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Joseph Schlessinger

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Matthew J Davis; Byung Hak Ha; Ruth Halaban; Edna C Holman; Joseph Schlessinger; Titus Boggon
RAC1P29S is a spontaneously activating cancer-associated GTPase.
Sarah B Goldberg; Julie L Boyer; Joseph Schlessinger; Roy S Herbst
A step towards treating KRAS-mutant NSCLC.
Byung Hak Ha; Ruth Halaban; Michael Krauthammer; Hua Jane Lou; Joseph Schlessinger; Benjamin E Turk; Rong Zhang; Catherine Chen; Matthew J Davis; Jia Gao; Titus Boggon
Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.

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2013: Matthew J Davis; Byung Hak Ha; Ruth Halaban; Edna C Holman; Joseph Schlessinger; Titus Boggon
RAC1P29S is a spontaneously activating cancer-associated GTPase.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(3):912-7.
2013: Sarah B Goldberg; Julie L Boyer; Joseph Schlessinger; Roy S Herbst
A step towards treating KRAS-mutant NSCLC.
The lancet oncology 2013;14(1):3-5.
2012: Byung Hak Ha; Ruth Halaban; Michael Krauthammer; Hua Jane Lou; Joseph Schlessinger; Benjamin E Turk; Rong Zhang; Catherine Chen; Matthew J Davis; Jia Gao; Titus Boggon
Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(40):16107-12.
2012: Matthew J Davis; Joseph Schlessinger
The genesis of Zelboraf: targeting mutant B-Raf in melanoma.
The Journal of cell biology 2012;199(1):15-9.
2012: Michael Krauthammer; Richard P Lifton; Roger S Lo; Shuangge Ma; Shrikant M Mane; Miguel A Materin; James P McCusker; Deepak Narayan; Joseph Schlessinger; David F Stern; Mario Sznol; Stephan Ariyan; Antonella Bacchiocchi; Titus J Boggon; Marcus W Bosenberg; Douglas E Brash; Ana Capatana; Elaine Cheng; Murim Choi; Matthew J Davis; Ken Dutton-Regester; Perry Evans; Gerald Goh; Byung Hak Ha; Nicholas K Hayward; Edna C Holman; Kenneth K Kidd; Harriet M Kluger; Yong Kong; Ruth Halaban
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nature genetics 2012;44(9):1006-14.
2011: Hongying Shen; Shawn M Ferguson; Noah Dephoure; Ryan Park; Yan Yang; Laura A Volpicelli-Daley; Steven Gygi; Joseph Schlessinger; Pietro De Camilli
Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin.
Molecular biology of the cell 2011;22(4):493-502.
2011: Lynn A Kamen; Joseph Schlessinger; Clifford A Lowell
Pyk2 is required for neutrophil degranulation and host defense responses to bacterial infection.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(3):1656-65.
2010: Sören Beinke; Hyewon Phee; Jonathan M Clingan; Joseph Schlessinger; Mehrdad Matloubian; Arthur Weiss
Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(37):16234-9.
2010: Takuya Sato; Takuya Shimazaki; Hayato Naka; Shin-Ichi Fukami; Yasushi Satoh; Hideyuki Okano; Irit Lax; Joseph Schlessinger; Noriko Gotoh
FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells.
Stem cells (Dayton, Ohio) 2010;28(9):1661-73.
2010: Jae Hyun Bae; Joseph Schlessinger
Asymmetric tyrosine kinase arrangements in activation or autophosphorylation of receptor tyrosine kinases.
Molecules and cells 2010;29(5):443-8.
2010: Krishna P Ravindranathan; Valsan Mandiyan; Anil R Ekkati; Jae H Bae; Joseph Schlessinger; William L Jorgensen
Discovery of novel fibroblast growth factor receptor 1 kinase inhibitors by structure-based virtual screening.
Journal of medicinal chemistry 2010;53(4):1662-72.
2010: Jae Hyun Bae; Titus Boggon; Francisco Tomé; Valsan Mandiyan; Irit Lax; Joseph Schlessinger
Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(7):2866-71.
2010: Yan Yang; Peng Xie; Yarden Opatowsky; Joseph Schlessinger
Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(5):1906-11.
2010: Michiko Murohashi; Takahisa Nakamura; Satoshi Tanaka; T Ichise; Nobuaki Yoshida; Tadashi Yamamoto; Masabumi Shibuya; Joseph Schlessinger; Noriko Gotoh
An FGF4-FRS2alpha-Cdx2 axis in trophoblast stem cells induces Bmp4 to regulate proper growth of early mouse embryos.
Stem cells (Dayton, Ohio) 2010;28(1):113-21.
2009: David Margulies; Yarden Opatowsky; Stephen Fletcher; Ishu Saraogi; Lun K Tsou; Sourav Saha; Irit Lax; Joseph Schlessinger; Andrew D Hamilton
Surface binding inhibitors of the SCF-KIT protein-protein interaction.
Chembiochem : a European journal of chemical biology 2009;10(12):1955-8.
2009: Jae Hyun Bae; Erin Lew; satoru yuzawa; Francisco Tomé; Irit Lax; Joseph Schlessinger
The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.
Cell 2009;138(3):514-24.
2009: James Lulo; Satoru Yuzawa; Joseph Schlessinger
Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2.
Biochemical and biophysical research communications 2009;383(3):347-52.
2009: Erin Lew; Cristina M Furdui; Karen S Anderson; Joseph Schlessinger
The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations.
Science signaling 2009;2(58):ra6.
2008: Yan Yang; satoru yuzawa; Joseph Schlessinger
Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(22):7681-6.
2008: satoru yuzawa; Joseph Schlessinger
[Structural biology of receptor tyrosine kinase kit].
Seikagaku. The Journal of Japanese Biochemical Society 2008;80(2):94-104.
2008: Lu Wang; Ioannis Tassiulas; Kyung-Hyun Park-Min; Alicia C Reid; Hava Gil-Henn; Joseph Schlessinger; Roland Baron; J. Jue Zhang; Lionel B Ivashkiv
'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages.
Nature immunology 2008;9(2):186-93.
2007: Erin Lew; Jae Hyun Bae; Edyta Rohmann; Bernd Wollnik; Joseph Schlessinger
Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):19802-7.
2007: Imad Shams; Edyta Rohmann; Veraragavan Eswarakumar; Erin Lew; satoru yuzawa; Bernd Wollnik; Joseph Schlessinger; Irit Lax
Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway.
Molecular and cellular biology 2007;27(19):6903-12.
2007: Hava Gil-Henn; Olivier Destaing; Natalie Sims; Kazuhiro Aoki; Neil Alles; Lynn Neff; Archana Sanjay; Angela Bruzzaniti; Pietro De Camilli; Roland Baron; Joseph Schlessinger
Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice.
The Journal of cell biology 2007;178(6):1053-64.
2007: satoru yuzawa; Yarden Opatowsky; Zhongtao Zhang; Valsan Mandiyan; Irit Lax; Joseph Schlessinger
Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor.
Cell 2007;130(2):323-34.
2007: Veraragavan Eswarakumar; Joseph Schlessinger
Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3937-42.
2006: Veraragavan Eswarakumar; F Ozcan; Erin Lew; J H Bae; F Tomé; Carmen J Booth; D J Adams; Irit Lax; Joseph Schlessinger
Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(49):18603-8.
2006: Joseph Schlessinger; Mark A Lemmon
Nuclear signaling by receptor tyrosine kinases: the first robin of spring.
Cell 2006;127(1):45-8.
2006: Smaragda Lamprianou; Nathalie Vacaresse; Yoshihisa Suzuki; Hamid Meziane; Joseph Buxbaum; Joseph Schlessinger; Sheila Harroch
Receptor protein tyrosine phosphatase gamma is a marker for pyramidal cells and sensory neurons in the nervous system and is not necessary for normal development.
Molecular and cellular biology 2006;26(13):5106-19.
2006: Maria L Galisteo; Yan Yang; Jesus Ureña; Joseph Schlessinger
Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(26):9796-801.
2006: Ferruh Ozcan; Peter Klein; Mark A Lemmon; Irit Lax; Joseph Schlessinger
On the nature of low- and high-affinity EGF receptors on living cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5735-40.
2006: Edyta Rohmann; Han G Brunner; Hulya Kayserili; Oya Uyguner; Gudrun Nürnberg; Erin Lew; Angus Dobbie; Veraragavan Eswarakumar; Abdullah Uzumcu; Melike Ulubil-Emeroglu; Jules G Leroy; Yun Li; Christian Becker; Kai Lehnerdt; Cor W R J Cremers; Memnune Yüksel-Apak; Peter Nürnberg; Christian Kubisch; Chriütian Kubisch; Joseph Schlessinger; Hans van Bokhoven; Bernd Wollnik
Mutations in different components of FGF signaling in LADD syndrome.
Nature genetics 2006;38(4):414-7.
2006: Cristina M Furdui; Erin Lew; Joseph Schlessinger; Karen S Anderson
Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction.
Molecular cell 2006;21(5):711-7.
2005: S Yamamoto; I Yoshino; T Shimazaki; M Murohashi; Robert Hevner; Irit Lax; Hideyuki Okano; Masabumi Shibuya; Joseph Schlessinger; Noriko Gotoh
Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):15983-8.
2005: Noriko Gotoh; Katia Manova-Todorova; S Tanaka; M Murohashi; YR Hadari; A Lee; Y Hamada; T Hiroe; M Ito; T Kurihara; H Nakazato; M Shibuya; Irit Lax; Elizabeth Lacy; Joseph Schlessinger
The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development.
Molecular and cellular biology 2005;25(10):4105-16.
2005: Veraragavan Eswarakumar; Irit Lax; Joseph Schlessinger
Cellular signaling by fibroblast growth factor receptors.
Cytokine & growth factor reviews 2005;16(2):139-49.
2004: Noriko Gotoh; M Ito; S Yamamoto; I Yoshino; N Song; Yun Wang; Irit Lax; Joseph Schlessinger; M Shibuya; Richard Lang
Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(49):17144-9.
2004: Joseph Schlessinger
Common and distinct elements in cellular signaling via EGF and FGF receptors.
Science (New York, N.Y.) 2004;306(5701):1506-7.
2004: Betty Lamothe; Masashi Yamada; Ute Schaeper; Walter Birchmeier; Irit Lax; Joseph Schlessinger
The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway.
Molecular and cellular biology 2004;24(13):5657-66.
2004: Noriko Gotoh; Shaked Laks; Misako Nakashima; Irit Lax; Joseph Schlessinger
FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts.
FEBS letters 2004;564(1-2):14-8.
2004: Peter Klein; Dawn Mattoon; Mark A Lemmon; Joseph Schlessinger
A structure-based model for ligand binding and dimerization of EGF receptors.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(4):929-34.
2004: Dawn Mattoon; Peter Klein; Mark A Lemmon; Irit Lax; Joseph Schlessinger
The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(4):923-8.
2004: Shaun K Olsen; Omar A Ibrahimi; Angela Raucci; Fuming Zhang; Anna V Eliseenkova; Avner Yayon; Claudio Basilico; Robert J Linhardt; Joseph Schlessinger; Moosa Mohammadi
Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(4):935-40.
2004: Dawn Mattoon; Betty Lamothe; Irit Lax; Joseph Schlessinger
The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway.
BMC biology 2004;2():24.
2003: M Okigaki; C Davis; M Falasca; Sheila Harroch; DP Felsenfeld; Michael P Sheetz; Joseph Schlessinger
Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10740-5.
2003: Joseph Schlessinger; Mark A Lemmon
SH2 and PTB domains in tyrosine kinase signaling.
Science's STKE : signal transduction knowledge environment 2003;2003(191):RE12.
2003: Joseph Schlessinger
Signal transduction. Autoinhibition control.
Science (New York, N.Y.) 2003;300(5620):750-2.
2002: Sheila Harroch; Glaucia C Furtado; Wolfgang Brueck; Jack Rosenbluth; Juan J Lafaille; Moses Chao; Joseph Buxbaum; Joseph Schlessinger
A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions.
Nature genetics 2002;32(3):411-4.
2002: Irit Lax; Andy Wong; Betty Lamothe; Arnold Lee; Adam Frost; Jessica J Hawes; Joseph Schlessinger
The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors.
Molecular cell 2002;10(4):709-19.
2002: Joseph Schlessinger
Ligand-induced, receptor-mediated dimerization and activation of EGF receptor.
Cell 2002;110(6):669-72.
2002: Joseph Schlessinger
All signaling is local?
Molecular cell 2002;10(2):218-9.
2002: Andy Wong; Betty Lamothe; Arnold Lee; Joseph Schlessinger; Irit Lax; Arnold Li
FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6684-9.
2002: Joseph Schlessinger
A solid base for assaying protein kinase activity.
Nature biotechnology 2002;20(3):232-3.
2001: YR Hadari; Noriko Gotoh; H Kouhara; Irit Lax; Joseph Schlessinger
Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8578-83.
2001: Rosa Marina Melillo; Massimo Santoro; Sim-Heng Ong; Marc Billaud; Alfredo Fusco; YR Hadari; Joseph Schlessinger; Irit Lax
Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade.
Molecular and cellular biology 2001;21(13):4177-87.
2001: M Nishida; K Nagata; Y Hachimori; M Horiuchi; Kenji Ogura; Valsan Mandiyan; Joseph Schlessinger; Fuyuhiko Inagaki
Novel recognition mode between Vav and Grb2 SH3 domains.
The EMBO journal 2001;20(12):2995-3007.
2001: J Andreev; M L Galisteo; Onno Kranenburg; Susan K Logan; E S Chiu; M Okigaki; L A Cary; Wouter H Moolenaar; Joseph Schlessinger
Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade.
The Journal of biological chemistry 2001;276(23):20130-5.
2001: Sim-Heng Ong; YR Hadari; Noriko Gotoh; Graeme R Guy; Joseph Schlessinger; Irit Lax
Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6074-9.
2001: satoru yuzawa; Masashi Yokochi; Hideki Hatanaka; Kenji Ogura; M Kataoka; Kin-ichiro Miura; Valsan Mandiyan; Joseph Schlessinger; Fuyuhiko Inagaki
Solution structure of Grb2 reveals extensive flexibility necessary for target recognition.
Journal of molecular biology 2001;306(3):527-37.
2000: Joseph Schlessinger
Cell signaling by receptor tyrosine kinases.
Cell 2000;103(2):211-25.
2000: Sheila Harroch; M Palmeri; Jack Rosenbluth; Andrew W Custer; M Okigaki; Peter Shrager; Mariann M Blum; Joseph Buxbaum; Joseph Schlessinger
No obvious abnormality in mice deficient in receptor protein tyrosine phosphatase beta.
Molecular and cellular biology 2000;20(20):7706-15.
2000: Joseph Schlessinger; Alexander N Plotnikov; Omar A Ibrahimi; Anna V Eliseenkova; Brian K Yeh; Avner Yayon; Robert J Linhardt; Moosa Mohammadi
Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.
Molecular cell 2000;6(3):743-50.
2000: Z Zhang; R Zhang; A Joachimiak; Joseph Schlessinger; Xiang-Peng Kong
Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):7732-7.
2000: Alexander N Plotnikov; Stevan Hubbard; Joseph Schlessinger; Moosa Mohammadi
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Cell 2000;101(4):413-24.
2000: Joseph Schlessinger
New roles for Src kinases in control of cell survival and angiogenesis.
Cell 2000;100(3):293-6.
2000: G A Rodrigues; Marco Falasca; Z Zhang; Sim-Heng Ong; Joseph Schlessinger
A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling.
Molecular and cellular biology 2000;20(4):1448-59.
2000: Sim-Heng Ong; Graeme R Guy; YR Hadari; Shaked Laks; Noriko Gotoh; Joseph Schlessinger; Irit Lax
FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors.
Molecular and cellular biology 2000;20(3):979-89.
1999: Valsan Mandiyan; J Andreev; Joseph Schlessinger; Stevan Hubbard
Crystal structure of the ARF-GAP domain and ankyrin repeats of PYK2-associated protein beta.
The EMBO journal 1999;18(24):6890-8.
1999: Alexander N Plotnikov; Joseph Schlessinger; Stevan Hubbard; Moosa Mohammadi
Structural basis for FGF receptor dimerization and activation.
Cell 1999;98(5):641-50.
1999: Kenji Ogura; S Tsuchiya; H Terasawa; satoru yuzawa; Hideki Hatanaka; Valsan Mandiyan; Joseph Schlessinger; Fuyuhiko Inagaki
Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide.
Journal of molecular biology 1999;289(3):439-45.
1999: S Tsuchiya; Kenji Ogura; Hideki Hatanaka; K Nagata; H Terasawa; Valsan Mandiyan; Joseph Schlessinger; S Aimoto; H Ohta; Fuyuhiko Inagaki
Solution structure of the SH2 domain of Grb2/Ash complexed with EGF receptor-derived phosphotyrosine-containing peptide.
Journal of biochemistry 1999;125(6):1151-9.
1999: Akinori Takaoka; Naomi Tanaka; Y Mitani; Tsuyoshi Miyazaki; H Fujii; Masamitsu Sato; P Kovarik; T Decker; Joseph Schlessinger; Tadatsugu Taniguchi
Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling.
The EMBO journal 1999;18(9):2480-8.
1999: J Andreev; JP Simon; David D Sabatini; J Kam; Greg Plowman; P A Randazzo; Joseph Schlessinger
Identification of a new Pyk2 target protein with Arf-GAP activity.
Molecular and cellular biology 1999;19(3):2338-50.
1999: S Lev; J Hernandez; R Martinez; A Chen; Greg Plowman; Joseph Schlessinger
Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein.
Molecular and cellular biology 1999;19(3):2278-88.
1999: Kenji Ogura; K Nagata; Hideki Hatanaka; H Habuchi; K Kimata; S Tate; M W Ravera; M Jaye; Joseph Schlessinger; Fuyuhiko Inagaki
Solution structure of human acidic fibroblast growth factor and interaction with heparin-derived hexasaccharide.
Journal of biomolecular NMR 1999;13(1):11-24.
1998: H Moreno; M Nadal; Elena Leznik; Mutsuyuki Sugimori; Irit Lax; Joseph Schlessinger; Rodolfo R Llinás
Nerve growth factor acutely reduces chemical transmission by means of postsynaptic TrkA-like receptors in squid giant synapse.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14997-5002.
1998: Moosa Mohammadi; Stuart Froum; James M Hamby; Mel C Schroeder; RL Panek; GH Lu; Anna V Eliseenkova; David Green; Joseph Schlessinger; Stevan Hubbard
Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.
The EMBO journal 1998;17(20):5896-904.
1998: YR Hadari; H Kouhara; Irit Lax; Joseph Schlessinger
Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation.
Molecular and cellular biology 1998;18(7):3966-73.
1998: Stevan Hubbard; Moosa Mohammadi; Joseph Schlessinger
Autoregulatory mechanisms in protein-tyrosine kinases.
The Journal of biological chemistry 1998;273(20):11987-90.
1998: Tsuyoshi Miyazaki; Akinori Takaoka; L Nogueira; I Dikic; H Fujii; S Tsujino; Y Mitani; M Maeda; Joseph Schlessinger; Tadatsugu Taniguchi
Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway.
Genes & development 1998;12(6):770-5.
1998: Marco Falasca; Susan K Logan; V P Lehto; G Baccante; Mark A Lemmon; Joseph Schlessinger
Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.
The EMBO journal 1998;17(2):414-22.
1997: Joseph Schlessinger
Direct binding and activation of receptor tyrosine kinases by collagen.
Cell 1997;91(7):869-72.
1997: Z Zhang; C H Lee; Valsan Mandiyan; Jean-Paul Borg; Benjamin L Margolis; Joseph Schlessinger; John Kuriyan
Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.
The EMBO journal 1997;16(20):6141-50.
1997: Kenji Ogura; S Tsuchiya; H Terasawa; satoru yuzawa; Hideki Hatanaka; Valsan Mandiyan; Joseph Schlessinger; Fuyuhiko Inagaki
Conformation of an Shc-derived phosphotyrosine-containing peptide complexed with the Grb2 SH2 domain.
Journal of biomolecular NMR 1997;10(3):273-8.
1997: Susan K Logan; Marco Falasca; Patrick J Hu; Joseph Schlessinger
Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway.
Molecular and cellular biology 1997;17(10):5784-90.
1997: H Kouhara; YR Hadari; T Spivak-Kroizman; J Schilling; D Bar-Sagi; Irit Lax; Joseph Schlessinger
A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway.
Cell 1997;89(5):693-702.
1997: G A Rodrigues; M Park; Joseph Schlessinger
Activation of the JNK pathway is essential for transformation by the Met oncogene.
The EMBO journal 1997;16(10):2634-45.
1997: Moosa Mohammadi; Gerald McMahon; Li Sun; Cho Tang; P Hirth; Brian K Yeh; Stevan Hubbard; Joseph Schlessinger
Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
Science (New York, N.Y.) 1997;276(5314):955-60.
1997: Joseph Schlessinger
Phospholipase Cgamma activation and phosphoinositide hydrolysis are essential for embryonal development.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):2798-9.
1997: Mark A Lemmon; D Pinchasi; M Zhou; Irit Lax; Joseph Schlessinger
Kit receptor dimerization is driven by bivalent binding of stem cell factor.
The Journal of biological chemistry 1997;272(10):6311-7.
1997: Rodolfo R Llinás; H Moreno; Mutsuyuki Sugimori; Moosa Mohammadi; Joseph Schlessinger
Differential pre- and postsynaptic modulation of chemical transmission in the squid giant synapse by tyrosine phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1990-4.
1997: Elior Peles; M Nativ; Marc J Lustig; Martin Grumet; J Schilling; R Martinez; Greg Plowman; Joseph Schlessinger
Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions.
The EMBO journal 1997;16(5):978-88.
1997: Takeshi Sakurai; Marc J Lustig; M Nativ; J J Hemperly; Joseph Schlessinger; Elior Peles; Martin Grumet
Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta.
The Journal of cell biology 1997;136(4):907-18.
1997: Mark A Lemmon; Zimei Bu; J E Ladbury; M Zhou; D Pinchasi; Irit Lax; D M Engelman; Joseph Schlessinger
Two EGF molecules contribute additively to stabilization of the EGFR dimer.
The EMBO journal 1997;16(2):281-94.
1996: M Sahni; X M Zhou; L Bakiri; Joseph Schlessinger; Roland Baron; J B Levy
Identification of a novel 135-kDa Grb2-binding protein in osteoclasts.
The Journal of biological chemistry 1996;271(51):33141-7.
1996: M Roghani; Moosa Mohammadi; Joseph Schlessinger; D Moscatelli
Induction of urokinase-type plasminogen activator by fibroblast growth factor (FGF)-2 is dependent on expression of FGF receptors and does not require activation of phospholipase Cgamma1.
The Journal of biological chemistry 1996;271(49):31154-9.
1996: Ivan Dikic; G Tokiwa; S Lev; S A Courtneidge; Joseph Schlessinger
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation.
Nature 1996;383(6600):547-50.
1996: M L Galisteo; Jonathan Chernoff; YC Su; Edward Y Skolnik; Joseph Schlessinger
The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1.
The Journal of biological chemistry 1996;271(35):20997-1000.
1996: Moosa Mohammadi; Joseph Schlessinger; Stevan Hubbard
Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism.
Cell 1996;86(4):577-87.
1996: G Tokiwa; Ivan Dikic; S Lev; Joseph Schlessinger
Activation of Pyk2 by stress signals and coupling with JNK signaling pathway.
Science (New York, N.Y.) 1996;273(5276):792-4.
1996: Mark A Lemmon; Kathryn M Ferguson; Joseph Schlessinger
PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface.
Cell 1996;85(5):621-4.
1996: P D Canoll; Suzana Petanceska; Joseph Schlessinger; J M Musacchio
Three forms of RPTP-beta are differentially expressed during gliogenesis in the developing rat brain and during glial cell differentiation in culture.
Journal of neuroscience research 1996;44(3):199-215.
1996: Moosa Mohammadi; Ivan Dikic; A Sorokin; W H Burgess; Michael Jaye; Joseph Schlessinger
Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction.
Molecular and cellular biology 1996;16(3):977-89.
1996: Valsan Mandiyan; R O'Brien; M Zhou; Benjamin L Margolis; Mark A Lemmon; Julian M Sturtevant; Joseph Schlessinger
Thermodynamic studies of SHC phosphotyrosine interaction domain recognition of the NPXpY motif.
The Journal of biological chemistry 1996;271(9):4770-5.
1995: Kathryn M Ferguson; Mark A Lemmon; Joseph Schlessinger; Paul B Sigler
Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain.
Cell 1995;83(6):1037-46.
1995: Mark A Lemmon; Kathryn M Ferguson; R O'Brien; Paul B Sigler; Joseph Schlessinger
Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(23):10472-6.
1995: Joseph Schlessinger; Irit Lax; Mark A Lemmon
Regulation of growth factor activation by proteoglycans: what is the role of the low affinity receptors?
Cell 1995;83(3):357-60.
1995: F Mainiero; A Pepe; Kishore K Wary; laura spinardi; Moosa Mohammadi; Joseph Schlessinger; Filippo G Giancotti
Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes.
The EMBO journal 1995;14(18):4470-81.
1995: M L Galisteo; Ivan Dikic; A G Batzer; W Y Langdon; Joseph Schlessinger
Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation.
The Journal of biological chemistry 1995;270(35):20242-5.
1995: Kathryn M Ferguson; Mark A Lemmon; Paul B Sigler; Joseph Schlessinger
Scratching the surface with the PH domain.
Nature structural biology 1995;2(9):715-8.
1995: S Lev; H Moreno; R Martinez; P Canoll; Elior Peles; J M Musacchio; Greg Plowman; Bernardo Rudy; Joseph Schlessinger
Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions.
Nature 1995;376(6543):737-45.
1995: A G Batzer; PA Blaikie; K Nelson; Joseph Schlessinger; Benjamin L Margolis
The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor.
Molecular and cellular biology 1995;15(8):4403-9.
1995: Elior Peles; M Nativ; P L Campbell; Takeshi Sakurai; R Martinez; S Lev; D O Clary; J Schilling; Gilad Barnea; Greg Plowman; Martin Grumet; Joseph Schlessinger
The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin.
Cell 1995;82(2):251-60.
1995: R Fernandez; D Tabarini; N Azpiazu; Manfred Frasch; Joseph Schlessinger
The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential.
The EMBO journal 1995;14(14):3373-84.
1995: Ivan Dikic; A G Batzer; PA Blaikie; A Obermeier; A Ullrich; Joseph Schlessinger; Benjamin L Margolis
Shc binding to nerve growth factor receptor is mediated by the phosphotyrosine interaction domain.
The Journal of biological chemistry 1995;270(25):15125-9.
1995: H Wang; H Yan; P D Canoll; O Silvennoinen; Joseph Schlessinger; J M Musacchio
Expression of receptor protein tyrosine phosphatase-sigma (RPTP-sigma) in the nervous system of the developing and adult rat.
Journal of neuroscience research 1995;41(3):297-310.
1995: John E Ladbury; Mark A Lemmon; M Zhou; jeremy green; M C Botfield; Joseph Schlessinger
Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3199-203.
1995: Jiaoti Huang; Moosa Mohammadi; G A Rodrigues; Joseph Schlessinger
Reduced activation of RAF-1 and MAP kinase by a fibroblast growth factor receptor mutant deficient in stimulation of phosphatidylinositol hydrolysis.
The Journal of biological chemistry 1995;270(10):5065-72.
1995: Zhou Songyang; Kermit L Carraway; Michael J Eck; S C Harrison; Ricardo A Feldman; Moosa Mohammadi; Joseph Schlessinger; Stevan Hubbard; D P Smith; Charis Eng
Catalytic specificity of protein-tyrosine kinases is critical for selective signalling.
Nature 1995;373(6514):536-9.
1994: T Spivak-Kroizman; Mark A Lemmon; Ivan Dikic; John E Ladbury; D Pinchasi; Jiaoti Huang; Michael Jaye; G Crumley; Joseph Schlessinger; Irit Lax
Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation.
Cell 1994;79(6):1015-24.
1994: Mark A Lemmon; John E Ladbury; Valsan Mandiyan; M Zhou; Joseph Schlessinger
Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2.
The Journal of biological chemistry 1994;269(50):31653-8.
1994: N Li; Joseph Schlessinger; Benjamin L Margolis
Autophosphorylation mutants of the EGF-receptor signal through auxiliary mechanisms involving SH2 domain proteins.
Oncogene 1994;9(12):3457-65.
1994: H Terasawa; Daisuke Kohda; Hideki Hatanaka; S Tsuchiya; Kenji Ogura; K Nagata; S Ishii; Valsan Mandiyan; A Ullrich; Joseph Schlessinger
Structure of the N-terminal SH3 domain of GRB2 complexed with a peptide from the guanine nucleotide releasing factor Sos.
Nature structural biology 1994;1(12):891-7.
1994: Daisuke Kohda; H Terasawa; S Ichikawa; Kenji Ogura; Hideki Hatanaka; Valsan Mandiyan; A Ullrich; Joseph Schlessinger; Fuyuhiko Inagaki
Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2.
Structure (London, England : 1993) 1994;2(11):1029-40.
1994: M A Lemmon; Joseph Schlessinger
Regulation of signal transduction and signal diversity by receptor oligomerization.
Trends in biochemical sciences 1994;19(11):459-63.
1994: Kathryn M Ferguson; Mark A Lemmon; Joseph Schlessinger; Paul B Sigler
Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin.
Cell 1994;79(2):199-209.
1994: D M Desai; Jan Sap; O Silvennoinen; Joseph Schlessinger; Arthur Weiss
The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation.
The EMBO journal 1994;13(17):4002-10.
1994: Ivan Dikic; Joseph Schlessinger; Irit Lax
PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation.
Current biology : CB 1994;4(8):702-8.
1994: A G Batzer; D Rotin; J M Ureña; Edward Y Skolnik; Joseph Schlessinger
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.
Molecular and cellular biology 1994;14(8):5192-201.
1994: Peter S McPherson; Andrew J Czernik; T J Chilcote; Franco Onofri; Fabio Benfenati; Paul Greengard; Joseph Schlessinger; Pietro De Camilli
Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(14):6486-90.
1994: M Sieh; A Batzer; Joseph Schlessinger; Arthur Weiss
GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation.
Molecular and cellular biology 1994;14(7):4435-42.
1994: A Sorokin; Moosa Mohammadi; Jiaoti Huang; Joseph Schlessinger
Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766.
The Journal of biological chemistry 1994;269(25):17056-61.
1994: T Spivak-Kroizman; Moosa Mohammadi; Patrick J Hu; Michael Jaye; Joseph Schlessinger; Irit Lax
Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells.
The Journal of biological chemistry 1994;269(20):14419-23.
1994: Gilad Barnea; Martin Grumet; P Milev; O Silvennoinen; J B Levy; Jan Sap; Joseph Schlessinger
Receptor tyrosine phosphatase beta is expressed in the form of proteoglycan and binds to the extracellular matrix protein tenascin.
The Journal of biological chemistry 1994;269(20):14349-52.
1994: A Sorokin; Mark A Lemmon; A Ullrich; Joseph Schlessinger
Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond.
The Journal of biological chemistry 1994;269(13):9752-9.
1994: Patrick J Hu; Joseph Schlessinger
Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta.
Molecular and cellular biology 1994;14(4):2577-83.
1994: Joseph Schlessinger
SH2/SH3 signaling proteins.
Current opinion in genetics & development 1994;4(1):25-30.
1994: Gilad Barnea; Martin Grumet; Jan Sap; R U Margolis; Joseph Schlessinger
Close similarity between receptor-linked tyrosine phosphatase and rat brain proteoglycan.
Cell 1994;76(2):205.
1994: W Li; R Nishimura; A Kashishian; A G Batzer; W J Kim; J A Cooper; Joseph Schlessinger
A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase.
Molecular and cellular biology 1994;14(1):509-17.
1994: Jan Sap; Y P Jiang; David R Friedlander; Martin Grumet; Joseph Schlessinger
Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding.
Molecular and cellular biology 1994;14(1):1-9.
1994: Joseph Schlessinger; Dafna Bar-Sagi
Activation of Ras and other signaling pathways by receptor tyrosine kinases.
Cold Spring Harbor symposia on quantitative biology 1994;59():173-9.
1993: C H Lee; W Li; R Nishimura; M Zhou; A G Batzer; Martin G Myers Jr; M F White; Joseph Schlessinger; Edward Y Skolnik
Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11713-7.
1993: Patrick J Hu; A Mondino; Edward Y Skolnik; Joseph Schlessinger
Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85.
Molecular and cellular biology 1993;13(12):7677-88.
1993: H Yan; A Grossman; H Wang; Peter D'Eustachio; K Mossie; J M Musacchio; O Silvennoinen; Joseph Schlessinger
A novel receptor tyrosine phosphatase-sigma that is highly expressed in the nervous system.
The Journal of biological chemistry 1993;268(33):24880-6.
1993: Michael J Stern; L E Marengere; R J Daly; E J Lowenstein; M Kokel; A Batzer; P Olivier; Tony Pawson; Joseph Schlessinger
The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.
Molecular biology of the cell 1993;4(11):1175-88.
1993: R Nishimura; W Li; A Kashishian; A Mondino; M Zhou; J Cooper; Joseph Schlessinger
Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.
Molecular and cellular biology 1993;13(11):6889-96.
1993: P D Canoll; Gilad Barnea; J B Levy; Jan Sap; M Ehrlich; O Silvennoinen; Joseph Schlessinger; J M Musacchio
The expression of a novel receptor-type tyrosine phosphatase suggests a role in morphogenesis and plasticity of the nervous system.
Brain research. Developmental brain research 1993;75(2):293-8.
1993: O Silvennoinen; C Schindler; Joseph Schlessinger; David E Levy
Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation.
Science (New York, N.Y.) 1993;261(5129):1736-9.
1993: I Vietor; P Schwenger; W Li; Joseph Schlessinger; Jan Vilcek
Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein (MAP) kinase in human fibroblasts.
The Journal of biological chemistry 1993;268(25):18994-9.
1993: L L Chen; B Gansbacher; Eli Gilboa; R Taetle; J Oval; M S Hibbs; C K Huang; M L Clawson; SF Bilgrami; Joseph Schlessinger
Retroviral gene transfer of epidermal growth factor receptor into HL60 cells results in a partial block of retinoic acid-induced granulocytic differentiation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(9):769-76.
1993: Moosa Mohammadi; A Honegger; A Sorokin; A Ullrich; Joseph Schlessinger; D R Hurwitz
Aggregation-induced activation of the epidermal growth factor receptor protein tyrosine kinase.
Biochemistry 1993;32(34):8742-8.
1993: M Zhou; S Felder; M Rubinstein; D R Hurwitz; A Ullrich; I Lax; Joseph Schlessinger
Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activation.
Biochemistry 1993;32(32):8193-8.
1993: Joseph Schlessinger
How receptor tyrosine kinases activate Ras.
Trends in biochemical sciences 1993;18(8):273-5.
1993: Dafna Bar-Sagi; D Rotin; A Batzer; V Mandiyan; Joseph Schlessinger
SH3 domains direct cellular localization of signaling molecules.
Cell 1993;74(1):83-91.
1993: Edward Y Skolnik; A Batzer; N Li; C H Lee; E Lowenstein; Moosa Mohammadi; Benjamin L Margolis; Joseph Schlessinger
The function of GRB2 in linking the insulin receptor to Ras signaling pathways.
Science (New York, N.Y.) 1993;260(5116):1953-5.
1993: D M Desai; Jan Sap; Joseph Schlessinger; Arthur Weiss
Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase.
Cell 1993;73(3):541-54.
1993: N Li; A Batzer; R Daly; V Yajnik; Edward Y Skolnik; Pierre Chardin; Dafna Bar-Sagi; Benjamin L Margolis; Joseph Schlessinger
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.
Nature 1993;363(6424):85-8.
1993: nicholas gale; S Kaplan; E J Lowenstein; Joseph Schlessinger; Dafna Bar-Sagi
Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras.
Nature 1993;363(6424):88-92.
1993: Y P Jiang; H Wang; Peter D'Eustachio; J M Musacchio; Joseph Schlessinger; Jan Sap
Cloning and characterization of R-PTP-kappa, a new member of the receptor protein tyrosine phosphatase family with a proteolytically cleaved cellular adhesion molecule-like extracellular region.
Molecular and cellular biology 1993;13(5):2942-51.
1993: Daisuke Kohda; Hideki Hatanaka; M Odaka; Valsan Mandiyan; A Ullrich; Joseph Schlessinger; Fuyuhiko Inagaki
Solution structure of the SH3 domain of phospholipase C-gamma.
Cell 1993;72(6):953-60.
1993: Patrick J Hu; Benjamin L Margolis; Joseph Schlessinger
Vav: a potential link between tyrosine kinases and ras-like GTPases in hematopoietic cell signaling.
BioEssays : news and reviews in molecular, cellular and developmental biology 1993;15(3):179-83.
1993: S Felder; M Zhou; Patrick J Hu; J Ureña; A Ullrich; M Chaudhuri; M White; S E Shoelson; Joseph Schlessinger
SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange.
Molecular and cellular biology 1993;13(3):1449-55.
1993: Daisuke Kohda; M Odaka; I Lax; H Kawasaki; K Suzuki; A Ullrich; Joseph Schlessinger; Fuyuhiko Inagaki
A 40-kDa epidermal growth factor/transforming growth factor alpha-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor.
The Journal of biological chemistry 1993;268(3):1976-81.
1993: Clare Futter; S Felder; Joseph Schlessinger; A Ullrich; Colin Hopkins
Annexin I is phosphorylated in the multivesicular body during the processing of the epidermal growth factor receptor.
The Journal of cell biology 1993;120(1):77-83.
1993: Joseph Schlessinger
Cellular signaling by receptor tyrosine kinases.
Harvey lectures 1993;89():105-23.
1992: W Li; Patrick J Hu; Edward Y Skolnik; A Ullrich; Joseph Schlessinger
The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors.
Molecular and cellular biology 1992;12(12):5824-33.
1992: Benjamin L Margolis; O Silvennoinen; F Comoglio; Chanland Roonprapunt; Edward Y Skolnik; A Ullrich; Joseph Schlessinger
High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):8894-8.
1992: Moosa Mohammadi; Craig Dionne; W Li; N Li; T Spivak; A M Honegger; Michael Jaye; Joseph Schlessinger
Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis.
Nature 1992;358(6388):681-4.
1992: E J Lowenstein; R J Daly; A G Batzer; W Li; Benjamin L Margolis; R Lammers; A Ullrich; Edward Y Skolnik; Dafna Bar-Sagi; Joseph Schlessinger
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.
Cell 1992;70(3):431-42.
1992: W Li; G G Deanin; Benjamin L Margolis; Joseph Schlessinger; J M Oliver
Fc epsilon R1-mediated tyrosine phosphorylation of multiple proteins, including phospholipase C gamma 1 and the receptor beta gamma 2 complex, in RBL-2H3 rat basophilic leukemia cells.
Molecular and cellular biology 1992;12(7):3176-82.
1992: D Rotin; A M Honegger; Benjamin L Margolis; A Ullrich; Joseph Schlessinger
Presence of SH2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor.
The Journal of biological chemistry 1992;267(14):9678-83.
1992: T Spivak-Kroizman; D Rotin; D Pinchasi; A Ullrich; Joseph Schlessinger; Irit Lax
Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses.
The Journal of biological chemistry 1992;267(12):8056-63.
1992: Benjamin L Margolis; Patrick J Hu; S Katzav; W Li; J M Oliver; A Ullrich; A Weiss; Joseph Schlessinger
Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs.
Nature 1992;356(6364):71-4.
1992: Patrick J Hu; Benjamin L Margolis; Edward Y Skolnik; R Lammers; A Ullrich; Joseph Schlessinger
Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors.
Molecular and cellular biology 1992;12(3):981-90.
1992: D Rotin; Benjamin L Margolis; Moosa Mohammadi; R J Daly; G Daum; N Li; Edmond H Fischer; W H Burgess; A Ullrich; Joseph Schlessinger
SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.
The EMBO journal 1992;11(2):559-67.
1992: Craig Dionne; W S Modi; G Crumley; S J O'Brien; Joseph Schlessinger; Michael Jaye
BEK, a receptor for multiple members of the fibroblast growth factor (FGF) family, maps to human chromosome 10q25.3----q26.
Cytogenetics and cell genetics 1992;60(1):34-6.
1992: Joseph Schlessinger; Moosa Mohammadi; Benjamin L Margolis; A Ullrich
Role of SH2-containing proteins in cellular signaling by receptor tyrosine kinases.
Cold Spring Harbor symposia on quantitative biology 1992;57():67-74.
1991: G Crumley; F Bellot; J M Kaplow; Joseph Schlessinger; Michael Jaye; Craig Dionne
High-affinity binding and activation of a truncated FGF receptor by both aFGF and bFGF.
Oncogene 1991;6(12):2255-62.
1991: D R Hurwitz; S L Emanuel; M H Nathan; N Sarver; A Ullrich; S Felder; I Lax; Joseph Schlessinger
EGF induces increased ligand binding affinity and dimerization of soluble epidermal growth factor (EGF) receptor extracellular domain.
The Journal of biological chemistry 1991;266(32):22035-43.
1991: Moosa Mohammadi; A M Honegger; D Rotin; R Fischer; F Bellot; W Li; Craig Dionne; Michael Jaye; M Rubinstein; Joseph Schlessinger
A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.
Molecular and cellular biology 1991;11(10):5068-78.
1991: F Bellot; G Crumley; J M Kaplow; Joseph Schlessinger; Michael Jaye; Craig Dionne
Ligand-induced transphosphorylation between different FGF receptors.
The EMBO journal 1991;10(10):2849-54.
1991: W Li; N Hack; Benjamin L Margolis; A Ullrich; K Skorecki; Joseph Schlessinger
Carboxy-terminal truncations of epidermal growth factor (EGF) receptor affect diverse EGF-induced cellular responses.
Cell regulation 1991;2(8):641-9.
1991: Irit Lax; A K Mitra; C Ravera; D R Hurwitz; M Rubinstein; A Ullrich; Robert M Stroud; Joseph Schlessinger
Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain.
The Journal of biological chemistry 1991;266(21):13828-33.
1991: W Li; Joseph Schlessinger
Platelet-derived growth factor (PDGF)-induced disulfide-linked dimerization of PDGF receptor in living cells.
Molecular and cellular biology 1991;11(7):3756-61.
1991: Edward Y Skolnik; Benjamin L Margolis; Moosa Mohammadi; E Lowenstein; R Fischer; A Drepps; A Ullrich; Joseph Schlessinger
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases.
Cell 1991;65(1):83-90.
1991: J Adnane; Patrick Gaudray; Craig Dionne; G Crumley; Michael Jaye; Joseph Schlessinger; P Jeanteur; Daniel Birnbaum; Charles Theillet
BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers.
Oncogene 1991;6(4):659-63.
1991: O Kashles; Y Yarden; R Fischer; A Ullrich; Joseph Schlessinger
A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.
Molecular and cellular biology 1991;11(3):1454-63.
1991: R M Kris; V South; A Saltzman; S Felder; G A Ricca; Michael Jaye; Kay Huebner; J Kagan; C M Croce; Joseph Schlessinger
Cloning and expression of the human substance K receptor and analysis of its role in mitogenesis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991;2(1):15-22.
1991: J Oval; R Hershberg; B Gansbacher; Eli Gilboa; Joseph Schlessinger; R Taetle
Expression of functional epidermal growth factor receptors in a human hematopoietic cell line.
Cancer research 1991;51(1):150-6.
1991: Daniel Birnbaum; O deLapeyriere; J Adnane; Craig Dionne; G Crumley; Michael Jaye; Joseph Schlessinger; Luc Xerri; C Escot; Patrick Gaudray
Role of FGFs and FGF receptors in human carcinogenesis.
Annals of the New York Academy of Sciences 1991;638():409-11.
1991: C Cyr; V South; A Saltzman; S Felder; G A Ricca; Michael Jaye; Kay Huebner; J Kagan; C M Croce; Joseph Schlessinger
Cloning, expression of the human substance K receptor, and analysis of its role in mitogenesis.
Annals of the New York Academy of Sciences 1991;632():426-7.
1990: Benjamin L Margolis; N Li; A Koch; Moosa Mohammadi; D R Hurwitz; A Zilberstein; A Ullrich; T Pawson; Joseph Schlessinger
The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.
The EMBO journal 1990;9(13):4375-80.
1990: R Kaplan; B Morse; Kay Huebner; C Croce; R Howk; M Ravera; G Ricca; Michael Jaye; Joseph Schlessinger
Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(18):7000-4.
1990: Wilson H Burgess; Craig Dionne; J Kaplow; R Mudd; R Friesel; A Zilberstein; Joseph Schlessinger; Michael Jaye
Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
Molecular and cellular biology 1990;10(9):4770-7.
1990: Craig Dionne; G Crumley; F Bellot; J M Kaplow; G Searfoss; M Ruta; W H Burgess; Michael Jaye; Joseph Schlessinger
Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.
The EMBO journal 1990;9(9):2685-92.
1990: Jan Sap; Peter D'Eustachio; D Givol; Joseph Schlessinger
Cloning and expression of a widely expressed receptor tyrosine phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(16):6112-6.
1990: A M Honegger; A Schmidt; A Ullrich; Joseph Schlessinger
Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells.
Molecular and cellular biology 1990;10(8):4035-44.
1990: D Cirillo; L Naldini; Terry W Moody; paolo comoglio; Joseph Schlessinger; R Kris
Characterization of the detergent solubilized receptor for gastrin-releasing peptide.
Peptides 1990;11(4):737-45.
1990: L Naldini; D Cirillo; Terry W Moody; paolo comoglio; Joseph Schlessinger; R Kris
Solubilization of the receptor for the neuropeptide gastrin-releasing peptide (bombesin) with functional ligand binding properties.
Biochemistry 1990;29(21):5153-60.
1990: S Felder; K Miller; G Moehren; A Ullrich; Joseph Schlessinger; Colin Hopkins
Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body.
Cell 1990;61(4):623-34.
1990: Benjamin L Margolis; Asher Zilberstein; C Franks; S Felder; S Kremer; A Ullrich; S G Rhee; K Skorecki; Joseph Schlessinger
Effect of phospholipase C-gamma overexpression on PDGF-induced second messengers and mitogenesis.
Science (New York, N.Y.) 1990;248(4955):607-10.
1990: A M Honegger; A Schmidt; A Ullrich; Joseph Schlessinger
Separate endocytic pathways of kinase-defective and -active EGF receptor mutants expressed in same cells.
The Journal of cell biology 1990;110(5):1541-8.
1990: C Y Hsu; Moosa Mohammadi; M Nathan; A Honegger; A Ullrich; Joseph Schlessinger; D R Hurwitz
Generation of recombinant cytoplasmic domain of epidermal growth factor receptor with intrinsic protein tyrosine kinase activity.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(4):191-200.
1990: F Bellot; W Moolenaar; R Kris; B Mirakhur; I Verlaan; A Ullrich; Joseph Schlessinger; S Felder
High-affinity epidermal growth factor binding is specifically reduced by a monoclonal antibody, and appears necessary for early responses.
The Journal of cell biology 1990;110(2):491-502.
1990: Benjamin L Margolis; F Bellot; A M Honegger; A Ullrich; Joseph Schlessinger; A Zilberstein
Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor.
Molecular and cellular biology 1990;10(2):435-41.
1990: I Lax; F Bellot; A M Honegger; A Schmidt; A Ullrich; D Givol; Joseph Schlessinger
Domain deletion in the extracellular portion of the EGF-receptor reduces ligand binding and impairs cell surface expression.
Cell regulation 1990;1(2):173-88.
1990: Rachel B Hazan; Benjamin L Margolis; M Dombalagian; A Ullrich; Asher Zilberstein; Joseph Schlessinger
Identification of autophosphorylation sites of HER2/neu.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(1):3-7.
1989: M Ruta; W Burgess; D Givol; J Epstein; N Neiger; J Kaplow; G Crumley; Craig Dionne; Michael Jaye; Joseph Schlessinger
Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG).
Proceedings of the National Academy of Sciences of the United States of America 1989;86(22):8722-6.
1989: R M Lyall; Asher Zilberstein; A Gazit; C Gilon; A Levitzki; Joseph Schlessinger
Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation.
The Journal of biological chemistry 1989;264(24):14503-9.
1989: Benjamin L Margolis; S G Rhee; S Felder; M Mervic; R Lyall; A Levitzki; A Ullrich; Asher Zilberstein; Joseph Schlessinger
EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling.
Cell 1989;57(7):1101-7.
1989: Benjamin L Margolis; I Lax; R Kris; M Dombalagian; A M Honegger; R Howk; D Givol; A Ullrich; Joseph Schlessinger
All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor.
The Journal of biological chemistry 1989;264(18):10667-71.
1989: A M Honegger; R M Kris; A Ullrich; Joseph Schlessinger
Evidence that autophosphorylation of solubilized receptors for epidermal growth factor is mediated by intermolecular cross-phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):925-9.
1989: I Lax; F Bellot; R Howk; A Ullrich; D Givol; Joseph Schlessinger
Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules.
The EMBO journal 1989;8(2):421-7.
1988: O Kashles; D Szapary; F Bellot; A Ullrich; Joseph Schlessinger; A Schmidt
Ligand-induced stimulation of epidermal growth factor receptor mutants with altered transmembrane regions.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9567-71.
1988: A Honegger; T J Dull; F Bellot; E Van Obberghen; D Szapary; A Schmidt; A Ullrich; Joseph Schlessinger
Biological activities of EGF-receptor mutants with individually altered autophosphorylation sites.
The EMBO journal 1988;7(10):3045-52.
1988: A Honegger; T J Dull; D Szapary; A Komoriya; R Kris; A Ullrich; Joseph Schlessinger
Kinetic parameters of the protein tyrosine kinase activity of EGF-receptor mutants with individually altered autophosphorylation sites.
The EMBO journal 1988;7(10):3053-60.
1988: Joseph Schlessinger
The epidermal growth factor receptor as a multifunctional allosteric protein.
Biochemistry 1988;27(9):3119-23.
1988: I Lax; A Johnson; R Howk; J Sap; F Bellot; M Winkler; A Ullrich; B Vennstrom; Joseph Schlessinger; D Givol
Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha.
Molecular and cellular biology 1988;8(5):1970-8.
1988: I Lax; W H Burgess; F Bellot; A Ullrich; Joseph Schlessinger; D Givol
Localization of a major receptor-binding domain for epidermal growth factor by affinity labeling.
Molecular and cellular biology 1988;8(4):1831-4.
1988: Michael Jaye; R M Lyall; R Mudd; Joseph Schlessinger; N Sarver
Expression of acidic fibroblast growth factor cDNA confers growth advantage and tumorigenesis to Swiss 3T3 cells.
The EMBO journal 1988;7(4):963-9.
1988: Joseph Schlessinger; A Ullrich; A M Honegger; W H Moolenaar
Signal transduction by epidermal growth factor receptor.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():515-9.
1987: A M Honegger; D Szapary; A Schmidt; R Lyall; E Van Obberghen; T J Dull; A Ullrich; Joseph Schlessinger
A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis.
Molecular and cellular biology 1987;7(12):4568-71.
1987: A M Honegger; T J Dull; S Felder; E Van Obberghen; F Bellot; D Szapary; A Schmidt; A Ullrich; Joseph Schlessinger
Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing.
Cell 1987;51(2):199-209.
1987: Towia Libermann; R Friesel; Michael Jaye; R M Lyall; B Westermark; W Drohan; A Schmidt; Thomas Maciag; Joseph Schlessinger
An angiogenic growth factor is expressed in human glioma cells.
The EMBO journal 1987;6(6):1627-32.