Paul Schimmel

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Sankaran Banumathi; Bonnett Shilah A; Shah Kinjal; Gabriel Scott; Reddy Robert; Schimmel Paul; Rodionov Dmitry A; de Crécy-Lagard Valérie; Helmann John D; Iwata-Reuyl Dirk; Swairjo Manal A
Zinc-independent folate biosynthesis: genetic, biochemical, and structural investigations reveal new metal dependence for GTP cyclohydrolase IB.
Guo Min; Chong Yeeting E; Beebe Kirk; Shapiro Ryan; Yang Xiang-Lei; Schimmel Paul
The C-Ala domain brings together editing and aminoacylation functions on one tRNA.
El Yacoubi Basma; Lyons Benjamin; Cruz Yulien; Reddy Robert; Nordin Brian; Agnelli Fabio; Williamson James R; Schimmel Paul; Swairjo Manal A; de Crécy-Lagard Valérie
The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA.

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2009: Sankaran Banumathi; Bonnett Shilah A; Shah Kinjal; Gabriel Scott; Reddy Robert; Schimmel Paul; Rodionov Dmitry A; de Crécy-Lagard Valérie; Helmann John D; Iwata-Reuyl Dirk; Swairjo Manal A
Zinc-independent folate biosynthesis: genetic, biochemical, and structural investigations reveal new metal dependence for GTP cyclohydrolase IB.
Journal of bacteriology 2009;191(22):6936-49.
2009: Guo Min; Chong Yeeting E; Beebe Kirk; Shapiro Ryan; Yang Xiang-Lei; Schimmel Paul
The C-Ala domain brings together editing and aminoacylation functions on one tRNA.
Science (New York, N.Y.) 2009;325(5941):744-7.
2009: El Yacoubi Basma; Lyons Benjamin; Cruz Yulien; Reddy Robert; Nordin Brian; Agnelli Fabio; Williamson James R; Schimmel Paul; Swairjo Manal A; de Crécy-Lagard Valérie
The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA.
Nucleic acids research 2009;37(9):2894-909.
2009: Schimmel Paul; Guo Min
A tipping point for mistranslation and disease.
Nature structural & molecular biology 2009;16(4):348-9.
2009: Schimmel Paul; Guo Min
Ancient tRNA synthetase meets modern structural biology.
Structure (London, England : 1993) 2009;17(3):315-7.
2008: Schimmel Paul
Development of tRNA synthetases and connection to genetic code and disease.
Protein science : a publication of the Protein Society 2008;17(10):1643-52.
2008: Cheng Gang; Zhang Hua; Yang Xianglei; Tzima Eleni; Ewalt Karla L; Schimmel Paul; Faber James E
Effect of mini-tyrosyl-tRNA synthetase on ischemic angiogenesis, leukocyte recruitment, and vascular permeability.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;295(4):R1138-46.
2008: Chong Yeeting E; Yang Xiang-Lei; Schimmel Paul
Natural homolog of tRNA synthetase editing domain rescues conditional lethality caused by mistranslation.
The Journal of biological chemistry 2008;283(44):30073-8.
2008: Schimmel Paul
An editing activity that prevents mistranslation and connection to disease.
The Journal of biological chemistry 2008;283(43):28777-82.
2008: Greenberg Y; King M; Kiosses W B; Ewalt K; Yang X; Schimmel P; Reader J S; Tzima E
The novel fragment of tyrosyl tRNA synthetase, mini-TyrRS, is secreted to induce an angiogenic response in endothelial cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(5):1597-605.
2008: Guo Min; Ignatov Michael; Musier-Forsyth Karin; Schimmel Paul; Yang Xiang-Lei
Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2331-6.
2008: Zhou Quansheng; Kiosses William B; Liu Jin; Schimmel Paul
Tumor endothelial cell tube formation model for determining anti-angiogenic activity of a tRNA synthetase cytokine.
Methods (San Diego, Calif.) 2008;44(2):190-5.
2008: Beebe Kirk; Mock Marissa; Merriman Eve; Schimmel Paul
Distinct domains of tRNA synthetase recognize the same base pair.
Nature 2008;451(7174):90-3.
2008: Kapoor Mili; Zhou Quansheng; Otero Francella; Myers Christopher A; Bates Alison; Belani Rajesh; Liu Jianming; Luo Jiann-Kae; Tzima Eleni; Zhang Dong-Er; Yang Xiang-Lei; Schimmel Paul
Evidence for annexin II-S100A10 complex and plasmin in mobilization of cytokine activity of human TrpRS.
The Journal of biological chemistry 2008;283(4):2070-7.
2007: Yang Xiang-Lei; Kapoor Mili; Otero Francella J; Slike Bonnie M; Tsuruta Hiro; Frausto Ricardo; Bates Alison; Ewalt Karla L; Cheresh David A; Schimmel Paul
Gain-of-function mutational activation of human tRNA synthetase procytokine.
Chemistry & biology 2007;14(12):1323-33.
2007: Waas William F; Schimmel Paul
Evidence that tRNA synthetase-directed proton transfer stops mistranslation.
Biochemistry 2007;46(43):12062-70.
2007: Waas William F; Druzina Zhanna; Hanan Melanie; Schimmel Paul
Role of a tRNA base modification and its precursors in frameshifting in eukaryotes.
The Journal of biological chemistry 2007;282(36):26026-34.
2007: Bacher Jamie M; Waas William F; Metzgar David; de Crécy-Lagard Valérie; Schimmel Paul
Genetic code ambiguity confers a selective advantage on Acinetobacter baylyi.
Journal of bacteriology 2007;189(17):6494-6.
2007: Beebe Kirk; Waas William; Druzina Zhanna; Guo Min; Schimmel Paul
A universal plate format for increased throughput of assays that monitor multiple aminoacyl transfer RNA synthetase activities.
Analytical biochemistry 2007;368(1):111-21.
2007: Yang Xiang-Lei; Guo Min; Kapoor Mili; Ewalt Karla L; Otero Francella J; Skene Robert J; McRee Duncan E; Schimmel Paul
Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase.
Structure (London, England : 1993) 2007;15(7):793-805.
2007: Nangle Leslie A; Zhang Wei; Xie Wei; Yang Xiang-Lei; Schimmel Paul
Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(27):11239-44.
2007: Xie Wei; Nangle Leslie A; Zhang Wei; Schimmel Paul; Yang Xiang-Lei
Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(24):9976-81.
2007: Bacher Jamie M; Schimmel Paul
An editing-defective aminoacyl-tRNA synthetase is mutagenic in aging bacteria via the SOS response.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(6):1907-12.
2006: Xie Wei; Schimmel Paul; Yang Xiang-Lei
Crystallization and preliminary X-ray analysis of a native human tRNA synthetase whose allelic variants are associated with Charcot-Marie-Tooth disease.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 12):1243-6.
2006: Nangle Leslie A; Motta Candace M; Schimmel Paul
Global effects of mistranslation from an editing defect in mammalian cells.
Chemistry & biology 2006;13(10):1091-100.
2006: Tamura Koji; Schimmel Paul R
Chiral-selective aminoacylation of an RNA minihelix: Mechanistic features and chiral suppression.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(37):13750-2.
2006: Yang Xiang-Lei; Otero Francella J; Ewalt Karla L; Liu Jianming; Swairjo Manal A; Köhrer Caroline; RajBhandary Uttam L; Skene Robert J; McRee Duncan E; Schimmel Paul
Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis.
The EMBO journal 2006;25(12):2919-29.
2006: Tzima Ellie; Schimmel Paul
Inhibition of tumor angiogenesis by a natural fragment of a tRNA synthetase.
Trends in biochemical sciences 2006;31(1):7-10.
2005: Waas William F; de Crécy-Lagard Valérie; Schimmel Paul
Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs.
The Journal of biological chemistry 2005;280(45):37616-22.
2005: Swairjo Manal A; Reddy Robert R; Lee Bobby; Van Lanen Steven G; Brown Shannon; de Crécy-Lagard Valérie; Iwata-Reuyl Dirk; Schimmel Paul
Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 10):945-8.
2005: Reader John S; Ordoukhanian Phillip T; Kim Jung-Gun; de Crécy-Lagard Valerie; Hwang Ingyu; Farrand Stephen; Schimmel Paul
Major biocontrol of plant tumors targets tRNA synthetase.
Science (New York, N.Y.) 2005;309(5740):1533.
2005: Ewalt Karla L; Yang Xiang-Lei; Otero Francella J; Liu Jianming; Slike Bonnie; Schimmel Paul
Variant of human enzyme sequesters reactive intermediate.
Biochemistry 2005;44(11):4216-21.
2005: Bacher Jamie M; de Crécy-Lagard Valérie; Schimmel Paul R
Inhibited cell growth and protein functional changes from an editing-defective tRNA synthetase.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1697-701.
2005: Swairjo Manal A; Schimmel Paul R
Breaking sieve for steric exclusion of a noncognate amino acid from active site of a tRNA synthetase.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(4):988-93.
2005: Tzima Eleni; Reader John S; Irani-Tehrani Mohamad; Ewalt Karla L; Schwartz Martin A; Schimmel Paul
VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function.
The Journal of biological chemistry 2005;280(4):2405-8.
2004: Schimmel Paul; Ewalt Karla
Translation silenced by fused pair of tRNA synthetases.
Cell 2004;119(2):147-8.
2004: Tamura Koji; Schimmel Paul
Chiral-selective aminoacylation of an RNA minihelix.
Science (New York, N.Y.) 2004;305(5688):1253.
2004: Pezo V; Metzgar D; Hendrickson T L; Waas W F; Hazebrouck S; Döring V; Marlière P; Schimmel P; De Crécy-Lagard V
Artificially ambiguous genetic code confers growth yield advantage.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(23):8593-7.
2004: Yang Xiang-Lei; Schimmel Paul; Ewalt Karla L
Relationship of two human tRNA synthetases used in cell signaling.
Trends in biochemical sciences 2004;29(5):250-6.
2004: Beebe Kirk; Merriman Eve; Ribas De Pouplana Lluis; Schimmel Paul
A domain for editing by an archaebacterial tRNA synthetase.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):5958-63.
2004: Lovato Martha A; Swairjo Manal A; Schimmel Paul
Positional recognition of a tRNA determinant dependent on a peptide insertion.
Molecular cell 2004;13(6):843-51.
2004: Swairjo Manal A; Otero Francella J; Yang Xiang-Lei; Lovato Martha A; Skene Robert J; McRee Duncan E; Ribas de Pouplana Lluis; Schimmel Paul
Alanyl-tRNA synthetase crystal structure and design for acceptor-stem recognition.
Molecular cell 2004;13(6):829-41.
2004: Reader John S; Metzgar David; Schimmel Paul; de Crécy-Lagard Valérie
Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine.
The Journal of biological chemistry 2004;279(8):6280-5.
2004: De Pereda Jose M; Waas William F; Jan Yiwen; Ruoslahti Erkki; Schimmel Paul; Pascual Jaime
Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity.
The Journal of biological chemistry 2004;279(9):8111-5.
2004: Tamura Koji; Schimmel Paul
Non-enzymatic aminoacylation of an RNA minihelix with an aminoacyl phosphate oligonucleotide.
Nucleic acids symposium series (2004) 2004;(48):269-70.
2004: Metzgar David; Bacher Jamie M; Pezo Valérie; Reader John; Döring Volker; Schimmel Paul; Marlière Philippe; de Crécy-Lagard Valérie
Acinetobacter sp. ADP1: an ideal model organism for genetic analysis and genome engineering.
Nucleic acids research 2004;32(19):5780-90.
2004: Hendrickson Tamara L; de Crécy-Lagard Valérie; Schimmel Paul
Incorporation of nonnatural amino acids into proteins.
Annual review of biochemistry 2004;73():147-76.
2004: Liu Jianming; Shue Eveline; Ewalt Karla L; Schimmel Paul
A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase.
Nucleic acids research 2004;32(2):719-27.
2003: Yang Xiang-Lei; Otero Francella J; Skene Robert J; McRee Duncan E; Schimmel Paul; Ribas de Pouplana Llúis
Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15376-80.
2003: Tzima E; Reader J S; Irani-Tehrani M; Ewalt K L; Schwartz M A; Schimmel P
Biologically active fragment of a human tRNA synthetase inhibits fluid shear stress-activated responses of endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):14903-7.
2003: Nordin Brian E; Schimmel Paul
Transiently misacylated tRNA is a primer for editing of misactivated adenylates by class I aminoacyl-tRNA synthetases.
Biochemistry 2003;42(44):12989-97.
2003: Beebe Kirk; Merriman Eve; Schimmel Paul
Structure-specific tRNA determinants for editing a mischarged amino acid.
The Journal of biological chemistry 2003;278(46):45056-61.
2003: Tamura Koji; Schimmel Paul
Peptide synthesis with a template-like RNA guide and aminoacyl phosphate adaptors.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8666-9.
2003: Schimmel Paul; Tamura Koji
tRNA structure goes from L to lambda.
Cell 2003;113(3):276-8.
2003: Beebe Kirk; Ribas De Pouplana Lluis; Schimmel Paul
Elucidation of tRNA-dependent editing by a class II tRNA synthetase and significance for cell viability.
The EMBO journal 2003;22(3):668-75.
2003: Bishop Anthony C; Beebe Kirk; Schimmel Paul R
Interstice mutations that block site-to-site translocation of a misactivated amino acid bound to a class I tRNA synthetase.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(2):490-4.
2002: Kushiro Tetsuo; Schimmel Paul
Trbp111 selectively binds a noncovalently assembled tRNA-like structure.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16631-5.
2002: Liu Jianming; Yang Xiang-Lei; Ewalt Karla L; Schimmel Paul
Mutational switching of a yeast tRNA synthetase into a mammalian-like synthetase cytokine.
Biochemistry 2002;41(48):14232-7.
2002: Yang Xiang-Lei; Skene Robert J; McRee Duncan E; Schimmel Paul
Crystal structure of a human aminoacyl-tRNA synthetase cytokine.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15369-74.
2002: Ewalt Karla L; Schimmel Paul
Activation of angiogenic signaling pathways by two human tRNA synthetases.
Biochemistry 2002;41(45):13344-9.
2002: Nangle Leslie A; De Crecy Lagard Valerie; Doring Volker; Schimmel Paul
Genetic code ambiguity. Cell viability related to the severity of editing defects in mutant tRNA synthetases.
The Journal of biological chemistry 2002;277(48):45729-33.
2002: Otani Atsushi; Kinder Karen; Ewalt Karla; Otero Francella J; Schimmel Paul; Friedlander Martin
Bone marrow-derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis.
Nature medicine 2002;8(9):1004-10.
2002: Bishop Anthony C; Xu Jimin; Johnson Reid C; Schimmel Paul; de Crécy-Lagard Valérie
Identification of the tRNA-dihydrouridine synthase family.
The Journal of biological chemistry 2002;277(28):25090-5.
2002: Wakasugi Keisuke; Slike Bonnie M; Hood John; Ewalt Karla L; Cheresh David A; Schimmel Paul
Induction of angiogenesis by a fragment of human tyrosyl-tRNA synthetase.
The Journal of biological chemistry 2002;277(23):20124-6.
2002: Nordin Brian E; Schimmel Paul
Plasticity of recognition of the 3'-end of mischarged tRNA by class I aminoacyl-tRNA synthetases.
The Journal of biological chemistry 2002;277(23):20510-7.
2002: Hendrickson Tamara L; Nomanbhoy Tyzoon K; de Crécy-Lagard Valérie; Fukai Shuya; Nureki Osamu; Yokoyama Shigeyuki; Schimmel Paul
Mutational separation of two pathways for editing by a class I tRNA synthetase.
Molecular cell 2002;9(2):353-62.
2002: Bishop Anthony C; Nomanbhoy Tyzoon K; Schimmel Paul
Blocking site-to-site translocation of a misactivated amino acid by mutation of a class I tRNA synthetase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):585-90.
2002: Wakasugi Keisuke; Slike Bonnie M; Hood John; Otani Atsushi; Ewalt Karla L; Friedlander Martin; Cheresh David A; Schimmel Paul
A human aminoacyl-tRNA synthetase as a regulator of angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):173-7.
2002: Otani Atsushi; Slike Bonnie M; Dorrell Michael I; Hood John; Kinder Karen; Ewalt Karla L; Cheresh David; Schimmel Paul; Friedlander Martin
A fragment of human TrpRS as a potent antagonist of ocular angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):178-83.
2001: Ribas de Pouplana L; Brown J R; Schimmel P
Structure-based phylogeny of class IIa tRNA synthetases in relation to an unusual biochemistry.
Journal of molecular evolution 2001;53(4-5):261-8.
2001: Ribas de Pouplana L; Schimmel P
Aminoacyl-tRNA synthetases: potential markers of genetic code development.
Trends in biochemical sciences 2001;26(10):591-6.
2001: Lovato M A; Chihade J W; Schimmel P
Translocation within the acceptor helix of a major tRNA identity determinant.
The EMBO journal 2001;20(17):4846-53.
2001: Nomanbhoy T K; Schimmel P
Active site of an aminoacyl-tRNA synthetase dissected by energy-transfer-dependent fluorescence.
Bioorganic & medicinal chemistry letters 2001;11(12):1485-91.
2001: Fàbrega C; Farrow M A; Mukhopadhyay B; de Crécy-Lagard V; Ortiz A R; Schimmel P
An aminoacyl tRNA synthetase whose sequence fits into neither of the two known classes.
Nature 2001;411(6833):110-4.
2001: Döring V; Mootz H D; Nangle L A; Hendrickson T L; de Crécy-Lagard V; Schimmel P; Marlière P
Enlarging the amino acid set of Escherichia coli by infiltration of the valine coding pathway.
Science (New York, N.Y.) 2001;292(5516):501-4.
2001: Farrow M A; Schimmel P
Editing by a tRNA synthetase: DNA aptamer-induced translocation and hydrolysis of a misactivated amino acid.
Biochemistry 2001;40(14):4478-83.
2001: Nomanbhoy T; Morales A J; Abraham A T; Vörtler C S; Giegé R; Schimmel P
Simultaneous binding of two proteins to opposite sides of a single transfer RNA.
Nature structural biology 2001;8(4):344-8.
2001: Kelley S O; Steinberg S V; Schimmel P
Fragile T-stem in disease-associated human mitochondrial tRNA sensitizes structure to local and distant mutations.
The Journal of biological chemistry 2001;276(14):10607-11.
2001: Ribas de Pouplana L; Schimmel P
Operational RNA code for amino acids in relation to genetic code in evolution.
The Journal of biological chemistry 2001;276(10):6881-4.
2001: Tamura K; Schimmel P
Oligonucleotide-directed peptide synthesis in a ribosome- and ribozyme-free system.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1393-7.
2001: Schimmel P; Ribas de Pouplana L
Formation of two classes of tRNA synthetases in relation to editing functions and genetic code.
Cold Spring Harbor symposia on quantitative biology 2001;66():161-6.
2000: Swairjo M A; Morales A J; Wang C C; Ortiz A R; Schimmel P
Crystal structure of trbp111: a structure-specific tRNA-binding protein.
The EMBO journal 2000;19(23):6287-98.
2000: Kelley S O; Steinberg S V; Schimmel P
Functional defects of pathogenic human mitochondrial tRNAs related to structural fragility.
Nature structural biology 2000;7(10):862-5.
2000: Turner R J; Lovato M; Schimmel P
One of two genes encoding glycyl-tRNA synthetase in Saccharomyces cerevisiae provides mitochondrial and cytoplasmic functions.
The Journal of biological chemistry 2000;275(36):27681-8.
2000: Hendrickson T L; Nomanbhoy T K; Schimmel P
Errors from selective disruption of the editing center in a tRNA synthetase.
Biochemistry 2000;39(28):8180-6.
2000: Ribas de Pouplana L; Schimmel P
A view into the origin of life: aminoacyl-tRNA synthetases.
Cellular and molecular life sciences : CMLS 2000;57(6):865-70.
2000: Wang C C; Morales A J; Schimmel P
Functional redundancy in the nonspecific RNA binding domain of a class I tRNA synthetase.
The Journal of biological chemistry 2000;275(22):17180-6.
2000: Nomanbhoy T K; Schimmel P R
Misactivated amino acids translocate at similar rates across surface of a tRNA synthetase.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5119-22.
2000: Schimmel P; Ribas De Pouplana L
Footprints of aminoacyl-tRNA synthetases are everywhere.
Trends in biochemical sciences 2000;25(5):207-9.
2000: Tamura K; Schimmel P
Trial for peptide bond formation using model molecules based on the interactions between the CCA sequence of tRNA and 23S rRNA.
Nucleic acids symposium series 2000;(44):251-2.
1999: Farrow M A; Nordin B E; Schimmel P
Nucleotide determinants for tRNA-dependent amino acid discrimination by a class I tRNA synthetase.
Biochemistry 1999;38(51):16898-903.
1999: Alexander R W; Schimmel P
Evidence for breaking domain-domain functional communication in a synthetase-tRNA complex.
Biochemistry 1999;38(49):16359-65.
1999: Steer B A; Schimmel P
Major anticodon-binding region missing from an archaebacterial tRNA synthetase.
The Journal of biological chemistry 1999;274(50):35601-6.
1999: Steer B A; Schimmel P
Domain-domain communication in a miniature archaebacterial tRNA synthetase.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(24):13644-9.
1999: Nomanbhoy T K; Hendrickson T L; Schimmel P
Transfer RNA-dependent translocation of misactivated amino acids to prevent errors in protein synthesis.
Molecular cell 1999;4(4):519-28.
1999: Chihade J W; Schimmel P
Assembly of a catalytic unit for RNA microhelix aminoacylation using nonspecific RNA binding domains.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12316-21.
1999: Sardesai N Y; Green R; Schimmel P
Efficient 50S ribosome-catalyzed peptide bond synthesis with an aminoacyl minihelix.
Biochemistry 1999;38(37):12080-8.
1999: Wakasugi K; Schimmel P
Highly differentiated motifs responsible for two cytokine activities of a split human tRNA synthetase.
The Journal of biological chemistry 1999;274(33):23155-9.
1999: Morales A J; Swairjo M A; Schimmel P
Structure-specific tRNA-binding protein from the extreme thermophile Aquifex aeolicus.
The EMBO journal 1999;18(12):3475-83.
1999: Wang C C; Schimmel P
Species barrier to RNA recognition overcome with nonspecific RNA binding domains.
The Journal of biological chemistry 1999;274(23):16508-12.
1999: Schimmel P; Wang C C
Getting tRNA synthetases into the nucleus.
Trends in biochemical sciences 1999;24(4):127-8.
1999: Steer B A; Schimmel P
Different adaptations of the same peptide motif for tRNA functional contacts by closely homologous tRNA synthetases.
Biochemistry 1999;38(16):4965-71.
1999: Wakasugi K; Schimmel P
Two distinct cytokines released from a human aminoacyl-tRNA synthetase.
Science (New York, N.Y.) 1999;284(5411):147-51.
1999: Nordin B E; Schimmel P
RNA determinants for translational editing. Mischarging a minihelix substrate by a tRNA synthetase.
The Journal of biological chemistry 1999;274(11):6835-8.
1999: Schimmel P; Ribas de Pouplana L
Genetic code origins: experiments confirm phylogenetic predictions and may explain a puzzle.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):327-8.
1998: Schimmel P; Tao J; Hill J
Aminoacyl tRNA synthetases as targets for new anti-infectives.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(15):1599-609.
1998: Alexander R W; Nordin B E; Schimmel P
Activation of microhelix charging by localized helix destabilization.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12214-9.
1998: Ribas de Pouplana L; Turner R J; Steer B A; Schimmel P
Genetic code origins: tRNAs older than their synthetases?
Proceedings of the National Academy of Sciences of the United States of America 1998;95(19):11295-300.
1998: Ribas de Pouplana L; Buechter D; Sardesai N Y; Schimmel P
Functional analysis of peptide motif for RNA microhelix binding suggests new family of RNA-binding domains.
The EMBO journal 1998;17(18):5449-57.
1998: Schimmel P; Alexander R
Diverse RNA substrates for aminoacylation: clues to origins?
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10351-3.
1998: Nureki O; Vassylyev D G; Tateno M; Shimada A; Nakama T; Fukai S; Konno M; Hendrickson T L; Schimmel P; Yokoyama S
Enzyme structure with two catalytic sites for double-sieve selection of substrate.
Science (New York, N.Y.) 1998;280(5363):578-82.

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