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Tilman Schirmer

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Jeremy M Zimbron; Didier Hamels; Tillmann Heinisch; Elisa S Nogueira; Tilman Schirmer; Maurus Schmid; Thomas R Ward
A dual anchoring strategy for the localization and activation of artificial metalloenzymes based on the biotin-streptavidin technology.
Philipp Engel; Arnaud Goepfert; Alexander Harms; Tilman Schirmer; Alexander Schmidt; Frédéric V Stanger; Christoph Dehio
Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins.
Aline S Borer; Donald R Hoffman; Tilman Schirmer; Margit Schmidt; Paul Wassmann; Christine Wright; Jing-Jiang Zhou; Zora Marković-Housley
Crystal structure of Sol I 2: a major allergen from fire ant venom.

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All Publications

2013: Jeremy M Zimbron; Didier Hamels; Tillmann Heinisch; Elisa S Nogueira; Tilman Schirmer; Maurus Schmid; Thomas R Ward
A dual anchoring strategy for the localization and activation of artificial metalloenzymes based on the biotin-streptavidin technology.
Journal of the American Chemical Society 2013;135(14):5384-8.
2012: Philipp Engel; Arnaud Goepfert; Alexander Harms; Tilman Schirmer; Alexander Schmidt; Frédéric V Stanger; Christoph Dehio
Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins.
Nature 2012;482(7383):107-10.
2012: Aline S Borer; Donald R Hoffman; Tilman Schirmer; Margit Schmidt; Paul Wassmann; Christine Wright; Jing-Jiang Zhou; Zora Marković-Housley
Crystal structure of Sol I 2: a major allergen from fire ant venom.
Journal of molecular biology 2012;415(4):635-48.
2012: Martin Gentner; Tilman Schirmer; Franziska Zaehringer; Martin G Allan; Stephan Grzesiek
Oligomer formation of the bacterial second messenger c-di-GMP: reaction rates and equilibrium constants indicate a monomeric state at physiological concentrations.
Journal of the American Chemical Society 2012;134(2):1019-29.
2011: Valentin Köhler; Jincheng Mao; Anca Pordea; Jean-Christophe Prost; Alessia Sardo; Tilman Schirmer; Marc Creus; Tillmann Heinisch; Livia Knörr; Yvonne M Wilson; Thomas R Ward
OsO4·streptavidin: a tunable hybrid catalyst for the enantioselective cis-dihydroxylation of olefins.
Angewandte Chemie (International ed. in English) 2011;50(46):10863-6.
2011: Sören Abel; Tania A Baker; Peter Chien; Volkhard Kaever; Michael T Laub; Tilman Schirmer; Paul Wassmann; Urs Jenal
Regulatory cohesion of cell cycle and cell differentiation through interlinked phosphorylation and second messenger networks.
Molecular cell 2011;43(4):550-60.
2011: Fabien W Monnard; Elisa S Nogueira; Tilman Schirmer; Tillmann Heinisch; Thomas R Ward
Human carbonic anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor.
Chemical communications (Cambridge, England) 2011;47(29):8238-40.
2011: Marc Dürrenberger; Tillmann Heinisch; Yvonne M Wilson; Thibaud Rossel; Elisa Nogueira; Livia Knörr; Annette Mutschler; Karoline Kersten; Malcolm Jeremy Zimbron; Julien Pierron; Tilman Schirmer; Thomas R Ward
Artificial transfer hydrogenases for the enantioselective reduction of cyclic imines.
Angewandte Chemie (International ed. in English) 2011;50(13):3026-9.
2011: Dinesh V Palanivelu; Arnaud Goepfert; Marcel Meury; Patrick Guye; Christoph Dehio; Tilman Schirmer
Fic domain-catalyzed adenylylation: insight provided by the structural analysis of the type IV secretion system effector BepA.
Protein science : a publication of the Protein Society 2011;20(3):492-9.
2011: Franziska Zähringer; Claudia Massa; Tilman Schirmer
Efficient enzymatic production of the bacterial second messenger c-di-GMP by the diguanylate cyclase YdeH from E. coli.
Applied biochemistry and biotechnology 2011;163(1):71-9.
2010: Jeremy M Zimbron; Alessia Sardo; Tillmann Heinisch; Therese Wohlschlager; Julieta Gradinaru; Claudia Massa; Tilman Schirmer; Marc Creus; Thomas R Ward
Chemo-genetic optimization of DNA recognition by metallodrugs using a presenter-protein strategy.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(43):12883-9.
2009: Christophe Wirth; Guy Condemine; Céline Boiteux; Simon Bernèche; Tilman Schirmer; Caroline M Peneff
NanC crystal structure, a model for outer-membrane channels of the acidic sugar-specific KdgM porin family.
Journal of molecular biology 2009;394(4):718-31.
2009: Zora Marković-Housley; Arnaud Basle; Sivaraman Padavattan; Bernhard Maderegger; Tilman Schirmer; Karin Hoffmann-Sommergruber
Structure of the major carrot allergen Dau c 1.
Acta crystallographica. Section D, Biological crystallography 2009;65(Pt 11):1206-12.
2009: Tilman Schirmer; Urs Jenal
Structural and mechanistic determinants of c-di-GMP signalling.
Nature reviews. Microbiology 2009;7(10):724-35.
2009: Alex Boehm; Samuel Steiner; Franziska Zaehringer; Alain Casanova; Fabienne Hamburger; Daniel Ritz; Wolfgang Keck; Martin Ackermann; Tilman Schirmer; Urs Jenal
Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress.
Molecular microbiology 2009;72(6):1500-16.
2009: Sivaraman Padavattan; Sabine Flicker; Tilman Schirmer; Christoph Madritsch; Stefanie Randow; Gerald Reese; Stefan Vieths; Christian Lupinek; Christof Ebner; Rudolf Valenta; Zora Markovic-Housley
High-affinity IgE recognition of a conformational epitope of the major respiratory allergen Phl p 2 as revealed by X-ray crystallography.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(4):2141-51.
2007: Paul Wassmann; Carmen Chan; Ralf Paul; Andreas Beck; Heiko Heerklotz; Urs Jenal; Tilman Schirmer
Structure of BeF3- -modified response regulator PleD: implications for diguanylate cyclase activation, catalysis, and feedback inhibition.
Structure (London, England : 1993) 2007;15(8):915-27.
2007: Sivaraman Padavattan; Tilman Schirmer; Margit Schmidt; Cezmi A. Akdis; Rudolf Valenta; Irene Mittermann; Lyudmilla Soldatova; Jay Slater; Ulrich Mueller; Zora Markovic-Housley
Identification of a B-cell epitope of hyaluronidase, a major bee venom allergen, from its crystal structure in complex with a specific Fab.
Journal of molecular biology 2007;368(3):742-52.
2006: Henk Miedema; Maarten Vrouenraets; Jenny Wierenga; Bob Eisenberg; Tilman Schirmer; Arnaud Baslé; Wim Meijberg
Conductance and selectivity fluctuations in D127 mutants of the bacterial porin OmpF.
European biophysics journal : EBJ 2006;36(1):13-22.
2006: Arnaud Baslé; Gabriele Rummel; Paola Storici; Jürg P Rosenbusch; Tilman Schirmer
Crystal structure of osmoporin OmpC from E. coli at 2.0 A.
Journal of molecular biology 2006;362(5):933-42.
2006: Dinesh V Palanivelu; David Kozono; Andreas Engel; Kitaru Suda; Ariel Lustig; Peter Agre; Tilman Schirmer
Co-axial association of recombinant eye lens aquaporin-0 observed in loosely packed 3D crystals.
Journal of molecular biology 2006;355(4):605-11.
2005: Michaela Markova; Caroline Peneff; Michael J E Hewlins; Tilman Schirmer; Robert A John
Determinants of substrate specificity in omega-aminotransferases.
The Journal of biological chemistry 2005;280(43):36409-16.
2005: Tilman Schirmer; Karin Hoffimann-Sommergrube; Markus Susani; Heimo Breiteneder; Zora Marković-Housley
Crystal structure of the major celery allergen Api g 1: molecular analysis of cross-reactivity.
Journal of molecular biology 2005;351(5):1101-9.
2005: Kwok-Min Hui; George L Orriss; Tilman Schirmer; Bergljot Magnadottir; Jürg A Schifferli; Jameel M Inal
Expression of functional recombinant von Willebrand factor-A domain from human complement C2: a potential binding site for C4 and CRIT.
The Biochemical journal 2005;389(Pt 3):863-8.
2005: Ansgar Philippsen; Tilman Schirmer; Martin A Stein; Friedrich Giffhorn; Jörg Stetefeld
Structure of zinc-independent sorbitol dehydrogenase from Rhodobacter sphaeroides at 2.4 A resolution.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 4):374-9.
2004: Carmen Chan; Ralf Paul; Dietrich Samoray; Nicolas C Amiot; Bernd Giese; Urs Jenal; Tilman Schirmer
Structural basis of activity and allosteric control of diguanylate cyclase.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(49):17084-9.
2004: Paola Storici; Jian Qiu; Tilman Schirmer; Richard B Silverman
Mechanistic crystallography. Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid as elucidated by crystallography.
Biochemistry 2004;43(44):14057-63.
2004: Ralf Paul; Stefan Weiser; Nicholas C Amiot; Carmen Chan; Tilman Schirmer; Bernd Giese; Urs Jenal
Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain.
Genes & development 2004;18(6):715-27.
2004: Paola Storici; Daniela De Biase; Francesco Bossa; Stefano Bruno; Andrea Mozzarelli; Caroline Peneff; Richard B Silverman; Tilman Schirmer
Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin.
The Journal of biological chemistry 2004;279(1):363-73.
2003: George L Orriss; Bernhard Erni; Tilman Schirmer
Crystal structure of the IIB(Sor) domain of the sorbose permease from Klebsiella pneumoniae solved to 1.75A resolution.
Journal of molecular biology 2003;327(5):1111-9.
2002: Raimund Dutzler; Tilman Schirmer; Martin Karplus; Stefan Fischer
Translocation mechanism of long sugar chains across the maltoporin membrane channel.
Structure (London, England : 1993) 2002;10(9):1273-84.
2002: Patrick Van Gelder; Fabrice Dumas; Ingrid Bartoldus; Nathalie Saint; Alexei Prilipov; Mathias Winterhalter; Yanfei Wang; Ansgar Philippsen; Jürg P Rosenbusch; Tilman Schirmer
Sugar transport through maltoporin of Escherichia coli: role of the greasy slide.
Journal of bacteriology 2002;184(11):2994-9.
2002: Ansgar Philippsen; Wonpil Im; Andreas Engel; Tilman Schirmer; Benoît Roux; Daniel J Müller
Imaging the electrostatic potential of transmembrane channels: atomic probe microscopy of OmpF porin.
Biophysical journal 2002;82(3):1667-76.
2002: Sun Choi; Paola Storici; Tilman Schirmer; Richard B Silverman
Design of a conformationally restricted analogue of the antiepilepsy drug Vigabatrin that directs its mechanism of inactivation of gamma-aminobutyric acid aminotransferase.
Journal of the American Chemical Society 2002;124(8):1620-4.
2002: Oliver Sauer; Michel Roth; Tilman Schirmer; Gabriele Rummel; Christoph Kratky
Low-resolution detergent tracing in protein crystals using xenon or krypton to enhance X-ray contrast.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 1):60-9.
2001: Patrick Van Gelder; Raimund Dutzler; Fabrice Dumas; Ralf Koebnik; Tilman Schirmer
Sucrose transport through maltoporin mutants of Escherichia coli.
Protein engineering 2001;14(11):943-8.
2001: PS Phale; Ansgar Philippsen; C Widmer; V P Phale; Jürg P Rosenbusch; Tilman Schirmer
Role of charged residues at the OmpF porin channel constriction probed by mutagenesis and simulation.
Biochemistry 2001;40(21):6319-25.
2000: Z Marković-Housley; G Miglierini; Lyudmilla Soldatova; P J Rizkallah; Ulrich Müller; Tilman Schirmer
Crystal structure of hyaluronidase, a major allergen of bee venom.
Structure (London, England : 1993) 2000;8(10):1025-35.
1999: Tilman Schirmer; PS Phale
Brownian dynamics simulation of ion flow through porin channels.
Journal of molecular biology 1999;294(5):1159-67.
1999: Paola Storici; Guido Capitani; Daniela De Biase; M Moser; Robert A John; Johan N Jansonius; Tilman Schirmer
Crystal structure of GABA-aminotransferase, a target for antiepileptic drug therapy.
Biochemistry 1999;38(27):8628-34.
1999: Raimund Dutzler; Gabriele Rummel; Sebastián Albertí; Santiago Hernández-Allés; PS Phale; Jürg P Rosenbusch; Vicente Javier Benedí; Tilman Schirmer
Crystal structure and functional characterization of OmpK36, the osmoporin of Klebsiella pneumoniae.
Structure (London, England : 1993) 1999;7(4):425-34.
1999: Paola Storici; Guido Capitani; R Müller; Tilman Schirmer; Johan N Jansonius
Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine.
Journal of molecular biology 1999;285(1):297-309.
1998: PS Phale; Ansgar Philippsen; Thomas Kiefhaber; Ralf Koebnik; V P Phale; Tilman Schirmer; Jürg P Rosenbusch
Stability of trimeric OmpF porin: the contributions of the latching loop L2.
Biochemistry 1998;37(45):15663-70.
1998: S Penel; Eva Pebay-Peyroula; Jürg P Rosenbusch; Gabriele Rummel; Tilman Schirmer; P A Timmins
Detergent binding in trigonal crystals of OmpF porin from Escherichia coli.
Biochimie 1998;80(5-6):543-51.
1998: B W Shen; Michael Hennig; E Hohenester; Johan N Jansonius; Tilman Schirmer
Crystal structure of human recombinant ornithine aminotransferase.
Journal of molecular biology 1998;277(1):81-102.
1998: S Schauder; R S Nunn; Roland Lanz; Bernhard Erni; Tilman Schirmer
Crystal structure of the IIB subunit of a fructose permease (IIBLev) from Bacillus subtilis.
Journal of molecular biology 1998;276(3):591-602.
1998: Tilman Schirmer
General and specific porins from bacterial outer membranes.
Journal of structural biology 1998;121(2):101-9.
1997: Y F Wang; Raimund Dutzler; P J Rizkallah; Jürg P Rosenbusch; Tilman Schirmer
Channel specificity: structural basis for sugar discrimination and differential flux rates in maltoporin.
Journal of molecular biology 1997;272(1):56-63.
1997: PS Phale; Tilman Schirmer; Alexei Prilipov; K L Lou; A Hardmeyer; Jürg P Rosenbusch
Voltage gating of Escherichia coli porin channels: role of the constriction loop.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6741-5.
1997: M Watanabe; Jürg P Rosenbusch; Tilman Schirmer; Martin Karplus
Computer simulations of the OmpF porin from the outer membrane of Escherichia coli.
Biophysical journal 1997;72(5):2094-102.
1996: Nathalie Saint; K L Lou; C Widmer; M Luckey; Tilman Schirmer; Jürg P Rosenbusch
Structural and functional characterization of OmpF porin mutants selected for larger pore size. II. Functional characterization.
The Journal of biological chemistry 1996;271(34):20676-80.
1996: K L Lou; Nathalie Saint; Alexei Prilipov; Gabriele Rummel; S A Benson; Jürg P Rosenbusch; Tilman Schirmer
Structural and functional characterization of OmpF porin mutants selected for larger pore size. I. Crystallographic analysis.
The Journal of biological chemistry 1996;271(34):20669-75.
1996: R S Nunn; Z Marković-Housley; J C Génovésio-Taverne; Karin Flükiger; P J Rizkallah; Johan N Jansonius; Tilman Schirmer; Bernhard Erni
Structure of the IIA domain of the mannose transporter from Escherichia coli at 1.7 angstroms resolution.
Journal of molecular biology 1996;259(3):502-11.
1996: Nathalie Saint; Alexei Prilipov; A Hardmeyer; K L Lou; Tilman Schirmer; Jürg P Rosenbusch
Replacement of the sole histidinyl residue in OmpF porin from E. coli by threonine (H21T) does not affect channel structure and function.
Biochemical and biophysical research communications 1996;223(1):118-22.
1996: Z Marković-Housley; Tilman Schirmer; E Hohenester; A R Khomutov; R M Khomutov; M Y Karpeisky; Erika Sandmeier; Philipp Christen; Johan N Jansonius
Crystal structures and solution studies of oxime adducts of mitochondrial aspartate aminotransferase.
European journal of biochemistry / FEBS 1996;236(3):1025-32.
1996: Raimund Dutzler; Y F Wang; P Rizkallah; Jürg P Rosenbusch; Tilman Schirmer
Crystal structures of various maltooligosaccharides bound to maltoporin reveal a specific sugar translocation pathway.
Structure (London, England : 1993) 1996;4(2):127-34.
1995: Sebastián Albertí; F Rodríquez-Quiñones; Tilman Schirmer; Gabriele Rummel; Juan M Tomás; Jürg P Rosenbusch; Vicente Javier Benedí
A porin from Klebsiella pneumoniae: sequence homology, three-dimensional model, and complement binding.
Infection and immunity 1995;63(3):903-10.
1995: Tilman Schirmer; T A Keller; Y F Wang; Jürg P Rosenbusch
Structural basis for sugar translocation through maltoporin channels at 3.1 A resolution.
Science (New York, N.Y.) 1995;267(5197):512-4.
1994: Denis Jeanteur; Tilman Schirmer; D Fourel; V Simonet; Gabriele Rummel; C Widmer; Jürg P Rosenbusch; Franc Pattus; Jean-Marie Pagès
Structural and functional alterations of a colicin-resistant mutant of OmpF porin from Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10675-9.
1994: Andrey Karshikoff; Velin Spassov; S W Cowan; Rudolf Ladenstein; Tilman Schirmer
Electrostatic properties of two porin channels from Escherichia coli.
Journal of molecular biology 1994;240(4):372-84.
1993: Tilman Schirmer; S W Cowan
Prediction of membrane-spanning beta-strands and its application to maltoporin.
Protein science : a publication of the Protein Society 1993;2(8):1361-3.
1993: G Pflügl; J Kallen; Tilman Schirmer; Johan N Jansonius; M G Zurini; Malcolm D Walkinshaw
X-ray structure of a decameric cyclophilin-cyclosporin crystal complex.
Nature 1993;361(6407):91-4.
1992: S W Cowan; Tilman Schirmer; Gabriele Rummel; Matthias Steiert; R Ghosh; Richard A Pauptit; Johan N Jansonius; Jürg P Rosenbusch
Crystal structures explain functional properties of two E. coli porins.
Nature 1992;358(6389):727-33.
1991: Richard A Pauptit; Tilman Schirmer; Johan N Jansonius; Jürg P Rosenbusch; Michael W Parker; A D Tucker; Demetrius Tsernoglou; M S Weiss; G E Schultz
A common channel-forming motif in evolutionarily distant porins.
Journal of structural biology 1991;107(2):136-45.
1991: Richard A Pauptit; H Zhang; Gabriele Rummel; Tilman Schirmer; Johan N Jansonius; Jürg P Rosenbusch
Trigonal crystals of porin from Escherichia coli.
Journal of molecular biology 1991;218(3):505-7.
1990: Z Marković-Housley; Tilman Schirmer; B Fol; Johan N Jansonius; Daniela De Biase; Robert A John
Crystallization and preliminary X-ray analysis of gamma-aminobutyric acid transaminase.
Journal of molecular biology 1990;214(4):821-3.