FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Donalyn Scheuner

Research Profile

Chemicals & Drugs

Living Beings

Phenomena

Phosphorylation

Physiology

Anatomy

Co-author Network

Publications

TOP 3
Hala Muaddi; Mithu Majumder; Philippos Peidis; Andreas I Papadakis; Martin Holcik; Donalyn Scheuner; Randal J Kaufman; Maria Hatzoglou; Antonis E Koromilas
Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.
Elena Bevilacqua; Xinglong Wang; Mithu Majumder; Francesca Gaccioli; Celvie L Yuan; Chuanping Wang; Xiongwei Zhu; Lindsay E Jordan; Donalyn Scheuner; Randal J Kaufman; Antonis E Koromilas; Martin D Snider; Martin Holcik; Maria Hatzoglou
eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress.
Oliver Schulz; Andreas Pichlmair; Jan Rehwinkel; Neil C Rogers; Donalyn Scheuner; Hiroki Kato; Osamu Takeuchi; Shizuo Akira; Randal J Kaufman; Caetano Reis e Sousa
Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Donalyn Scheuner (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2010: Hala Muaddi; Mithu Majumder; Philippos Peidis; Andreas I Papadakis; Martin Holcik; Donalyn Scheuner; Randal J Kaufman; Maria Hatzoglou; Antonis E Koromilas
Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.
Molecular biology of the cell 2010;21(18):3220-31.
2010: Elena Bevilacqua; Xinglong Wang; Mithu Majumder; Francesca Gaccioli; Celvie L Yuan; Chuanping Wang; Xiongwei Zhu; Lindsay E Jordan; Donalyn Scheuner; Randal J Kaufman; Antonis E Koromilas; Martin D Snider; Martin Holcik; Maria Hatzoglou
eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress.
The Journal of biological chemistry 2010;285(22):17098-111.
2010: Oliver Schulz; Andreas Pichlmair; Jan Rehwinkel; Neil C Rogers; Donalyn Scheuner; Hiroki Kato; Osamu Takeuchi; Shizuo Akira; Randal J Kaufman; Caetano Reis e Sousa
Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity.
Cell host & microbe 2010;7(5):354-61.
2009: Jenny B DuRose; Donalyn Scheuner; Randal J Kaufman; Lawrence I Rothblum; Maho Niwa
Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress.
Molecular and cellular biology 2009;29(15):4295-307.
2009: Sung Hoon Back; Donalyn Scheuner; Jaeseok Han; Benbo Song; Mark Ribick; Junying Wang; Robert D Gildersleeve; Subramaniam Pennathur; Randal J Kaufman
Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells.
Cell metabolism 2009;10(1):13-26.
2009: Heather P Harding; Yuhong Zhang; Donalyn Scheuner; Jane-Jane Chen; Randal J Kaufman; David Ron
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(6):1832-7.
2009: Zineb Mounir; Jothi Latha Krishnamoorthy; Gavin P Robertson; Donalyn Scheuner; Randal J Kaufman; Maria-Magdalena Georgescu; Antonis E Koromilas
Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway.
Science signaling 2009;2(102):ra85.
2008: Benbo Song; Donalyn Scheuner; David Ron; Subramaniam Pennathur; Randal J Kaufman
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.
The Journal of clinical investigation 2008;118(10):3378-89.
2008: Baldwin C Mak; Qin Wang; Carol A Laschinger; Wilson Lee; David Ron; Heather P Harding; Randal J Kaufman; Donalyn Scheuner; Richard C Austin; Christopher A McCulloch
Novel function of PERK as a mediator of force-induced apoptosis.
The Journal of biological chemistry 2008;283(34):23462-72.
2008: Donalyn Scheuner; Randal J Kaufman
The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes.
Endocrine reviews 2008;29(3):317-33.
2007: Dirk Vander Mierde; Donalyn Scheuner; Roel Quintens; Rupali Patel; Benbo Song; Katsura Tsukamoto; Monique Beullens; Randal J Kaufman; Mathieu Bollen; Frans Schuit
Glucose activates a protein phosphatase-1-mediated signaling pathway to enhance overall translation in pancreatic beta-cells.
Endocrinology 2007;148(2):609-17.
2006: Donalyn Scheuner; Rupali Patel; Feng Wang; Kuei Lee; Kotlo Kumar; Jun Wu; Anders Nilsson; Michael Karin; Randal J Kaufman
Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis.
The Journal of biological chemistry 2006;281(30):21458-68.
2005: Heather P Harding; Yuhong Zhang; Sonya Khersonsky; Stefan Marciniak; Donalyn Scheuner; Randal J Kaufman; Norman B Javitt; Young-Tae Chang; David Ron
Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression.
Cell metabolism 2005;2(6):361-71.
2005: Meixia Bi; Christine Naczki; Marianne Koritzinsky; Diane R Fels; Jaime Blais; Nianping Hu; Heather P Harding; Isabel Novoa; Mahesh Varia; James Raleigh; Donalyn Scheuner; Randal J Kaufman; John Bell; David Ron; Bradly G Wouters; Constantinos Koumenis
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth.
The EMBO journal 2005;24(19):3470-81.
2005: Donalyn Scheuner; Dirk Vander Mierde; Benbo Song; Daisy Flamez; John W M Creemers; Katsura Tsukamoto; Mark Ribick; Frans Schuit; Randal J Kaufman
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis.
Nature medicine 2005;11(7):757-64.
2005: Nancy Kedersha; Georg Stoecklin; Maranatha Ayodele; Patrick Yacono; Jens Lykke-Andersen; Marvin Fritzler; Donalyn Scheuner; Randal J Kaufman; David E Golan; Paul Anderson
Stress granules and processing bodies are dynamically linked sites of mRNP remodeling.
The Journal of cell biology 2005;169(6):871-84.
2005: Edward McEwen; Nancy Kedersha; Benbo Song; Donalyn Scheuner; Natalie Gilks; Anping Han; Jane-Jane Chen; Paul Anderson; Randal J Kaufman
Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure.
The Journal of biological chemistry 2005;280(17):16925-33.
2005: Michael Boyce; Kevin F Bryant; Céline Jousse; Kai Long; Heather P Harding; Donalyn Scheuner; Randal J Kaufman; Dawei Ma; Donald M Coen; David Ron; Junying Yuan
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
Science (New York, N.Y.) 2005;307(5711):935-9.
2005: Kezhong Zhang; Hetty N Wong; Benbo Song; Corey N Miller; Donalyn Scheuner; Randal J Kaufman
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.
The Journal of clinical investigation 2005;115(2):268-81.
2004: Jing Deng; Phoebe D Lu; Yuhong Zhang; Donalyn Scheuner; Randal J Kaufman; Nahum Sonenberg; Heather P Harding; David Ron
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2.
Molecular and cellular biology 2004;24(23):10161-8.
2004: Shiyong Wu; Mingjia Tan; Yuanyuan Hu; Ju-Lin Wang; Donalyn Scheuner; Randal J Kaufman
Ultraviolet light activates NFkappaB through translational inhibition of IkappaBalpha synthesis.
The Journal of biological chemistry 2004;279(33):34898-902.
2004: Phoebe D Lu; Céline Jousse; Stefan Marciniak; Yuhong Zhang; Isabel Novoa; Donalyn Scheuner; Randal J Kaufman; David Ron; Heather P Harding
Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2.
The EMBO journal 2004;23(1):169-79.
2003: Donalyn Scheuner; Matthias Gromeier; Monique V Davies; Andrew J Dorner; Benbo Song; Rupali V Patel; Eckard J Wimmer; Roger E McLendon; Randal J Kaufman
The double-stranded RNA-activated protein kinase mediates viral-induced encephalitis.
Virology 2003;317(2):263-74.
2003: Hao-Yuan Jiang; Sheree A Wek; Barbara C McGrath; Donalyn Scheuner; Randal J Kaufman; Douglas R Cavener; Ronald C Wek
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses.
Molecular and cellular biology 2003;23(16):5651-63.
2003: Ibrahim Yaman; James Fernandez; Haiyan Liu; Mark G Caprara; Anton A Komar; Antonis E Koromilas; Lingyin Zhou; Martin D Snider; Donalyn Scheuner; Randal J Kaufman; Maria Hatzoglou
The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader.
Cell 2003;113(4):519-31.
2003: Stephen L Ward; Donalyn Scheuner; Jeremy Poppers; Randal J Kaufman; Ian Mohr; David A Leib
In vivo replication of an ICP34.5 second-site suppressor mutant following corneal infection correlates with in vitro regulation of eIF2 alpha phosphorylation.
Journal of virology 2003;77(8):4626-34.
2002: Jing Deng; Heather P Harding; Brian Raught; Anne-Claude Gingras; Juan Jose Berlanga; Donalyn Scheuner; Randal J Kaufman; David Ron; Nahum Sonenberg
Activation of GCN2 in UV-irradiated cells inhibits translation.
Current biology : CB 2002;12(15):1279-86.
2002: Randal J Kaufman; Donalyn Scheuner; Martin Schröder; Xiaohua Shen; Kyungho Lee; Chuan Yin Liu; Stacey Marie Arnold
The unfolded protein response in nutrient sensing and differentiation.
Nature reviews. Molecular cell biology 2002;3(6):411-21.
2002: Zsolt Tallóczy; Wenxia Jiang; Herbert W Virgin; David A Leib; Donalyn Scheuner; Randal J Kaufman; Eeva-Liisa Eskelinen; Beth Levine
Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):190-5.
2001: Anna L Scarim; M Arnush; Libby A Blair; J Concepcion; Monique R Heitmeier; Donalyn Scheuner; Randal J Kaufman; Jan S Ryerse; R Mark L Buller; John A Corbett
Mechanisms of beta-cell death in response to double-stranded (ds) RNA and interferon-gamma: dsRNA-dependent protein kinase apoptosis and nitric oxide-dependent necrosis.
The American journal of pathology 2001;159(1):273-83.
2001: Donalyn Scheuner; Benbo Song; Edward McEwen; C Liu; R Laybutt; P Gillespie; Thomas L Saunders; S Bonner-Weir; Randal J Kaufman
Translational control is required for the unfolded protein response and in vivo glucose homeostasis.
Molecular cell 2001;7(6):1165-76.
2000: Leonard Bruno Maggi; Monique R Heitmeier; Donalyn Scheuner; Randal J Kaufman; R Mark L Buller; John A Corbett
Potential role of PKR in double-stranded RNA-induced macrophage activation.
The EMBO journal 2000;19(14):3630-8.
1999: Donald J DeGracia; S Adamczyk; Adam Folbe; L L Konkoly; J E Pittman; Robert W Neumar; Jonathon M. Sullivan; Donalyn Scheuner; Randal J Kaufman; Blaine C White; Gary S Krause
Eukaryotic initiation factor 2alpha kinase and phosphatase activity during postischemic brain reperfusion.
Experimental neurology 1999;155(2):221-7.
1996: Donalyn Scheuner; Christopher B Eckman; M Jensen; X Song; Martin Citron; N Suzuki; Thomas D Bird; John Hardy; Michael Hutton; Walter A Kukull; Eric B Larson; Ephrat Levy-Lahad; Matti Viitanen; Elaine Peskind; Parvoneh Poorkaj-Navas; Gerard D Schellenberg; Rudolph E Tanzi; Wilma Wasco; Lars Lannfelt; Dennis J Selkoe; Steven G Younkin
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.
Nature medicine 1996;2(8):864-70.
1994: Donalyn Scheuner; Ronald W Holz
Evidence that the ability to respond to a calcium stimulus in exocytosis is determined by the secretory granule membrane: comparison of exocytosis of injected bovine chromaffin granule membranes and endogenous cortical granules in Xenopus laevis oocytes.
Cellular and molecular neurobiology 1994;14(3):245-57.
1992: Donalyn Scheuner; C D Logsdon; Ronald W Holz
Bovine chromaffin granule membranes undergo Ca(2+)-regulated exocytosis in frog oocytes.
The Journal of cell biology 1992;116(2):359-65.
1989: R S Seelan; Donalyn Scheuner; Margaret I Lomax; Lawrence I Grossman
Nucleotide sequence of a cDNA for bovine cytochrome c oxidase subunit VIIa.
Nucleic acids research 1989;17(15):6410.