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Reinhard Schinzel

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Gholamreza Fazeli; Hanjoong Jo; Chih-Wen Ni; Reinhard Schinzel; Helga Stopper; Nicole Schupp
Angiotensin II induces DNA damage via AT1 receptor and NADPH oxidase isoform Nox4.
Nina Queisser; Reinhard Schinzel; Nicole Schupp; Helga Stopper; Patricia I Oteiza
Aldosterone increases kidney tubule cell oxidants through calcium-mediated activation of NADPH oxidase and nitric oxide synthase.
Joerg Geiger; Tobias Brandmann; Katharina Hubertus; Budy Tjahjadi; Reinhard Schinzel; Ulrich Walter
A protein phosphorylation-based assay for screening and monitoring of drugs modulating cyclic nucleotide pathways.

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2012: Gholamreza Fazeli; Hanjoong Jo; Chih-Wen Ni; Reinhard Schinzel; Helga Stopper; Nicole Schupp
Angiotensin II induces DNA damage via AT1 receptor and NADPH oxidase isoform Nox4.
Mutagenesis 2012;27(6):673-81.
2011: Nina Queisser; Reinhard Schinzel; Nicole Schupp; Helga Stopper; Patricia I Oteiza
Aldosterone increases kidney tubule cell oxidants through calcium-mediated activation of NADPH oxidase and nitric oxide synthase.
Free radical biology & medicine 2011;51(11):1996-2006.
2010: Joerg Geiger; Tobias Brandmann; Katharina Hubertus; Budy Tjahjadi; Reinhard Schinzel; Ulrich Walter
A protein phosphorylation-based assay for screening and monitoring of drugs modulating cyclic nucleotide pathways.
Analytical biochemistry 2010;407(2):261-9.
2005: Tibor K Vas; Zoltán Wagner; V Jenei; Zsuzsa Varga; Tibor Kovács; István Wittmann; Reinhard Schinzel; György Balla; József Balla; August Heidland; Judit Nagy
Oxidative stress and non-enzymatic glycation in IgA nephropathy.
Clinical nephrology 2005;64(5):343-51.
2005: Naila Ahmed; Reinhard Lüthen; Dieter Häussinger; Katarína Sebeková; Reinhard Schinzel; Wolfram Voelker; August Heidland; Paul J Thornalley
Increased protein glycation in cirrhosis and therapeutic strategies to prevent it.
Annals of the New York Academy of Sciences 2005;1043():718-24.
2005: Nicole Schupp; Reinhard Schinzel; August Heidland; Helga Stopper
Genotoxicity of advanced glycation end products: involvement of oxidative stress and of angiotensin II type 1 receptors.
Annals of the New York Academy of Sciences 2005;1043():685-95.
2005: Joerg Geiger; Lino Teichmann; Ralf Grossmann; Barsom Aktas; Udo Steigerwald; Ulrich Walter; Reinhard Schinzel
Monitoring of clopidogrel action: comparison of methods.
Clinical chemistry 2005;51(6):957-65.
2004: Naila Ahmed; Paul J Thornalley; Reinhard Lüthen; Dieter Häussinger; Katarina Sebekova; Reinhard Schinzel; Wolfram Voelker; August Heidland
Processing of protein glycation, oxidation and nitrosation adducts in the liver and the effect of cirrhosis.
Journal of hepatology 2004;41(6):913-9.
2004: August Heidland; Katarína Sebeková; Annamaria Frangiosa; Luca De Santo; M Cirillo; F Rossi; Maurizio Cotrufo; A Perna; André Klassen; Reinhard Schinzel; Natale G De Santo
Paradox of circulating advanced glycation end product concentrations in patients with congestive heart failure and after heart transplantation.
Heart (British Cardiac Society) 2004;90(11):1269-74.
2004: Björn Kuhla; Claudia Loske; S Garcia De Arriba; Reinhard Schinzel; J Huber; Gerald Münch
Differential effects of "Advanced glycation endproducts" and beta-amyloid peptide on glucose utilization and ATP levels in the neuronal cell line SH-SY5Y.
Journal of neural transmission (Vienna, Austria : 1996) 2004;111(3):427-39.
2003: Susana Garcia de Arriba; Claudia Loske; Ina Meiners; Gerd Fleischer; Michael Lobisch; Klaus Wessel; Hans Tritschler; Reinhard Schinzel; Gerald Münch
Advanced glycation endproducts induce changes in glucose consumption, lactate production, and ATP levels in SH-SY5Y neuroblastoma cells by a redox-sensitive mechanism.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(11):1307-13.
2003: Angela Galler; Grit Müller; Reinhard Schinzel; Jürgen Kratzsch; Wieland Kiess; Gerald Münch
Impact of metabolic control and serum lipids on the concentration of advanced glycation end products in the serum of children and adolescents with type 1 diabetes, as determined by fluorescence spectroscopy and nepsilon-(carboxymethyl)lysine ELISA.
Diabetes care 2003;26(9):2609-15.
2003: Katarína Sebeková; Marica Krajcovicová-Kudlácková; Pavol Blazícek; Vojtech Parrák; Reinhard Schinzel; August Heidland
Functional hyperhomocysteinemia in healthy vegetarians: no association with advanced glycation end products, markers of protein oxidation, or lipid peroxidation after correction with vitamin B(12).
Clinical chemistry 2003;49(6 Pt 1):983-6.
2003: Katarína Sebeková; Katarína Gazdíková; D Syrová; Pavol Blazícek; Reinhard Schinzel; August Heidland; Viera Spustová; R Dzúrik
Effects of ramipril in nondiabetic nephropathy: improved parameters of oxidatives stress and potential modulation of advanced glycation end products.
Journal of human hypertension 2003;17(4):265-70.
2003: Katarína Sebeková; Veronika Faist; Thomas Hofmann; Reinhard Schinzel; August Heidland
Effects of a diet rich in advanced glycation end products in the rat remnant kidney model.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2003;41(3 Suppl 1):S48-51.
2003: Helga Stopper; Reinhard Schinzel; Katarina Sebekova; August Heidland
Genotoxicity of advanced glycation end products in mammalian cells.
Cancer letters 2003;190(2):151-6.
2002: Sladjana Dukic-Stefanovic; Dorothee Schicktanz; Amanda Wong; Dieter Palm; Peter Riederer; Toshimitsu Niwa; Reinhard Schinzel; Gerald Münch
Characterization of antibody affinities using an AGE-modified dipeptide spot library.
Journal of immunological methods 2002;266(1-2):45-52.
2002: Susanne B Schwedler; Thomas Metzger; Reinhard Schinzel; Christoph Wanner
Advanced glycation end products and mortality in hemodialysis patients.
Kidney international 2002;62(1):301-10.
2002: Andrea Gerdemann; Zoltán Wagner; Andreas Solf; Udo Bahner; August Heidland; Joerg Hans Vienken; Reinhard Schinzel
Plasma levels of advanced glycation end products during haemodialysis, haemodiafiltration and haemofiltration: potential importance of dialysate quality.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2002;17(6):1045-9.
2002: Marica Krajcovicová-Kudlácková; Katarína Sebeková; Reinhard Schinzel; J Klvanová
Advanced glycation end products and nutrition.
Physiological research / Academia Scientiarum Bohemoslovaca 2002;51(3):313-6.
2002: Katarína Sebeková; Viera Kupcová; Reinhard Schinzel; August Heidland
Markedly elevated levels of plasma advanced glycation end products in patients with liver cirrhosis - amelioration by liver transplantation.
Journal of hepatology 2002;36(1):66-71.
2001: Katarína Sebeková; M Krajcoviová-Kudlácková; Reinhard Schinzel; V Faist; J Klvanová; August Heidland
Plasma levels of advanced glycation end products in healthy, long-term vegetarians and subjects on a western mixed diet.
European journal of nutrition 2001;40(6):275-81.
2001: Amanda Wong; Sladjana Dukic-Stefanovic; Jovana Gasic-Milenkovic; Reinhard Schinzel; H Wiesinger; Peter Riederer; Gerald Münch
Anti-inflammatory antioxidants attenuate the expression of inducible nitric oxide synthase mediated by advanced glycation endproducts in murine microglia.
The European journal of neuroscience 2001;14(12):1961-7.
2001: Katarína Sebeková; L Podracká; Pavol Blazícek; D Syrová; August Heidland; Reinhard Schinzel
Plasma levels of advanced glycation end products in children with renal disease.
Pediatric nephrology (Berlin, Germany) 2001;16(12):1105-12.
2001: Katarína Sebeková; L Podracká; August Heidland; Reinhard Schinzel
Enhanced plasma levels of advanced glycation end products (AGE) and pro-inflammatory cytokines in children/adolescents with chronic renal insufficiency and after renal replacement therapy by dialysis and transplantation--are they inter-related?
Clinical nephrology 2001;56(6):S21-6.
2001: Winnie Deuther-Conrad; Claudia Loske; Reinhard Schinzel; R Dringen; Peter Riederer; Gerald Münch
Advanced glycation endproducts change glutathione redox status in SH-SY5Y human neuroblastoma cells by a hydrogen peroxide dependent mechanism.
Neuroscience letters 2001;312(1):29-32.
2001: August Heidland; Katarina Sebekova; Reinhard Schinzel
Advanced glycation end products and the progressive course of renal disease.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2001;38(4 Suppl 1):S100-6.
2001: Zoltán Wagner; István Wittmann; István Mazák; Reinhard Schinzel; August Heidland; R Kientsch-Engel; Judit Nagy
N(epsilon)-(carboxymethyl)lysine levels in patients with type 2 diabetes: role of renal function.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2001;38(4):785-91.
2001: S Daoud; Reinhard Schinzel; A Neumann; Claudia Loske; D Fraccarollo; C Diez; Andreas Simm
Advanced glycation endproducts: activators of cardiac remodeling in primary fibroblasts from adult rat hearts.
Molecular medicine (Cambridge, Mass.) 2001;7(8):543-51.
2001: G Xiang; Reinhard Schinzel; Andreas Simm; Gerald Münch; Katarina Sebekova; M Kasper; Toshimitsu Niwa; C Schmitz; August Heidland
Advanced glycation end products (AGEs)-induced expression of TGF-beta 1 is suppressed by a protease in the tubule cell line LLC-PK1.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2001;16(8):1562-9.
2001: Peter Boor; Peter Bozek; Pavol Blazícek; D Syrová; Reinhard Schinzel; August Heidland; A Pecovová; Katarína Sebeková
[Increased levels of circulating advanced glycation end products in a model of acute renal insufficiency in rats].
Casopís lékar̆ů c̆eských 2001;140(12):375-80.
2001: Reinhard Schinzel; Gerald Münch; August Heidland; Katarina Sebekova
Advanced glycation end products in end-stage renal disease and their removal.
Nephron 2001;87(4):295-303.
2001: Katarína Sebeková; Pavol Blazícek; D Syrová; Z Krivosíková; Viera Spustová; August Heidland; Reinhard Schinzel
Circulating advanced glycation end product levels in rats rapidly increase with acute renal failure.
Kidney international. Supplement 2001;78():S58-62.
2001: G Xiang; Reinhard Schinzel; Andreas Simm; Katarina Sebekova; August Heidland
Advanced glycation end products impair protein turnover in LLC-PK1: amelioration by trypsin.
Kidney international. Supplement 2001;78():S53-7.
2001: Susanne B Schwedler; Reinhard Schinzel; P Vaith; Christoph Wanner
Inflammation and advanced glycation end products in uremia: simple coexistence, potentiation or causal relationship?
Kidney international. Supplement 2001;78():S32-6.
2001: Sladjana Dukic-Stefanovic; Reinhard Schinzel; Peter Riederer; Gerald Münch
AGES in brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs?
Biogerontology 2001;2(1):19-34.
2000: Andrea Gerdemann; Horst-Dieter Lemke; A Nothdurft; August Heidland; Gerald Münch; Udo Bahner; Reinhard Schinzel
Low-molecular but not high-molecular advanced glycation end products (AGEs) are removed by high-flux dialysis.
Clinical nephrology 2000;54(4):276-83.
2000: Katarína Sebeková; A Heidland; A Waidheim; Reinhard Schinzel
Evidence for accumulation of advanced glycation end products in acute renal failure.
Nephron 2000;86(2):186-7.
2000: Claudia Loske; Andrea Gerdemann; W Schepl; Matthias Wycislo; Reinhard Schinzel; Dieter Palm; Peter Riederer; Gerald Münch
Transition metal-mediated glycoxidation accelerates cross-linking of beta-amyloid peptide.
European journal of biochemistry / FEBS 2000;267(13):4171-8.
1999: Gerald Münch; D Schicktanz; A Behme; Manfred Gerlach; Peter Riederer; Dieter Palm; Reinhard Schinzel
Amino acid specificity of glycation and protein-AGE crosslinking reactivities determined with a dipeptide SPOT library.
Nature biotechnology 1999;17(10):1006-10.
1999: Katarína Sebeková; Reinhard Schinzel; Gerald Münch; Z Krivosíková; R Dzúrik; August Heidland
Advanced glycation end-product levels in subtotally nephrectomized rats: beneficial effects of angiotensin II receptor 1 antagonist losartan.
Mineral and electrolyte metabolism 1999;25(4-6):380-3.
1999: A Neumann; Reinhard Schinzel; Dieter Palm; Peter Riederer; Gerald Münch
High molecular weight hyaluronic acid inhibits advanced glycation endproduct-induced NF-kappaB activation and cytokine expression.
FEBS letters 1999;453(3):283-7.
1998: Katarína Sebeková; Reinhard Schinzel; H Ling; Andreas Simm; G Xiang; M Gekle; Gerald Münch; Spyros Vamvakas; August Heidland
Advanced glycated albumin impairs protein degradation in the kidney proximal tubules cell line LLC-PK1.
Cellular and molecular biology (Noisy-le-Grand, France) 1998;44(7):1051-60.
1998: Claudia Loske; A Neumann; A M Cunningham; K Nichol; Reinhard Schinzel; Peter Riederer; Gerald Münch
Cytotoxicity of advanced glycation endproducts is mediated by oxidative stress.
Journal of neural transmission (Vienna, Austria : 1996) 1998;105(8-9):1005-15.
1998: August Heidland; Reinhard Schinzel; Katarina Sebekova; G Xiang; Gerald Münch; Andreas Simm
Advanced glycation endproducts and the kidney.
Przegla̧d lekarski 1998;55 Suppl 1():29-31.
1998: Gerald Münch; Reinhard Schinzel; Claudia Loske; A Wong; Nuria Durany; J J Li; H Vlassara; Mark A. Smith; George Perry; Peter Riederer
Alzheimer's disease--synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts.
Journal of neural transmission (Vienna, Austria : 1996) 1998;105(4-5):439-61.
1997: Gerald Münch; R Keis; A Wessels; Peter Riederer; Udo Bahner; August Heidland; T Niwa; Horst-Dieter Lemke; Reinhard Schinzel
Determination of advanced glycation end products in serum by fluorescence spectroscopy and competitive ELISA.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1997;35(9):669-77.
1997: Andreas Simm; Gerald Münch; F Seif; O Schenk; August Heidland; H Richter; Spyros Vamvakas; Reinhard Schinzel
Advanced glycation endproducts stimulate the MAP-kinase pathway in tubulus cell line LLC-PK1.
FEBS letters 1997;410(2-3):481-4.
1997: Gerald Münch; S Mayer; J Michaelis; Alan R Hipkiss; Peter Riederer; R Müller; A Neumann; Reinhard Schinzel; A M Cunningham
Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of beta-amyloid peptide.
Biochimica et biophysica acta 1997;1360(1):17-29.
1997: Gerald Münch; Johannes Thome; P Foley; Reinhard Schinzel; Peter Riederer
Advanced glycation endproducts in ageing and Alzheimer's disease.
Brain research. Brain research reviews 1997;23(1-2):134-43.
1996: Johannes Thome; J Kornhuber; Gerald Münch; Reinhard Schinzel; Y Taneli; B Zielke; Michael Rösler; Peter Riederer
[New hypothesis on etiopathogenesis of Alzheimer syndrome. Advanced glycation end products (AGEs)].
Der Nervenarzt 1996;67(11):924-9.
1996: P Drueckes; Reinhard Schinzel
Activation of E350A mutant maltodextrin phosphorylase by exogenously added acetate.
Protein engineering 1996;9(8):701-5.
1996: B Boeck; Reinhard Schinzel
Purification and characterisation of an alpha-glucan phosphorylase from the thermophilic bacterium Thermus thermophilus.
European journal of biochemistry / FEBS 1996;239(1):150-5.
1996: P Drueckes; B Boeck; D Palm; Reinhard Schinzel
Mutational analysis of the oligosaccharide recognition site at the active site of Escherichia coli maltodextrin phosphorylase.
Biochemistry 1996;35(21):6727-34.
1996: Bernd Nidetzky; Andreas Weinhaeusel; Dietmar Haltrich; Klaus D Kulbe; Reinhard Schinzel
Maltodextrin phosphorylase from Escherichia coli: production and application for the synthesis of alpha-glucose-1-phosphate.
Annals of the New York Academy of Sciences 1996;782():208-18.
1996: Johannes Thome; Gerald Münch; R Müller; Reinhard Schinzel; J Kornhuber; D Blum-Degen; L Sitzmann; Michael Rösler; August Heidland; Peter Riederer
Advanced glycation endproducts-associated parameters in the peripheral blood of patients with Alzheimer's disease.
Life sciences 1996;59(8):679-85.
1995: P Drueckes; Reinhard Schinzel; D Palm
Photometric microtiter assay of inorganic phosphate in the presence of acid-labile organic phosphates.
Analytical biochemistry 1995;230(1):173-7.
1995: S Becker; Klaus D Schnackerz; Reinhard Schinzel
A study of binary complexes of Escherichia coli maltodextrin phosphorylase: alpha-D-glucose 1-methylenephosphonate as a probe of pyridoxal 5'-phosphate-substrate interactions.
Biochimica et biophysica acta 1995;1243(3):381-5.
1994: S Becker; D Palm; Reinhard Schinzel
Dissecting differential binding in the forward and reverse reaction of Escherichia coli maltodextrin phosphorylase using 2-deoxyglucosyl substrates.
The Journal of biological chemistry 1994;269(4):2485-90.
1994: Gerald Münch; Y Taneli; E Schraven; U Schindler; Reinhard Schinzel; D Palm; Peter Riederer
The cognition-enhancing drug tenilsetam is an inhibitor of protein crosslinking by advanced glycosylation.
Journal of neural transmission. Parkinson's disease and dementia section 1994;8(3):193-208.
1992: Reinhard Schinzel; D Palm; Klaus D Schnackerz
Pyridoxal 5'-phosphate as a 31P reporter observing functional changes in the active site of Escherichia coli maltodextrin phosphorylase after site-directed mutagenesis.
Biochemistry 1992;31(16):4128-33.
1991: Reinhard Schinzel; P Drueckes
The phosphate recognition site of Escherichia coli maltodextrin phosphorylase.
FEBS letters 1991;286(1-2):125-8.
1991: Reinhard Schinzel
Active site lysine promotes catalytic function of pyridoxal 5'-phosphate in alpha-glucan phosphorylases.
The Journal of biological chemistry 1991;266(15):9428-31.
1990: Reinhard Schinzel; D Palm
Escherichia coli maltodextrin phosphorylase: contribution of active site residues glutamate-637 and tyrosine-538 to the phosphorolytic cleavage of alpha-glucans.
Biochemistry 1990;29(42):9956-62.
1990: D Palm; H W Klein; Reinhard Schinzel; M Buehner; E J Helmreich
The role of pyridoxal 5'-phosphate in glycogen phosphorylase catalysis.
Biochemistry 1990;29(5):1099-107.

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