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William Schleif

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Danilo R Casimiro; Kara Cox; Aimin Tang; Kara J Sykes; Meizhen Feng; Fubao Wang; Andrew Bett; William A Schleif; Xiaoping Liang; Jessica Flynn; Timothy W Tobery; Keith Wilson; Adam Finnefrock; Lingyi Huang; Salvatore Vitelli; Jing Lin; Deepa Patel; Mary-Ellen Davies; Gwendolyn J Heidecker; Daniel C Freed; Sheri Dubey; David H O'Connor; David Ian Watkins; Zhi-Qiang Zhang; John W Shiver
Efficacy of multivalent adenovirus-based vaccine against simian immunodeficiency virus challenge.
Leslie L Chavez; Miles P Davenport; John W Shiver; Lynda G Tussey; Kara S Cox; Margaret Bachinsky; Fubao Wang; Lingyi Huang; William A Schleif; Mary-Ellen Davies; Aimin Tang; Danilo R Casimiro; Alan S Perelson; Ruy M Ribeiro
The effect of early versus delayed challenge after vaccination in controlling SHIV 89.6P infection.
Jeffrey Y Melamed; Melissa S Egbertson; Sandor L Varga; Joseph P Vacca; Gregory Moyer; Lori Gabryelski; Peter J Felock; Kara A Stillmock; Marc V Witmer; William A Schleif; Daria J Hazuda; Yvonne M Leonard; Lixia Jin; Joan D Ellis; Steven D Young
Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.

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All Publications

2010: Danilo R Casimiro; Kara Cox; Aimin Tang; Kara J Sykes; Meizhen Feng; Fubao Wang; Andrew Bett; William A Schleif; Xiaoping Liang; Jessica Flynn; Timothy W Tobery; Keith Wilson; Adam Finnefrock; Lingyi Huang; Salvatore Vitelli; Jing Lin; Deepa Patel; Mary-Ellen Davies; Gwendolyn J Heidecker; Daniel C Freed; Sheri Dubey; David H O'Connor; David Ian Watkins; Zhi-Qiang Zhang; John W Shiver
Efficacy of multivalent adenovirus-based vaccine against simian immunodeficiency virus challenge.
Journal of virology 2010;84(6):2996-3003.
2008: Leslie L Chavez; Miles P Davenport; John W Shiver; Lynda G Tussey; Kara S Cox; Margaret Bachinsky; Fubao Wang; Lingyi Huang; William A Schleif; Mary-Ellen Davies; Aimin Tang; Danilo R Casimiro; Alan S Perelson; Ruy M Ribeiro
The effect of early versus delayed challenge after vaccination in controlling SHIV 89.6P infection.
Virology 2008;381(1):75-80.
2008: Jeffrey Y Melamed; Melissa S Egbertson; Sandor L Varga; Joseph P Vacca; Gregory Moyer; Lori Gabryelski; Peter J Felock; Kara A Stillmock; Marc V Witmer; William A Schleif; Daria J Hazuda; Yvonne M Leonard; Lixia Jin; Joan D Ellis; Steven D Young
Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.
Bioorganic & medicinal chemistry letters 2008;18(19):5307-10.
2008: Catherine M Wiscount; Peter D Williams; Lekhanh O Tran; Mark W Embrey; Thorsten E Fisher; Vanessa Sherman; Carl F Homnick; D Donnette Staas; Terry A Lyle; John S Wai; Joseph P Vacca; ZiQiang Wang; Peter J Felock; Kara A Stillmock; Marc V Witmer; Michael D Miller; Daria J Hazuda; Alysha M Day; Lori Gabryelski; Linda T Ecto; William A Schleif; Daniel J DiStefano; Christopher J Kochansky; M Reza Anari
10-Hydroxy-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-diones: potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants.
Bioorganic & medicinal chemistry letters 2008;18(16):4581-3.
2008: H Marie Langford; Peter D Williams; Carl F Homnick; Joseph P Vacca; Peter J Felock; Kara A Stillmock; Marc V Witmer; Daria J Hazuda; Lori Gabryelski; William A Schleif
Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(2):721-5.
2007: Thorsten E Fisher; Boyoung Kim; Donnette D Staas; Terry A Lyle; Steven D Young; Joseph P Vacca; Matthew M Zrada; Daria J Hazuda; Peter J Felock; William A Schleif; Lori Gabryelski; M Reza Anari; Christopher J Kochansky; John S Wai
8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(23):6511-5.
2007: John S Wai; Boyoung Kim; Thorsten E Fisher; Linghang Zhuang; Mark W Embrey; Peter D Williams; Donnette D Staas; Chris Culberson; Terry A Lyle; Joseph P Vacca; Daria J Hazuda; Peter J Felock; William A Schleif; Lori Gabryelski; Lixia Jin; I-Wu Chen; Joan D Ellis; Rama Mallai; Steven D Young
Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(20):5595-9.
2007: Subharekha Raghavan; Zhijian Lu; Teresa Beeson; Kevin Chapman; William A Schleif; David B Olsen; Mark Stahlhut; Carrie A Rutkowski; Lori Gabryelski; Emilio A Emini; James R Tata
Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus.
Bioorganic & medicinal chemistry letters 2007;17(19):5432-6.
2007: Zhi-Qiang Zhang; Danilo R Casimiro; William A Schleif; Minchun Chen; Michael P Citron; Mary-Ellen Davies; Janine Burns; Xiaoping Liang; Tong-Ming Fu; Larry Handt; Emilio A Emini; John W Shiver
Early depletion of proliferating B cells of germinal center in rapidly progressive simian immunodeficiency virus infection.
Virology 2007;361(2):455-64.
2007: Melissa S Egbertson; H Marie Moritz; Jeffrey Y Melamed; Wei Han; Debra S Perlow; Michelle Kuo; Mark W Embrey; Joseph P Vacca; Matthew M Zrada; Amanda R Cortes; Audrey Wallace; Yvonne M Leonard; Daria J Hazuda; Michael D Miller; Peter J Felock; Kara A Stillmock; Marc V Witmer; William A Schleif; Lori Gabryelski; Gregory Moyer; Joan D Ellis; Lixia Jin; Wei Xu; Matthew P Braun; Kelem Kassahun; Nancy N Tsou; Steven D Young
A potent and orally active HIV-1 integrase inhibitor.
Bioorganic & medicinal chemistry letters 2007;17(5):1392-8.
2006: kausik chakraborty; Venuka Durani; Edward Roshan Miranda; Michael P Citron; Xiaoping Liang; William A Schleif; Joseph G Joyce; Raghavan Varadarajan
Design of immunogens that present the crown of the HIV-1 V3 loop in a conformation competent to generate 447-52D-like antibodies.
The Biochemical journal 2006;399(3):483-91.
2006: James P Guare; John S Wai; Robert P Gomez; Neville J Anthony; Samson M Jolly; Amanda R Cortes; Joseph P Vacca; Peter J Felock; Kara A Stillmock; William A Schleif; Gregory Moyer; Lori Gabryelski; Lixia Jin; I-Wu Chen; Daria J Hazuda; Steven D Young
A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(11):2900-4.
2006: Amos B Smith; Adam K Charnley; Hironori Harada; Jason J Beiger; Louis-David Cantin; Craig S Kenesky; Ralph Hirschmann; Sanjeev Munshi; David B Olsen; Mark Stahlhut; William A Schleif; Lawrence C Kuo
Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors possessing augmented P2' side chains.
Bioorganic & medicinal chemistry letters 2006;16(4):859-63.
2005: Adrian B McDermott; David O'Connor; Sarah Fuenger; Shari M Piaskowski; Sarah Martin; John T Loffredo; Matthew Reynolds; Jason Reed; Jessica Furlott; Timothy Jacoby; Cara Riek; Elizabeth J Dodds; Kendall C Krebs; Mary-Ellen Davies; William A Schleif; Danilo R Casimiro; John W Shiver; David Ian Watkins
Cytotoxic T-lymphocyte escape does not always explain the transient control of simian immunodeficiency virus SIVmac239 viremia in adenovirus-boosted and DNA-primed Mamu-A*01-positive rhesus macaques.
Journal of virology 2005;79(24):15556-66.
2005: Zhijian Lu; Joann Bohn; Thomas A Rano; Carrie A Rutkowski; Amy L Simcoe; David B Olsen; William A Schleif; Anthony Carella; Lori Gabryelski; Lixia Jin; Jiunn H Lin; Emilio A Emini; Kevin Chapman; James R Tata
Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus.
Bioorganic & medicinal chemistry letters 2005;15(23):5311-4.
2005: Mark W Embrey; John S Wai; Timothy W Funk; Carl F Homnick; Debra S Perlow; Steven D Young; Joseph P Vacca; Daria J Hazuda; Peter J Felock; Kara A Stillmock; Marc V Witmer; Gregory Moyer; William A Schleif; Lori Gabryelski; Lixia Jin; I-Wu Chen; Joan D Ellis; Bradley K Wong; Jiunn H Lin; Yvonne M Leonard; Nancy N Tsou; Linghang Zhuang
A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.
Bioorganic & medicinal chemistry letters 2005;15(20):4550-4.
2005: Xiaoping Liang; Danilo R Casimiro; William A Schleif; Fubao Wang; Mary-Ellen Davies; Zhi-Qiang Zhang; Tong-Ming Fu; Adam C Finnefrock; Larry Handt; Michael P Citron; Gwendolyn J Heidecker; Aimin Tang; Minchun Chen; Keith A Wilson; Lori Gabryelski; Michael McElhaugh; Anthony Carella; Cheryl Moyer; Lingyi Huang; Salvatore Vitelli; Deepa Patel; Jing Lin; Emilio A Emini; John W Shiver
Vectored Gag and Env but not Tat show efficacy against simian-human immunodeficiency virus 89.6P challenge in Mamu-A*01-negative rhesus monkeys.
Journal of virology 2005;79(19):12321-31.
2005: Elisabetta Bianchi; Marco Finotto; Paolo Ingallinella; Renee Hrin; Anthony V Carella; Xiaoli S Hou; William A Schleif; Michael D Miller; Romas Geleziunas; Antonello Pessi
Covalent stabilization of coiled coils of the HIV gp41 N region yields extremely potent and broad inhibitors of viral infection.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(36):12903-8.
2005: Miles P Davenport; Lei Zhang; Ansuman Bagchi; Arthur Fridman; Tong-Ming Fu; William A Schleif; John W Shiver; Ruy M Ribeiro; Alan S Perelson
High-potency human immunodeficiency virus vaccination leads to delayed and reduced CD8+ T-cell expansion but improved virus control.
Journal of virology 2005;79(15):10059-62.
2005: Dooseop Kim; Liping Wang; Jeffrey J Hale; Christopher L Lynch; Richard J Budhu; Malcolm MacCoss; Sander G Mills; Lorraine Malkowitz; Sandra L Gould; Julie A DeMartino; Martin S Springer; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee C Hrin; Gwen Carver; Anthony Carella; Karen Henry; Janet Lineberger; William A Schleif; Emilio A Emini
Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties.
Bioorganic & medicinal chemistry letters 2005;15(8):2129-34.
2005: Shrenik K Shah; Natalie Chen; Ravindra N Guthikonda; Sander G Mills; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini; Malcolm MacCoss
Synthesis and evaluation of CCR5 antagonists containing modified 4-piperidinyl-2-phenyl-1-(phenylsulfonylamino)-butane.
Bioorganic & medicinal chemistry letters 2005;15(4):977-82.
2005: Raghavan Varadarajan; Deepak Sharma; kausik chakraborty; Mayuri Patel; Michael P Citron; Prem Sinha; Ram Kishor Yadav; Umar Rashid; Sarah Kennedy; Debra M Eckert; Romas Geleziunas; David Bramhill; William A Schleif; Xiaoping Liang; John W Shiver
Characterization of gp120 and its single-chain derivatives, gp120-CD4D12 and gp120-M9: implications for targeting the CD4i epitope in human immunodeficiency virus vaccine design.
Journal of virology 2005;79(3):1713-23.
2004: Sanjib Bera; Leila Malik; Balkrishen Bhat; Steven S Carroll; Renee Hrin; Malcolm MacCoss; Daniel R McMasters; Michael D Miller; Greg Moyer; David B Olsen; William A Schleif; Joanne E Tomassini; Anne B Eldrup
Synthesis and biological evaluation of 5R- and 5S-methyl substituted D- and L-configuration 1,3-dioxolane nucleoside analogs.
Bioorganic & medicinal chemistry 2004;12(23):6237-47.
2004: Ronald M Kim; Elizabeth A Rouse; Kevin Chapman; William A Schleif; David B Olsen; Mark Stahlhut; Carrie A Rutkowski; Emilio A Emini; James R Tata
P1' oxadiazole protease inhibitors with excellent activity against native and protease inhibitor-resistant HIV-1.
Bioorganic & medicinal chemistry letters 2004;14(18):4651-4.
2004: Daria J Hazuda; Steven D Young; James P Guare; Neville J Anthony; Robert P Gomez; John S Wai; Joseph P Vacca; Larry Handt; Sherri L Motzel; Hilton J Klein; Geethanjali Dornadula; Robert M Danovich; Marc V Witmer; Keith A Wilson; Lynda Tussey; William A Schleif; Lori S Gabryelski; Lixia Jin; Michael D Miller; Danilo R Casimiro; Emilio A Emini; John W Shiver
Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques.
Science (New York, N.Y.) 2004;305(5683):528-32.
2004: K Shankaran; Karla L Donnelly; Shrenik K Shah; Charles G Caldwell; Ping Chen; Paul E Finke; Bryan Oates; Malcolm MacCoss; Sander G Mills; Julie A DeMartino; Sandra L Gould; Lorraine Malkowitz; Salvatore J Siciliano; Martin S Springer; Gloria Y Kwei; Anthony Carella; Gwen Carver; Renee Danzeisen; Daria J Hazuda; Karen Holmes; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini; William A Schleif
Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists.
Bioorganic & medicinal chemistry letters 2004;14(13):3589-93.
2004: K Shankaran; Karla L Donnelly; Shrenik K Shah; Ravindra N Guthikonda; Malcolm MacCoss; Sander G Mills; Sandra L Gould; Lorraine Malkowitz; Salvatore J Siciliano; Martin S Springer; Anthony Carella; Gwen Carver; Daria J Hazuda; Karen Holmes; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini; William A Schleif
Syntheses and SAR studies of 4-(heteroarylpiperdin-1-yl-methyl)-pyrrolidin-1-yl-acetic acid antagonists of the human CCR5 chemokine receptor.
Bioorganic & medicinal chemistry letters 2004;14(13):3419-24.
2004: David Opalka; Antonello Pessi; Elisabetta Bianchi; Gennaro Ciliberto; William A Schleif; Michael McElhaugh; Renee Danzeisen; Romas Geleziunas; Michael Miller; Debra M Eckert; David Bramhill; Joseph Joyce; James Cook; William Magilton; John W Shiver; Emilio A Emini; MARK ESSER
Analysis of the HIV-1 gp41 specific immune response using a multiplexed antibody detection assay.
Journal of immunological methods 2004;287(1-2):49-65.
2004: Zhi-Qiang Zhang; William A Schleif; Danilo R Casimiro; Larry Handt; Minchun Chen; Mary-Ellen Davies; Xiaoping Liang; Tong-Ming Fu; Aimin Tang; Keith A Wilson; Michael McElhaugh; Anthony Carella; Charles Tan; Brett Connolly; Susan Hill; Hilton Klein; Emilio A Emini; John W Shiver
The impact of early immune destruction on the kinetics of postacute viral replication in rhesus monkey infected with the simian-human immunodeficiency virus 89.6P.
Virology 2004;320(1):75-84.
2004: Min Shu; Jennifer L Loebach; Kerry A Parker; Sander G Mills; Kevin Chapman; Dong-Ming Shen; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Jerry Di Salvo; Kathryn Lyons; James V Pivnichny; Gloria Y Kwei; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment.
Bioorganic & medicinal chemistry letters 2004;14(4):947-52.
2004: Dong-Ming Shen; Min Shu; Christopher A Willoughby; Shrenik Shah; Christopher L Lynch; Jeffrey J Hale; Sander G Mills; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Kathryn Lyons; James V Pivnichny; Gloria Y Kwei; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds.
Bioorganic & medicinal chemistry letters 2004;14(4):941-5.
2004: Dong-Ming Shen; Min Shu; Sander G Mills; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Gloria Y Kwei; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains.
Bioorganic & medicinal chemistry letters 2004;14(4):935-9.
2003: Nancy J Kevin; Joseph L Duffy; Brian A Kirk; Kevin Chapman; William A Schleif; David B Olsen; Mark Stahlhut; Carrie A Rutkowski; Lawrence C Kuo; Lixia Jin; Jiunn H Lin; Emilio A Emini; James R Tata
Novel HIV-1 protease inhibitors active against multiple PI-resistant viral strains: coadministration with indinavir.
Bioorganic & medicinal chemistry letters 2003;13(22):4027-30.
2003: Joseph L Duffy; Brian A Kirk; Nancy J Kevin; Kevin Chapman; William A Schleif; David B Olsen; Mark Stahlhut; Carrie A Rutkowski; Lawrence C Kuo; Lixia Jin; Jiunn H Lin; Emilio A Emini; James R Tata
HIV-1 protease inhibitors with picomolar potency against PI-resistant HIV-1 by modification of the P1' substituent.
Bioorganic & medicinal chemistry letters 2003;13(19):3323-6.
2003: Sheo B Singh; John G Ondeyka; William A Schleif; Peter J Felock; Daria J Hazuda
Chemistry and structure-activity relationship of HIV-1 integrase inhibitor integracide B and related natural products.
Journal of natural products 2003;66(10):1338-44.
2003: Rafael E Campo; Jose N Moreno; German Suarez; Nancimae Miller; Michael A Kolber; Daniel J Holder; Malathi Shivaprakash; Dana M DeAngelis; Jennifer L Wright; William A Schleif; Emilio A Emini; Jon H Condra
Efficacy of indinavir-ritonavir-based regimens in HIV-1-infected patients with prior protease inhibitor failures.
AIDS (London, England) 2003;17(13):1933-9.
2003: Fengqi Zhang; Kevin Chapman; William A Schleif; David B Olsen; Mark Stahlhut; Carrie A Rutkowski; Lawrence C Kuo; Lixia Jin; Jiunn H Lin; Emilio A Emini; James R Tata
The design, synthesis and evaluation of novel HIV-1 protease inhibitors with high potency against PI-resistant viral strains.
Bioorganic & medicinal chemistry letters 2003;13(15):2573-6.
2003: Joseph L Duffy; Thomas A Rano; Nancy J Kevin; Kevin Chapman; William A Schleif; David B Olsen; Mark Stahlhut; Carrie A Rutkowski; Lawrence C Kuo; Lixia Jin; Jiunn H Lin; Emilio A Emini; James R Tata
HIV protease inhibitors with picomolar potency against PI-Resistant HIV-1 by extension of the P3 substituent.
Bioorganic & medicinal chemistry letters 2003;13(15):2569-72.
2003: Christopher L Lynch; Jeffrey J Hale; Richard J Budhu; Amy L Gentry; Paul E Finke; Charles G Caldwell; Sander G Mills; Malcolm MacCoss; Dong-Ming Shen; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activity.
Organic letters 2003;5(14):2473-5.
2003: Zhijian Lu; Subharekha Raghavan; Joann Bohn; Mark Charest; Mark Stahlhut; Carrie A Rutkowski; Amy L Simcoe; David B Olsen; William A Schleif; Anthony Carella; Lori Gabryelski; Lixia Jin; Jiunn H Lin; Emilio A Emini; Kevin Chapman; James R Tata
Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus.
Bioorganic & medicinal chemistry letters 2003;13(10):1821-4.
2003: Amos B Smith; Louis-David Cantin; Alexander Pasternak; Lisa Guise-Zawacki; Wenquin Yao; Adam K Charnley; Joseph Barbosa; Paul A Sprengeler; Ralph Hirschmann; Sanjeev Munshi; David B Olsen; William A Schleif; Lawrence C Kuo
Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors.
Journal of medicinal chemistry 2003;46(10):1831-44.
2003: Linghang Zhuang; John S Wai; Mark W Embrey; Thorsten E Fisher; Melissa S Egbertson; Linda S Payne; James P Guare; Joseph P Vacca; Daria J Hazuda; Peter J Felock; Abigail L Wolfe; Kara A Stillmock; Marc V Witmer; Gregory Moyer; William A Schleif; Lori Gabryelski; Yvonne M Leonard; Joseph J Lynch; Stuart R Michelson; Steven D Young
Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.
Journal of medicinal chemistry 2003;46(4):453-6.
2003: Christopher A Willoughby; Keith G Rosauer; Jeffrey J Hale; Richard J Budhu; Sander G Mills; Kevin Chapman; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
1,3,4 Trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains.
Bioorganic & medicinal chemistry letters 2003;13(3):427-31.
2003: Christopher L Lynch; Christopher A Willoughby; Jeffrey J Hale; Edward J Holson; Richard J Budhu; Amy L Gentry; Keith G Rosauer; Charles G Caldwell; Ping Chen; Sander G Mills; Malcolm MacCoss; Scott Berk; Liya Chen; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains.
Bioorganic & medicinal chemistry letters 2003;13(1):119-23.
2002: Zhi-Qiang Zhang; Tong-Ming Fu; Danilo R Casimiro; Mary-Ellen Davies; Xiaoping Liang; William A Schleif; Larry Handt; Lynda Tussey; Minchun Chen; Aimin Tang; Keith A Wilson; Wendy Trigona; Daniel C Freed; Charles Y Tan; Melanie Horton; Emilio A Emini; John W Shiver
Mamu-A*01 allele-mediated attenuation of disease progression in simian-human immunodeficiency virus infection.
Journal of virology 2002;76(24):12845-54.
2002: Christopher L Lynch; Jeffrey J Hale; Richard J Budhu; Amy L Gentry; Sander G Mills; Kevin Chapman; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.
Bioorganic & medicinal chemistry letters 2002;12(20):3001-4.
2002: Jeffrey J Hale; Richard J Budhu; Sander G Mills; Malcolm MacCoss; Sandra L Gould; Julie A DeMartino; Martin S Springer; Salvatore J Siciliano; Lorraine Malkowitz; William A Schleif; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Karen Holmes; Janet Lineberger; Anthony Carella; Gwen Carver; Emilio A Emini
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: polar functionality and its effect on anti-HIV-1 activity.
Bioorganic & medicinal chemistry letters 2002;12(20):2997-3000.
2002: Subharekha Raghavan; Zheng Yang; Ralph T Mosley; William A Schleif; Lori Gabryelski; David B Olsen; Mark Stahlhut; Lawrence C Kuo; Emilio A Emini; Kevin Chapman; James R Tata
Combinatorial library of indinavir analogues: replacement for the aminoindanol at P2'.
Bioorganic & medicinal chemistry letters 2002;12(20):2855-8.
2002: Joseph L Duffy; Nancy J Kevin; Brian A Kirk; Kevin Chapman; William A Schleif; David B Olsen; Mark Stahlhut; Carrie A Rutkowski; Lawrence C Kuo; Lixia Jin; Jiunn H Lin; Emilio A Emini; James R Tata
Synthesis and activity of novel HIV protease inhibitors with improved potency against multiple PI-resistant viral strains.
Bioorganic & medicinal chemistry letters 2002;12(17):2423-6.
2002: Yuan Cheng; Fengqi Zhang; Thomas A Rano; Zhijian Lu; William A Schleif; Lori Gabryelski; David B Olsen; Mark Stahlhut; Carrie A Rutkowski; Jiunn H Lin; Lixia Jin; Emilio A Emini; Kevin Chapman; James R Tata
Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-resistant viral strains.
Bioorganic & medicinal chemistry letters 2002;12(17):2419-22.
2002: Christopher L Lynch; Amy L Gentry; Jeffrey J Hale; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; George A Doss; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines.
Bioorganic & medicinal chemistry letters 2002;12(4):677-9.
2002: Yuan Cheng; Thomas A Rano; Tracy T Huening; Fengqi Zhang; Zhijian Lu; William A Schleif; Lori Gabryelski; David B Olsen; Mark Stahlhut; Lawrence C Kuo; Jiunn H Lin; Xin Xu; Lixia Jin; Timothy V Olah; Debra McLoughlin; Rick C King; Kevin Chapman; James R Tata
A combinatorial library of indinavir analogues and its in vitro and in vivo studies.
Bioorganic & medicinal chemistry letters 2002;12(4):529-32.
2001: Christopher A Willoughby; Scott Berk; Keith G Rosauer; SJ Degrado; Kevin Chapman; Sandra L Gould; Martin S Springer; Lorraine Malkowitz; William A Schleif; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Karen Holmes; Janet Lineberger; Anthony Carella; Gwen Carver; Emilio A Emini
Combinatorial synthesis of CCR5 antagonists.
Bioorganic & medicinal chemistry letters 2001;11(24):3137-41.
2001: Dooseop Kim; Liping Wang; Charles G Caldwell; Ping Chen; Paul E Finke; Bryan Oates; Malcolm MacCoss; Sander G Mills; Lorraine Malkowitz; Sandra L Gould; Julie A DeMartino; Martin S Springer; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Gwen Carver; Anthony Carella; Karen Holmes; Janet Lineberger; William A Schleif; Emilio A Emini
Design, synthesis, and SAR of heterocycle-containing antagonists of the human CCR5 receptor for the treatment of HIV-1 infection.
Bioorganic & medicinal chemistry letters 2001;11(24):3103-6.
2001: Dooseop Kim; Liping Wang; Charles G Caldwell; Ping Chen; Paul E Finke; Bryan Oates; Malcolm MacCoss; Sander G Mills; Lorraine Malkowitz; Sandra L Gould; Julie A DeMartino; Martin S Springer; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Gwen Carver; Anthony Carella; Karen Holmes; Janet Lineberger; William A Schleif; Emilio A Emini
Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection.
Bioorganic & medicinal chemistry letters 2001;11(24):3099-102.
2001: Jeffrey J Hale; Richard J Budhu; E B Holson; Paul E Finke; Bryan Oates; Sander G Mills; Malcolm MacCoss; Sandra L Gould; Julie A DeMartino; Martin S Springer; Salvatore J Siciliano; Lorraine Malkowitz; William A Schleif; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Karen Holmes; Janet Lineberger; Anthony Carella; Gwen Carver; Emilio A Emini
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent anti-HIV activity.
Bioorganic & medicinal chemistry letters 2001;11(20):2741-5.
2001: Paul E Finke; Bryan Oates; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Anthony Carella; Gwen Carver; Karen Holmes; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; William A Schleif; Emilio A Emini
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure-activity relationships for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes.
Bioorganic & medicinal chemistry letters 2001;11(18):2475-9.
2001: Huldrych Günthard; Diane V Havlir; Susan A Fiscus; Z Q Zhang; Joseph J Eron; John Mellors; Roy M Gulick; Simon D W Frost; A J Brown; William A Schleif; Fred Valentine; L Jonas; Anne R Meibohm; Caroline C Ignacio; Robin Isaacs; R Gamagami; Emilio A Emini; A Haase; Douglas D Richman; Joseph Wong
Residual human immunodeficiency virus (HIV) Type 1 RNA and DNA in lymph nodes and HIV RNA in genital secretions and in cerebrospinal fluid after suppression of viremia for 2 years.
The Journal of infectious diseases 2001;183(9):1318-27.
2001: Paul E Finke; Laura C Meurer; Bryan Oates; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Bruce L Daugherty; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Anthony Carella; Gwen Carver; Karen Holmes; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; William A Schleif; Emilio A Emini
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: structure-activity relationships for substituted 2-Aryl-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes.
Bioorganic & medicinal chemistry letters 2001;11(2):265-70.
2001: C P Dorn; Paul E Finke; Bryan Oates; Richard J Budhu; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Bruce L Daugherty; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Anthony Carella; Gwen Carver; Karen Holmes; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; William A Schleif; Emilio A Emini
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. part 1: discovery and initial structure-activity relationships for 1 -amino-2-phenyl-4-(piperidin-1-yl)butanes.
Bioorganic & medicinal chemistry letters 2001;11(2):259-64.
2000: John S Wai; Melissa S Egbertson; L S Payne; Thorsten E Fisher; Mark W Embrey; L O Tran; Jeffrey Y Melamed; H M Langford; James P Guare; Linghang Zhuang; V E Grey; Joseph P Vacca; M Katharine Holloway; Adel M Naylor-Olsen; Daria J Hazuda; Peter J Felock; Abigail L Wolfe; Kara A Stillmock; William A Schleif; Lori Gabryelski; Steven D Young
4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.
Journal of medicinal chemistry 2000;43(26):4923-6.
2000: Bruce D Dorsey; Colleen McDonough; S L McDaniel; R B Levin; Christina L Newton; J M Hoffman; Paul L Darke; Joan Zugay-Murphy; Emilio A Emini; William A Schleif; David B Olsen; Mark Stahlhut; Carrie A Rutkowski; Lawrence C Kuo; Jiunn H Lin; I-Wu Chen; Stuart R Michelson; M Katharine Holloway; Joel R Huff; Joseph P Vacca
Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors.
Journal of medicinal chemistry 2000;43(18):3386-99.
2000: Jon H Condra; C J Petropoulos; R Ziermann; William A Schleif; Malathi Shivaprakash; Emilio A Emini
Drug resistance and predicted virologic responses to human immunodeficiency virus type 1 protease inhibitor therapy.
The Journal of infectious diseases 2000;182(3):758-65.
2000: Thomas A Rano; Yuan Cheng; T T Huening; Fengqi Zhang; William A Schleif; Lori Gabryelski; David B Olsen; Lawrence C Kuo; Jiunn H Lin; X Xu; Timothy V Olah; Debra McLoughlin; R King; Kevin Chapman; James R Tata
Combinatorial diversification of indinavir: in vivo mixture dosing of an HIV protease inhibitor library.
Bioorganic & medicinal chemistry letters 2000;10(14):1527-30.
2000: Daria J Hazuda; Peter J Felock; Marc V Witmer; Abigail Wolfe; Kara A Stillmock; Jay A Grobler; Amy S Espeseth; Lori Gabryelski; William A Schleif; CU Blau; Michael D Miller
Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells.
Science (New York, N.Y.) 2000;287(5453):646-50.
1998: Roy M Gulick; John W Mellors; Diane V Havlir; Joseph J Eron; Charles Gonzalez; Douglas McMahon; L Jonas; Anne R Meibohm; Daniel J Holder; William A Schleif; Jon H Condra; Emilio A Emini; Robin Isaacs; Jeffrey A Chodakewitz; Douglas D Richman
Simultaneous vs sequential initiation of therapy with indinavir, zidovudine, and lamivudine for HIV-1 infection: 100-week follow-up.
JAMA : the journal of the American Medical Association 1998;280(1):35-41.
1997: Amos B Smith; Ralph Hirschmann; A Pasternak; Wenquin Yao; Paul A Sprengeler; M Katharine Holloway; Lawrence C Kuo; Zhongguo Chen; Paul L Darke; William A Schleif
An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex.
Journal of medicinal chemistry 1997;40(16):2440-4.
1996: Jon H Condra; D J Holder; William A Schleif; O M Blahy; R M Danovich; L J Gabryelski; D J Graham; D Laird; J C Quintero; A Rhodes; H L Robbins; E Roth; M Shivaprakash; T Yang; Jeffrey A Chodakewitz; Paul J Deutsch; R Y Leavitt; F E Massari; J W Mellors; K E Squires; R T Steigbigel; H Teppler; Emilio A Emini
Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor.
Journal of virology 1996;70(12):8270-6.
1996: Anthony J Conley; J A Kessler; L J Boots; PM McKenna; William A Schleif; Emilio A Emini; G E Mark; H Katinger; E K Cobb; S M Lunceford; S R Rouse; Krishna K Murthy
The consequence of passive administration of an anti-human immunodeficiency virus type 1 neutralizing monoclonal antibody before challenge of chimpanzees with a primary virus isolate.
Journal of virology 1996;70(10):6751-8.
1996: Arun K Ghosh; J F Kincaid; Eric Walters; Y Chen; N C Chaudhuri; W J Thompson; C Culberson; P M Fitzgerald; H Y Lee; S P McKee; P M Munson; T T Duong; Paul L Darke; J A Zugay; William A Schleif; M G Axel; J Lin; Joel R Huff
Nonpeptidal P2 ligands for HIV protease inhibitors: structure-based design, synthesis, and biological evaluation.
Journal of medicinal chemistry 1996;39(17):3278-90.
1996: Emilio A Emini; William A Schleif; Paul J Deutsch; Jon H Condra
In vivo selection of HIV-1 variants with reduced susceptibility to the protease inhibitor L-735,524 and related compounds.
Advances in experimental medicine and biology 1996;394():327-31.
1995: Jon H Condra; William A Schleif; O M Blahy; L J Gabryelski; D J Graham; J C Quintero; A Rhodes; H L Robbins; E Roth; M Shivaprakash
In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors.
Nature 1995;374(6522):569-71.
1994: Bruce D Dorsey; R B Levin; S L McDaniel; Joseph P Vacca; James P Guare; Paul L Darke; J A Zugay; Emilio A Emini; William A Schleif; J C Quintero
L-735,524: the design of a potent and orally bioavailable HIV protease inhibitor.
Journal of medicinal chemistry 1994;37(21):3443-51.
1994: V W Byrnes; Emilio A Emini; William A Schleif; Jon H Condra; C L Schneider; W J Long; J A Wolfgang; D J Graham; L Gotlib; A J Schlabach
Susceptibilities of human immunodeficiency virus type 1 enzyme and viral variants expressing multiple resistance-engendering amino acid substitutions to reserve transcriptase inhibitors.
Antimicrobial agents and chemotherapy 1994;38(6):1404-7.
1994: Joseph P Vacca; Bruce D Dorsey; William A Schleif; R B Levin; S L McDaniel; Paul L Darke; J Zugay; J C Quintero; O M Blahy; E Roth
L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):4096-100.
1994: Emilio A Emini; V W Byrnes; Jon H Condra; William A Schleif; Vinod Sardana
The genetic and functional basis of HIV-1 resistance to nonnucleoside reverse transcriptase inhibitors.
Archives of virology. Supplementum 1994;9():11-7.
1994: William A Schleif; Krishna K Murthy; Vinod Sardana; C L Schneider; V W Byrnes; K E Cobb; E Roth; J A Wolfgang; J M Hoffman; A M Smith
Attempted prophylaxis of human immunodeficiency virus type 1 infection in chimpanzees with a nonnucleoside reverse transcriptase inhibitor.
AIDS research and human retroviruses 1994;10(1):107-10.
1993: Michael S Saag; Emilio A Emini; O L Laskin; J Douglas; W I Lapidus; William A Schleif; Richard J Whitley; C Hildebrand; V W Byrnes; John C Kappes
A short-term clinical evaluation of L-697,661, a non-nucleoside inhibitor of HIV-1 reverse transcriptase. L-697,661 Working Group.
The New England journal of medicine 1993;329(15):1065-72.
1993: Emilio A Emini; D J Graham; L Gotlib; Jon H Condra; V W Byrnes; William A Schleif
HIV and multidrug resistance.
Nature 1993;364(6439):679.
1993: V W Byrnes; Vinod Sardana; William A Schleif; Jon H Condra; J A Waterbury; J A Wolfgang; W J Long; C L Schneider; A J Schlabach; B S Wolanski
Comprehensive mutant enzyme and viral variant assessment of human immunodeficiency virus type 1 reverse transcriptase resistance to nonnucleoside inhibitors.
Antimicrobial agents and chemotherapy 1993;37(8):1576-9.
1993: M E Goldman; J A O'Brien; T L Ruffing; William A Schleif; Vinod Sardana; V W Byrnes; Jon H Condra; J M Hoffman; Emilio A Emini
A nonnucleoside reverse transcriptase inhibitor active on human immunodeficiency virus type 1 isolates resistant to related inhibitors.
Antimicrobial agents and chemotherapy 1993;37(5):947-9.
1993: Arun K Ghosh; W J Thompson; H Y Lee; S P McKee; P M Munson; T T Duong; Paul L Darke; J A Zugay; Emilio A Emini; William A Schleif
Cyclic sulfolanes as novel and high affinity P2 ligands for HIV-1 protease inhibitors.
Journal of medicinal chemistry 1993;36(7):924-7.
1993: Arun K Ghosh; W J Thompson; S P McKee; T T Duong; T A Lyle; J C Chen; Paul L Darke; J A Zugay; Emilio A Emini; William A Schleif
3-Tetrahydrofuran and pyran urethanes as high-affinity P2-ligands for HIV-1 protease inhibitors.
Journal of medicinal chemistry 1993;36(2):292-4.
1993: Arun K Ghosh; S P McKee; W M Sanders; Paul L Darke; J A Zugay; Emilio A Emini; William A Schleif; J C Quintero; Joel R Huff; P S Anderson
HIV-1 protease inhibitors: synthesis and biological evaluation of glycopeptidemimetics.
Drug design and discovery 1993;10(1):77-88.
1992: R L LaFemina; C L Schneider; H L Robbins; P L Callahan; K LeGrow; E Roth; William A Schleif; Emilio A Emini
Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells.
Journal of virology 1992;66(12):7414-9.
1992: Thomas J Tucker; William C Lumma; L S Payne; J M Wai; S J de Solms; E A Giuliani; Paul L Darke; J C Heimbach; J A Zugay; William A Schleif
A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity.
Journal of medicinal chemistry 1992;35(14):2525-33.
1992: W J Thompson; P M Fitzgerald; M K Holloway; Emilio A Emini; Paul L Darke; Brian McKeever; William A Schleif; J C Quintero; J A Zugay; Thomas J Tucker
Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl substituents: X-ray crystal structure assisted design.
Journal of medicinal chemistry 1992;35(10):1685-701.
1992: M E Goldman; J A O'Brien; T L Ruffing; J H Nunberg; William A Schleif; J C Quintero; Peter K S Siegl; J M Hoffman; A M Smith; Emilio A Emini
L-696,229 specifically inhibits human immunodeficiency virus type 1 reverse transcriptase and possesses antiviral activity in vitro.
Antimicrobial agents and chemotherapy 1992;36(5):1019-23.
1992: Emilio A Emini; William A Schleif; J H Nunberg; Anthony J Conley; Yasuyuki Eda; Sachio Tokiyoshi; S D Putney; Shuzo Matsushita; K E Cobb; C M Jett
Prevention of HIV-1 infection in chimpanzees by gp120 V3 domain-specific monoclonal antibody.
Nature 1992;355(6362):728-30.
1991: J H Nunberg; William A Schleif; E J Boots; J A O'Brien; J C Quintero; J M Hoffman; Emilio A Emini; M E Goldman
Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors.
Journal of virology 1991;65(9):4887-92.
1991: M E Goldman; J H Nunberg; J A O'Brien; J C Quintero; William A Schleif; K F Freund; Stanley L Gaul; W S Saari; J S Wai; J M Hoffman
Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(15):6863-7.
1991: T A Lyle; C M Wiscount; James P Guare; W J Thompson; P S Anderson; Paul L Darke; Z A Zugay; Emilio A Emini; William A Schleif; J C Qunitero
Benzocycloalkyl amines as novel C-termini for HIV protease inhibitors.
Journal of medicinal chemistry 1991;34(3):1228-30.
1991: Joseph P Vacca; James P Guare; S Jane deSolms; W M Sanders; E A Giuliani; S D Young; Paul L Darke; J Zugay; I S Sigal; William A Schleif
L-687,908, a potent hydroxyethylene-containing HIV protease inhibitor.
Journal of medicinal chemistry 1991;34(3):1225-8.
1990: Emilio A Emini; William A Schleif; J C Quintero; P G Conard; J W Eichberg; G P Vlasuk; ED Lehman; M A Polokoff; T F Schaeffer; Loren D Schultz
Yeast-expressed p55 precursor core protein of human immunodeficiency virus type 1 does not elicit protective immunity in chimpanzees.
AIDS research and human retroviruses 1990;6(11):1247-50.
1990: Emilio A Emini; P L Nara; William A Schleif; J A Lewis; J P Davide; D R Lee; J Kessler; S Conley; Shuzo Matsushita; S D Putney
Antibody-mediated in vitro neutralization of human immunodeficiency virus type 1 abolishes infectivity for chimpanzees.
Journal of virology 1990;64(8):3674-8.
1990: M E Goldman; G S Salituro; J A Bowen; J M Williamson; D L Zink; William A Schleif; Emilio A Emini
Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: competitive interaction at the template.primer site.
Molecular pharmacology 1990;38(1):20-5.
1989: Emilio A Emini; William A Schleif; M Silberklang; D Lehman; R W Ellis
Vero cell-expressed Epstein-Barr virus (EBV) gp350/220 protects marmosets from EBV challenge.
Journal of medical virology 1989;27(2):120-3.
1988: Emilio A Emini; William A Schleif; M E Armstrong; M Silberklang; Loren D Schultz; D Lehman; R Z Maigetter; L F Qualtiere; G R Pearson; R W Ellis
Antigenic analysis of the Epstein-Barr virus major membrane antigen (gp350/220) expressed in yeast and mammalian cells: implications for the development of a subunit vaccine.
Virology 1988;166(2):387-93.
1988: Nancy E Kohl; Emilio A Emini; William A Schleif; L J Davis; J C Heimbach; R A Dixon; E M Scolnick; I S Sigal
Active human immunodeficiency virus protease is required for viral infectivity.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(13):4686-90.
1988: G A Robertson; B M Kostek; William A Schleif; J A Lewis; Emilio A Emini
A microtiter cell-culture assay for the determination of anti-human immunodeficiency virus neutralizing antibody activity.
Journal of virological methods 1988;20(3):195-202.
1986: R L Crowell; A K Field; William A Schleif; W L Long; R J Colonno; J E Mapoles; Emilio A Emini
Monoclonal antibody that inhibits infection of HeLa and rhabdomyosarcoma cells by selected enteroviruses through receptor blockade.
Journal of virology 1986;57(2):438-45.
1985: Emilio A Emini; William A Schleif; B A Jameson; E Wimmer
The immune response to poliovirus-specific synthetic peptides: effects of adjuvants and test animal species.
Journal of virological methods 1985;10(2):163-70.
1985: Emilio A Emini; William A Schleif; R J Colonno; E Wimmer
Antigenic conservation and divergence between the viral-specific proteins of poliovirus type 1 and various picornaviruses.
Virology 1985;140(1):13-20.