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Birgit Schittek

Research Profile

Disorders

Chemicals & Drugs

Procedures

Reverse Transcriptase Polymerase Chain Reaction

Anatomy

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Publications

TOP 3
Chonglin Luo; Patrick R Merz; Dirk Schadendorf; Birgit Schittek; Tobias Sinnberg; Paul W Tetteh; Alia Abukiwan; Elke Dickes; Sven Diederichs; Stefan Holland-Cunz; Agnes Hotz-Wagenblatt; Stefan B Eichmüller
miR-137 inhibits the invasion of melanoma cells through downregulation of multiple oncogenic target genes.
Ines Wanke; Yuliya Skabytska; Tilo Biedermann; Beatrice Kraft; Andreas Peschel; Birgit Schittek
Staphylococcus aureus skin colonization is promoted by barrier disruption and leads to local inflammation.
Daniela Beck; Tilo Biedermann; Christian Busch; Stefan Drießen; Jürgen Eberle; Keith Flaherty; Claus Garbe; Juan Lucio Iovanna; Dagmar Kulms; Konstantinos G Lasithiotakis; Heike Niessner; Kim H T Paraiso; Dirk Schadendorf; Martin Schaller; Birgit Schittek; Tobias Sinnberg; Keiran S M Smalley; Björn Stork; Sophie Vasseur; Benjamin Weide; Sebastian Wesselborg; Jürgen Bauer; Friedegund Meier
Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells.

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All Publications

2013: Chonglin Luo; Patrick R Merz; Dirk Schadendorf; Birgit Schittek; Tobias Sinnberg; Paul W Tetteh; Alia Abukiwan; Elke Dickes; Sven Diederichs; Stefan Holland-Cunz; Agnes Hotz-Wagenblatt; Stefan B Eichmüller
miR-137 inhibits the invasion of melanoma cells through downregulation of multiple oncogenic target genes.
The Journal of investigative dermatology 2013;133(3):768-75.
2013: Ines Wanke; Yuliya Skabytska; Tilo Biedermann; Beatrice Kraft; Andreas Peschel; Birgit Schittek
Staphylococcus aureus skin colonization is promoted by barrier disruption and leads to local inflammation.
Experimental dermatology 2013;22(2):153-5.
2013: Daniela Beck; Tilo Biedermann; Christian Busch; Stefan Drießen; Jürgen Eberle; Keith Flaherty; Claus Garbe; Juan Lucio Iovanna; Dagmar Kulms; Konstantinos G Lasithiotakis; Heike Niessner; Kim H T Paraiso; Dirk Schadendorf; Martin Schaller; Birgit Schittek; Tobias Sinnberg; Keiran S M Smalley; Björn Stork; Sophie Vasseur; Benjamin Weide; Sebastian Wesselborg; Jürgen Bauer; Friedegund Meier
Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells.
Science signaling 2013;6(260):ra7.
2012: Barbara Spangler; Lily Vardimon; Anja Katrin Bosserhoff; Melanie Kappelmann; Svenja Meierjohann; Birgit Schittek; Silke Kuphal
ETS-1/RhoC signaling regulates the transcription factor c-Jun in melanoma.
International journal of cancer. Journal international du cancer 2012;130(12):2801-11.
2012: Tobias Sinnberg; Barbara Spangler; Anja Bosserhoff; Per Holm; Silke Kuphal; Birgit Sauer; Birgit Schittek
MAPK and PI3K/AKT mediated YB-1 activation promotes melanoma cell proliferation which is counteracted by an autoregulatory loop.
Experimental dermatology 2012;21(4):265-70.
2012: Maren Paulmann; Thomas Arnold; Jochen Bürck; Thomas Gutsmann; Michael Habeck; Hubert Kalbacher; Annika Kopp; Dirk Linke; Verena J Schuenemann; Anne S Ulrich; Ines Wanke; Suat Ozdirekcan; Birgit Schittek
Structure-activity analysis of the dermcidin-derived peptide DCD-1L, an anionic antimicrobial peptide present in human sweat.
The Journal of biological chemistry 2012;287(11):8434-43.
2012: Birgit Schittek
The multiple facets of dermcidin in cell survival and host defense.
Journal of innate immunity 2012;4(4):349-60.
2011: Ines Wanke; Heiko Steffen; Christina Christ; Bernhard Krismer; Friedrich Götz; Andreas Peschel; Martin Schaller; Birgit Schittek
Skin commensals amplify the innate immune response to pathogens by activation of distinct signaling pathways.
The Journal of investigative dermatology 2011;131(2):382-90.
2011: Heike Niessner; Daniela Beck; Tobias Sinnberg; Konstantinos G Lasithiotakis; Evelyn Maczey; Jeannette Gogel; Sascha Venturelli; Alexander Berger; Mario Mauthe; Mahmoud Toulany; Keith Flaherty; Martin Schaller; Dirk Schadendorf; Tassula Proikas-Cezanne; Birgit Schittek; Claus Garbe; Dagmar Kulms; Friedegund Meier
The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells.
The Journal of investigative dermatology 2011;131(2):468-79.
2011: Tobias Sinnberg; Michael Schwarz; Daniel Ewerth; Claus Garbe; Moritz Menzel; Birgit Sauer; Martin Schaller; Birgit Schittek
β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance.
PloS one 2011;6(8):e23429.
2011: Birgit Schittek
The antimicrobial skin barrier in patients with atopic dermatitis.
Current problems in dermatology 2011;41():54-67.
2010: Tobias Sinnberg; Moritz Menzel; Susanne Kaesler; Tilo Biedermann; Birgit Sauer; Sven Nahnsen; Michael Schwarz; Claus Garbe; Birgit Schittek
Suppression of casein kinase 1alpha in melanoma cells induces a switch in beta-catenin signaling to promote metastasis.
Cancer research 2010;70(17):6999-7009.
2010: Ilknur Senyürek; Gerd Klein; Hubert Kalbacher; Martin Deeg; Birgit Schittek
Peptides derived from the human laminin alpha4 and alpha5 chains exhibit antimicrobial activity.
Peptides 2010;31(8):1468-72.
2010: Philipp Zanger; Johannes Holzer; Regina Schleucher; Helmut Scherbaum; Birgit Schittek; Sabine Gabrysch
Severity of Staphylococcus aureus infection of the skin is associated with inducibility of human beta-defensin 3 but not human beta-defensin 2.
Infection and immunity 2010;78(7):3112-7.
2010: Jessica Spreu; Sabrina Kuttruff; Veronika Stejfova; Kevin M Dennehy; Birgit Schittek; Alexander Steinle
Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(11):5100-5.
2009: Philipp Zanger; Johannes Holzer; Regina Schleucher; Heiko Steffen; Birgit Schittek; Sabine Gabrysch
Constitutive expression of the antimicrobial peptide RNase 7 is associated with Staphylococcus aureus infection of the skin.
The Journal of infectious diseases 2009;200(12):1907-15.
2009: Min Li; Kevin Rigby; Yuping Lai; Vinod Nair; Andreas Peschel; Birgit Schittek; Michael Otto
Staphylococcus aureus mutant screen reveals interaction of the human antimicrobial peptide dermcidin with membrane phospholipids.
Antimicrobial agents and chemotherapy 2009;53(10):4200-10.
2009: I Senyürek; Gerd Döring; Hubert Kalbacher; Martin Deeg; Andreas Peschel; Christiane Wolz; Birgit Schittek
Resistance to dermcidin-derived peptides is independent of bacterial protease activity.
International journal of antimicrobial agents 2009;34(1):86-90.
2009: Ilknur Senyürek; Maren Paulmann; Tobias Sinnberg; Hubert Kalbacher; Martin Deeg; Thomas Gutsmann; Marina Hermes; Thomas Kohler; Friedrich Götz; Christiane Wolz; Andreas Peschel; Birgit Schittek
Dermcidin-derived peptides show a different mode of action than the cathelicidin LL-37 against Staphylococcus aureus.
Antimicrobial agents and chemotherapy 2009;53(6):2499-509.
2009: Tobias Sinnberg; Konstantinos G Lasithiotakis; Heike Niessner; Birgit Schittek; Keith T Flaherty; Dagmar Kulms; Evelyn Maczey; Minia Campos; Jeannette Gogel; Claus Garbe; Friedegund Meier
Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide.
The Journal of investigative dermatology 2009;129(6):1500-15.
2008: Birgit Schittek; Maren Paulmann; Ilknur Senyürek; Heiko Steffen
The role of antimicrobial peptides in human skin and in skin infectious diseases.
Infectious disorders drug targets 2008;8(3):135-43.
2008: Konstantinos G Lasithiotakis; Tobias W Sinnberg; Birgit Schittek; Keith T Flaherty; Dagmar Kulms; Evelyn Maczey; Claus Garbe; Friedegund Meier
Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells.
The Journal of investigative dermatology 2008;128(8):2013-23.
2007: Friedegund Meier; S Busch; Konstantinos G Lasithiotakis; D Kulms; Claus Garbe; Evelyn Maczey; Meenhard Herlyn; Birgit Schittek
Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment.
The British journal of dermatology 2007;156(6):1204-13.
2007: Birgit Schittek; Karin Psenner; Birgit Sauer; Friedegund Meier; Thomas Iftner; Claus Garbe
The increased expression of Y box-binding protein 1 in melanoma stimulates proliferation and tumor invasion, antagonizes apoptosis and enhances chemoresistance.
International journal of cancer. Journal international du cancer 2007;120(10):2110-8.
2006: Heiko Steffen; Siegbert Rieg; Imke Wiedemann; Hubert Kalbacher; Martin Deeg; Hans-Georg Sahl; Andreas Peschel; Friedrich Götz; Claus Garbe; Birgit Schittek
Naturally processed dermcidin-derived peptides do not permeabilize bacterial membranes and kill microorganisms irrespective of their charge.
Antimicrobial agents and chemotherapy 2006;50(8):2608-20.
2006: Friedegund Meier; Silke Busch; Daniela Gast; Anne Göppert; Peter Altevogt; Evelyn Maczey; Svenja Riedle; Claus Garbe; Birgit Schittek
The adhesion molecule L1 (CD171) promotes melanoma progression.
International journal of cancer. Journal international du cancer 2006;119(3):549-55.
2006: Daniel Baechle; Thomas Flad; Alexander Cansier; Heiko Steffen; Birgit Schittek; Jonathan Tolson; Timo Herrmann; Hassan Dihazi; Alexander Beck; Gerhard A Mueller; Margret Mueller; Stefan Stevanovic; Claus Garbe; Claudia Mueller; Hubert Kalbacher
Cathepsin D is present in human eccrine sweat and involved in the postsecretory processing of the antimicrobial peptide DCD-1L.
The Journal of biological chemistry 2006;281(9):5406-15.
2006: Siegbert Rieg; Silke Seeber; Heiko Steffen; Andreas Humeny; Hubert Kalbacher; Stefan Stevanovic; Akihiko Kimura; Claus Garbe; Birgit Schittek
Generation of multiple stable dermcidin-derived antimicrobial peptides in sweat of different body sites.
The Journal of investigative dermatology 2006;126(2):354-65.
2005: Mike W Helms; Jens Packeisen; Christian August; Birgit Schittek; Werner Boecker; Burkhard Brandt; Horst Buerger
First evidence supporting a potential role for the BMP/SMAD pathway in the progression of oestrogen receptor-positive breast cancer.
The Journal of pathology 2005;206(3):366-76.
2005: Siegbert Rieg; Heiko Steffen; Silke Seeber; Andreas Humeny; Hubert Kalbacher; Klaus Dietz; Claus Garbe; Birgit Schittek
Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):8003-10.
2005: Friedegund Meier; Birgit Schittek; Silke Busch; Claus Garbe; Keiran Smalley; Kapaettu Satyamoorthy; Gang Li; Meenhard Herlyn
The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma.
Frontiers in bioscience : a journal and virtual library 2005;10():2986-3001.
2004: Siegbert Rieg; Claus Garbe; Birgit Sauer; Hubert Kalbacher; Birgit Schittek
Dermcidin is constitutively produced by eccrine sweat glands and is not induced in epidermal cells under inflammatory skin conditions.
The British journal of dermatology 2004;151(3):534-9.
2004: Ulrike Leiter; Friedegund Meier; Birgit Schittek; Claus Garbe
The natural course of cutaneous melanoma.
Journal of surgical oncology 2004;86(4):172-8.
2004: Hans-Juergen Blaheta; S Roeger; Karl Sotlar; Birgit Schittek; Helmut Breuninger; Burkhard D Bueltmann; Claus Garbe
Additional reverse transcription-polymerase chain reaction of peripheral slices is not superior to analysis of the central slice in sentinel lymph nodes from melanoma patients.
The British journal of dermatology 2004;150(3):477-83.
2004: Sebastian Tuve; Stephan N Wagner; Birgit Schittek; Brigitte M Pützer
Alterations of DeltaTA-p 73 splice transcripts during melanoma development and progression.
International journal of cancer. Journal international du cancer 2004;108(1):162-6.
2003: Friedegund Meier; Ulrich M Caroli; Kapaettu Satyamoorthy; Birgit Schittek; Jürgen Bauer; Carola Berking; Helga Möller; Evelyn Maczey; Gernot Rassner; Meenhard Herlyn; Claus Garbe
Fibroblast growth factor-2 but not Mel-CAM and/or beta3 integrin promotes progression of melanocytes to melanoma.
Experimental dermatology 2003;12(3):296-306.
2003: Claus Garbe; Ulrike Leiter; Ulf Ellwanger; Hans-Juergen Blaheta; Friedegund Meier; Gernot Rassner; Birgit Schittek
Diagnostic value and prognostic significance of protein S-100beta, melanoma-inhibitory activity, and tyrosinase/MART-1 reverse transcription-polymerase chain reaction in the follow-up of high-risk melanoma patients.
Cancer 2003;97(7):1737-45.
2003: Claus Garbe; Andrena Paul; Hanna Kohler-Späth; Ulf Ellwanger; Waltraud Stroebel; Monika Schwarz; Bettina Schlagenhauff; Friedegund Meier; Birgit Schittek; Hans-Juergen Blaheta; Andreas Blum; Gernot Rassner
Prospective evaluation of a follow-up schedule in cutaneous melanoma patients: recommendations for an effective follow-up strategy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(3):520-9.
2002: Thomas Flad; Ralf Bogumil; Jonathan Tolson; Birgit Schittek; Claus Garbe; Martin Deeg; Claudia Mueller; Hubert Kalbacher
Detection of dermcidin-derived peptides in sweat by ProteinChip technology.
Journal of immunological methods 2002;270(1):53-62.
2002: masamoto murakami; Takaaki Ohtake; Robert A Dorschner; Birgit Schittek; Claus Garbe; Richard L Gallo
Cathelicidin anti-microbial peptide expression in sweat, an innate defense system for the skin.
The Journal of investigative dermatology 2002;119(5):1090-5.
2002: Friedegund Meier; S Will; Ulf Ellwanger; Bettina Schlagenhauff; Birgit Schittek; Gernot Rassner; Claus Garbe
Metastatic pathways and time courses in the orderly progression of cutaneous melanoma.
The British journal of dermatology 2002;147(1):62-70.
2001: Birgit Schittek; R Hipfel; Birgit Sauer; Jürgen Bauer; Hubert Kalbacher; Stefan Stevanovic; Markus Schirle; K Schroeder; nikolaus blin; F Meier; Gernot Rassner; Claus Garbe
Dermcidin: a novel human antibiotic peptide secreted by sweat glands.
Nature immunology 2001;2(12):1133-7.
2001: Hans-Juergen Blaheta; T Paul; Karl Sotlar; Evelyn Maczey; Birgit Schittek; Andrena Paul; Matthias Moehrle; Helmut Breuninger; Burkhard D Bueltmann; Gernot Rassner; Claus Garbe
Detection of melanoma cells in sentinel lymph nodes, bone marrow and peripheral blood by a reverse transcription-polymerase chain reaction assay in patients with primary cutaneous melanoma: association with Breslow's tumour thickness.
The British journal of dermatology 2001;145(2):195-202.
2001: Karl S Lang; C C Caroli; A Muhm; Dorothee Wernet; Arnaud Moris; Birgit Schittek; E Knauss-Scherwitz; Stefan Stevanovic; Hans-Georg Rammensee; Claus Garbe
HLA-A2 restricted, melanocyte-specific CD8(+) T lymphocytes detected in vitiligo patients are related to disease activity and are predominantly directed against MelanA/MART1.
The Journal of investigative dermatology 2001;116(6):891-7.
2001: Hans-Juergen Blaheta; Birgit Schittek; Helmut Breuninger; Claus Garbe
Detection of micrometastasis in sentinel lymph nodes of patients with primary cutaneous melanoma.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2001;158():137-46.
2001: Birgit Schittek; Hans-Juergen Blaheta; Ulf Ellwanger; Claus Garbe
Polymerase chain reaction in the detection of circulating tumour cells in peripheral blood of melanoma patients.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2001;158():93-104.
2000: Bettina Schlagenhauff; Birgit Schittek; Ulf Ellwanger; Waltraud Stroebel; Andreas Blum; M Schwarz; Gernot Rassner; Claus Garbe
Significance of serum protein S100 levels in screening for melanoma metastasis: does protein S100 enable early detection of melanoma recurrence?
Melanoma research 2000;10(5):451-9.
2000: Benjamin Weide; Birgit Schittek; T Klyscz; K Schüz; M Stark; Gernot Rassner; B Wilske; Claus Garbe
Morphoea is neither associated with features of Borrelia burgdorferi infection, nor is this agent detectable in lesional skin by polymerase chain reaction.
The British journal of dermatology 2000;143(4):780-5.
2000: Hans-Juergen Blaheta; Ulf Ellwanger; Birgit Schittek; Karl Sotlar; Evelyn Maczey; Helmut Breuninger; MH Thelen; Burkhard D Bueltmann; Gernot Rassner; Claus Garbe
Examination of regional lymph nodes by sentinel node biopsy and molecular analysis provides new staging facilities in primary cutaneous melanoma.
The Journal of investigative dermatology 2000;114(4):637-42.
2000: R Hipfel; Birgit Schittek; Y Bodingbauer; Claus Garbe
Specifically regulated genes in malignant melanoma tissues identified by subtractive hybridization.
British journal of cancer 2000;82(6):1149-57.
1999: Birgit Schittek; Birgit Sauer; Claus Garbe
Lack of p73 mutations and late occurrence of p73 allelic deletions in melanoma tissues and cell lines.
International journal of cancer. Journal international du cancer 1999;82(4):583-6.
1999: Birgit Schittek; Hans-Juergen Blaheta; G Flörchinger; Birgit Sauer; Claus Garbe
Increased sensitivity for the detection of malignant melanoma cells in peripheral blood using an improved protocol for reverse transcription-polymerase chain reaction.
The British journal of dermatology 1999;141(1):37-43.
1999: Birgit Schittek; Y Bodingbauer; Ulf Ellwanger; Hans-Juergen Blaheta; Claus Garbe
Amplification of MelanA messenger RNA in addition to tyrosinase increases sensitivity of melanoma cell detection in peripheral blood and is associated with the clinical stage and prognosis of malignant melanoma.
The British journal of dermatology 1999;141(1):30-6.
1999: Hans-Juergen Blaheta; Birgit Schittek; Helmut Breuninger; Karl Sotlar; Ulf Ellwanger; MH Thelen; Evelyn Maczey; Gernot Rassner; Burkhard D Bueltmann; Claus Garbe
Detection of melanoma micrometastasis in sentinel nodes by reverse transcription-polymerase chain reaction correlates with tumor thickness and is predictive of micrometastatic disease in the lymph node basin.
The American journal of surgical pathology 1999;23(7):822-8.
1998: R Hipfel; Claus Garbe; Birgit Schittek
RNA isolation from human skin tissues for colorimetric differential display.
Journal of biochemical and biophysical methods 1998;37(3):131-5.
1998: Friedegund Meier; Kapaettu Satyamoorthy; Mark Nesbit; Mei-Yu Hsu; Birgit Schittek; C Garbe; Meenhard Herlyn
Molecular events in melanoma development and progression.
Frontiers in bioscience : a journal and virtual library 1998;3():D1005-10.
1998: Hans-Juergen Blaheta; Birgit Schittek; Helmut Breuninger; Evelyn Maczey; Stefan Kroeber; Karl Sotlar; Ulf Ellwanger; MH Thelen; Gernot Rassner; Burkhard D Bültmann; Claus Garbe
Lymph node micrometastases of cutaneous melanoma: increased sensitivity of molecular diagnosis in comparison to immunohistochemistry.
International journal of cancer. Journal international du cancer 1998;79(4):318-23.