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Christian Scheurer

Research Profile

Chemicals & Drugs

Living Beings

Mouse
Rats

Disorders

Procedures

Parasitic Sensitivity Tests

Concepts & Ideas

Anatomy

Microsomes, Liver

Physiology

Drug Resistance

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Publications

TOP 3
Xiaofang Wang; Sergio Wittlin; Susan A Charman; Francis C K Chiu; Jacques Chollet; Yuxiang Dong; Kasiram Katneni; Janne Mannila; Julia Morizzi; Eileen Ryan; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Jessica Steuten; Jonathan L Vennerstrom
Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.
Diego González Cabrera; Jayan T Joseph; Jolanda Kamber; Kasiram Katneni; Claire Le Manach; Oliver D Montagnat; Aloysius T Nchinda; Eileen Ryan; Christian Scheurer; Leslie J Street; David Waterson; Karen L White; Sergio Wittlin; Michael J Witty; Yassir Younis; K Mohammed Zabiulla; Sridevi Bashyam; Susan A Charman; Frederic Douelle; Tzu-Shean Feng; Kelly Chibale
Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines.
Michael Delves; Stephan Meister; David Plouffe; Christian Scheurer; Robert E Sinden; Elizabeth A Winzeler; Sergio Wittlin; Didier Leroy
The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites.

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All Publications

2013: Xiaofang Wang; Sergio Wittlin; Susan A Charman; Francis C K Chiu; Jacques Chollet; Yuxiang Dong; Kasiram Katneni; Janne Mannila; Julia Morizzi; Eileen Ryan; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Jessica Steuten; Jonathan L Vennerstrom
Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.
Journal of medicinal chemistry 2013;56(6):2547-55.
2012: Diego González Cabrera; Jayan T Joseph; Jolanda Kamber; Kasiram Katneni; Claire Le Manach; Oliver D Montagnat; Aloysius T Nchinda; Eileen Ryan; Christian Scheurer; Leslie J Street; David Waterson; Karen L White; Sergio Wittlin; Michael J Witty; Yassir Younis; K Mohammed Zabiulla; Sridevi Bashyam; Susan A Charman; Frederic Douelle; Tzu-Shean Feng; Kelly Chibale
Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines.
Journal of medicinal chemistry 2012;55(24):11022-30.
2012: Michael Delves; Stephan Meister; David Plouffe; Christian Scheurer; Robert E Sinden; Elizabeth A Winzeler; Sergio Wittlin; Didier Leroy
The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites.
PLoS medicine 2012;9(2):e1001169.
2012: Tanja Wenzler; Sergio Wittlin; Reto Brun; Christian Scheurer; Andrea Steinhuber; Andrej Trampuz
Isothermal microcalorimetry, a new tool to monitor drug action against Trypanosoma brucei and Plasmodium falciparum.
PLoS neglected tropical diseases 2012;6(6):e1668.
2011: Susan A Charman; Sarah Arbe-Barnes; Ian C Bathurst; Reto Brun; Michael Campbell; William N Charman; Francis C K Chiu; Jacques Chollet; J Carl Craft; Darren J Creek; Yuxiang Dong; Hugues Matile; Melanie Maurer; Julia Morizzi; Tien Nguyen; Petros Papastogiannidis; Christian Scheurer; David M Shackleford; Kamaraj Sriraghavan; Lukas Stingelin; Yuanqing Tang; Heinrich Urwyler; Xiaofang Wang; Karen L White; Sergio Wittlin; Lin Zhou; Jonathan L Vennerstrom
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(11):4400-5.
2010: Yuanqing Tang; Sergio Wittlin; Susan A Charman; Jacques Chollet; Francis C K Chiu; Julia Morizzi; Lisa M Johnson; Josefina Santo Tomas; Christian Scheurer; Chistopher Snyder; Lin Zhou; Yuxiang Dong; William N Charman; Hugues Matile; Heinrich Urwyler; Arnulf Dorn; Jonathan L Vennerstrom
The comparative antimalarial properties of weak base and neutral synthetic ozonides.
Bioorganic & medicinal chemistry letters 2010;20(2):563-6.
2010: Yuxiang Dong; Sergio Wittlin; Kamaraj Sriraghavan; Jacques Chollet; Susan A Charman; William N Charman; Christian Scheurer; Heinrich Urwyler; Josefina Santo Tomas; Christopher Snyder; Darren J Creek; Julia Morizzi; Maria Koltun; Hugues Matile; Xiaofang Wang; Maniyan Padmanilayam; Yuanqing Tang; Arnulf Dorn; Reto Brun; Jonathan L Vennerstrom
The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).
Journal of medicinal chemistry 2010;53(1):481-91.
2009: Xiaofang Wang; Darren J Creek; Charles E Schiaffo; Yuxiang Dong; Jacques Chollet; Christian Scheurer; Sergio Wittlin; Susan A Charman; Patrick H Dussault; James K Wood; Jonathan L Vennerstrom
Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity.
Bioorganic & medicinal chemistry letters 2009;19(16):4542-5.
2008: Sandra Hofer; Reto Brun; Sonja Maerki; Hugues Matile; Christian Scheurer; Sergio Wittlin
In vitro assessment of the pharmacodynamic properties of DB75, piperaquine, OZ277 and OZ401 in cultures of Plasmodium falciparum.
The Journal of antimicrobial chemotherapy 2008;62(5):1061-4.
2008: Lin Zhou; André Alker; Armin Ruf; Xiaofang Wang; Francis C K Chiu; Julia Morizzi; Susan A Charman; William N Charman; Christian Scheurer; Sergio Wittlin; Yuxiang Dong; Daniel Hunziker; Jonathan L Vennerstrom
Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277.
Bioorganic & medicinal chemistry letters 2008;18(5):1555-8.
2007: Xiaofang Wang; Yuxiang Dong; Sergio Wittlin; Darren J Creek; Jacques Chollet; Susan A Charman; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Jonathan L Vennerstrom
Spiro- and dispiro-1,2-dioxolanes: contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides.
Journal of medicinal chemistry 2007;50(23):5840-7.
2007: Lyda Osorio; Claribel Murillo; Samanda Aponte; Valeriana Mayagaya; Christian Scheurer; Reto Brun; Hugues Matile; Sergio Wittlin
In vitro susceptibility of P. falciparum populations from Colombia and Tanzania to a new synthetic peroxide (OZ277).
The American journal of tropical medicine and hygiene 2007;76(6):1024-6.
2007: Christopher Snyder; Jacques Chollet; Josefina Santo Tomas; Christian Scheurer; Sergio Wittlin
In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models.
Experimental parasitology 2007;115(3):296-300.
2006: Maniyan Padmanilayam; Bernard Scorneaux; Yuxiang Dong; Jacques Chollet; Hugues Matile; Susan A Charman; Darren J Creek; William N Charman; Josefina Santo Tomas; Christian Scheurer; Sergio Wittlin; Reto Brun; Jonathan L Vennerstrom
Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine.
Bioorganic & medicinal chemistry letters 2006;16(21):5542-5.
2006: Yuxiang Dong; Yuanqing Tang; Jacques Chollet; Hugues Matile; Sergio Wittlin; Susan A Charman; William N Charman; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Bernard Scorneaux; Saroj Bajpai; Scott A Alexander; Xiaofang Wang; Maniyan Padmanilayam; Srinivasa R Cheruku; Reto Brun; Jonathan L Vennerstrom
Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes.
Bioorganic & medicinal chemistry 2006;14(18):6368-82.
2006: Clemens H M Kocken; Annemarie van der Wel; Sarah Arbe-Barnes; Reto Brun; Hugues Matile; Christian Scheurer; Sergio Wittlin; Alan Thomas
Plasmodium vivax: in vitro susceptibility of blood stages to synthetic trioxolane compounds and the diamidine DB75.
Experimental parasitology 2006;113(3):197-200.
2005: Yuxiang Dong; Jacques Chollet; Hugues Matile; Susan A Charman; Francis C K Chiu; William N Charman; Bernard Scorneaux; Heinrich Urwyler; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Arnulf Dorn; Xiaofang Wang; Jean M Karle; Yuanqing Tang; Sergio Wittlin; Reto Brun; Jonathan L Vennerstrom
Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.
Journal of medicinal chemistry 2005;48(15):4953-61.
2004: Jonathan L Vennerstrom; Sarah Arbe-Barnes; Reto Brun; Susan A Charman; Francis C K Chiu; Jacques Chollet; Yuxiang Dong; Arnulf Dorn; Daniel Hunziker; Hugues Matile; Kylie McIntosh; Maniyan Padmanilayam; Josefina Santo Tomas; Christian Scheurer; Bernard Scorneaux; Yuanqing Tang; Heinrich Urwyler; Sergio Wittlin; William N Charman
Identification of an antimalarial synthetic trioxolane drug development candidate.
Nature 2004;430(7002):900-4.