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Michael Schlame

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TOP 3
Michael Schlame
Cardiolipin remodeling and the function of tafazzin.
Michael Schlame; David L Stokes; Salvatore Valvo; Yang Xu; Devrim Acehan; Bob Berno; Mindong Ren; Richard M Epand
The physical state of lipid substrates provides transacylation specificity for tafazzin.
Michael Schlame; Yang Xu; Colin K L Phoon; Mindong Ren; Steven Blais; Irit Edelman-Novemsky; Fleurise Montecillo; Thomas A Neubert
Comparison of cardiolipins from Drosophila strains with mutations in putative remodeling enzymes.

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All Publications

2013: Michael Schlame
Cardiolipin remodeling and the function of tafazzin.
Biochimica et biophysica acta 2013;1831(3):582-8.
2012: Michael Schlame; David L Stokes; Salvatore Valvo; Yang Xu; Devrim Acehan; Bob Berno; Mindong Ren; Richard M Epand
The physical state of lipid substrates provides transacylation specificity for tafazzin.
Nature chemical biology 2012;8(10):862-9.
2012: Michael Schlame; Yang Xu; Colin K L Phoon; Mindong Ren; Steven Blais; Irit Edelman-Novemsky; Fleurise Montecillo; Thomas A Neubert
Comparison of cardiolipins from Drosophila strains with mutations in putative remodeling enzymes.
Chemistry and physics of lipids 2012;165(5):512-9.
2012: Colin K L Phoon; Devrim Acehan; Irit Edelman-Novemsky; Michael Schlame; David L Stokes; Nitya Viswanathan; Yang Xu; Dawen Yu; Mindong Ren
Tafazzin knockdown in mice leads to a developmental cardiomyopathy with early diastolic dysfunction preceding myocardial noncompaction.
Journal of the American Heart Association 2012;1(2):.
2011: Devrim Acehan; Ashim Malhotra; Yang Xu; Mindong Ren; David L Stokes; Michael Schlame
Cardiolipin affects the supramolecular organization of ATP synthase in mitochondria.
Biophysical journal 2011;100(9):2184-92.
2009: Yang Xu; Shali Zhang; Ashim Malhotra; Irit Edelman-Novemsky; Jinping Ma; Antonina Kruppa; Carolina Cernicica; Steven Blais; Thomas A Neubert; Mindong Ren; Michael Schlame
Characterization of tafazzin splice variants from humans and fruit flies.
The Journal of biological chemistry 2009;284(42):29230-9.
2009: Michael Schlame; Mindong Ren
The role of cardiolipin in the structural organization of mitochondrial membranes.
Biochimica et biophysica acta 2009;1788(10):2080-3.
2009: Ashim Malhotra; Yang Xu; Mindong Ren; Michael Schlame
Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species.
Biochimica et biophysica acta 2009;1791(4):314-20.
2009: Michael Schlame
Formation of molecular species of mitochondrial cardiolipin 2. A mathematical model of pattern formation by phospholipid transacylation.
Biochimica et biophysica acta 2009;1791(4):321-5.
2009: Devrim Acehan; Zaza Khuchua; Riekelt H Houtkooper; Ashim Malhotra; Johanna Kaufman; Frédéric M Vaz; Mindong Ren; Howard A Rockman; David L Stokes; Michael Schlame
Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria.
Mitochondrion 2009;9(2):86-95.
2009: Ashim Malhotra; Irit Edelman-Novemsky; Yang Xu; Heide Plesken; Jinping Ma; Michael Schlame; Mindong Ren
Role of calcium-independent phospholipase A2 in the pathogenesis of Barth syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(7):2337-41.
2008: Michael Schlame
Cardiolipin synthesis for the assembly of bacterial and mitochondrial membranes.
Journal of lipid research 2008;49(8):1607-20.
2007: Françoise Hullin-Matsuda; Kiyoshi Kawasaki; Isabelle Delton-Vandenbroucke; Yang Xu; Masahiro Nishijima; Michel Lagarde; Michael Schlame; Toshihide Kobayashi
De novo biosynthesis of the late endosome lipid, bis(monoacylglycero)phosphate.
Journal of lipid research 2007;48(9):1997-2008.
2007: Michael Schlame
Assays of cardiolipin levels.
Methods in cell biology 2007;80():223-40.
2007: Devrim Acehan; Yang Xu; David L Stokes; Michael Schlame
Comparison of lymphoblast mitochondria from normal subjects and patients with Barth syndrome using electron microscopic tomography.
Laboratory investigation; a journal of technical methods and pathology 2007;87(1):40-8.
2006: Yang Xu; Ashim Malhotra; Mindong Ren; Michael Schlame
The enzymatic function of tafazzin.
The Journal of biological chemistry 2006;281(51):39217-24.
2006: Jung T Kim; Michael Wajda; Germaine Cuff; David Serota; Michael Schlame; Deborah M Axelrod; Amber A Guth; Alex Bekker
Evaluation of aromatherapy in treating postoperative pain: pilot study.
Pain practice : the official journal of World Institute of Pain 2006;6(4):273-7.
2006: Michael Schlame; Mindong Ren
Barth syndrome, a human disorder of cardiolipin metabolism.
FEBS letters 2006;580(23):5450-5.
2006: Yang Xu; Morgan Condell; Heide Plesken; Irit Edelman-Novemsky; Jinping Ma; Mindong Ren; Michael Schlame
A Drosophila model of Barth syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11584-8.
2005: Michael Schlame; Mindong Ren; Yang Xu; Miriam L. Greenberg; Ivan Haller
Molecular symmetry in mitochondrial cardiolipins.
Chemistry and physics of lipids 2005;138(1-2):38-49.
2005: VISHAL GOHIL; Jelena Gvozdenovic-Jeremic; Michael Schlame; Miriam L. Greenberg
Binding of 10-N-nonyl acridine orange to cardiolipin-deficient yeast cells: implications for assay of cardiolipin.
Analytical biochemistry 2005;343(2):350-2.
2005: Yang Xu; John J Sutachan; Heide Plesken; Richard I Kelley; Michael Schlame
Characterization of lymphoblast mitochondria from patients with Barth syndrome.
Laboratory investigation; a journal of technical methods and pathology 2005;85(6):823-30.
2005: Angelika Tölle; Michael Schlame; Nico Charlier; Florian Guthmann; Bernd Rüstow
Vitamin E differentially regulates the expression of peroxiredoxin-1 and -6 in alveolar type II cells.
Free radical biology & medicine 2005;38(10):1401-8.
2004: VISHAL GOHIL; Paulette Hayes; Shigemi Matsuyama; Hermann Schägger; Michael Schlame; Miriam L. Greenberg
Cardiolipin biosynthesis and mitochondrial respiratory chain function are interdependent.
The Journal of biological chemistry 2004;279(41):42612-8.
2003: Yang Xu; Richard I Kelley; Thomas J J Blanck; Michael Schlame
Remodeling of cardiolipin by phospholipid transacylation.
The Journal of biological chemistry 2003;278(51):51380-5.
2003: Michael Schlame; Richard I Kelley; Annette Feigenbaum; Jeffrey A Towbin; Paul M Heerdt; Thomas Schieble; Ronald J A Wanders; Salvatore DiMauro; Thomas J J Blanck
Phospholipid abnormalities in children with Barth syndrome.
Journal of the American College of Cardiology 2003;42(11):1994-9.
2003: Florian Guthmann; Ingrid Kolleck; Christian Schachtrup; Michael Schlame; Friedrich Spener; Bernd Rüstow
Vitamin E deficiency reduces surfactant lipid biosynthesis in alveolar type II cells.
Free radical biology & medicine 2003;34(6):663-73.
2002: Bettina Frey; Wolfram Johnen; Renate Haupt; Hartmut Kern; Bernd Rüstow; Wolfgang J Kox; Michael Schlame
Bioactive oxidized lipids in the plasma of cardiac surgical intensive care patients.
Shock (Augusta, Ga.) 2002;18(1):14-7.
2002: Ingrid Kolleck; Heide Wissel; Florian Guthmann; Michael Schlame; Pranav Sinha; Bernd Rüstow
HDL-holoparticle uptake by alveolar type II cells: effect of vitamin E status.
American journal of respiratory cell and molecular biology 2002;27(1):57-63.
2002: Pranav Sinha; Ingrid Kolleck; Hans Dieter Volk; Michael Schlame; Bernd Rüstow
Vitamin E deficiency sensitizes alveolar type II cells for apoptosis.
Biochimica et biophysica acta 2002;1583(1):91-8.
2002: Ingrid Kolleck; Florian Guthmann; Axel-M Ladhoff; Narendra Tandon; Michael Schlame; Bernd Rüstow
Cellular cholesterol stimulates acute uptake of palmitate by redistribution of fatty acid translocase in type II pneumocytes.
Biochemistry 2002;41(20):6369-75.
2002: Michael Schlame; Jeffrey A Towbin; Paul M Heerdt; Roswitha Jehle; Salvatore DiMauro; Thomas J J Blanck
Deficiency of tetralinoleoyl-cardiolipin in Barth syndrome.
Annals of neurology 2002;51(5):634-7.
2002: Paul M Heerdt; Michael Schlame; Roswitha Jehle; Alessandro Barbone; Daniel Burkhoff; Thomas J J Blanck
Disease-specific remodeling of cardiac mitochondria after a left ventricular assist device.
The Annals of thoracic surgery 2002;73(4):1216-21.
2001: Michael Schlame; Ivan Haller; Lisa Sammaritano; Thomas J J Blanck
Effect of cardiolipin oxidation on solid-phase immunoassay for antiphospholipid antibodies.
Thrombosis and haemostasis 2001;86(6):1475-82.
2001: Roswitha Jehle; Michael Schlame; C Büttner; B Frey; Pranav Sinha; Bernd Rüstow
Platelet-activating factor (PAF)-acetylhydrolase and PAF-like compounds in the lung: effects of hyperoxia.
Biochimica et biophysica acta 2001;1532(1-2):60-6.
2000: Hartmut Kern; W Johnen; J Braun; B Frey; Bernd Rüstow; Wolfgang J Kox; Michael Schlame
Heparin induces release of phospholipase A(2) into the splanchnic circulation.
Anesthesia and analgesia 2000;91(3):528-32.
2000: F Jiang; M T Ryan; Michael Schlame; M Zhao; Zhiming Gu; M Klingenberg; N Pfanner; Miriam L. Greenberg
Absence of cardiolipin in the crd1 null mutant results in decreased mitochondrial membrane potential and reduced mitochondrial function.
The Journal of biological chemistry 2000;275(29):22387-94.
2000: B Frey; Renate Haupt; S Alms; G Holzmann; T König; Hartmut Kern; Wolfgang J Kox; Bernd Rüstow; Michael Schlame
Increase in fragmented phosphatidylcholine in blood plasma by oxidative stress.
Journal of lipid research 2000;41(7):1145-53.
2000: Michael Schlame; D Rua; Miriam L. Greenberg
The biosynthesis and functional role of cardiolipin.
Progress in lipid research 2000;39(3):257-88.
1999: Ingrid Kolleck; Michael Schlame; Henry Fechner; Alfred Looman; Heide Wissel; Bernd Rüstow
HDL is the major source of vitamin E for type II pneumocytes.
Free radical biology & medicine 1999;27(7-8):882-90.
1999: Michael Schlame; S Shanske; S Doty; T König; T Sculco; Salvatore DiMauro; Thomas J J Blanck
Microanalysis of cardiolipin in small biopsies including skeletal muscle from patients with mitochondrial disease.
Journal of lipid research 1999;40(9):1585-92.
1998: Hartmut Kern; T Volk; S Knauer-Schiefer; T Mieth; Bernd Rüstow; Wolfgang J Kox; Michael Schlame
Stimulation of monocytes and platelets by short-chain phosphatidylcholines with and without terminal carboxyl group.
Biochimica et biophysica acta 1998;1394(1):33-42.
1998: Michael Schlame; A B Schmid; Renate Haupt; Bernd Rüstow; Wolfgang J Kox
Study of platelet-activating factor acetylhydrolase in the perioperative period of patients undergoing cardiac surgery.
Shock (Augusta, Ga.) 1998;9(5):313-9.
1998: Henry Fechner; Michael Schlame; Florian Guthmann; PA Stevens; Bernd Rüstow
alpha- and delta-tocopherol induce expression of hepatic alpha-tocopherol-transfer-protein mRNA.
The Biochemical journal 1998;331 ( Pt 2)():577-81.
1998: M Zhao; Michael Schlame; D Rua; Miriam L. Greenberg
Cardiolipin synthase is associated with a large complex in yeast mitochondria.
The Journal of biological chemistry 1998;273(4):2402-8.
1997: Michael Schlame; K Y Hostetler
Cardiolipin synthase from mammalian mitochondria.
Biochimica et biophysica acta 1997;1348(1-2):207-13.
1997: Angelika Tölle; Ingrid Kolleck; Michael Schlame; Roland R Wauer; PA Stevens; Bernd Rüstow
Effect of hyperoxia on the composition of the alveolar surfactant and the turnover of surfactant phospholipids, cholesterol, plasmalogens and vitamin E.
Biochimica et biophysica acta 1997;1346(2):198-204.
1996: Michael Schlame; R Haupt; I Wiswedel; W J Kox; B Rüstow
Identification of short-chain oxidized phosphatidylcholine in human plasma.
Journal of lipid research 1996;37(12):2608-15.
1995: Florian Guthmann; R Haupt; Michael Schlame; P A Stevens; Bernd Rüstow
Alveolar surfactant subfractions differ in their lipid composition.
The international journal of biochemistry & cell biology 1995;27(10):1021-6.
1994: B Hoffmann; A Stöckl; Michael Schlame; K Beyer; Martin Klingenberg
The reconstituted ADP/ATP carrier activity has an absolute requirement for cardiolipin as shown in cysteine mutants.
The Journal of biological chemistry 1994;269(3):1940-4.
1993: Michael Schlame; S Brody; Karl Y Hostetler
Mitochondrial cardiolipin in diverse eukaryotes. Comparison of biosynthetic reactions and molecular acyl species.
European journal of biochemistry / FEBS 1993;212(3):727-35.
1992: Bernd Rüstow; Michael Schlame; R Haupt; D Wilhelm; D Kunze
Studies on the formation of dipalmitoyl species of phosphatidylcholine and phosphatidylethanolamine in pulmonary type II cells.
The Biochemical journal 1992;282 ( Pt 2)():453-8.
1992: Michael Schlame; Karl Y Hostetler
Mammalian cardiolipin biosynthesis.
Methods in enzymology 1992;209():330-7.
1991: Michael Schlame; Karl Y Hostetler
Solubilization, purification, and characterization of cardiolipin synthase from rat liver mitochondria. Demonstration of its phospholipid requirement.
The Journal of biological chemistry 1991;266(33):22398-403.
1991: G M van Wijk; Karl Y Hostetler; Michael Schlame; H van den Bosch
Cytidine diphosphate diglyceride analogs of antiretroviral dideoxynucleosides: evidence for release of dideoxynucleoside-monophosphates by phospholipid biosynthetic enzymes in rat liver subcellular fractions.
Biochimica et biophysica acta 1991;1086(1):99-105.
1991: Michael Schlame; K Beyer; M Hayer-Hartl; Martin Klingenberg
Molecular species of cardiolipin in relation to other mitochondrial phospholipids. Is there an acyl specificity of the interaction between cardiolipin and the ADP/ATP carrier?
European journal of biochemistry / FEBS 1991;199(2):459-66.
1991: Michael Schlame; D Otten
Analysis of cardiolipin molecular species by high-performance liquid chromatography of its derivative 1,3-bisphosphatidyl-2-benzoyl-sn-glycerol dimethyl ester.
Analytical biochemistry 1991;195(2):290-5.
1990: Michael Schlame; Bernd Rüstow
Lysocardiolipin formation and reacylation in isolated rat liver mitochondria.
The Biochemical journal 1990;272(3):589-95.
1989: Bernd Rüstow; Michael Schlame; H Rabe; G Reichmann; D Kunze
Species pattern of phosphatidic acid, diacylglycerol, CDP-diacylglycerol and phosphatidylglycerol synthesized de novo in rat liver mitochondria.
Biochimica et biophysica acta 1989;1002(2):261-3.
1989: Michael Schlame; Bernd Rüstow; D Kunze
Synthesis of phosphatidylcholine and phosphatidylglycerol in rat lung mitochondria.
Molecular and cellular biochemistry 1989;85(2):115-22.
1988: Michael Schlame; C Casals; Bernd Rüstow; H Rabe; D Kunze
Molecular species of phosphatidylcholine and phosphatidylglycerol in rat lung surfactant and different pools of pneumocytes type II.
The Biochemical journal 1988;253(1):209-15.
1988: Michael Schlame; H Rabe; Bernd Rüstow; D Kunze
Molecular species of mitochondrial phosphatidylcholine in rat liver and lung.
Biochimica et biophysica acta 1988;958(3):493-6.
1986: Michael Schlame; Bernd Rüstow; D Kunze; H Rabe; G Reichmann
Phosphatidylglycerol of rat lung. Intracellular sites of formation de novo and acyl species pattern in mitochondria, microsomes and surfactant.
The Biochemical journal 1986;240(1):247-52.