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Michael Blackman

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Christine R Collins; Fiona Hackett; Maria Penzo; M Strath; Chrislaine Withers-Martinez; David A Baker; Michael J Blackman
Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress.
Christine R Collins; Sujaan Das; Fiona Hackett; Jean-Paul Herman; Markus Meissner; Sylke Müller; Robert Stallmach; Eleanor H Wong; Nicole Andenmatten; Michael J Blackman
Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle.
Robert W Moon; Arnab Pain; Farania Rangkuti; Neil Almond; Joanna Hall; Yung Shwen Ho; Anthony A Holder; Graham H Mitchell; Michael J Blackman
Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes.

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All Publications

2013: Christine R Collins; Fiona Hackett; Maria Penzo; M Strath; Chrislaine Withers-Martinez; David A Baker; Michael J Blackman
Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress.
PLoS pathogens 2013;9(5):e1003344.
2013: Christine R Collins; Sujaan Das; Fiona Hackett; Jean-Paul Herman; Markus Meissner; Sylke Müller; Robert Stallmach; Eleanor H Wong; Nicole Andenmatten; Michael J Blackman
Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle.
Molecular microbiology 2013;88(4):687-701.
2013: Robert W Moon; Arnab Pain; Farania Rangkuti; Neil Almond; Joanna Hall; Yung Shwen Ho; Anthony A Holder; Graham H Mitchell; Michael J Blackman
Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(2):531-6.
2012: Andrea Ruecker; Michael Shea; Catherine Suarez; Chrislaine Withers-Martinez; Fiona Hackett; Elizabeth M A Hirst; Katarina Milutinovic; Michael J Blackman
Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte.
The Journal of biological chemistry 2012;287(45):37949-63.
2012: Chrislaine Withers-Martinez; Jean-Paul Ebejer; Paul Finn; Simone Fulle; Fiona Hackett; Aigars Jirgensons; Samir Kher; Kostas Koussis; Maria Penzo; Catherine Suarez; Michael J Blackman
Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target.
International journal for parasitology 2012;42(6):597-612.
2011: Natalie C Silmon de Monerri; Helen R Flynn; Marta G Campos; Fiona Hackett; Konstantinos Koussis; Chrislaine Withers-Martinez; J Mark Skehel; Michael J Blackman
Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease.
Infection and immunity 2011;79(3):1086-97.
2011: Joana M Santos; David J P Ferguson; Michael J Blackman; Dominique Soldati-Favre
Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode.
Science (New York, N.Y.) 2011;331(6016):473-7.
2009: Maria Lazarou; José A Guevara Patiño; Richard M Jennings; Richard S McIntosh; Jianguo Shi; Steven Howell; Eilish Cullen; Tarran Jones; Jaime R Adame-Gallegos; Jonathan A Chappel; Jana S McBride; Michael J Blackman; Anthony A Holder; Richard J Pleass
Inhibition of erythrocyte invasion and Plasmodium falciparum merozoite surface protein 1 processing by human immunoglobulin G1 (IgG1) and IgG3 antibodies.
Infection and immunity 2009;77(12):5659-67.
2009: Konstantinos Koussis; Chrislaine Withers-Martinez; Sharon Yeoh; Matthew Child; Fiona Hackett; Ellen Knuepfer; Luiz Juliano; Ute Woehlbier; Hermann Bujard; Michael J Blackman
A multifunctional serine protease primes the malaria parasite for red blood cell invasion.
The EMBO journal 2009;28(6):725-35.
2009: Christine R Collins; Chrislaine Withers-Martinez; Fiona Hackett; Michael J Blackman
An inhibitory antibody blocks interactions between components of the malarial invasion machinery.
PLoS pathogens 2009;5(1):e1000273.
2008: Kovilen Sawmynaden; Savvas Saouros; Nikolas Friedrich; Jan Marchant; Pete Simpson; Boris Bleijlevens; Michael J Blackman; Dominique Soldati-Favre; Stephen Matthews
Structural insights into microneme protein assembly reveal a new mode of EGF domain recognition.
EMBO reports 2008;9(11):1149-55.
2008: Michael J Blackman
Malarial proteases and host cell egress: an 'emerging' cascade.
Cellular microbiology 2008;10(10):1925-34.
2008: Chrislaine Withers-Martinez; Lesley F Haire; Fiona Hackett; Philip A Walker; Steven A Howell; Stephen John Smerdon; Guy G Dodson; Michael J Blackman
Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface.
Journal of molecular biology 2008;375(3):773-81.
2008: Timothy J Dowse; Konstantinos Koussis; Michael J Blackman; Dominique Soldati-Favre
Roles of proteases during invasion and egress by Plasmodium and Toxoplasma.
Sub-cellular biochemistry 2008;47():121-39.
2007: Sharon Yeoh; Rebecca A O'Donnell; Konstantinos Koussis; Anton R Dluzewski; Keith H Ansell; Simon A Osborne; Fiona Hackett; Chrislaine Withers-Martinez; Graham H Mitchell; Lawrence H Bannister; Justin S Bryans; Catherine A Kettleborough; Michael J Blackman
Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes.
Cell 2007;131(6):1072-83.
2007: Tharin M A Blumenschein; Nikolas Friedrich; Robert A Childs; Savvas Saouros; Elisabeth P Carpenter; María Asunción Campanero-Rhodes; Pete Simpson; Wengang Chai; Theodoros Koutroukides; Michael J Blackman; Ten Feizi; Dominique Soldati-Favre; Stephen Matthews
Atomic resolution insight into host cell recognition by Toxoplasma gondii.
The EMBO journal 2007;26(11):2808-20.
2007: Christine R Collins; Chrislaine Withers-Martinez; Graham A Bentley; Adrian H Batchelor; Alan Thomas; Michael J Blackman
Fine mapping of an epitope recognized by an invasion-inhibitory monoclonal antibody on the malaria vaccine candidate apical membrane antigen 1.
The Journal of biological chemistry 2007;282(10):7431-41.
2006: Rebecca A O'Donnell; Fiona Hackett; Steven A Howell; Moritz Treeck; Nicole Struck; Zita Krnajski; Chrislaine Withers-Martinez; Tim-Wolf Gilberger; Michael J Blackman
Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite.
The Journal of cell biology 2006;174(7):1023-33.
2005: Létitia Jean; Chrislaine Withers-Martinez; Fiona Hackett; Michael J Blackman
Unique insertions within Plasmodium falciparum subtilisin-like protease-1 are crucial for enzyme maturation and activity.
Molecular and biochemical parasitology 2005;144(2):187-97.
2005: Philippa K Harris; Sharon Yeoh; Anton R Dluzewski; Rebecca A O'Donnell; Chrislaine Withers-Martinez; Fiona Hackett; Lawrence H Bannister; Graham H Mitchell; Michael J Blackman
Molecular identification of a malaria merozoite surface sheddase.
PLoS pathogens 2005;1(3):241-51.
2005: Marie-Laure Chesne-seck; Juan Carlos Pizarro; Brigitte Vulliez-Le Normand; Christine R Collins; Michael J Blackman; Bart W Faber; Edmond J Remarque; Clemens H M Kocken; Alan Thomas; Graham A Bentley
Structural comparison of apical membrane antigen 1 orthologues and paralogues in apicomplexan parasites.
Molecular and biochemical parasitology 2005;144(1):55-67.
2005: Karolina Ersmark; Martin Nervall; Elizabeth Hamelink; Linda K Janka; José C Clemente; Ben M Dunn; Michael J Blackman; Bertil Samuelsson; Johan Aqvist; Anders Hallberg
Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations.
Journal of medicinal chemistry 2005;48(19):6090-106.
2005: Steven A Howell; Fiona Hackett; Artemio M Jongco; Chrislaine Withers-Martinez; Kami Kim; Vernon Bruce Carruthers; Michael J Blackman
Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens.
Molecular microbiology 2005;57(5):1342-56.
2005: Rebecca A O'Donnell; Michael J Blackman
The role of malaria merozoite proteases in red blood cell invasion.
Current opinion in microbiology 2005;8(4):422-7.
2005: Per-Ola Johansson; Jimmy Lindberg; Michael J Blackman; Ingemar Kvarnström; Lotta Vrang; Elizabeth Hamelink; Anders Hallberg; Asa Rosenquist; Bertil Samuelsson
Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II.
Journal of medicinal chemistry 2005;48(13):4400-9.
2005: Hannah E J Polson; Michael J Blackman
A role for poly(dA)poly(dT) tracts in directing activity of the Plasmodium falciparum calmodulin gene promoter.
Molecular and biochemical parasitology 2005;141(2):179-89.
2005: Juan Carlos Pizarro; Brigitte Vulliez-Le Normand; Marie-Laure Chesne-seck; Christine R Collins; Chrislaine Withers-Martinez; Fiona Hackett; Michael J Blackman; Bart W Faber; Edmond J Remarque; Clemens H M Kocken; Alan Thomas; Graham A Bentley
Crystal structure of the malaria vaccine candidate apical membrane antigen 1.
Science (New York, N.Y.) 2005;308(5720):408-11.
2005: Vernon Bruce Carruthers; Michael J Blackman
A new release on life: emerging concepts in proteolysis and parasite invasion.
Molecular microbiology 2005;55(6):1617-30.
2004: Michael J Blackman
Proteases in host cell invasion by the malaria parasite.
Cellular microbiology 2004;6(10):893-903.
2004: Chrislaine Withers-Martinez; Létitia Jean; Michael J Blackman
Subtilisin-like proteases of the malaria parasite.
Molecular microbiology 2004;53(1):55-63.
2004: Per-Ola Johansson; Yantao Chen; Anna Karin Belfrage; Michael J Blackman; Ingemar Kvarnström; Katarina Jansson; Lotta Vrang; Elizabeth Hamelink; Anders Hallberg; Asa Rosenquist; Bertil Samuelsson
Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs.
Journal of medicinal chemistry 2004;47(13):3353-66.
2004: Xing W Zhou; Michael J Blackman; Steven A Howell; Vernon Bruce Carruthers
Proteomic analysis of cleavage events reveals a dynamic two-step mechanism for proteolysis of a key parasite adhesive complex.
Molecular & cellular proteomics : MCP 2004;3(6):565-76.
2004: Olivier Silvie; Jean-François Franetich; Stéphanie Charrin; Markus S Mueller; Anthony Siau; Myriam Bodescot; Eric Rubinstein; Laurent Hannoun; Yupin Charoenvit; Clemens H M Kocken; Alan Thomas; Geert-Jan van Gemert; Robert W Sauerwein; Michael J Blackman; Robin F Anders; Gerd Pluschke; Dominique Mazier
A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites.
The Journal of biological chemistry 2004;279(10):9490-6.
2004: Karolina Ersmark; Isabella Feierberg; Sinisa Bjelic; Elizabeth Hamelink; Fiona Hackett; Michael J Blackman; Johan Hultén; Bertil Samuelsson; Johan Aqvist; Anders Hallberg
Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity.
Journal of medicinal chemistry 2004;47(1):110-22.
2003: Suzanne L Fleck; Berry Birdsall; jeffrey babon; Anton R Dluzewski; Stephen Martin; William D Morgan; Evelina Angov; Catherine A Kettleborough; James Feeney; Michael J Blackman; Anthony A Holder
Suramin and suramin analogues inhibit merozoite surface protein-1 secondary processing and erythrocyte invasion by the malaria parasite Plasmodium falciparum.
The Journal of biological chemistry 2003;278(48):47670-7.
2003: Lawrence H Bannister; John M Hopkins; Anton R Dluzewski; Gabriele Margos; Ian T Williams; Michael J Blackman; Clemens H M Kocken; Alan Thomas; Graham H Mitchell
Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite development.
Journal of cell science 2003;116(Pt 18):3825-34.
2003: Létitia Jean; Fiona Hackett; Stephen Martin; Michael J Blackman
Functional characterization of the propeptide of Plasmodium falciparum subtilisin-like protease-1.
The Journal of biological chemistry 2003;278(31):28572-9.
2003: Steven A Howell; Isabelle Well; Suzanne L Fleck; Catherine A Kettleborough; Christine R Collins; Michael J Blackman
A single malaria merozoite serine protease mediates shedding of multiple surface proteins by juxtamembrane cleavage.
The Journal of biological chemistry 2003;278(26):23890-8.
2002: Chrislaine Withers-Martinez; José W Saldanha; Barry Ely; Fiona Hackett; Tony O'Connor; Michael J Blackman
Expression of recombinant Plasmodium falciparum subtilisin-like protease-1 in insect cells. Characterization, comparison with the parasite protease, and homology modeling.
The Journal of biological chemistry 2002;277(33):29698-709.
2002: Clemens H M Kocken; Chrislaine Withers-Martinez; Martin A Dubbeld; Annemarie van der Wel; Fiona Hackett; Augusto Valderrama; Michael J Blackman; Alan Thomas
High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion.
Infection and immunity 2002;70(8):4471-6.
2001: S A Miller; E M Binder; Michael J Blackman; Vernon Bruce Carruthers; Kami Kim
A conserved subtilisin-like protein TgSUB1 in microneme organelles of Toxoplasma gondii.
The Journal of biological chemistry 2001;276(48):45341-8.
2001: Michael J Blackman; Lawrence H Bannister
Apical organelles of Apicomplexa: biology and isolation by subcellular fractionation.
Molecular and biochemical parasitology 2001;117(1):11-25.
2001: Steven A Howell; Chrislaine Withers-Martinez; Clemens H M Kocken; Alan Thomas; Michael J Blackman
Proteolytic processing and primary structure of Plasmodium falciparum apical membrane antigen-1.
The Journal of biological chemistry 2001;276(33):31311-20.
2000: Michael J Blackman
Proteases involved in erythrocyte invasion by the malaria parasite: function and potential as chemotherapeutic targets.
Current drug targets 2000;1(1):59-83.
2000: M Sajid; Chrislaine Withers-Martinez; Michael J Blackman
Maturation and specificity of Plasmodium falciparum subtilisin-like protease-1, a malaria merozoite subtilisin-like serine protease.
The Journal of biological chemistry 2000;275(1):631-41.
1999: Chrislaine Withers-Martinez; E P Carpenter; Fiona Hackett; B Ely; M Sajid; Munira Grainger; Michael J Blackman
PCR-based gene synthesis as an efficient approach for expression of the A+T-rich malaria genome.
Protein engineering 1999;12(12):1113-20.
1999: Fiona Hackett; M Sajid; Chrislaine Withers-Martinez; Munira Grainger; Michael J Blackman
PfSUB-2: a second subtilisin-like protein in Plasmodium falciparum merozoites.
Molecular and biochemical parasitology 1999;103(2):183-95.
1999: Anthony A Holder; Jose A. Guevara-Patino; Chairat Uthaipibull; Shabih-e-Hassnain Syed; Irene T Ling; Terry J Scott-Finnigan; Michael J Blackman
Merozoite surface protein 1, immune evasion, and vaccines against asexual blood stage malaria.
Parassitologia 1999;41(1-3):409-14.
1999: Michael J Blackman; Barbara Clough
Meeting report: Molecular Parasitology, Woods Hole, USA, September 13-17, 1998.
Protist 1999;150(1):3-6.
1998: Michael J Blackman; H Fujioka; W H Stafford; M Sajid; Barbara Clough; Suzanne L Fleck; M Aikawa; Munira Grainger; Fiona Hackett
A subtilisin-like protein in secretory organelles of Plasmodium falciparum merozoites.
The Journal of biological chemistry 1998;273(36):23398-409.
1998: L M Spencer Valero; Solabomi A Ogun; Suzanne L Fleck; Irene T Ling; Terry J Scott-Finnigan; Michael J Blackman; Anthony A Holder
Passive immunization with antibodies against three distinct epitopes on Plasmodium yoelii merozoite surface protein 1 suppresses parasitemia.
Infection and immunity 1998;66(8):3925-30.
1998: Michael J Blackman; P K Patnaik; Peter R Preiser
Meeting report: molecular parasitology, woods hole, USA 24-28 september, 1997.
Protist 1998;149(1):7-10.
1997: Jose A. Guevara-Patino; Anthony A Holder; Jana S McBride; Michael J Blackman
Antibodies that inhibit malaria merozoite surface protein-1 processing and erythrocyte invasion are blocked by naturally acquired human antibodies.
The Journal of experimental medicine 1997;186(10):1689-99.
1996: W H Stafford; B Günder; A Harris; H G Heidrich; Anthony A Holder; Michael J Blackman
A 22 kDa protein associated with the Plasmodium falciparum merozoite surface protein-1 complex.
Molecular and biochemical parasitology 1996;80(2):159-69.
1996: Michael J Blackman; E D Dennis; E M Hirst; Clemens H M Kocken; T J Scott-Finnigan; Alan Thomas
Plasmodium knowlesi: secondary processing of the malaria merozoite surface protein-1.
Experimental parasitology 1996;83(2):229-39.
1995: S Shai; Michael J Blackman; Anthony A Holder
Epitopes in the 19kDa fragment of the Plasmodium falciparum major merozoite surface protein-1 (PfMSP-1(19)) recognized by human antibodies.
Parasite immunology 1995;17(5):269-75.
1994: W H Stafford; Michael J Blackman; A Harris; S Shai; Munira Grainger; Anthony A Holder
N-terminal amino acid sequence of the Plasmodium falciparum merozoite surface protein-1 polypeptides.
Molecular and biochemical parasitology 1994;66(1):157-60.
1994: Michael J Blackman; T J Scott-Finnigan; S Shai; Anthony A Holder
Antibodies inhibit the protease-mediated processing of a malaria merozoite surface protein.
The Journal of experimental medicine 1994;180(1):389-93.
1994: Anthony A Holder; Michael J Blackman
What is the function of MSP-I on the malaria merozoite?
Parasitology today (Personal ed.) 1994;10(5):182-4.
1994: Anthony A Holder; Michael J Blackman; M Borre; P A Burghaus; J A Chappel; J K Keen; Irene T Ling; Solabomi A Ogun; C A Owen; KA Sinha
Malaria parasites and erythrocyte invasion.
Biochemical Society transactions 1994;22(2):291-5.
1994: Michael J Blackman
Purification of Plasmodium falciparum merozoites for analysis of the processing of merozoite surface protein-1.
Methods in cell biology 1994;45():213-20.
1993: Michael J Blackman; J A Chappel; S Shai; Anthony A Holder
A conserved parasite serine protease processes the Plasmodium falciparum merozoite surface protein-1.
Molecular and biochemical parasitology 1993;62(1):103-14.
1993: Michael J Blackman; Anthony A Holder
Use of a recombinant baculovirus product to measure naturally-acquired human antibodies to disulphide-constrained epitopes on the P. falciparum merozoite surface protein-1 (MSP1).
FEMS immunology and medical microbiology 1993;6(4):307-15.
1992: Michael J Blackman; Anthony A Holder
Secondary processing of the Plasmodium falciparum merozoite surface protein-1 (MSP1) by a calcium-dependent membrane-bound serine protease: shedding of MSP133 as a noncovalently associated complex with other fragments of the MSP1.
Molecular and biochemical parasitology 1992;50(2):307-15.
1992: Anthony A Holder; Michael J Blackman; P A Burghaus; J A Chappel; Irene T Ling; N McCallum-Deighton; S Shai
A malaria merozoite surface protein (MSP1)-structure, processing and function.
Memórias do Instituto Oswaldo Cruz 1992;87 Suppl 3():37-42.
1991: Michael J Blackman; Irene T Ling; S C Nicholls; Anthony A Holder
Proteolytic processing of the Plasmodium falciparum merozoite surface protein-1 produces a membrane-bound fragment containing two epidermal growth factor-like domains.
Molecular and biochemical parasitology 1991;49(1):29-33.
1991: Michael J Blackman; H Whittle; Anthony A Holder
Processing of the Plasmodium falciparum major merozoite surface protein-1: identification of a 33-kilodalton secondary processing product which is shed prior to erythrocyte invasion.
Molecular and biochemical parasitology 1991;49(1):35-44.
1990: Michael J Blackman; H G Heidrich; S Donachie; Jana S McBride; Anthony A Holder
A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies.
The Journal of experimental medicine 1990;172(1):379-82.