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Joseph Schlessinger

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Bae Jae Hyun; Lew Erin Denise; Yuzawa Satoru; Tomé Francisco; Lax Irit; Schlessinger Joseph
The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.
Margulies David; Opatowsky Yarden; Fletcher Steven; Saraogi Ishu; Tsou Lun K; Saha Sourav; Lax Irit; Schlessinger Joseph; Hamilton Andrew D
Surface binding inhibitors of the SCF-KIT protein-protein interaction.
Lulo James; Yuzawa Satoru; Schlessinger Joseph
Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2.

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All Publications

2009: Bae Jae Hyun; Lew Erin Denise; Yuzawa Satoru; Tomé Francisco; Lax Irit; Schlessinger Joseph
The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.
Cell 2009;138(3):514-24.
2009: Margulies David; Opatowsky Yarden; Fletcher Steven; Saraogi Ishu; Tsou Lun K; Saha Sourav; Lax Irit; Schlessinger Joseph; Hamilton Andrew D
Surface binding inhibitors of the SCF-KIT protein-protein interaction.
Chembiochem : a European journal of chemical biology 2009;10(12):1955-8.
2009: Lulo James; Yuzawa Satoru; Schlessinger Joseph
Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2.
Biochemical and biophysical research communications 2009;383(3):347-52.
2009: Lew Erin D; Furdui Cristina M; Anderson Karen S; Schlessinger Joseph
The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations.
Science signaling 2009;2(58):ra6.
2008: Yang Yan; Yuzawa Satoru; Schlessinger Joseph
Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(22):7681-6.
2008: Yuzawa Satornu; Schlessinger Joseph
[Structural biology of receptor tyrosine kinase kit]
Seikagaku. The Journal of Japanese Biochemical Society 2008;80(2):94-104.
2008: Wang Lu; Tassiulas Ioannis; Park-Min Kyung-Hyun; Reid Alicia C; Gil-Henn Hava; Schlessinger Joseph; Baron Roland; Zhang J Jillian; Ivashkiv Lionel B
'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages.
Nature immunology 2008;9(2):186-93.
2007: Lew Erin D; Bae Jae Hyun; Rohmann Edyta; Wollnik Bernd; Schlessinger Joseph
Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):19802-7.
2007: Shams Imad; Rohmann Edyta; Eswarakumar Veraragavan P; Lew Erin D; Yuzawa Satoru; Wollnik Bernd; Schlessinger Joseph; Lax Irit
Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway.
Molecular and cellular biology 2007;27(19):6903-12.
2007: Gil-Henn Hava; Destaing Olivier; Sims Natalie A; Aoki Kazuhiro; Alles Neil; Neff Lynn; Sanjay Archana; Bruzzaniti Angela; De Camilli Pietro; Baron Roland; Schlessinger Joseph
Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice.
The Journal of cell biology 2007;178(6):1053-64.
2007: Yuzawa Satoru; Opatowsky Yarden; Zhang Zhongtao; Mandiyan Valsan; Lax Irit; Schlessinger Joseph
Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor.
Cell 2007;130(2):323-34.
2007: Eswarakumar Veraragavan P; Schlessinger Joseph
Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3937-42.
2006: Eswarakumar V P; Ozcan F; Lew E D; Bae J H; Tomé F; Booth C J; Adams D J; Lax I; Schlessinger J
Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(49):18603-8.
2006: Schlessinger Joseph; Lemmon Mark A
Nuclear signaling by receptor tyrosine kinases: the first robin of spring.
Cell 2006;127(1):45-8.
2006: Lamprianou Smaragda; Vacaresse Nathalie; Suzuki Yoshihisa; Meziane Hamid; Buxbaum Joseph D; Schlessinger Joseph; Harroch Sheila
Receptor protein tyrosine phosphatase gamma is a marker for pyramidal cells and sensory neurons in the nervous system and is not necessary for normal development.
Molecular and cellular biology 2006;26(13):5106-19.
2006: Galisteo Maria L; Yang Yan; Ureña Jesus; Schlessinger Joseph
Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(26):9796-801.
2006: Ozcan Ferruh; Klein Peter; Lemmon Mark A; Lax Irit; Schlessinger Joseph
On the nature of low- and high-affinity EGF receptors on living cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5735-40.
2006: Rohmann Edyta; Brunner Han G; Kayserili Hülya; Uyguner Oya; Nürnberg Gudrun; Lew Erin D; Dobbie Angus; Eswarakumar Veraragavan P; Uzumcu Abdullah; Ulubil-Emeroglu Melike; Leroy Jules G; Li Yun; Becker Christian; Lehnerdt Kai; Cremers Cor W R J; Yüksel-Apak Memnune; Nürnberg Peter; Kubisch Christian; Schlessinger Joseph; van Bokhoven Hans; Wollnik Bernd
Mutations in different components of FGF signaling in LADD syndrome.
Nature genetics 2006;38(4):414-7.
2006: Furdui Cristina M; Lew Erin D; Schlessinger Joseph; Anderson Karen S
Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction.
Molecular cell 2006;21(5):711-7.
2005: Yamamoto S; Yoshino I; Shimazaki T; Murohashi M; Hevner R F; Lax I; Okano H; Shibuya M; Schlessinger J; Gotoh N
Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):15983-8.
2005: Gotoh N; Manova K; Tanaka S; Murohashi M; Hadari Y; Lee A; Hamada Y; Hiroe T; Ito M; Kurihara T; Nakazato H; Shibuya M; Lax I; Lacy E; Schlessinger J
The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development.
Molecular and cellular biology 2005;25(10):4105-16.
2005: Eswarakumar V P; Lax I; Schlessinger J
Cellular signaling by fibroblast growth factor receptors.
Cytokine & growth factor reviews 2005;16(2):139-49.
2004: Gotoh N; Ito M; Yamamoto S; Yoshino I; Song N; Wang Y; Lax I; Schlessinger J; Shibuya M; Lang R A
Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(49):17144-9.
2004: Schlessinger Joseph
Common and distinct elements in cellular signaling via EGF and FGF receptors.
Science (New York, N.Y.) 2004;306(5701):1506-7.
2004: Lamothe Betty; Yamada Masashi; Schaeper Ute; Birchmeier Walter; Lax Irit; Schlessinger Joseph
The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway.
Molecular and cellular biology 2004;24(13):5657-66.
2004: Gotoh Noriko; Laks Shaked; Nakashima Misako; Lax Irit; Schlessinger Joseph
FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts.
FEBS letters 2004;564(1-2):14-8.
2004: Klein Peter; Mattoon Dawn; Lemmon Mark A; Schlessinger Joseph
A structure-based model for ligand binding and dimerization of EGF receptors.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(4):929-34.
2004: Mattoon Dawn; Klein Peter; Lemmon Mark A; Lax Irit; Schlessinger Joseph
The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(4):923-8.
2004: Olsen Shaun K; Ibrahimi Omar A; Raucci Angela; Zhang Fuming; Eliseenkova Anna V; Yayon Avner; Basilico Claudio; Linhardt Robert J; Schlessinger Joseph; Mohammadi Moosa
Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(4):935-40.
2004: Mattoon Dawn R; Lamothe Betty; Lax Irit; Schlessinger Joseph
The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway.
BMC biology 2004;2():24.
2003: Okigaki M; Davis C; Falasca M; Harroch S; Felsenfeld D P; Sheetz M P; Schlessinger J
Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10740-5.
2003: Schlessinger Joseph; Lemmon Mark A
SH2 and PTB domains in tyrosine kinase signaling.
Science's STKE : signal transduction knowledge environment 2003;2003(191):RE12.
2003: Schlessinger Joseph
Signal transduction. Autoinhibition control.
Science (New York, N.Y.) 2003;300(5620):750-2.
2002: Harroch Sheila; Furtado Glaucia C; Brueck Wolfgang; Rosenbluth Jack; Lafaille Juan; Chao Moses; Buxbaum Joseph D; Schlessinger Joseph
A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions.
Nature genetics 2002;32(3):411-4.
2002: Lax Irit; Wong Andy; Lamothe Betty; Lee Arnold; Frost Adam; Hawes Jessica; Schlessinger Joseph
The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors.
Molecular cell 2002;10(4):709-19.
2002: Schlessinger Joseph
Ligand-induced, receptor-mediated dimerization and activation of EGF receptor.
Cell 2002;110(6):669-72.
2002: Schlessinger Joseph
All signaling is local?
Molecular cell 2002;10(2):218-9.
2002: Wong Andy; Lamothe Betty; Lee Arnold; Schlessinger Joseph; Lax Irit;
FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6684-9.
2002: Schlessinger Joseph
A solid base for assaying protein kinase activity.
Nature biotechnology 2002;20(3):232-3.
2001: Hadari Y R; Gotoh N; Kouhara H; Lax I; Schlessinger J
Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8578-83.
2001: Melillo R M; Santoro M; Ong S H; Billaud M; Fusco A; Hadari Y R; Schlessinger J; Lax I
Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade.
Molecular and cellular biology 2001;21(13):4177-87.
2001: Nishida M; Nagata K; Hachimori Y; Horiuchi M; Ogura K; Mandiyan V; Schlessinger J; Inagaki F
Novel recognition mode between Vav and Grb2 SH3 domains.
The EMBO journal 2001;20(12):2995-3007.
2001: Andreev J; Galisteo M L; Kranenburg O; Logan S K; Chiu E S; Okigaki M; Cary L A; Moolenaar W H; Schlessinger J
Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade.
The Journal of biological chemistry 2001;276(23):20130-5.
2001: Ong S H; Hadari Y R; Gotoh N; Guy G R; Schlessinger J; Lax I
Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6074-9.
2001: Yuzawa S; Yokochi M; Hatanaka H; Ogura K; Kataoka M; Miura K; Mandiyan V; Schlessinger J; Inagaki F
Solution structure of Grb2 reveals extensive flexibility necessary for target recognition.
Journal of molecular biology 2001;306(3):527-37.
2000: Schlessinger J
Cell signaling by receptor tyrosine kinases.
Cell 2000;103(2):211-25.
2000: Harroch S; Palmeri M; Rosenbluth J; Custer A; Okigaki M; Shrager P; Blum M; Buxbaum J D; Schlessinger J
No obvious abnormality in mice deficient in receptor protein tyrosine phosphatase beta.
Molecular and cellular biology 2000;20(20):7706-15.
2000: Schlessinger J; Plotnikov A N; Ibrahimi O A; Eliseenkova A V; Yeh B K; Yayon A; Linhardt R J; Mohammadi M
Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.
Molecular cell 2000;6(3):743-50.
2000: Zhang Z; Zhang R; Joachimiak A; Schlessinger J; Kong X P
Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):7732-7.
2000: Plotnikov A N; Hubbard S R; Schlessinger J; Mohammadi M
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Cell 2000;101(4):413-24.
2000: Schlessinger J
New roles for Src kinases in control of cell survival and angiogenesis.
Cell 2000;100(3):293-6.
2000: Rodrigues G A; Falasca M; Zhang Z; Ong S H; Schlessinger J
A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling.
Molecular and cellular biology 2000;20(4):1448-59.
2000: Ong S H; Guy G R; Hadari Y R; Laks S; Gotoh N; Schlessinger J; Lax I
FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors.
Molecular and cellular biology 2000;20(3):979-89.
1999: Mandiyan V; Andreev J; Schlessinger J; Hubbard S R
Crystal structure of the ARF-GAP domain and ankyrin repeats of PYK2-associated protein beta.
The EMBO journal 1999;18(24):6890-8.
1999: Plotnikov A N; Schlessinger J; Hubbard S R; Mohammadi M
Structural basis for FGF receptor dimerization and activation.
Cell 1999;98(5):641-50.
1999: Ogura K; Tsuchiya S; Terasawa H; Yuzawa S; Hatanaka H; Mandiyan V; Schlessinger J; Inagaki F
Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide.
Journal of molecular biology 1999;289(3):439-45.
1999: Tsuchiya S; Ogura K; Hatanaka H; Nagata K; Terasawa H; Mandiyan V; Schlessinger J; Aimoto S; Ohta H; Inagaki F
Solution structure of the SH2 domain of Grb2/Ash complexed with EGF receptor-derived phosphotyrosine-containing peptide.
Journal of biochemistry 1999;125(6):1151-9.
1999: Takaoka A; Tanaka N; Mitani Y; Miyazaki T; Fujii H; Sato M; Kovarik P; Decker T; Schlessinger J; Taniguchi T
Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling.
The EMBO journal 1999;18(9):2480-8.
1999: Andreev J; Simon J P; Sabatini D D; Kam J; Plowman G; Randazzo P A; Schlessinger J
Identification of a new Pyk2 target protein with Arf-GAP activity.
Molecular and cellular biology 1999;19(3):2338-50.
1999: Lev S; Hernandez J; Martinez R; Chen A; Plowman G; Schlessinger J
Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein.
Molecular and cellular biology 1999;19(3):2278-88.
1999: Ogura K; Nagata K; Hatanaka H; Habuchi H; Kimata K; Tate S; Ravera M W; Jaye M; Schlessinger J; Inagaki F
Solution structure of human acidic fibroblast growth factor and interaction with heparin-derived hexasaccharide.
Journal of biomolecular NMR 1999;13(1):11-24.
1998: Moreno H; Nadal M; Leznik E; Sugimori M; Lax I; Schlessinger J; Llinás R
Nerve growth factor acutely reduces chemical transmission by means of postsynaptic TrkA-like receptors in squid giant synapse.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14997-5002.
1998: Mohammadi M; Froum S; Hamby J M; Schroeder M C; Panek R L; Lu G H; Eliseenkova A V; Green D; Schlessinger J; Hubbard S R
Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.
The EMBO journal 1998;17(20):5896-904.
1998: Hadari Y R; Kouhara H; Lax I; Schlessinger J
Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation.
Molecular and cellular biology 1998;18(7):3966-73.
1998: Hubbard S R; Mohammadi M; Schlessinger J
Autoregulatory mechanisms in protein-tyrosine kinases.
The Journal of biological chemistry 1998;273(20):11987-90.
1998: Miyazaki T; Takaoka A; Nogueira L; Dikic I; Fujii H; Tsujino S; Mitani Y; Maeda M; Schlessinger J; Taniguchi T
Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway.
Genes & development 1998;12(6):770-5.
1998: Falasca M; Logan S K; Lehto V P; Baccante G; Lemmon M A; Schlessinger J
Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.
The EMBO journal 1998;17(2):414-22.
1997: Schlessinger J
Direct binding and activation of receptor tyrosine kinases by collagen.
Cell 1997;91(7):869-72.
1997: Ogura K; Tsuchiya S; Terasawa H; Yuzawa S; Hatanaka H; Mandiyan V; Schlessinger J; Inagaki F
Conformation of an Shc-derived phosphotyrosine-containing peptide complexed with the Grb2 SH2 domain.
Journal of biomolecular NMR 1997;10(3):273-8.
1997: Zhang Z; Lee C H; Mandiyan V; Borg J P; Margolis B; Schlessinger J; Kuriyan J
Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.
The EMBO journal 1997;16(20):6141-50.
1997: Logan S K; Falasca M; Hu P; Schlessinger J
Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway.
Molecular and cellular biology 1997;17(10):5784-90.
1997: Rodrigues G A; Park M; Schlessinger J
Activation of the JNK pathway is essential for transformation by the Met oncogene.
The EMBO journal 1997;16(10):2634-45.
1997: Kouhara H; Hadari Y R; Spivak-Kroizman T; Schilling J; Bar-Sagi D; Lax I; Schlessinger J
A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway.
Cell 1997;89(5):693-702.
1997: Mohammadi M; McMahon G; Sun L; Tang C; Hirth P; Yeh B K; Hubbard S R; Schlessinger J
Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
Science (New York, N.Y.) 1997;276(5314):955-60.
1997: Schlessinger J
Phospholipase Cgamma activation and phosphoinositide hydrolysis are essential for embryonal development.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):2798-9.
1997: Peles E; Nativ M; Lustig M; Grumet M; Schilling J; Martinez R; Plowman G D; Schlessinger J
Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions.
The EMBO journal 1997;16(5):978-88.
1997: Llinás R; Moreno H; Sugimori M; Mohammadi M; Schlessinger J
Differential pre- and postsynaptic modulation of chemical transmission in the squid giant synapse by tyrosine phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1990-4.
1997: Lemmon M A; Pinchasi D; Zhou M; Lax I; Schlessinger J
Kit receptor dimerization is driven by bivalent binding of stem cell factor.
The Journal of biological chemistry 1997;272(10):6311-7.
1997: Sakurai T; Lustig M; Nativ M; Hemperly J J; Schlessinger J; Peles E; Grumet M
Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta.
The Journal of cell biology 1997;136(4):907-18.
1997: Lemmon M A; Bu Z; Ladbury J E; Zhou M; Pinchasi D; Lax I; Engelman D M; Schlessinger J
Two EGF molecules contribute additively to stabilization of the EGFR dimer.
The EMBO journal 1997;16(2):281-94.
1996: Sahni M; Zhou X M; Bakiri L; Schlessinger J; Baron R; Levy J B
Identification of a novel 135-kDa Grb2-binding protein in osteoclasts.
The Journal of biological chemistry 1996;271(51):33141-7.
1996: Roghani M; Mohammadi M; Schlessinger J; Moscatelli D
Induction of urokinase-type plasminogen activator by fibroblast growth factor (FGF)-2 is dependent on expression of FGF receptors and does not require activation of phospholipase Cgamma1.
The Journal of biological chemistry 1996;271(49):31154-9.
1996: Dikic I; Tokiwa G; Lev S; Courtneidge S A; Schlessinger J
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation.
Nature 1996;383(6600):547-50.
1996: Galisteo M L; Chernoff J; Su Y C; Skolnik E Y; Schlessinger J
The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1.
The Journal of biological chemistry 1996;271(35):20997-1000.
1996: Mohammadi M; Schlessinger J; Hubbard S R
Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism.
Cell 1996;86(4):577-87.
1996: Tokiwa G; Dikic I; Lev S; Schlessinger J
Activation of Pyk2 by stress signals and coupling with JNK signaling pathway.
Science (New York, N.Y.) 1996;273(5276):792-4.
1996: Canoll P D; Petanceska S; Schlessinger J; Musacchio J M
Three forms of RPTP-beta are differentially expressed during gliogenesis in the developing rat brain and during glial cell differentiation in culture.
Journal of neuroscience research 1996;44(3):199-215.
1996: Lemmon M A; Ferguson K M; Schlessinger J
PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface.
Cell 1996;85(5):621-4.
1996: Mohammadi M; Dikic I; Sorokin A; Burgess W H; Jaye M; Schlessinger J
Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction.
Molecular and cellular biology 1996;16(3):977-89.
1996: Mandiyan V; O'Brien R; Zhou M; Margolis B; Lemmon M A; Sturtevant J M; Schlessinger J
Thermodynamic studies of SHC phosphotyrosine interaction domain recognition of the NPXpY motif.
The Journal of biological chemistry 1996;271(9):4770-5.
1995: Ferguson K M; Lemmon M A; Schlessinger J; Sigler P B
Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain.
Cell 1995;83(6):1037-46.
1995: Schlessinger J; Lax I; Lemmon M
Regulation of growth factor activation by proteoglycans: what is the role of the low affinity receptors?
Cell 1995;83(3):357-60.
1995: Lemmon M A; Ferguson K M; O'Brien R; Sigler P B; Schlessinger J
Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(23):10472-6.
1995: Galisteo M L; Dikic I; Batzer A G; Langdon W Y; Schlessinger J
Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation.
The Journal of biological chemistry 1995;270(35):20242-5.
1995: Mainiero F; Pepe A; Wary K K; Spinardi L; Mohammadi M; Schlessinger J; Giancotti F G
Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes.
The EMBO journal 1995;14(18):4470-81.
1995: Ferguson K M; Lemmon M A; Sigler P B; Schlessinger J
Scratching the surface with the PH domain.
Nature structural biology 1995;2(9):715-8.
1995: Lev S; Moreno H; Martinez R; Canoll P; Peles E; Musacchio J M; Plowman G D; Rudy B; Schlessinger J
Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions.
Nature 1995;376(6543):737-45.
1995: Batzer A G; Blaikie P; Nelson K; Schlessinger J; Margolis B
The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor.
Molecular and cellular biology 1995;15(8):4403-9.
1995: Fernandez R; Tabarini D; Azpiazu N; Frasch M; Schlessinger J
The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential.
The EMBO journal 1995;14(14):3373-84.
1995: Peles E; Nativ M; Campbell P L; Sakurai T; Martinez R; Lev S; Clary D O; Schilling J; Barnea G; Plowman G D; Grumet M; Schlessinger J
The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin.
Cell 1995;82(2):251-60.
1995: Wang H; Yan H; Canoll P D; Silvennoinen O; Schlessinger J; Musacchio J M
Expression of receptor protein tyrosine phosphatase-sigma (RPTP-sigma) in the nervous system of the developing and adult rat.
Journal of neuroscience research 1995;41(3):297-310.
1995: Dikic I; Batzer A G; Blaikie P; Obermeier A; Ullrich A; Schlessinger J; Margolis B
Shc binding to nerve growth factor receptor is mediated by the phosphotyrosine interaction domain.
The Journal of biological chemistry 1995;270(25):15125-9.
1995: Ladbury J E; Lemmon M A; Zhou M; Green J; Botfield M C; Schlessinger J
Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3199-203.
1995: Huang J; Mohammadi M; Rodrigues G A; Schlessinger J
Reduced activation of RAF-1 and MAP kinase by a fibroblast growth factor receptor mutant deficient in stimulation of phosphatidylinositol hydrolysis.
The Journal of biological chemistry 1995;270(10):5065-72.
1995: Songyang Z; Carraway K L; Eck M J; Harrison S C; Feldman R A; Mohammadi M; Schlessinger J; Hubbard S R; Smith D P; Eng C
Catalytic specificity of protein-tyrosine kinases is critical for selective signalling.
Nature 1995;373(6514):536-9.
1994: Li N; Schlessinger J; Margolis B
Autophosphorylation mutants of the EGF-receptor signal through auxiliary mechanisms involving SH2 domain proteins.
Oncogene 1994;9(12):3457-65.
1994: Terasawa H; Kohda D; Hatanaka H; Tsuchiya S; Ogura K; Nagata K; Ishii S; Mandiyan V; Ullrich A; Schlessinger J
Structure of the N-terminal SH3 domain of GRB2 complexed with a peptide from the guanine nucleotide releasing factor Sos.
Nature structural biology 1994;1(12):891-7.
1994: Spivak-Kroizman T; Lemmon M A; Dikic I; Ladbury J E; Pinchasi D; Huang J; Jaye M; Crumley G; Schlessinger J; Lax I
Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation.
Cell 1994;79(6):1015-24.
1994: Lemmon M A; Ladbury J E; Mandiyan V; Zhou M; Schlessinger J
Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2.
The Journal of biological chemistry 1994;269(50):31653-8.
1994: Kohda D; Terasawa H; Ichikawa S; Ogura K; Hatanaka H; Mandiyan V; Ullrich A; Schlessinger J; Inagaki F
Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2.
Structure (London, England : 1993) 1994;2(11):1029-40.
1994: Lemmon M A; Schlessinger J
Regulation of signal transduction and signal diversity by receptor oligomerization.
Trends in biochemical sciences 1994;19(11):459-63.
1994: Ferguson K M; Lemmon M A; Schlessinger J; Sigler P B
Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin.
Cell 1994;79(2):199-209.
1994: Desai D M; Sap J; Silvennoinen O; Schlessinger J; Weiss A
The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation.
The EMBO journal 1994;13(17):4002-10.
1994: Dikic I; Schlessinger J; Lax I
PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation.
Current biology : CB 1994;4(8):702-8.
1994: Batzer A G; Rotin D; Ureña J M; Skolnik E Y; Schlessinger J
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.
Molecular and cellular biology 1994;14(8):5192-201.
1994: McPherson P S; Czernik A J; Chilcote T J; Onofri F; Benfenati F; Greengard P; Schlessinger J; De Camilli P
Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(14):6486-90.
1994: Sieh M; Batzer A; Schlessinger J; Weiss A
GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation.
Molecular and cellular biology 1994;14(7):4435-42.
1994: Sorokin A; Mohammadi M; Huang J; Schlessinger J
Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766.
The Journal of biological chemistry 1994;269(25):17056-61.
1994: Spivak-Kroizman T; Mohammadi M; Hu P; Jaye M; Schlessinger J; Lax I
Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells.
The Journal of biological chemistry 1994;269(20):14419-23.
1994: Barnea G; Grumet M; Milev P; Silvennoinen O; Levy J B; Sap J; Schlessinger J
Receptor tyrosine phosphatase beta is expressed in the form of proteoglycan and binds to the extracellular matrix protein tenascin.
The Journal of biological chemistry 1994;269(20):14349-52.
1994: Sorokin A; Lemmon M A; Ullrich A; Schlessinger J
Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond.
The Journal of biological chemistry 1994;269(13):9752-9.
1994: Hu P; Schlessinger J
Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta.
Molecular and cellular biology 1994;14(4):2577-83.
1994: Schlessinger J
SH2/SH3 signaling proteins.
Current opinion in genetics & development 1994;4(1):25-30.
1994: Barnea G; Grumet M; Sap J; Margolis R U; Schlessinger J
Close similarity between receptor-linked tyrosine phosphatase and rat brain proteoglycan.
Cell 1994;76(2):205.
1994: Li W; Nishimura R; Kashishian A; Batzer A G; Kim W J; Cooper J A; Schlessinger J
A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase.
Molecular and cellular biology 1994;14(1):509-17.
1994: Sap J; Jiang Y P; Friedlander D; Grumet M; Schlessinger J
Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding.
Molecular and cellular biology 1994;14(1):1-9.
1994: Schlessinger J; Bar-Sagi D
Activation of Ras and other signaling pathways by receptor tyrosine kinases.
Cold Spring Harbor symposia on quantitative biology 1994;59():173-9.
1993: Lee C H; Li W; Nishimura R; Zhou M; Batzer A G; Myers M G; White M F; Schlessinger J; Skolnik E Y
Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11713-7.
1993: Hu P; Mondino A; Skolnik E Y; Schlessinger J
Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85.
Molecular and cellular biology 1993;13(12):7677-88.
1993: Stern M J; Marengere L E; Daly R J; Lowenstein E J; Kokel M; Batzer A; Olivier P; Pawson T; Schlessinger J
The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.
Molecular biology of the cell 1993;4(11):1175-88.
1993: Yan H; Grossman A; Wang H; D'Eustachio P; Mossie K; Musacchio J M; Silvennoinen O; Schlessinger J
A novel receptor tyrosine phosphatase-sigma that is highly expressed in the nervous system.
The Journal of biological chemistry 1993;268(33):24880-6.
1993: Nishimura R; Li W; Kashishian A; Mondino A; Zhou M; Cooper J; Schlessinger J
Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.
Molecular and cellular biology 1993;13(11):6889-96.
1993: Canoll P D; Barnea G; Levy J B; Sap J; Ehrlich M; Silvennoinen O; Schlessinger J; Musacchio J M
The expression of a novel receptor-type tyrosine phosphatase suggests a role in morphogenesis and plasticity of the nervous system.
Brain research. Developmental brain research 1993;75(2):293-8.
1993: Silvennoinen O; Schindler C; Schlessinger J; Levy D E
Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation.
Science (New York, N.Y.) 1993;261(5129):1736-9.
1993: Chen L L; Gansbacher B; Gilboa E; Taetle R; Oval J; Hibbs M S; Huang C K; Clawson M L; Bilgrami S; Schlessinger J
Retroviral gene transfer of epidermal growth factor receptor into HL60 cells results in a partial block of retinoic acid-induced granulocytic differentiation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(9):769-76.
1993: Vietor I; Schwenger P; Li W; Schlessinger J; Vilcek J
Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein (MAP) kinase in human fibroblasts.
The Journal of biological chemistry 1993;268(25):18994-9.
1993: Mohammadi M; Honegger A; Sorokin A; Ullrich A; Schlessinger J; Hurwitz D R
Aggregation-induced activation of the epidermal growth factor receptor protein tyrosine kinase.
Biochemistry 1993;32(34):8742-8.
1993: Zhou M; Felder S; Rubinstein M; Hurwitz D R; Ullrich A; Lax I; Schlessinger J
Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activation.
Biochemistry 1993;32(32):8193-8.
1993: Schlessinger J
How receptor tyrosine kinases activate Ras.
Trends in biochemical sciences 1993;18(8):273-5.
1993: Bar-Sagi D; Rotin D; Batzer A; Mandiyan V; Schlessinger J
SH3 domains direct cellular localization of signaling molecules.
Cell 1993;74(1):83-91.
1993: Skolnik E Y; Batzer A; Li N; Lee C H; Lowenstein E; Mohammadi M; Margolis B; Schlessinger J
The function of GRB2 in linking the insulin receptor to Ras signaling pathways.
Science (New York, N.Y.) 1993;260(5116):1953-5.
1993: Desai D M; Sap J; Schlessinger J; Weiss A
Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase.
Cell 1993;73(3):541-54.
1993: Li N; Batzer A; Daly R; Yajnik V; Skolnik E; Chardin P; Bar-Sagi D; Margolis B; Schlessinger J
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.
Nature 1993;363(6424):85-8.
1993: Jiang Y P; Wang H; D'Eustachio P; Musacchio J M; Schlessinger J; Sap J
Cloning and characterization of R-PTP-kappa, a new member of the receptor protein tyrosine phosphatase family with a proteolytically cleaved cellular adhesion molecule-like extracellular region.
Molecular and cellular biology 1993;13(5):2942-51.
1993: Gale N W; Kaplan S; Lowenstein E J; Schlessinger J; Bar-Sagi D
Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras.
Nature 1993;363(6424):88-92.
1993: Hu P; Margolis B; Schlessinger J
Vav: a potential link between tyrosine kinases and ras-like GTPases in hematopoietic cell signaling.
BioEssays : news and reviews in molecular, cellular and developmental biology 1993;15(3):179-83.
1993: Kohda D; Hatanaka H; Odaka M; Mandiyan V; Ullrich A; Schlessinger J; Inagaki F
Solution structure of the SH3 domain of phospholipase C-gamma.
Cell 1993;72(6):953-60.
1993: Felder S; Zhou M; Hu P; Ureña J; Ullrich A; Chaudhuri M; White M; Shoelson S E; Schlessinger J
SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange.
Molecular and cellular biology 1993;13(3):1449-55.
1993: Kohda D; Odaka M; Lax I; Kawasaki H; Suzuki K; Ullrich A; Schlessinger J; Inagaki F
A 40-kDa epidermal growth factor/transforming growth factor alpha-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor.
The Journal of biological chemistry 1993;268(3):1976-81.
1993: Futter C E; Felder S; Schlessinger J; Ullrich A; Hopkins C R
Annexin I is phosphorylated in the multivesicular body during the processing of the epidermal growth factor receptor.
The Journal of cell biology 1993;120(1):77-83.
1993: Schlessinger J
Cellular signaling by receptor tyrosine kinases.
Harvey lectures 1993;89():105-23.
1992: Li W; Hu P; Skolnik E Y; Ullrich A; Schlessinger J
The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors.
Molecular and cellular biology 1992;12(12):5824-33.
1992: Margolis B; Silvennoinen O; Comoglio F; Roonprapunt C; Skolnik E; Ullrich A; Schlessinger J
High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):8894-8.
1992: Mohammadi M; Dionne C A; Li W; Li N; Spivak T; Honegger A M; Jaye M; Schlessinger J
Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis.
Nature 1992;358(6388):681-4.
1992: Lowenstein E J; Daly R J; Batzer A G; Li W; Margolis B; Lammers R; Ullrich A; Skolnik E Y; Bar-Sagi D; Schlessinger J
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.
Cell 1992;70(3):431-42.
1992: Li W; Deanin G G; Margolis B; Schlessinger J; Oliver J M
Fc epsilon R1-mediated tyrosine phosphorylation of multiple proteins, including phospholipase C gamma 1 and the receptor beta gamma 2 complex, in RBL-2H3 rat basophilic leukemia cells.
Molecular and cellular biology 1992;12(7):3176-82.
1992: Rotin D; Honegger A M; Margolis B L; Ullrich A; Schlessinger J
Presence of SH2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor.
The Journal of biological chemistry 1992;267(14):9678-83.
1992: Spivak-Kroizman T; Rotin D; Pinchasi D; Ullrich A; Schlessinger J; Lax I
Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses.
The Journal of biological chemistry 1992;267(12):8056-63.
1992: Margolis B; Hu P; Katzav S; Li W; Oliver J M; Ullrich A; Weiss A; Schlessinger J
Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs.
Nature 1992;356(6364):71-4.
1992: Hu P; Margolis B; Skolnik E Y; Lammers R; Ullrich A; Schlessinger J
Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors.
Molecular and cellular biology 1992;12(3):981-90.
1992: Rotin D; Margolis B; Mohammadi M; Daly R J; Daum G; Li N; Fischer E H; Burgess W H; Ullrich A; Schlessinger J
SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.
The EMBO journal 1992;11(2):559-67.
1992: Dionne C A; Modi W S; Crumley G; O'Brien S J; Schlessinger J; Jaye M
BEK, a receptor for multiple members of the fibroblast growth factor (FGF) family, maps to human chromosome 10q25.3----q26.
Cytogenetics and cell genetics 1992;60(1):34-6.
1992: Schlessinger J; Mohammadi M; Margolis B; Ullrich A
Role of SH2-containing proteins in cellular signaling by receptor tyrosine kinases.
Cold Spring Harbor symposia on quantitative biology 1992;57():67-74.
1991: Crumley G; Bellot F; Kaplow J M; Schlessinger J; Jaye M; Dionne C A
High-affinity binding and activation of a truncated FGF receptor by both aFGF and bFGF.
Oncogene 1991;6(12):2255-62.
1991: Hurwitz D R; Emanuel S L; Nathan M H; Sarver N; Ullrich A; Felder S; Lax I; Schlessinger J
EGF induces increased ligand binding affinity and dimerization of soluble epidermal growth factor (EGF) receptor extracellular domain.
The Journal of biological chemistry 1991;266(32):22035-43.
1991: Mohammadi M; Honegger A M; Rotin D; Fischer R; Bellot F; Li W; Dionne C A; Jaye M; Rubinstein M; Schlessinger J
A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.
Molecular and cellular biology 1991;11(10):5068-78.
1991: Bellot F; Crumley G; Kaplow J M; Schlessinger J; Jaye M; Dionne C A
Ligand-induced transphosphorylation between different FGF receptors.
The EMBO journal 1991;10(10):2849-54.
1991: Li W; Hack N; Margolis B; Ullrich A; Skorecki K; Schlessinger J
Carboxy-terminal truncations of epidermal growth factor (EGF) receptor affect diverse EGF-induced cellular responses.
Cell regulation 1991;2(8):641-9.
1991: Lax I; Mitra A K; Ravera C; Hurwitz D R; Rubinstein M; Ullrich A; Stroud R M; Schlessinger J
Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain.
The Journal of biological chemistry 1991;266(21):13828-33.
1991: Li W; Schlessinger J
Platelet-derived growth factor (PDGF)-induced disulfide-linked dimerization of PDGF receptor in living cells.
Molecular and cellular biology 1991;11(7):3756-61.
1991: Adnane J; Gaudray P; Dionne C A; Crumley G; Jaye M; Schlessinger J; Jeanteur P; Birnbaum D; Theillet C
BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers.
Oncogene 1991;6(4):659-63.
1991: Skolnik E Y; Margolis B; Mohammadi M; Lowenstein E; Fischer R; Drepps A; Ullrich A; Schlessinger J
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases.
Cell 1991;65(1):83-90.
1991: Kashles O; Yarden Y; Fischer R; Ullrich A; Schlessinger J
A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.
Molecular and cellular biology 1991;11(3):1454-63.
1991: Kris R M; South V; Saltzman A; Felder S; Ricca G A; Jaye M; Huebner K; Kagan J; Croce C M; Schlessinger J
Cloning and expression of the human substance K receptor and analysis of its role in mitogenesis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991;2(1):15-22.
1991: Oval J; Hershberg R; Gansbacher B; Gilboa E; Schlessinger J; Taetle R
Expression of functional epidermal growth factor receptors in a human hematopoietic cell line.
Cancer research 1991;51(1):150-6.
1991: Birnbaum D; deLapeyriere O; Adnane J; Dionne C; Crumley G; Jaye M; Schlessinger J; Xerri L; Escot C; Gaudray P
Role of FGFs and FGF receptors in human carcinogenesis.
Annals of the New York Academy of Sciences 1991;638():409-11.
1991: Cyr C; South V; Saltzman A; Felder S; Ricca G A; Jaye M; Huebner K; Kagan J; Croce C M; Schlessinger J
Cloning, expression of the human substance K receptor, and analysis of its role in mitogenesis.
Annals of the New York Academy of Sciences 1991;632():426-7.
1990: Margolis B; Li N; Koch A; Mohammadi M; Hurwitz D R; Zilberstein A; Ullrich A; Pawson T; Schlessinger J
The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.
The EMBO journal 1990;9(13):4375-80.
1990: Kaplan R; Morse B; Huebner K; Croce C; Howk R; Ravera M; Ricca G; Jaye M; Schlessinger J
Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(18):7000-4.
1990: Burgess W H; Dionne C A; Kaplow J; Mudd R; Friesel R; Zilberstein A; Schlessinger J; Jaye M
Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
Molecular and cellular biology 1990;10(9):4770-7.
1990: Dionne C A; Crumley G; Bellot F; Kaplow J M; Searfoss G; Ruta M; Burgess W H; Jaye M; Schlessinger J
Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.
The EMBO journal 1990;9(9):2685-92.
1990: Sap J; D'Eustachio P; Givol D; Schlessinger J
Cloning and expression of a widely expressed receptor tyrosine phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(16):6112-6.
1990: Honegger A M; Schmidt A; Ullrich A; Schlessinger J
Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells.
Molecular and cellular biology 1990;10(8):4035-44.
1990: Cirillo D; Naldini L; Moody T W; Comoglio P; Schlessinger J; Kris R
Characterization of the detergent solubilized receptor for gastrin-releasing peptide.
Peptides 1990;11(4):737-45.
1990: Felder S; Miller K; Moehren G; Ullrich A; Schlessinger J; Hopkins C R
Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body.
Cell 1990;61(4):623-34.
1990: Honegger A M; Schmidt A; Ullrich A; Schlessinger J
Separate endocytic pathways of kinase-defective and -active EGF receptor mutants expressed in same cells.
The Journal of cell biology 1990;110(5):1541-8.
1990: Margolis B; Zilberstein A; Franks C; Felder S; Kremer S; Ullrich A; Rhee S G; Skorecki K; Schlessinger J
Effect of phospholipase C-gamma overexpression on PDGF-induced second messengers and mitogenesis.
Science (New York, N.Y.) 1990;248(4955):607-10.
1990: Naldini L; Cirillo D; Moody T W; Comoglio P M; Schlessinger J; Kris R
Solubilization of the receptor for the neuropeptide gastrin-releasing peptide (bombesin) with functional ligand binding properties.
Biochemistry 1990;29(21):5153-60.
1990: Hsu C Y; Mohammadi M; Nathan M; Honegger A; Ullrich A; Schlessinger J; Hurwitz D R
Generation of recombinant cytoplasmic domain of epidermal growth factor receptor with intrinsic protein tyrosine kinase activity.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(4):191-200.
1990: Bellot F; Moolenaar W; Kris R; Mirakhur B; Verlaan I; Ullrich A; Schlessinger J; Felder S
High-affinity epidermal growth factor binding is specifically reduced by a monoclonal antibody, and appears necessary for early responses.
The Journal of cell biology 1990;110(2):491-502.
1990: Margolis B; Bellot F; Honegger A M; Ullrich A; Schlessinger J; Zilberstein A
Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor.
Molecular and cellular biology 1990;10(2):435-41.
1990: Lax I; Bellot F; Honegger A M; Schmidt A; Ullrich A; Givol D; Schlessinger J
Domain deletion in the extracellular portion of the EGF-receptor reduces ligand binding and impairs cell surface expression.
Cell regulation 1990;1(2):173-88.
1990: Hazan R; Margolis B; Dombalagian M; Ullrich A; Zilberstein A; Schlessinger J
Identification of autophosphorylation sites of HER2/neu.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(1):3-7.
1989: Ruta M; Burgess W; Givol D; Epstein J; Neiger N; Kaplow J; Crumley G; Dionne C; Jaye M; Schlessinger J
Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG).
Proceedings of the National Academy of Sciences of the United States of America 1989;86(22):8722-6.
1989: Lyall R M; Zilberstein A; Gazit A; Gilon C; Levitzki A; Schlessinger J
Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation.
The Journal of biological chemistry 1989;264(24):14503-9.
1989: Margolis B L; Lax I; Kris R; Dombalagian M; Honegger A M; Howk R; Givol D; Ullrich A; Schlessinger J
All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor.
The Journal of biological chemistry 1989;264(18):10667-71.
1989: Margolis B; Rhee S G; Felder S; Mervic M; Lyall R; Levitzki A; Ullrich A; Zilberstein A; Schlessinger J
EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling.
Cell 1989;57(7):1101-7.
1989: Honegger A M; Kris R M; Ullrich A; Schlessinger J
Evidence that autophosphorylation of solubilized receptors for epidermal growth factor is mediated by intermolecular cross-phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):925-9.
1989: Lax I; Bellot F; Howk R; Ullrich A; Givol D; Schlessinger J
Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules.
The EMBO journal 1989;8(2):421-7.
1988: Kashles O; Szapary D; Bellot F; Ullrich A; Schlessinger J; Schmidt A
Ligand-induced stimulation of epidermal growth factor receptor mutants with altered transmembrane regions.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9567-71.
1988: Honegger A; Dull T J; Bellot F; Van Obberghen E; Szapary D; Schmidt A; Ullrich A; Schlessinger J
Biological activities of EGF-receptor mutants with individually altered autophosphorylation sites.
The EMBO journal 1988;7(10):3045-52.
1988: Honegger A; Dull T J; Szapary D; Komoriya A; Kris R; Ullrich A; Schlessinger J
Kinetic parameters of the protein tyrosine kinase activity of EGF-receptor mutants with individually altered autophosphorylation sites.
The EMBO journal 1988;7(10):3053-60.
1988: Schlessinger J
The epidermal growth factor receptor as a multifunctional allosteric protein.
Biochemistry 1988;27(9):3119-23.
1988: Lax I; Johnson A; Howk R; Sap J; Bellot F; Winkler M; Ullrich A; Vennstrom B; Schlessinger J; Givol D
Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha.
Molecular and cellular biology 1988;8(5):1970-8.
1988: Lax I; Burgess W H; Bellot F; Ullrich A; Schlessinger J; Givol D
Localization of a major receptor-binding domain for epidermal growth factor by affinity labeling.
Molecular and cellular biology 1988;8(4):1831-4.
1988: Jaye M; Lyall R M; Mudd R; Schlessinger J; Sarver N
Expression of acidic fibroblast growth factor cDNA confers growth advantage and tumorigenesis to Swiss 3T3 cells.
The EMBO journal 1988;7(4):963-9.
1988: Schlessinger J; Ullrich A; Honegger A M; Moolenaar W H
Signal transduction by epidermal growth factor receptor.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():515-9.
1987: Honegger A M; Szapary D; Schmidt A; Lyall R; Van Obberghen E; Dull T J; Ullrich A; Schlessinger J
A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis.
Molecular and cellular biology 1987;7(12):4568-71.
1987: Honegger A M; Dull T J; Felder S; Van Obberghen E; Bellot F; Szapary D; Schmidt A; Ullrich A; Schlessinger J
Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing.
Cell 1987;51(2):199-209.
1987: Libermann T A; Friesel R; Jaye M; Lyall R M; Westermark B; Drohan W; Schmidt A; Maciag T; Schlessinger J
An angiogenic growth factor is expressed in human glioma cells.
The EMBO journal 1987;6(6):1627-32.

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