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Bernhard Schiedlmeier

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Ulrika Blank; Ann Brun; Birgitta Ehrnström; Niels Heinz; Eva Nilsson; Bernhard Schiedlmeier; Christopher Baum; Stefan Karlsson
Angptl4 maintains in vivo repopulation capacity of CD34+ human cord blood cells.
Dietrich Armin Lesinski; Sandra Pilat-Carotta; Cornelia Rudolph; Niels Heinz; Roland Jacobs; Hannes Klump; Brigitte Schlegelberger; Bernhard Schiedlmeier
Serum- and stromal cell-free hypoxic generation of embryonic stem cell-derived hematopoietic cells in vitro, capable of multilineage repopulation of immunocompetent mice.
Soeren Turan; Melanie Galla; Ellen Ernst; Junhua Qiao; Christine Voelkel; Bernhard Schiedlmeier; Christoph Zehe; Juergen Bode
Recombinase-mediated cassette exchange (RMCE): traditional concepts and current challenges.

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2012: Ulrika Blank; Ann Brun; Birgitta Ehrnström; Niels Heinz; Eva Nilsson; Bernhard Schiedlmeier; Christopher Baum; Stefan Karlsson
Angptl4 maintains in vivo repopulation capacity of CD34+ human cord blood cells.
European journal of haematology 2012;89(3):198-205.
2012: Dietrich Armin Lesinski; Sandra Pilat-Carotta; Cornelia Rudolph; Niels Heinz; Roland Jacobs; Hannes Klump; Brigitte Schlegelberger; Bernhard Schiedlmeier
Serum- and stromal cell-free hypoxic generation of embryonic stem cell-derived hematopoietic cells in vitro, capable of multilineage repopulation of immunocompetent mice.
Stem cells translational medicine 2012;1(8):581-91.
2011: Soeren Turan; Melanie Galla; Ellen Ernst; Junhua Qiao; Christine Voelkel; Bernhard Schiedlmeier; Christoph Zehe; Juergen Bode
Recombinase-mediated cassette exchange (RMCE): traditional concepts and current challenges.
Journal of molecular biology 2011;407(2):193-221.
2011: Tobias Maetzig; Martijn Brugman; Stefan Bartels; Niels Heinz; Olga S Kustikova; Ute Modlich; Zhixiong Li; Melanie Galla; Bernhard Schiedlmeier; Axel Schambach; Christopher Baum
Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells.
Blood 2011;117(11):3053-64.
2011: Niels Heinz; Axel Schambach; Melanie Galla; Tobias Maetzig; Christopher Baum; Rainer Loew; Bernhard Schiedlmeier
Retroviral and transposon-based tet-regulated all-in-one vectors with reduced background expression and improved dynamic range.
Human gene therapy 2011;22(2):166-76.
2010: Carol Stocking; Manuel Grez; Boris Fehse; Dorothee von Laer; Katsuhiko Itoh; Vladimir Prassolov; Joachim Nowock; Klaus Kühlcke; Ursula Just; Timm Schröder; Hannes Klump; Bernhard Schiedlmeier; Elke Grassman; Johann Meyer; Zhixiong Li; Axel Schambach; Ute Modlich; Olga Kustikova; Melanie Galla; Jürgen Bode; Axel Zander; Christopher Baum
Cell and virus genetics at the roots of gene therapy, retrovirology, and hematopoietic stem cell biology: Wolfram Ostertag (1937-2010).
Human gene therapy 2010;21(11):1501-3.
2009: Olga S Kustikova; Bernhard Schiedlmeier; Martijn Brugman; Maike Stahlhut; Stefan Bartels; Zhixiong Li; Christopher Baum
Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(9):1537-47.
2009: Michael D Milsom; Bernhard Schiedlmeier; Jeff Bailey; Mi-Ok Kim; Dandan Li; Michael Jansen; Abdullah Ali; Michelle Kirby; Christopher Baum; Leslie J Fairbairn; David A Williams
Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-{alpha} on Fanconi anemia hematopoietic stem and progenitor cells.
Blood 2009;113(21):5111-20.
2009: Ute Modlich; Axel Schambach; Zhixiong Li; Bernhard Schiedlmeier
Murine hematopoietic stem cell transduction using retroviral vectors.
Methods in molecular biology (Clifton, N.J.) 2009;506():23-31.
2008: Susannah I Thornhill; Axel Schambach; Steven J Howe; Meera Ulaganathan; Elke Grassman; David Williams; Bernhard Schiedlmeier; Neil J Sebire; H Bobby Gaspar; Christine Kinnon; Christopher Baum; Adrian J Thrasher
Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(3):590-8.
2007: Bernhard Schiedlmeier; Ana Cristina Santos; Ana Ribeiro; Natalia Moncaut; Dietrich Lesinski; Herbert Auer; Karl Kornacker; Wolfram Ostertag; Christopher Baum; Moises Mallo; Hannes Klump
HOXB4's road map to stem cell expansion.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):16952-7.
2007: Johann Meyer; M Rhein; Bernhard Schiedlmeier; Olga S Kustikova; Cornelia Rudolph; Kenji Kamino; T Neumann; M Yang; Anke Wahlers; Boris Fehse; Gary W Reuther; Brigitte Schlegelberger; Arnold Ganser; Christopher Baum; Zhixiong Li
Remarkable leukemogenic potency and quality of a constitutively active neurotrophin receptor, deltaTrkA.
Leukemia 2007;21(10):2171-80.
2006: Axel Schambach; Bernhard Schiedlmeier; Klaus Kühlcke; M Verstegen; Geoffrey P Margison; Zhixiong Li; K Kamino; Jens Bohne; Alexander Alexandrov; Felix Hermann; Dorothee von Laer; Christopher Baum
Towards hematopoietic stem cell-mediated protection against infection with human immunodeficiency virus.
Gene therapy 2006;13(13):1037-47.
2006: Jutta Friel; Bernhard Schiedlmeier; Maren Geldmacher; Wolfram Ostertag
Stromal cells selectively reduce the growth advantage of human committed CD34+ hematopoietic cells ectopically expressing HOXB4.
Growth factors (Chur, Switzerland) 2006;24(2):97-105.
2006: Elke Will; Daniel Speidel; Zheng Wang; Gabriel Ghiaur; Andreas Rimek; Bernhard Schiedlmeier; David A Williams; Christopher Baum; Wolfram Ostertag; Hannes Klump
HOXB4 inhibits cell growth in a dose-dependent manner and sensitizes cells towards extrinsic cues.
Cell cycle (Georgetown, Tex.) 2006;5(1):14-22.
2005: Sandra Pilat; Sebastian Carotta; Bernhard Schiedlmeier; Kenji Kamino; Andreas Mairhofer; Elke Will; Ute Modlich; Peter Steinlein; Wolfram Ostertag; Christopher Baum; Hartmut Beug; Hannes Klump
HOXB4 enforces equivalent fates of ES-cell-derived and adult hematopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(34):12101-6.
2005: Hannes Klump; Bernhard Schiedlmeier; Christopher Baum
Control of self-renewal and differentiation of hematopoietic stem cells: HOXB4 on the threshold.
Annals of the New York Academy of Sciences 2005;1044():6-15.
2005: Jörg Bäsecke; Maike Schwieger; Frank Griesinger; Bernhard Schiedlmeier; Gerald Wulf; Lorenz Trümper; Carol Stocking
AML1/ETO promotes the maintenance of early hematopoietic progenitors in NOD/SCID mice but does not abrogate their lineage specific differentiation.
Leukemia & lymphoma 2005;46(2):265-72.
2003: Zhixiong Li; Maike Schwieger; Claudia Lange; Janine Kraunus; Hanying Sun; Eric van den Akker; Ute Modlich; Ebru Serinsöz; Elke Will; Dorothee von Laer; Carol Stocking; Boris Fehse; Bernhard Schiedlmeier; Christopher Baum
Predictable and efficient retroviral gene transfer into murine bone marrow repopulating cells using a defined vector dose.
Experimental hematology 2003;31(12):1206-14.
2003: Stephanie Laufs; Bernhard Gentner; K Zsuzsanna Nagy; Anna Jauch; Axel Benner; Sonja Naundorf; Klaus Kuehlcke; Bernhard Schiedlmeier; Anthony Ho; W Jens Zeller; Stefan Fruehauf
Retroviral vector integration occurs in preferred genomic targets of human bone marrow-repopulating cells.
Blood 2003;101(6):2191-8.
2003: Bernhard Schiedlmeier; Hannes Klump; Elke Will; Gökhan Arman-Kalcek; Zhixiong Li; Zheng Wang; Andreas Rimek; Jutta Friel; Christopher Baum; Wolfram Ostertag
High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation.
Blood 2003;101(5):1759-68.
2002: Anke Wahlers; Olga S Kustikova; Peter F Zipfel; Katsuhiko Itoh; Markus Koester; Christoph Heberlein; Zhixiong Li; Bernhard Schiedlmeier; Christine Skerka; Boris Fehse; Christopher Baum
Upstream conserved sequences of mouse leukemia viruses are important for high transgene expression in lymphoid and hematopoietic cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(3):313-20.
2002: Zhixiong Li; Boris Fehse; Bernhard Schiedlmeier; Jochen Düllmann; O Frank; A R Zander; Wolfram Ostertag; Christopher Baum
Persisting multilineage transgene expression in the clonal progeny of a hematopoietic stem cell.
Leukemia 2002;16(9):1655-63.
2002: Elke Will; Hannes Klump; Nicole Heffner; Maike Schwieger; Bernhard Schiedlmeier; Wolfram Ostertag; Christopher Baum; Carol Stocking
Unmodified Cre recombinase crosses the membrane.
Nucleic acids research 2002;30(12):e59.
2002: Zhixiong Li; Jochen Düllmann; Bernhard Schiedlmeier; Manfred Schmidt; Christof von Kalle; Johann Meyer; Martin Forster; Carol Stocking; Anke Wahlers; Oliver Frank; Wolfram Ostertag; Klaus Kühlcke; Hans-Georg Eckert; Boris Fehse; Christopher Baum
Murine leukemia induced by retroviral gene marking.
Science (New York, N.Y.) 2002;296(5567):497.
2002: Bernhard Schiedlmeier; Andrea Schilz; Klaus Kühlcke; Stephanie Laufs; Christopher Baum; W Jens Zeller; Hans-Georg Eckert; Stefan Fruehauf
Multidrug resistance 1 gene transfer can confer chemoprotection to human peripheral blood progenitor cells engrafted in immunodeficient mice.
Human gene therapy 2002;13(2):233-42.
2002: Michaela Scherr; Karin Battmer; Ulrike Blömer; Bernhard Schiedlmeier; Arnold Ganser; Manuel Grez; Matthias Eder
Lentiviral gene transfer into peripheral blood-derived CD34+ NOD/SCID-repopulating cells.
Blood 2002;99(2):709-12.
2001: Eike C Buss; Bernhard Schiedlmeier; Anthony Ho; W Jens Zeller; Stefan Fruehauf
The FBMD-1 stroma cell line secretes a unique moiety which can increase retroviral transduction of lineage-committed and primitive human peripheral blood progenitor cells.
Cancer gene therapy 2001;8(6):440-9.
2001: Hannes Klump; Bernhard Schiedlmeier; B Vogt; M Ryan; Wolfram Ostertag; Christopher Baum
Retroviral vector-mediated expression of HoxB4 in hematopoietic cells using a novel coexpression strategy.
Gene therapy 2001;8(10):811-7.
2001: R Knipper; Klaus Kuehlcke; Bernhard Schiedlmeier; M Hildinger; Carsten Lindemann; Andrea Schilz; Axel A Fauser; Stefan Fruehauf; W Jens Zeller; Wolfram Ostertag; Hans-Georg Eckert; Christopher Baum
Improved post-transcriptional processing of an MDR1 retrovirus elevates expression of multidrug resistance in primary human hematopoietic cells.
Gene therapy 2001;8(3):239-46.
2000: Andrea Schilz; Bernhard Schiedlmeier; Klaus Kühlcke; Stefan Fruehauf; Carsten Lindemann; W Jens Zeller; Manuel Grez; Axel A Fauser; Christopher Baum; Hans-Georg Eckert
MDR1 gene expression in NOD/SCID repopulating cells after retroviral gene transfer under clinically relevant conditions.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;2(6):609-18.
2000: Bernhard Schiedlmeier; K Wermann; Klaus Kühlcke; Hans-Georg Eckert; Christopher Baum; Stefan Fruehauf; W Jens Zeller
Human multidrug resistance-1 gene transfer to long-term repopulating human mobilized peripheral blood progenitor cells.
Bone marrow transplantation 2000;25 Suppl 2():S118-24.
2000: Marlon R Veldwijk; Stefan Fruehauf; Bernhard Schiedlmeier; Jürgen A Kleinschmidt; W Jens Zeller
Differential expression of a recombinant adeno-associated virus 2 vector in human CD34+ cells and breast cancer cells.
Cancer gene therapy 2000;7(4):597-604.
2000: Bernhard Schiedlmeier; Klaus Kühlcke; Hans-Georg Eckert; Christopher Baum; W Jens Zeller; Stefan Fruehauf
Quantitative assessment of retroviral transfer of the human multidrug resistance 1 gene to human mobilized peripheral blood progenitor cells engrafted in nonobese diabetic/severe combined immunodeficient mice.
Blood 2000;95(4):1237-48.
1999: Marlon R Veldwijk; Bernhard Schiedlmeier; Jürgen A Kleinschmidt; W Jens Zeller; Stefan Fruehauf
Superior gene transfer into solid tumour cells than into human mobilised peripheral blood progenitor cells using helpervirus-free adeno-associated viral vector stocks.
European journal of cancer (Oxford, England : 1990) 1999;35(7):1136-42.
1999: Bernhard Schiedlmeier; Eike C Buss; Marlon R Veldwijk; W Jens Zeller; Stefan Fruehauf
Soluble bone marrow stroma factors improve the efficiency of retroviral transfer of the human multidrug resistance 1 gene to human mobilized peripheral blood progenitor cells.
Human gene therapy 1999;10(9):1443-52.
1999: B Kasper; Stefan Fruehauf; Bernhard Schiedlmeier; E Buchdunger; Anthony Ho; W Jens Zeller
Favorable therapeutic index of a p210(BCR-ABL)-specific tyrosine kinase inhibitor; activity on lineage-committed and primitive chronic myelogenous leukemia progenitors.
Cancer chemotherapy and pharmacology 1999;44(5):433-8.