Torsten Goldmann; Friedrich Grimminger; Ulrich Grandel
Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation.
Cancer immunology, immunotherapy : CII 2013;62(2):309-20.
2013: Christine Veith; Florian Veit; Norbert Weissmann; Jochen Wilhelm; Bhola Kumar Dahal; Ludger Fink; Hossein A Ghofrani; Friedrich Grimminger; Walter Klepetko; Gabriel Marta; Ralph Theo Schermuly; Sigrid Schmitt; Werner Seeger; Grazyna Kwapiszewska
Cofilin, a hypoxia-regulated protein in murine lungs identified by 2DE: role of the cytoskeletal protein cofilin in pulmonary hypertension.
Proteomics 2013;13(1):75-88.
2013: Jun Yang; Ralph Theo Schermuly; Astrid Weiss; Changxin Wu; Rafia S Al-Lamki; Joachim Berk; Xiaohui Li; Nicholas W Morrell
Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(1):34-42.
2013: Wiebke Janssen; Soni Pullamsetti; John Cooke; Andreas Guenther; Norbert Weissmann; Ralph Theo Schermuly
The role of dimethylarginine dimethylaminohydrolase (DDAH) in pulmonary fibrosis.
The Journal of pathology 2013;229(2):242-9.
2012: Rajkumar Savai; Axel Scheed; Werner Seeger; Axel Vater; Robert Voswinckel; Norbert Weissmann; Gamal-Andre Banat; Ewa Bieniek; Bhola K Dahal; Ludger Fink; Hossein A Ghofrani; Friedrich Grimminger; Walter Klepetko; Sven Klussmann; Julia Kolbe; Soni Pullamsetti; Christin Ritter; Ralph Theo Schermuly
Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension.
American journal of respiratory and critical care medicine 2012;186(9):897-908.
2012: Soni Pullamsetti; Stephan Rosenkranz; Rajkumar Savai; Werner Seeger; Aleksandra Tretyn; Norbert Weissmann; Eva Maria Berghausen; Ralf P Brandes; Elsa Butrous; Ghazwan Butrous; Swati Dabral; Bhola Kumar Dahal; Hossein A Ghofrani; Friedrich Grimminger; Ralph Theo Schermuly
Role of Src tyrosine kinases in experimental pulmonary hypertension.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(6):1354-65.
2012: Grazyna Kwapiszewska; Philipp Markart; Leigh Matthew Marsh; Andreas Meinhardt; Andrea Olschewski; Klaus Theo Preissner; Ralph Theo Schermuly; Werner Seeger; Martin Steinhoff; Christian Taube; Norbert Weissmann; Bhola Kumar Dahal; Hossein A Ghofrani; Baktybek Kojonazarov; Malgorzata Wygrecka
PAR-2 inhibition reverses experimental pulmonary hypertension.
Circulation research 2012;110(9):1179-91.
2012: Manish Mittal; Oleg Pak; Matthew E Pamenter; Ralph Theo Schermuly; Werner Seeger; Ralf P Brandes; D Beate Fuchs; H A Ghofrani; Friedrich Grimminger; Xiang Q Gu; Daniela Haag; Gabriel G Haddad; Norbert Weissmann
Hypoxia induces Kv channel current inhibition by increased NADPH oxidase-derived reactive oxygen species.
Free radical biology & medicine 2012;52(6):1033-42.
2012: Soni Pullamsetti; Rajkumar Savai; Werner Seeger; Norbert Weissmann; Andreas M Zeiher; Angelika Bonauer; Bhola K Dahal; Stefanie Dimmeler; Carmen Doebele; Ariane Fischer; Hossein A Ghofrani; Friedrich Grimminger; Baktybek Kojonazarov; Ralph Theo Schermuly
Inhibition of microRNA-17 improves lung and heart function in experimental pulmonary hypertension.
American journal of respiratory and critical care medicine 2012;185(4):409-19.
2012: Michaela Lang; Hossein Ardeschir Ghofrani; Friedrich Grimminger; Anuar Kalymbetov; Baktybek Kojonazarov; Axel Kretschmer; Werner Seeger; Johannes-Peter Stasch; Xia Tian; Norbert Weissmann; Ralph Theo Schermuly
The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats.
PloS one 2012;7(8):e43433.
2012: Norbert Weissmann; Michael Mederos y Schnitzler; Ralf P Brandes; Alison C Brewer; Marc Freichel; Beate Fuchs; Hossein A Ghofrani; Friedrich Grimminger; Thomas Gudermann; Hermann Kalwa; Karl-Heinz Krause; Marcel Meissner; Stefan Offermanns; Oleg Pak; Ralph Theo Schermuly; Harald H H W Schmidt; Werner Seeger; Ajay M Shah; Ursula Storch; Akylbek Sydykov; Florian Veit; Alexander Dietrich
Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice.
Nature communications 2012;3():649.
2011: Soni Pullamsetti; Rajkumar Savai; Werner Seeger; Norbert Weissmann; Jochen Wilhelm; Dariusz Zakrzewicz; Bhola Kumar Dahal; Rio Dumitrascu; Oliver Eickelberg; Hossein A Ghofrani; Friedrich Grimminger; Andreas Guenther; Melanie Konigshoff; James Leiper; Ralph Theo Schermuly
The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis.
Science translational medicine 2011;3(87):87ra53.
2011: R Dumitrascu; C Kulcke; M Königshoff; F Kouri; X Yang; N Morrell; Hossein A Ghofrani; Norbert Weissmann; R Reiter; Werner Seeger; Friedrich Grimminger; O Eickelberg; Ralph Theo Schermuly; S S Pullamsetti
Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats.
The European respiratory journal 2011;37(5):1104-18.
2011: Bhola K Dahal; Hossein A Ghofrani; Friedrich Grimminger; Rainer Heuchel; Soni Pullamsetti; Werner Seeger; Norbert Weissmann; Jochen Wilhelm; Ralph Theo Schermuly
Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-β.
Pulmonary circulation 2011;1(2):259-68.
2011: Soni Savai Pullamsetti; Rajkumar Savai; Martina Barbara Schaefer; Jochen Wilhelm; Hossein A Ghofrani; Norbert Weissmann; Christian Schudt; Ingrid Fleming; Konstantin Mayer; James Leiper; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases.
Circulation 2011;123(11):1194-204.
2011: Nikolaus Kneidinger; Ali Önder Yildirim; Jens Callegari; Shinji Takenaka; Maria Magdalena Stein; Rio Dumitrascu; Alexander Bohla; Ken R Bracke; Rory E Morty; Guy G Brusselle; Ralph Theo Schermuly; Oliver Eickelberg; Melanie Königshoff
Activation of the WNT/β-catenin pathway attenuates experimental emphysema.
American journal of respiratory and critical care medicine 2011;183(6):723-33.
2011: Jes-Niels Boeckel; Virginia Guarani; Masamichi Koyanagi; Tino Roexe; Andreas Lengeling; Ralph Theo Schermuly; Pascal Gellert; Thomas Braun; Andreas Zeiher; Stefanie Dimmeler
Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(8):3276-81.
2011: Djuro Kosanovic; Himal Luitel; Werner Seeger; Akylbek Sydykov; Norbert Weissmann; Ralf P Brandes; Teodora Cornitescu; Bhola K Dahal; Neil Davie; Hossein A Ghofrani; Friedrich Grimminger; Wiebke Janssen; Baktybek Kojonazarov; Ralph Theo Schermuly
Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension.
Respiratory research 2011;12():87.
2011: Bhola K Dahal; Djuro Kosanovic; Christina Kaulen; Teodora Cornitescu; Rajkumar Savai; Julia Hoffmann; Irwin Reiss; Hossein A Ghofrani; Norbert Weissmann; Wolfgang M Kuebler; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats.
Respiratory research 2011;12():60.
2011: Piotr Sklepkiewicz; Ralph Theo Schermuly; Xia Tian; Hossein Ardeschir Ghofrani; Norbert Weissmann; Daniel Sedding; Tarek Kashour; Werner Seeger; Friedrich Grimminger; Soni Savai Pullamsetti
Glycogen synthase kinase 3beta contributes to proliferation of arterial smooth muscle cells in pulmonary hypertension.
PloS one 2011;6(4):e18883.
2011: Xia Tian; Christina Vroom; Hossein Ardeschir Ghofrani; Norbert Weissmann; Ewa Bieniek; Friedrich Grimminger; Werner Seeger; Ralph Theo Schermuly; Soni Savai Pullamsetti
Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling.
PloS one 2011;6(4):e18136.
2011: Beate Fuchs; Markus Rupp; Hossein A Ghofrani; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger; Thomas Gudermann; Alexander Dietrich; Norbert Weissmann
Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6.
Respiratory research 2011;12():20.
2011: S S Pullamsetti; Rajkumar Savai; W Janssen; B K Dahal; Werner Seeger; Friedrich Grimminger; Hossein A Ghofrani; Norbert Weissmann; Ralph Theo Schermuly
Inflammation, immunological reaction and role of infection in pulmonary hypertension.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2011;17(1):7-14.
2010: Beate Fuchs; Natascha Sommer; Alexander Dietrich; Ralph Theo Schermuly; Hossein Ardeschir Ghofrani; Friedrich Grimminger; Werner Seeger; Thomas Gudermann; Norbert Weissmann
Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstriction.
Respiratory physiology & neurobiology 2010;174(3):282-91.
2010: V S Nikam; Ralph Theo Schermuly; R Dumitrascu; Norbert Weissmann; G Kwapiszewska; N Morrell; W Klepetko; L Fink; Werner Seeger; Robert Voswinckel
Treprostinil inhibits the recruitment of bone marrow-derived circulating fibrocytes in chronic hypoxic pulmonary hypertension.
The European respiratory journal 2010;36(6):1302-14.
2010: Melanie Königshoff; Rio Dumitrascu; Sergey Udalov; Oana Veronica Amarie; Rudolf Reiter; Friedrich Grimminger; Werner Seeger; Ralph Theo Schermuly; Oliver Eickelberg
Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention.
Thorax 2010;65(11):949-55.
2010: N Sommer; O Pak; S Schörner; T Derfuss; A Krug; E Gnaiger; Hossein A Ghofrani; Ralph Theo Schermuly; C Huckstorf; Werner Seeger; Friedrich Grimminger; Norbert Weissmann
Mitochondrial cytochrome redox states and respiration in acute pulmonary oxygen sensing.
The European respiratory journal 2010;36(5):1056-66.
2010: B K Dahal; D Kosanovic; P K Pamarthi; A Sydykov; Y-J Lai; R Kast; H Schirok; J-P Stasch; Hossein A Ghofrani; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Ralph Theo Schermuly
Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension.
The European respiratory journal 2010;36(4):808-18.
2010: Matthias Hecker; Zbigniew Zaslona; Grazyna Kwapiszewska; Gero Niess; Anna Zakrzewicz; Eduard Hergenreider; Jochen Wilhelm; Leigh M Marsh; Daniel G Sedding; Walter Klepetko; Jürgen Lohmeyer; Stefanie Dimmeler; Werner Seeger; Norbert Weissmann; Ralph Theo Schermuly; Nikolaus Kneidinger; Oliver Eickelberg; Rory Morty
Dysregulation of the IL-13 receptor system: a novel pathomechanism in pulmonary arterial hypertension.
American journal of respiratory and critical care medicine 2010;182(6):805-18.
2010: Katja Hattar; S Oppermann; C Ankele; Norbert Weissmann; Ralph Theo Schermuly; Rainer M Bohle; R Moritz; B Krögel; Werner Seeger; Friedrich Grimminger; Ulf Sibelius; Ulrich Grandel
c-ANCA-induced neutrophil-mediated lung injury: a model of acute Wegener's granulomatosis.
The European respiratory journal 2010;36(1):187-95.
2010: Ingrid Henneke; Susanne Greschus; Rajkumar Savai; Martina Korfei; Philipp Markart; Poornima Mahavadi; Ralph Theo Schermuly; Malgorzata Wygrecka; Jörg Stürzebecher; Werner Seeger; Andreas Günther; Clemens Ruppert
Inhibition of urokinase activity reduces primary tumor growth and metastasis formation in a murine lung carcinoma model.
American journal of respiratory and critical care medicine 2010;181(6):611-9.
2010: Alexi Crosby; Frances M Jones; Mark Southwood; Susan Stewart; Ralph Theo Schermuly; Ghazwan Butrous; David W Dunne; Nicholas W Morrell
Pulmonary vascular remodeling correlates with lung eggs and cytokines in murine schistosomiasis.
American journal of respiratory and critical care medicine 2010;181(3):279-88.
2010: Bhola Kumar Dahal; Teodora Cornitescu; Aleksandra Tretyn; Soni Savai Pullamsetti; Djuro Kosanovic; Rio Dumitrascu; Hossein A Ghofrani; Norbert Weissmann; Robert Voswinckel; Gamal-Andre Banat; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Role of epidermal growth factor inhibition in experimental pulmonary hypertension.
American journal of respiratory and critical care medicine 2010;181(2):158-67.
2010: Sevdalina Nikolova; Andreas Guenther; Rajkumar Savai; Norbert Weissmann; Hossein A Ghofrani; Melanie Konigshoff; Oliver Eickelberg; Walter Klepetko; Robert Voswinckel; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly; Soni Pullamsetti
Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis.
Respiratory research 2010;11():146.
2010: Bakytbek Egemnazarov; Ralph Theo Schermuly; Bhola K Dahal; Garry T Elliott; Niel C Hoglen; Mark W Surber; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Hossein A Ghofrani
Nebulization of the acidified sodium nitrite formulation attenuates acute hypoxic pulmonary vasoconstriction.
Respiratory research 2010;11():81.
2010: Sergey Udalov; Rio Dumitrascu; Soni Pullamsetti; Hamza M Al-tamari; Norbert Weissmann; Hossein A Ghofrani; Andreas Guenther; Robert Voswinckel; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice.
BMC pulmonary medicine 2010;10():26.
2010: Friedrich Grimminger; Ralph Theo Schermuly
PDGF receptor and its antagonists: role in treatment of PAH.
Advances in experimental medicine and biology 2010;661():435-46.
2010: Rajkumar Savai; Soni Savai Pullamsetti; Gamal-Andre Banat; Norbert Weissmann; Hossein Ardeschir Ghofrani; Friedrich Grimminger; Ralph Theo Schermuly
Targeting cancer with phosphodiesterase inhibitors.
Expert opinion on investigational drugs 2010;19(1):117-31.
2009: Arun Kumarasamy; Isabelle Schmitt; Alexander H Nave; Irwin Reiss; Irene van der Horst; Eva Dony; Jesse D Roberts; Ronald R de Krijger; Dick Tibboel; Werner Seeger; Ralph Theo Schermuly; Oliver Eickelberg; Rory Morty
Lysyl oxidase activity is dysregulated during impaired alveolarization of mouse and human lungs.
American journal of respiratory and critical care medicine 2009;180(12):1239-52.
2009: Ewa Kolosionek; Rajkumar Savai; Hossein A Ghofrani; Norbert Weissmann; Andreas Guenther; Friedrich Grimminger; Werner Seeger; Gamal-Andre Banat; Ralph Theo Schermuly; Soni Pullamsetti
Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4.
Molecular biology of the cell 2009;20(22):4751-65.
2009: Norbert Weissmann; Sascha Hackemack; Bhola Kumar Dahal; Soni Savai Pullamsetti; Rajkumar Savai; Manish Mittal; Beate Fuchs; Thomas Medebach; Rio Dumitrascu; Martin van Eickels; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
The soluble guanylate cyclase activator HMR1766 reverses hypoxia-induced experimental pulmonary hypertension in mice.
American journal of physiology. Lung cellular and molecular physiology 2009;297(4):L658-65.
2009: Markus Roth; Markus Rupp; Simone Hofmann; Manish Mittal; Beate Fuchs; Natascha Sommer; Nirmal Parajuli; Karin Quanz; Dominic Schubert; Eva Dony; Ralph Theo Schermuly; Hossein A Ghofrani; Ulrike Sausbier; Katrin Rutschmann; Sarah Wilhelm; Werner Seeger; Peter Ruth; Friedrich Grimminger; Matthias Sausbier; Norbert Weissmann
Heme oxygenase-2 and large-conductance Ca2+-activated K+ channels: lung vascular effects of hypoxia.
American journal of respiratory and critical care medicine 2009;180(4):353-64.
2009: Isabel P Laumanns; Ludger Fink; Jochen Wilhelm; Jens-C Wolff; Rita Mitnacht-Kraus; Sabine Graef-Hoechst; Maria M Stein; Rainer M Bohle; Walter Klepetko; Mir A R Hoda; Ralph Theo Schermuly; Friedrich Grimminger; Werner Seeger; Robert Voswinckel
The noncanonical WNT pathway is operative in idiopathic pulmonary arterial hypertension.
American journal of respiratory cell and molecular biology 2009;40(6):683-91.
2009: Friedrich Grimminger; G Weimann; Reiner Frey; Robert Voswinckel; M Thamm; D Bölkow; Norbert Weissmann; W Mück; S Unger; G Wensing; Ralph Theo Schermuly; Hossein A Ghofrani
First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension.
The European respiratory journal 2009;33(4):785-92.
2009: K Woyda; S Koebrich; Irwin Reiss; Silvia Rudloff; Soni Pullamsetti; A Rühlmann; Norbert Weissmann; Hossein A Ghofrani; Andreas Günther; Werner Seeger; Friedrich Grimminger; Rory Morty; Ralph Theo Schermuly
Inhibition of phosphodiesterase 4 enhances lung alveolarisation in neonatal mice exposed to hyperoxia.
The European respiratory journal 2009;33(4):861-70.
2009: Bakytbek Egemnazarov; Akylbek Sydykov; Ralph Theo Schermuly; Norbert Weissmann; Johannes-Peter Stasch; Akpai S Sarybaev; Werner Seeger; Friedrich Grimminger; Hossein A Ghofrani
Novel soluble guanylyl cyclase stimulator BAY 41-2272 attenuates ischemia-reperfusion-induced lung injury.
American journal of physiology. Lung cellular and molecular physiology 2009;296(3):L462-9.
2009: Robert Voswinckel; Frank Reichenberger; Henning Gall; Thomas Schmehl; Tobias Gessler; Ralph Theo Schermuly; Friedrich Grimminger; Lewis J Rubin; Werner Seeger; Hossein A Ghofrani; Horst Olschewski
Metered dose inhaler delivery of treprostinil for the treatment of pulmonary hypertension.
Pulmonary pharmacology & therapeutics 2009;22(1):50-6.
2008: N Sommer; Alexander Dietrich; Ralph Theo Schermuly; Hossein A Ghofrani; Thomas Gudermann; Rainer Schulz; Werner Seeger; Friedrich Grimminger; Norbert Weissmann
Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms.
The European respiratory journal 2008;32(6):1639-51.
2008: Martina Klein; Ralph Theo Schermuly; Peter Ellinghaus; Hendrik Milting; Bernd Riedl; Sevdalina Nikolova; Soni S Pullamsetti; Norbert Weissmann; Eva Dony; Rajkumar Savai; Hossein A Ghofrani; Friedrich Grimminger; Andreas E Busch; Stefan Schäfer
Combined tyrosine and serine/threonine kinase inhibition by sorafenib prevents progression of experimental pulmonary hypertension and myocardial remodeling.
Circulation 2008;118(20):2081-90.
2008: Robert Voswinckel; Frank Reichenberger; Beate Enke; Andre Kreckel; Stefanie Krick; Henning Gall; Ralph Theo Schermuly; Friedrich Grimminger; Lewis J Rubin; Horst Olschewski; Werner Seeger; Hossein A Ghofrani
Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension.
Pulmonary pharmacology & therapeutics 2008;21(5):824-32.
2008: J Sevilla-Pérez; Melanie Königshoff; Grazyna Kwapiszewska; Oana V Amarie; Werner Seeger; Norbert Weissmann; Ralph Theo Schermuly; Rory Morty; Oliver Eickelberg
Shroom expression is attenuated in pulmonary arterial hypertension.
The European respiratory journal 2008;32(4):871-80.
2008: Ralph Theo Schermuly; J-P Stasch; Soni Pullamsetti; Ralf Middendorff; D Müller; Klaus-Dieter Schlüter; A Dingendorf; S Hackemack; E Kolosionek; C Kaulen; Rio Dumitrascu; Norbert Weissmann; J Mittendorf; Walter Klepetko; Werner Seeger; Hossein A Ghofrani; Friedrich Grimminger
Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension.
The European respiratory journal 2008;32(4):881-91.
2008: Grazyna Kwapiszewska; Malgorzata Wygrecka; Leigh M Marsh; Sigrid Schmitt; Roger Trösser; Jochen Wilhelm; Katja Helmus; Bastian Eul; Anna Zakrzewicz; Hossein A Ghofrani; Ralph Theo Schermuly; Rainer M Bohle; Friedrich Grimminger; Werner Seeger; Oliver Eickelberg; Ludger Fink; Norbert Weissmann
Fhl-1, a new key protein in pulmonary hypertension.
Circulation 2008;118(11):1183-94.
2008: Ying-Ju Lai; Soni Pullamsetti; Eva Dony; Norbert Weissmann; Ghazwan Butrous; Gamal-Andre Banat; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension.
American journal of respiratory and critical care medicine 2008;178(2):188-96.
2008: István Vadász; Ralph Theo Schermuly; Hossein A Ghofrani; Sebastian Rummel; Susan Wehner; Inge Mühldorfer; Klaus P Schäfer; Werner Seeger; Rory Morty; Friedrich Grimminger; Norbert Weissmann
The lectin-like domain of tumor necrosis factor-alpha improves alveolar fluid balance in injured isolated rabbit lungs.
Critical care medicine 2008;36(5):1543-50.
2008: Eva Dony; Y-J Lai; Rio Dumitrascu; Soni Pullamsetti; Rajkumar Savai; Hossein A Ghofrani; Norbert Weissmann; Christian Schudt; D Flockerzi; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Partial reversal of experimental pulmonary hypertension by phosphodiesterase-3/4 inhibition.
The European respiratory journal 2008;31(3):599-610.
2008: Rio Dumitrascu; Silke Koebrich; Eva Dony; Norbert Weissmann; Rajkumar Savai; Soni Pullamsetti; Hossein A Ghofrani; Arun Samidurai; Heiko Traupe; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Characterization of a murine model of monocrotaline pyrrole-induced acute lung injury.
BMC pulmonary medicine 2008;8():25.
2007: Frank Reichenberger; Robert Voswinckel; Beate Enke; M Rutsch; E El Fechtali; Thomas Schmehl; Horst Olschewski; Ralph Theo Schermuly; Norbert Weissmann; Hossein A Ghofrani; Friedrich Grimminger; E Mayer; Werner Seeger
Long-term treatment with sildenafil in chronic thromboembolic pulmonary hypertension.
The European respiratory journal 2007;30(5):922-7.
2007: Norbert Weissmann; Boris Gerigk; Ozlem Kocer; Matthias Nollen; Sascha Hackemack; Hossein A Ghofrani; Ralph Theo Schermuly; Ghazwan Butrous; Andreas Schulz; Markus Roth; Werner Seeger; Friedrich Grimminger
Hypoxia-induced pulmonary hypertension: different impact of iloprost, sildenafil, and nitric oxide.
Respiratory medicine 2007;101(10):2125-32.
2007: Hemal H Patel; Shen Zhang; Fiona Murray; Ryan Y S Suda; Brian P Head; Utako Yokoyama; James S Swaney; Ingrid R Niesman; Ralph Theo Schermuly; Soni Pullamsetti; Patricia A Thistlethwaite; Atsushi Miyanohara; Marilyn G Farquhar; Jason X-J Yuan; Paul Insel
Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(11):2970-9.
2007: Manish Mittal; Markus Roth; Peter König; Simone Hofmann; Eva Dony; Parag Goyal; Anne-Christin Selbitz; Ralph Theo Schermuly; Hossein A Ghofrani; Grazyna Kwapiszewska; Wolfgang Kummer; Walter Klepetko; Mir Ali Reza Hoda; Ludger Fink; Jörg Hänze; Werner Seeger; Friedrich Grimminger; Harald Schmidt; Norbert Weissmann
Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature.
Circulation research 2007;101(3):258-67.
2007: Anna Zakrzewicz; Matthias Hecker; Leigh M Marsh; Grazyna Kwapiszewska; Bozena Nejman; Lu Long; Werner Seeger; Ralph Theo Schermuly; Nicholas W Morrell; Rory Morty; Oliver Eickelberg
Receptor for activated C-kinase 1, a novel interaction partner of type II bone morphogenetic protein receptor, regulates smooth muscle cell proliferation in pulmonary arterial hypertension.
Circulation 2007;115(23):2957-68.
2007: Rajkumar Savai; Ralph Theo Schermuly; Soni Pullamsetti; Michael Schneider; Susanne Greschus; Hossein A Ghofrani; Heiko Traupe; Friedrich Grimminger; Gamal-Andre Banat
A combination hybrid-based vaccination/adoptive cellular therapy to prevent tumor growth by involvement of T cells.
Cancer research 2007;67(11):5443-53.
2007: Anna Zakrzewicz; Fotini M Kouri; Bozena Nejman; Grazyna Kwapiszewska; Matthias Hecker; R Sandu; Eva Dony; Werner Seeger; Ralph Theo Schermuly; Oliver Eickelberg; Rory Morty
The transforming growth factor-beta/Smad2,3 signalling axis is impaired in experimental pulmonary hypertension.
The European respiratory journal 2007;29(6):1094-104.
2007: Ralph Theo Schermuly; Soni Pullamsetti; Grazyna Kwapiszewska; Rio Dumitrascu; Xia Tian; Norbert Weissmann; Hossein A Ghofrani; Christina Kaulen; Torsten R Dunkern; Christian Schudt; Robert Voswinckel; Jiang Zhou; Arun Samidurai; Walter Klepetko; Renate Paddenberg; Wolfgang Kummer; Werner Seeger; Friedrich Grimminger
Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy.
Circulation 2007;115(17):2331-9.
2007: Rory Morty; Bozena Nejman; Grazyna Kwapiszewska; Matthias Hecker; Anna Zakrzewicz; Fotini M Kouri; Dorothea M Peters; Rio Dumitrascu; Werner Seeger; Petra Knaus; Ralph Theo Schermuly; Oliver Eickelberg
Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(5):1072-8.
2007: Miguel A Alejandre-Alcázar; Grazyna Kwapiszewska; Irwin Reiss; Oana V Amarie; Leigh M Marsh; Julia Sevilla-Pérez; Malgorzata Wygrecka; Bastian Eul; Silke Köbrich; Mareike Hesse; Ralph Theo Schermuly; Werner Seeger; Oliver Eickelberg; Rory Morty
Hyperoxia modulates TGF-beta/BMP signaling in a mouse model of bronchopulmonary dysplasia.
American journal of physiology. Lung cellular and molecular physiology 2007;292(2):L537-49.
2007: Ralph Theo Schermuly; Soni Pullamsetti; Susanne C Breitenbach; Norbert Weissmann; Hossein A Ghofrani; Friedrich Grimminger; Sigrid M Nilius; Karsten Schrör; Jutta M Kirchrath; Werner Seeger; Frank Rose
Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs.
Respiratory research 2007;8():4.
2007: Bernhard Rosengarten; Mirko Hecht; Dieter Auch; Hossein A Ghofrani; Ralph Theo Schermuly; Friedrich Grimminger; Manfred Kaps
Microcirculatory dysfunction in the brain precedes changes in evoked potentials in endotoxin-induced sepsis syndrome in rats.
Cerebrovascular diseases (Basel, Switzerland) 2007;23(2-3):140-7.
2006: Norbert Weissmann; Alexander Dietrich; Beate Fuchs; Hermann Kalwa; Mahmut Ay; Rio Dumitrascu; Andrea Olschewski; Ursula Storch; Michael Mederos y Schnitzler; Hossein A Ghofrani; Ralph Theo Schermuly; Olaf Pinkenburg; Werner Seeger; Friedrich Grimminger; Thomas Gudermann
Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(50):19093-8.
2006: Robert Voswinckel; Beate Enke; Frank Reichenberger; Markus G Kohstall; André Kreckel; Stefanie Krick; Henning Gall; Tobias Gessler; Thomas Schmehl; Hossein A Ghofrani; Ralph Theo Schermuly; Friedrich Grimminger; Lewis J Rubin; Werner Seeger; Horst Olschewski
Favorable effects of inhaled treprostinil in severe pulmonary hypertension: results from randomized controlled pilot studies.
Journal of the American College of Cardiology 2006;48(8):1672-81.
2006: Hossein A Ghofrani; Robert Voswinckel; Frank Reichenberger; Norbert Weissmann; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
Hypoxia- and non-hypoxia-related pulmonary hypertension - established and new therapies.
Cardiovascular research 2006;72(1):30-40.
2006: Norbert Weissmann; Natascha Sommer; Ralph Theo Schermuly; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger
Oxygen sensors in hypoxic pulmonary vasoconstriction.
Cardiovascular research 2006;71(4):620-9.
2006: Soni Pullamsetti; Daniel Maring; Hossein A Ghofrani; Konstantin Mayer; Norbert Weissmann; Bernhard Rosengarten; Martin Lehner; Christian Schudt; Rainer Boer; Friedrich Grimminger; Werner Seeger; Ralph Theo Schermuly
Effect of nitric oxide synthase (NOS) inhibition on macro- and microcirculation in a model of rat endotoxic shock.
Thrombosis and haemostasis 2006;95(4):720-7.
2006: Martin D Lehner; Degenhard Marx; Rainer Boer; Andreas Strub; Christian Hesslinger; Manfrid Eltze; Wolf-Rüdiger Ulrich; Frank Schwoebel; Ralph Theo Schermuly; Johannes Barsig
In vivo characterization of the novel imidazopyridine BYK191023 [2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine], a potent and highly selective inhibitor of inducible nitric-oxide synthase.
The Journal of pharmacology and experimental therapeutics 2006;317(1):181-7.
2006: Norbert Weissmann; Stefanie Zeller; Rolf Schäfer; Carmen Turowski; Mahmut Ay; Karin Quanz; Hossein A Ghofrani; Ralph Theo Schermuly; Ludger Fink; Werner Seeger; Friedrich Grimminger
Impact of mitochondria and NADPH oxidases on acute and sustained hypoxic pulmonary vasoconstriction.
American journal of respiratory cell and molecular biology 2006;34(4):505-13.
2006: Rajkumar Savai; Ralph Theo Schermuly; Michael Schneider; Soni Pullamsetti; Friedrich Grimminger; Werner Seeger; Gamal-Andre Banat
Hybrid-primed lymphocytes and hybrid vaccination prevent tumor growth of lewis lung carcinoma in mice.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2006;29(2):175-87.
2006: Rio Dumitrascu; Norbert Weissmann; Hossein A Ghofrani; Eva Dony; Knut Beuerlein; Harald Schmidt; Johannes-Peter Stasch; Mark J Gnoth; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling.
Circulation 2006;113(2):286-95.
2006: Ralph Theo Schermuly; Andreas Schulz; Hossein A Ghofrani; Christina Susanne Breitenbach; Norbert Weissmann; Michael Hildebrand; Julia Kurz; Friedrich Grimminger; Werner Seeger
Comparison of pharmacokinetics and vasodilatory effect of nebulized and infused iloprost in experimental pulmonary hypertension: rapid tolerance development.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 2006;19(3):353-63.
2006: Norbert Weissmann; Ralph Theo Schermuly; Hossein A Ghofrani; Jörg Hänze; Parag Goyal; Friedrich Grimminger; Werner Seeger
Hypoxic pulmonary vasoconstriction--triggered by an increase in reactive oxygen species?
Novartis Foundation symposium 2006;272():196-208; discussion 208-17.
2006: Bernhard Rosengarten; Ralph Theo Schermuly; Robert Voswinckel; Markus G Kohstall; Horst Olschewski; Norbert Weissmann; Werner Seeger; Manfred Kaps; Friedrich Grimminger; Hossein A Ghofrani
Sildenafil improves dynamic vascular function in the brain: studies in patients with pulmonary hypertension.
Cerebrovascular diseases (Basel, Switzerland) 2006;21(3):194-200.
2005: Ralph Theo Schermuly; Eva Dony; Hossein A Ghofrani; Soni Pullamsetti; Rajkumar Savai; Markus Roth; Akylbek Sydykov; Ying Ju Lai; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
Reversal of experimental pulmonary hypertension by PDGF inhibition.
The Journal of clinical investigation 2005;115(10):2811-21.
2005: Rajkumar Savai; Joachim C Wolf; Susanne Greschus; Bastian Eul; Ralph Theo Schermuly; Jörg Hänze; Robert Voswinckel; Alexander C Langheinrich; Friedrich Grimminger; Heiko Traupe; Werner Seeger; Frank Rose
Analysis of tumor vessel supply in Lewis lung carcinoma in mice by fluorescent microsphere distribution and imaging with micro- and flat-panel computed tomography.
The American journal of pathology 2005;167(4):937-46.
2005: Norbert Weissmann; Daniel Manz; Daniela Buchspies; Stephan Keller; Tanja Mehling; Robert Voswinckel; Karin Quanz; Hossein A Ghofrani; Ralph Theo Schermuly; Ludger Fink; Werner Seeger; Max Gassmann; Friedrich Grimminger
Congenital erythropoietin over-expression causes "anti-pulmonary hypertensive" structural and functional changes in mice, both in normoxia and hypoxia.
Thrombosis and haemostasis 2005;94(3):630-8.
2005: Ulrich Grandel; Michael Hopf; Michael Buerke; Katja Hattar; Martina Heep; Ludger Fink; Rainer M Bohle; Siegfried Morath; Thomas Hartung; Soni Pullamsetti; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Mechanisms of cardiac depression caused by lipoteichoic acids from Staphylococcus aureus in isolated rat hearts.
Circulation 2005;112(5):691-8.
2005: Rajkumar Savai; Ralph Theo Schermuly; Robert Voswinckel; Aparna Renigunta; Bernd Reichmann; Bastian Eul; Friedrich Grimminger; Werner Seeger; Frank Rose; Jörg Hänze
HIF-1alpha attenuates tumor growth in spite of augmented vascularization in an A549 adenocarcinoma mouse model.
International journal of oncology 2005;27(2):393-400.
2005: Ralph Theo Schermuly; Hüseyin Yilmaz; Hossein A Ghofrani; Kathrin Woyda; Soni Pullamsetti; Andreas Schulz; Tobias Gessler; Rio Dumitrascu; Norbert Weissmann; Friedrich Grimminger; Werner Seeger
Inhaled iloprost reverses vascular remodeling in chronic experimental pulmonary hypertension.
American journal of respiratory and critical care medicine 2005;172(3):358-63.
2005: Soni Pullamsetti; Ladislau Kiss; Hossein A Ghofrani; Robert Voswinckel; Peter Haredza; Walter Klepetko; Clemens Aigner; Ludger Fink; Jai Prakash Muyal; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Ralph Theo Schermuly
Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(9):1175-7.
2005: Soni Pullamsetti; Stefanie Krick; Hüseyin Yilmaz; Hossein A Ghofrani; Christian Schudt; Norbert Weissmann; Beate Fuchs; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration.
Respiratory research 2005;6():128.
2005: Norbert Weissmann; Nermin Kuzkaya; Beate Fuchs; Vedat Tiyerili; Rolf Schäfer; Hartwig Schütte; Hossein A Ghofrani; Ralph Theo Schermuly; Christian Schudt; Akylbek Sydykov; Bakytbek Egemnazarow; Werner Seeger; Friedrich Grimminger
Detection of reactive oxygen species in isolated, perfused lungs by electron spin resonance spectroscopy.
Respiratory research 2005;6():86.
2005: Ralph Theo Schermuly; Christiane Inholte; Hossein A Ghofrani; Henning Gall; Norbert Weissmann; Andreas Weidenbach; Werner Seeger; Friedrich Grimminger
Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors.
Respiratory research 2005;6():76.
2004: Hossein A Ghofrani; Robert Voswinckel; Frank Reichenberger; Horst Olschewski; Peter Haredza; Burcu Karadaş; Ralph Theo Schermuly; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective study.
Journal of the American College of Cardiology 2004;44(7):1488-96.
2004: Parag Goyal; Norbert Weissmann; Friedrich Grimminger; Cornelia Hegel; Lucius Bader; Frank Rose; Ludger Fink; Hossein A Ghofrani; Ralph Theo Schermuly; Harald Schmidt; Werner Seeger; Jörg Hänze
Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species.
Free radical biology & medicine 2004;36(10):1279-88.
2004: Horst Olschewski; Frank Rose; Ralph Theo Schermuly; Hossein A Ghofrani; Beate Enke; Andrea Olschewski; Werner Seeger
Prostacyclin and its analogues in the treatment of pulmonary hypertension.
Pharmacology & therapeutics 2004;102(2):139-53.
2004: Ralph Theo Schermuly; Klaus Peter Kreisselmeier; Hossein A Ghofrani; Arun Samidurai; Soni Pullamsetti; Norbert Weissmann; Christian Schudt; Leander Ermert; Werner Seeger; Friedrich Grimminger
Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension.
Circulation research 2004;94(8):1101-8.
2004: Norbert Weissmann; Henrik Vogels; Ralph Theo Schermuly; Hossein A Ghofrani; Jörg Hänze; Ludger Fink; Frank Rose; Werner Seeger; Friedrich Grimminger
Measurement of exhaled hydrogen peroxide from rabbit lungs.
Biological chemistry 2004;385(3-4):259-64.
2004: Hossein A Ghofrani; Georg Friese; Thomas Discher; Horst Olschewski; Ralph Theo Schermuly; Norbert Weissmann; Werner Seeger; Friedrich Grimminger; Jürgen Lohmeyer
Inhaled iloprost is a potent acute pulmonary vasodilator in HIV-related severe pulmonary hypertension.
The European respiratory journal 2004;23(2):321-6.
2004: Norbert Weissmann; Ercan Akkayagil; Karin Quanz; Ralph Theo Schermuly; Hossein A Ghofrani; Ludger Fink; Jörg Hänze; Frank Rose; Werner Seeger; Friedrich Grimminger
Basic features of hypoxic pulmonary vasoconstriction in mice.
Respiratory physiology & neurobiology 2004;139(2):191-202.
2004: Ralph Theo Schermuly; Klaus P Kreisselmeier; Hossein A Ghofrani; Hüseyin Yilmaz; Ghazwan Butrous; Leander Ermert; Monika Ermert; Norbert Weissmann; Frank Rose; Andreas Guenther; Dieter Walmrath; Werner Seeger; Friedrich Grimminger
Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats.
American journal of respiratory and critical care medicine 2004;169(1):39-45.
2003: Frank Rose; Katja Hattar; Sybille Gakisch; Friedrich Grimminger; Horst Olschewski; Werner Seeger; Annette Tschuschner; Ralph Theo Schermuly; Norbert Weissmann; Jörg Hanze; Ulf Sibelius; Hossein A Ghofrani
Increased neutrophil mediator release in patients with pulmonary hypertension--suppression by inhaled iloprost.
Thrombosis and haemostasis 2003;90(6):1141-9.
2003: Andreas Günther; Norbert Lübke; Monika Ermert; Ralph Theo Schermuly; Norbert Weissmann; Andreas Breithecker; Philipp Markart; Clemens Ruppert; Karin Quanz; Leander Ermert; Friedrich Grimminger; Werner Seeger
Prevention of bleomycin-induced lung fibrosis by aerosolization of heparin or urokinase in rabbits.
American journal of respiratory and critical care medicine 2003;168(11):1358-65.
2003: Norbert Weissmann; Nadine Ebert; Marit Ahrens; Hossein A Ghofrani; Ralph Theo Schermuly; Jörg Hänze; Ludger Fink; Frank Rose; Jörg Conzen; Werner Seeger; Friedrich Grimminger
Effects of mitochondrial inhibitors and uncouplers on hypoxic vasoconstriction in rabbit lungs.
American journal of respiratory cell and molecular biology 2003;29(6):721-32.
2003: Ralph Theo Schermuly; H Leuchte; Hossein A Ghofrani; Norbert Weissmann; Frank Rose; Markus G Kohstall; Horst Olschewski; Christian Schudt; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Zardaverine and aerosolised iloprost in a model of acute respiratory failure.
The European respiratory journal 2003;22(2):342-7.
2003: Hossein A Ghofrani; Frank Rose; Ralph Theo Schermuly; Horst Olschewski; Ralph Wiedemann; André Kreckel; Norbert Weissmann; Stefanie Ghofrani; Beate Enke; Werner Seeger; Friedrich Grimminger
Oral sildenafil as long-term adjunct therapy to inhaled iloprost in severe pulmonary arterial hypertension.
Journal of the American College of Cardiology 2003;42(1):158-64.
2003: Hossein A Ghofrani; Ralph Theo Schermuly; Frank Rose; Ralph Wiedemann; Markus G Kohstall; André Kreckel; Horst Olschewski; Norbert Weissmann; Beate Enke; Stefanie Ghofrani; Werner Seeger; Friedrich Grimminger
Sildenafil for long-term treatment of nonoperable chronic thromboembolic pulmonary hypertension.
American journal of respiratory and critical care medicine 2003;167(8):1139-41.
2003: Norbert Weissmann; Matthias Nollen; Boris Gerigk; Hossein Ardeschir Ghofrani; Ralph Theo Schermuly; Andreas Gunther; Karin Quanz; Ludger Fink; Jörg Hänze; Frank Rose; Werner Seeger; Friedrich Grimminger
Downregulation of hypoxic vasoconstriction by chronic hypoxia in rabbits: effects of nitric oxide.
American journal of physiology. Heart and circulatory physiology 2003;284(3):H931-8.
2002: Jochen Sticher; Stefan Scholz; Olav Böning; Ralph Theo Schermuly; Claudia Schumacher; Dieter Walmrath; Gunter Hempelmann
Small-dose nitric oxide improves oxygenation during one-lung ventilation: an experimental study.
Anesthesia and analgesia 2002;95(6):1557-62, table of contents.
2002: Hossein A Ghofrani; Frank Rose; Ralph Theo Schermuly; Horst Olschewski; Ralph Wiedemann; Norbert Weissmann; Christian Schudt; Hermann Tenor; Werner Seeger; Friedrich Grimminger
Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension.
Critical care medicine 2002;30(11):2489-92.
2002: Ralph Theo Schermuly; Andreas Schulz; Hossein A Ghofrani; Arne Meidow; Frank Rose; Axel Roehl; Norbert Weissmann; Michael Hildebrand; Julia Kurz; Friedrich Grimminger; Dieter Walmrath; Werner Seeger
Pharmacokinetics and metabolism of infused versus inhaled iloprost in isolated rabbit lungs.
The Journal of pharmacology and experimental therapeutics 2002;303(2):741-5.
2002: Hossein A Ghofrani; Ralph Wiedemann; Frank Rose; Ralph Theo Schermuly; Horst Olschewski; Norbert Weissmann; Andreas Gunther; Dieter Walmrath; Werner Seeger; Friedrich Grimminger
Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial.
Lancet 2002;360(9337):895-900.
2002: Hossein A Ghofrani; Ralph Wiedemann; Frank Rose; Horst Olschewski; Ralph Theo Schermuly; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension.
Annals of internal medicine 2002;136(7):515-22.
2002: Hossein A Ghofrani; Ralph Wiedemann; Frank Rose; Norbert Weissmann; Ralph Theo Schermuly; Karin Quanz; Friedrich Grimminger; Werner Seeger; Horst Olschewski
Lung cGMP release subsequent to NO inhalation in pulmonary hypertension: responders versus nonresponders.
The European respiratory journal 2002;19(4):664-71.
2001: Horst Olschewski; Frank Rose; Ekkehard Grünig; H A Ghofrani; Dieter Walmrath; R Schulz; Ralph Theo Schermuly; Friedrich Grimminger; Werner Seeger
Cellular pathophysiology and therapy of pulmonary hypertension.
The Journal of laboratory and clinical medicine 2001;138(6):367-77.
2001: Ralph Theo Schermuly; Axel Roehl; Norbert Weissmann; Hossein A Ghofrani; H Leuchte; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Combination of nonspecific PDE inhibitors with inhaled prostacyclin in experimental pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology 2001;281(6):L1361-8.
2001: Ralph Theo Schermuly; E Krupnik; Hermann Tenor; Christian Schudt; Norbert Weissmann; Frank Rose; Friedrich Grimminger; Werner Seeger; Dieter Walmrath; Hossein A Ghofrani
Coaerosolization of phosphodiesterase inhibitors markedly enhances the pulmonary vasodilatory response to inhaled iloprost in experimental pulmonary hypertension. Maintenance of lung selectivity.
American journal of respiratory and critical care medicine 2001;164(9):1694-700.
2001: Horst Olschewski; Andrea Olschewski; Frank Rose; Ralph Theo Schermuly; Hartwig Schütte; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
Physiologic basis for the treatment of pulmonary hypertension.
The Journal of laboratory and clinical medicine 2001;138(5):287-97.
2001: Ralph Wiedemann; Hossein A Ghofrani; Norbert Weissmann; Ralph Theo Schermuly; Karin Quanz; Friedrich Grimminger; Werner Seeger; Horst Olschewski
Atrial natriuretic peptide in severe primary and nonprimary pulmonary hypertension: response to iloprost inhalation.
Journal of the American College of Cardiology 2001;38(4):1130-6.
2001: Ralph Theo Schermuly; Norbert Weissmann; Beate Enke; Hossein A Ghofrani; W G Forssmann; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Urodilatin, a natriuretic peptide stimulating particulate guanylate cyclase, and the phosphodiesterase 5 inhibitor dipyridamole attenuate experimental pulmonary hypertension: synergism upon coapplication.
American journal of respiratory cell and molecular biology 2001;25(2):219-25.
2001: Hossein A Ghofrani; Markus G Kohstall; Norbert Weissmann; Thomas Schmehl; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
Alveolar epithelial barrier functions in ventilated perfused rabbit lungs.
American journal of physiology. Lung cellular and molecular physiology 2001;280(5):L896-904.
2001: Ralph Theo Schermuly; Andreas Günther; Monika Ermert; Leander Ermert; Hossein A Ghofrani; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Conebulization of surfactant and urokinase restores gas exchange in perfused lungs with alveolar fibrin formation.
American journal of physiology. Lung cellular and molecular physiology 2001;280(4):L792-800.
2001: Norbert Weissmann; S Winterhalder; Matthias Nollen; Robert Voswinckel; Karin Quanz; Hossein A Ghofrani; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
NO and reactive oxygen species are involved in biphasic hypoxic vasoconstriction of isolated rabbit lungs.
American journal of physiology. Lung cellular and molecular physiology 2001;280(4):L638-45.
2000: Norbert Weissmann; A Tadic; Jörg Hänze; Frank Rose; S Winterhalder; Matthias Nollen; Ralph Theo Schermuly; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger
Hypoxic vasoconstriction in intact lungs: a role for NADPH oxidase-derived H(2)O(2)?
American journal of physiology. Lung cellular and molecular physiology 2000;279(4):L683-90.
2000: Norbert Weissmann; Robert Voswinckel; A Tadic; T Hardebusch; Hossein A Ghofrani; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
Nitric oxide (NO)-dependent but not NO-independent guanylate cyclase activation attenuates hypoxic vasoconstriction in rabbit lungs.
American journal of respiratory cell and molecular biology 2000;23(2):222-7.
2000: Friedrich Grimminger; Frank Rose; H A Ghofrani; Ralph Theo Schermuly; N Weissmann; H Olschewski; Dieter Walmrath; W Seeger
[Inhalative strategies for improvement of pulmonary hemodynamics and gas exchange in sepsis and severe pulmonary hypertension].
Zeitschrift für Kardiologie 2000;89(6):477-84.
2000: Horst Olschewski; Hossein A Ghofrani; Dieter Walmrath; Ralph Theo Schermuly; Bettina Temmesfeld-Wollbrück; Friedrich Grimminger; W Seeger
[Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to pulmonary fibrosis].
Pneumologie (Stuttgart, Germany) 2000;54(3):133-42.
2000: Ralph Theo Schermuly; Axel Roehl; Norbert Weissmann; Hossein A Ghofrani; Christian Schudt; Hermann Tenor; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Subthreshold doses of specific phosphodiesterase type 3 and 4 inhibitors enhance the pulmonary vasodilatory response to nebulized prostacyclin with improvement in gas exchange.
The Journal of pharmacology and experimental therapeutics 2000;292(2):512-20.
2000: Ralph Theo Schermuly; Andreas Günther; Norbert Weissmann; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger; Dieter Walmrath
Differential impact of ultrasonically nebulized versus tracheal-instilled surfactant on ventilation-perfusion (VA/Q) mismatch in a model of acute lung injury.
American journal of respiratory and critical care medicine 2000;161(1):152-9.
1999: Ralph Theo Schermuly; Hossein A Ghofrani; Beate Enke; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Christian Schudt; Dieter Walmrath
Low-dose systemic phosphodiesterase inhibitors amplify the pulmonary vasodilatory response to inhaled prostacyclin in experimental pulmonary hypertension.
American journal of respiratory and critical care medicine 1999;160(5 Pt 1):1500-6.
1999: Horst Olschewski; Hossein A Ghofrani; Dieter Walmrath; Ralph Theo Schermuly; B Temmesfeld-Wollbruck; Friedrich Grimminger; Werner Seeger
Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis.
American journal of respiratory and critical care medicine 1999;160(2):600-7.
1999: Norbert Weissmann; Robert Voswinckel; T Hardebusch; Simone Rosseau; Hossein A Ghofrani; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
Evidence for a role of protein kinase C in hypoxic pulmonary vasoconstriction.
The American journal of physiology 1999;276(1 Pt 1):L90-5.
1998: Horst Olschewski; Dieter Walmrath; Ralph Theo Schermuly; Hossein A Ghofrani; Friedrich Grimminger; Werner Seeger
[Prostacyclin and iloprost in aerosol form in severe pulmonary hypertension].
Pneumologie (Stuttgart, Germany) 1998;52(1):3-7.
1997: Ralph Theo Schermuly; Thomas Schmehl; Andreas Günther; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Ultrasonic nebulization for efficient delivery of surfactant in a model of acute lung injury. Impact on gas exchange.
American journal of respiratory and critical care medicine 1997;156(2 Pt 1):445-53.
1997: Dieter Walmrath; Ralph Theo Schermuly; J Pilch; Friedrich Grimminger; Werner Seeger
Effects of inhaled versus intravenous vasodilators in experimental pulmonary hypertension.
The European respiratory journal 1997;10(5):1084-92.
1996: Dieter Walmrath; Andreas Günther; Hossein A Ghofrani; Ralph Theo Schermuly; T Schneider; Friedrich Grimminger; Werner Seeger
Bronchoscopic surfactant administration in patients with severe adult respiratory distress syndrome and sepsis.
American journal of respiratory and critical care medicine 1996;154(1):57-62.
1996: Horst Olschewski; Dieter Walmrath; Ralph Theo Schermuly; A Ghofrani; Friedrich Grimminger; Werner Seeger
Aerosolized prostacyclin and iloprost in severe pulmonary hypertension.
Annals of internal medicine 1996;124(9):820-4.
1996: Dieter Walmrath; T Schneider; Ralph Theo Schermuly; Horst Olschewski; Friedrich Grimminger; Werner Seeger
Direct comparison of inhaled nitric oxide and aerosolized prostacyclin in acute respiratory distress syndrome.
American journal of respiratory and critical care medicine 1996;153(3):991-6.
1995: Dieter Walmrath; T Schneider; J Pilch; Ralph Theo Schermuly; Friedrich Grimminger; Werner Seeger
Effects of aerosolized prostacyclin in severe pneumonia. Impact of fibrosis.
American journal of respiratory and critical care medicine 1995;151(3 Pt 1):724-30.
1993: E Petzinger; W Föllmann; M Blumrich; Ralph Theo Schermuly; S Schulz; J Hahnen; P W Feit
Interaction of bumetanide derivatives with hepatocellular bile acid uptake.
The American journal of physiology 1993;265(5 Pt 1):G942-54.